#Need to import the correct sheet from the original Simmons file
outfile1 <- here("Simmons_fILDPts_PFTs_2022_03_28.xlsx")
Simm_pft <- read_excel(outfile1, na="")Simm_pft <- Simm_pft %>% mutate_at(vars(pft_date, tx_date, dob, death_date, last_updated, dx_date, UPMC_lastvisit, Simmons_lastvisit, consent_date, first_pft_date), as.Date, format="%m/%d/%Y")
str(Simm_pft)## tibble [8,639 × 43] (S3: tbl_df/tbl/data.frame)
## $ ID : num [1:8639] 1097 1097 1405 1405 1405 ...
## $ pft_date : Date[1:8639], format: "2002-09-26" "2002-01-18" ...
## $ fvc_pct : num [1:8639] 31.3 31.9 65.7 64.7 61.8 ...
## $ dlco_pct : num [1:8639] NA NA 39.3 47.1 41.7 ...
## $ tx_date : Date[1:8639], format: NA NA ...
## $ dob : Date[1:8639], format: "1937-08-15" "1937-08-15" ...
## $ ADI_state : num [1:8639] 7 7 7 7 7 7 7 7 7 7 ...
## $ ADI_nat : num [1:8639] 67 67 73 73 73 73 73 73 73 73 ...
## $ lat : num [1:8639] 41.1 41.1 40.4 40.4 40.4 ...
## $ lon : num [1:8639] -80 -80 -79.8 -79.8 -79.8 ...
## $ City : chr [1:8639] "HARRISVILLE" "HARRISVILLE" "MONROEVILLE" "MONROEVILLE" ...
## $ State : chr [1:8639] "PA" "PA" "PA" "PA" ...
## $ zip5 : chr [1:8639] "16038" "16038" "15146" "15146" ...
## $ death_date : Date[1:8639], format: "2008-12-09" "2008-12-09" ...
## $ last_updated : Date[1:8639], format: "2021-01-27" "2021-01-27" ...
## $ dx_date : Date[1:8639], format: "2002-01-24" "2002-01-24" ...
## $ UPMC_lastvisit : Date[1:8639], format: "2008-10-15" "2008-10-15" ...
## $ Simmons_lastvisit : Date[1:8639], format: NA NA ...
## $ pkyrs : num [1:8639] NA NA 26 26 26 26 26 26 26 26 ...
## $ consent_date : Date[1:8639], format: "2003-02-27" "2003-02-27" ...
## $ first_pft_date : Date[1:8639], format: "2002-01-18" "2002-01-18" ...
## $ first_fvc_pct : num [1:8639] 31.9 31.9 53.6 53.6 53.6 ...
## $ first_dlco_pct : num [1:8639] NA NA 38.1 38.1 38.1 ...
## $ first_pft_timefromdx: num [1:8639] -0.0164 -0.0164 0 0 0 ...
## $ status : num [1:8639] 1 1 2 2 2 2 2 2 2 2 ...
## $ age_dx : num [1:8639] 64.4 64.4 44.7 44.7 44.7 ...
## $ time_censoring : num [1:8639] 6.72 6.72 19.93 19.93 19.93 ...
## $ time_death : num [1:8639] 6.87 6.87 NA NA NA ...
## $ time_tx : num [1:8639] NA NA 18 18 18 ...
## $ time_deathORtx : num [1:8639] 6.87 6.87 18.05 18.05 18.05 ...
## $ time_DeathTxCensor : num [1:8639] 6.87 6.87 18.05 18.05 18.05 ...
## $ sex : chr [1:8639] "F" "F" "F" "F" ...
## $ race : chr [1:8639] "B" "B" "W" "W" ...
## $ ethnicity : chr [1:8639] "N" "N" "N" "N" ...
## $ died : chr [1:8639] "1" "1" "0" "0" ...
## $ txed : chr [1:8639] "0" "0" "1" "1" ...
## $ deadORtx : chr [1:8639] "1" "1" "1" "1" ...
## $ dx_type : chr [1:8639] "Primary" "Primary" "Primary" "Primary" ...
## $ dx : chr [1:8639] "SSC_ILD" "SSC_ILD" "SSC_ILD" "SSC_ILD" ...
## $ smokeHx : chr [1:8639] NA NA "Former" "Former" ...
## $ dich_Race : chr [1:8639] "Non-White" "Non-White" "White" "White" ...
## $ dich_smoking : chr [1:8639] NA NA "Ever" "Ever" ...
## $ dx_group : chr [1:8639] "CTD-ILD" "CTD-ILD" "CTD-ILD" "CTD-ILD" ...This will make it easier to identify any cells with issues and replace them if needed
Simm_pft <- Simm_pft %>% mutate(pft_id=1:8639)Simm_pft <- Simm_pft %>% dplyr::select(ID, pft_date, fvc_pct, dlco_pct)
str(Simm_pft)## tibble [8,639 × 4] (S3: tbl_df/tbl/data.frame)
## $ ID : num [1:8639] 1097 1097 1405 1405 1405 ...
## $ pft_date: Date[1:8639], format: "2002-09-26" "2002-01-18" ...
## $ fvc_pct : num [1:8639] 31.3 31.9 65.7 64.7 61.8 ...
## $ dlco_pct: num [1:8639] NA NA 39.3 47.1 41.7 ...Simm_pft$cohort <- "Simmons"#Need to import the correct sheet from the original PFF file
outfile1 <- here("PFF_FormatData_2021_10_06.xlsx")
PFF_FVC <- read_excel(outfile1, sheet="FVC", na="")
PFF_DLCO <- read_excel(outfile1, sheet="DLCO", na="")PFF_FVC <- PFF_FVC %>% dplyr::select(SSID, TestDays, pctFVC)
str(PFF_FVC)## tibble [9,118 × 3] (S3: tbl_df/tbl/data.frame)
## $ SSID : chr [1:9118] "02R0456" "02R0456" "02R0462" "02R0462" ...
## $ TestDays: num [1:9118] -98 -63 -84 -644 415 ...
## $ pctFVC : num [1:9118] 58.3 58.5 54.4 61.5 78.2 ...PFF_DLCO <- PFF_DLCO %>% dplyr::select(SSID, TestDays, pctDLCOuncorr)
str(PFF_DLCO)## tibble [7,643 × 3] (S3: tbl_df/tbl/data.frame)
## $ SSID : chr [1:7643] "02R0456" "02R0456" "02R0462" "02R0462" ...
## $ TestDays : num [1:7643] -63 -98 -84 -644 1106 ...
## $ pctDLCOuncorr: num [1:7643] 28.8 26.8 32.7 52.9 57.8 ...I created a new ID for PFF that is only numbers that is distinct from CARE and Simmons IDs and allows us to get rid of the SSID
outfile2 <- here("PFF_fILD_AllConstituentsMatched_2022_07_28.xlsx")
PM_PFF <- read_excel(outfile2, na="")PM_PFF$ID <- paste("11111", PM_PFF$ID, sep="")
PM_PFF <- PM_PFF %>% dplyr::select(ID, SSID, consent_date)
PM_PFF$consent_date <- as.Date(PM_PFF$consent_date)PFF_FVC <- right_join(PM_PFF, PFF_FVC, by="SSID")
PFF_DLCO <- right_join(PM_PFF, PFF_DLCO, by="SSID")PFF_FVC <- PFF_FVC %>% mutate(pft_date = as.Date(consent_date + lubridate::days(TestDays)))
PFF_FVC <- PFF_FVC %>% rename("fvc_pct"="pctFVC")
PFF_DLCO <- PFF_DLCO %>% mutate(pft_date = as.Date(consent_date + lubridate::days(TestDays)))
PFF_DLCO <- PFF_DLCO %>% rename("dlco_pct"="pctDLCOuncorr")PFF_FVC <- PFF_FVC %>% mutate(fvc_timefromcensor=(pft_date-consent_date)/365.25)
PFF_FVC$fvc_timefromcensor <- as.numeric(PFF_FVC$fvc_timefromcensor)
summary(PFF_FVC$fvc_timefromcensor)## Min. 1st Qu. Median Mean 3rd Qu. Max. NA's
## -15.3484 -0.2738 0.4791 0.6086 1.5332 4.9802 226PFF_FVC <- PFF_FVC %>% filter(fvc_timefromcensor>=-0.5)
summary(PFF_FVC$fvc_timefromcensor)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## -0.49829 0.09035 0.85695 1.06789 1.79603 4.98015PFF_DLCO <- PFF_DLCO %>% mutate(dlco_timefromcensor=(pft_date-consent_date)/365.25)
PFF_DLCO$dlco_timefromcensor <- as.numeric(PFF_DLCO$dlco_timefromcensor)
summary(PFF_DLCO$dlco_timefromcensor)## Min. 1st Qu. Median Mean 3rd Qu. Max. NA's
## -15.3484 -0.3121 0.4600 0.5871 1.5305 4.9802 188PFF_DLCO <- PFF_DLCO %>% filter(dlco_timefromcensor>=-0.5)
summary(PFF_DLCO$dlco_timefromcensor)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## -0.4983 0.0000 0.8679 1.0748 1.8207 4.9802str(PFF_FVC)## tibble [7,133 × 7] (S3: tbl_df/tbl/data.frame)
## $ ID : chr [1:7133] "111111" "111111" "111111" "111111" ...
## $ SSID : chr [1:7133] "24R0406" "24R0406" "24R0406" "24R0406" ...
## $ consent_date : Date[1:7133], format: "2016-09-23" "2016-09-23" ...
## $ TestDays : num [1:7133] 1266 1043 699 531 406 ...
## $ fvc_pct : num [1:7133] 69.6 75.4 59.9 64.8 57.2 ...
## $ pft_date : Date[1:7133], format: "2020-03-12" "2019-08-02" ...
## $ fvc_timefromcensor: num [1:7133] 3.47 2.86 1.91 1.45 1.11 ...PFF_FVC <- PFF_FVC %>% dplyr::select(ID, pft_date, fvc_pct)
str(PFF_DLCO)## tibble [5,892 × 7] (S3: tbl_df/tbl/data.frame)
## $ ID : chr [1:5892] "111111" "111111" "111111" "111111" ...
## $ SSID : chr [1:5892] "24R0406" "24R0406" "24R0406" "24R0406" ...
## $ consent_date : Date[1:5892], format: "2016-09-23" "2016-09-23" ...
## $ TestDays : num [1:5892] 1266 1043 0 406 111 ...
## $ dlco_pct : num [1:5892] 75.3 73.2 80.4 76.9 72.3 ...
## $ pft_date : Date[1:5892], format: "2020-03-12" "2019-08-02" ...
## $ dlco_timefromcensor: num [1:5892] 3.466 2.856 0 1.112 0.304 ...PFF_DLCO <- PFF_DLCO %>% dplyr::select(ID, pft_date, dlco_pct)PFF_pft <- full_join(PFF_FVC, PFF_DLCO, by=c("ID","pft_date"))
PFF_pft <- PFF_pft %>% filter(!is.na(ID))PFF_pft$cohort <- "PFF"#Need to import the correct sheet from the original Simmons file
outfile1 <- here("CAREPF_AllPts_PFTs_2021_06_01.xlsx")
CARE_pft <- read_excel(outfile1, na="")CARE_pft <- CARE_pft %>% mutate_at(vars(pft_date, tx_date, dx_date), as.Date, format="%m/%d/%Y")CARE_pft <- CARE_pft %>% dplyr::select(ID, pft_date, fvc_pct, dlco_pct)
str(CARE_pft)## tibble [29,002 × 4] (S3: tbl_df/tbl/data.frame)
## $ ID : num [1:29002] 10300303 10300303 10300304 10300304 10300305 ...
## $ pft_date: Date[1:29002], format: "2011-11-22" "2014-06-10" ...
## $ fvc_pct : num [1:29002] 101 102 113 109 59 60 66 79 62 77 ...
## $ dlco_pct: num [1:29002] 57 44 70 69 33 48 51 NA 65 NA ...CARE_pft$cohort <- "CARE-PF"str(Simm_pft)## tibble [8,639 × 5] (S3: tbl_df/tbl/data.frame)
## $ ID : num [1:8639] 1097 1097 1405 1405 1405 ...
## $ pft_date: Date[1:8639], format: "2002-09-26" "2002-01-18" ...
## $ fvc_pct : num [1:8639] 31.3 31.9 65.7 64.7 61.8 ...
## $ dlco_pct: num [1:8639] NA NA 39.3 47.1 41.7 ...
## $ cohort : chr [1:8639] "Simmons" "Simmons" "Simmons" "Simmons" ...str(PFF_pft)## tibble [7,265 × 5] (S3: tbl_df/tbl/data.frame)
## $ ID : chr [1:7265] "111111" "111111" "111111" "111111" ...
## $ pft_date: Date[1:7265], format: "2020-03-12" "2019-08-02" ...
## $ fvc_pct : num [1:7265] 69.6 75.4 59.9 64.8 57.2 ...
## $ dlco_pct: num [1:7265] 75.3 73.2 74.3 87 76.9 ...
## $ cohort : chr [1:7265] "PFF" "PFF" "PFF" "PFF" ...str(CARE_pft)## tibble [29,002 × 5] (S3: tbl_df/tbl/data.frame)
## $ ID : num [1:29002] 10300303 10300303 10300304 10300304 10300305 ...
## $ pft_date: Date[1:29002], format: "2011-11-22" "2014-06-10" ...
## $ fvc_pct : num [1:29002] 101 102 113 109 59 60 66 79 62 77 ...
## $ dlco_pct: num [1:29002] 57 44 70 69 33 48 51 NA 65 NA ...
## $ cohort : chr [1:29002] "CARE-PF" "CARE-PF" "CARE-PF" "CARE-PF" ...pft <- rbind(Simm_pft, PFF_pft, CARE_pft)Need to upload the file which only includes patients with fibrotic ILD
outfile2 <- here("CombinedCohorts_5yrPreCensoringANDPreDxData_2023_04_03.xlsx")
PM <- read_excel(outfile2, na="")PM <- PM %>% mutate_at(vars(DeathTxCensor_date, tx_date), as.Date, format="%m/%d/%Y")
str(PM)## tibble [6,683 × 38] (S3: tbl_df/tbl/data.frame)
## $ ID : chr [1:6683] "1097" "1405" "2796" "4742" ...
## $ cohort : chr [1:6683] "Simmons" "Simmons" "Simmons" "Simmons" ...
## $ site : chr [1:6683] "Simmons" "Simmons" "Simmons" "Simmons" ...
## $ dx_IPF : chr [1:6683] "not_IPF" "not_IPF" "not_IPF" "not_IPF" ...
## $ dx_yr : num [1:6683] 2002 1999 2003 1999 2015 ...
## $ sex : chr [1:6683] "F" "F" "M" "F" ...
## $ race : chr [1:6683] "B" "W" "W" "W" ...
## $ dich_Race : chr [1:6683] "Non-White" "White" "White" "White" ...
## $ smokeHx : chr [1:6683] "Unknown" "Former" "Never" "Unknown" ...
## $ age_dx : num [1:6683] 64.4 44.7 42.3 45.5 45.2 ...
## $ disadv : num [1:6683] 0.579 0.6725 0.5949 0.5152 0.0558 ...
## $ status : chr [1:6683] "1" "2" "0" "0" ...
## $ deadORtx : chr [1:6683] "1" "1" "0" "0" ...
## $ dx : chr [1:6683] "SSC_ILD" "SSC_ILD" "RA_ILD" "MCTD" ...
## $ dx_group : chr [1:6683] "CTD-ILD" "CTD-ILD" "CTD-ILD" "CTD-ILD" ...
## $ txed : chr [1:6683] "0" "1" "0" "0" ...
## $ tx_date : Date[1:6683], format: "NaN" "2019-04-18" ...
## $ DeathTxCensor_date: Date[1:6683], format: "2008-12-09" "2019-04-18" ...
## $ pft_date : POSIXct[1:6683], format: "2002-01-18" "1999-07-26" ...
## $ fvc_pct : num [1:6683] 31.9 53.6 82.5 47.6 62 ...
## $ dlco_pct : num [1:6683] NA 38.1 98.2 65.3 42 ...
## $ time_DeathTxCensor: num [1:6683] 6.87 18.05 20.43 19.16 1.45 ...
## $ PM_5yrPreDx : num [1:6683] 12.5 NA 14.7 NA 7.3 ...
## $ PM_5yrPreCensor : num [1:6683] 10.96 9.93 7.83 6.76 5.88 ...
## $ SO4_5yrPreDx : num [1:6683] 4.44 NA 5.86 NA 1.38 ...
## $ SO4_5yrPreCensor : num [1:6683] 3.873 2.239 1.626 1.426 0.783 ...
## $ NO3_5yrPreDx : num [1:6683] 1.388 NA 1.035 NA 0.527 ...
## $ NO3_5yrPreCensor : num [1:6683] 1.085 0.934 0.67 0.474 0.43 ...
## $ NH4_5yrPreDx : num [1:6683] 1.708 NA 2.017 NA 0.518 ...
## $ NH4_5yrPreCensor : num [1:6683] 1.49 0.786 0.483 0.374 0.139 ...
## $ BC_5yrPreDx : num [1:6683] 0.776 NA 0.861 NA 0.45 ...
## $ BC_5yrPreCensor : num [1:6683] 0.838 1.025 1.022 0.787 0.396 ...
## $ OM_5yrPreDx : num [1:6683] 2.89 NA 3.56 NA 2.05 ...
## $ OM_5yrPreCensor : num [1:6683] 3.3 3.79 3.67 3.03 1.96 ...
## $ SS_5yrPreDx : num [1:6683] 0.232 NA 0.302 NA 0.513 ...
## $ SS_5yrPreCensor : num [1:6683] 0.155 0.289 0.287 0.213 0.67 ...
## $ Soil_5yrPreDx : num [1:6683] 0.528 NA 0.585 NA 0.172 ...
## $ Soil_5yrPreCensor : num [1:6683] 0.428 0.545 0.374 0.248 0.161 ...PM <- PM %>% mutate_at(vars(cohort, site, dx_IPF, sex, race, dich_Race, smokeHx, status, deadORtx, dx, dx_group), as.factor)
str(PM)## tibble [6,683 × 38] (S3: tbl_df/tbl/data.frame)
## $ ID : chr [1:6683] "1097" "1405" "2796" "4742" ...
## $ cohort : Factor w/ 3 levels "CARE-PF","PFF",..: 3 3 3 3 3 3 3 3 3 3 ...
## $ site : Factor w/ 50 levels "01R","02R","03R",..: 50 50 50 50 50 50 50 50 50 50 ...
## $ dx_IPF : Factor w/ 2 levels "IPF","not_IPF": 2 2 2 2 2 2 2 2 2 2 ...
## $ dx_yr : num [1:6683] 2002 1999 2003 1999 2015 ...
## $ sex : Factor w/ 2 levels "F","M": 1 1 2 1 1 2 1 2 1 1 ...
## $ race : Factor w/ 7 levels "A","B","I","N",..: 2 7 7 7 7 7 7 7 7 7 ...
## $ dich_Race : Factor w/ 2 levels "Non-White","White": 1 2 2 2 2 2 2 2 2 2 ...
## $ smokeHx : Factor w/ 4 levels "Always","Former",..: 4 2 3 4 2 4 4 4 4 4 ...
## $ age_dx : num [1:6683] 64.4 44.7 42.3 45.5 45.2 ...
## $ disadv : num [1:6683] 0.579 0.6725 0.5949 0.5152 0.0558 ...
## $ status : Factor w/ 3 levels "0","1","2": 2 3 1 1 1 2 2 2 2 1 ...
## $ deadORtx : Factor w/ 3 levels "0","1","2": 2 2 1 1 1 2 2 2 2 1 ...
## $ dx : Factor w/ 39 levels "AEP","AFOP","AIP",..: 37 37 30 22 37 30 27 37 37 6 ...
## $ dx_group : Factor w/ 7 levels "CTD-ILD","HP",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ txed : chr [1:6683] "0" "1" "0" "0" ...
## $ tx_date : Date[1:6683], format: "NaN" "2019-04-18" ...
## $ DeathTxCensor_date: Date[1:6683], format: "2008-12-09" "2019-04-18" ...
## $ pft_date : POSIXct[1:6683], format: "2002-01-18" "1999-07-26" ...
## $ fvc_pct : num [1:6683] 31.9 53.6 82.5 47.6 62 ...
## $ dlco_pct : num [1:6683] NA 38.1 98.2 65.3 42 ...
## $ time_DeathTxCensor: num [1:6683] 6.87 18.05 20.43 19.16 1.45 ...
## $ PM_5yrPreDx : num [1:6683] 12.5 NA 14.7 NA 7.3 ...
## $ PM_5yrPreCensor : num [1:6683] 10.96 9.93 7.83 6.76 5.88 ...
## $ SO4_5yrPreDx : num [1:6683] 4.44 NA 5.86 NA 1.38 ...
## $ SO4_5yrPreCensor : num [1:6683] 3.873 2.239 1.626 1.426 0.783 ...
## $ NO3_5yrPreDx : num [1:6683] 1.388 NA 1.035 NA 0.527 ...
## $ NO3_5yrPreCensor : num [1:6683] 1.085 0.934 0.67 0.474 0.43 ...
## $ NH4_5yrPreDx : num [1:6683] 1.708 NA 2.017 NA 0.518 ...
## $ NH4_5yrPreCensor : num [1:6683] 1.49 0.786 0.483 0.374 0.139 ...
## $ BC_5yrPreDx : num [1:6683] 0.776 NA 0.861 NA 0.45 ...
## $ BC_5yrPreCensor : num [1:6683] 0.838 1.025 1.022 0.787 0.396 ...
## $ OM_5yrPreDx : num [1:6683] 2.89 NA 3.56 NA 2.05 ...
## $ OM_5yrPreCensor : num [1:6683] 3.3 3.79 3.67 3.03 1.96 ...
## $ SS_5yrPreDx : num [1:6683] 0.232 NA 0.302 NA 0.513 ...
## $ SS_5yrPreCensor : num [1:6683] 0.155 0.289 0.287 0.213 0.67 ...
## $ Soil_5yrPreDx : num [1:6683] 0.528 NA 0.585 NA 0.172 ...
## $ Soil_5yrPreCensor : num [1:6683] 0.428 0.545 0.374 0.248 0.161 ...Here I am releveling factors so that they are in an intuitive order for my later analyses.
PM$sex <- fct_relevel(PM$sex, c("M","F"))
PM$race <- fct_relevel(PM$race, c("W","B","A","N","U"))
PM$dich_Race <- fct_relevel(PM$dich_Race, c("White","Non-White"))
PM$smokeHx <- fct_relevel(PM$smokeHx, c("Never","Former","Always","Unknown"))
PM$site <- fct_relevel(PM$site, c("Simmons"))
PM$cohort <- fct_relevel(PM$cohort, c("Simmons", "PFF", "CARE-PF"))
#For dx and dx_group, I just want IPF to be first and then the rest of the categories are alphabetical
PM$dx <- fct_relevel(PM$dx, c("IPF"))
PM$dx_group <- fct_relevel(PM$dx_group, c("IPF"))
str(PM)## tibble [6,683 × 38] (S3: tbl_df/tbl/data.frame)
## $ ID : chr [1:6683] "1097" "1405" "2796" "4742" ...
## $ cohort : Factor w/ 3 levels "Simmons","PFF",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ site : Factor w/ 50 levels "Simmons","01R",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ dx_IPF : Factor w/ 2 levels "IPF","not_IPF": 2 2 2 2 2 2 2 2 2 2 ...
## $ dx_yr : num [1:6683] 2002 1999 2003 1999 2015 ...
## $ sex : Factor w/ 2 levels "M","F": 2 2 1 2 2 1 2 1 2 2 ...
## $ race : Factor w/ 7 levels "W","B","A","N",..: 2 1 1 1 1 1 1 1 1 1 ...
## $ dich_Race : Factor w/ 2 levels "White","Non-White": 2 1 1 1 1 1 1 1 1 1 ...
## $ smokeHx : Factor w/ 4 levels "Never","Former",..: 4 2 1 4 2 4 4 4 4 4 ...
## $ age_dx : num [1:6683] 64.4 44.7 42.3 45.5 45.2 ...
## $ disadv : num [1:6683] 0.579 0.6725 0.5949 0.5152 0.0558 ...
## $ status : Factor w/ 3 levels "0","1","2": 2 3 1 1 1 2 2 2 2 1 ...
## $ deadORtx : Factor w/ 3 levels "0","1","2": 2 2 1 1 1 2 2 2 2 1 ...
## $ dx : Factor w/ 39 levels "IPF","AEP","AFOP",..: 37 37 30 22 37 30 27 37 37 7 ...
## $ dx_group : Factor w/ 7 levels "IPF","CTD-ILD",..: 2 2 2 2 2 2 2 2 2 2 ...
## $ txed : chr [1:6683] "0" "1" "0" "0" ...
## $ tx_date : Date[1:6683], format: "NaN" "2019-04-18" ...
## $ DeathTxCensor_date: Date[1:6683], format: "2008-12-09" "2019-04-18" ...
## $ pft_date : POSIXct[1:6683], format: "2002-01-18" "1999-07-26" ...
## $ fvc_pct : num [1:6683] 31.9 53.6 82.5 47.6 62 ...
## $ dlco_pct : num [1:6683] NA 38.1 98.2 65.3 42 ...
## $ time_DeathTxCensor: num [1:6683] 6.87 18.05 20.43 19.16 1.45 ...
## $ PM_5yrPreDx : num [1:6683] 12.5 NA 14.7 NA 7.3 ...
## $ PM_5yrPreCensor : num [1:6683] 10.96 9.93 7.83 6.76 5.88 ...
## $ SO4_5yrPreDx : num [1:6683] 4.44 NA 5.86 NA 1.38 ...
## $ SO4_5yrPreCensor : num [1:6683] 3.873 2.239 1.626 1.426 0.783 ...
## $ NO3_5yrPreDx : num [1:6683] 1.388 NA 1.035 NA 0.527 ...
## $ NO3_5yrPreCensor : num [1:6683] 1.085 0.934 0.67 0.474 0.43 ...
## $ NH4_5yrPreDx : num [1:6683] 1.708 NA 2.017 NA 0.518 ...
## $ NH4_5yrPreCensor : num [1:6683] 1.49 0.786 0.483 0.374 0.139 ...
## $ BC_5yrPreDx : num [1:6683] 0.776 NA 0.861 NA 0.45 ...
## $ BC_5yrPreCensor : num [1:6683] 0.838 1.025 1.022 0.787 0.396 ...
## $ OM_5yrPreDx : num [1:6683] 2.89 NA 3.56 NA 2.05 ...
## $ OM_5yrPreCensor : num [1:6683] 3.3 3.79 3.67 3.03 1.96 ...
## $ SS_5yrPreDx : num [1:6683] 0.232 NA 0.302 NA 0.513 ...
## $ SS_5yrPreCensor : num [1:6683] 0.155 0.289 0.287 0.213 0.67 ...
## $ Soil_5yrPreDx : num [1:6683] 0.528 NA 0.585 NA 0.172 ...
## $ Soil_5yrPreCensor : num [1:6683] 0.428 0.545 0.374 0.248 0.161 ...Then will make a simpler dataframe that can be joined to pft
txed <- PM %>% filter(txed==1) %>% dplyr::select(ID, tx_date)
txed$ID <- as.numeric(txed$ID)
str(txed)## tibble [635 × 2] (S3: tbl_df/tbl/data.frame)
## $ ID : num [1:635] 1405 8183 8223 9946 10346 ...
## $ tx_date: Date[1:635], format: "2019-04-18" "2005-10-21" ...Next will join txed to pft
str(pft)## tibble [44,906 × 5] (S3: tbl_df/tbl/data.frame)
## $ ID : chr [1:44906] "1097" "1097" "1405" "1405" ...
## $ pft_date: Date[1:44906], format: "2002-09-26" "2002-01-18" ...
## $ fvc_pct : num [1:44906] 31.3 31.9 65.7 64.7 61.8 ...
## $ dlco_pct: num [1:44906] NA NA 39.3 47.1 41.7 ...
## $ cohort : chr [1:44906] "Simmons" "Simmons" "Simmons" "Simmons" ...pft$ID <- as.numeric(pft$ID)
pft <- left_join(pft, txed, by="ID")
#remove all pfts where pft_date>tx_date
pft <- pft %>% filter(is.na(tx_date) | pft_date<tx_date)There are some DLCO values that are too low that we need to remove. All the extremely high DLCOs have been removed that are incorrect and the remaining ones make sense.
pft <- pft %>% filter(fvc_pct>=20 & fvc_pct<=150)
summary(pft$fvc_pct)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## 20.00 58.00 71.66 72.48 86.00 150.00#FVCs look appropriate
pft <- pft %>% filter(dlco_pct>=10 & dlco_pct<=150)
summary(pft$dlco_pct)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## 10.00 39.00 52.33 54.14 67.00 150.00#DLCOs look appropriatepft$pft_id <- 1:35807Keep a simple pft dataframe
pftx <- pftPM$ID <- as.numeric(PM$ID)
pft <- left_join(pft, PM, by=c("ID", "tx_date", "cohort"))
str(pft)## tibble [35,807 × 42] (S3: tbl_df/tbl/data.frame)
## $ ID : num [1:35807] 1405 1405 1405 1405 1405 ...
## $ pft_date.x : Date[1:35807], format: "2009-11-05" "2008-07-03" ...
## $ fvc_pct.x : num [1:35807] 65.7 64.7 61.8 64.9 67.7 ...
## $ dlco_pct.x : num [1:35807] 39.3 47.1 41.7 41.8 43.2 ...
## $ cohort : chr [1:35807] "Simmons" "Simmons" "Simmons" "Simmons" ...
## $ tx_date : Date[1:35807], format: "2019-04-18" "2019-04-18" ...
## $ pft_id : int [1:35807] 1 2 3 4 5 6 7 8 9 10 ...
## $ site : Factor w/ 50 levels "Simmons","01R",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ dx_IPF : Factor w/ 2 levels "IPF","not_IPF": 2 2 2 2 2 2 2 2 2 2 ...
## $ dx_yr : num [1:35807] 1999 1999 1999 1999 1999 ...
## $ sex : Factor w/ 2 levels "M","F": 2 2 2 2 2 2 2 2 2 2 ...
## $ race : Factor w/ 7 levels "W","B","A","N",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ dich_Race : Factor w/ 2 levels "White","Non-White": 1 1 1 1 1 1 1 1 1 1 ...
## $ smokeHx : Factor w/ 4 levels "Never","Former",..: 2 2 2 2 2 2 2 2 2 2 ...
## $ age_dx : num [1:35807] 44.7 44.7 44.7 44.7 44.7 ...
## $ disadv : num [1:35807] 0.672 0.672 0.672 0.672 0.672 ...
## $ status : Factor w/ 3 levels "0","1","2": 3 3 3 3 3 3 3 3 3 3 ...
## $ deadORtx : Factor w/ 3 levels "0","1","2": 2 2 2 2 2 2 2 2 2 2 ...
## $ dx : Factor w/ 39 levels "IPF","AEP","AFOP",..: 37 37 37 37 37 37 37 37 37 37 ...
## $ dx_group : Factor w/ 7 levels "IPF","CTD-ILD",..: 2 2 2 2 2 2 2 2 2 2 ...
## $ txed : chr [1:35807] "1" "1" "1" "1" ...
## $ DeathTxCensor_date: Date[1:35807], format: "2019-04-18" "2019-04-18" ...
## $ pft_date.y : POSIXct[1:35807], format: "1999-07-26" "1999-07-26" ...
## $ fvc_pct.y : num [1:35807] 53.6 53.6 53.6 53.6 53.6 ...
## $ dlco_pct.y : num [1:35807] 38.1 38.1 38.1 38.1 38.1 ...
## $ time_DeathTxCensor: num [1:35807] 18 18 18 18 18 ...
## $ PM_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ PM_5yrPreCensor : num [1:35807] 9.93 9.93 9.93 9.93 9.93 ...
## $ SO4_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ SO4_5yrPreCensor : num [1:35807] 2.24 2.24 2.24 2.24 2.24 ...
## $ NO3_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ NO3_5yrPreCensor : num [1:35807] 0.934 0.934 0.934 0.934 0.934 ...
## $ NH4_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ NH4_5yrPreCensor : num [1:35807] 0.786 0.786 0.786 0.786 0.786 ...
## $ BC_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ BC_5yrPreCensor : num [1:35807] 1.02 1.02 1.02 1.02 1.02 ...
## $ OM_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ OM_5yrPreCensor : num [1:35807] 3.79 3.79 3.79 3.79 3.79 ...
## $ SS_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ SS_5yrPreCensor : num [1:35807] 0.289 0.289 0.289 0.289 0.289 ...
## $ Soil_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ Soil_5yrPreCensor : num [1:35807] 0.545 0.545 0.545 0.545 0.545 ...pft <- pft %>% rename("pft_date"="pft_date.x", "fvc_pct"="fvc_pct.x", "dlco_pct"="dlco_pct.x", "first_pft_date"="pft_date.y", "first_fvc_pct"="fvc_pct.y", "first_dlco_pct"="dlco_pct.y")
pft$ID <- as.factor(pft$ID)
str(pft)## tibble [35,807 × 42] (S3: tbl_df/tbl/data.frame)
## $ ID : Factor w/ 6162 levels "1405","2055",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ pft_date : Date[1:35807], format: "2009-11-05" "2008-07-03" ...
## $ fvc_pct : num [1:35807] 65.7 64.7 61.8 64.9 67.7 ...
## $ dlco_pct : num [1:35807] 39.3 47.1 41.7 41.8 43.2 ...
## $ cohort : chr [1:35807] "Simmons" "Simmons" "Simmons" "Simmons" ...
## $ tx_date : Date[1:35807], format: "2019-04-18" "2019-04-18" ...
## $ pft_id : int [1:35807] 1 2 3 4 5 6 7 8 9 10 ...
## $ site : Factor w/ 50 levels "Simmons","01R",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ dx_IPF : Factor w/ 2 levels "IPF","not_IPF": 2 2 2 2 2 2 2 2 2 2 ...
## $ dx_yr : num [1:35807] 1999 1999 1999 1999 1999 ...
## $ sex : Factor w/ 2 levels "M","F": 2 2 2 2 2 2 2 2 2 2 ...
## $ race : Factor w/ 7 levels "W","B","A","N",..: 1 1 1 1 1 1 1 1 1 1 ...
## $ dich_Race : Factor w/ 2 levels "White","Non-White": 1 1 1 1 1 1 1 1 1 1 ...
## $ smokeHx : Factor w/ 4 levels "Never","Former",..: 2 2 2 2 2 2 2 2 2 2 ...
## $ age_dx : num [1:35807] 44.7 44.7 44.7 44.7 44.7 ...
## $ disadv : num [1:35807] 0.672 0.672 0.672 0.672 0.672 ...
## $ status : Factor w/ 3 levels "0","1","2": 3 3 3 3 3 3 3 3 3 3 ...
## $ deadORtx : Factor w/ 3 levels "0","1","2": 2 2 2 2 2 2 2 2 2 2 ...
## $ dx : Factor w/ 39 levels "IPF","AEP","AFOP",..: 37 37 37 37 37 37 37 37 37 37 ...
## $ dx_group : Factor w/ 7 levels "IPF","CTD-ILD",..: 2 2 2 2 2 2 2 2 2 2 ...
## $ txed : chr [1:35807] "1" "1" "1" "1" ...
## $ DeathTxCensor_date: Date[1:35807], format: "2019-04-18" "2019-04-18" ...
## $ first_pft_date : POSIXct[1:35807], format: "1999-07-26" "1999-07-26" ...
## $ first_fvc_pct : num [1:35807] 53.6 53.6 53.6 53.6 53.6 ...
## $ first_dlco_pct : num [1:35807] 38.1 38.1 38.1 38.1 38.1 ...
## $ time_DeathTxCensor: num [1:35807] 18 18 18 18 18 ...
## $ PM_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ PM_5yrPreCensor : num [1:35807] 9.93 9.93 9.93 9.93 9.93 ...
## $ SO4_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ SO4_5yrPreCensor : num [1:35807] 2.24 2.24 2.24 2.24 2.24 ...
## $ NO3_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ NO3_5yrPreCensor : num [1:35807] 0.934 0.934 0.934 0.934 0.934 ...
## $ NH4_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ NH4_5yrPreCensor : num [1:35807] 0.786 0.786 0.786 0.786 0.786 ...
## $ BC_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ BC_5yrPreCensor : num [1:35807] 1.02 1.02 1.02 1.02 1.02 ...
## $ OM_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ OM_5yrPreCensor : num [1:35807] 3.79 3.79 3.79 3.79 3.79 ...
## $ SS_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ SS_5yrPreCensor : num [1:35807] 0.289 0.289 0.289 0.289 0.289 ...
## $ Soil_5yrPreDx : num [1:35807] NA NA NA NA NA NA NA NA NA NA ...
## $ Soil_5yrPreCensor : num [1:35807] 0.545 0.545 0.545 0.545 0.545 ...pft$first_pft_date <- as.Date(pft$first_pft_date)
pft <- pft %>% mutate(time_firstPFT=(pft_date-first_pft_date)/365.25)
pft$time_firstPFT <- as.numeric(pft$time_firstPFT)
pft <- pft %>% filter(time_firstPFT>=0)
summary(pft$time_firstPFT)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## 0.0000 0.2875 0.9993 1.5113 2.1006 17.9083#Now there are no negative time_firstPFTs
summary(pft$fvc_pct)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## 22.94 48.12 58.00 59.92 70.00 125.00summary(pft$dlco_pct)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## 10.35 28.00 37.00 38.88 47.07 100.04#And the breakdowns of fvc_pct and dlco_pct make sense#Look at the mean and total variance of fvc_pct
pft %>% summarise(mean_fvc=mean(fvc_pct, na.rm=T))## # A tibble: 1 × 1
## mean_fvc
## <dbl>
## 1 59.9tot_var_fvc <- pft %>% dplyr::select(fvc_pct) %>% summarise(var_fvc_pct=var(fvc_pct, na.rm=T))
tot_var_fvc## # A tibble: 1 × 1
## var_fvc_pct
## <dbl>
## 1 287.#Look at the between subject variance
bw_subj_var_fvc <- pft %>% group_by(ID) %>% mutate(mean_fvc_pct=mean(fvc_pct)) %>% ungroup() %>% summarise(bw_subj_var_fvc=var(mean_fvc_pct, na.rm=T))
bw_subj_var_fvc## # A tibble: 1 × 1
## bw_subj_var_fvc
## <dbl>
## 1 247.fvc_ICC <- bw_subj_var_fvc/tot_var_fvc
fvc_ICC## bw_subj_var_fvc
## 1 0.8605219fvc_ICC=0.86 indicates that ~86% of the variance is between subject variance. I.e. there is more difference in fvc_pct between patients than within any single patient.
n_pfts <- pft %>% count(ID)
n_pfts## # A tibble: 463 × 2
## ID n
## <fct> <int>
## 1 1405 31
## 2 2055 1
## 3 3227 8
## 4 7702 8
## 5 7899 3
## 6 8180 11
## 7 8183 13
## 8 8336 6
## 9 8401 17
## 10 8565 1
## # … with 453 more rowssummary(n_pfts$n)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## 1.000 2.000 4.000 4.687 6.000 31.000#This shows that the median # of PFTs is 4 and the mean is 6Median number of PFTs 4 and mean is 5
Linear mixed models with random intercept and slope will be used to evaluate the impact of PM During Disease on FVC decline.
FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*PM_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14380.1
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2919 -0.4350 -0.0175 0.4454 4.5608
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 255.00 15.969
## time_firstPFT 12.79 3.577 -0.09
## Residual 25.72 5.072
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 65.1053 5.4154 12.022
## time_firstPFT -6.6677 2.1626 -3.083
## PM_5yrPreDx -0.4650 0.4310 -1.079
## site02R -9.3630 16.8437 -0.556
## site03R 11.6036 12.2046 0.951
## site04R 2.5025 11.7455 0.213
## site05R -11.3979 9.6903 -1.176
## site06R 19.3613 11.9432 1.621
## site07R 11.1271 4.9688 2.239
## site09R 20.0243 11.9066 1.682
## site101 0.8794 3.9237 0.224
## site102 7.9901 6.9880 1.143
## site103 -3.9310 3.9802 -0.988
## site104 -8.8228 7.1920 -1.227
## site105 2.6759 3.6711 0.729
## site106 -5.6054 4.5163 -1.241
## site107 -6.4709 11.9787 -0.540
## site108 -3.1692 10.1148 -0.313
## site10R 14.7520 17.5760 0.839
## site11R 19.4776 8.3181 2.342
## site12R 9.7173 11.9076 0.816
## site13R 14.4479 8.9573 1.613
## site14R 5.2409 15.0714 0.348
## site15R -27.9343 16.8079 -1.662
## site16R -15.6742 7.4996 -2.090
## site17R 4.6738 16.8476 0.277
## site18R -0.8121 11.9810 -0.068
## site19R 6.8155 7.5261 0.906
## site20R 2.2080 7.0736 0.312
## site21R 3.5426 16.3628 0.217
## site22R 0.1035 5.3776 0.019
## site23R -11.9555 7.7053 -1.552
## site24R 4.3835 6.5669 0.668
## site25R 0.2292 7.0639 0.032
## site28R 0.9515 9.7563 0.098
## site29R -5.5806 16.7328 -0.334
## site31R 2.4054 7.6111 0.316
## site32R 10.2468 8.5735 1.195
## site33R -17.1743 8.4739 -2.027
## site34R 0.4184 6.6655 0.063
## site35R 3.2543 10.0620 0.323
## site36R -13.0811 7.5312 -1.737
## site37R 11.9873 8.3529 1.435
## site38R 11.3550 5.7517 1.974
## site39R 15.6427 16.8677 0.927
## site40R 27.9128 11.7589 2.374
## site41R -2.4404 9.7893 -0.249
## site42R -1.1891 5.2655 -0.226
## time_firstPFT:PM_5yrPreDx 0.1928 0.1665 1.158
## time_firstPFT:site02R -14.2766 14.7635 -0.967
## time_firstPFT:site03R 2.6688 5.0844 0.525
## time_firstPFT:site04R -4.5206 5.5208 -0.819
## time_firstPFT:site05R -0.5836 6.2169 -0.094
## time_firstPFT:site06R -2.5952 4.7856 -0.542
## time_firstPFT:site07R -3.0610 1.5319 -1.998
## time_firstPFT:site09R -5.6165 4.2493 -1.322
## time_firstPFT:site101 0.3735 1.3987 0.267
## time_firstPFT:site102 -1.1758 2.3678 -0.497
## time_firstPFT:site103 3.3199 1.4959 2.219
## time_firstPFT:site104 7.9567 3.6643 2.171
## time_firstPFT:site105 0.5738 1.2808 0.448
## time_firstPFT:site106 3.0342 1.7485 1.735
## time_firstPFT:site107 8.5241 6.7309 1.266
## time_firstPFT:site108 8.1962 3.3197 2.469
## time_firstPFT:site11R 3.7310 2.7811 1.342
## time_firstPFT:site12R 0.3908 4.0947 0.095
## time_firstPFT:site13R -1.0332 4.0539 -0.255
## time_firstPFT:site14R 3.9947 18.9739 0.211
## time_firstPFT:site15R -2.6103 11.3750 -0.229
## time_firstPFT:site16R 3.0319 2.6593 1.140
## time_firstPFT:site18R 7.2911 10.8025 0.675
## time_firstPFT:site19R 0.3890 3.2535 0.120
## time_firstPFT:site20R 1.7094 3.2162 0.532
## time_firstPFT:site21R 4.8205 4.4741 1.077
## time_firstPFT:site22R -2.8819 2.6935 -1.070
## time_firstPFT:site23R 2.2615 5.0387 0.449
## time_firstPFT:site24R 0.9041 2.4101 0.375
## time_firstPFT:site25R -5.5122 2.8020 -1.967
## time_firstPFT:site28R -11.1407 10.9850 -1.014
## time_firstPFT:site29R 0.3493 4.7405 0.074
## time_firstPFT:site31R 1.6293 2.0578 0.792
## time_firstPFT:site32R -3.2815 3.3034 -0.993
## time_firstPFT:site33R 3.9039 3.8649 1.010
## time_firstPFT:site34R 0.5002 2.4635 0.203
## time_firstPFT:site35R 13.1348 4.2784 3.070
## time_firstPFT:site36R 3.6283 2.8177 1.288
## time_firstPFT:site37R -1.8727 2.7358 -0.685
## time_firstPFT:site38R -2.3734 1.9081 -1.244
## time_firstPFT:site39R -44.6861 8.6229 -5.182
## time_firstPFT:site40R 1.0647 4.5086 0.236
## time_firstPFT:site41R 2.0018 5.5583 0.360
## time_firstPFT:site42R 1.7412 5.4047 0.322##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.740report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## PM_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 65.11 (95% CI [54.49,
## 75.73], t(2038) = 12.02, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-10.91, -2.43], t(2038) = -3.08, p = 0.002; Std. beta = -0.45,
## 95% CI [-0.57, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.46, 95% CI [-1.31, 0.38], t(2038) = -1.08, p = 0.281; Std. beta = -0.04,
## 95% CI [-0.21, 0.14])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-42.40, 23.67], t(2038) = -0.56, p = 0.578; Std. beta = -1.75,
## 95% CI [-4.45, 0.95])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.60, 95% CI [-12.33, 35.54], t(2038) = 0.95, p = 0.342; Std. beta = 0.90,
## 95% CI [-0.52, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-20.53, 25.54], t(2038) = 0.21, p = 0.831; Std. beta = -0.23,
## 95% CI [-1.72, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.40, 95% CI [-30.40, 7.61], t(2038) = -1.18, p = 0.240; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.36, 95% CI [-4.06, 42.78], t(2038) = 1.62, p = 0.105; Std. beta = 0.92,
## 95% CI [-0.56, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.13, 95% CI [1.38, 20.87], t(2038) = 2.24, p = 0.025; Std. beta = 0.40, 95%
## CI [-0.19, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.02, 95% CI [-3.33, 43.37], t(2038) = 1.68, p = 0.093; Std. beta = 0.70,
## 95% CI [-0.75, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-6.82, 8.57], t(2038) = 0.22, p = 0.823; Std. beta = 0.08, 95%
## CI [-0.39, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.99, 95% CI [-5.71, 21.69], t(2038) = 1.14, p = 0.253; Std. beta = 0.37, 95%
## CI [-0.46, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-11.74, 3.87], t(2038) = -0.99, p = 0.323; Std. beta = 0.05,
## 95% CI [-0.44, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.82, 95% CI [-22.93, 5.28], t(2038) = -1.23, p = 0.220; Std. beta = 0.15,
## 95% CI [-0.80, 1.10])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-4.52, 9.88], t(2038) = 0.73, p = 0.466; Std. beta = 0.21, 95%
## CI [-0.24, 0.65])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.61, 95% CI [-14.46, 3.25], t(2038) = -1.24, p = 0.215; Std. beta = -0.07,
## 95% CI [-0.61, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.47, 95% CI [-29.96, 17.02], t(2038) = -0.54, p = 0.589; Std. beta = 0.34,
## 95% CI [-1.22, 1.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-23.01, 16.67], t(2038) = -0.31, p = 0.754; Std. beta = 0.50,
## 95% CI [-0.69, 1.69])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.75, 95% CI [-19.72, 49.22], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.16, 2.89])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.48, 95% CI [3.16, 35.79], t(2038) = 2.34, p = 0.019; Std. beta = 1.46, 95%
## CI [0.46, 2.45])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-13.64, 33.07], t(2038) = 0.82, p = 0.415; Std. beta = 0.60,
## 95% CI [-0.85, 2.06])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.45, 95% CI [-3.12, 32.01], t(2038) = 1.61, p = 0.107; Std. beta = 0.76,
## 95% CI [-0.30, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-24.32, 34.80], t(2038) = 0.35, p = 0.728; Std. beta = 0.64,
## 95% CI [-1.83, 3.11])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.93, 95% CI [-60.90, 5.03], t(2038) = -1.66, p = 0.097; Std. beta = -1.86,
## 95% CI [-4.17, 0.46])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.67, 95% CI [-30.38, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.58, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.67, 95% CI [-28.37, 37.71], t(2038) = 0.28, p = 0.781; Std. beta = 0.27,
## 95% CI [-1.66, 2.21])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-24.31, 22.68], t(2038) = -0.07, p = 0.946; Std. beta = 0.57,
## 95% CI [-1.48, 2.61])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-7.94, 21.58], t(2038) = 0.91, p = 0.365; Std. beta = 0.43, 95%
## CI [-0.50, 1.37])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-11.66, 16.08], t(2038) = 0.31, p = 0.755; Std. beta = 0.27,
## 95% CI [-0.61, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-28.55, 35.63], t(2038) = 0.22, p = 0.829; Std. beta = 0.61,
## 95% CI [-1.29, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.10, 95% CI [-10.44, 10.65], t(2038) = 0.02, p = 0.985; Std. beta = -0.24,
## 95% CI [-0.92, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.96, 95% CI [-27.07, 3.16], t(2038) = -1.55, p = 0.121; Std. beta = -0.51,
## 95% CI [-1.63, 0.61])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-8.49, 17.26], t(2038) = 0.67, p = 0.505; Std. beta = 0.33, 95%
## CI [-0.45, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-13.62, 14.08], t(2038) = 0.03, p = 0.974; Std. beta = -0.45,
## 95% CI [-1.30, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.18, 20.08], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.58, 95% CI [-38.40, 27.23], t(2038) = -0.33, p = 0.739; Std. beta = -0.30,
## 95% CI [-2.22, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-12.52, 17.33], t(2038) = 0.32, p = 0.752; Std. beta = 0.28,
## 95% CI [-0.61, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-6.57, 27.06], t(2038) = 1.20, p = 0.232; Std. beta = 0.32,
## 95% CI [-0.72, 1.37])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.17, 95% CI [-33.79, -0.56], t(2038) = -2.03, p = 0.043; Std. beta = -0.68,
## 95% CI [-1.77, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.42, 95% CI [-12.65, 13.49], t(2038) = 0.06, p = 0.950; Std. beta = 0.07,
## 95% CI [-0.74, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.25, 95% CI [-16.48, 22.99], t(2038) = 0.32, p = 0.746; Std. beta = 1.30,
## 95% CI [0.07, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-27.85, 1.69], t(2038) = -1.74, p = 0.083; Std. beta = -0.46,
## 95% CI [-1.39, 0.46])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.99, 95% CI [-4.39, 28.37], t(2038) = 1.44, p = 0.151; Std. beta = 0.55,
## 95% CI [-0.44, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.36, 95% CI [0.08, 22.63], t(2038) = 1.97, p = 0.048; Std. beta = 0.47, 95%
## CI [-0.22, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.64, 95% CI [-17.44, 48.72], t(2038) = 0.93, p = 0.354; Std. beta = -2.84,
## 95% CI [-4.98, -0.70])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [4.85, 50.97], t(2038) = 2.37, p = 0.018; Std. beta = 1.73, 95%
## CI [0.26, 3.19])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-21.64, 16.76], t(2038) = -0.25, p = 0.803; Std. beta = 0.03,
## 95% CI [-1.27, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.19, 95% CI [-11.52, 9.14], t(2038) = -0.23, p = 0.821; Std. beta = 0.08,
## 95% CI [-0.85, 1.00])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.19, 95% CI [-0.13, 0.52], t(2038) = 1.16, p = 0.247;
## Std. beta = 0.06, 95% CI [-0.04, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.28, 95% CI [-43.23, 14.68], t(2038) = -0.97, p = 0.334;
## Std. beta = -1.33, 95% CI [-4.03, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.67, 95% CI [-7.30, 12.64], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.25, 95% CI [-0.68, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.52, 95% CI [-15.35, 6.31], t(2038) = -0.82, p = 0.413; Std.
## beta = -0.42, 95% CI [-1.43, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-12.78, 11.61], t(2038) = -0.09, p = 0.925;
## Std. beta = -0.05, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-11.98, 6.79], t(2038) = -0.54, p = 0.588; Std.
## beta = -0.24, 95% CI [-1.12, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.06, 95% CI [-6.07, -0.06], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.29, 95% CI [-0.57, -5.30e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.62, 95% CI [-13.95, 2.72], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.52, 95% CI [-1.30, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-2.37, 3.12], t(2038) = 0.27, p = 0.789; Std.
## beta = 0.03, 95% CI [-0.22, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-5.82, 3.47], t(2038) = -0.50, p = 0.620; Std.
## beta = -0.11, 95% CI [-0.54, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.32, 95% CI [0.39, 6.25], t(2038) = 2.22, p = 0.027; Std.
## beta = 0.31, 95% CI [0.04, 0.58])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.96, 95% CI [0.77, 15.14], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.74, 95% CI [0.07, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-1.94, 3.09], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.05, 95% CI [-0.18, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.39, 6.46], t(2038) = 1.74, p = 0.083; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.52, 95% CI [-4.68, 21.72], t(2038) = 1.27, p = 0.206; Std.
## beta = 0.79, 95% CI [-0.44, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.20, 95% CI [1.69, 14.71], t(2038) = 2.47, p = 0.014; Std.
## beta = 0.76, 95% CI [0.16, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-1.72, 9.19], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.35, 95% CI [-0.16, 0.86])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-7.64, 8.42], t(2038) = 0.10, p = 0.924; Std.
## beta = 0.04, 95% CI [-0.71, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-8.98, 6.92], t(2038) = -0.25, p = 0.799; Std.
## beta = -0.10, 95% CI [-0.84, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-33.22, 41.21], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-24.92, 19.70], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-2.18, 8.25], t(2038) = 1.14, p = 0.254; Std.
## beta = 0.28, 95% CI [-0.20, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.29, 95% CI [-13.89, 28.48], t(2038) = 0.67, p = 0.500; Std.
## beta = 0.68, 95% CI [-1.30, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-5.99, 6.77], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.56, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-4.60, 8.02], t(2038) = 0.53, p = 0.595; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.82, 95% CI [-3.95, 13.59], t(2038) = 1.08, p = 0.281; Std.
## beta = 0.45, 95% CI [-0.37, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-8.16, 2.40], t(2038) = -1.07, p = 0.285; Std.
## beta = -0.27, 95% CI [-0.76, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-7.62, 12.14], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.21, 95% CI [-0.71, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-3.82, 5.63], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.08, 95% CI [-0.36, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.51, 95% CI [-11.01, -0.02], t(2038) = -1.97, p = 0.049;
## Std. beta = -0.51, 95% CI [-1.03, -1.60e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.14, 95% CI [-32.68, 10.40], t(2038) = -1.01, p = 0.311;
## Std. beta = -1.04, 95% CI [-3.05, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.35, 95% CI [-8.95, 9.65], t(2038) = 0.07, p = 0.941; Std.
## beta = 0.03, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.63, 95% CI [-2.41, 5.66], t(2038) = 0.79, p = 0.429; Std.
## beta = 0.15, 95% CI [-0.22, 0.53])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.76, 3.20], t(2038) = -0.99, p = 0.321; Std.
## beta = -0.31, 95% CI [-0.91, 0.30])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-3.68, 11.48], t(2038) = 1.01, p = 0.313; Std.
## beta = 0.36, 95% CI [-0.34, 1.07])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-4.33, 5.33], t(2038) = 0.20, p = 0.839; Std.
## beta = 0.05, 95% CI [-0.40, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.13, 95% CI [4.74, 21.53], t(2038) = 3.07, p = 0.002; Std.
## beta = 1.22, 95% CI [0.44, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-1.90, 9.15], t(2038) = 1.29, p = 0.198; Std.
## beta = 0.34, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-7.24, 3.49], t(2038) = -0.68, p = 0.494; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-6.12, 1.37], t(2038) = -1.24, p = 0.214; Std.
## beta = -0.22, 95% CI [-0.57, 0.13])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.69, 95% CI [-61.60, -27.78], t(2038) = -5.18, p < .001;
## Std. beta = -4.17, 95% CI [-5.74, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.78, 9.91], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.10, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.90, 12.90], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.19, 95% CI [-0.83, 1.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.86, 12.34], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.16, 95% CI [-0.83, 1.15])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## PM_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to
## PM_5yrPreDx = 0, is at 65.11 (95% CI [54.49, 75.73], t(2038) = 12.02, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-10.91, -2.43], t(2038) = -3.08, p = 0.002; Std. beta = -0.45,
## 95% CI [-0.57, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.46, 95% CI [-1.31, 0.38], t(2038) = -1.08, p = 0.281; Std. beta = -0.04,
## 95% CI [-0.21, 0.14])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-42.40, 23.67], t(2038) = -0.56, p = 0.578; Std. beta = -1.75,
## 95% CI [-4.45, 0.95])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.60, 95% CI [-12.33, 35.54], t(2038) = 0.95, p = 0.342; Std. beta = 0.90,
## 95% CI [-0.52, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-20.53, 25.54], t(2038) = 0.21, p = 0.831; Std. beta = -0.23,
## 95% CI [-1.72, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.40, 95% CI [-30.40, 7.61], t(2038) = -1.18, p = 0.240; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.36, 95% CI [-4.06, 42.78], t(2038) = 1.62, p = 0.105; Std. beta = 0.92,
## 95% CI [-0.56, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.13, 95% CI [1.38, 20.87], t(2038) = 2.24, p = 0.025; Std. beta = 0.40, 95%
## CI [-0.19, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.02, 95% CI [-3.33, 43.37], t(2038) = 1.68, p = 0.093; Std. beta = 0.70,
## 95% CI [-0.75, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-6.82, 8.57], t(2038) = 0.22, p = 0.823; Std. beta = 0.08, 95%
## CI [-0.39, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.99, 95% CI [-5.71, 21.69], t(2038) = 1.14, p = 0.253; Std. beta = 0.37, 95%
## CI [-0.46, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-11.74, 3.87], t(2038) = -0.99, p = 0.323; Std. beta = 0.05,
## 95% CI [-0.44, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.82, 95% CI [-22.93, 5.28], t(2038) = -1.23, p = 0.220; Std. beta = 0.15,
## 95% CI [-0.80, 1.10])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-4.52, 9.88], t(2038) = 0.73, p = 0.466; Std. beta = 0.21, 95%
## CI [-0.24, 0.65])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.61, 95% CI [-14.46, 3.25], t(2038) = -1.24, p = 0.215; Std. beta = -0.07,
## 95% CI [-0.61, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.47, 95% CI [-29.96, 17.02], t(2038) = -0.54, p = 0.589; Std. beta = 0.34,
## 95% CI [-1.22, 1.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-23.01, 16.67], t(2038) = -0.31, p = 0.754; Std. beta = 0.50,
## 95% CI [-0.69, 1.69])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.75, 95% CI [-19.72, 49.22], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.16, 2.89])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.48, 95% CI [3.16, 35.79], t(2038) = 2.34, p = 0.019; Std. beta = 1.46, 95%
## CI [0.46, 2.45])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-13.64, 33.07], t(2038) = 0.82, p = 0.415; Std. beta = 0.60,
## 95% CI [-0.85, 2.06])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.45, 95% CI [-3.12, 32.01], t(2038) = 1.61, p = 0.107; Std. beta = 0.76,
## 95% CI [-0.30, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-24.32, 34.80], t(2038) = 0.35, p = 0.728; Std. beta = 0.64,
## 95% CI [-1.83, 3.11])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.93, 95% CI [-60.90, 5.03], t(2038) = -1.66, p = 0.097; Std. beta = -1.86,
## 95% CI [-4.17, 0.46])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.67, 95% CI [-30.38, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.58, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.67, 95% CI [-28.37, 37.71], t(2038) = 0.28, p = 0.781; Std. beta = 0.27,
## 95% CI [-1.66, 2.21])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-24.31, 22.68], t(2038) = -0.07, p = 0.946; Std. beta = 0.57,
## 95% CI [-1.48, 2.61])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-7.94, 21.58], t(2038) = 0.91, p = 0.365; Std. beta = 0.43, 95%
## CI [-0.50, 1.37])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-11.66, 16.08], t(2038) = 0.31, p = 0.755; Std. beta = 0.27,
## 95% CI [-0.61, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-28.55, 35.63], t(2038) = 0.22, p = 0.829; Std. beta = 0.61,
## 95% CI [-1.29, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.10, 95% CI [-10.44, 10.65], t(2038) = 0.02, p = 0.985; Std. beta = -0.24,
## 95% CI [-0.92, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.96, 95% CI [-27.07, 3.16], t(2038) = -1.55, p = 0.121; Std. beta = -0.51,
## 95% CI [-1.63, 0.61])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-8.49, 17.26], t(2038) = 0.67, p = 0.505; Std. beta = 0.33, 95%
## CI [-0.45, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-13.62, 14.08], t(2038) = 0.03, p = 0.974; Std. beta = -0.45,
## 95% CI [-1.30, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.18, 20.08], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.58, 95% CI [-38.40, 27.23], t(2038) = -0.33, p = 0.739; Std. beta = -0.30,
## 95% CI [-2.22, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-12.52, 17.33], t(2038) = 0.32, p = 0.752; Std. beta = 0.28,
## 95% CI [-0.61, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-6.57, 27.06], t(2038) = 1.20, p = 0.232; Std. beta = 0.32,
## 95% CI [-0.72, 1.37])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.17, 95% CI [-33.79, -0.56], t(2038) = -2.03, p = 0.043; Std. beta = -0.68,
## 95% CI [-1.77, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.42, 95% CI [-12.65, 13.49], t(2038) = 0.06, p = 0.950; Std. beta = 0.07,
## 95% CI [-0.74, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.25, 95% CI [-16.48, 22.99], t(2038) = 0.32, p = 0.746; Std. beta = 1.30,
## 95% CI [0.07, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-27.85, 1.69], t(2038) = -1.74, p = 0.083; Std. beta = -0.46,
## 95% CI [-1.39, 0.46])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.99, 95% CI [-4.39, 28.37], t(2038) = 1.44, p = 0.151; Std. beta = 0.55,
## 95% CI [-0.44, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.36, 95% CI [0.08, 22.63], t(2038) = 1.97, p = 0.048; Std. beta = 0.47, 95%
## CI [-0.22, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.64, 95% CI [-17.44, 48.72], t(2038) = 0.93, p = 0.354; Std. beta = -2.84,
## 95% CI [-4.98, -0.70])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [4.85, 50.97], t(2038) = 2.37, p = 0.018; Std. beta = 1.73, 95%
## CI [0.26, 3.19])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-21.64, 16.76], t(2038) = -0.25, p = 0.803; Std. beta = 0.03,
## 95% CI [-1.27, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.19, 95% CI [-11.52, 9.14], t(2038) = -0.23, p = 0.821; Std. beta = 0.08,
## 95% CI [-0.85, 1.00])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.19, 95% CI [-0.13, 0.52], t(2038) = 1.16, p = 0.247;
## Std. beta = 0.06, 95% CI [-0.04, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.28, 95% CI [-43.23, 14.68], t(2038) = -0.97, p = 0.334;
## Std. beta = -1.33, 95% CI [-4.03, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.67, 95% CI [-7.30, 12.64], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.25, 95% CI [-0.68, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.52, 95% CI [-15.35, 6.31], t(2038) = -0.82, p = 0.413; Std.
## beta = -0.42, 95% CI [-1.43, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-12.78, 11.61], t(2038) = -0.09, p = 0.925;
## Std. beta = -0.05, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-11.98, 6.79], t(2038) = -0.54, p = 0.588; Std.
## beta = -0.24, 95% CI [-1.12, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.06, 95% CI [-6.07, -0.06], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.29, 95% CI [-0.57, -5.30e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.62, 95% CI [-13.95, 2.72], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.52, 95% CI [-1.30, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-2.37, 3.12], t(2038) = 0.27, p = 0.789; Std.
## beta = 0.03, 95% CI [-0.22, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-5.82, 3.47], t(2038) = -0.50, p = 0.620; Std.
## beta = -0.11, 95% CI [-0.54, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.32, 95% CI [0.39, 6.25], t(2038) = 2.22, p = 0.027; Std.
## beta = 0.31, 95% CI [0.04, 0.58])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.96, 95% CI [0.77, 15.14], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.74, 95% CI [0.07, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-1.94, 3.09], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.05, 95% CI [-0.18, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.39, 6.46], t(2038) = 1.74, p = 0.083; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.52, 95% CI [-4.68, 21.72], t(2038) = 1.27, p = 0.206; Std.
## beta = 0.79, 95% CI [-0.44, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.20, 95% CI [1.69, 14.71], t(2038) = 2.47, p = 0.014; Std.
## beta = 0.76, 95% CI [0.16, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-1.72, 9.19], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.35, 95% CI [-0.16, 0.86])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-7.64, 8.42], t(2038) = 0.10, p = 0.924; Std.
## beta = 0.04, 95% CI [-0.71, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-8.98, 6.92], t(2038) = -0.25, p = 0.799; Std.
## beta = -0.10, 95% CI [-0.84, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-33.22, 41.21], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-24.92, 19.70], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-2.18, 8.25], t(2038) = 1.14, p = 0.254; Std.
## beta = 0.28, 95% CI [-0.20, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.29, 95% CI [-13.89, 28.48], t(2038) = 0.67, p = 0.500; Std.
## beta = 0.68, 95% CI [-1.30, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-5.99, 6.77], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.56, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-4.60, 8.02], t(2038) = 0.53, p = 0.595; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.82, 95% CI [-3.95, 13.59], t(2038) = 1.08, p = 0.281; Std.
## beta = 0.45, 95% CI [-0.37, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-8.16, 2.40], t(2038) = -1.07, p = 0.285; Std.
## beta = -0.27, 95% CI [-0.76, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-7.62, 12.14], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.21, 95% CI [-0.71, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-3.82, 5.63], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.08, 95% CI [-0.36, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.51, 95% CI [-11.01, -0.02], t(2038) = -1.97, p = 0.049;
## Std. beta = -0.51, 95% CI [-1.03, -1.60e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.14, 95% CI [-32.68, 10.40], t(2038) = -1.01, p = 0.311;
## Std. beta = -1.04, 95% CI [-3.05, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.35, 95% CI [-8.95, 9.65], t(2038) = 0.07, p = 0.941; Std.
## beta = 0.03, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.63, 95% CI [-2.41, 5.66], t(2038) = 0.79, p = 0.429; Std.
## beta = 0.15, 95% CI [-0.22, 0.53])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.76, 3.20], t(2038) = -0.99, p = 0.321; Std.
## beta = -0.31, 95% CI [-0.91, 0.30])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-3.68, 11.48], t(2038) = 1.01, p = 0.313; Std.
## beta = 0.36, 95% CI [-0.34, 1.07])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-4.33, 5.33], t(2038) = 0.20, p = 0.839; Std.
## beta = 0.05, 95% CI [-0.40, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.13, 95% CI [4.74, 21.53], t(2038) = 3.07, p = 0.002; Std.
## beta = 1.22, 95% CI [0.44, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-1.90, 9.15], t(2038) = 1.29, p = 0.198; Std.
## beta = 0.34, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-7.24, 3.49], t(2038) = -0.68, p = 0.494; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-6.12, 1.37], t(2038) = -1.24, p = 0.214; Std.
## beta = -0.22, 95% CI [-0.57, 0.13])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.69, 95% CI [-61.60, -27.78], t(2038) = -5.18, p < .001;
## Std. beta = -4.17, 95% CI [-5.74, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.78, 9.91], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.10, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.90, 12.90], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.19, 95% CI [-0.83, 1.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.86, 12.34], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.16, 95% CI [-0.83, 1.15])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT * site
## + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 65.11 (95% CI [54.49, 75.73], t(2038) = 12.02, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-10.91, -2.43], t(2038) = -3.08, p = 0.002; Std. beta = -0.45,
## 95% CI [-0.57, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.46, 95% CI [-1.31, 0.38], t(2038) = -1.08, p = 0.281; Std. beta = -0.04,
## 95% CI [-0.21, 0.14])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-42.40, 23.67], t(2038) = -0.56, p = 0.578; Std. beta = -1.75,
## 95% CI [-4.45, 0.95])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.60, 95% CI [-12.33, 35.54], t(2038) = 0.95, p = 0.342; Std. beta = 0.90,
## 95% CI [-0.52, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-20.53, 25.54], t(2038) = 0.21, p = 0.831; Std. beta = -0.23,
## 95% CI [-1.72, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.40, 95% CI [-30.40, 7.61], t(2038) = -1.18, p = 0.240; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.36, 95% CI [-4.06, 42.78], t(2038) = 1.62, p = 0.105; Std. beta = 0.92,
## 95% CI [-0.56, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.13, 95% CI [1.38, 20.87], t(2038) = 2.24, p = 0.025; Std. beta = 0.40, 95%
## CI [-0.19, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.02, 95% CI [-3.33, 43.37], t(2038) = 1.68, p = 0.093; Std. beta = 0.70,
## 95% CI [-0.75, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-6.82, 8.57], t(2038) = 0.22, p = 0.823; Std. beta = 0.08, 95%
## CI [-0.39, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.99, 95% CI [-5.71, 21.69], t(2038) = 1.14, p = 0.253; Std. beta = 0.37, 95%
## CI [-0.46, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-11.74, 3.87], t(2038) = -0.99, p = 0.323; Std. beta = 0.05,
## 95% CI [-0.44, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.82, 95% CI [-22.93, 5.28], t(2038) = -1.23, p = 0.220; Std. beta = 0.15,
## 95% CI [-0.80, 1.10])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-4.52, 9.88], t(2038) = 0.73, p = 0.466; Std. beta = 0.21, 95%
## CI [-0.24, 0.65])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.61, 95% CI [-14.46, 3.25], t(2038) = -1.24, p = 0.215; Std. beta = -0.07,
## 95% CI [-0.61, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.47, 95% CI [-29.96, 17.02], t(2038) = -0.54, p = 0.589; Std. beta = 0.34,
## 95% CI [-1.22, 1.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-23.01, 16.67], t(2038) = -0.31, p = 0.754; Std. beta = 0.50,
## 95% CI [-0.69, 1.69])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.75, 95% CI [-19.72, 49.22], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.16, 2.89])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.48, 95% CI [3.16, 35.79], t(2038) = 2.34, p = 0.019; Std. beta = 1.46, 95%
## CI [0.46, 2.45])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-13.64, 33.07], t(2038) = 0.82, p = 0.415; Std. beta = 0.60,
## 95% CI [-0.85, 2.06])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.45, 95% CI [-3.12, 32.01], t(2038) = 1.61, p = 0.107; Std. beta = 0.76,
## 95% CI [-0.30, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-24.32, 34.80], t(2038) = 0.35, p = 0.728; Std. beta = 0.64,
## 95% CI [-1.83, 3.11])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.93, 95% CI [-60.90, 5.03], t(2038) = -1.66, p = 0.097; Std. beta = -1.86,
## 95% CI [-4.17, 0.46])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.67, 95% CI [-30.38, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.58, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.67, 95% CI [-28.37, 37.71], t(2038) = 0.28, p = 0.781; Std. beta = 0.27,
## 95% CI [-1.66, 2.21])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-24.31, 22.68], t(2038) = -0.07, p = 0.946; Std. beta = 0.57,
## 95% CI [-1.48, 2.61])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-7.94, 21.58], t(2038) = 0.91, p = 0.365; Std. beta = 0.43, 95%
## CI [-0.50, 1.37])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-11.66, 16.08], t(2038) = 0.31, p = 0.755; Std. beta = 0.27,
## 95% CI [-0.61, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-28.55, 35.63], t(2038) = 0.22, p = 0.829; Std. beta = 0.61,
## 95% CI [-1.29, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.10, 95% CI [-10.44, 10.65], t(2038) = 0.02, p = 0.985; Std. beta = -0.24,
## 95% CI [-0.92, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.96, 95% CI [-27.07, 3.16], t(2038) = -1.55, p = 0.121; Std. beta = -0.51,
## 95% CI [-1.63, 0.61])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-8.49, 17.26], t(2038) = 0.67, p = 0.505; Std. beta = 0.33, 95%
## CI [-0.45, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-13.62, 14.08], t(2038) = 0.03, p = 0.974; Std. beta = -0.45,
## 95% CI [-1.30, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.18, 20.08], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.58, 95% CI [-38.40, 27.23], t(2038) = -0.33, p = 0.739; Std. beta = -0.30,
## 95% CI [-2.22, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-12.52, 17.33], t(2038) = 0.32, p = 0.752; Std. beta = 0.28,
## 95% CI [-0.61, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-6.57, 27.06], t(2038) = 1.20, p = 0.232; Std. beta = 0.32,
## 95% CI [-0.72, 1.37])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.17, 95% CI [-33.79, -0.56], t(2038) = -2.03, p = 0.043; Std. beta = -0.68,
## 95% CI [-1.77, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.42, 95% CI [-12.65, 13.49], t(2038) = 0.06, p = 0.950; Std. beta = 0.07,
## 95% CI [-0.74, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.25, 95% CI [-16.48, 22.99], t(2038) = 0.32, p = 0.746; Std. beta = 1.30,
## 95% CI [0.07, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-27.85, 1.69], t(2038) = -1.74, p = 0.083; Std. beta = -0.46,
## 95% CI [-1.39, 0.46])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.99, 95% CI [-4.39, 28.37], t(2038) = 1.44, p = 0.151; Std. beta = 0.55,
## 95% CI [-0.44, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.36, 95% CI [0.08, 22.63], t(2038) = 1.97, p = 0.048; Std. beta = 0.47, 95%
## CI [-0.22, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.64, 95% CI [-17.44, 48.72], t(2038) = 0.93, p = 0.354; Std. beta = -2.84,
## 95% CI [-4.98, -0.70])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [4.85, 50.97], t(2038) = 2.37, p = 0.018; Std. beta = 1.73, 95%
## CI [0.26, 3.19])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-21.64, 16.76], t(2038) = -0.25, p = 0.803; Std. beta = 0.03,
## 95% CI [-1.27, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.19, 95% CI [-11.52, 9.14], t(2038) = -0.23, p = 0.821; Std. beta = 0.08,
## 95% CI [-0.85, 1.00])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.19, 95% CI [-0.13, 0.52], t(2038) = 1.16, p = 0.247;
## Std. beta = 0.06, 95% CI [-0.04, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.28, 95% CI [-43.23, 14.68], t(2038) = -0.97, p = 0.334;
## Std. beta = -1.33, 95% CI [-4.03, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.67, 95% CI [-7.30, 12.64], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.25, 95% CI [-0.68, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.52, 95% CI [-15.35, 6.31], t(2038) = -0.82, p = 0.413; Std.
## beta = -0.42, 95% CI [-1.43, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-12.78, 11.61], t(2038) = -0.09, p = 0.925;
## Std. beta = -0.05, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-11.98, 6.79], t(2038) = -0.54, p = 0.588; Std.
## beta = -0.24, 95% CI [-1.12, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.06, 95% CI [-6.07, -0.06], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.29, 95% CI [-0.57, -5.30e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.62, 95% CI [-13.95, 2.72], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.52, 95% CI [-1.30, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-2.37, 3.12], t(2038) = 0.27, p = 0.789; Std.
## beta = 0.03, 95% CI [-0.22, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-5.82, 3.47], t(2038) = -0.50, p = 0.620; Std.
## beta = -0.11, 95% CI [-0.54, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.32, 95% CI [0.39, 6.25], t(2038) = 2.22, p = 0.027; Std.
## beta = 0.31, 95% CI [0.04, 0.58])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.96, 95% CI [0.77, 15.14], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.74, 95% CI [0.07, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-1.94, 3.09], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.05, 95% CI [-0.18, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.39, 6.46], t(2038) = 1.74, p = 0.083; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.52, 95% CI [-4.68, 21.72], t(2038) = 1.27, p = 0.206; Std.
## beta = 0.79, 95% CI [-0.44, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.20, 95% CI [1.69, 14.71], t(2038) = 2.47, p = 0.014; Std.
## beta = 0.76, 95% CI [0.16, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-1.72, 9.19], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.35, 95% CI [-0.16, 0.86])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-7.64, 8.42], t(2038) = 0.10, p = 0.924; Std.
## beta = 0.04, 95% CI [-0.71, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-8.98, 6.92], t(2038) = -0.25, p = 0.799; Std.
## beta = -0.10, 95% CI [-0.84, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-33.22, 41.21], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-24.92, 19.70], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-2.18, 8.25], t(2038) = 1.14, p = 0.254; Std.
## beta = 0.28, 95% CI [-0.20, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.29, 95% CI [-13.89, 28.48], t(2038) = 0.67, p = 0.500; Std.
## beta = 0.68, 95% CI [-1.30, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-5.99, 6.77], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.56, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-4.60, 8.02], t(2038) = 0.53, p = 0.595; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.82, 95% CI [-3.95, 13.59], t(2038) = 1.08, p = 0.281; Std.
## beta = 0.45, 95% CI [-0.37, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-8.16, 2.40], t(2038) = -1.07, p = 0.285; Std.
## beta = -0.27, 95% CI [-0.76, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-7.62, 12.14], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.21, 95% CI [-0.71, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-3.82, 5.63], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.08, 95% CI [-0.36, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.51, 95% CI [-11.01, -0.02], t(2038) = -1.97, p = 0.049;
## Std. beta = -0.51, 95% CI [-1.03, -1.60e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.14, 95% CI [-32.68, 10.40], t(2038) = -1.01, p = 0.311;
## Std. beta = -1.04, 95% CI [-3.05, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.35, 95% CI [-8.95, 9.65], t(2038) = 0.07, p = 0.941; Std.
## beta = 0.03, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.63, 95% CI [-2.41, 5.66], t(2038) = 0.79, p = 0.429; Std.
## beta = 0.15, 95% CI [-0.22, 0.53])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.76, 3.20], t(2038) = -0.99, p = 0.321; Std.
## beta = -0.31, 95% CI [-0.91, 0.30])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-3.68, 11.48], t(2038) = 1.01, p = 0.313; Std.
## beta = 0.36, 95% CI [-0.34, 1.07])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-4.33, 5.33], t(2038) = 0.20, p = 0.839; Std.
## beta = 0.05, 95% CI [-0.40, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.13, 95% CI [4.74, 21.53], t(2038) = 3.07, p = 0.002; Std.
## beta = 1.22, 95% CI [0.44, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-1.90, 9.15], t(2038) = 1.29, p = 0.198; Std.
## beta = 0.34, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-7.24, 3.49], t(2038) = -0.68, p = 0.494; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-6.12, 1.37], t(2038) = -1.24, p = 0.214; Std.
## beta = -0.22, 95% CI [-0.57, 0.13])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.69, 95% CI [-61.60, -27.78], t(2038) = -5.18, p < .001;
## Std. beta = -4.17, 95% CI [-5.74, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.78, 9.91], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.10, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.90, 12.90], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.19, 95% CI [-0.83, 1.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.86, 12.34], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.16, 95% CI [-0.83, 1.15])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to cohort
## = CARE-PF, is at 65.11 (95% CI [54.49, 75.73], t(2038) = 12.02, p < .001).
## Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-10.91, -2.43], t(2038) = -3.08, p = 0.002; Std. beta = -0.45,
## 95% CI [-0.57, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.46, 95% CI [-1.31, 0.38], t(2038) = -1.08, p = 0.281; Std. beta = -0.04,
## 95% CI [-0.21, 0.14])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-42.40, 23.67], t(2038) = -0.56, p = 0.578; Std. beta = -1.75,
## 95% CI [-4.45, 0.95])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.60, 95% CI [-12.33, 35.54], t(2038) = 0.95, p = 0.342; Std. beta = 0.90,
## 95% CI [-0.52, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-20.53, 25.54], t(2038) = 0.21, p = 0.831; Std. beta = -0.23,
## 95% CI [-1.72, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.40, 95% CI [-30.40, 7.61], t(2038) = -1.18, p = 0.240; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.36, 95% CI [-4.06, 42.78], t(2038) = 1.62, p = 0.105; Std. beta = 0.92,
## 95% CI [-0.56, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.13, 95% CI [1.38, 20.87], t(2038) = 2.24, p = 0.025; Std. beta = 0.40, 95%
## CI [-0.19, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.02, 95% CI [-3.33, 43.37], t(2038) = 1.68, p = 0.093; Std. beta = 0.70,
## 95% CI [-0.75, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-6.82, 8.57], t(2038) = 0.22, p = 0.823; Std. beta = 0.08, 95%
## CI [-0.39, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.99, 95% CI [-5.71, 21.69], t(2038) = 1.14, p = 0.253; Std. beta = 0.37, 95%
## CI [-0.46, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-11.74, 3.87], t(2038) = -0.99, p = 0.323; Std. beta = 0.05,
## 95% CI [-0.44, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.82, 95% CI [-22.93, 5.28], t(2038) = -1.23, p = 0.220; Std. beta = 0.15,
## 95% CI [-0.80, 1.10])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-4.52, 9.88], t(2038) = 0.73, p = 0.466; Std. beta = 0.21, 95%
## CI [-0.24, 0.65])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.61, 95% CI [-14.46, 3.25], t(2038) = -1.24, p = 0.215; Std. beta = -0.07,
## 95% CI [-0.61, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.47, 95% CI [-29.96, 17.02], t(2038) = -0.54, p = 0.589; Std. beta = 0.34,
## 95% CI [-1.22, 1.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-23.01, 16.67], t(2038) = -0.31, p = 0.754; Std. beta = 0.50,
## 95% CI [-0.69, 1.69])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.75, 95% CI [-19.72, 49.22], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.16, 2.89])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.48, 95% CI [3.16, 35.79], t(2038) = 2.34, p = 0.019; Std. beta = 1.46, 95%
## CI [0.46, 2.45])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-13.64, 33.07], t(2038) = 0.82, p = 0.415; Std. beta = 0.60,
## 95% CI [-0.85, 2.06])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.45, 95% CI [-3.12, 32.01], t(2038) = 1.61, p = 0.107; Std. beta = 0.76,
## 95% CI [-0.30, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-24.32, 34.80], t(2038) = 0.35, p = 0.728; Std. beta = 0.64,
## 95% CI [-1.83, 3.11])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.93, 95% CI [-60.90, 5.03], t(2038) = -1.66, p = 0.097; Std. beta = -1.86,
## 95% CI [-4.17, 0.46])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.67, 95% CI [-30.38, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.58, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.67, 95% CI [-28.37, 37.71], t(2038) = 0.28, p = 0.781; Std. beta = 0.27,
## 95% CI [-1.66, 2.21])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-24.31, 22.68], t(2038) = -0.07, p = 0.946; Std. beta = 0.57,
## 95% CI [-1.48, 2.61])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-7.94, 21.58], t(2038) = 0.91, p = 0.365; Std. beta = 0.43, 95%
## CI [-0.50, 1.37])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-11.66, 16.08], t(2038) = 0.31, p = 0.755; Std. beta = 0.27,
## 95% CI [-0.61, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-28.55, 35.63], t(2038) = 0.22, p = 0.829; Std. beta = 0.61,
## 95% CI [-1.29, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.10, 95% CI [-10.44, 10.65], t(2038) = 0.02, p = 0.985; Std. beta = -0.24,
## 95% CI [-0.92, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.96, 95% CI [-27.07, 3.16], t(2038) = -1.55, p = 0.121; Std. beta = -0.51,
## 95% CI [-1.63, 0.61])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-8.49, 17.26], t(2038) = 0.67, p = 0.505; Std. beta = 0.33, 95%
## CI [-0.45, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-13.62, 14.08], t(2038) = 0.03, p = 0.974; Std. beta = -0.45,
## 95% CI [-1.30, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.18, 20.08], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.58, 95% CI [-38.40, 27.23], t(2038) = -0.33, p = 0.739; Std. beta = -0.30,
## 95% CI [-2.22, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-12.52, 17.33], t(2038) = 0.32, p = 0.752; Std. beta = 0.28,
## 95% CI [-0.61, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-6.57, 27.06], t(2038) = 1.20, p = 0.232; Std. beta = 0.32,
## 95% CI [-0.72, 1.37])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.17, 95% CI [-33.79, -0.56], t(2038) = -2.03, p = 0.043; Std. beta = -0.68,
## 95% CI [-1.77, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.42, 95% CI [-12.65, 13.49], t(2038) = 0.06, p = 0.950; Std. beta = 0.07,
## 95% CI [-0.74, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.25, 95% CI [-16.48, 22.99], t(2038) = 0.32, p = 0.746; Std. beta = 1.30,
## 95% CI [0.07, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-27.85, 1.69], t(2038) = -1.74, p = 0.083; Std. beta = -0.46,
## 95% CI [-1.39, 0.46])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.99, 95% CI [-4.39, 28.37], t(2038) = 1.44, p = 0.151; Std. beta = 0.55,
## 95% CI [-0.44, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.36, 95% CI [0.08, 22.63], t(2038) = 1.97, p = 0.048; Std. beta = 0.47, 95%
## CI [-0.22, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.64, 95% CI [-17.44, 48.72], t(2038) = 0.93, p = 0.354; Std. beta = -2.84,
## 95% CI [-4.98, -0.70])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [4.85, 50.97], t(2038) = 2.37, p = 0.018; Std. beta = 1.73, 95%
## CI [0.26, 3.19])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-21.64, 16.76], t(2038) = -0.25, p = 0.803; Std. beta = 0.03,
## 95% CI [-1.27, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.19, 95% CI [-11.52, 9.14], t(2038) = -0.23, p = 0.821; Std. beta = 0.08,
## 95% CI [-0.85, 1.00])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.19, 95% CI [-0.13, 0.52], t(2038) = 1.16, p = 0.247;
## Std. beta = 0.06, 95% CI [-0.04, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.28, 95% CI [-43.23, 14.68], t(2038) = -0.97, p = 0.334;
## Std. beta = -1.33, 95% CI [-4.03, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.67, 95% CI [-7.30, 12.64], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.25, 95% CI [-0.68, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.52, 95% CI [-15.35, 6.31], t(2038) = -0.82, p = 0.413; Std.
## beta = -0.42, 95% CI [-1.43, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-12.78, 11.61], t(2038) = -0.09, p = 0.925;
## Std. beta = -0.05, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-11.98, 6.79], t(2038) = -0.54, p = 0.588; Std.
## beta = -0.24, 95% CI [-1.12, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.06, 95% CI [-6.07, -0.06], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.29, 95% CI [-0.57, -5.30e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.62, 95% CI [-13.95, 2.72], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.52, 95% CI [-1.30, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-2.37, 3.12], t(2038) = 0.27, p = 0.789; Std.
## beta = 0.03, 95% CI [-0.22, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-5.82, 3.47], t(2038) = -0.50, p = 0.620; Std.
## beta = -0.11, 95% CI [-0.54, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.32, 95% CI [0.39, 6.25], t(2038) = 2.22, p = 0.027; Std.
## beta = 0.31, 95% CI [0.04, 0.58])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.96, 95% CI [0.77, 15.14], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.74, 95% CI [0.07, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-1.94, 3.09], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.05, 95% CI [-0.18, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.39, 6.46], t(2038) = 1.74, p = 0.083; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.52, 95% CI [-4.68, 21.72], t(2038) = 1.27, p = 0.206; Std.
## beta = 0.79, 95% CI [-0.44, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.20, 95% CI [1.69, 14.71], t(2038) = 2.47, p = 0.014; Std.
## beta = 0.76, 95% CI [0.16, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-1.72, 9.19], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.35, 95% CI [-0.16, 0.86])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-7.64, 8.42], t(2038) = 0.10, p = 0.924; Std.
## beta = 0.04, 95% CI [-0.71, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-8.98, 6.92], t(2038) = -0.25, p = 0.799; Std.
## beta = -0.10, 95% CI [-0.84, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-33.22, 41.21], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-24.92, 19.70], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-2.18, 8.25], t(2038) = 1.14, p = 0.254; Std.
## beta = 0.28, 95% CI [-0.20, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.29, 95% CI [-13.89, 28.48], t(2038) = 0.67, p = 0.500; Std.
## beta = 0.68, 95% CI [-1.30, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-5.99, 6.77], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.56, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-4.60, 8.02], t(2038) = 0.53, p = 0.595; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.82, 95% CI [-3.95, 13.59], t(2038) = 1.08, p = 0.281; Std.
## beta = 0.45, 95% CI [-0.37, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-8.16, 2.40], t(2038) = -1.07, p = 0.285; Std.
## beta = -0.27, 95% CI [-0.76, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-7.62, 12.14], t(2038) = 0.45, p = 0.654; Std.
## beta = 0.21, 95% CI [-0.71, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-3.82, 5.63], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.08, 95% CI [-0.36, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.51, 95% CI [-11.01, -0.02], t(2038) = -1.97, p = 0.049;
## Std. beta = -0.51, 95% CI [-1.03, -1.60e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.14, 95% CI [-32.68, 10.40], t(2038) = -1.01, p = 0.311;
## Std. beta = -1.04, 95% CI [-3.05, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.35, 95% CI [-8.95, 9.65], t(2038) = 0.07, p = 0.941; Std.
## beta = 0.03, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.63, 95% CI [-2.41, 5.66], t(2038) = 0.79, p = 0.429; Std.
## beta = 0.15, 95% CI [-0.22, 0.53])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.76, 3.20], t(2038) = -0.99, p = 0.321; Std.
## beta = -0.31, 95% CI [-0.91, 0.30])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-3.68, 11.48], t(2038) = 1.01, p = 0.313; Std.
## beta = 0.36, 95% CI [-0.34, 1.07])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-4.33, 5.33], t(2038) = 0.20, p = 0.839; Std.
## beta = 0.05, 95% CI [-0.40, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.13, 95% CI [4.74, 21.53], t(2038) = 3.07, p = 0.002; Std.
## beta = 1.22, 95% CI [0.44, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-1.90, 9.15], t(2038) = 1.29, p = 0.198; Std.
## beta = 0.34, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-7.24, 3.49], t(2038) = -0.68, p = 0.494; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-6.12, 1.37], t(2038) = -1.24, p = 0.214; Std.
## beta = -0.22, 95% CI [-0.57, 0.13])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.69, 95% CI [-61.60, -27.78], t(2038) = -5.18, p < .001;
## Std. beta = -4.17, 95% CI [-5.74, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.78, 9.91], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.10, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.90, 12.90], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.19, 95% CI [-0.83, 1.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.86, 12.34], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.16, 95% CI [-0.83, 1.15])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*PM_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT * disadv +
## time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14189.9
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2596 -0.4405 -0.0126 0.4512 4.5349
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 231.71 15.222
## time_firstPFT 13.52 3.677 -0.06
## Residual 25.76 5.076
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 31.03422 8.30542 3.737
## time_firstPFT -3.79089 3.29926 -1.149
## PM_5yrPreDx 0.05863 0.43170 0.136
## disadv 4.12477 2.88865 1.428
## dich_RaceNon-White -7.36107 2.83053 -2.601
## sexF 3.56934 1.75564 2.033
## age_dx 0.38904 0.09139 4.257
## smokeHxFormer 3.72264 1.72749 2.155
## smokeHxAlways 18.58571 8.41934 2.208
## smokeHxUnknown -2.35229 3.93053 -0.598
## site02R -11.04579 16.21889 -0.681
## site03R 12.28462 11.85988 1.036
## site04R 3.11364 11.26193 0.276
## site05R -12.43580 9.33600 -1.332
## site06R 10.63031 16.13422 0.659
## site07R 11.76694 4.80217 2.450
## site09R 20.61320 11.47091 1.797
## site101 4.59687 3.86890 1.188
## site102 12.83156 6.84805 1.874
## site103 -0.87620 4.03459 -0.217
## site104 -6.57590 7.00838 -0.938
## site105 4.77070 3.60091 1.325
## site106 -5.31359 4.44395 -1.196
## site107 -1.98399 11.54059 -0.172
## site108 5.48056 10.26247 0.534
## site10R 13.57160 17.15060 0.791
## site11R 17.38440 7.98650 2.177
## site12R 7.45251 11.42484 0.652
## site13R 17.63728 8.69135 2.029
## site14R 6.15253 14.73047 0.418
## site15R -33.92574 16.18482 -2.096
## site16R -8.88917 7.32556 -1.213
## site17R 10.48925 16.35031 0.642
## site18R -3.24446 11.52796 -0.281
## site19R 9.29329 7.28903 1.275
## site20R 2.52361 6.82712 0.370
## site21R 2.67827 15.64998 0.171
## site22R -2.42434 5.25782 -0.461
## site23R -12.98728 8.91678 -1.456
## site24R 4.99652 6.31679 0.791
## site25R 0.79625 6.88093 0.116
## site28R 4.15417 9.42709 0.441
## site29R -6.05980 16.10489 -0.376
## site31R 5.70486 7.43368 0.767
## site32R 9.64769 8.28477 1.165
## site33R -13.98671 8.17474 -1.711
## site34R 0.28907 6.41650 0.045
## site35R -0.18658 9.69822 -0.019
## site36R -11.32652 7.26035 -1.560
## site37R 15.76306 8.12604 1.940
## site38R 12.56819 5.54074 2.268
## site39R 24.34211 16.56861 1.469
## site40R 25.74146 11.29074 2.280
## site41R -2.86689 9.48803 -0.302
## site42R -0.87801 5.13498 -0.171
## time_firstPFT:PM_5yrPreDx 0.16866 0.18078 0.933
## time_firstPFT:disadv -0.18467 1.10238 -0.168
## time_firstPFT:dich_RaceNon-White -0.03908 1.12899 -0.035
## time_firstPFT:sexF -0.14208 0.67178 -0.211
## time_firstPFT:age_dx -0.05067 0.03494 -1.450
## time_firstPFT:smokeHxFormer 0.44934 0.67411 0.667
## time_firstPFT:smokeHxAlways 1.68645 5.32671 0.317
## time_firstPFT:smokeHxUnknown 1.30986 1.69682 0.772
## time_firstPFT:site02R -13.83799 14.81526 -0.934
## time_firstPFT:site03R 3.66980 5.18404 0.708
## time_firstPFT:site04R -4.21744 5.61792 -0.751
## time_firstPFT:site05R -0.28287 6.26692 -0.045
## time_firstPFT:site07R -2.77897 1.59147 -1.746
## time_firstPFT:site09R -5.62663 4.35683 -1.291
## time_firstPFT:site101 0.38927 1.45500 0.268
## time_firstPFT:site102 -1.47985 2.45990 -0.602
## time_firstPFT:site103 3.38004 1.63220 2.071
## time_firstPFT:site104 8.30859 3.79230 2.191
## time_firstPFT:site105 0.50729 1.32687 0.382
## time_firstPFT:site106 3.44286 1.82783 1.884
## time_firstPFT:site107 8.42826 6.78134 1.243
## time_firstPFT:site108 8.15529 3.63816 2.242
## time_firstPFT:site11R 4.41941 2.87672 1.536
## time_firstPFT:site12R 0.60755 4.19916 0.145
## time_firstPFT:site13R -0.73619 4.15199 -0.177
## time_firstPFT:site14R 4.18558 19.01470 0.220
## time_firstPFT:site15R -2.28029 11.43261 -0.199
## time_firstPFT:site16R 2.74419 2.78238 0.986
## time_firstPFT:site18R 7.66097 10.84791 0.706
## time_firstPFT:site19R 0.94254 3.33612 0.283
## time_firstPFT:site20R 2.28716 3.31372 0.690
## time_firstPFT:site21R 4.88598 4.56604 1.070
## time_firstPFT:site22R -2.20354 2.76921 -0.796
## time_firstPFT:site23R 9.83174 24.75180 0.397
## time_firstPFT:site24R 0.83487 2.45689 0.340
## time_firstPFT:site25R -4.98601 2.90320 -1.717
## time_firstPFT:site28R -9.39144 11.11051 -0.845
## time_firstPFT:site29R 0.66921 4.86445 0.138
## time_firstPFT:site31R 1.63796 2.17446 0.753
## time_firstPFT:site32R -2.74524 3.39203 -0.809
## time_firstPFT:site33R 4.28916 3.99307 1.074
## time_firstPFT:site34R 0.58886 2.53637 0.232
## time_firstPFT:site35R 13.74147 4.36221 3.150
## time_firstPFT:site36R 3.82054 2.88787 1.323
## time_firstPFT:site37R -1.28181 2.88840 -0.444
## time_firstPFT:site38R -2.21093 1.95772 -1.129
## time_firstPFT:site39R -45.00883 8.80439 -5.112
## time_firstPFT:site40R 1.95467 4.65211 0.420
## time_firstPFT:site41R 2.60862 5.61691 0.464
## time_firstPFT:site42R 2.49934 5.42480 0.461##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.917
## Unadjusted ICC: 0.692report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## PM_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 31.03 (95% CI [14.75, 47.32], t(2008)
## = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## PM_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to PM_5yrPreDx = 0, is at 31.03 (95% CI
## [14.75, 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 31.03 (95% CI [14.75,
## 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to dich_Race = White, is at 31.03 (95% CI
## [14.75, 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 31.03 (95% CI [14.75,
## 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 31.03 (95% CI [14.75,
## 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 31.03 (95% CI
## [14.75, 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 31.03 (95% CI [14.75,
## 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to cohort = CARE-PF, is at 31.03 (95% CI
## [14.75, 47.32], t(2008) = 3.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.79, 95% CI [-10.26, 2.68], t(2008) = -1.15, p = 0.251; Std. beta =
## -0.49, 95% CI [-0.66, -0.32])
## - The effect of PM 5yrPreDx is statistically non-significant and positive (beta
## = 0.06, 95% CI [-0.79, 0.91], t(2008) = 0.14, p = 0.892; Std. beta = 0.06, 95%
## CI [-0.12, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.12, 95% CI [-1.54, 9.79], t(2008) = 1.43, p = 0.153; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.91, -1.81], t(2008) = -2.60, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.79, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.03, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.59, 95% CI [2.07, 35.10], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.23, 95% CI [0.05, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.35, 95% CI [-10.06, 5.36], t(2008) = -0.60, p = 0.550; Std. beta =
## -0.03, 95% CI [-0.53, 0.47])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.05, 95% CI [-42.85, 20.76], t(2008) = -0.68, p = 0.496; Std. beta =
## -1.82, 95% CI [-4.49, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.28, 95% CI [-10.97, 35.54], t(2008) = 1.04, p = 0.300; Std. beta = 1.03,
## 95% CI [-0.37, 2.43])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.11, 95% CI [-18.97, 25.20], t(2008) = 0.28, p = 0.782; Std. beta = -0.17,
## 95% CI [-1.64, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.44, 95% CI [-30.75, 5.87], t(2008) = -1.33, p = 0.183; Std. beta = -0.75,
## 95% CI [-2.08, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-21.01, 42.27], t(2008) = 0.66, p = 0.510; Std. beta = 0.62,
## 95% CI [-1.23, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.77, 95% CI [2.35, 21.18], t(2008) = 2.45, p = 0.014; Std. beta = 0.46, 95%
## CI [-0.12, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-1.88, 43.11], t(2008) = 1.80, p = 0.072; Std. beta = 0.73,
## 95% CI [-0.69, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.60, 95% CI [-2.99, 12.18], t(2008) = 1.19, p = 0.235; Std. beta = 0.30, 95%
## CI [-0.17, 0.78])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.83, 95% CI [-0.60, 26.26], t(2008) = 1.87, p = 0.061; Std. beta = 0.63,
## 95% CI [-0.20, 1.46])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-8.79, 7.04], t(2008) = -0.22, p = 0.828; Std. beta = 0.23,
## 95% CI [-0.27, 0.74])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.58, 95% CI [-20.32, 7.17], t(2008) = -0.94, p = 0.348; Std. beta = 0.32,
## 95% CI [-0.63, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-2.29, 11.83], t(2008) = 1.32, p = 0.185; Std. beta = 0.32, 95%
## CI [-0.12, 0.76])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-14.03, 3.40], t(2008) = -1.20, p = 0.232; Std. beta = -0.02,
## 95% CI [-0.56, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.98, 95% CI [-24.62, 20.65], t(2008) = -0.17, p = 0.864; Std. beta = 0.60,
## 95% CI [-0.93, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.48, 95% CI [-14.65, 25.61], t(2008) = 0.53, p = 0.593; Std. beta = 1.01,
## 95% CI [-0.22, 2.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.57, 95% CI [-20.06, 47.21], t(2008) = 0.79, p = 0.429; Std. beta = 0.80,
## 95% CI [-1.18, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.38, 95% CI [1.72, 33.05], t(2008) = 2.18, p = 0.030; Std. beta = 1.39, 95%
## CI [0.42, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-14.95, 29.86], t(2008) = 0.65, p = 0.514; Std. beta = 0.49,
## 95% CI [-0.94, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.64, 95% CI [0.59, 34.68], t(2008) = 2.03, p = 0.043; Std. beta = 0.97, 95%
## CI [-0.08, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-22.74, 35.04], t(2008) = 0.42, p = 0.676; Std. beta = 0.71,
## 95% CI [-1.75, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.93, 95% CI [-65.67, -2.18], t(2008) = -2.10, p = 0.036; Std. beta = -2.18,
## 95% CI [-4.46, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-23.26, 5.48], t(2008) = -1.21, p = 0.225; Std. beta = -0.29,
## 95% CI [-1.20, 0.62])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.49, 95% CI [-21.58, 42.55], t(2008) = 0.64, p = 0.521; Std. beta = 0.61,
## 95% CI [-1.26, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-25.85, 19.36], t(2008) = -0.28, p = 0.778; Std. beta = 0.46,
## 95% CI [-1.57, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.29, 95% CI [-5.00, 23.59], t(2008) = 1.27, p = 0.202; Std. beta = 0.62, 95%
## CI [-0.30, 1.55])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-10.87, 15.91], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-0.54, 1.22])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.68, 95% CI [-28.01, 33.37], t(2008) = 0.17, p = 0.864; Std. beta = 0.57,
## 95% CI [-1.27, 2.41])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.42, 95% CI [-12.74, 7.89], t(2008) = -0.46, p = 0.645; Std. beta = -0.33,
## 95% CI [-1.01, 0.35])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-30.47, 4.50], t(2008) = -1.46, p = 0.145; Std. beta = 0.07,
## 95% CI [-3.76, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.00, 95% CI [-7.39, 17.38], t(2008) = 0.79, p = 0.429; Std. beta = 0.36, 95%
## CI [-0.41, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.80, 95% CI [-12.70, 14.29], t(2008) = 0.12, p = 0.908; Std. beta = -0.37,
## 95% CI [-1.22, 0.47])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.33, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.06, 95% CI [-37.64, 25.52], t(2008) = -0.38, p = 0.707; Std. beta = -0.30,
## 95% CI [-2.17, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.70, 95% CI [-8.87, 20.28], t(2008) = 0.77, p = 0.443; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.60, 25.90], t(2008) = 1.16, p = 0.244; Std. beta = 0.33, 95%
## CI [-0.69, 1.36])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.99, 95% CI [-30.02, 2.05], t(2008) = -1.71, p = 0.087; Std. beta = -0.46,
## 95% CI [-1.54, 0.62])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.29, 95% CI [-12.29, 12.87], t(2008) = 0.05, p = 0.964; Std. beta = 0.07,
## 95% CI [-0.72, 0.86])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.19, 95% CI [-19.21, 18.83], t(2008) = -0.02, p = 0.985; Std. beta = 1.15,
## 95% CI [-0.06, 2.36])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.33, 95% CI [-25.57, 2.91], t(2008) = -1.56, p = 0.119; Std. beta = -0.34,
## 95% CI [-1.25, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.17, 31.70], t(2008) = 1.94, p = 0.053; Std. beta = 0.82,
## 95% CI [-0.16, 1.79])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.57, 95% CI [1.70, 23.43], t(2008) = 2.27, p = 0.023; Std. beta = 0.55, 95%
## CI [-0.12, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.34, 95% CI [-8.15, 56.84], t(2008) = 1.47, p = 0.142; Std. beta = -2.37,
## 95% CI [-4.51, -0.23])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.74, 95% CI [3.60, 47.88], t(2008) = 2.28, p = 0.023; Std. beta = 1.67, 95%
## CI [0.23, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-21.47, 15.74], t(2008) = -0.30, p = 0.763; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-10.95, 9.19], t(2008) = -0.17, p = 0.864; Std. beta = 0.16,
## 95% CI [-0.77, 1.08])
## - The effect of time firstPFT × PM 5yrPreDx is statistically non-significant
## and positive (beta = 0.17, 95% CI [-0.19, 0.52], t(2008) = 0.93, p = 0.351;
## Std. beta = 0.05, 95% CI [-0.06, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.35, 1.98], t(2008) = -0.17, p = 0.867; Std.
## beta = -4.94e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.04, 95% CI [-2.25, 2.18], t(2008) =
## -0.03, p = 0.972; Std. beta = -3.65e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-1.46, 1.18], t(2008) = -0.21, p = 0.833; Std.
## beta = -0.01, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.87, 1.77], t(2008) =
## 0.67, p = 0.505; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.69, 95% CI [-8.76, 12.13], t(2008) =
## 0.32, p = 0.752; Std. beta = 0.16, 95% CI [-0.82, 1.13])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.31, 95% CI [-2.02, 4.64], t(2008) =
## 0.77, p = 0.440; Std. beta = 0.12, 95% CI [-0.19, 0.43])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.84, 95% CI [-42.89, 15.22], t(2008) = -0.93, p = 0.350;
## Std. beta = -1.29, 95% CI [-4.01, 1.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-6.50, 13.84], t(2008) = 0.71, p = 0.479; Std.
## beta = 0.34, 95% CI [-0.61, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-15.24, 6.80], t(2008) = -0.75, p = 0.453; Std.
## beta = -0.39, 95% CI [-1.42, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-12.57, 12.01], t(2008) = -0.05, p = 0.964;
## Std. beta = -0.03, 95% CI [-1.17, 1.12])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-5.90, 0.34], t(2008) = -1.75, p = 0.081; Std.
## beta = -0.26, 95% CI [-0.55, 0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.63, 95% CI [-14.17, 2.92], t(2008) = -1.29, p = 0.197; Std.
## beta = -0.53, 95% CI [-1.32, 0.27])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-2.46, 3.24], t(2008) = 0.27, p = 0.789; Std.
## beta = 0.04, 95% CI [-0.23, 0.30])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-6.30, 3.34], t(2008) = -0.60, p = 0.548; Std.
## beta = -0.14, 95% CI [-0.59, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.38, 95% CI [0.18, 6.58], t(2008) = 2.07, p = 0.039; Std.
## beta = 0.32, 95% CI [0.02, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 8.31, 95% CI [0.87, 15.75], t(2008) = 2.19, p = 0.029; Std.
## beta = 0.78, 95% CI [0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.51, 95% CI [-2.09, 3.11], t(2008) = 0.38, p = 0.702; Std.
## beta = 0.05, 95% CI [-0.20, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-0.14, 7.03], t(2008) = 1.88, p = 0.060; Std.
## beta = 0.32, 95% CI [-0.01, 0.66])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.43, 95% CI [-4.87, 21.73], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.79, 95% CI [-0.46, 2.03])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.16, 95% CI [1.02, 15.29], t(2008) = 2.24, p = 0.025; Std.
## beta = 0.76, 95% CI [0.10, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-1.22, 10.06], t(2008) = 1.54, p = 0.125; Std.
## beta = 0.41, 95% CI [-0.11, 0.94])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-7.63, 8.84], t(2008) = 0.14, p = 0.885; Std.
## beta = 0.06, 95% CI [-0.71, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.88, 7.41], t(2008) = -0.18, p = 0.859; Std.
## beta = -0.07, 95% CI [-0.83, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.19, 95% CI [-33.11, 41.48], t(2008) = 0.22, p = 0.826; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-24.70, 20.14], t(2008) = -0.20, p = 0.842;
## Std. beta = -0.21, 95% CI [-2.31, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-2.71, 8.20], t(2008) = 0.99, p = 0.324; Std.
## beta = 0.26, 95% CI [-0.25, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.66, 95% CI [-13.61, 28.94], t(2008) = 0.71, p = 0.480; Std.
## beta = 0.72, 95% CI [-1.27, 2.70])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-5.60, 7.49], t(2008) = 0.28, p = 0.778; Std.
## beta = 0.09, 95% CI [-0.52, 0.70])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-4.21, 8.79], t(2008) = 0.69, p = 0.490; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-4.07, 13.84], t(2008) = 1.07, p = 0.285; Std.
## beta = 0.46, 95% CI [-0.38, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-7.63, 3.23], t(2008) = -0.80, p = 0.426; Std.
## beta = -0.21, 95% CI [-0.71, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.83, 95% CI [-38.71, 58.37], t(2008) = 0.40, p = 0.691; Std.
## beta = 0.92, 95% CI [-3.62, 5.45])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.98, 5.65], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.08, 95% CI [-0.37, 0.53])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-10.68, 0.71], t(2008) = -1.72, p = 0.086; Std.
## beta = -0.47, 95% CI [-1.00, 0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.39, 95% CI [-31.18, 12.40], t(2008) = -0.85, p = 0.398;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-8.87, 10.21], t(2008) = 0.14, p = 0.891; Std.
## beta = 0.06, 95% CI [-0.83, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-2.63, 5.90], t(2008) = 0.75, p = 0.451; Std.
## beta = 0.15, 95% CI [-0.25, 0.55])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-9.40, 3.91], t(2008) = -0.81, p = 0.418; Std.
## beta = -0.26, 95% CI [-0.88, 0.37])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-3.54, 12.12], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-4.39, 5.56], t(2008) = 0.23, p = 0.816; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.74, 95% CI [5.19, 22.30], t(2008) = 3.15, p = 0.002; Std.
## beta = 1.28, 95% CI [0.48, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-1.84, 9.48], t(2008) = 1.32, p = 0.186; Std.
## beta = 0.36, 95% CI [-0.17, 0.89])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.28, 95% CI [-6.95, 4.38], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.12, 95% CI [-0.65, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-6.05, 1.63], t(2008) = -1.13, p = 0.259; Std.
## beta = -0.21, 95% CI [-0.57, 0.15])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.01, 95% CI [-62.28, -27.74], t(2008) = -5.11, p < .001;
## Std. beta = -4.21, 95% CI [-5.82, -2.59])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-7.17, 11.08], t(2008) = 0.42, p = 0.674; Std.
## beta = 0.18, 95% CI [-0.67, 1.04])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.61, 95% CI [-8.41, 13.62], t(2008) = 0.46, p = 0.642; Std.
## beta = 0.24, 95% CI [-0.79, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-8.14, 13.14], t(2008) = 0.46, p = 0.645; Std.
## beta = 0.23, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*SO4_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14375.2
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2934 -0.4398 -0.0203 0.4491 4.6096
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 254.70 15.959
## time_firstPFT 12.67 3.560 -0.08
## Residual 25.71 5.071
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 64.196498 4.198057 15.292
## time_firstPFT -7.158908 1.755557 -4.078
## SO4_5yrPreDx -1.140689 0.962135 -1.186
## site02R -11.689814 17.090715 -0.684
## site03R 10.114558 12.417654 0.815
## site04R 0.715816 11.915251 0.060
## site05R -11.750610 9.695397 -1.212
## site06R 17.708919 12.089551 1.465
## site07R 10.179711 5.199288 1.958
## site09R 18.992027 12.015866 1.581
## site101 0.156119 4.158967 0.038
## site102 7.060252 7.202803 0.980
## site103 -4.928068 4.399973 -1.120
## site104 -9.653360 7.367303 -1.310
## site105 1.408310 4.190950 0.336
## site106 -6.546703 4.793231 -1.366
## site107 -7.948994 12.158658 -0.654
## site108 -3.840505 10.192337 -0.377
## site10R 15.530698 17.719545 0.876
## site11R 18.177258 8.494613 2.140
## site12R 8.667318 12.029466 0.721
## site13R 13.471249 9.069340 1.485
## site14R 4.383763 15.145549 0.289
## site15R -28.718972 16.823151 -1.707
## site16R -16.510642 7.571102 -2.181
## site17R 3.406774 16.930502 0.201
## site18R -2.034921 12.105655 -0.168
## site19R 5.999955 7.690279 0.780
## site20R 1.187416 7.244401 0.164
## site21R 2.078464 16.435625 0.126
## site22R -0.917117 5.588141 -0.164
## site23R -12.883732 7.833283 -1.645
## site24R 3.058740 6.855183 0.446
## site25R -2.116646 7.647711 -0.277
## site28R -0.218042 9.786957 -0.022
## site29R -6.455560 16.791462 -0.384
## site31R 1.784428 7.692700 0.232
## site32R 8.256313 9.004971 0.917
## site33R -17.781241 8.537696 -2.083
## site34R -0.104640 6.738930 -0.016
## site35R 2.522778 10.162853 0.248
## site36R -13.826326 7.596909 -1.820
## site37R 10.924684 8.470331 1.290
## site38R 10.576358 5.882730 1.798
## site39R 14.803533 16.936035 0.874
## site40R 25.126109 12.102012 2.076
## site41R -3.776165 9.984588 -0.378
## site42R -2.140417 5.431731 -0.394
## time_firstPFT:SO4_5yrPreDx 0.662988 0.383258 1.730
## time_firstPFT:site02R -12.577568 14.810081 -0.849
## time_firstPFT:site03R 3.993015 5.180445 0.771
## time_firstPFT:site04R -3.341787 5.581783 -0.599
## time_firstPFT:site05R -0.322257 6.215138 -0.052
## time_firstPFT:site06R -1.425790 4.850805 -0.294
## time_firstPFT:site07R -2.164042 1.678437 -1.289
## time_firstPFT:site09R -4.570109 4.316076 -1.059
## time_firstPFT:site101 1.237531 1.532892 0.807
## time_firstPFT:site102 -0.003697 2.517883 -0.001
## time_firstPFT:site103 4.505181 1.739672 2.590
## time_firstPFT:site104 9.095052 3.742604 2.430
## time_firstPFT:site105 1.714093 1.552581 1.104
## time_firstPFT:site106 3.924479 1.868610 2.100
## time_firstPFT:site107 9.748142 6.790031 1.436
## time_firstPFT:site108 9.258257 3.381617 2.738
## time_firstPFT:site11R 4.719412 2.874689 1.642
## time_firstPFT:site12R 1.438565 4.163437 0.346
## time_firstPFT:site13R -0.087476 4.108631 -0.021
## time_firstPFT:site14R 4.775864 18.979680 0.252
## time_firstPFT:site15R -2.010662 11.376006 -0.177
## time_firstPFT:site16R 3.878253 2.732359 1.419
## time_firstPFT:site18R 8.278086 10.826085 0.765
## time_firstPFT:site19R 1.456992 3.341718 0.436
## time_firstPFT:site20R 2.721546 3.299986 0.825
## time_firstPFT:site21R 5.851609 4.520171 1.295
## time_firstPFT:site22R -2.125927 2.750181 -0.773
## time_firstPFT:site23R 3.064609 5.068356 0.605
## time_firstPFT:site24R 2.057919 2.561815 0.803
## time_firstPFT:site25R -3.910856 3.045696 -1.284
## time_firstPFT:site28R -10.292192 10.997436 -0.936
## time_firstPFT:site29R 1.253203 4.776985 0.262
## time_firstPFT:site31R 2.368366 2.122127 1.116
## time_firstPFT:site32R -1.556559 3.531916 -0.441
## time_firstPFT:site33R 4.555178 3.881128 1.174
## time_firstPFT:site34R 1.283726 2.518963 0.510
## time_firstPFT:site35R 14.037623 4.313294 3.255
## time_firstPFT:site36R 4.144163 2.836951 1.461
## time_firstPFT:site37R -0.996442 2.805558 -0.355
## time_firstPFT:site38R -1.562551 2.008143 -0.778
## time_firstPFT:site39R -43.606436 8.648450 -5.042
## time_firstPFT:site40R 2.519530 4.625430 0.545
## time_firstPFT:site41R 3.136363 5.620525 0.558
## time_firstPFT:site42R 2.454565 5.433597 0.452##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.744report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SO4_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.19. The model's
## intercept, corresponding to time_firstPFT = 0, is at 64.20 (95% CI [55.96,
## 72.43], t(2038) = 15.29, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.16, 95% CI [-10.60, -3.72], t(2038) = -4.08, p < .001; Std. beta = -0.51,
## 95% CI [-0.66, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and negative
## (beta = -1.14, 95% CI [-3.03, 0.75], t(2038) = -1.19, p = 0.236; Std. beta =
## -0.02, 95% CI [-0.23, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.69, 95% CI [-45.21, 21.83], t(2038) = -0.68, p = 0.494; Std. beta =
## -1.74, 95% CI [-4.47, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.11, 95% CI [-14.24, 34.47], t(2038) = 0.81, p = 0.415; Std. beta = 0.93,
## 95% CI [-0.53, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 0.72, 95% CI [-22.65, 24.08], t(2038) = 0.06, p = 0.952; Std. beta = -0.24,
## 95% CI [-1.75, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-30.76, 7.26], t(2038) = -1.21, p = 0.226; Std. beta = -0.72,
## 95% CI [-2.06, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.71, 95% CI [-6.00, 41.42], t(2038) = 1.46, p = 0.143; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 10.18, 95% CI [-0.02, 20.38], t(2038) = 1.96, p = 0.050; Std. beta = 0.41,
## 95% CI [-0.20, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.99, 95% CI [-4.57, 42.56], t(2038) = 1.58, p = 0.114; Std. beta = 0.73,
## 95% CI [-0.74, 2.20])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-8.00, 8.31], t(2038) = 0.04, p = 0.970; Std. beta = 0.11, 95%
## CI [-0.40, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-7.07, 21.19], t(2038) = 0.98, p = 0.327; Std. beta = 0.41, 95%
## CI [-0.45, 1.28])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-13.56, 3.70], t(2038) = -1.12, p = 0.263; Std. beta = 0.09,
## 95% CI [-0.46, 0.63])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-24.10, 4.79], t(2038) = -1.31, p = 0.190; Std. beta = 0.20,
## 95% CI [-0.77, 1.17])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.41, 95% CI [-6.81, 9.63], t(2038) = 0.34, p = 0.737; Std. beta = 0.23, 95%
## CI [-0.28, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.55, 95% CI [-15.95, 2.85], t(2038) = -1.37, p = 0.172; Std. beta = -0.05,
## 95% CI [-0.63, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -7.95, 95% CI [-31.79, 15.90], t(2038) = -0.65, p = 0.513; Std. beta = 0.35,
## 95% CI [-1.23, 1.94])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-23.83, 16.15], t(2038) = -0.38, p = 0.706; Std. beta = 0.55,
## 95% CI [-0.65, 1.76])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 15.53, 95% CI [-19.22, 50.28], t(2038) = 0.88, p = 0.381; Std. beta = 0.91,
## 95% CI [-1.13, 2.95])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.18, 95% CI [1.52, 34.84], t(2038) = 2.14, p = 0.032; Std. beta = 1.46, 95%
## CI [0.44, 2.49])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.67, 95% CI [-14.92, 32.26], t(2038) = 0.72, p = 0.471; Std. beta = 0.63,
## 95% CI [-0.85, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.47, 95% CI [-4.31, 31.26], t(2038) = 1.49, p = 0.138; Std. beta = 0.78,
## 95% CI [-0.30, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-25.32, 34.09], t(2038) = 0.29, p = 0.772; Std. beta = 0.66,
## 95% CI [-1.82, 3.14])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.72, 95% CI [-61.71, 4.27], t(2038) = -1.71, p = 0.088; Std. beta = -1.85,
## 95% CI [-4.17, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.51, 95% CI [-31.36, -1.66], t(2038) = -2.18, p = 0.029; Std. beta = -0.64,
## 95% CI [-1.57, 0.29])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.41, 95% CI [-29.80, 36.61], t(2038) = 0.20, p = 0.841; Std. beta = 0.20,
## 95% CI [-1.75, 2.15])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.03, 95% CI [-25.78, 21.71], t(2038) = -0.17, p = 0.867; Std. beta = 0.58,
## 95% CI [-1.48, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-9.08, 21.08], t(2038) = 0.78, p = 0.435; Std. beta = 0.47, 95%
## CI [-0.49, 1.43])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-13.02, 15.39], t(2038) = 0.16, p = 0.870; Std. beta = 0.30,
## 95% CI [-0.61, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-30.15, 34.31], t(2038) = 0.13, p = 0.899; Std. beta = 0.61,
## 95% CI [-1.30, 2.53])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.92, 95% CI [-11.88, 10.04], t(2038) = -0.16, p = 0.870; Std. beta = -0.23,
## 95% CI [-0.94, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.88, 95% CI [-28.25, 2.48], t(2038) = -1.64, p = 0.100; Std. beta = -0.50,
## 95% CI [-1.63, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-10.39, 16.50], t(2038) = 0.45, p = 0.656; Std. beta = 0.35,
## 95% CI [-0.47, 1.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-17.11, 12.88], t(2038) = -0.28, p = 0.782; Std. beta = -0.45,
## 95% CI [-1.38, 0.48])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -0.22, 95% CI [-19.41, 18.98], t(2038) = -0.02, p = 0.982; Std. beta = -0.88,
## 95% CI [-2.87, 1.11])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-39.39, 26.47], t(2038) = -0.38, p = 0.701; Std. beta = -0.27,
## 95% CI [-2.21, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-13.30, 16.87], t(2038) = 0.23, p = 0.817; Std. beta = 0.30,
## 95% CI [-0.60, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-9.40, 25.92], t(2038) = 0.92, p = 0.359; Std. beta = 0.35, 95%
## CI [-0.75, 1.46])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.78, 95% CI [-34.52, -1.04], t(2038) = -2.08, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.76, 0.44])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.10, 95% CI [-13.32, 13.11], t(2038) = -0.02, p = 0.988; Std. beta = 0.10,
## 95% CI [-0.72, 0.92])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-17.41, 22.45], t(2038) = 0.25, p = 0.804; Std. beta = 1.33,
## 95% CI [0.08, 2.57])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.72, 1.07], t(2038) = -1.82, p = 0.069; Std. beta = -0.46,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 10.92, 95% CI [-5.69, 27.54], t(2038) = 1.29, p = 0.197; Std. beta = 0.56,
## 95% CI [-0.45, 1.56])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-0.96, 22.11], t(2038) = 1.80, p = 0.072; Std. beta = 0.49,
## 95% CI [-0.22, 1.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.80, 95% CI [-18.41, 48.02], t(2038) = 0.87, p = 0.382; Std. beta = -2.80,
## 95% CI [-4.95, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [1.39, 48.86], t(2038) = 2.08, p = 0.038; Std. beta = 1.68, 95%
## CI [0.17, 3.20])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-23.36, 15.80], t(2038) = -0.38, p = 0.705; Std. beta = 0.04,
## 95% CI [-1.28, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-12.79, 8.51], t(2038) = -0.39, p = 0.694; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.66, 95% CI [-0.09, 1.41], t(2038) = 1.73, p = 0.084;
## Std. beta = 0.11, 95% CI [-0.01, 0.23])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-41.62, 16.47], t(2038) = -0.85, p = 0.396;
## Std. beta = -1.17, 95% CI [-3.88, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-6.17, 14.15], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.37, 95% CI [-0.57, 1.32])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-14.29, 7.60], t(2038) = -0.60, p = 0.549; Std.
## beta = -0.31, 95% CI [-1.33, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-12.51, 11.87], t(2038) = -0.05, p = 0.959;
## Std. beta = -0.03, 95% CI [-1.17, 1.11])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-10.94, 8.09], t(2038) = -0.29, p = 0.769; Std.
## beta = -0.13, 95% CI [-1.02, 0.75])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-5.46, 1.13], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.20, 95% CI [-0.51, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.57, 95% CI [-13.03, 3.89], t(2038) = -1.06, p = 0.290; Std.
## beta = -0.43, 95% CI [-1.22, 0.36])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.77, 4.24], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.12, 95% CI [-0.16, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.70e-03, 95% CI [-4.94, 4.93], t(2038) = -1.47e-03, p =
## 0.999; Std. beta = -3.40e-04, 95% CI [-0.46, 0.46])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.92], t(2038) = 2.59, p = 0.010; Std.
## beta = 0.42, 95% CI [0.10, 0.74])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.10, 95% CI [1.76, 16.43], t(2038) = 2.43, p = 0.015; Std.
## beta = 0.85, 95% CI [0.16, 1.53])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.33, 4.76], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.16, 95% CI [-0.12, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 3.92, 95% CI [0.26, 7.59], t(2038) = 2.10, p = 0.036; Std.
## beta = 0.37, 95% CI [0.02, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.75, 95% CI [-3.57, 23.06], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.91, 95% CI [-0.33, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 9.26, 95% CI [2.63, 15.89], t(2038) = 2.74, p = 0.006; Std.
## beta = 0.86, 95% CI [0.24, 1.48])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-0.92, 10.36], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.44, 95% CI [-0.09, 0.97])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.73, 9.60], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.13, 95% CI [-0.63, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-8.15, 7.97], t(2038) = -0.02, p = 0.983; Std.
## beta = -8.15e-03, 95% CI [-0.76, 0.74])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-32.45, 42.00], t(2038) = 0.25, p = 0.801; Std.
## beta = 0.45, 95% CI [-3.03, 3.92])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-24.32, 20.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.19, 95% CI [-2.27, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-1.48, 9.24], t(2038) = 1.42, p = 0.156; Std.
## beta = 0.36, 95% CI [-0.14, 0.86])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.28, 95% CI [-12.95, 29.51], t(2038) = 0.76, p = 0.445; Std.
## beta = 0.77, 95% CI [-1.21, 2.75])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-5.10, 8.01], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.14, 95% CI [-0.48, 0.75])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.75, 9.19], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.25, 95% CI [-0.35, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-3.01, 14.72], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.55, 95% CI [-0.28, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-7.52, 3.27], t(2038) = -0.77, p = 0.440; Std.
## beta = -0.20, 95% CI [-0.70, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-6.88, 13.00], t(2038) = 0.60, p = 0.545; Std.
## beta = 0.29, 95% CI [-0.64, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-2.97, 7.08], t(2038) = 0.80, p = 0.422; Std.
## beta = 0.19, 95% CI [-0.28, 0.66])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.91, 95% CI [-9.88, 2.06], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.36, 95% CI [-0.92, 0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-31.86, 11.28], t(2038) = -0.94, p = 0.349;
## Std. beta = -0.96, 95% CI [-2.97, 1.05])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.12, 10.62], t(2038) = 0.26, p = 0.793; Std.
## beta = 0.12, 95% CI [-0.76, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-1.79, 6.53], t(2038) = 1.12, p = 0.265; Std.
## beta = 0.22, 95% CI [-0.17, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-8.48, 5.37], t(2038) = -0.44, p = 0.659; Std.
## beta = -0.15, 95% CI [-0.79, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-3.06, 12.17], t(2038) = 1.17, p = 0.241; Std.
## beta = 0.42, 95% CI [-0.28, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.66, 6.22], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.12, 95% CI [-0.34, 0.58])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.04, 95% CI [5.58, 22.50], t(2038) = 3.25, p = 0.001; Std.
## beta = 1.31, 95% CI [0.52, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.42, 9.71], t(2038) = 1.46, p = 0.144; Std.
## beta = 0.39, 95% CI [-0.13, 0.91])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.50, 4.51], t(2038) = -0.36, p = 0.723; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-5.50, 2.38], t(2038) = -0.78, p = 0.437; Std.
## beta = -0.15, 95% CI [-0.51, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -43.61, 95% CI [-60.57, -26.65], t(2038) = -5.04, p < .001;
## Std. beta = -4.07, 95% CI [-5.65, -2.48])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-6.55, 11.59], t(2038) = 0.54, p = 0.586; Std.
## beta = 0.23, 95% CI [-0.61, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-7.89, 14.16], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.29, 95% CI [-0.74, 1.32])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-8.20, 13.11], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.23, 95% CI [-0.76, 1.22])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SO4_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.19. The model's intercept,
## corresponding to SO4_5yrPreDx = 0, is at 64.20 (95% CI [55.96, 72.43], t(2038)
## = 15.29, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.16, 95% CI [-10.60, -3.72], t(2038) = -4.08, p < .001; Std. beta = -0.51,
## 95% CI [-0.66, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and negative
## (beta = -1.14, 95% CI [-3.03, 0.75], t(2038) = -1.19, p = 0.236; Std. beta =
## -0.02, 95% CI [-0.23, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.69, 95% CI [-45.21, 21.83], t(2038) = -0.68, p = 0.494; Std. beta =
## -1.74, 95% CI [-4.47, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.11, 95% CI [-14.24, 34.47], t(2038) = 0.81, p = 0.415; Std. beta = 0.93,
## 95% CI [-0.53, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 0.72, 95% CI [-22.65, 24.08], t(2038) = 0.06, p = 0.952; Std. beta = -0.24,
## 95% CI [-1.75, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-30.76, 7.26], t(2038) = -1.21, p = 0.226; Std. beta = -0.72,
## 95% CI [-2.06, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.71, 95% CI [-6.00, 41.42], t(2038) = 1.46, p = 0.143; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 10.18, 95% CI [-0.02, 20.38], t(2038) = 1.96, p = 0.050; Std. beta = 0.41,
## 95% CI [-0.20, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.99, 95% CI [-4.57, 42.56], t(2038) = 1.58, p = 0.114; Std. beta = 0.73,
## 95% CI [-0.74, 2.20])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-8.00, 8.31], t(2038) = 0.04, p = 0.970; Std. beta = 0.11, 95%
## CI [-0.40, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-7.07, 21.19], t(2038) = 0.98, p = 0.327; Std. beta = 0.41, 95%
## CI [-0.45, 1.28])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-13.56, 3.70], t(2038) = -1.12, p = 0.263; Std. beta = 0.09,
## 95% CI [-0.46, 0.63])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-24.10, 4.79], t(2038) = -1.31, p = 0.190; Std. beta = 0.20,
## 95% CI [-0.77, 1.17])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.41, 95% CI [-6.81, 9.63], t(2038) = 0.34, p = 0.737; Std. beta = 0.23, 95%
## CI [-0.28, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.55, 95% CI [-15.95, 2.85], t(2038) = -1.37, p = 0.172; Std. beta = -0.05,
## 95% CI [-0.63, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -7.95, 95% CI [-31.79, 15.90], t(2038) = -0.65, p = 0.513; Std. beta = 0.35,
## 95% CI [-1.23, 1.94])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-23.83, 16.15], t(2038) = -0.38, p = 0.706; Std. beta = 0.55,
## 95% CI [-0.65, 1.76])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 15.53, 95% CI [-19.22, 50.28], t(2038) = 0.88, p = 0.381; Std. beta = 0.91,
## 95% CI [-1.13, 2.95])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.18, 95% CI [1.52, 34.84], t(2038) = 2.14, p = 0.032; Std. beta = 1.46, 95%
## CI [0.44, 2.49])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.67, 95% CI [-14.92, 32.26], t(2038) = 0.72, p = 0.471; Std. beta = 0.63,
## 95% CI [-0.85, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.47, 95% CI [-4.31, 31.26], t(2038) = 1.49, p = 0.138; Std. beta = 0.78,
## 95% CI [-0.30, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-25.32, 34.09], t(2038) = 0.29, p = 0.772; Std. beta = 0.66,
## 95% CI [-1.82, 3.14])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.72, 95% CI [-61.71, 4.27], t(2038) = -1.71, p = 0.088; Std. beta = -1.85,
## 95% CI [-4.17, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.51, 95% CI [-31.36, -1.66], t(2038) = -2.18, p = 0.029; Std. beta = -0.64,
## 95% CI [-1.57, 0.29])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.41, 95% CI [-29.80, 36.61], t(2038) = 0.20, p = 0.841; Std. beta = 0.20,
## 95% CI [-1.75, 2.15])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.03, 95% CI [-25.78, 21.71], t(2038) = -0.17, p = 0.867; Std. beta = 0.58,
## 95% CI [-1.48, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-9.08, 21.08], t(2038) = 0.78, p = 0.435; Std. beta = 0.47, 95%
## CI [-0.49, 1.43])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-13.02, 15.39], t(2038) = 0.16, p = 0.870; Std. beta = 0.30,
## 95% CI [-0.61, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-30.15, 34.31], t(2038) = 0.13, p = 0.899; Std. beta = 0.61,
## 95% CI [-1.30, 2.53])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.92, 95% CI [-11.88, 10.04], t(2038) = -0.16, p = 0.870; Std. beta = -0.23,
## 95% CI [-0.94, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.88, 95% CI [-28.25, 2.48], t(2038) = -1.64, p = 0.100; Std. beta = -0.50,
## 95% CI [-1.63, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-10.39, 16.50], t(2038) = 0.45, p = 0.656; Std. beta = 0.35,
## 95% CI [-0.47, 1.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-17.11, 12.88], t(2038) = -0.28, p = 0.782; Std. beta = -0.45,
## 95% CI [-1.38, 0.48])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -0.22, 95% CI [-19.41, 18.98], t(2038) = -0.02, p = 0.982; Std. beta = -0.88,
## 95% CI [-2.87, 1.11])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-39.39, 26.47], t(2038) = -0.38, p = 0.701; Std. beta = -0.27,
## 95% CI [-2.21, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-13.30, 16.87], t(2038) = 0.23, p = 0.817; Std. beta = 0.30,
## 95% CI [-0.60, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-9.40, 25.92], t(2038) = 0.92, p = 0.359; Std. beta = 0.35, 95%
## CI [-0.75, 1.46])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.78, 95% CI [-34.52, -1.04], t(2038) = -2.08, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.76, 0.44])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.10, 95% CI [-13.32, 13.11], t(2038) = -0.02, p = 0.988; Std. beta = 0.10,
## 95% CI [-0.72, 0.92])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-17.41, 22.45], t(2038) = 0.25, p = 0.804; Std. beta = 1.33,
## 95% CI [0.08, 2.57])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.72, 1.07], t(2038) = -1.82, p = 0.069; Std. beta = -0.46,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 10.92, 95% CI [-5.69, 27.54], t(2038) = 1.29, p = 0.197; Std. beta = 0.56,
## 95% CI [-0.45, 1.56])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-0.96, 22.11], t(2038) = 1.80, p = 0.072; Std. beta = 0.49,
## 95% CI [-0.22, 1.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.80, 95% CI [-18.41, 48.02], t(2038) = 0.87, p = 0.382; Std. beta = -2.80,
## 95% CI [-4.95, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [1.39, 48.86], t(2038) = 2.08, p = 0.038; Std. beta = 1.68, 95%
## CI [0.17, 3.20])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-23.36, 15.80], t(2038) = -0.38, p = 0.705; Std. beta = 0.04,
## 95% CI [-1.28, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-12.79, 8.51], t(2038) = -0.39, p = 0.694; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.66, 95% CI [-0.09, 1.41], t(2038) = 1.73, p = 0.084;
## Std. beta = 0.11, 95% CI [-0.01, 0.23])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-41.62, 16.47], t(2038) = -0.85, p = 0.396;
## Std. beta = -1.17, 95% CI [-3.88, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-6.17, 14.15], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.37, 95% CI [-0.57, 1.32])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-14.29, 7.60], t(2038) = -0.60, p = 0.549; Std.
## beta = -0.31, 95% CI [-1.33, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-12.51, 11.87], t(2038) = -0.05, p = 0.959;
## Std. beta = -0.03, 95% CI [-1.17, 1.11])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-10.94, 8.09], t(2038) = -0.29, p = 0.769; Std.
## beta = -0.13, 95% CI [-1.02, 0.75])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-5.46, 1.13], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.20, 95% CI [-0.51, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.57, 95% CI [-13.03, 3.89], t(2038) = -1.06, p = 0.290; Std.
## beta = -0.43, 95% CI [-1.22, 0.36])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.77, 4.24], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.12, 95% CI [-0.16, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.70e-03, 95% CI [-4.94, 4.93], t(2038) = -1.47e-03, p =
## 0.999; Std. beta = -3.40e-04, 95% CI [-0.46, 0.46])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.92], t(2038) = 2.59, p = 0.010; Std.
## beta = 0.42, 95% CI [0.10, 0.74])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.10, 95% CI [1.76, 16.43], t(2038) = 2.43, p = 0.015; Std.
## beta = 0.85, 95% CI [0.16, 1.53])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.33, 4.76], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.16, 95% CI [-0.12, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 3.92, 95% CI [0.26, 7.59], t(2038) = 2.10, p = 0.036; Std.
## beta = 0.37, 95% CI [0.02, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.75, 95% CI [-3.57, 23.06], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.91, 95% CI [-0.33, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 9.26, 95% CI [2.63, 15.89], t(2038) = 2.74, p = 0.006; Std.
## beta = 0.86, 95% CI [0.24, 1.48])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-0.92, 10.36], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.44, 95% CI [-0.09, 0.97])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.73, 9.60], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.13, 95% CI [-0.63, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-8.15, 7.97], t(2038) = -0.02, p = 0.983; Std.
## beta = -8.15e-03, 95% CI [-0.76, 0.74])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-32.45, 42.00], t(2038) = 0.25, p = 0.801; Std.
## beta = 0.45, 95% CI [-3.03, 3.92])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-24.32, 20.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.19, 95% CI [-2.27, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-1.48, 9.24], t(2038) = 1.42, p = 0.156; Std.
## beta = 0.36, 95% CI [-0.14, 0.86])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.28, 95% CI [-12.95, 29.51], t(2038) = 0.76, p = 0.445; Std.
## beta = 0.77, 95% CI [-1.21, 2.75])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-5.10, 8.01], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.14, 95% CI [-0.48, 0.75])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.75, 9.19], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.25, 95% CI [-0.35, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-3.01, 14.72], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.55, 95% CI [-0.28, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-7.52, 3.27], t(2038) = -0.77, p = 0.440; Std.
## beta = -0.20, 95% CI [-0.70, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-6.88, 13.00], t(2038) = 0.60, p = 0.545; Std.
## beta = 0.29, 95% CI [-0.64, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-2.97, 7.08], t(2038) = 0.80, p = 0.422; Std.
## beta = 0.19, 95% CI [-0.28, 0.66])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.91, 95% CI [-9.88, 2.06], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.36, 95% CI [-0.92, 0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-31.86, 11.28], t(2038) = -0.94, p = 0.349;
## Std. beta = -0.96, 95% CI [-2.97, 1.05])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.12, 10.62], t(2038) = 0.26, p = 0.793; Std.
## beta = 0.12, 95% CI [-0.76, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-1.79, 6.53], t(2038) = 1.12, p = 0.265; Std.
## beta = 0.22, 95% CI [-0.17, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-8.48, 5.37], t(2038) = -0.44, p = 0.659; Std.
## beta = -0.15, 95% CI [-0.79, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-3.06, 12.17], t(2038) = 1.17, p = 0.241; Std.
## beta = 0.42, 95% CI [-0.28, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.66, 6.22], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.12, 95% CI [-0.34, 0.58])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.04, 95% CI [5.58, 22.50], t(2038) = 3.25, p = 0.001; Std.
## beta = 1.31, 95% CI [0.52, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.42, 9.71], t(2038) = 1.46, p = 0.144; Std.
## beta = 0.39, 95% CI [-0.13, 0.91])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.50, 4.51], t(2038) = -0.36, p = 0.723; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-5.50, 2.38], t(2038) = -0.78, p = 0.437; Std.
## beta = -0.15, 95% CI [-0.51, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -43.61, 95% CI [-60.57, -26.65], t(2038) = -5.04, p < .001;
## Std. beta = -4.07, 95% CI [-5.65, -2.48])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-6.55, 11.59], t(2038) = 0.54, p = 0.586; Std.
## beta = 0.23, 95% CI [-0.61, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-7.89, 14.16], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.29, 95% CI [-0.74, 1.32])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-8.20, 13.11], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.23, 95% CI [-0.76, 1.22])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.19. The model's intercept, corresponding to site =
## Simmons, is at 64.20 (95% CI [55.96, 72.43], t(2038) = 15.29, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.16, 95% CI [-10.60, -3.72], t(2038) = -4.08, p < .001; Std. beta = -0.51,
## 95% CI [-0.66, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and negative
## (beta = -1.14, 95% CI [-3.03, 0.75], t(2038) = -1.19, p = 0.236; Std. beta =
## -0.02, 95% CI [-0.23, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.69, 95% CI [-45.21, 21.83], t(2038) = -0.68, p = 0.494; Std. beta =
## -1.74, 95% CI [-4.47, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.11, 95% CI [-14.24, 34.47], t(2038) = 0.81, p = 0.415; Std. beta = 0.93,
## 95% CI [-0.53, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 0.72, 95% CI [-22.65, 24.08], t(2038) = 0.06, p = 0.952; Std. beta = -0.24,
## 95% CI [-1.75, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-30.76, 7.26], t(2038) = -1.21, p = 0.226; Std. beta = -0.72,
## 95% CI [-2.06, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.71, 95% CI [-6.00, 41.42], t(2038) = 1.46, p = 0.143; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 10.18, 95% CI [-0.02, 20.38], t(2038) = 1.96, p = 0.050; Std. beta = 0.41,
## 95% CI [-0.20, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.99, 95% CI [-4.57, 42.56], t(2038) = 1.58, p = 0.114; Std. beta = 0.73,
## 95% CI [-0.74, 2.20])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-8.00, 8.31], t(2038) = 0.04, p = 0.970; Std. beta = 0.11, 95%
## CI [-0.40, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-7.07, 21.19], t(2038) = 0.98, p = 0.327; Std. beta = 0.41, 95%
## CI [-0.45, 1.28])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-13.56, 3.70], t(2038) = -1.12, p = 0.263; Std. beta = 0.09,
## 95% CI [-0.46, 0.63])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-24.10, 4.79], t(2038) = -1.31, p = 0.190; Std. beta = 0.20,
## 95% CI [-0.77, 1.17])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.41, 95% CI [-6.81, 9.63], t(2038) = 0.34, p = 0.737; Std. beta = 0.23, 95%
## CI [-0.28, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.55, 95% CI [-15.95, 2.85], t(2038) = -1.37, p = 0.172; Std. beta = -0.05,
## 95% CI [-0.63, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -7.95, 95% CI [-31.79, 15.90], t(2038) = -0.65, p = 0.513; Std. beta = 0.35,
## 95% CI [-1.23, 1.94])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-23.83, 16.15], t(2038) = -0.38, p = 0.706; Std. beta = 0.55,
## 95% CI [-0.65, 1.76])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 15.53, 95% CI [-19.22, 50.28], t(2038) = 0.88, p = 0.381; Std. beta = 0.91,
## 95% CI [-1.13, 2.95])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.18, 95% CI [1.52, 34.84], t(2038) = 2.14, p = 0.032; Std. beta = 1.46, 95%
## CI [0.44, 2.49])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.67, 95% CI [-14.92, 32.26], t(2038) = 0.72, p = 0.471; Std. beta = 0.63,
## 95% CI [-0.85, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.47, 95% CI [-4.31, 31.26], t(2038) = 1.49, p = 0.138; Std. beta = 0.78,
## 95% CI [-0.30, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-25.32, 34.09], t(2038) = 0.29, p = 0.772; Std. beta = 0.66,
## 95% CI [-1.82, 3.14])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.72, 95% CI [-61.71, 4.27], t(2038) = -1.71, p = 0.088; Std. beta = -1.85,
## 95% CI [-4.17, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.51, 95% CI [-31.36, -1.66], t(2038) = -2.18, p = 0.029; Std. beta = -0.64,
## 95% CI [-1.57, 0.29])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.41, 95% CI [-29.80, 36.61], t(2038) = 0.20, p = 0.841; Std. beta = 0.20,
## 95% CI [-1.75, 2.15])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.03, 95% CI [-25.78, 21.71], t(2038) = -0.17, p = 0.867; Std. beta = 0.58,
## 95% CI [-1.48, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-9.08, 21.08], t(2038) = 0.78, p = 0.435; Std. beta = 0.47, 95%
## CI [-0.49, 1.43])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-13.02, 15.39], t(2038) = 0.16, p = 0.870; Std. beta = 0.30,
## 95% CI [-0.61, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-30.15, 34.31], t(2038) = 0.13, p = 0.899; Std. beta = 0.61,
## 95% CI [-1.30, 2.53])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.92, 95% CI [-11.88, 10.04], t(2038) = -0.16, p = 0.870; Std. beta = -0.23,
## 95% CI [-0.94, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.88, 95% CI [-28.25, 2.48], t(2038) = -1.64, p = 0.100; Std. beta = -0.50,
## 95% CI [-1.63, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-10.39, 16.50], t(2038) = 0.45, p = 0.656; Std. beta = 0.35,
## 95% CI [-0.47, 1.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-17.11, 12.88], t(2038) = -0.28, p = 0.782; Std. beta = -0.45,
## 95% CI [-1.38, 0.48])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -0.22, 95% CI [-19.41, 18.98], t(2038) = -0.02, p = 0.982; Std. beta = -0.88,
## 95% CI [-2.87, 1.11])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-39.39, 26.47], t(2038) = -0.38, p = 0.701; Std. beta = -0.27,
## 95% CI [-2.21, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-13.30, 16.87], t(2038) = 0.23, p = 0.817; Std. beta = 0.30,
## 95% CI [-0.60, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-9.40, 25.92], t(2038) = 0.92, p = 0.359; Std. beta = 0.35, 95%
## CI [-0.75, 1.46])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.78, 95% CI [-34.52, -1.04], t(2038) = -2.08, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.76, 0.44])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.10, 95% CI [-13.32, 13.11], t(2038) = -0.02, p = 0.988; Std. beta = 0.10,
## 95% CI [-0.72, 0.92])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-17.41, 22.45], t(2038) = 0.25, p = 0.804; Std. beta = 1.33,
## 95% CI [0.08, 2.57])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.72, 1.07], t(2038) = -1.82, p = 0.069; Std. beta = -0.46,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 10.92, 95% CI [-5.69, 27.54], t(2038) = 1.29, p = 0.197; Std. beta = 0.56,
## 95% CI [-0.45, 1.56])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-0.96, 22.11], t(2038) = 1.80, p = 0.072; Std. beta = 0.49,
## 95% CI [-0.22, 1.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.80, 95% CI [-18.41, 48.02], t(2038) = 0.87, p = 0.382; Std. beta = -2.80,
## 95% CI [-4.95, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [1.39, 48.86], t(2038) = 2.08, p = 0.038; Std. beta = 1.68, 95%
## CI [0.17, 3.20])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-23.36, 15.80], t(2038) = -0.38, p = 0.705; Std. beta = 0.04,
## 95% CI [-1.28, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-12.79, 8.51], t(2038) = -0.39, p = 0.694; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.66, 95% CI [-0.09, 1.41], t(2038) = 1.73, p = 0.084;
## Std. beta = 0.11, 95% CI [-0.01, 0.23])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-41.62, 16.47], t(2038) = -0.85, p = 0.396;
## Std. beta = -1.17, 95% CI [-3.88, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-6.17, 14.15], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.37, 95% CI [-0.57, 1.32])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-14.29, 7.60], t(2038) = -0.60, p = 0.549; Std.
## beta = -0.31, 95% CI [-1.33, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-12.51, 11.87], t(2038) = -0.05, p = 0.959;
## Std. beta = -0.03, 95% CI [-1.17, 1.11])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-10.94, 8.09], t(2038) = -0.29, p = 0.769; Std.
## beta = -0.13, 95% CI [-1.02, 0.75])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-5.46, 1.13], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.20, 95% CI [-0.51, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.57, 95% CI [-13.03, 3.89], t(2038) = -1.06, p = 0.290; Std.
## beta = -0.43, 95% CI [-1.22, 0.36])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.77, 4.24], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.12, 95% CI [-0.16, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.70e-03, 95% CI [-4.94, 4.93], t(2038) = -1.47e-03, p =
## 0.999; Std. beta = -3.40e-04, 95% CI [-0.46, 0.46])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.92], t(2038) = 2.59, p = 0.010; Std.
## beta = 0.42, 95% CI [0.10, 0.74])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.10, 95% CI [1.76, 16.43], t(2038) = 2.43, p = 0.015; Std.
## beta = 0.85, 95% CI [0.16, 1.53])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.33, 4.76], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.16, 95% CI [-0.12, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 3.92, 95% CI [0.26, 7.59], t(2038) = 2.10, p = 0.036; Std.
## beta = 0.37, 95% CI [0.02, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.75, 95% CI [-3.57, 23.06], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.91, 95% CI [-0.33, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 9.26, 95% CI [2.63, 15.89], t(2038) = 2.74, p = 0.006; Std.
## beta = 0.86, 95% CI [0.24, 1.48])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-0.92, 10.36], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.44, 95% CI [-0.09, 0.97])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.73, 9.60], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.13, 95% CI [-0.63, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-8.15, 7.97], t(2038) = -0.02, p = 0.983; Std.
## beta = -8.15e-03, 95% CI [-0.76, 0.74])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-32.45, 42.00], t(2038) = 0.25, p = 0.801; Std.
## beta = 0.45, 95% CI [-3.03, 3.92])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-24.32, 20.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.19, 95% CI [-2.27, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-1.48, 9.24], t(2038) = 1.42, p = 0.156; Std.
## beta = 0.36, 95% CI [-0.14, 0.86])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.28, 95% CI [-12.95, 29.51], t(2038) = 0.76, p = 0.445; Std.
## beta = 0.77, 95% CI [-1.21, 2.75])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-5.10, 8.01], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.14, 95% CI [-0.48, 0.75])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.75, 9.19], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.25, 95% CI [-0.35, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-3.01, 14.72], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.55, 95% CI [-0.28, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-7.52, 3.27], t(2038) = -0.77, p = 0.440; Std.
## beta = -0.20, 95% CI [-0.70, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-6.88, 13.00], t(2038) = 0.60, p = 0.545; Std.
## beta = 0.29, 95% CI [-0.64, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-2.97, 7.08], t(2038) = 0.80, p = 0.422; Std.
## beta = 0.19, 95% CI [-0.28, 0.66])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.91, 95% CI [-9.88, 2.06], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.36, 95% CI [-0.92, 0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-31.86, 11.28], t(2038) = -0.94, p = 0.349;
## Std. beta = -0.96, 95% CI [-2.97, 1.05])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.12, 10.62], t(2038) = 0.26, p = 0.793; Std.
## beta = 0.12, 95% CI [-0.76, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-1.79, 6.53], t(2038) = 1.12, p = 0.265; Std.
## beta = 0.22, 95% CI [-0.17, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-8.48, 5.37], t(2038) = -0.44, p = 0.659; Std.
## beta = -0.15, 95% CI [-0.79, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-3.06, 12.17], t(2038) = 1.17, p = 0.241; Std.
## beta = 0.42, 95% CI [-0.28, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.66, 6.22], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.12, 95% CI [-0.34, 0.58])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.04, 95% CI [5.58, 22.50], t(2038) = 3.25, p = 0.001; Std.
## beta = 1.31, 95% CI [0.52, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.42, 9.71], t(2038) = 1.46, p = 0.144; Std.
## beta = 0.39, 95% CI [-0.13, 0.91])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.50, 4.51], t(2038) = -0.36, p = 0.723; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-5.50, 2.38], t(2038) = -0.78, p = 0.437; Std.
## beta = -0.15, 95% CI [-0.51, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -43.61, 95% CI [-60.57, -26.65], t(2038) = -5.04, p < .001;
## Std. beta = -4.07, 95% CI [-5.65, -2.48])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-6.55, 11.59], t(2038) = 0.54, p = 0.586; Std.
## beta = 0.23, 95% CI [-0.61, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-7.89, 14.16], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.29, 95% CI [-0.74, 1.32])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-8.20, 13.11], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.23, 95% CI [-0.76, 1.22])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.19. The model's intercept,
## corresponding to cohort = CARE-PF, is at 64.20 (95% CI [55.96, 72.43], t(2038)
## = 15.29, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.16, 95% CI [-10.60, -3.72], t(2038) = -4.08, p < .001; Std. beta = -0.51,
## 95% CI [-0.66, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and negative
## (beta = -1.14, 95% CI [-3.03, 0.75], t(2038) = -1.19, p = 0.236; Std. beta =
## -0.02, 95% CI [-0.23, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.69, 95% CI [-45.21, 21.83], t(2038) = -0.68, p = 0.494; Std. beta =
## -1.74, 95% CI [-4.47, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.11, 95% CI [-14.24, 34.47], t(2038) = 0.81, p = 0.415; Std. beta = 0.93,
## 95% CI [-0.53, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 0.72, 95% CI [-22.65, 24.08], t(2038) = 0.06, p = 0.952; Std. beta = -0.24,
## 95% CI [-1.75, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-30.76, 7.26], t(2038) = -1.21, p = 0.226; Std. beta = -0.72,
## 95% CI [-2.06, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.71, 95% CI [-6.00, 41.42], t(2038) = 1.46, p = 0.143; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 10.18, 95% CI [-0.02, 20.38], t(2038) = 1.96, p = 0.050; Std. beta = 0.41,
## 95% CI [-0.20, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.99, 95% CI [-4.57, 42.56], t(2038) = 1.58, p = 0.114; Std. beta = 0.73,
## 95% CI [-0.74, 2.20])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-8.00, 8.31], t(2038) = 0.04, p = 0.970; Std. beta = 0.11, 95%
## CI [-0.40, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-7.07, 21.19], t(2038) = 0.98, p = 0.327; Std. beta = 0.41, 95%
## CI [-0.45, 1.28])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-13.56, 3.70], t(2038) = -1.12, p = 0.263; Std. beta = 0.09,
## 95% CI [-0.46, 0.63])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-24.10, 4.79], t(2038) = -1.31, p = 0.190; Std. beta = 0.20,
## 95% CI [-0.77, 1.17])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.41, 95% CI [-6.81, 9.63], t(2038) = 0.34, p = 0.737; Std. beta = 0.23, 95%
## CI [-0.28, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.55, 95% CI [-15.95, 2.85], t(2038) = -1.37, p = 0.172; Std. beta = -0.05,
## 95% CI [-0.63, 0.52])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -7.95, 95% CI [-31.79, 15.90], t(2038) = -0.65, p = 0.513; Std. beta = 0.35,
## 95% CI [-1.23, 1.94])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-23.83, 16.15], t(2038) = -0.38, p = 0.706; Std. beta = 0.55,
## 95% CI [-0.65, 1.76])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 15.53, 95% CI [-19.22, 50.28], t(2038) = 0.88, p = 0.381; Std. beta = 0.91,
## 95% CI [-1.13, 2.95])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.18, 95% CI [1.52, 34.84], t(2038) = 2.14, p = 0.032; Std. beta = 1.46, 95%
## CI [0.44, 2.49])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.67, 95% CI [-14.92, 32.26], t(2038) = 0.72, p = 0.471; Std. beta = 0.63,
## 95% CI [-0.85, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.47, 95% CI [-4.31, 31.26], t(2038) = 1.49, p = 0.138; Std. beta = 0.78,
## 95% CI [-0.30, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.38, 95% CI [-25.32, 34.09], t(2038) = 0.29, p = 0.772; Std. beta = 0.66,
## 95% CI [-1.82, 3.14])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.72, 95% CI [-61.71, 4.27], t(2038) = -1.71, p = 0.088; Std. beta = -1.85,
## 95% CI [-4.17, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.51, 95% CI [-31.36, -1.66], t(2038) = -2.18, p = 0.029; Std. beta = -0.64,
## 95% CI [-1.57, 0.29])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.41, 95% CI [-29.80, 36.61], t(2038) = 0.20, p = 0.841; Std. beta = 0.20,
## 95% CI [-1.75, 2.15])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.03, 95% CI [-25.78, 21.71], t(2038) = -0.17, p = 0.867; Std. beta = 0.58,
## 95% CI [-1.48, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-9.08, 21.08], t(2038) = 0.78, p = 0.435; Std. beta = 0.47, 95%
## CI [-0.49, 1.43])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-13.02, 15.39], t(2038) = 0.16, p = 0.870; Std. beta = 0.30,
## 95% CI [-0.61, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-30.15, 34.31], t(2038) = 0.13, p = 0.899; Std. beta = 0.61,
## 95% CI [-1.30, 2.53])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.92, 95% CI [-11.88, 10.04], t(2038) = -0.16, p = 0.870; Std. beta = -0.23,
## 95% CI [-0.94, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.88, 95% CI [-28.25, 2.48], t(2038) = -1.64, p = 0.100; Std. beta = -0.50,
## 95% CI [-1.63, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-10.39, 16.50], t(2038) = 0.45, p = 0.656; Std. beta = 0.35,
## 95% CI [-0.47, 1.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-17.11, 12.88], t(2038) = -0.28, p = 0.782; Std. beta = -0.45,
## 95% CI [-1.38, 0.48])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -0.22, 95% CI [-19.41, 18.98], t(2038) = -0.02, p = 0.982; Std. beta = -0.88,
## 95% CI [-2.87, 1.11])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-39.39, 26.47], t(2038) = -0.38, p = 0.701; Std. beta = -0.27,
## 95% CI [-2.21, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-13.30, 16.87], t(2038) = 0.23, p = 0.817; Std. beta = 0.30,
## 95% CI [-0.60, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-9.40, 25.92], t(2038) = 0.92, p = 0.359; Std. beta = 0.35, 95%
## CI [-0.75, 1.46])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.78, 95% CI [-34.52, -1.04], t(2038) = -2.08, p = 0.037; Std. beta = -0.66,
## 95% CI [-1.76, 0.44])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.10, 95% CI [-13.32, 13.11], t(2038) = -0.02, p = 0.988; Std. beta = 0.10,
## 95% CI [-0.72, 0.92])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-17.41, 22.45], t(2038) = 0.25, p = 0.804; Std. beta = 1.33,
## 95% CI [0.08, 2.57])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.72, 1.07], t(2038) = -1.82, p = 0.069; Std. beta = -0.46,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 10.92, 95% CI [-5.69, 27.54], t(2038) = 1.29, p = 0.197; Std. beta = 0.56,
## 95% CI [-0.45, 1.56])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-0.96, 22.11], t(2038) = 1.80, p = 0.072; Std. beta = 0.49,
## 95% CI [-0.22, 1.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.80, 95% CI [-18.41, 48.02], t(2038) = 0.87, p = 0.382; Std. beta = -2.80,
## 95% CI [-4.95, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [1.39, 48.86], t(2038) = 2.08, p = 0.038; Std. beta = 1.68, 95%
## CI [0.17, 3.20])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-23.36, 15.80], t(2038) = -0.38, p = 0.705; Std. beta = 0.04,
## 95% CI [-1.28, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-12.79, 8.51], t(2038) = -0.39, p = 0.694; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.66, 95% CI [-0.09, 1.41], t(2038) = 1.73, p = 0.084;
## Std. beta = 0.11, 95% CI [-0.01, 0.23])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-41.62, 16.47], t(2038) = -0.85, p = 0.396;
## Std. beta = -1.17, 95% CI [-3.88, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-6.17, 14.15], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.37, 95% CI [-0.57, 1.32])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-14.29, 7.60], t(2038) = -0.60, p = 0.549; Std.
## beta = -0.31, 95% CI [-1.33, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-12.51, 11.87], t(2038) = -0.05, p = 0.959;
## Std. beta = -0.03, 95% CI [-1.17, 1.11])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-10.94, 8.09], t(2038) = -0.29, p = 0.769; Std.
## beta = -0.13, 95% CI [-1.02, 0.75])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-5.46, 1.13], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.20, 95% CI [-0.51, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.57, 95% CI [-13.03, 3.89], t(2038) = -1.06, p = 0.290; Std.
## beta = -0.43, 95% CI [-1.22, 0.36])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.77, 4.24], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.12, 95% CI [-0.16, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.70e-03, 95% CI [-4.94, 4.93], t(2038) = -1.47e-03, p =
## 0.999; Std. beta = -3.40e-04, 95% CI [-0.46, 0.46])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.92], t(2038) = 2.59, p = 0.010; Std.
## beta = 0.42, 95% CI [0.10, 0.74])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.10, 95% CI [1.76, 16.43], t(2038) = 2.43, p = 0.015; Std.
## beta = 0.85, 95% CI [0.16, 1.53])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.33, 4.76], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.16, 95% CI [-0.12, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 3.92, 95% CI [0.26, 7.59], t(2038) = 2.10, p = 0.036; Std.
## beta = 0.37, 95% CI [0.02, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.75, 95% CI [-3.57, 23.06], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.91, 95% CI [-0.33, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 9.26, 95% CI [2.63, 15.89], t(2038) = 2.74, p = 0.006; Std.
## beta = 0.86, 95% CI [0.24, 1.48])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-0.92, 10.36], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.44, 95% CI [-0.09, 0.97])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.73, 9.60], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.13, 95% CI [-0.63, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-8.15, 7.97], t(2038) = -0.02, p = 0.983; Std.
## beta = -8.15e-03, 95% CI [-0.76, 0.74])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-32.45, 42.00], t(2038) = 0.25, p = 0.801; Std.
## beta = 0.45, 95% CI [-3.03, 3.92])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-24.32, 20.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.19, 95% CI [-2.27, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-1.48, 9.24], t(2038) = 1.42, p = 0.156; Std.
## beta = 0.36, 95% CI [-0.14, 0.86])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.28, 95% CI [-12.95, 29.51], t(2038) = 0.76, p = 0.445; Std.
## beta = 0.77, 95% CI [-1.21, 2.75])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-5.10, 8.01], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.14, 95% CI [-0.48, 0.75])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.75, 9.19], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.25, 95% CI [-0.35, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-3.01, 14.72], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.55, 95% CI [-0.28, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-7.52, 3.27], t(2038) = -0.77, p = 0.440; Std.
## beta = -0.20, 95% CI [-0.70, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-6.88, 13.00], t(2038) = 0.60, p = 0.545; Std.
## beta = 0.29, 95% CI [-0.64, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-2.97, 7.08], t(2038) = 0.80, p = 0.422; Std.
## beta = 0.19, 95% CI [-0.28, 0.66])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.91, 95% CI [-9.88, 2.06], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.36, 95% CI [-0.92, 0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-31.86, 11.28], t(2038) = -0.94, p = 0.349;
## Std. beta = -0.96, 95% CI [-2.97, 1.05])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.12, 10.62], t(2038) = 0.26, p = 0.793; Std.
## beta = 0.12, 95% CI [-0.76, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-1.79, 6.53], t(2038) = 1.12, p = 0.265; Std.
## beta = 0.22, 95% CI [-0.17, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-8.48, 5.37], t(2038) = -0.44, p = 0.659; Std.
## beta = -0.15, 95% CI [-0.79, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-3.06, 12.17], t(2038) = 1.17, p = 0.241; Std.
## beta = 0.42, 95% CI [-0.28, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.66, 6.22], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.12, 95% CI [-0.34, 0.58])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.04, 95% CI [5.58, 22.50], t(2038) = 3.25, p = 0.001; Std.
## beta = 1.31, 95% CI [0.52, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.42, 9.71], t(2038) = 1.46, p = 0.144; Std.
## beta = 0.39, 95% CI [-0.13, 0.91])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.50, 4.51], t(2038) = -0.36, p = 0.723; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-5.50, 2.38], t(2038) = -0.78, p = 0.437; Std.
## beta = -0.15, 95% CI [-0.51, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -43.61, 95% CI [-60.57, -26.65], t(2038) = -5.04, p < .001;
## Std. beta = -4.07, 95% CI [-5.65, -2.48])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-6.55, 11.59], t(2038) = 0.54, p = 0.586; Std.
## beta = 0.23, 95% CI [-0.61, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-7.89, 14.16], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.29, 95% CI [-0.74, 1.32])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-8.20, 13.11], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.23, 95% CI [-0.76, 1.22])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*SO4_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14185.5
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2602 -0.4395 -0.0152 0.4491 4.5699
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 231.60 15.218
## time_firstPFT 13.42 3.664 -0.06
## Residual 25.76 5.076
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 31.21199 7.73856 4.033
## time_firstPFT -4.47689 3.07531 -1.456
## SO4_5yrPreDx 0.13347 0.97686 0.137
## disadv 4.14478 2.90626 1.426
## dich_RaceNon-White -7.35829 2.80992 -2.619
## sexF 3.57109 1.75473 2.035
## age_dx 0.38929 0.09184 4.239
## smokeHxFormer 3.70826 1.72726 2.147
## smokeHxAlways 18.51683 8.39390 2.206
## smokeHxUnknown -2.40378 3.94902 -0.609
## site02R -10.81228 16.48460 -0.656
## site03R 12.40798 12.09112 1.026
## site04R 3.28752 11.44420 0.287
## site05R -12.43352 9.34361 -1.331
## site06R 10.78272 16.23750 0.664
## site07R 11.82301 5.03263 2.349
## site09R 20.69382 11.59435 1.785
## site101 4.63611 4.11564 1.126
## site102 12.87014 7.11161 1.810
## site103 -0.82037 4.48485 -0.183
## site104 -6.55684 7.18661 -0.912
## site105 4.87028 4.14518 1.175
## site106 -5.20794 4.74385 -1.098
## site107 -1.85919 11.74681 -0.158
## site108 5.49262 10.30295 0.533
## site10R 14.97239 17.27123 0.867
## site11R 17.48875 8.14711 2.147
## site12R 7.52338 11.54652 0.652
## site13R 17.62932 8.82447 1.998
## site14R 6.27762 14.81483 0.424
## site15R -33.87441 16.20169 -2.091
## site16R -8.86298 7.41744 -1.195
## site17R 10.60342 16.47530 0.644
## site18R -3.15254 11.63349 -0.271
## site19R 9.33180 7.44520 1.253
## site20R 2.57714 7.01483 0.367
## site21R 2.81264 15.72218 0.179
## site22R -2.31184 5.45933 -0.423
## site23R -12.94586 9.05022 -1.430
## site24R 5.09182 6.61655 0.770
## site25R 1.05751 7.47745 0.141
## site28R 4.24854 9.46587 0.449
## site29R -5.99778 16.17566 -0.371
## site31R 5.73510 7.53613 0.761
## site32R 9.81719 8.70752 1.127
## site33R -13.96444 8.23557 -1.696
## site34R 0.31206 6.49248 0.048
## site35R -0.11944 9.79042 -0.012
## site36R -11.27092 7.32369 -1.539
## site37R 15.79502 8.24821 1.915
## site38R 12.61965 5.67530 2.224
## site39R 24.37567 16.63571 1.465
## site40R 26.01722 11.60383 2.242
## site41R -2.75954 9.68137 -0.285
## site42R -0.77404 5.29756 -0.146
## time_firstPFT:SO4_5yrPreDx 0.58620 0.42132 1.391
## time_firstPFT:disadv -0.03119 1.10830 -0.028
## time_firstPFT:dich_RaceNon-White 0.02371 1.11293 0.021
## time_firstPFT:sexF -0.16531 0.66842 -0.247
## time_firstPFT:age_dx -0.04766 0.03500 -1.362
## time_firstPFT:smokeHxFormer 0.48474 0.67323 0.720
## time_firstPFT:smokeHxAlways 1.46130 5.30842 0.275
## time_firstPFT:smokeHxUnknown 1.03566 1.71153 0.605
## time_firstPFT:site02R -12.35628 14.87101 -0.831
## time_firstPFT:site03R 4.85917 5.30329 0.916
## time_firstPFT:site04R -3.19397 5.69252 -0.561
## time_firstPFT:site05R -0.07398 6.26642 -0.012
## time_firstPFT:site07R -2.01566 1.75157 -1.151
## time_firstPFT:site09R -4.71199 4.43304 -1.063
## time_firstPFT:site101 1.11664 1.59840 0.699
## time_firstPFT:site102 -0.42604 2.64798 -0.161
## time_firstPFT:site103 4.39577 1.88635 2.330
## time_firstPFT:site104 9.23537 3.86720 2.388
## time_firstPFT:site105 1.49825 1.63236 0.918
## time_firstPFT:site106 4.20176 1.96063 2.143
## time_firstPFT:site107 9.51377 6.85502 1.388
## time_firstPFT:site108 8.96049 3.65579 2.451
## time_firstPFT:site11R 5.24385 2.97016 1.766
## time_firstPFT:site12R 1.47542 4.26831 0.346
## time_firstPFT:site13R 0.10202 4.22384 0.024
## time_firstPFT:site14R 4.84010 19.02360 0.254
## time_firstPFT:site15R -1.82717 11.43488 -0.160
## time_firstPFT:site16R 3.50593 2.87347 1.220
## time_firstPFT:site18R 8.43982 10.87018 0.776
## time_firstPFT:site19R 1.81567 3.42435 0.530
## time_firstPFT:site20R 3.19839 3.42048 0.935
## time_firstPFT:site21R 5.72892 4.61114 1.242
## time_firstPFT:site22R -1.57475 2.83023 -0.556
## time_firstPFT:site23R 10.57853 24.76342 0.427
## time_firstPFT:site24R 1.82461 2.62937 0.694
## time_firstPFT:site25R -3.63566 3.16738 -1.148
## time_firstPFT:site28R -8.75861 11.12364 -0.787
## time_firstPFT:site29R 1.45931 4.91185 0.297
## time_firstPFT:site31R 2.29710 2.25247 1.020
## time_firstPFT:site32R -1.29614 3.62874 -0.357
## time_firstPFT:site33R 4.79374 4.00868 1.196
## time_firstPFT:site34R 1.21251 2.58721 0.469
## time_firstPFT:site35R 14.42662 4.38995 3.286
## time_firstPFT:site36R 4.23442 2.90685 1.457
## time_firstPFT:site37R -0.55459 2.96550 -0.187
## time_firstPFT:site38R -1.51354 2.06821 -0.732
## time_firstPFT:site39R -44.14754 8.82003 -5.005
## time_firstPFT:site40R 3.09946 4.77333 0.649
## time_firstPFT:site41R 3.51534 5.67871 0.619
## time_firstPFT:site42R 3.10297 5.45378 0.569##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.917
## Unadjusted ICC: 0.697report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SO4_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.24. The model's intercept,
## corresponding to time_firstPFT = 0, is at 31.21 (95% CI [16.04, 46.39], t(2008)
## = 4.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SO4_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to SO4_5yrPreDx
## = 0, is at 31.21 (95% CI [16.04, 46.39], t(2008) = 4.03, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to disadv = 0, is at 31.21 (95% CI [16.04,
## 46.39], t(2008) = 4.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to dich_Race = White, is at 31.21 (95% CI
## [16.04, 46.39], t(2008) = 4.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to sex = M, is at 31.21 (95% CI [16.04,
## 46.39], t(2008) = 4.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to age_dx = 0, is at 31.21 (95% CI [16.04,
## 46.39], t(2008) = 4.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to smokeHx = Never, is at 31.21 (95% CI
## [16.04, 46.39], t(2008) = 4.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to site = Simmons, is at 31.21 (95% CI [16.04,
## 46.39], t(2008) = 4.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to cohort =
## CARE-PF, is at 31.21 (95% CI [16.04, 46.39], t(2008) = 4.03, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.48, 95% CI [-10.51, 1.55], t(2008) = -1.46, p = 0.146; Std. beta =
## -0.54, 95% CI [-0.73, -0.35])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.13, 95% CI [-1.78, 2.05], t(2008) = 0.14, p = 0.891; Std. beta =
## 0.10, 95% CI [-0.12, 0.31])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.14, 95% CI [-1.55, 9.84], t(2008) = 1.43, p = 0.154; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.36, 95% CI [-12.87, -1.85], t(2008) = -2.62, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.08])
## - The effect of sex [F] is statistically significant and positive (beta = 3.57,
## 95% CI [0.13, 7.01], t(2008) = 2.04, p = 0.042; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.24, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.32, 7.10], t(2008) = 2.15, p = 0.032; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.98], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.40, 95% CI [-10.15, 5.34], t(2008) = -0.61, p = 0.543; Std. beta =
## -0.05, 95% CI [-0.56, 0.45])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.81, 95% CI [-43.14, 21.52], t(2008) = -0.66, p = 0.512; Std. beta =
## -1.68, 95% CI [-4.38, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.41, 95% CI [-11.30, 36.12], t(2008) = 1.03, p = 0.305; Std. beta = 1.14,
## 95% CI [-0.30, 2.57])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-19.16, 25.73], t(2008) = 0.29, p = 0.774; Std. beta = -0.08,
## 95% CI [-1.56, 1.41])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.43, 95% CI [-30.76, 5.89], t(2008) = -1.33, p = 0.183; Std. beta = -0.74,
## 95% CI [-2.06, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.78, 95% CI [-21.06, 42.63], t(2008) = 0.66, p = 0.507; Std. beta = 0.63,
## 95% CI [-1.23, 2.50])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.82, 95% CI [1.95, 21.69], t(2008) = 2.35, p = 0.019; Std. beta = 0.52, 95%
## CI [-0.09, 1.13])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.04, 43.43], t(2008) = 1.78, p = 0.074; Std. beta = 0.82,
## 95% CI [-0.63, 2.26])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.64, 95% CI [-3.44, 12.71], t(2008) = 1.13, p = 0.260; Std. beta = 0.37, 95%
## CI [-0.15, 0.88])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.87, 95% CI [-1.08, 26.82], t(2008) = 1.81, p = 0.070; Std. beta = 0.72,
## 95% CI [-0.15, 1.59])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-9.62, 7.98], t(2008) = -0.18, p = 0.855; Std. beta = 0.32,
## 95% CI [-0.24, 0.89])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.56, 95% CI [-20.65, 7.54], t(2008) = -0.91, p = 0.362; Std. beta = 0.40,
## 95% CI [-0.58, 1.37])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-3.26, 13.00], t(2008) = 1.17, p = 0.240; Std. beta = 0.41, 95%
## CI [-0.10, 0.93])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-14.51, 4.10], t(2008) = -1.10, p = 0.272; Std. beta = 0.05,
## 95% CI [-0.53, 0.63])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-24.90, 21.18], t(2008) = -0.16, p = 0.874; Std. beta = 0.69,
## 95% CI [-0.86, 2.25])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.49, 95% CI [-14.71, 25.70], t(2008) = 0.53, p = 0.594; Std. beta = 1.08,
## 95% CI [-0.16, 2.32])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.97, 95% CI [-18.90, 48.84], t(2008) = 0.87, p = 0.386; Std. beta = 0.88,
## 95% CI [-1.11, 2.86])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.49, 95% CI [1.51, 33.47], t(2008) = 2.15, p = 0.032; Std. beta = 1.47, 95%
## CI [0.47, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-15.12, 30.17], t(2008) = 0.65, p = 0.515; Std. beta = 0.57,
## 95% CI [-0.88, 2.01])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.32, 34.94], t(2008) = 2.00, p = 0.046; Std. beta = 1.04, 95%
## CI [-0.03, 2.11])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.28, 95% CI [-22.78, 35.33], t(2008) = 0.42, p = 0.672; Std. beta = 0.78,
## 95% CI [-1.70, 3.25])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.87, 95% CI [-65.65, -2.10], t(2008) = -2.09, p = 0.037; Std. beta = -2.14,
## 95% CI [-4.42, 0.14])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.41, 5.68], t(2008) = -1.19, p = 0.232; Std. beta = -0.22,
## 95% CI [-1.15, 0.71])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.60, 95% CI [-21.71, 42.91], t(2008) = 0.64, p = 0.520; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.15, 95% CI [-25.97, 19.66], t(2008) = -0.27, p = 0.786; Std. beta = 0.53,
## 95% CI [-1.51, 2.57])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.33, 95% CI [-5.27, 23.93], t(2008) = 1.25, p = 0.210; Std. beta = 0.70, 95%
## CI [-0.25, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-11.18, 16.33], t(2008) = 0.37, p = 0.713; Std. beta = 0.42,
## 95% CI [-0.48, 1.33])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.81, 95% CI [-28.02, 33.65], t(2008) = 0.18, p = 0.858; Std. beta = 0.65,
## 95% CI [-1.21, 2.50])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.31, 95% CI [-13.02, 8.39], t(2008) = -0.42, p = 0.672; Std. beta = -0.27,
## 95% CI [-0.98, 0.44])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.95, 95% CI [-30.69, 4.80], t(2008) = -1.43, p = 0.153; Std. beta = 0.13,
## 95% CI [-3.70, 3.96])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-7.88, 18.07], t(2008) = 0.77, p = 0.442; Std. beta = 0.45, 95%
## CI [-0.36, 1.26])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-13.61, 15.72], t(2008) = 0.14, p = 0.888; Std. beta = -0.24,
## 95% CI [-1.17, 0.68])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.32, 22.81], t(2008) = 0.45, p = 0.654; Std. beta = -0.49,
## 95% CI [-2.49, 1.51])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-37.72, 25.73], t(2008) = -0.37, p = 0.711; Std. beta = -0.23,
## 95% CI [-2.11, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-9.04, 20.51], t(2008) = 0.76, p = 0.447; Std. beta = 0.53, 95%
## CI [-0.37, 1.43])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.82, 95% CI [-7.26, 26.89], t(2008) = 1.13, p = 0.260; Std. beta = 0.47, 95%
## CI [-0.62, 1.55])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-30.12, 2.19], t(2008) = -1.70, p = 0.090; Std. beta = -0.41,
## 95% CI [-1.50, 0.67])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.31, 95% CI [-12.42, 13.04], t(2008) = 0.05, p = 0.962; Std. beta = 0.12,
## 95% CI [-0.68, 0.92])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.32, 19.08], t(2008) = -0.01, p = 0.990; Std. beta = 1.21,
## 95% CI [-0.01, 2.43])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.27, 95% CI [-25.63, 3.09], t(2008) = -1.54, p = 0.124; Std. beta = -0.30,
## 95% CI [-1.22, 0.61])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.80, 95% CI [-0.38, 31.97], t(2008) = 1.91, p = 0.056; Std. beta = 0.88,
## 95% CI [-0.12, 1.88])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.62, 95% CI [1.49, 23.75], t(2008) = 2.22, p = 0.026; Std. beta = 0.61, 95%
## CI [-0.08, 1.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.38, 95% CI [-8.25, 57.00], t(2008) = 1.47, p = 0.143; Std. beta = -2.30,
## 95% CI [-4.45, -0.14])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.02, 95% CI [3.26, 48.77], t(2008) = 2.24, p = 0.025; Std. beta = 1.79, 95%
## CI [0.31, 3.27])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.76, 95% CI [-21.75, 16.23], t(2008) = -0.29, p = 0.776; Std. beta = 0.13,
## 95% CI [-1.17, 1.44])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.77, 95% CI [-11.16, 9.62], t(2008) = -0.15, p = 0.884; Std. beta = 0.22,
## 95% CI [-0.73, 1.16])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.59, 95% CI [-0.24, 1.41], t(2008) = 1.39, p = 0.164;
## Std. beta = 0.09, 95% CI [-0.04, 0.23])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.03, 95% CI [-2.20, 2.14], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.35e-04, 95% CI [-0.06, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.02, 95% CI [-2.16, 2.21], t(2008) =
## 0.02, p = 0.983; Std. beta = 2.22e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-1.48, 1.15], t(2008) = -0.25, p = 0.805; Std.
## beta = -0.02, 95% CI [-0.14, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.48, 95% CI [-0.84, 1.81], t(2008) =
## 0.72, p = 0.472; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.46, 95% CI [-8.95, 11.87], t(2008) =
## 0.28, p = 0.783; Std. beta = 0.14, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.04, 95% CI [-2.32, 4.39], t(2008) =
## 0.61, p = 0.545; Std. beta = 0.10, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -12.36, 95% CI [-41.52, 16.81], t(2008) = -0.83, p = 0.406;
## Std. beta = -1.15, 95% CI [-3.88, 1.57])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-5.54, 15.26], t(2008) = 0.92, p = 0.360; Std.
## beta = 0.45, 95% CI [-0.52, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-14.36, 7.97], t(2008) = -0.56, p = 0.575; Std.
## beta = -0.30, 95% CI [-1.34, 0.74])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-12.36, 12.22], t(2008) = -0.01, p = 0.991;
## Std. beta = -6.91e-03, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-5.45, 1.42], t(2008) = -1.15, p = 0.250; Std.
## beta = -0.19, 95% CI [-0.51, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-13.41, 3.98], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.44, 95% CI [-1.25, 0.37])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-2.02, 4.25], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.10, 95% CI [-0.19, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-5.62, 4.77], t(2008) = -0.16, p = 0.872; Std.
## beta = -0.04, 95% CI [-0.53, 0.45])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.40, 95% CI [0.70, 8.10], t(2008) = 2.33, p = 0.020; Std.
## beta = 0.41, 95% CI [0.07, 0.76])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 9.24, 95% CI [1.65, 16.82], t(2008) = 2.39, p = 0.017; Std.
## beta = 0.86, 95% CI [0.15, 1.57])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-1.70, 4.70], t(2008) = 0.92, p = 0.359; Std.
## beta = 0.14, 95% CI [-0.16, 0.44])
## - The effect of time firstPFT × site [106] is statistically significant and
## positive (beta = 4.20, 95% CI [0.36, 8.05], t(2008) = 2.14, p = 0.032; Std.
## beta = 0.39, 95% CI [0.03, 0.75])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 9.51, 95% CI [-3.93, 22.96], t(2008) = 1.39, p = 0.165; Std.
## beta = 0.89, 95% CI [-0.37, 2.15])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.96, 95% CI [1.79, 16.13], t(2008) = 2.45, p = 0.014; Std.
## beta = 0.84, 95% CI [0.17, 1.51])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.58, 11.07], t(2008) = 1.77, p = 0.078; Std.
## beta = 0.49, 95% CI [-0.05, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-6.90, 9.85], t(2008) = 0.35, p = 0.730; Std.
## beta = 0.14, 95% CI [-0.64, 0.92])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-8.18, 8.39], t(2008) = 0.02, p = 0.981; Std.
## beta = 9.53e-03, 95% CI [-0.76, 0.78])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.84, 95% CI [-32.47, 42.15], t(2008) = 0.25, p = 0.799; Std.
## beta = 0.45, 95% CI [-3.03, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-24.25, 20.60], t(2008) = -0.16, p = 0.873;
## Std. beta = -0.17, 95% CI [-2.27, 1.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-2.13, 9.14], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.33, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-12.88, 29.76], t(2008) = 0.78, p = 0.438; Std.
## beta = 0.79, 95% CI [-1.20, 2.78])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-4.90, 8.53], t(2008) = 0.53, p = 0.596; Std.
## beta = 0.17, 95% CI [-0.46, 0.80])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-3.51, 9.91], t(2008) = 0.94, p = 0.350; Std.
## beta = 0.30, 95% CI [-0.33, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-3.31, 14.77], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.54, 95% CI [-0.31, 1.38])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.13, 3.98], t(2008) = -0.56, p = 0.578; Std.
## beta = -0.15, 95% CI [-0.67, 0.37])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.58, 95% CI [-37.99, 59.14], t(2008) = 0.43, p = 0.669; Std.
## beta = 0.99, 95% CI [-3.55, 5.53])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-3.33, 6.98], t(2008) = 0.69, p = 0.488; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-9.85, 2.58], t(2008) = -1.15, p = 0.251; Std.
## beta = -0.34, 95% CI [-0.92, 0.24])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.76, 95% CI [-30.57, 13.06], t(2008) = -0.79, p = 0.431;
## Std. beta = -0.82, 95% CI [-2.86, 1.22])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-8.17, 11.09], t(2008) = 0.30, p = 0.766; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-2.12, 6.71], t(2008) = 1.02, p = 0.308; Std.
## beta = 0.21, 95% CI [-0.20, 0.63])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.30, 95% CI [-8.41, 5.82], t(2008) = -0.36, p = 0.721; Std.
## beta = -0.12, 95% CI [-0.79, 0.54])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-3.07, 12.66], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.45, 95% CI [-0.29, 1.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-3.86, 6.29], t(2008) = 0.47, p = 0.639; Std.
## beta = 0.11, 95% CI [-0.36, 0.59])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 14.43, 95% CI [5.82, 23.04], t(2008) = 3.29, p = 0.001; Std.
## beta = 1.35, 95% CI [0.54, 2.15])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-1.47, 9.94], t(2008) = 1.46, p = 0.145; Std.
## beta = 0.40, 95% CI [-0.14, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-6.37, 5.26], t(2008) = -0.19, p = 0.852; Std.
## beta = -0.05, 95% CI [-0.60, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.51, 95% CI [-5.57, 2.54], t(2008) = -0.73, p = 0.464; Std.
## beta = -0.14, 95% CI [-0.52, 0.24])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.15, 95% CI [-61.44, -26.85], t(2008) = -5.01, p < .001;
## Std. beta = -4.13, 95% CI [-5.74, -2.51])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-6.26, 12.46], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.29, 95% CI [-0.59, 1.16])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-7.62, 14.65], t(2008) = 0.62, p = 0.536; Std.
## beta = 0.33, 95% CI [-0.71, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-7.59, 13.80], t(2008) = 0.57, p = 0.569; Std.
## beta = 0.29, 95% CI [-0.71, 1.29])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*NO3_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14374.2
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3115 -0.4367 -0.0166 0.4479 4.5248
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 255.44 15.98
## time_firstPFT 13.03 3.61 -0.11
## Residual 25.70 5.07
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 62.20478 3.05755 20.345
## time_firstPFT -3.93597 1.20972 -3.254
## NO3_5yrPreDx -2.40381 2.38471 -1.008
## site02R -7.26915 16.79432 -0.433
## site03R 14.31285 12.05304 1.187
## site04R 5.54426 11.93194 0.465
## site05R -10.75312 9.69964 -1.109
## site06R 19.60999 11.94223 1.642
## site07R 13.68687 4.79924 2.852
## site09R 20.89919 11.83736 1.766
## site101 2.76019 3.26374 0.846
## site102 10.25203 6.38904 1.605
## site103 -2.63035 3.26594 -0.805
## site104 -7.57376 6.80128 -1.114
## site105 3.78197 3.28081 1.153
## site106 -3.73160 4.17416 -0.894
## site107 -5.55506 11.91318 -0.466
## site108 -1.56525 9.76167 -0.160
## site10R 12.89932 17.48762 0.738
## site11R 18.69268 8.47115 2.207
## site12R 12.78731 11.81282 1.082
## site13R 15.42657 8.86533 1.740
## site14R 6.79973 14.97861 0.454
## site15R -29.31996 16.91225 -1.734
## site16R -14.69815 7.48011 -1.965
## site17R 6.31622 16.82125 0.375
## site18R -0.85130 12.00769 -0.071
## site19R 7.64531 7.31570 1.045
## site20R 4.17682 6.94039 0.602
## site21R 2.84917 16.41969 0.174
## site22R 1.80257 5.27000 0.342
## site23R -11.46582 7.66390 -1.496
## site24R 7.59562 6.52068 1.165
## site25R 3.03861 7.02675 0.432
## site28R 2.01882 9.83326 0.205
## site29R -4.62086 16.67889 -0.277
## site31R 2.84471 7.55533 0.377
## site32R 10.57057 8.53935 1.238
## site33R -16.94322 8.46468 -2.002
## site34R 2.04858 6.38318 0.321
## site35R 4.48681 9.86488 0.455
## site36R -11.44362 7.56329 -1.513
## site37R 13.76027 8.33366 1.651
## site38R 11.12441 5.82555 1.910
## site39R 17.31799 16.69528 1.037
## site40R 30.68703 11.91061 2.576
## site41R -0.46934 9.67025 -0.049
## site42R -0.08245 5.19482 -0.016
## time_firstPFT:NO3_5yrPreDx -0.23044 0.93748 -0.246
## time_firstPFT:site02R -15.02315 14.75270 -1.018
## time_firstPFT:site03R 1.69153 5.02347 0.337
## time_firstPFT:site04R -4.83761 5.57360 -0.868
## time_firstPFT:site05R -0.77633 6.22066 -0.125
## time_firstPFT:site06R -3.06016 4.79637 -0.638
## time_firstPFT:site07R -3.78905 1.40671 -2.694
## time_firstPFT:site09R -6.37050 4.23056 -1.506
## time_firstPFT:site101 -0.74486 1.07775 -0.691
## time_firstPFT:site102 -2.56764 2.09013 -1.228
## time_firstPFT:site103 1.80955 1.17138 1.545
## time_firstPFT:site104 6.28061 3.53203 1.778
## time_firstPFT:site105 -0.37368 1.10029 -0.340
## time_firstPFT:site106 2.06857 1.57625 1.312
## time_firstPFT:site107 7.57905 6.70867 1.130
## time_firstPFT:site108 6.41027 3.14113 2.041
## time_firstPFT:site11R 3.09525 2.85760 1.083
## time_firstPFT:site12R -0.05146 4.15004 -0.012
## time_firstPFT:site13R -1.84396 4.02102 -0.459
## time_firstPFT:site14R 3.26360 18.95664 0.172
## time_firstPFT:site15R -3.06763 11.40339 -0.269
## time_firstPFT:site16R 2.37675 2.61853 0.908
## time_firstPFT:site18R 6.55363 10.80241 0.607
## time_firstPFT:site19R -1.20168 3.18008 -0.378
## time_firstPFT:site20R 0.85791 3.14997 0.272
## time_firstPFT:site21R 4.31761 4.52314 0.955
## time_firstPFT:site22R -3.50953 2.65539 -1.322
## time_firstPFT:site23R 1.26950 5.05447 0.251
## time_firstPFT:site24R 0.14140 2.35683 0.060
## time_firstPFT:site25R -6.38123 2.71055 -2.354
## time_firstPFT:site28R -11.22214 10.98895 -1.021
## time_firstPFT:site29R -0.65507 4.72004 -0.139
## time_firstPFT:site31R 0.61563 2.01683 0.305
## time_firstPFT:site32R -4.10253 3.30456 -1.241
## time_firstPFT:site33R 2.93202 3.88215 0.755
## time_firstPFT:site34R -0.57132 2.33419 -0.245
## time_firstPFT:site35R 11.62187 4.17879 2.781
## time_firstPFT:site36R 3.46618 2.85806 1.213
## time_firstPFT:site37R -2.23265 2.74871 -0.812
## time_firstPFT:site38R -3.16890 1.92690 -1.645
## time_firstPFT:site39R -46.22446 8.57208 -5.392
## time_firstPFT:site40R -0.10842 4.44088 -0.024
## time_firstPFT:site41R 1.24229 5.52663 0.225
## time_firstPFT:site42R 1.27228 5.38798 0.236##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.920
## Unadjusted ICC: 0.740report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NO3_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 62.20 (95% CI [56.21,
## 68.20], t(2038) = 20.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.94, 95% CI [-6.31, -1.56], t(2038) = -3.25, p = 0.001; Std. beta = -0.39,
## 95% CI [-0.48, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.40, 95% CI [-7.08, 2.27], t(2038) = -1.01, p = 0.314; Std. beta =
## -0.07, 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-40.20, 25.67], t(2038) = -0.43, p = 0.665; Std. beta = -1.69,
## 95% CI [-4.38, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.31, 95% CI [-9.32, 37.95], t(2038) = 1.19, p = 0.235; Std. beta = 0.98,
## 95% CI [-0.41, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-17.86, 28.94], t(2038) = 0.46, p = 0.642; Std. beta = -0.08,
## 95% CI [-1.59, 1.42])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-29.78, 8.27], t(2038) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.03, 0.64])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.81, 43.03], t(2038) = 1.64, p = 0.101; Std. beta = 0.89,
## 95% CI [-0.58, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.69, 95% CI [4.27, 23.10], t(2038) = 2.85, p = 0.004; Std. beta = 0.48, 95%
## CI [-0.08, 1.04])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.90, 95% CI [-2.32, 44.11], t(2038) = 1.77, p = 0.078; Std. beta = 0.69,
## 95% CI [-0.75, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-3.64, 9.16], t(2038) = 0.85, p = 0.398; Std. beta = 0.10, 95%
## CI [-0.29, 0.49])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-2.28, 22.78], t(2038) = 1.60, p = 0.109; Std. beta = 0.39,
## 95% CI [-0.37, 1.14])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-9.04, 3.77], t(2038) = -0.81, p = 0.421; Std. beta =
## -2.08e-03, 95% CI [-0.40, 0.39])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-20.91, 5.76], t(2038) = -1.11, p = 0.266; Std. beta = 0.08,
## 95% CI [-0.82, 0.98])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.65, 10.22], t(2038) = 1.15, p = 0.249; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.73, 95% CI [-11.92, 4.45], t(2038) = -0.89, p = 0.371; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.56, 95% CI [-28.92, 17.81], t(2038) = -0.47, p = 0.641; Std. beta = 0.31,
## 95% CI [-1.23, 1.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-20.71, 17.58], t(2038) = -0.16, p = 0.873; Std. beta = 0.45,
## 95% CI [-0.69, 1.59])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-21.40, 47.19], t(2038) = 0.74, p = 0.461; Std. beta = 0.76,
## 95% CI [-1.25, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.69, 95% CI [2.08, 35.31], t(2038) = 2.21, p = 0.027; Std. beta = 1.36, 95%
## CI [0.34, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.79, 95% CI [-10.38, 35.95], t(2038) = 1.08, p = 0.279; Std. beta = 0.75,
## 95% CI [-0.70, 2.19])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.43, 95% CI [-1.96, 32.81], t(2038) = 1.74, p = 0.082; Std. beta = 0.75,
## 95% CI [-0.30, 1.80])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.80, 95% CI [-22.58, 36.17], t(2038) = 0.45, p = 0.650; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.32, 95% CI [-62.49, 3.85], t(2038) = -1.73, p = 0.083; Std. beta = -1.98,
## 95% CI [-4.30, 0.34])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.70, 95% CI [-29.37, -0.03], t(2038) = -1.96, p = 0.050; Std. beta = -0.66,
## 95% CI [-1.57, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.32, 95% CI [-26.67, 39.30], t(2038) = 0.38, p = 0.707; Std. beta = 0.37,
## 95% CI [-1.56, 2.30])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.85, 95% CI [-24.40, 22.70], t(2038) = -0.07, p = 0.943; Std. beta = 0.50,
## 95% CI [-1.54, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.65, 95% CI [-6.70, 21.99], t(2038) = 1.05, p = 0.296; Std. beta = 0.35, 95%
## CI [-0.56, 1.25])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.18, 95% CI [-9.43, 17.79], t(2038) = 0.60, p = 0.547; Std. beta = 0.32, 95%
## CI [-0.55, 1.18])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.85, 95% CI [-29.35, 35.05], t(2038) = 0.17, p = 0.862; Std. beta = 0.53,
## 95% CI [-1.37, 2.43])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-8.53, 12.14], t(2038) = 0.34, p = 0.732; Std. beta = -0.19,
## 95% CI [-0.86, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.47, 95% CI [-26.50, 3.56], t(2038) = -1.50, p = 0.135; Std. beta = -0.57,
## 95% CI [-1.68, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-5.19, 20.38], t(2038) = 1.16, p = 0.244; Std. beta = 0.46, 95%
## CI [-0.32, 1.23])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-10.74, 16.82], t(2038) = 0.43, p = 0.665; Std. beta = -0.36,
## 95% CI [-1.20, 0.48])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.27, 21.30], t(2038) = 0.21, p = 0.837; Std. beta = -0.83,
## 95% CI [-2.81, 1.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.62, 95% CI [-37.33, 28.09], t(2038) = -0.28, p = 0.782; Std. beta = -0.33,
## 95% CI [-2.23, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.84, 95% CI [-11.97, 17.66], t(2038) = 0.38, p = 0.707; Std. beta = 0.22,
## 95% CI [-0.66, 1.09])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.57, 95% CI [-6.18, 27.32], t(2038) = 1.24, p = 0.216; Std. beta = 0.27,
## 95% CI [-0.76, 1.31])
## - The effect of site [33R] is statistically significant and negative (beta =
## -16.94, 95% CI [-33.54, -0.34], t(2038) = -2.00, p = 0.045; Std. beta = -0.75,
## 95% CI [-1.83, 0.34])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-10.47, 14.57], t(2038) = 0.32, p = 0.748; Std. beta = 0.07,
## 95% CI [-0.69, 0.84])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-14.86, 23.83], t(2038) = 0.45, p = 0.649; Std. beta = 1.24,
## 95% CI [0.04, 2.44])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-26.28, 3.39], t(2038) = -1.51, p = 0.130; Std. beta = -0.38,
## 95% CI [-1.30, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.76, 95% CI [-2.58, 30.10], t(2038) = 1.65, p = 0.099; Std. beta = 0.62,
## 95% CI [-0.36, 1.60])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 11.12, 95% CI [-0.30, 22.55], t(2038) = 1.91, p = 0.056; Std. beta = 0.39,
## 95% CI [-0.30, 1.08])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.32, 95% CI [-15.42, 50.06], t(2038) = 1.04, p = 0.300; Std. beta = -2.87,
## 95% CI [-4.98, -0.76])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.69, 95% CI [7.33, 54.05], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.32, 3.26])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.47, 95% CI [-19.43, 18.50], t(2038) = -0.05, p = 0.961; Std. beta = 0.08,
## 95% CI [-1.20, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-10.27, 10.11], t(2038) = -0.02, p = 0.987; Std. beta = 0.10,
## 95% CI [-0.81, 1.02])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.23, 95% CI [-2.07, 1.61], t(2038) = -0.25, p = 0.806;
## Std. beta = -9.84e-03, 95% CI [-0.09, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.02, 95% CI [-43.96, 13.91], t(2038) = -1.02, p = 0.309;
## Std. beta = -1.40, 95% CI [-4.10, 1.30])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.69, 95% CI [-8.16, 11.54], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.16, 95% CI [-0.76, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.84, 95% CI [-15.77, 6.09], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.45, 95% CI [-1.47, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.12, p = 0.901;
## Std. beta = -0.07, 95% CI [-1.21, 1.07])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-12.47, 6.35], t(2038) = -0.64, p = 0.524; Std.
## beta = -0.29, 95% CI [-1.16, 0.59])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.79, 95% CI [-6.55, -1.03], t(2038) = -2.69, p = 0.007; Std.
## beta = -0.35, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.67, 1.93], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.59, 95% CI [-1.37, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-2.86, 1.37], t(2038) = -0.69, p = 0.490; Std.
## beta = -0.07, 95% CI [-0.27, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-6.67, 1.53], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.24, 95% CI [-0.62, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-0.49, 4.11], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.17, 95% CI [-0.05, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-0.65, 13.21], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.59, 95% CI [-0.06, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.53, 1.78], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.03, 95% CI [-0.24, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.02, 5.16], t(2038) = 1.31, p = 0.190; Std.
## beta = 0.19, 95% CI [-0.10, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.58, 20.74], t(2038) = 1.13, p = 0.259; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.41, 95% CI [0.25, 12.57], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.60, 95% CI [0.02, 1.17])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.51, 8.70], t(2038) = 1.08, p = 0.279; Std.
## beta = 0.29, 95% CI [-0.23, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-8.19, 8.09], t(2038) = -0.01, p = 0.990; Std.
## beta = -4.79e-03, 95% CI [-0.76, 0.75])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-9.73, 6.04], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.17, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.91, 40.44], t(2038) = 0.17, p = 0.863; Std.
## beta = 0.30, 95% CI [-3.16, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-25.43, 19.30], t(2038) = -0.27, p = 0.788;
## Std. beta = -0.29, 95% CI [-2.37, 1.80])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-2.76, 7.51], t(2038) = 0.91, p = 0.364; Std.
## beta = 0.22, 95% CI [-0.26, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-14.63, 27.74], t(2038) = 0.61, p = 0.544; Std.
## beta = 0.61, 95% CI [-1.36, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-7.44, 5.03], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-5.32, 7.04], t(2038) = 0.27, p = 0.785; Std.
## beta = 0.08, 95% CI [-0.50, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.32, 95% CI [-4.55, 13.19], t(2038) = 0.95, p = 0.340; Std.
## beta = 0.40, 95% CI [-0.42, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-8.72, 1.70], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.33, 95% CI [-0.81, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-8.64, 11.18], t(2038) = 0.25, p = 0.802; Std.
## beta = 0.12, 95% CI [-0.81, 1.04])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.48, 4.76], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.01, 95% CI [-0.42, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.70, -1.07], t(2038) = -2.35, p = 0.019;
## Std. beta = -0.59, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.22, 95% CI [-32.77, 10.33], t(2038) = -1.02, p = 0.307;
## Std. beta = -1.05, 95% CI [-3.06, 0.96])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-9.91, 8.60], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.06, 95% CI [-0.92, 0.80])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-3.34, 4.57], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.06, 95% CI [-0.31, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.10, 95% CI [-10.58, 2.38], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.38, 95% CI [-0.99, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-4.68, 10.55], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.27, 95% CI [-0.44, 0.98])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-5.15, 4.01], t(2038) = -0.24, p = 0.807; Std.
## beta = -0.05, 95% CI [-0.48, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.62, 95% CI [3.43, 19.82], t(2038) = 2.78, p = 0.005; Std.
## beta = 1.08, 95% CI [0.32, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.47, 95% CI [-2.14, 9.07], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-7.62, 3.16], t(2038) = -0.81, p = 0.417; Std.
## beta = -0.21, 95% CI [-0.71, 0.29])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-6.95, 0.61], t(2038) = -1.64, p = 0.100; Std.
## beta = -0.30, 95% CI [-0.65, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.22, 95% CI [-63.04, -29.41], t(2038) = -5.39, p < .001;
## Std. beta = -4.31, 95% CI [-5.88, -2.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-8.82, 8.60], t(2038) = -0.02, p = 0.981; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-9.60, 12.08], t(2038) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.89, 1.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-9.29, 11.84], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.12, 95% CI [-0.87, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NO3_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to NO3_5yrPreDx = 0, is at 62.20 (95% CI [56.21, 68.20], t(2038)
## = 20.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.94, 95% CI [-6.31, -1.56], t(2038) = -3.25, p = 0.001; Std. beta = -0.39,
## 95% CI [-0.48, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.40, 95% CI [-7.08, 2.27], t(2038) = -1.01, p = 0.314; Std. beta =
## -0.07, 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-40.20, 25.67], t(2038) = -0.43, p = 0.665; Std. beta = -1.69,
## 95% CI [-4.38, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.31, 95% CI [-9.32, 37.95], t(2038) = 1.19, p = 0.235; Std. beta = 0.98,
## 95% CI [-0.41, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-17.86, 28.94], t(2038) = 0.46, p = 0.642; Std. beta = -0.08,
## 95% CI [-1.59, 1.42])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-29.78, 8.27], t(2038) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.03, 0.64])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.81, 43.03], t(2038) = 1.64, p = 0.101; Std. beta = 0.89,
## 95% CI [-0.58, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.69, 95% CI [4.27, 23.10], t(2038) = 2.85, p = 0.004; Std. beta = 0.48, 95%
## CI [-0.08, 1.04])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.90, 95% CI [-2.32, 44.11], t(2038) = 1.77, p = 0.078; Std. beta = 0.69,
## 95% CI [-0.75, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-3.64, 9.16], t(2038) = 0.85, p = 0.398; Std. beta = 0.10, 95%
## CI [-0.29, 0.49])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-2.28, 22.78], t(2038) = 1.60, p = 0.109; Std. beta = 0.39,
## 95% CI [-0.37, 1.14])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-9.04, 3.77], t(2038) = -0.81, p = 0.421; Std. beta =
## -2.08e-03, 95% CI [-0.40, 0.39])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-20.91, 5.76], t(2038) = -1.11, p = 0.266; Std. beta = 0.08,
## 95% CI [-0.82, 0.98])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.65, 10.22], t(2038) = 1.15, p = 0.249; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.73, 95% CI [-11.92, 4.45], t(2038) = -0.89, p = 0.371; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.56, 95% CI [-28.92, 17.81], t(2038) = -0.47, p = 0.641; Std. beta = 0.31,
## 95% CI [-1.23, 1.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-20.71, 17.58], t(2038) = -0.16, p = 0.873; Std. beta = 0.45,
## 95% CI [-0.69, 1.59])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-21.40, 47.19], t(2038) = 0.74, p = 0.461; Std. beta = 0.76,
## 95% CI [-1.25, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.69, 95% CI [2.08, 35.31], t(2038) = 2.21, p = 0.027; Std. beta = 1.36, 95%
## CI [0.34, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.79, 95% CI [-10.38, 35.95], t(2038) = 1.08, p = 0.279; Std. beta = 0.75,
## 95% CI [-0.70, 2.19])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.43, 95% CI [-1.96, 32.81], t(2038) = 1.74, p = 0.082; Std. beta = 0.75,
## 95% CI [-0.30, 1.80])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.80, 95% CI [-22.58, 36.17], t(2038) = 0.45, p = 0.650; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.32, 95% CI [-62.49, 3.85], t(2038) = -1.73, p = 0.083; Std. beta = -1.98,
## 95% CI [-4.30, 0.34])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.70, 95% CI [-29.37, -0.03], t(2038) = -1.96, p = 0.050; Std. beta = -0.66,
## 95% CI [-1.57, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.32, 95% CI [-26.67, 39.30], t(2038) = 0.38, p = 0.707; Std. beta = 0.37,
## 95% CI [-1.56, 2.30])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.85, 95% CI [-24.40, 22.70], t(2038) = -0.07, p = 0.943; Std. beta = 0.50,
## 95% CI [-1.54, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.65, 95% CI [-6.70, 21.99], t(2038) = 1.05, p = 0.296; Std. beta = 0.35, 95%
## CI [-0.56, 1.25])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.18, 95% CI [-9.43, 17.79], t(2038) = 0.60, p = 0.547; Std. beta = 0.32, 95%
## CI [-0.55, 1.18])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.85, 95% CI [-29.35, 35.05], t(2038) = 0.17, p = 0.862; Std. beta = 0.53,
## 95% CI [-1.37, 2.43])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-8.53, 12.14], t(2038) = 0.34, p = 0.732; Std. beta = -0.19,
## 95% CI [-0.86, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.47, 95% CI [-26.50, 3.56], t(2038) = -1.50, p = 0.135; Std. beta = -0.57,
## 95% CI [-1.68, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-5.19, 20.38], t(2038) = 1.16, p = 0.244; Std. beta = 0.46, 95%
## CI [-0.32, 1.23])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-10.74, 16.82], t(2038) = 0.43, p = 0.665; Std. beta = -0.36,
## 95% CI [-1.20, 0.48])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.27, 21.30], t(2038) = 0.21, p = 0.837; Std. beta = -0.83,
## 95% CI [-2.81, 1.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.62, 95% CI [-37.33, 28.09], t(2038) = -0.28, p = 0.782; Std. beta = -0.33,
## 95% CI [-2.23, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.84, 95% CI [-11.97, 17.66], t(2038) = 0.38, p = 0.707; Std. beta = 0.22,
## 95% CI [-0.66, 1.09])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.57, 95% CI [-6.18, 27.32], t(2038) = 1.24, p = 0.216; Std. beta = 0.27,
## 95% CI [-0.76, 1.31])
## - The effect of site [33R] is statistically significant and negative (beta =
## -16.94, 95% CI [-33.54, -0.34], t(2038) = -2.00, p = 0.045; Std. beta = -0.75,
## 95% CI [-1.83, 0.34])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-10.47, 14.57], t(2038) = 0.32, p = 0.748; Std. beta = 0.07,
## 95% CI [-0.69, 0.84])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-14.86, 23.83], t(2038) = 0.45, p = 0.649; Std. beta = 1.24,
## 95% CI [0.04, 2.44])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-26.28, 3.39], t(2038) = -1.51, p = 0.130; Std. beta = -0.38,
## 95% CI [-1.30, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.76, 95% CI [-2.58, 30.10], t(2038) = 1.65, p = 0.099; Std. beta = 0.62,
## 95% CI [-0.36, 1.60])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 11.12, 95% CI [-0.30, 22.55], t(2038) = 1.91, p = 0.056; Std. beta = 0.39,
## 95% CI [-0.30, 1.08])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.32, 95% CI [-15.42, 50.06], t(2038) = 1.04, p = 0.300; Std. beta = -2.87,
## 95% CI [-4.98, -0.76])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.69, 95% CI [7.33, 54.05], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.32, 3.26])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.47, 95% CI [-19.43, 18.50], t(2038) = -0.05, p = 0.961; Std. beta = 0.08,
## 95% CI [-1.20, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-10.27, 10.11], t(2038) = -0.02, p = 0.987; Std. beta = 0.10,
## 95% CI [-0.81, 1.02])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.23, 95% CI [-2.07, 1.61], t(2038) = -0.25, p = 0.806;
## Std. beta = -9.84e-03, 95% CI [-0.09, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.02, 95% CI [-43.96, 13.91], t(2038) = -1.02, p = 0.309;
## Std. beta = -1.40, 95% CI [-4.10, 1.30])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.69, 95% CI [-8.16, 11.54], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.16, 95% CI [-0.76, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.84, 95% CI [-15.77, 6.09], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.45, 95% CI [-1.47, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.12, p = 0.901;
## Std. beta = -0.07, 95% CI [-1.21, 1.07])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-12.47, 6.35], t(2038) = -0.64, p = 0.524; Std.
## beta = -0.29, 95% CI [-1.16, 0.59])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.79, 95% CI [-6.55, -1.03], t(2038) = -2.69, p = 0.007; Std.
## beta = -0.35, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.67, 1.93], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.59, 95% CI [-1.37, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-2.86, 1.37], t(2038) = -0.69, p = 0.490; Std.
## beta = -0.07, 95% CI [-0.27, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-6.67, 1.53], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.24, 95% CI [-0.62, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-0.49, 4.11], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.17, 95% CI [-0.05, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-0.65, 13.21], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.59, 95% CI [-0.06, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.53, 1.78], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.03, 95% CI [-0.24, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.02, 5.16], t(2038) = 1.31, p = 0.190; Std.
## beta = 0.19, 95% CI [-0.10, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.58, 20.74], t(2038) = 1.13, p = 0.259; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.41, 95% CI [0.25, 12.57], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.60, 95% CI [0.02, 1.17])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.51, 8.70], t(2038) = 1.08, p = 0.279; Std.
## beta = 0.29, 95% CI [-0.23, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-8.19, 8.09], t(2038) = -0.01, p = 0.990; Std.
## beta = -4.79e-03, 95% CI [-0.76, 0.75])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-9.73, 6.04], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.17, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.91, 40.44], t(2038) = 0.17, p = 0.863; Std.
## beta = 0.30, 95% CI [-3.16, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-25.43, 19.30], t(2038) = -0.27, p = 0.788;
## Std. beta = -0.29, 95% CI [-2.37, 1.80])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-2.76, 7.51], t(2038) = 0.91, p = 0.364; Std.
## beta = 0.22, 95% CI [-0.26, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-14.63, 27.74], t(2038) = 0.61, p = 0.544; Std.
## beta = 0.61, 95% CI [-1.36, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-7.44, 5.03], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-5.32, 7.04], t(2038) = 0.27, p = 0.785; Std.
## beta = 0.08, 95% CI [-0.50, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.32, 95% CI [-4.55, 13.19], t(2038) = 0.95, p = 0.340; Std.
## beta = 0.40, 95% CI [-0.42, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-8.72, 1.70], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.33, 95% CI [-0.81, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-8.64, 11.18], t(2038) = 0.25, p = 0.802; Std.
## beta = 0.12, 95% CI [-0.81, 1.04])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.48, 4.76], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.01, 95% CI [-0.42, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.70, -1.07], t(2038) = -2.35, p = 0.019;
## Std. beta = -0.59, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.22, 95% CI [-32.77, 10.33], t(2038) = -1.02, p = 0.307;
## Std. beta = -1.05, 95% CI [-3.06, 0.96])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-9.91, 8.60], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.06, 95% CI [-0.92, 0.80])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-3.34, 4.57], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.06, 95% CI [-0.31, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.10, 95% CI [-10.58, 2.38], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.38, 95% CI [-0.99, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-4.68, 10.55], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.27, 95% CI [-0.44, 0.98])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-5.15, 4.01], t(2038) = -0.24, p = 0.807; Std.
## beta = -0.05, 95% CI [-0.48, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.62, 95% CI [3.43, 19.82], t(2038) = 2.78, p = 0.005; Std.
## beta = 1.08, 95% CI [0.32, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.47, 95% CI [-2.14, 9.07], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-7.62, 3.16], t(2038) = -0.81, p = 0.417; Std.
## beta = -0.21, 95% CI [-0.71, 0.29])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-6.95, 0.61], t(2038) = -1.64, p = 0.100; Std.
## beta = -0.30, 95% CI [-0.65, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.22, 95% CI [-63.04, -29.41], t(2038) = -5.39, p < .001;
## Std. beta = -4.31, 95% CI [-5.88, -2.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-8.82, 8.60], t(2038) = -0.02, p = 0.981; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-9.60, 12.08], t(2038) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.89, 1.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-9.29, 11.84], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.12, 95% CI [-0.87, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 62.20 (95% CI [56.21, 68.20], t(2038) = 20.34, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.94, 95% CI [-6.31, -1.56], t(2038) = -3.25, p = 0.001; Std. beta = -0.39,
## 95% CI [-0.48, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.40, 95% CI [-7.08, 2.27], t(2038) = -1.01, p = 0.314; Std. beta =
## -0.07, 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-40.20, 25.67], t(2038) = -0.43, p = 0.665; Std. beta = -1.69,
## 95% CI [-4.38, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.31, 95% CI [-9.32, 37.95], t(2038) = 1.19, p = 0.235; Std. beta = 0.98,
## 95% CI [-0.41, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-17.86, 28.94], t(2038) = 0.46, p = 0.642; Std. beta = -0.08,
## 95% CI [-1.59, 1.42])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-29.78, 8.27], t(2038) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.03, 0.64])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.81, 43.03], t(2038) = 1.64, p = 0.101; Std. beta = 0.89,
## 95% CI [-0.58, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.69, 95% CI [4.27, 23.10], t(2038) = 2.85, p = 0.004; Std. beta = 0.48, 95%
## CI [-0.08, 1.04])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.90, 95% CI [-2.32, 44.11], t(2038) = 1.77, p = 0.078; Std. beta = 0.69,
## 95% CI [-0.75, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-3.64, 9.16], t(2038) = 0.85, p = 0.398; Std. beta = 0.10, 95%
## CI [-0.29, 0.49])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-2.28, 22.78], t(2038) = 1.60, p = 0.109; Std. beta = 0.39,
## 95% CI [-0.37, 1.14])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-9.04, 3.77], t(2038) = -0.81, p = 0.421; Std. beta =
## -2.08e-03, 95% CI [-0.40, 0.39])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-20.91, 5.76], t(2038) = -1.11, p = 0.266; Std. beta = 0.08,
## 95% CI [-0.82, 0.98])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.65, 10.22], t(2038) = 1.15, p = 0.249; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.73, 95% CI [-11.92, 4.45], t(2038) = -0.89, p = 0.371; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.56, 95% CI [-28.92, 17.81], t(2038) = -0.47, p = 0.641; Std. beta = 0.31,
## 95% CI [-1.23, 1.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-20.71, 17.58], t(2038) = -0.16, p = 0.873; Std. beta = 0.45,
## 95% CI [-0.69, 1.59])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-21.40, 47.19], t(2038) = 0.74, p = 0.461; Std. beta = 0.76,
## 95% CI [-1.25, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.69, 95% CI [2.08, 35.31], t(2038) = 2.21, p = 0.027; Std. beta = 1.36, 95%
## CI [0.34, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.79, 95% CI [-10.38, 35.95], t(2038) = 1.08, p = 0.279; Std. beta = 0.75,
## 95% CI [-0.70, 2.19])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.43, 95% CI [-1.96, 32.81], t(2038) = 1.74, p = 0.082; Std. beta = 0.75,
## 95% CI [-0.30, 1.80])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.80, 95% CI [-22.58, 36.17], t(2038) = 0.45, p = 0.650; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.32, 95% CI [-62.49, 3.85], t(2038) = -1.73, p = 0.083; Std. beta = -1.98,
## 95% CI [-4.30, 0.34])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.70, 95% CI [-29.37, -0.03], t(2038) = -1.96, p = 0.050; Std. beta = -0.66,
## 95% CI [-1.57, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.32, 95% CI [-26.67, 39.30], t(2038) = 0.38, p = 0.707; Std. beta = 0.37,
## 95% CI [-1.56, 2.30])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.85, 95% CI [-24.40, 22.70], t(2038) = -0.07, p = 0.943; Std. beta = 0.50,
## 95% CI [-1.54, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.65, 95% CI [-6.70, 21.99], t(2038) = 1.05, p = 0.296; Std. beta = 0.35, 95%
## CI [-0.56, 1.25])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.18, 95% CI [-9.43, 17.79], t(2038) = 0.60, p = 0.547; Std. beta = 0.32, 95%
## CI [-0.55, 1.18])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.85, 95% CI [-29.35, 35.05], t(2038) = 0.17, p = 0.862; Std. beta = 0.53,
## 95% CI [-1.37, 2.43])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-8.53, 12.14], t(2038) = 0.34, p = 0.732; Std. beta = -0.19,
## 95% CI [-0.86, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.47, 95% CI [-26.50, 3.56], t(2038) = -1.50, p = 0.135; Std. beta = -0.57,
## 95% CI [-1.68, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-5.19, 20.38], t(2038) = 1.16, p = 0.244; Std. beta = 0.46, 95%
## CI [-0.32, 1.23])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-10.74, 16.82], t(2038) = 0.43, p = 0.665; Std. beta = -0.36,
## 95% CI [-1.20, 0.48])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.27, 21.30], t(2038) = 0.21, p = 0.837; Std. beta = -0.83,
## 95% CI [-2.81, 1.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.62, 95% CI [-37.33, 28.09], t(2038) = -0.28, p = 0.782; Std. beta = -0.33,
## 95% CI [-2.23, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.84, 95% CI [-11.97, 17.66], t(2038) = 0.38, p = 0.707; Std. beta = 0.22,
## 95% CI [-0.66, 1.09])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.57, 95% CI [-6.18, 27.32], t(2038) = 1.24, p = 0.216; Std. beta = 0.27,
## 95% CI [-0.76, 1.31])
## - The effect of site [33R] is statistically significant and negative (beta =
## -16.94, 95% CI [-33.54, -0.34], t(2038) = -2.00, p = 0.045; Std. beta = -0.75,
## 95% CI [-1.83, 0.34])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-10.47, 14.57], t(2038) = 0.32, p = 0.748; Std. beta = 0.07,
## 95% CI [-0.69, 0.84])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-14.86, 23.83], t(2038) = 0.45, p = 0.649; Std. beta = 1.24,
## 95% CI [0.04, 2.44])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-26.28, 3.39], t(2038) = -1.51, p = 0.130; Std. beta = -0.38,
## 95% CI [-1.30, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.76, 95% CI [-2.58, 30.10], t(2038) = 1.65, p = 0.099; Std. beta = 0.62,
## 95% CI [-0.36, 1.60])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 11.12, 95% CI [-0.30, 22.55], t(2038) = 1.91, p = 0.056; Std. beta = 0.39,
## 95% CI [-0.30, 1.08])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.32, 95% CI [-15.42, 50.06], t(2038) = 1.04, p = 0.300; Std. beta = -2.87,
## 95% CI [-4.98, -0.76])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.69, 95% CI [7.33, 54.05], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.32, 3.26])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.47, 95% CI [-19.43, 18.50], t(2038) = -0.05, p = 0.961; Std. beta = 0.08,
## 95% CI [-1.20, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-10.27, 10.11], t(2038) = -0.02, p = 0.987; Std. beta = 0.10,
## 95% CI [-0.81, 1.02])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.23, 95% CI [-2.07, 1.61], t(2038) = -0.25, p = 0.806;
## Std. beta = -9.84e-03, 95% CI [-0.09, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.02, 95% CI [-43.96, 13.91], t(2038) = -1.02, p = 0.309;
## Std. beta = -1.40, 95% CI [-4.10, 1.30])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.69, 95% CI [-8.16, 11.54], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.16, 95% CI [-0.76, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.84, 95% CI [-15.77, 6.09], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.45, 95% CI [-1.47, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.12, p = 0.901;
## Std. beta = -0.07, 95% CI [-1.21, 1.07])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-12.47, 6.35], t(2038) = -0.64, p = 0.524; Std.
## beta = -0.29, 95% CI [-1.16, 0.59])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.79, 95% CI [-6.55, -1.03], t(2038) = -2.69, p = 0.007; Std.
## beta = -0.35, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.67, 1.93], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.59, 95% CI [-1.37, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-2.86, 1.37], t(2038) = -0.69, p = 0.490; Std.
## beta = -0.07, 95% CI [-0.27, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-6.67, 1.53], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.24, 95% CI [-0.62, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-0.49, 4.11], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.17, 95% CI [-0.05, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-0.65, 13.21], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.59, 95% CI [-0.06, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.53, 1.78], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.03, 95% CI [-0.24, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.02, 5.16], t(2038) = 1.31, p = 0.190; Std.
## beta = 0.19, 95% CI [-0.10, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.58, 20.74], t(2038) = 1.13, p = 0.259; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.41, 95% CI [0.25, 12.57], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.60, 95% CI [0.02, 1.17])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.51, 8.70], t(2038) = 1.08, p = 0.279; Std.
## beta = 0.29, 95% CI [-0.23, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-8.19, 8.09], t(2038) = -0.01, p = 0.990; Std.
## beta = -4.79e-03, 95% CI [-0.76, 0.75])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-9.73, 6.04], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.17, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.91, 40.44], t(2038) = 0.17, p = 0.863; Std.
## beta = 0.30, 95% CI [-3.16, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-25.43, 19.30], t(2038) = -0.27, p = 0.788;
## Std. beta = -0.29, 95% CI [-2.37, 1.80])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-2.76, 7.51], t(2038) = 0.91, p = 0.364; Std.
## beta = 0.22, 95% CI [-0.26, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-14.63, 27.74], t(2038) = 0.61, p = 0.544; Std.
## beta = 0.61, 95% CI [-1.36, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-7.44, 5.03], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-5.32, 7.04], t(2038) = 0.27, p = 0.785; Std.
## beta = 0.08, 95% CI [-0.50, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.32, 95% CI [-4.55, 13.19], t(2038) = 0.95, p = 0.340; Std.
## beta = 0.40, 95% CI [-0.42, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-8.72, 1.70], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.33, 95% CI [-0.81, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-8.64, 11.18], t(2038) = 0.25, p = 0.802; Std.
## beta = 0.12, 95% CI [-0.81, 1.04])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.48, 4.76], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.01, 95% CI [-0.42, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.70, -1.07], t(2038) = -2.35, p = 0.019;
## Std. beta = -0.59, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.22, 95% CI [-32.77, 10.33], t(2038) = -1.02, p = 0.307;
## Std. beta = -1.05, 95% CI [-3.06, 0.96])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-9.91, 8.60], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.06, 95% CI [-0.92, 0.80])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-3.34, 4.57], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.06, 95% CI [-0.31, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.10, 95% CI [-10.58, 2.38], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.38, 95% CI [-0.99, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-4.68, 10.55], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.27, 95% CI [-0.44, 0.98])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-5.15, 4.01], t(2038) = -0.24, p = 0.807; Std.
## beta = -0.05, 95% CI [-0.48, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.62, 95% CI [3.43, 19.82], t(2038) = 2.78, p = 0.005; Std.
## beta = 1.08, 95% CI [0.32, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.47, 95% CI [-2.14, 9.07], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-7.62, 3.16], t(2038) = -0.81, p = 0.417; Std.
## beta = -0.21, 95% CI [-0.71, 0.29])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-6.95, 0.61], t(2038) = -1.64, p = 0.100; Std.
## beta = -0.30, 95% CI [-0.65, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.22, 95% CI [-63.04, -29.41], t(2038) = -5.39, p < .001;
## Std. beta = -4.31, 95% CI [-5.88, -2.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-8.82, 8.60], t(2038) = -0.02, p = 0.981; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-9.60, 12.08], t(2038) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.89, 1.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-9.29, 11.84], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.12, 95% CI [-0.87, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to cohort = CARE-PF, is at 62.20 (95% CI [56.21, 68.20], t(2038)
## = 20.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.94, 95% CI [-6.31, -1.56], t(2038) = -3.25, p = 0.001; Std. beta = -0.39,
## 95% CI [-0.48, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.40, 95% CI [-7.08, 2.27], t(2038) = -1.01, p = 0.314; Std. beta =
## -0.07, 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-40.20, 25.67], t(2038) = -0.43, p = 0.665; Std. beta = -1.69,
## 95% CI [-4.38, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.31, 95% CI [-9.32, 37.95], t(2038) = 1.19, p = 0.235; Std. beta = 0.98,
## 95% CI [-0.41, 2.38])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-17.86, 28.94], t(2038) = 0.46, p = 0.642; Std. beta = -0.08,
## 95% CI [-1.59, 1.42])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-29.78, 8.27], t(2038) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.03, 0.64])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.81, 43.03], t(2038) = 1.64, p = 0.101; Std. beta = 0.89,
## 95% CI [-0.58, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.69, 95% CI [4.27, 23.10], t(2038) = 2.85, p = 0.004; Std. beta = 0.48, 95%
## CI [-0.08, 1.04])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.90, 95% CI [-2.32, 44.11], t(2038) = 1.77, p = 0.078; Std. beta = 0.69,
## 95% CI [-0.75, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-3.64, 9.16], t(2038) = 0.85, p = 0.398; Std. beta = 0.10, 95%
## CI [-0.29, 0.49])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.25, 95% CI [-2.28, 22.78], t(2038) = 1.60, p = 0.109; Std. beta = 0.39,
## 95% CI [-0.37, 1.14])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-9.04, 3.77], t(2038) = -0.81, p = 0.421; Std. beta =
## -2.08e-03, 95% CI [-0.40, 0.39])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-20.91, 5.76], t(2038) = -1.11, p = 0.266; Std. beta = 0.08,
## 95% CI [-0.82, 0.98])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.65, 10.22], t(2038) = 1.15, p = 0.249; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.73, 95% CI [-11.92, 4.45], t(2038) = -0.89, p = 0.371; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.56, 95% CI [-28.92, 17.81], t(2038) = -0.47, p = 0.641; Std. beta = 0.31,
## 95% CI [-1.23, 1.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-20.71, 17.58], t(2038) = -0.16, p = 0.873; Std. beta = 0.45,
## 95% CI [-0.69, 1.59])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-21.40, 47.19], t(2038) = 0.74, p = 0.461; Std. beta = 0.76,
## 95% CI [-1.25, 2.77])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.69, 95% CI [2.08, 35.31], t(2038) = 2.21, p = 0.027; Std. beta = 1.36, 95%
## CI [0.34, 2.37])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.79, 95% CI [-10.38, 35.95], t(2038) = 1.08, p = 0.279; Std. beta = 0.75,
## 95% CI [-0.70, 2.19])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.43, 95% CI [-1.96, 32.81], t(2038) = 1.74, p = 0.082; Std. beta = 0.75,
## 95% CI [-0.30, 1.80])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.80, 95% CI [-22.58, 36.17], t(2038) = 0.45, p = 0.650; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.32, 95% CI [-62.49, 3.85], t(2038) = -1.73, p = 0.083; Std. beta = -1.98,
## 95% CI [-4.30, 0.34])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.70, 95% CI [-29.37, -0.03], t(2038) = -1.96, p = 0.050; Std. beta = -0.66,
## 95% CI [-1.57, 0.25])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.32, 95% CI [-26.67, 39.30], t(2038) = 0.38, p = 0.707; Std. beta = 0.37,
## 95% CI [-1.56, 2.30])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.85, 95% CI [-24.40, 22.70], t(2038) = -0.07, p = 0.943; Std. beta = 0.50,
## 95% CI [-1.54, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.65, 95% CI [-6.70, 21.99], t(2038) = 1.05, p = 0.296; Std. beta = 0.35, 95%
## CI [-0.56, 1.25])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.18, 95% CI [-9.43, 17.79], t(2038) = 0.60, p = 0.547; Std. beta = 0.32, 95%
## CI [-0.55, 1.18])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.85, 95% CI [-29.35, 35.05], t(2038) = 0.17, p = 0.862; Std. beta = 0.53,
## 95% CI [-1.37, 2.43])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-8.53, 12.14], t(2038) = 0.34, p = 0.732; Std. beta = -0.19,
## 95% CI [-0.86, 0.48])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.47, 95% CI [-26.50, 3.56], t(2038) = -1.50, p = 0.135; Std. beta = -0.57,
## 95% CI [-1.68, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-5.19, 20.38], t(2038) = 1.16, p = 0.244; Std. beta = 0.46, 95%
## CI [-0.32, 1.23])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-10.74, 16.82], t(2038) = 0.43, p = 0.665; Std. beta = -0.36,
## 95% CI [-1.20, 0.48])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.27, 21.30], t(2038) = 0.21, p = 0.837; Std. beta = -0.83,
## 95% CI [-2.81, 1.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.62, 95% CI [-37.33, 28.09], t(2038) = -0.28, p = 0.782; Std. beta = -0.33,
## 95% CI [-2.23, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.84, 95% CI [-11.97, 17.66], t(2038) = 0.38, p = 0.707; Std. beta = 0.22,
## 95% CI [-0.66, 1.09])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.57, 95% CI [-6.18, 27.32], t(2038) = 1.24, p = 0.216; Std. beta = 0.27,
## 95% CI [-0.76, 1.31])
## - The effect of site [33R] is statistically significant and negative (beta =
## -16.94, 95% CI [-33.54, -0.34], t(2038) = -2.00, p = 0.045; Std. beta = -0.75,
## 95% CI [-1.83, 0.34])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-10.47, 14.57], t(2038) = 0.32, p = 0.748; Std. beta = 0.07,
## 95% CI [-0.69, 0.84])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-14.86, 23.83], t(2038) = 0.45, p = 0.649; Std. beta = 1.24,
## 95% CI [0.04, 2.44])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-26.28, 3.39], t(2038) = -1.51, p = 0.130; Std. beta = -0.38,
## 95% CI [-1.30, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.76, 95% CI [-2.58, 30.10], t(2038) = 1.65, p = 0.099; Std. beta = 0.62,
## 95% CI [-0.36, 1.60])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 11.12, 95% CI [-0.30, 22.55], t(2038) = 1.91, p = 0.056; Std. beta = 0.39,
## 95% CI [-0.30, 1.08])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.32, 95% CI [-15.42, 50.06], t(2038) = 1.04, p = 0.300; Std. beta = -2.87,
## 95% CI [-4.98, -0.76])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.69, 95% CI [7.33, 54.05], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.32, 3.26])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.47, 95% CI [-19.43, 18.50], t(2038) = -0.05, p = 0.961; Std. beta = 0.08,
## 95% CI [-1.20, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-10.27, 10.11], t(2038) = -0.02, p = 0.987; Std. beta = 0.10,
## 95% CI [-0.81, 1.02])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.23, 95% CI [-2.07, 1.61], t(2038) = -0.25, p = 0.806;
## Std. beta = -9.84e-03, 95% CI [-0.09, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.02, 95% CI [-43.96, 13.91], t(2038) = -1.02, p = 0.309;
## Std. beta = -1.40, 95% CI [-4.10, 1.30])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.69, 95% CI [-8.16, 11.54], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.16, 95% CI [-0.76, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.84, 95% CI [-15.77, 6.09], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.45, 95% CI [-1.47, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.12, p = 0.901;
## Std. beta = -0.07, 95% CI [-1.21, 1.07])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-12.47, 6.35], t(2038) = -0.64, p = 0.524; Std.
## beta = -0.29, 95% CI [-1.16, 0.59])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.79, 95% CI [-6.55, -1.03], t(2038) = -2.69, p = 0.007; Std.
## beta = -0.35, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.67, 1.93], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.59, 95% CI [-1.37, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-2.86, 1.37], t(2038) = -0.69, p = 0.490; Std.
## beta = -0.07, 95% CI [-0.27, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-6.67, 1.53], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.24, 95% CI [-0.62, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-0.49, 4.11], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.17, 95% CI [-0.05, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-0.65, 13.21], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.59, 95% CI [-0.06, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.53, 1.78], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.03, 95% CI [-0.24, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.02, 5.16], t(2038) = 1.31, p = 0.190; Std.
## beta = 0.19, 95% CI [-0.10, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.58, 20.74], t(2038) = 1.13, p = 0.259; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.41, 95% CI [0.25, 12.57], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.60, 95% CI [0.02, 1.17])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.51, 8.70], t(2038) = 1.08, p = 0.279; Std.
## beta = 0.29, 95% CI [-0.23, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-8.19, 8.09], t(2038) = -0.01, p = 0.990; Std.
## beta = -4.79e-03, 95% CI [-0.76, 0.75])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-9.73, 6.04], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.17, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.91, 40.44], t(2038) = 0.17, p = 0.863; Std.
## beta = 0.30, 95% CI [-3.16, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-25.43, 19.30], t(2038) = -0.27, p = 0.788;
## Std. beta = -0.29, 95% CI [-2.37, 1.80])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-2.76, 7.51], t(2038) = 0.91, p = 0.364; Std.
## beta = 0.22, 95% CI [-0.26, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-14.63, 27.74], t(2038) = 0.61, p = 0.544; Std.
## beta = 0.61, 95% CI [-1.36, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-7.44, 5.03], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-5.32, 7.04], t(2038) = 0.27, p = 0.785; Std.
## beta = 0.08, 95% CI [-0.50, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.32, 95% CI [-4.55, 13.19], t(2038) = 0.95, p = 0.340; Std.
## beta = 0.40, 95% CI [-0.42, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-8.72, 1.70], t(2038) = -1.32, p = 0.186; Std.
## beta = -0.33, 95% CI [-0.81, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-8.64, 11.18], t(2038) = 0.25, p = 0.802; Std.
## beta = 0.12, 95% CI [-0.81, 1.04])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.48, 4.76], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.01, 95% CI [-0.42, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.70, -1.07], t(2038) = -2.35, p = 0.019;
## Std. beta = -0.59, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.22, 95% CI [-32.77, 10.33], t(2038) = -1.02, p = 0.307;
## Std. beta = -1.05, 95% CI [-3.06, 0.96])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-9.91, 8.60], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.06, 95% CI [-0.92, 0.80])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-3.34, 4.57], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.06, 95% CI [-0.31, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.10, 95% CI [-10.58, 2.38], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.38, 95% CI [-0.99, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-4.68, 10.55], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.27, 95% CI [-0.44, 0.98])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-5.15, 4.01], t(2038) = -0.24, p = 0.807; Std.
## beta = -0.05, 95% CI [-0.48, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.62, 95% CI [3.43, 19.82], t(2038) = 2.78, p = 0.005; Std.
## beta = 1.08, 95% CI [0.32, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.47, 95% CI [-2.14, 9.07], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-7.62, 3.16], t(2038) = -0.81, p = 0.417; Std.
## beta = -0.21, 95% CI [-0.71, 0.29])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-6.95, 0.61], t(2038) = -1.64, p = 0.100; Std.
## beta = -0.30, 95% CI [-0.65, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.22, 95% CI [-63.04, -29.41], t(2038) = -5.39, p < .001;
## Std. beta = -4.31, 95% CI [-5.88, -2.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-8.82, 8.60], t(2038) = -0.02, p = 0.981; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-9.60, 12.08], t(2038) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.89, 1.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-9.29, 11.84], t(2038) = 0.24, p = 0.813; Std.
## beta = 0.12, 95% CI [-0.87, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*NO3_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14183.7
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2810 -0.4394 -0.0160 0.4487 4.5103
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 231.99 15.231
## time_firstPFT 13.76 3.710 -0.07
## Residual 25.74 5.073
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 32.88420 6.75040 4.871
## time_firstPFT -1.01416 2.54711 -0.398
## NO3_5yrPreDx -0.84278 2.33815 -0.360
## disadv 4.02554 2.87226 1.402
## dich_RaceNon-White -7.18279 2.81083 -2.555
## sexF 3.64423 1.75935 2.071
## age_dx 0.38629 0.09140 4.226
## smokeHxFormer 3.73967 1.72858 2.163
## smokeHxAlways 18.44454 8.40478 2.195
## smokeHxUnknown -2.29902 3.92345 -0.586
## site02R -11.07055 16.16575 -0.685
## site03R 12.20351 11.69675 1.043
## site04R 3.79780 11.44031 0.332
## site05R -12.35011 9.34142 -1.322
## site06R 10.34177 16.13469 0.641
## site07R 11.91421 4.66177 2.556
## site09R 20.09104 11.39261 1.764
## site101 4.08521 3.19366 1.279
## site102 12.03619 6.21309 1.937
## site103 -1.95627 3.32360 -0.589
## site104 -7.82607 6.60460 -1.185
## site105 4.17168 3.21298 1.298
## site106 -5.50887 4.10496 -1.342
## site107 -2.43927 11.46574 -0.213
## site108 4.16595 9.84221 0.423
## site10R 10.79018 17.09833 0.631
## site11R 16.59332 8.13581 2.040
## site12R 7.58109 11.33508 0.669
## site13R 17.21253 8.58934 2.004
## site14R 5.77710 14.63306 0.395
## site15R -34.62236 16.29429 -2.125
## site16R -8.93149 7.27963 -1.227
## site17R 10.32944 16.29494 0.634
## site18R -3.87008 11.56021 -0.335
## site19R 8.06249 7.06983 1.140
## site20R 2.46192 6.68189 0.368
## site21R 2.17358 15.70089 0.138
## site22R -2.40034 5.16432 -0.465
## site23R -13.50527 8.85994 -1.524
## site24R 5.33476 6.28280 0.849
## site25R 1.13968 6.84074 0.167
## site28R 4.55823 9.48869 0.480
## site29R -6.62970 16.03918 -0.413
## site31R 4.91960 7.35007 0.669
## site32R 8.78973 8.24895 1.066
## site33R -14.63301 8.16005 -1.793
## site34R -0.16623 6.13588 -0.027
## site35R -1.01199 9.50607 -0.106
## site36R -11.10281 7.28798 -1.523
## site37R 15.84825 8.09193 1.959
## site38R 11.85307 5.61822 2.110
## site39R 23.22507 16.33505 1.422
## site40R 26.42369 11.47036 2.304
## site41R -3.03672 9.34788 -0.325
## site42R -0.94348 5.06878 -0.186
## time_firstPFT:NO3_5yrPreDx -0.40402 0.99018 -0.408
## time_firstPFT:disadv -0.22868 1.10719 -0.207
## time_firstPFT:dich_RaceNon-White 0.21308 1.13253 0.188
## time_firstPFT:sexF -0.01398 0.67693 -0.021
## time_firstPFT:age_dx -0.05380 0.03511 -1.532
## time_firstPFT:smokeHxFormer 0.39161 0.67539 0.580
## time_firstPFT:smokeHxAlways 1.24177 5.32027 0.233
## time_firstPFT:smokeHxUnknown 1.56723 1.69426 0.925
## time_firstPFT:site02R -14.32625 14.80559 -0.968
## time_firstPFT:site03R 2.87171 5.11324 0.562
## time_firstPFT:site04R -4.28804 5.67853 -0.755
## time_firstPFT:site05R -0.45140 6.26943 -0.072
## time_firstPFT:site07R -3.25984 1.49575 -2.179
## time_firstPFT:site09R -6.22142 4.34301 -1.433
## time_firstPFT:site101 -0.59332 1.11898 -0.530
## time_firstPFT:site102 -2.69247 2.15914 -1.247
## time_firstPFT:site103 1.88097 1.27705 1.473
## time_firstPFT:site104 6.66024 3.65048 1.824
## time_firstPFT:site105 -0.34647 1.13726 -0.305
## time_firstPFT:site106 2.61796 1.64717 1.589
## time_firstPFT:site107 7.59666 6.75586 1.124
## time_firstPFT:site108 6.25902 3.43363 1.823
## time_firstPFT:site11R 3.81215 2.94969 1.292
## time_firstPFT:site12R 0.52278 4.28584 0.122
## time_firstPFT:site13R -1.43609 4.11413 -0.349
## time_firstPFT:site14R 3.63676 18.99704 0.191
## time_firstPFT:site15R -2.83205 11.46538 -0.247
## time_firstPFT:site16R 2.11337 2.72944 0.774
## time_firstPFT:site18R 7.04183 10.85086 0.649
## time_firstPFT:site19R -0.53697 3.26135 -0.165
## time_firstPFT:site20R 1.57711 3.23820 0.487
## time_firstPFT:site21R 4.44991 4.61524 0.964
## time_firstPFT:site22R -2.65121 2.74000 -0.968
## time_firstPFT:site23R 9.38066 24.74355 0.379
## time_firstPFT:site24R 0.35591 2.41810 0.147
## time_firstPFT:site25R -5.66729 2.80789 -2.018
## time_firstPFT:site28R -9.63168 11.10851 -0.867
## time_firstPFT:site29R -0.17210 4.84292 -0.036
## time_firstPFT:site31R 0.60426 2.11822 0.285
## time_firstPFT:site32R -3.53031 3.39657 -1.039
## time_firstPFT:site33R 3.38937 4.01284 0.845
## time_firstPFT:site34R -0.34772 2.41054 -0.144
## time_firstPFT:site35R 12.43619 4.27220 2.911
## time_firstPFT:site36R 3.87092 2.94395 1.315
## time_firstPFT:site37R -1.56765 2.88716 -0.543
## time_firstPFT:site38R -3.01182 1.97920 -1.522
## time_firstPFT:site39R -46.76211 8.73172 -5.355
## time_firstPFT:site40R 0.98595 4.58729 0.215
## time_firstPFT:site41R 2.03367 5.58635 0.364
## time_firstPFT:site42R 2.18816 5.41397 0.404##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.917
## Unadjusted ICC: 0.691report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NO3_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 32.88 (95% CI [19.65, 46.12], t(2008)
## = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NO3_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to NO3_5yrPreDx
## = 0, is at 32.88 (95% CI [19.65, 46.12], t(2008) = 4.87, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 32.88 (95% CI [19.65,
## 46.12], t(2008) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to dich_Race = White, is at 32.88 (95% CI
## [19.65, 46.12], t(2008) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 32.88 (95% CI [19.65,
## 46.12], t(2008) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 32.88 (95% CI [19.65,
## 46.12], t(2008) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 32.88 (95% CI
## [19.65, 46.12], t(2008) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 32.88 (95% CI [19.65,
## 46.12], t(2008) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to cohort =
## CARE-PF, is at 32.88 (95% CI [19.65, 46.12], t(2008) = 4.87, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.01, 95% CI [-6.01, 3.98], t(2008) = -0.40, p = 0.691; Std. beta =
## -0.44, 95% CI [-0.58, -0.30])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -0.84, 95% CI [-5.43, 3.74], t(2008) = -0.36, p = 0.719; Std. beta =
## -0.04, 95% CI [-0.17, 0.10])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.03, 95% CI [-1.61, 9.66], t(2008) = 1.40, p = 0.161; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.18, 95% CI [-12.70, -1.67], t(2008) = -2.56, p = 0.011; Std. beta =
## -0.40, 95% CI [-0.75, -0.05])
## - The effect of sex [F] is statistically significant and positive (beta = 3.64,
## 95% CI [0.19, 7.09], t(2008) = 2.07, p = 0.038; Std. beta = 0.21, 95% CI
## [-3.64e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.23, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.74, 95% CI [0.35, 7.13], t(2008) = 2.16, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.44, 95% CI [1.96, 34.93], t(2008) = 2.19, p = 0.028; Std. beta =
## 1.19, 95% CI [0.01, 2.36])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.30, 95% CI [-9.99, 5.40], t(2008) = -0.59, p = 0.558; Std. beta =
## -2.49e-03, 95% CI [-0.50, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.07, 95% CI [-42.77, 20.63], t(2008) = -0.68, p = 0.494; Std. beta =
## -1.86, 95% CI [-4.52, 0.81])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.20, 95% CI [-10.74, 35.14], t(2008) = 1.04, p = 0.297; Std. beta = 0.96,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-18.64, 26.23], t(2008) = 0.33, p = 0.740; Std. beta = -0.14,
## 95% CI [-1.62, 1.34])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.35, 95% CI [-30.67, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-21.30, 41.98], t(2008) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.25, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.91, 95% CI [2.77, 21.06], t(2008) = 2.56, p = 0.011; Std. beta = 0.42, 95%
## CI [-0.13, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.09, 95% CI [-2.25, 42.43], t(2008) = 1.76, p = 0.078; Std. beta = 0.65,
## 95% CI [-0.76, 2.07])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-2.18, 10.35], t(2008) = 1.28, p = 0.201; Std. beta = 0.19, 95%
## CI [-0.20, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.04, 95% CI [-0.15, 24.22], t(2008) = 1.94, p = 0.053; Std. beta = 0.48,
## 95% CI [-0.26, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-8.47, 4.56], t(2008) = -0.59, p = 0.556; Std. beta = 0.04,
## 95% CI [-0.36, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-20.78, 5.13], t(2008) = -1.18, p = 0.236; Std. beta = 0.10,
## 95% CI [-0.80, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-2.13, 10.47], t(2008) = 1.30, p = 0.194; Std. beta = 0.22, 95%
## CI [-0.17, 0.60])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.51, 95% CI [-13.56, 2.54], t(2008) = -1.34, p = 0.180; Std. beta = -0.10,
## 95% CI [-0.60, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-24.93, 20.05], t(2008) = -0.21, p = 0.832; Std. beta = 0.50,
## 95% CI [-1.02, 2.01])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-15.14, 23.47], t(2008) = 0.42, p = 0.672; Std. beta = 0.77,
## 95% CI [-0.40, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 10.79, 95% CI [-22.74, 44.32], t(2008) = 0.63, p = 0.528; Std. beta = 0.63,
## 95% CI [-1.33, 2.60])
## - The effect of site [11R] is statistically significant and positive (beta =
## 16.59, 95% CI [0.64, 32.55], t(2008) = 2.04, p = 0.042; Std. beta = 1.29, 95%
## CI [0.30, 2.29])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-14.65, 29.81], t(2008) = 0.67, p = 0.504; Std. beta = 0.49,
## 95% CI [-0.93, 1.91])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.21, 95% CI [0.37, 34.06], t(2008) = 2.00, p = 0.045; Std. beta = 0.89, 95%
## CI [-0.15, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.78, 95% CI [-22.92, 34.47], t(2008) = 0.39, p = 0.693; Std. beta = 0.65,
## 95% CI [-1.81, 3.10])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.62, 95% CI [-66.58, -2.67], t(2008) = -2.12, p = 0.034; Std. beta = -2.27,
## 95% CI [-4.56, 0.02])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.93, 95% CI [-23.21, 5.34], t(2008) = -1.23, p = 0.220; Std. beta = -0.35,
## 95% CI [-1.25, 0.56])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-21.63, 42.29], t(2008) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.27, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-26.54, 18.80], t(2008) = -0.33, p = 0.738; Std. beta = 0.37,
## 95% CI [-1.66, 2.39])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.06, 95% CI [-5.80, 21.93], t(2008) = 1.14, p = 0.254; Std. beta = 0.43, 95%
## CI [-0.47, 1.32])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.46, 95% CI [-10.64, 15.57], t(2008) = 0.37, p = 0.713; Std. beta = 0.28,
## 95% CI [-0.58, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.17, 95% CI [-28.62, 32.97], t(2008) = 0.14, p = 0.890; Std. beta = 0.50,
## 95% CI [-1.34, 2.35])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.53, 7.73], t(2008) = -0.46, p = 0.642; Std. beta = -0.36,
## 95% CI [-1.03, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-30.88, 3.87], t(2008) = -1.52, p = 0.128; Std. beta =
## 1.07e-04, 95% CI [-3.82, 3.82])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-6.99, 17.66], t(2008) = 0.85, p = 0.396; Std. beta = 0.34, 95%
## CI [-0.42, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-12.28, 14.56], t(2008) = 0.17, p = 0.868; Std. beta = -0.41,
## 95% CI [-1.24, 0.42])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-14.05, 23.17], t(2008) = 0.48, p = 0.631; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-38.08, 24.83], t(2008) = -0.41, p = 0.679; Std. beta = -0.40,
## 95% CI [-2.26, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.92, 95% CI [-9.49, 19.33], t(2008) = 0.67, p = 0.503; Std. beta = 0.34, 95%
## CI [-0.53, 1.20])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 8.79, 95% CI [-7.39, 24.97], t(2008) = 1.07, p = 0.287; Std. beta = 0.22, 95%
## CI [-0.80, 1.24])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.63, 95% CI [-30.64, 1.37], t(2008) = -1.79, p = 0.073; Std. beta = -0.57,
## 95% CI [-1.65, 0.50])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.17, 95% CI [-12.20, 11.87], t(2008) = -0.03, p = 0.978; Std. beta = -0.04,
## 95% CI [-0.79, 0.71])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-19.65, 17.63], t(2008) = -0.11, p = 0.915; Std. beta = 0.99,
## 95% CI [-0.19, 2.17])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.10, 95% CI [-25.40, 3.19], t(2008) = -1.52, p = 0.128; Std. beta = -0.32,
## 95% CI [-1.24, 0.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-0.02, 31.72], t(2008) = 1.96, p = 0.050; Std. beta = 0.80,
## 95% CI [-0.17, 1.77])
## - The effect of site [38R] is statistically significant and positive (beta =
## 11.85, 95% CI [0.83, 22.87], t(2008) = 2.11, p = 0.035; Std. beta = 0.44, 95%
## CI [-0.24, 1.12])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.23, 95% CI [-8.81, 55.26], t(2008) = 1.42, p = 0.155; Std. beta = -2.59,
## 95% CI [-4.69, -0.48])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.42, 95% CI [3.93, 48.92], t(2008) = 2.30, p = 0.021; Std. beta = 1.63, 95%
## CI [0.18, 3.08])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-21.37, 15.30], t(2008) = -0.32, p = 0.745; Std. beta =
## -6.36e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.94, 95% CI [-10.88, 9.00], t(2008) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and negative (beta = -0.40, 95% CI [-2.35, 1.54], t(2008) = -0.41, p = 0.683;
## Std. beta = -0.02, 95% CI [-0.10, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.94], t(2008) = -0.21, p = 0.836; Std.
## beta = -6.12e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.21, 95% CI [-2.01, 2.43], t(2008) =
## 0.19, p = 0.851; Std. beta = 0.02, 95% CI [-0.19, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.01, 95% CI [-1.34, 1.31], t(2008) = -0.02, p = 0.984; Std.
## beta = -1.30e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.53, p = 0.126; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.39, 95% CI [-0.93, 1.72], t(2008) =
## 0.58, p = 0.562; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.24, 95% CI [-9.19, 11.68], t(2008) =
## 0.23, p = 0.815; Std. beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.57, 95% CI [-1.76, 4.89], t(2008) =
## 0.93, p = 0.355; Std. beta = 0.15, 95% CI [-0.16, 0.46])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.33, 95% CI [-43.36, 14.71], t(2008) = -0.97, p = 0.333;
## Std. beta = -1.34, 95% CI [-4.05, 1.37])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-7.16, 12.90], t(2008) = 0.56, p = 0.574; Std.
## beta = 0.27, 95% CI [-0.67, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-15.42, 6.85], t(2008) = -0.76, p = 0.450; Std.
## beta = -0.40, 95% CI [-1.44, 0.64])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.943;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.26, 95% CI [-6.19, -0.33], t(2008) = -2.18, p = 0.029; Std.
## beta = -0.30, 95% CI [-0.58, -0.03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.22, 95% CI [-14.74, 2.30], t(2008) = -1.43, p = 0.152; Std.
## beta = -0.58, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-2.79, 1.60], t(2008) = -0.53, p = 0.596; Std.
## beta = -0.06, 95% CI [-0.26, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-6.93, 1.54], t(2008) = -1.25, p = 0.213; Std.
## beta = -0.25, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-0.62, 4.39], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.18, 95% CI [-0.06, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-0.50, 13.82], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.62, 95% CI [-0.05, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.58, 1.88], t(2008) = -0.30, p = 0.761; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-0.61, 5.85], t(2008) = 1.59, p = 0.112; Std.
## beta = 0.24, 95% CI [-0.06, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.65, 20.85], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.71, 95% CI [-0.53, 1.95])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.26, 95% CI [-0.47, 12.99], t(2008) = 1.82, p = 0.068; Std.
## beta = 0.58, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-1.97, 9.60], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-7.88, 8.93], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.05, 95% CI [-0.74, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.50, 6.63], t(2008) = -0.35, p = 0.727; Std.
## beta = -0.13, 95% CI [-0.89, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-33.62, 40.89], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.83, 95% CI [-25.32, 19.65], t(2008) = -0.25, p = 0.805;
## Std. beta = -0.26, 95% CI [-2.37, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-3.24, 7.47], t(2008) = 0.77, p = 0.439; Std.
## beta = 0.20, 95% CI [-0.30, 0.70])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.04, 95% CI [-14.24, 28.32], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.66, 95% CI [-1.33, 2.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.93, 5.86], t(2008) = -0.16, p = 0.869; Std.
## beta = -0.05, 95% CI [-0.65, 0.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-4.77, 7.93], t(2008) = 0.49, p = 0.626; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.60, 13.50], t(2008) = 0.96, p = 0.335; Std.
## beta = 0.42, 95% CI [-0.43, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-8.02, 2.72], t(2008) = -0.97, p = 0.333; Std.
## beta = -0.25, 95% CI [-0.75, 0.25])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.38, 95% CI [-39.15, 57.91], t(2008) = 0.38, p = 0.705; Std.
## beta = 0.88, 95% CI [-3.66, 5.41])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-4.39, 5.10], t(2008) = 0.15, p = 0.883; Std.
## beta = 0.03, 95% CI [-0.41, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.67, 95% CI [-11.17, -0.16], t(2008) = -2.02, p = 0.044;
## Std. beta = -0.53, 95% CI [-1.04, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-31.42, 12.15], t(2008) = -0.87, p = 0.386;
## Std. beta = -0.90, 95% CI [-2.94, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-9.67, 9.33], t(2008) = -0.04, p = 0.972; Std.
## beta = -0.02, 95% CI [-0.90, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.55, 4.76], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.06, 95% CI [-0.33, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-10.19, 3.13], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.33, 95% CI [-0.95, 0.29])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-4.48, 11.26], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.32, 95% CI [-0.42, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-5.08, 4.38], t(2008) = -0.14, p = 0.885; Std.
## beta = -0.03, 95% CI [-0.47, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.44, 95% CI [4.06, 20.81], t(2008) = 2.91, p = 0.004; Std.
## beta = 1.16, 95% CI [0.38, 1.94])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-1.90, 9.64], t(2008) = 1.31, p = 0.189; Std.
## beta = 0.36, 95% CI [-0.18, 0.90])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.57, 95% CI [-7.23, 4.09], t(2008) = -0.54, p = 0.587; Std.
## beta = -0.15, 95% CI [-0.68, 0.38])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.89, 0.87], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.28, 95% CI [-0.64, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.76, 95% CI [-63.89, -29.64], t(2008) = -5.36, p < .001;
## Std. beta = -4.37, 95% CI [-5.97, -2.77])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-8.01, 9.98], t(2008) = 0.21, p = 0.830; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-8.92, 12.99], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.19, 95% CI [-0.83, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*NH4_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14372.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3033 -0.4379 -0.0208 0.4476 4.5695
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 254.42 15.951
## time_firstPFT 12.80 3.578 -0.09
## Residual 25.72 5.072
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 64.64045 3.87292 16.690
## time_firstPFT -5.78929 1.63133 -3.549
## NH4_5yrPreDx -3.31381 2.32247 -1.427
## site02R -12.09293 17.03477 -0.710
## site03R 10.19012 12.28518 0.829
## site04R 1.52460 11.77681 0.129
## site05R -11.56381 9.68189 -1.194
## site06R 17.13005 12.09735 1.416
## site07R 10.49675 4.98426 2.106
## site09R 18.99796 11.94259 1.591
## site101 -0.01652 3.96845 -0.004
## site102 7.02228 6.95927 1.009
## site103 -5.43118 4.23151 -1.284
## site104 -10.18512 7.25869 -1.403
## site105 1.19422 3.99660 0.299
## site106 -6.57236 4.62198 -1.422
## site107 -8.15879 12.09719 -0.674
## site108 -4.34426 10.10846 -0.430
## site10R 13.01905 17.81497 0.731
## site11R 16.76937 8.66987 1.934
## site12R 9.39940 11.86064 0.792
## site13R 13.09666 9.05836 1.446
## site14R 4.19564 15.10460 0.278
## site15R -29.55641 16.84664 -1.754
## site16R -15.98827 7.49786 -2.132
## site17R 3.32380 16.88940 0.197
## site18R -3.18731 12.19118 -0.261
## site19R 5.31599 7.65531 0.694
## site20R 1.35945 7.11866 0.191
## site21R 1.04386 16.48106 0.063
## site22R -0.71021 5.43975 -0.131
## site23R -13.62314 7.88643 -1.727
## site24R 3.77572 6.56824 0.575
## site25R -1.67818 7.32502 -0.229
## site28R 0.27771 9.75278 0.028
## site29R -6.63210 16.75030 -0.396
## site31R 1.03336 7.74479 0.133
## site32R 7.79177 8.92274 0.873
## site33R -18.52478 8.58707 -2.157
## site34R -0.20633 6.64430 -0.031
## site35R 2.01915 10.12254 0.199
## site36R -13.35809 7.52667 -1.775
## site37R 11.39900 8.36312 1.363
## site38R 9.69786 5.98680 1.620
## site39R 15.19709 16.78837 0.905
## site40R 26.43098 11.83046 2.234
## site41R -3.97843 9.91459 -0.401
## site42R -2.20222 5.36861 -0.410
## time_firstPFT:NH4_5yrPreDx 0.93408 0.93071 1.004
## time_firstPFT:site02R -13.71797 14.80910 -0.926
## time_firstPFT:site03R 2.78475 5.13441 0.542
## time_firstPFT:site04R -4.43130 5.53706 -0.800
## time_firstPFT:site05R -0.61332 6.21704 -0.099
## time_firstPFT:site06R -2.06136 4.86719 -0.424
## time_firstPFT:site07R -3.10106 1.56429 -1.982
## time_firstPFT:site09R -5.42792 4.30550 -1.261
## time_firstPFT:site101 0.28968 1.43990 0.201
## time_firstPFT:site102 -1.31837 2.38621 -0.552
## time_firstPFT:site103 3.33893 1.65634 2.016
## time_firstPFT:site104 7.94400 3.73271 2.128
## time_firstPFT:site105 0.73005 1.45458 0.502
## time_firstPFT:site106 3.03172 1.80400 1.681
## time_firstPFT:site107 8.77170 6.78036 1.294
## time_firstPFT:site108 8.05381 3.34977 2.404
## time_firstPFT:site11R 4.36940 2.97496 1.469
## time_firstPFT:site12R 0.22197 4.08434 0.054
## time_firstPFT:site13R -0.81512 4.11616 -0.198
## time_firstPFT:site14R 4.00700 18.97810 0.211
## time_firstPFT:site15R -2.20189 11.39345 -0.193
## time_firstPFT:site16R 3.03973 2.68406 1.133
## time_firstPFT:site18R 7.78439 10.84603 0.718
## time_firstPFT:site19R 0.40172 3.33465 0.120
## time_firstPFT:site20R 1.78827 3.26809 0.547
## time_firstPFT:site21R 5.44692 4.57055 1.192
## time_firstPFT:site22R -2.81517 2.72472 -1.033
## time_firstPFT:site23R 2.57861 5.11548 0.504
## time_firstPFT:site24R 0.84689 2.42888 0.349
## time_firstPFT:site25R -5.27489 2.91601 -1.809
## time_firstPFT:site28R -10.92413 10.99487 -0.994
## time_firstPFT:site29R 0.39608 4.77108 0.083
## time_firstPFT:site31R 1.76867 2.16379 0.817
## time_firstPFT:site32R -2.66910 3.50399 -0.762
## time_firstPFT:site33R 4.04901 3.91408 1.034
## time_firstPFT:site34R 0.40000 2.48041 0.161
## time_firstPFT:site35R 13.05517 4.31219 3.028
## time_firstPFT:site36R 3.58014 2.81695 1.271
## time_firstPFT:site37R -1.82655 2.75159 -0.664
## time_firstPFT:site38R -2.06284 2.06979 -0.997
## time_firstPFT:site39R -44.96685 8.61118 -5.222
## time_firstPFT:site40R 1.00117 4.52000 0.221
## time_firstPFT:site41R 2.21639 5.60536 0.395
## time_firstPFT:site42R 1.82460 5.42090 0.337##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.736report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NH4_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 64.64 (95% CI [57.05,
## 72.24], t(2038) = 16.69, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.79, 95% CI [-8.99, -2.59], t(2038) = -3.55, p < .001; Std. beta = -0.45, 95%
## CI [-0.59, -0.31])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -3.31, 95% CI [-7.87, 1.24], t(2038) = -1.43, p = 0.154; Std. beta =
## -0.08, 95% CI [-0.26, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.09, 95% CI [-45.50, 21.31], t(2038) = -0.71, p = 0.478; Std. beta =
## -1.86, 95% CI [-4.58, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.19, 95% CI [-13.90, 34.28], t(2038) = 0.83, p = 0.407; Std. beta = 0.83,
## 95% CI [-0.60, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-21.57, 24.62], t(2038) = 0.13, p = 0.897; Std. beta = -0.28,
## 95% CI [-1.78, 1.21])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.56, 95% CI [-30.55, 7.42], t(2038) = -1.19, p = 0.232; Std. beta = -0.73,
## 95% CI [-2.07, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.13, 95% CI [-6.59, 40.85], t(2038) = 1.42, p = 0.157; Std. beta = 0.83,
## 95% CI [-0.67, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.50, 95% CI [0.72, 20.27], t(2038) = 2.11, p = 0.035; Std. beta = 0.35, 95%
## CI [-0.24, 0.94])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.00, 95% CI [-4.42, 42.42], t(2038) = 1.59, p = 0.112; Std. beta = 0.66,
## 95% CI [-0.80, 2.12])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-7.80, 7.77], t(2038) = -4.16e-03, p = 0.997; Std. beta =
## 0.02, 95% CI [-0.46, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.02, 95% CI [-6.63, 20.67], t(2038) = 1.01, p = 0.313; Std. beta = 0.30, 95%
## CI [-0.53, 1.13])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.73, 2.87], t(2038) = -1.28, p = 0.199; Std. beta = -0.04,
## 95% CI [-0.56, 0.48])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-24.42, 4.05], t(2038) = -1.40, p = 0.161; Std. beta = 0.07,
## 95% CI [-0.89, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-6.64, 9.03], t(2038) = 0.30, p = 0.765; Std. beta = 0.13, 95%
## CI [-0.35, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-15.64, 2.49], t(2038) = -1.42, p = 0.155; Std. beta = -0.13,
## 95% CI [-0.69, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2038) = -0.67, p = 0.500; Std. beta = 0.26,
## 95% CI [-1.31, 1.83])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.34, 95% CI [-24.17, 15.48], t(2038) = -0.43, p = 0.667; Std. beta = 0.42,
## 95% CI [-0.77, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.02, 95% CI [-21.92, 47.96], t(2038) = 0.73, p = 0.465; Std. beta = 0.76,
## 95% CI [-1.29, 2.81])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 16.77, 95% CI [-0.23, 33.77], t(2038) = 1.93, p = 0.053; Std. beta = 1.35,
## 95% CI [0.31, 2.39])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.40, 95% CI [-13.86, 32.66], t(2038) = 0.79, p = 0.428; Std. beta = 0.57,
## 95% CI [-0.88, 2.02])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.10, 95% CI [-4.67, 30.86], t(2038) = 1.45, p = 0.148; Std. beta = 0.70,
## 95% CI [-0.38, 1.78])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.20, 95% CI [-25.43, 33.82], t(2038) = 0.28, p = 0.781; Std. beta = 0.58,
## 95% CI [-1.89, 3.06])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.56, 95% CI [-62.59, 3.48], t(2038) = -1.75, p = 0.080; Std. beta = -1.92,
## 95% CI [-4.24, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.99, 95% CI [-30.69, -1.28], t(2038) = -2.13, p = 0.033; Std. beta = -0.68,
## 95% CI [-1.60, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-29.80, 36.45], t(2038) = 0.20, p = 0.844; Std. beta = 0.19,
## 95% CI [-1.75, 2.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-27.10, 20.72], t(2038) = -0.26, p = 0.794; Std. beta = 0.47,
## 95% CI [-1.60, 2.53])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-9.70, 20.33], t(2038) = 0.69, p = 0.487; Std. beta = 0.35, 95%
## CI [-0.61, 1.30])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.36, 95% CI [-12.60, 15.32], t(2038) = 0.19, p = 0.849; Std. beta = 0.23,
## 95% CI [-0.67, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-31.28, 33.37], t(2038) = 0.06, p = 0.950; Std. beta = 0.52,
## 95% CI [-1.40, 2.44])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.38, 9.96], t(2038) = -0.13, p = 0.896; Std. beta = -0.28,
## 95% CI [-0.97, 0.41])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.62, 95% CI [-29.09, 1.84], t(2038) = -1.73, p = 0.084; Std. beta = -0.58,
## 95% CI [-1.72, 0.56])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.11, 16.66], t(2038) = 0.57, p = 0.565; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -1.68, 95% CI [-16.04, 12.69], t(2038) = -0.23, p = 0.819; Std. beta = -0.54,
## 95% CI [-1.43, 0.34])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.28, 95% CI [-18.85, 19.40], t(2038) = 0.03, p = 0.977; Std. beta = -0.90,
## 95% CI [-2.89, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-39.48, 26.22], t(2038) = -0.40, p = 0.692; Std. beta = -0.36,
## 95% CI [-2.28, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-14.16, 16.22], t(2038) = 0.13, p = 0.894; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.79, 95% CI [-9.71, 25.29], t(2038) = 0.87, p = 0.383; Std. beta = 0.23, 95%
## CI [-0.86, 1.32])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.52, 95% CI [-35.37, -1.68], t(2038) = -2.16, p = 0.031; Std. beta = -0.75,
## 95% CI [-1.85, 0.36])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-13.24, 12.82], t(2038) = -0.03, p = 0.975; Std. beta = 0.02,
## 95% CI [-0.78, 0.83])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.83, 21.87], t(2038) = 0.20, p = 0.842; Std. beta = 1.22,
## 95% CI [-0.02, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.36, 95% CI [-28.12, 1.40], t(2038) = -1.77, p = 0.076; Std. beta = -0.48,
## 95% CI [-1.41, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.40, 95% CI [-5.00, 27.80], t(2038) = 1.36, p = 0.173; Std. beta = 0.51,
## 95% CI [-0.47, 1.50])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-2.04, 21.44], t(2038) = 1.62, p = 0.105; Std. beta = 0.40, 95%
## CI [-0.32, 1.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.20, 95% CI [-17.73, 48.12], t(2038) = 0.91, p = 0.365; Std. beta = -2.89,
## 95% CI [-5.02, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.43, 95% CI [3.23, 49.63], t(2038) = 2.23, p = 0.026; Std. beta = 1.63, 95%
## CI [0.16, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.98, 95% CI [-23.42, 15.47], t(2038) = -0.40, p = 0.688; Std. beta = -0.05,
## 95% CI [-1.36, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-12.73, 8.33], t(2038) = -0.41, p = 0.682; Std. beta = 0.02,
## 95% CI [-0.91, 0.96])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.93, 95% CI [-0.89, 2.76], t(2038) = 1.00, p = 0.316;
## Std. beta = 0.06, 95% CI [-0.05, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.72, 95% CI [-42.76, 15.32], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.28, 95% CI [-3.99, 1.43])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-7.28, 12.85], t(2038) = 0.54, p = 0.588; Std.
## beta = 0.26, 95% CI [-0.68, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.43, 95% CI [-15.29, 6.43], t(2038) = -0.80, p = 0.424; Std.
## beta = -0.41, 95% CI [-1.43, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-12.81, 11.58], t(2038) = -0.10, p = 0.921;
## Std. beta = -0.06, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-11.61, 7.48], t(2038) = -0.42, p = 0.672; Std.
## beta = -0.19, 95% CI [-1.08, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.10, 95% CI [-6.17, -0.03], t(2038) = -1.98, p = 0.048; Std.
## beta = -0.29, 95% CI [-0.58, -3.11e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.43, 95% CI [-13.87, 3.02], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.51, 95% CI [-1.29, 0.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-2.53, 3.11], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.03, 95% CI [-0.24, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.32, 95% CI [-6.00, 3.36], t(2038) = -0.55, p = 0.581; Std.
## beta = -0.12, 95% CI [-0.56, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.34, 95% CI [0.09, 6.59], t(2038) = 2.02, p = 0.044; Std.
## beta = 0.31, 95% CI [8.45e-03, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.94, 95% CI [0.62, 15.26], t(2038) = 2.13, p = 0.033; Std.
## beta = 0.74, 95% CI [0.06, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-2.12, 3.58], t(2038) = 0.50, p = 0.616; Std.
## beta = 0.07, 95% CI [-0.20, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.51, 6.57], t(2038) = 1.68, p = 0.093; Std.
## beta = 0.28, 95% CI [-0.05, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.77, 95% CI [-4.53, 22.07], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.82, 95% CI [-0.42, 2.06])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.05, 95% CI [1.48, 14.62], t(2038) = 2.40, p = 0.016; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-1.46, 10.20], t(2038) = 1.47, p = 0.142; Std.
## beta = 0.41, 95% CI [-0.14, 0.95])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-7.79, 8.23], t(2038) = 0.05, p = 0.957; Std.
## beta = 0.02, 95% CI [-0.73, 0.77])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-8.89, 7.26], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.08, 95% CI [-0.83, 0.68])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.21, 41.23], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-24.55, 20.14], t(2038) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.29, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-2.22, 8.30], t(2038) = 1.13, p = 0.258; Std.
## beta = 0.28, 95% CI [-0.21, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.78, 95% CI [-13.49, 29.05], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.73, 95% CI [-1.26, 2.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.14, 6.94], t(2038) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.57, 0.65])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-4.62, 8.20], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-3.52, 14.41], t(2038) = 1.19, p = 0.234; Std.
## beta = 0.51, 95% CI [-0.33, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.16, 2.53], t(2038) = -1.03, p = 0.302; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.58, 95% CI [-7.45, 12.61], t(2038) = 0.50, p = 0.614; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.92, 5.61], t(2038) = 0.35, p = 0.727; Std.
## beta = 0.08, 95% CI [-0.37, 0.52])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.27, 95% CI [-10.99, 0.44], t(2038) = -1.81, p = 0.071; Std.
## beta = -0.49, 95% CI [-1.02, 0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-32.49, 10.64], t(2038) = -0.99, p = 0.321;
## Std. beta = -1.02, 95% CI [-3.03, 0.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-8.96, 9.75], t(2038) = 0.08, p = 0.934; Std.
## beta = 0.04, 95% CI [-0.84, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.47, 6.01], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.16, 95% CI [-0.23, 0.56])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-9.54, 4.20], t(2038) = -0.76, p = 0.446; Std.
## beta = -0.25, 95% CI [-0.89, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-3.63, 11.73], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.38, 95% CI [-0.34, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-4.46, 5.26], t(2038) = 0.16, p = 0.872; Std.
## beta = 0.04, 95% CI [-0.42, 0.49])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.06, 95% CI [4.60, 21.51], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.22, 95% CI [0.43, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.58, 95% CI [-1.94, 9.10], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.22, 3.57], t(2038) = -0.66, p = 0.507; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-6.12, 2.00], t(2038) = -1.00, p = 0.319; Std.
## beta = -0.19, 95% CI [-0.57, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.97, 95% CI [-61.85, -28.08], t(2038) = -5.22, p < .001;
## Std. beta = -4.19, 95% CI [-5.77, -2.62])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.00, 95% CI [-7.86, 9.87], t(2038) = 0.22, p = 0.825; Std.
## beta = 0.09, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.22, 95% CI [-8.78, 13.21], t(2038) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.81, 12.46], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.17, 95% CI [-0.82, 1.16])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NH4_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to NH4_5yrPreDx = 0, is at 64.64 (95% CI [57.05, 72.24], t(2038)
## = 16.69, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.79, 95% CI [-8.99, -2.59], t(2038) = -3.55, p < .001; Std. beta = -0.45, 95%
## CI [-0.59, -0.31])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -3.31, 95% CI [-7.87, 1.24], t(2038) = -1.43, p = 0.154; Std. beta =
## -0.08, 95% CI [-0.26, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.09, 95% CI [-45.50, 21.31], t(2038) = -0.71, p = 0.478; Std. beta =
## -1.86, 95% CI [-4.58, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.19, 95% CI [-13.90, 34.28], t(2038) = 0.83, p = 0.407; Std. beta = 0.83,
## 95% CI [-0.60, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-21.57, 24.62], t(2038) = 0.13, p = 0.897; Std. beta = -0.28,
## 95% CI [-1.78, 1.21])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.56, 95% CI [-30.55, 7.42], t(2038) = -1.19, p = 0.232; Std. beta = -0.73,
## 95% CI [-2.07, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.13, 95% CI [-6.59, 40.85], t(2038) = 1.42, p = 0.157; Std. beta = 0.83,
## 95% CI [-0.67, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.50, 95% CI [0.72, 20.27], t(2038) = 2.11, p = 0.035; Std. beta = 0.35, 95%
## CI [-0.24, 0.94])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.00, 95% CI [-4.42, 42.42], t(2038) = 1.59, p = 0.112; Std. beta = 0.66,
## 95% CI [-0.80, 2.12])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-7.80, 7.77], t(2038) = -4.16e-03, p = 0.997; Std. beta =
## 0.02, 95% CI [-0.46, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.02, 95% CI [-6.63, 20.67], t(2038) = 1.01, p = 0.313; Std. beta = 0.30, 95%
## CI [-0.53, 1.13])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.73, 2.87], t(2038) = -1.28, p = 0.199; Std. beta = -0.04,
## 95% CI [-0.56, 0.48])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-24.42, 4.05], t(2038) = -1.40, p = 0.161; Std. beta = 0.07,
## 95% CI [-0.89, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-6.64, 9.03], t(2038) = 0.30, p = 0.765; Std. beta = 0.13, 95%
## CI [-0.35, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-15.64, 2.49], t(2038) = -1.42, p = 0.155; Std. beta = -0.13,
## 95% CI [-0.69, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2038) = -0.67, p = 0.500; Std. beta = 0.26,
## 95% CI [-1.31, 1.83])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.34, 95% CI [-24.17, 15.48], t(2038) = -0.43, p = 0.667; Std. beta = 0.42,
## 95% CI [-0.77, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.02, 95% CI [-21.92, 47.96], t(2038) = 0.73, p = 0.465; Std. beta = 0.76,
## 95% CI [-1.29, 2.81])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 16.77, 95% CI [-0.23, 33.77], t(2038) = 1.93, p = 0.053; Std. beta = 1.35,
## 95% CI [0.31, 2.39])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.40, 95% CI [-13.86, 32.66], t(2038) = 0.79, p = 0.428; Std. beta = 0.57,
## 95% CI [-0.88, 2.02])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.10, 95% CI [-4.67, 30.86], t(2038) = 1.45, p = 0.148; Std. beta = 0.70,
## 95% CI [-0.38, 1.78])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.20, 95% CI [-25.43, 33.82], t(2038) = 0.28, p = 0.781; Std. beta = 0.58,
## 95% CI [-1.89, 3.06])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.56, 95% CI [-62.59, 3.48], t(2038) = -1.75, p = 0.080; Std. beta = -1.92,
## 95% CI [-4.24, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.99, 95% CI [-30.69, -1.28], t(2038) = -2.13, p = 0.033; Std. beta = -0.68,
## 95% CI [-1.60, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-29.80, 36.45], t(2038) = 0.20, p = 0.844; Std. beta = 0.19,
## 95% CI [-1.75, 2.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-27.10, 20.72], t(2038) = -0.26, p = 0.794; Std. beta = 0.47,
## 95% CI [-1.60, 2.53])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-9.70, 20.33], t(2038) = 0.69, p = 0.487; Std. beta = 0.35, 95%
## CI [-0.61, 1.30])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.36, 95% CI [-12.60, 15.32], t(2038) = 0.19, p = 0.849; Std. beta = 0.23,
## 95% CI [-0.67, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-31.28, 33.37], t(2038) = 0.06, p = 0.950; Std. beta = 0.52,
## 95% CI [-1.40, 2.44])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.38, 9.96], t(2038) = -0.13, p = 0.896; Std. beta = -0.28,
## 95% CI [-0.97, 0.41])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.62, 95% CI [-29.09, 1.84], t(2038) = -1.73, p = 0.084; Std. beta = -0.58,
## 95% CI [-1.72, 0.56])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.11, 16.66], t(2038) = 0.57, p = 0.565; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -1.68, 95% CI [-16.04, 12.69], t(2038) = -0.23, p = 0.819; Std. beta = -0.54,
## 95% CI [-1.43, 0.34])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.28, 95% CI [-18.85, 19.40], t(2038) = 0.03, p = 0.977; Std. beta = -0.90,
## 95% CI [-2.89, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-39.48, 26.22], t(2038) = -0.40, p = 0.692; Std. beta = -0.36,
## 95% CI [-2.28, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-14.16, 16.22], t(2038) = 0.13, p = 0.894; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.79, 95% CI [-9.71, 25.29], t(2038) = 0.87, p = 0.383; Std. beta = 0.23, 95%
## CI [-0.86, 1.32])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.52, 95% CI [-35.37, -1.68], t(2038) = -2.16, p = 0.031; Std. beta = -0.75,
## 95% CI [-1.85, 0.36])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-13.24, 12.82], t(2038) = -0.03, p = 0.975; Std. beta = 0.02,
## 95% CI [-0.78, 0.83])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.83, 21.87], t(2038) = 0.20, p = 0.842; Std. beta = 1.22,
## 95% CI [-0.02, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.36, 95% CI [-28.12, 1.40], t(2038) = -1.77, p = 0.076; Std. beta = -0.48,
## 95% CI [-1.41, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.40, 95% CI [-5.00, 27.80], t(2038) = 1.36, p = 0.173; Std. beta = 0.51,
## 95% CI [-0.47, 1.50])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-2.04, 21.44], t(2038) = 1.62, p = 0.105; Std. beta = 0.40, 95%
## CI [-0.32, 1.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.20, 95% CI [-17.73, 48.12], t(2038) = 0.91, p = 0.365; Std. beta = -2.89,
## 95% CI [-5.02, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.43, 95% CI [3.23, 49.63], t(2038) = 2.23, p = 0.026; Std. beta = 1.63, 95%
## CI [0.16, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.98, 95% CI [-23.42, 15.47], t(2038) = -0.40, p = 0.688; Std. beta = -0.05,
## 95% CI [-1.36, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-12.73, 8.33], t(2038) = -0.41, p = 0.682; Std. beta = 0.02,
## 95% CI [-0.91, 0.96])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.93, 95% CI [-0.89, 2.76], t(2038) = 1.00, p = 0.316;
## Std. beta = 0.06, 95% CI [-0.05, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.72, 95% CI [-42.76, 15.32], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.28, 95% CI [-3.99, 1.43])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-7.28, 12.85], t(2038) = 0.54, p = 0.588; Std.
## beta = 0.26, 95% CI [-0.68, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.43, 95% CI [-15.29, 6.43], t(2038) = -0.80, p = 0.424; Std.
## beta = -0.41, 95% CI [-1.43, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-12.81, 11.58], t(2038) = -0.10, p = 0.921;
## Std. beta = -0.06, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-11.61, 7.48], t(2038) = -0.42, p = 0.672; Std.
## beta = -0.19, 95% CI [-1.08, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.10, 95% CI [-6.17, -0.03], t(2038) = -1.98, p = 0.048; Std.
## beta = -0.29, 95% CI [-0.58, -3.11e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.43, 95% CI [-13.87, 3.02], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.51, 95% CI [-1.29, 0.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-2.53, 3.11], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.03, 95% CI [-0.24, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.32, 95% CI [-6.00, 3.36], t(2038) = -0.55, p = 0.581; Std.
## beta = -0.12, 95% CI [-0.56, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.34, 95% CI [0.09, 6.59], t(2038) = 2.02, p = 0.044; Std.
## beta = 0.31, 95% CI [8.45e-03, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.94, 95% CI [0.62, 15.26], t(2038) = 2.13, p = 0.033; Std.
## beta = 0.74, 95% CI [0.06, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-2.12, 3.58], t(2038) = 0.50, p = 0.616; Std.
## beta = 0.07, 95% CI [-0.20, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.51, 6.57], t(2038) = 1.68, p = 0.093; Std.
## beta = 0.28, 95% CI [-0.05, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.77, 95% CI [-4.53, 22.07], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.82, 95% CI [-0.42, 2.06])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.05, 95% CI [1.48, 14.62], t(2038) = 2.40, p = 0.016; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-1.46, 10.20], t(2038) = 1.47, p = 0.142; Std.
## beta = 0.41, 95% CI [-0.14, 0.95])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-7.79, 8.23], t(2038) = 0.05, p = 0.957; Std.
## beta = 0.02, 95% CI [-0.73, 0.77])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-8.89, 7.26], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.08, 95% CI [-0.83, 0.68])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.21, 41.23], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-24.55, 20.14], t(2038) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.29, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-2.22, 8.30], t(2038) = 1.13, p = 0.258; Std.
## beta = 0.28, 95% CI [-0.21, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.78, 95% CI [-13.49, 29.05], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.73, 95% CI [-1.26, 2.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.14, 6.94], t(2038) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.57, 0.65])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-4.62, 8.20], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-3.52, 14.41], t(2038) = 1.19, p = 0.234; Std.
## beta = 0.51, 95% CI [-0.33, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.16, 2.53], t(2038) = -1.03, p = 0.302; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.58, 95% CI [-7.45, 12.61], t(2038) = 0.50, p = 0.614; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.92, 5.61], t(2038) = 0.35, p = 0.727; Std.
## beta = 0.08, 95% CI [-0.37, 0.52])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.27, 95% CI [-10.99, 0.44], t(2038) = -1.81, p = 0.071; Std.
## beta = -0.49, 95% CI [-1.02, 0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-32.49, 10.64], t(2038) = -0.99, p = 0.321;
## Std. beta = -1.02, 95% CI [-3.03, 0.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-8.96, 9.75], t(2038) = 0.08, p = 0.934; Std.
## beta = 0.04, 95% CI [-0.84, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.47, 6.01], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.16, 95% CI [-0.23, 0.56])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-9.54, 4.20], t(2038) = -0.76, p = 0.446; Std.
## beta = -0.25, 95% CI [-0.89, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-3.63, 11.73], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.38, 95% CI [-0.34, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-4.46, 5.26], t(2038) = 0.16, p = 0.872; Std.
## beta = 0.04, 95% CI [-0.42, 0.49])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.06, 95% CI [4.60, 21.51], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.22, 95% CI [0.43, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.58, 95% CI [-1.94, 9.10], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.22, 3.57], t(2038) = -0.66, p = 0.507; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-6.12, 2.00], t(2038) = -1.00, p = 0.319; Std.
## beta = -0.19, 95% CI [-0.57, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.97, 95% CI [-61.85, -28.08], t(2038) = -5.22, p < .001;
## Std. beta = -4.19, 95% CI [-5.77, -2.62])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.00, 95% CI [-7.86, 9.87], t(2038) = 0.22, p = 0.825; Std.
## beta = 0.09, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.22, 95% CI [-8.78, 13.21], t(2038) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.81, 12.46], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.17, 95% CI [-0.82, 1.16])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 64.64 (95% CI [57.05, 72.24], t(2038) = 16.69, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.79, 95% CI [-8.99, -2.59], t(2038) = -3.55, p < .001; Std. beta = -0.45, 95%
## CI [-0.59, -0.31])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -3.31, 95% CI [-7.87, 1.24], t(2038) = -1.43, p = 0.154; Std. beta =
## -0.08, 95% CI [-0.26, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.09, 95% CI [-45.50, 21.31], t(2038) = -0.71, p = 0.478; Std. beta =
## -1.86, 95% CI [-4.58, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.19, 95% CI [-13.90, 34.28], t(2038) = 0.83, p = 0.407; Std. beta = 0.83,
## 95% CI [-0.60, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-21.57, 24.62], t(2038) = 0.13, p = 0.897; Std. beta = -0.28,
## 95% CI [-1.78, 1.21])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.56, 95% CI [-30.55, 7.42], t(2038) = -1.19, p = 0.232; Std. beta = -0.73,
## 95% CI [-2.07, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.13, 95% CI [-6.59, 40.85], t(2038) = 1.42, p = 0.157; Std. beta = 0.83,
## 95% CI [-0.67, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.50, 95% CI [0.72, 20.27], t(2038) = 2.11, p = 0.035; Std. beta = 0.35, 95%
## CI [-0.24, 0.94])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.00, 95% CI [-4.42, 42.42], t(2038) = 1.59, p = 0.112; Std. beta = 0.66,
## 95% CI [-0.80, 2.12])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-7.80, 7.77], t(2038) = -4.16e-03, p = 0.997; Std. beta =
## 0.02, 95% CI [-0.46, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.02, 95% CI [-6.63, 20.67], t(2038) = 1.01, p = 0.313; Std. beta = 0.30, 95%
## CI [-0.53, 1.13])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.73, 2.87], t(2038) = -1.28, p = 0.199; Std. beta = -0.04,
## 95% CI [-0.56, 0.48])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-24.42, 4.05], t(2038) = -1.40, p = 0.161; Std. beta = 0.07,
## 95% CI [-0.89, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-6.64, 9.03], t(2038) = 0.30, p = 0.765; Std. beta = 0.13, 95%
## CI [-0.35, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-15.64, 2.49], t(2038) = -1.42, p = 0.155; Std. beta = -0.13,
## 95% CI [-0.69, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2038) = -0.67, p = 0.500; Std. beta = 0.26,
## 95% CI [-1.31, 1.83])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.34, 95% CI [-24.17, 15.48], t(2038) = -0.43, p = 0.667; Std. beta = 0.42,
## 95% CI [-0.77, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.02, 95% CI [-21.92, 47.96], t(2038) = 0.73, p = 0.465; Std. beta = 0.76,
## 95% CI [-1.29, 2.81])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 16.77, 95% CI [-0.23, 33.77], t(2038) = 1.93, p = 0.053; Std. beta = 1.35,
## 95% CI [0.31, 2.39])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.40, 95% CI [-13.86, 32.66], t(2038) = 0.79, p = 0.428; Std. beta = 0.57,
## 95% CI [-0.88, 2.02])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.10, 95% CI [-4.67, 30.86], t(2038) = 1.45, p = 0.148; Std. beta = 0.70,
## 95% CI [-0.38, 1.78])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.20, 95% CI [-25.43, 33.82], t(2038) = 0.28, p = 0.781; Std. beta = 0.58,
## 95% CI [-1.89, 3.06])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.56, 95% CI [-62.59, 3.48], t(2038) = -1.75, p = 0.080; Std. beta = -1.92,
## 95% CI [-4.24, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.99, 95% CI [-30.69, -1.28], t(2038) = -2.13, p = 0.033; Std. beta = -0.68,
## 95% CI [-1.60, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-29.80, 36.45], t(2038) = 0.20, p = 0.844; Std. beta = 0.19,
## 95% CI [-1.75, 2.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-27.10, 20.72], t(2038) = -0.26, p = 0.794; Std. beta = 0.47,
## 95% CI [-1.60, 2.53])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-9.70, 20.33], t(2038) = 0.69, p = 0.487; Std. beta = 0.35, 95%
## CI [-0.61, 1.30])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.36, 95% CI [-12.60, 15.32], t(2038) = 0.19, p = 0.849; Std. beta = 0.23,
## 95% CI [-0.67, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-31.28, 33.37], t(2038) = 0.06, p = 0.950; Std. beta = 0.52,
## 95% CI [-1.40, 2.44])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.38, 9.96], t(2038) = -0.13, p = 0.896; Std. beta = -0.28,
## 95% CI [-0.97, 0.41])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.62, 95% CI [-29.09, 1.84], t(2038) = -1.73, p = 0.084; Std. beta = -0.58,
## 95% CI [-1.72, 0.56])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.11, 16.66], t(2038) = 0.57, p = 0.565; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -1.68, 95% CI [-16.04, 12.69], t(2038) = -0.23, p = 0.819; Std. beta = -0.54,
## 95% CI [-1.43, 0.34])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.28, 95% CI [-18.85, 19.40], t(2038) = 0.03, p = 0.977; Std. beta = -0.90,
## 95% CI [-2.89, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-39.48, 26.22], t(2038) = -0.40, p = 0.692; Std. beta = -0.36,
## 95% CI [-2.28, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-14.16, 16.22], t(2038) = 0.13, p = 0.894; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.79, 95% CI [-9.71, 25.29], t(2038) = 0.87, p = 0.383; Std. beta = 0.23, 95%
## CI [-0.86, 1.32])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.52, 95% CI [-35.37, -1.68], t(2038) = -2.16, p = 0.031; Std. beta = -0.75,
## 95% CI [-1.85, 0.36])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-13.24, 12.82], t(2038) = -0.03, p = 0.975; Std. beta = 0.02,
## 95% CI [-0.78, 0.83])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.83, 21.87], t(2038) = 0.20, p = 0.842; Std. beta = 1.22,
## 95% CI [-0.02, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.36, 95% CI [-28.12, 1.40], t(2038) = -1.77, p = 0.076; Std. beta = -0.48,
## 95% CI [-1.41, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.40, 95% CI [-5.00, 27.80], t(2038) = 1.36, p = 0.173; Std. beta = 0.51,
## 95% CI [-0.47, 1.50])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-2.04, 21.44], t(2038) = 1.62, p = 0.105; Std. beta = 0.40, 95%
## CI [-0.32, 1.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.20, 95% CI [-17.73, 48.12], t(2038) = 0.91, p = 0.365; Std. beta = -2.89,
## 95% CI [-5.02, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.43, 95% CI [3.23, 49.63], t(2038) = 2.23, p = 0.026; Std. beta = 1.63, 95%
## CI [0.16, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.98, 95% CI [-23.42, 15.47], t(2038) = -0.40, p = 0.688; Std. beta = -0.05,
## 95% CI [-1.36, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-12.73, 8.33], t(2038) = -0.41, p = 0.682; Std. beta = 0.02,
## 95% CI [-0.91, 0.96])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.93, 95% CI [-0.89, 2.76], t(2038) = 1.00, p = 0.316;
## Std. beta = 0.06, 95% CI [-0.05, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.72, 95% CI [-42.76, 15.32], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.28, 95% CI [-3.99, 1.43])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-7.28, 12.85], t(2038) = 0.54, p = 0.588; Std.
## beta = 0.26, 95% CI [-0.68, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.43, 95% CI [-15.29, 6.43], t(2038) = -0.80, p = 0.424; Std.
## beta = -0.41, 95% CI [-1.43, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-12.81, 11.58], t(2038) = -0.10, p = 0.921;
## Std. beta = -0.06, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-11.61, 7.48], t(2038) = -0.42, p = 0.672; Std.
## beta = -0.19, 95% CI [-1.08, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.10, 95% CI [-6.17, -0.03], t(2038) = -1.98, p = 0.048; Std.
## beta = -0.29, 95% CI [-0.58, -3.11e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.43, 95% CI [-13.87, 3.02], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.51, 95% CI [-1.29, 0.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-2.53, 3.11], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.03, 95% CI [-0.24, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.32, 95% CI [-6.00, 3.36], t(2038) = -0.55, p = 0.581; Std.
## beta = -0.12, 95% CI [-0.56, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.34, 95% CI [0.09, 6.59], t(2038) = 2.02, p = 0.044; Std.
## beta = 0.31, 95% CI [8.45e-03, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.94, 95% CI [0.62, 15.26], t(2038) = 2.13, p = 0.033; Std.
## beta = 0.74, 95% CI [0.06, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-2.12, 3.58], t(2038) = 0.50, p = 0.616; Std.
## beta = 0.07, 95% CI [-0.20, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.51, 6.57], t(2038) = 1.68, p = 0.093; Std.
## beta = 0.28, 95% CI [-0.05, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.77, 95% CI [-4.53, 22.07], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.82, 95% CI [-0.42, 2.06])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.05, 95% CI [1.48, 14.62], t(2038) = 2.40, p = 0.016; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-1.46, 10.20], t(2038) = 1.47, p = 0.142; Std.
## beta = 0.41, 95% CI [-0.14, 0.95])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-7.79, 8.23], t(2038) = 0.05, p = 0.957; Std.
## beta = 0.02, 95% CI [-0.73, 0.77])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-8.89, 7.26], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.08, 95% CI [-0.83, 0.68])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.21, 41.23], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-24.55, 20.14], t(2038) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.29, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-2.22, 8.30], t(2038) = 1.13, p = 0.258; Std.
## beta = 0.28, 95% CI [-0.21, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.78, 95% CI [-13.49, 29.05], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.73, 95% CI [-1.26, 2.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.14, 6.94], t(2038) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.57, 0.65])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-4.62, 8.20], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-3.52, 14.41], t(2038) = 1.19, p = 0.234; Std.
## beta = 0.51, 95% CI [-0.33, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.16, 2.53], t(2038) = -1.03, p = 0.302; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.58, 95% CI [-7.45, 12.61], t(2038) = 0.50, p = 0.614; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.92, 5.61], t(2038) = 0.35, p = 0.727; Std.
## beta = 0.08, 95% CI [-0.37, 0.52])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.27, 95% CI [-10.99, 0.44], t(2038) = -1.81, p = 0.071; Std.
## beta = -0.49, 95% CI [-1.02, 0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-32.49, 10.64], t(2038) = -0.99, p = 0.321;
## Std. beta = -1.02, 95% CI [-3.03, 0.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-8.96, 9.75], t(2038) = 0.08, p = 0.934; Std.
## beta = 0.04, 95% CI [-0.84, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.47, 6.01], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.16, 95% CI [-0.23, 0.56])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-9.54, 4.20], t(2038) = -0.76, p = 0.446; Std.
## beta = -0.25, 95% CI [-0.89, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-3.63, 11.73], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.38, 95% CI [-0.34, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-4.46, 5.26], t(2038) = 0.16, p = 0.872; Std.
## beta = 0.04, 95% CI [-0.42, 0.49])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.06, 95% CI [4.60, 21.51], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.22, 95% CI [0.43, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.58, 95% CI [-1.94, 9.10], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.22, 3.57], t(2038) = -0.66, p = 0.507; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-6.12, 2.00], t(2038) = -1.00, p = 0.319; Std.
## beta = -0.19, 95% CI [-0.57, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.97, 95% CI [-61.85, -28.08], t(2038) = -5.22, p < .001;
## Std. beta = -4.19, 95% CI [-5.77, -2.62])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.00, 95% CI [-7.86, 9.87], t(2038) = 0.22, p = 0.825; Std.
## beta = 0.09, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.22, 95% CI [-8.78, 13.21], t(2038) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.81, 12.46], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.17, 95% CI [-0.82, 1.16])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to cohort = CARE-PF, is at 64.64 (95% CI [57.05, 72.24], t(2038)
## = 16.69, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.79, 95% CI [-8.99, -2.59], t(2038) = -3.55, p < .001; Std. beta = -0.45, 95%
## CI [-0.59, -0.31])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -3.31, 95% CI [-7.87, 1.24], t(2038) = -1.43, p = 0.154; Std. beta =
## -0.08, 95% CI [-0.26, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.09, 95% CI [-45.50, 21.31], t(2038) = -0.71, p = 0.478; Std. beta =
## -1.86, 95% CI [-4.58, 0.86])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.19, 95% CI [-13.90, 34.28], t(2038) = 0.83, p = 0.407; Std. beta = 0.83,
## 95% CI [-0.60, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-21.57, 24.62], t(2038) = 0.13, p = 0.897; Std. beta = -0.28,
## 95% CI [-1.78, 1.21])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.56, 95% CI [-30.55, 7.42], t(2038) = -1.19, p = 0.232; Std. beta = -0.73,
## 95% CI [-2.07, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 17.13, 95% CI [-6.59, 40.85], t(2038) = 1.42, p = 0.157; Std. beta = 0.83,
## 95% CI [-0.67, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.50, 95% CI [0.72, 20.27], t(2038) = 2.11, p = 0.035; Std. beta = 0.35, 95%
## CI [-0.24, 0.94])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.00, 95% CI [-4.42, 42.42], t(2038) = 1.59, p = 0.112; Std. beta = 0.66,
## 95% CI [-0.80, 2.12])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-7.80, 7.77], t(2038) = -4.16e-03, p = 0.997; Std. beta =
## 0.02, 95% CI [-0.46, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.02, 95% CI [-6.63, 20.67], t(2038) = 1.01, p = 0.313; Std. beta = 0.30, 95%
## CI [-0.53, 1.13])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.73, 2.87], t(2038) = -1.28, p = 0.199; Std. beta = -0.04,
## 95% CI [-0.56, 0.48])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-24.42, 4.05], t(2038) = -1.40, p = 0.161; Std. beta = 0.07,
## 95% CI [-0.89, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.19, 95% CI [-6.64, 9.03], t(2038) = 0.30, p = 0.765; Std. beta = 0.13, 95%
## CI [-0.35, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-15.64, 2.49], t(2038) = -1.42, p = 0.155; Std. beta = -0.13,
## 95% CI [-0.69, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2038) = -0.67, p = 0.500; Std. beta = 0.26,
## 95% CI [-1.31, 1.83])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.34, 95% CI [-24.17, 15.48], t(2038) = -0.43, p = 0.667; Std. beta = 0.42,
## 95% CI [-0.77, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.02, 95% CI [-21.92, 47.96], t(2038) = 0.73, p = 0.465; Std. beta = 0.76,
## 95% CI [-1.29, 2.81])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 16.77, 95% CI [-0.23, 33.77], t(2038) = 1.93, p = 0.053; Std. beta = 1.35,
## 95% CI [0.31, 2.39])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.40, 95% CI [-13.86, 32.66], t(2038) = 0.79, p = 0.428; Std. beta = 0.57,
## 95% CI [-0.88, 2.02])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 13.10, 95% CI [-4.67, 30.86], t(2038) = 1.45, p = 0.148; Std. beta = 0.70,
## 95% CI [-0.38, 1.78])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.20, 95% CI [-25.43, 33.82], t(2038) = 0.28, p = 0.781; Std. beta = 0.58,
## 95% CI [-1.89, 3.06])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -29.56, 95% CI [-62.59, 3.48], t(2038) = -1.75, p = 0.080; Std. beta = -1.92,
## 95% CI [-4.24, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.99, 95% CI [-30.69, -1.28], t(2038) = -2.13, p = 0.033; Std. beta = -0.68,
## 95% CI [-1.60, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-29.80, 36.45], t(2038) = 0.20, p = 0.844; Std. beta = 0.19,
## 95% CI [-1.75, 2.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-27.10, 20.72], t(2038) = -0.26, p = 0.794; Std. beta = 0.47,
## 95% CI [-1.60, 2.53])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-9.70, 20.33], t(2038) = 0.69, p = 0.487; Std. beta = 0.35, 95%
## CI [-0.61, 1.30])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.36, 95% CI [-12.60, 15.32], t(2038) = 0.19, p = 0.849; Std. beta = 0.23,
## 95% CI [-0.67, 1.13])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-31.28, 33.37], t(2038) = 0.06, p = 0.950; Std. beta = 0.52,
## 95% CI [-1.40, 2.44])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.38, 9.96], t(2038) = -0.13, p = 0.896; Std. beta = -0.28,
## 95% CI [-0.97, 0.41])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.62, 95% CI [-29.09, 1.84], t(2038) = -1.73, p = 0.084; Std. beta = -0.58,
## 95% CI [-1.72, 0.56])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.11, 16.66], t(2038) = 0.57, p = 0.565; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -1.68, 95% CI [-16.04, 12.69], t(2038) = -0.23, p = 0.819; Std. beta = -0.54,
## 95% CI [-1.43, 0.34])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.28, 95% CI [-18.85, 19.40], t(2038) = 0.03, p = 0.977; Std. beta = -0.90,
## 95% CI [-2.89, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-39.48, 26.22], t(2038) = -0.40, p = 0.692; Std. beta = -0.36,
## 95% CI [-2.28, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-14.16, 16.22], t(2038) = 0.13, p = 0.894; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.79, 95% CI [-9.71, 25.29], t(2038) = 0.87, p = 0.383; Std. beta = 0.23, 95%
## CI [-0.86, 1.32])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.52, 95% CI [-35.37, -1.68], t(2038) = -2.16, p = 0.031; Std. beta = -0.75,
## 95% CI [-1.85, 0.36])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-13.24, 12.82], t(2038) = -0.03, p = 0.975; Std. beta = 0.02,
## 95% CI [-0.78, 0.83])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-17.83, 21.87], t(2038) = 0.20, p = 0.842; Std. beta = 1.22,
## 95% CI [-0.02, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.36, 95% CI [-28.12, 1.40], t(2038) = -1.77, p = 0.076; Std. beta = -0.48,
## 95% CI [-1.41, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.40, 95% CI [-5.00, 27.80], t(2038) = 1.36, p = 0.173; Std. beta = 0.51,
## 95% CI [-0.47, 1.50])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-2.04, 21.44], t(2038) = 1.62, p = 0.105; Std. beta = 0.40, 95%
## CI [-0.32, 1.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.20, 95% CI [-17.73, 48.12], t(2038) = 0.91, p = 0.365; Std. beta = -2.89,
## 95% CI [-5.02, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.43, 95% CI [3.23, 49.63], t(2038) = 2.23, p = 0.026; Std. beta = 1.63, 95%
## CI [0.16, 3.11])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.98, 95% CI [-23.42, 15.47], t(2038) = -0.40, p = 0.688; Std. beta = -0.05,
## 95% CI [-1.36, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-12.73, 8.33], t(2038) = -0.41, p = 0.682; Std. beta = 0.02,
## 95% CI [-0.91, 0.96])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.93, 95% CI [-0.89, 2.76], t(2038) = 1.00, p = 0.316;
## Std. beta = 0.06, 95% CI [-0.05, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.72, 95% CI [-42.76, 15.32], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.28, 95% CI [-3.99, 1.43])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-7.28, 12.85], t(2038) = 0.54, p = 0.588; Std.
## beta = 0.26, 95% CI [-0.68, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.43, 95% CI [-15.29, 6.43], t(2038) = -0.80, p = 0.424; Std.
## beta = -0.41, 95% CI [-1.43, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-12.81, 11.58], t(2038) = -0.10, p = 0.921;
## Std. beta = -0.06, 95% CI [-1.19, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-11.61, 7.48], t(2038) = -0.42, p = 0.672; Std.
## beta = -0.19, 95% CI [-1.08, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.10, 95% CI [-6.17, -0.03], t(2038) = -1.98, p = 0.048; Std.
## beta = -0.29, 95% CI [-0.58, -3.11e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.43, 95% CI [-13.87, 3.02], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.51, 95% CI [-1.29, 0.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-2.53, 3.11], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.03, 95% CI [-0.24, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.32, 95% CI [-6.00, 3.36], t(2038) = -0.55, p = 0.581; Std.
## beta = -0.12, 95% CI [-0.56, 0.31])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 3.34, 95% CI [0.09, 6.59], t(2038) = 2.02, p = 0.044; Std.
## beta = 0.31, 95% CI [8.45e-03, 0.61])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.94, 95% CI [0.62, 15.26], t(2038) = 2.13, p = 0.033; Std.
## beta = 0.74, 95% CI [0.06, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-2.12, 3.58], t(2038) = 0.50, p = 0.616; Std.
## beta = 0.07, 95% CI [-0.20, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-0.51, 6.57], t(2038) = 1.68, p = 0.093; Std.
## beta = 0.28, 95% CI [-0.05, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.77, 95% CI [-4.53, 22.07], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.82, 95% CI [-0.42, 2.06])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 8.05, 95% CI [1.48, 14.62], t(2038) = 2.40, p = 0.016; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-1.46, 10.20], t(2038) = 1.47, p = 0.142; Std.
## beta = 0.41, 95% CI [-0.14, 0.95])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-7.79, 8.23], t(2038) = 0.05, p = 0.957; Std.
## beta = 0.02, 95% CI [-0.73, 0.77])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-8.89, 7.26], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.08, 95% CI [-0.83, 0.68])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.21, 41.23], t(2038) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.10, 3.84])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-24.55, 20.14], t(2038) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.29, 1.88])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-2.22, 8.30], t(2038) = 1.13, p = 0.258; Std.
## beta = 0.28, 95% CI [-0.21, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.78, 95% CI [-13.49, 29.05], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.73, 95% CI [-1.26, 2.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.14, 6.94], t(2038) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.57, 0.65])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-4.62, 8.20], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-3.52, 14.41], t(2038) = 1.19, p = 0.234; Std.
## beta = 0.51, 95% CI [-0.33, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.16, 2.53], t(2038) = -1.03, p = 0.302; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 2.58, 95% CI [-7.45, 12.61], t(2038) = 0.50, p = 0.614; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.92, 5.61], t(2038) = 0.35, p = 0.727; Std.
## beta = 0.08, 95% CI [-0.37, 0.52])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.27, 95% CI [-10.99, 0.44], t(2038) = -1.81, p = 0.071; Std.
## beta = -0.49, 95% CI [-1.02, 0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-32.49, 10.64], t(2038) = -0.99, p = 0.321;
## Std. beta = -1.02, 95% CI [-3.03, 0.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-8.96, 9.75], t(2038) = 0.08, p = 0.934; Std.
## beta = 0.04, 95% CI [-0.84, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.47, 6.01], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.16, 95% CI [-0.23, 0.56])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-9.54, 4.20], t(2038) = -0.76, p = 0.446; Std.
## beta = -0.25, 95% CI [-0.89, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-3.63, 11.73], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.38, 95% CI [-0.34, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-4.46, 5.26], t(2038) = 0.16, p = 0.872; Std.
## beta = 0.04, 95% CI [-0.42, 0.49])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.06, 95% CI [4.60, 21.51], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.22, 95% CI [0.43, 2.01])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.58, 95% CI [-1.94, 9.10], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.85])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.22, 3.57], t(2038) = -0.66, p = 0.507; Std.
## beta = -0.17, 95% CI [-0.67, 0.33])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-6.12, 2.00], t(2038) = -1.00, p = 0.319; Std.
## beta = -0.19, 95% CI [-0.57, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -44.97, 95% CI [-61.85, -28.08], t(2038) = -5.22, p < .001;
## Std. beta = -4.19, 95% CI [-5.77, -2.62])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.00, 95% CI [-7.86, 9.87], t(2038) = 0.22, p = 0.825; Std.
## beta = 0.09, 95% CI [-0.73, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.22, 95% CI [-8.78, 13.21], t(2038) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.81, 12.46], t(2038) = 0.34, p = 0.736; Std.
## beta = 0.17, 95% CI [-0.82, 1.16])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*NH4_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14183.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2721 -0.4413 -0.0120 0.4494 4.5356
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 231.77 15.224
## time_firstPFT 13.58 3.685 -0.06
## Residual 25.76 5.076
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 31.96497 7.65306 4.177
## time_firstPFT -2.73512 3.02155 -0.905
## NH4_5yrPreDx -0.08397 2.37119 -0.035
## disadv 4.05137 2.91240 1.391
## dich_RaceNon-White -7.28316 2.82094 -2.582
## sexF 3.58981 1.75731 2.043
## age_dx 0.38794 0.09227 4.204
## smokeHxFormer 3.72207 1.72775 2.154
## smokeHxAlways 18.52392 8.39658 2.206
## smokeHxUnknown -2.30579 3.93641 -0.586
## site02R -11.36295 16.44357 -0.691
## site03R 11.91899 11.96211 0.996
## site04R 2.98588 11.31255 0.264
## site05R -12.47307 9.33886 -1.336
## site06R 10.45663 16.25859 0.643
## site07R 11.51619 4.82594 2.386
## site09R 20.31946 11.53215 1.762
## site101 4.21074 3.94830 1.066
## site102 12.30115 6.88203 1.787
## site103 -1.39837 4.36205 -0.321
## site104 -7.14471 7.10069 -1.006
## site105 4.42782 3.97646 1.114
## site106 -5.58747 4.58437 -1.219
## site107 -2.27800 11.69838 -0.195
## site108 4.85436 10.26199 0.473
## site10R 13.32785 17.39756 0.766
## site11R 17.16115 8.32801 2.061
## site12R 7.15903 11.39142 0.628
## site13R 17.33687 8.82889 1.964
## site14R 5.86810 14.78387 0.397
## site15R -34.01186 16.24100 -2.094
## site16R -9.02462 7.34166 -1.229
## site17R 10.21977 16.45692 0.621
## site18R -3.47450 11.72530 -0.296
## site19R 8.78386 7.42637 1.183
## site20R 2.26253 6.89602 0.328
## site21R 2.54304 15.78542 0.161
## site22R -2.63358 5.31879 -0.495
## site23R -13.26847 9.10623 -1.457
## site24R 4.73430 6.33421 0.747
## site25R 0.54957 7.15653 0.077
## site28R 4.15185 9.43867 0.440
## site29R -6.38296 16.14899 -0.395
## site31R 5.36476 7.62345 0.704
## site32R 9.28120 8.64082 1.074
## site33R -14.24512 8.30125 -1.716
## site34R -0.03740 6.40936 -0.006
## site35R -0.57514 9.76199 -0.059
## site36R -11.43378 7.26235 -1.574
## site37R 15.55917 8.14558 1.910
## site38R 12.33086 5.80400 2.125
## site39R 23.78665 16.50225 1.441
## site40R 25.62677 11.35628 2.257
## site41R -3.17709 9.62333 -0.330
## site42R -1.03606 5.24330 -0.198
## time_firstPFT:NH4_5yrPreDx 0.61387 1.02936 0.596
## time_firstPFT:disadv -0.14974 1.11390 -0.134
## time_firstPFT:dich_RaceNon-White 0.04387 1.12570 0.039
## time_firstPFT:sexF -0.11403 0.67349 -0.169
## time_firstPFT:age_dx -0.05013 0.03526 -1.422
## time_firstPFT:smokeHxFormer 0.42566 0.67452 0.631
## time_firstPFT:smokeHxAlways 1.35510 5.31465 0.255
## time_firstPFT:smokeHxUnknown 1.35837 1.70618 0.796
## time_firstPFT:site02R -13.60134 14.86738 -0.915
## time_firstPFT:site03R 3.52870 5.24738 0.672
## time_firstPFT:site04R -4.27351 5.64070 -0.758
## time_firstPFT:site05R -0.36551 6.26828 -0.058
## time_firstPFT:site07R -2.95964 1.62852 -1.817
## time_firstPFT:site09R -5.60830 4.42563 -1.267
## time_firstPFT:site101 0.10928 1.50435 0.073
## time_firstPFT:site102 -1.83481 2.50810 -0.732
## time_firstPFT:site103 3.09091 1.82255 1.696
## time_firstPFT:site104 7.95337 3.86205 2.059
## time_firstPFT:site105 0.43843 1.53274 0.286
## time_firstPFT:site106 3.24853 1.89432 1.715
## time_firstPFT:site107 8.43694 6.84411 1.233
## time_firstPFT:site108 7.64824 3.66154 2.089
## time_firstPFT:site11R 4.74954 3.07468 1.545
## time_firstPFT:site12R 0.37541 4.19372 0.090
## time_firstPFT:site13R -0.76016 4.23312 -0.180
## time_firstPFT:site14R 4.01120 19.01917 0.211
## time_firstPFT:site15R -2.07875 11.45340 -0.181
## time_firstPFT:site16R 2.62169 2.82330 0.929
## time_firstPFT:site18R 7.86070 10.89141 0.722
## time_firstPFT:site19R 0.66384 3.41579 0.194
## time_firstPFT:site20R 2.17736 3.38407 0.643
## time_firstPFT:site21R 5.24583 4.66681 1.124
## time_firstPFT:site22R -2.26584 2.80405 -0.808
## time_firstPFT:site23R 9.95972 24.77167 0.402
## time_firstPFT:site24R 0.62998 2.48458 0.254
## time_firstPFT:site25R -5.04486 3.02967 -1.665
## time_firstPFT:site28R -9.34318 11.12471 -0.840
## time_firstPFT:site29R 0.54515 4.90727 0.111
## time_firstPFT:site31R 1.54849 2.31638 0.668
## time_firstPFT:site32R -2.48847 3.60835 -0.690
## time_firstPFT:site33R 4.20936 4.04406 1.041
## time_firstPFT:site34R 0.30957 2.55011 0.121
## time_firstPFT:site35R 13.41397 4.38860 3.057
## time_firstPFT:site36R 3.74455 2.88973 1.296
## time_firstPFT:site37R -1.38765 2.90794 -0.477
## time_firstPFT:site38R -2.13785 2.14173 -0.998
## time_firstPFT:site39R -45.57936 8.78882 -5.186
## time_firstPFT:site40R 1.64022 4.66014 0.352
## time_firstPFT:site41R 2.57334 5.66476 0.454
## time_firstPFT:site42R 2.47442 5.44106 0.455##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.917
## Unadjusted ICC: 0.690report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NH4_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 31.96 (95% CI [16.96, 46.97], t(2008)
## = 4.18, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NH4_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to NH4_5yrPreDx
## = 0, is at 31.96 (95% CI [16.96, 46.97], t(2008) = 4.18, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 31.96 (95% CI [16.96,
## 46.97], t(2008) = 4.18, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to dich_Race = White, is at 31.96 (95% CI
## [16.96, 46.97], t(2008) = 4.18, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 31.96 (95% CI [16.96,
## 46.97], t(2008) = 4.18, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 31.96 (95% CI [16.96,
## 46.97], t(2008) = 4.18, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 31.96 (95% CI
## [16.96, 46.97], t(2008) = 4.18, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 31.96 (95% CI [16.96,
## 46.97], t(2008) = 4.18, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to cohort =
## CARE-PF, is at 31.96 (95% CI [16.96, 46.97], t(2008) = 4.18, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.74, 95% CI [-8.66, 3.19], t(2008) = -0.91, p = 0.365; Std. beta =
## -0.48, 95% CI [-0.66, -0.30])
## - The effect of NH4 5yrPreDx is statistically non-significant and negative
## (beta = -0.08, 95% CI [-4.73, 4.57], t(2008) = -0.04, p = 0.972; Std. beta =
## 0.03, 95% CI [-0.17, 0.23])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.05, 95% CI [-1.66, 9.76], t(2008) = 1.39, p = 0.164; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.28, 95% CI [-12.82, -1.75], t(2008) = -2.58, p = 0.010; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.59,
## 95% CI [0.14, 7.04], t(2008) = 2.04, p = 0.041; Std. beta = 0.20, 95% CI
## [-0.02, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.20, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.72, 95% CI [0.33, 7.11], t(2008) = 2.15, p = 0.031; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.52, 95% CI [2.06, 34.99], t(2008) = 2.21, p = 0.027; Std. beta =
## 1.20, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.31, 95% CI [-10.03, 5.41], t(2008) = -0.59, p = 0.558; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-43.61, 20.89], t(2008) = -0.69, p = 0.490; Std. beta =
## -1.81, 95% CI [-4.51, 0.88])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.92, 95% CI [-11.54, 35.38], t(2008) = 1.00, p = 0.319; Std. beta = 1.00,
## 95% CI [-0.42, 2.41])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.99, 95% CI [-19.20, 25.17], t(2008) = 0.26, p = 0.792; Std. beta = -0.19,
## 95% CI [-1.65, 1.28])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-30.79, 5.84], t(2008) = -1.34, p = 0.182; Std. beta = -0.76,
## 95% CI [-2.09, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.46, 95% CI [-21.43, 42.34], t(2008) = 0.64, p = 0.520; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.52, 95% CI [2.05, 20.98], t(2008) = 2.39, p = 0.017; Std. beta = 0.43, 95%
## CI [-0.15, 1.01])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.32, 95% CI [-2.30, 42.94], t(2008) = 1.76, p = 0.078; Std. beta = 0.72,
## 95% CI [-0.72, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.21, 95% CI [-3.53, 11.95], t(2008) = 1.07, p = 0.286; Std. beta = 0.26, 95%
## CI [-0.23, 0.74])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 12.30, 95% CI [-1.20, 25.80], t(2008) = 1.79, p = 0.074; Std. beta = 0.57,
## 95% CI [-0.27, 1.40])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-9.95, 7.16], t(2008) = -0.32, p = 0.749; Std. beta = 0.18,
## 95% CI [-0.37, 0.73])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-21.07, 6.78], t(2008) = -1.01, p = 0.314; Std. beta = 0.25,
## 95% CI [-0.71, 1.22])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-3.37, 12.23], t(2008) = 1.11, p = 0.266; Std. beta = 0.30, 95%
## CI [-0.19, 0.79])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.59, 95% CI [-14.58, 3.40], t(2008) = -1.22, p = 0.223; Std. beta = -0.05,
## 95% CI [-0.61, 0.51])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-25.22, 20.66], t(2008) = -0.19, p = 0.846; Std. beta = 0.58,
## 95% CI [-0.97, 2.13])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-15.27, 24.98], t(2008) = 0.47, p = 0.636; Std. beta = 0.93,
## 95% CI [-0.30, 2.16])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.33, 95% CI [-20.79, 47.45], t(2008) = 0.77, p = 0.444; Std. beta = 0.78,
## 95% CI [-1.22, 2.78])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.16, 95% CI [0.83, 33.49], t(2008) = 2.06, p = 0.039; Std. beta = 1.41, 95%
## CI [0.39, 2.43])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.16, 95% CI [-15.18, 29.50], t(2008) = 0.63, p = 0.530; Std. beta = 0.45,
## 95% CI [-0.97, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.34, 95% CI [0.02, 34.65], t(2008) = 1.96, p = 0.050; Std. beta = 0.95, 95%
## CI [-0.12, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-23.13, 34.86], t(2008) = 0.40, p = 0.691; Std. beta = 0.68,
## 95% CI [-1.79, 3.15])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.01, 95% CI [-65.86, -2.16], t(2008) = -2.09, p = 0.036; Std. beta = -2.17,
## 95% CI [-4.46, 0.12])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-23.42, 5.37], t(2008) = -1.23, p = 0.219; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.22, 95% CI [-22.05, 42.49], t(2008) = 0.62, p = 0.535; Std. beta = 0.60,
## 95% CI [-1.29, 2.49])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.47, 95% CI [-26.47, 19.52], t(2008) = -0.30, p = 0.767; Std. beta = 0.46,
## 95% CI [-1.59, 2.51])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.78, 95% CI [-5.78, 23.35], t(2008) = 1.18, p = 0.237; Std. beta = 0.57, 95%
## CI [-0.37, 1.51])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-11.26, 15.79], t(2008) = 0.33, p = 0.743; Std. beta = 0.32,
## 95% CI [-0.57, 1.21])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.54, 95% CI [-28.41, 33.50], t(2008) = 0.16, p = 0.872; Std. beta = 0.59,
## 95% CI [-1.27, 2.45])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-13.06, 7.80], t(2008) = -0.50, p = 0.621; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-31.13, 4.59], t(2008) = -1.46, p = 0.145; Std. beta = 0.06,
## 95% CI [-3.77, 3.89])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-7.69, 17.16], t(2008) = 0.75, p = 0.455; Std. beta = 0.33, 95%
## CI [-0.44, 1.10])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-13.49, 14.58], t(2008) = 0.08, p = 0.939; Std. beta = -0.39,
## 95% CI [-1.27, 0.49])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.36, 22.66], t(2008) = 0.44, p = 0.660; Std. beta = -0.55,
## 95% CI [-2.54, 1.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-38.05, 25.29], t(2008) = -0.40, p = 0.693; Std. beta = -0.33,
## 95% CI [-2.21, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-9.59, 20.32], t(2008) = 0.70, p = 0.482; Std. beta = 0.45, 95%
## CI [-0.46, 1.35])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.28, 95% CI [-7.66, 26.23], t(2008) = 1.07, p = 0.283; Std. beta = 0.33, 95%
## CI [-0.74, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.25, 95% CI [-30.53, 2.03], t(2008) = -1.72, p = 0.086; Std. beta = -0.48,
## 95% CI [-1.57, 0.61])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.04, 95% CI [-12.61, 12.53], t(2008) = -5.84e-03, p = 0.995; Std. beta =
## 0.02, 95% CI [-0.77, 0.81])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-19.72, 18.57], t(2008) = -0.06, p = 0.953; Std. beta = 1.10,
## 95% CI [-0.12, 2.31])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-25.68, 2.81], t(2008) = -1.57, p = 0.116; Std. beta = -0.35,
## 95% CI [-1.26, 0.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.56, 95% CI [-0.42, 31.53], t(2008) = 1.91, p = 0.056; Std. beta = 0.79,
## 95% CI [-0.19, 1.78])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.33, 95% CI [0.95, 23.71], t(2008) = 2.12, p = 0.034; Std. beta = 0.54, 95%
## CI [-0.17, 1.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.79, 95% CI [-8.58, 56.15], t(2008) = 1.44, p = 0.150; Std. beta = -2.45,
## 95% CI [-4.59, -0.32])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.63, 95% CI [3.36, 47.90], t(2008) = 2.26, p = 0.024; Std. beta = 1.64, 95%
## CI [0.19, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.18, 95% CI [-22.05, 15.70], t(2008) = -0.33, p = 0.741; Std. beta = 0.03,
## 95% CI [-1.27, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-11.32, 9.25], t(2008) = -0.20, p = 0.843; Std. beta = 0.15,
## 95% CI [-0.79, 1.08])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 0.61, 95% CI [-1.40, 2.63], t(2008) = 0.60, p = 0.551;
## Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.15, 95% CI [-2.33, 2.03], t(2008) = -0.13, p = 0.893; Std.
## beta = -4.01e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.25], t(2008) =
## 0.04, p = 0.969; Std. beta = 4.10e-03, 95% CI [-0.20, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-1.43, 1.21], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.42, p = 0.155; Std.
## beta = -0.04, 95% CI [-0.10, 0.02])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.43, 95% CI [-0.90, 1.75], t(2008) =
## 0.63, p = 0.528; Std. beta = 0.04, 95% CI [-0.08, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.07, 11.78], t(2008) =
## 0.25, p = 0.799; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-1.99, 4.70], t(2008) =
## 0.80, p = 0.426; Std. beta = 0.13, 95% CI [-0.19, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.60, 95% CI [-42.76, 15.56], t(2008) = -0.91, p = 0.360;
## Std. beta = -1.27, 95% CI [-4.00, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-6.76, 13.82], t(2008) = 0.67, p = 0.501; Std.
## beta = 0.33, 95% CI [-0.63, 1.29])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.27, 95% CI [-15.34, 6.79], t(2008) = -0.76, p = 0.449; Std.
## beta = -0.40, 95% CI [-1.43, 0.63])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-12.66, 11.93], t(2008) = -0.06, p = 0.954;
## Std. beta = -0.03, 95% CI [-1.18, 1.11])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-6.15, 0.23], t(2008) = -1.82, p = 0.069; Std.
## beta = -0.28, 95% CI [-0.57, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.61, 95% CI [-14.29, 3.07], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.52, 95% CI [-1.34, 0.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-2.84, 3.06], t(2008) = 0.07, p = 0.942; Std.
## beta = 0.01, 95% CI [-0.27, 0.29])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-6.75, 3.08], t(2008) = -0.73, p = 0.465; Std.
## beta = -0.17, 95% CI [-0.63, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 3.09, 95% CI [-0.48, 6.67], t(2008) = 1.70, p = 0.090; Std.
## beta = 0.29, 95% CI [-0.05, 0.62])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.95, 95% CI [0.38, 15.53], t(2008) = 2.06, p = 0.040; Std.
## beta = 0.74, 95% CI [0.04, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.57, 3.44], t(2008) = 0.29, p = 0.775; Std.
## beta = 0.04, 95% CI [-0.24, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.47, 6.96], t(2008) = 1.71, p = 0.087; Std.
## beta = 0.30, 95% CI [-0.04, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.44, 95% CI [-4.99, 21.86], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.79, 95% CI [-0.47, 2.04])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.65, 95% CI [0.47, 14.83], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-1.28, 10.78], t(2008) = 1.54, p = 0.123; Std.
## beta = 0.44, 95% CI [-0.12, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-7.85, 8.60], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.04, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.06, 7.54], t(2008) = -0.18, p = 0.858; Std.
## beta = -0.07, 95% CI [-0.85, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.01, 95% CI [-33.29, 41.31], t(2008) = 0.21, p = 0.833; Std.
## beta = 0.37, 95% CI [-3.11, 3.86])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-24.54, 20.38], t(2008) = -0.18, p = 0.856;
## Std. beta = -0.19, 95% CI [-2.29, 1.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-2.92, 8.16], t(2008) = 0.93, p = 0.353; Std.
## beta = 0.24, 95% CI [-0.27, 0.76])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.86, 95% CI [-13.50, 29.22], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.73, 95% CI [-1.26, 2.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.66, 95% CI [-6.04, 7.36], t(2008) = 0.19, p = 0.846; Std.
## beta = 0.06, 95% CI [-0.56, 0.69])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-4.46, 8.81], t(2008) = 0.64, p = 0.520; Std.
## beta = 0.20, 95% CI [-0.42, 0.82])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-3.91, 14.40], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.49, 95% CI [-0.37, 1.35])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.27, 95% CI [-7.76, 3.23], t(2008) = -0.81, p = 0.419; Std.
## beta = -0.21, 95% CI [-0.73, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.96, 95% CI [-38.62, 58.54], t(2008) = 0.40, p = 0.688; Std.
## beta = 0.93, 95% CI [-3.61, 5.47])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-4.24, 5.50], t(2008) = 0.25, p = 0.800; Std.
## beta = 0.06, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.04, 95% CI [-10.99, 0.90], t(2008) = -1.67, p = 0.096; Std.
## beta = -0.47, 95% CI [-1.03, 0.08])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.34, 95% CI [-31.16, 12.47], t(2008) = -0.84, p = 0.401;
## Std. beta = -0.87, 95% CI [-2.91, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-9.08, 10.17], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.05, 95% CI [-0.85, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.99, 6.09], t(2008) = 0.67, p = 0.504; Std.
## beta = 0.14, 95% CI [-0.28, 0.57])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -2.49, 95% CI [-9.56, 4.59], t(2008) = -0.69, p = 0.490; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-3.72, 12.14], t(2008) = 1.04, p = 0.298; Std.
## beta = 0.39, 95% CI [-0.35, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.69, 5.31], t(2008) = 0.12, p = 0.903; Std.
## beta = 0.03, 95% CI [-0.44, 0.50])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 13.41, 95% CI [4.81, 22.02], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.25, 95% CI [0.45, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.74, 95% CI [-1.92, 9.41], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-7.09, 4.32], t(2008) = -0.48, p = 0.633; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-6.34, 2.06], t(2008) = -1.00, p = 0.318; Std.
## beta = -0.20, 95% CI [-0.59, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.58, 95% CI [-62.82, -28.34], t(2008) = -5.19, p < .001;
## Std. beta = -4.26, 95% CI [-5.87, -2.65])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-7.50, 10.78], t(2008) = 0.35, p = 0.725; Std.
## beta = 0.15, 95% CI [-0.70, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-8.54, 13.68], t(2008) = 0.45, p = 0.650; Std.
## beta = 0.24, 95% CI [-0.80, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-8.20, 13.15], t(2008) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.77, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*BC_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14372.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3220 -0.4375 -0.0180 0.4490 4.5204
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 256.23 16.007
## time_firstPFT 13.02 3.608 -0.11
## Residual 25.70 5.070
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 58.68014 4.01029 14.632
## time_firstPFT -3.17533 1.60405 -1.980
## BC_5yrPreDx 0.83691 4.31228 0.194
## site02R -7.47980 16.85517 -0.444
## site03R 13.96052 12.07325 1.156
## site04R 3.50534 11.77359 0.298
## site05R -11.06357 9.70846 -1.140
## site06R 20.16430 11.94619 1.688
## site07R 13.06777 4.88699 2.674
## site09R 21.99302 11.86074 1.854
## site101 3.63614 3.64534 0.997
## site102 11.55800 6.63296 1.743
## site103 -0.44959 3.33826 -0.135
## site104 -4.87410 6.93443 -0.703
## site105 4.99280 3.53511 1.412
## site106 -3.43463 4.35715 -0.788
## site107 -4.46443 12.01296 -0.372
## site108 0.96670 9.94412 0.097
## site10R 14.59661 17.51160 0.834
## site11R 20.57725 8.27081 2.488
## site12R 12.05529 11.88529 1.014
## site13R 16.27453 8.88662 1.831
## site14R 7.31717 15.04577 0.486
## site15R -27.72633 16.87852 -1.643
## site16R -14.95988 7.49788 -1.995
## site17R 6.18445 16.87438 0.366
## site18R 0.85028 11.97476 0.071
## site19R 10.50599 7.32778 1.434
## site20R 4.01018 7.03198 0.570
## site21R 4.08222 16.39964 0.249
## site22R 1.46730 5.29542 0.277
## site23R -10.20771 7.73320 -1.320
## site24R 6.43815 6.51855 0.988
## site25R 2.05286 7.01219 0.293
## site28R 0.73425 9.79061 0.075
## site29R -3.32713 16.75153 -0.199
## site31R 4.44783 7.49135 0.594
## site32R 12.50139 8.53157 1.465
## site33R -15.31036 8.47252 -1.807
## site34R 2.85883 6.54886 0.437
## site35R 6.53245 9.92672 0.658
## site36R -12.42192 7.52374 -1.651
## site37R 13.11096 8.32690 1.575
## site38R 12.76462 5.67973 2.247
## site39R 19.18386 16.79690 1.142
## site40R 28.45720 11.83125 2.405
## site41R -0.55086 9.71762 -0.057
## site42R -0.09457 5.24244 -0.018
## time_firstPFT:BC_5yrPreDx -1.15156 1.70406 -0.676
## time_firstPFT:site02R -15.40280 14.75982 -1.044
## time_firstPFT:site03R 1.51907 5.02385 0.302
## time_firstPFT:site04R -5.32906 5.53158 -0.963
## time_firstPFT:site05R -0.84554 6.21929 -0.136
## time_firstPFT:site06R -2.93782 4.78825 -0.614
## time_firstPFT:site07R -4.20740 1.46988 -2.862
## time_firstPFT:site09R -6.49978 4.22965 -1.537
## time_firstPFT:site101 -1.14271 1.25210 -0.913
## time_firstPFT:site102 -3.03017 2.21146 -1.370
## time_firstPFT:site103 1.48076 1.20216 1.232
## time_firstPFT:site104 5.95417 3.52451 1.689
## time_firstPFT:site105 -0.69555 1.20792 -0.576
## time_firstPFT:site106 1.76363 1.64808 1.070
## time_firstPFT:site107 7.20375 6.73457 1.070
## time_firstPFT:site108 5.86575 3.22991 1.816
## time_firstPFT:site11R 3.30727 2.76294 1.197
## time_firstPFT:site12R -0.57442 4.09778 -0.140
## time_firstPFT:site13R -2.10343 4.04020 -0.521
## time_firstPFT:site14R 2.89373 18.96171 0.153
## time_firstPFT:site15R -2.60390 11.38637 -0.229
## time_firstPFT:site16R 2.26175 2.62536 0.862
## time_firstPFT:site18R 6.39161 10.79404 0.592
## time_firstPFT:site19R -1.59985 3.17327 -0.504
## time_firstPFT:site20R 0.48833 3.19612 0.153
## time_firstPFT:site21R 4.58139 4.49211 1.020
## time_firstPFT:site22R -3.64371 2.66668 -1.366
## time_firstPFT:site23R 1.05589 5.03572 0.210
## time_firstPFT:site24R -0.36308 2.36985 -0.153
## time_firstPFT:site25R -6.85190 2.78266 -2.462
## time_firstPFT:site28R -11.34716 10.98050 -1.033
## time_firstPFT:site29R -1.00547 4.74841 -0.212
## time_firstPFT:site31R 0.49287 1.97080 0.250
## time_firstPFT:site32R -4.22407 3.28039 -1.288
## time_firstPFT:site33R 2.66410 3.87943 0.687
## time_firstPFT:site34R -0.90143 2.39642 -0.376
## time_firstPFT:site35R 11.18655 4.21518 2.654
## time_firstPFT:site36R 3.44188 2.82335 1.219
## time_firstPFT:site37R -2.42820 2.72474 -0.891
## time_firstPFT:site38R -3.21737 1.85266 -1.737
## time_firstPFT:site39R -46.67810 8.59676 -5.430
## time_firstPFT:site40R -0.55924 4.53155 -0.123
## time_firstPFT:site41R 0.97200 5.53575 0.176
## time_firstPFT:site42R 1.11396 5.39496 0.206##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.920
## Unadjusted ICC: 0.741report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## BC_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 58.68 (95% CI [50.82,
## 66.54], t(2038) = 14.63, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.18, 95% CI [-6.32, -0.03], t(2038) = -1.98, p = 0.048; Std. beta = -0.37,
## 95% CI [-0.48, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 0.84, 95% CI [-7.62, 9.29], t(2038) = 0.19, p = 0.846; Std. beta = -0.01, 95%
## CI [-0.15, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-40.53, 25.58], t(2038) = -0.44, p = 0.657; Std. beta = -1.73,
## 95% CI [-4.43, 0.96])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.96, 95% CI [-9.72, 37.64], t(2038) = 1.16, p = 0.248; Std. beta = 0.95,
## 95% CI [-0.45, 2.34])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-19.58, 26.59], t(2038) = 0.30, p = 0.766; Std. beta = -0.24,
## 95% CI [-1.73, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.06, 95% CI [-30.10, 7.98], t(2038) = -1.14, p = 0.255; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.16, 95% CI [-3.26, 43.59], t(2038) = 1.69, p = 0.092; Std. beta = 0.94,
## 95% CI [-0.54, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.07, 95% CI [3.48, 22.65], t(2038) = 2.67, p = 0.008; Std. beta = 0.41, 95%
## CI [-0.16, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-1.27, 45.25], t(2038) = 1.85, p = 0.064; Std. beta = 0.74,
## 95% CI [-0.70, 2.18])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-3.51, 10.79], t(2038) = 1.00, p = 0.319; Std. beta = 0.12, 95%
## CI [-0.32, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.56, 95% CI [-1.45, 24.57], t(2038) = 1.74, p = 0.082; Std. beta = 0.42,
## 95% CI [-0.36, 1.21])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-7.00, 6.10], t(2038) = -0.13, p = 0.893; Std. beta = 0.10,
## 95% CI [-0.31, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-18.47, 8.73], t(2038) = -0.70, p = 0.482; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.99, 95% CI [-1.94, 11.93], t(2038) = 1.41, p = 0.158; Std. beta = 0.23, 95%
## CI [-0.19, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.98, 5.11], t(2038) = -0.79, p = 0.431; Std. beta = -0.05,
## 95% CI [-0.57, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-28.02, 19.09], t(2038) = -0.37, p = 0.710; Std. beta = 0.34,
## 95% CI [-1.21, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-18.54, 20.47], t(2038) = 0.10, p = 0.923; Std. beta = 0.55,
## 95% CI [-0.61, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.60, 95% CI [-19.75, 48.94], t(2038) = 0.83, p = 0.405; Std. beta = 0.86,
## 95% CI [-1.16, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.58, 95% CI [4.36, 36.80], t(2038) = 2.49, p = 0.013; Std. beta = 1.48, 95%
## CI [0.50, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.06, 95% CI [-11.25, 35.36], t(2038) = 1.01, p = 0.311; Std. beta = 0.66,
## 95% CI [-0.79, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.27, 95% CI [-1.15, 33.70], t(2038) = 1.83, p = 0.067; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-22.19, 36.82], t(2038) = 0.49, p = 0.627; Std. beta = 0.67,
## 95% CI [-1.79, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.73, 95% CI [-60.83, 5.37], t(2038) = -1.64, p = 0.101; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.96, 95% CI [-29.66, -0.26], t(2038) = -2.00, p = 0.046; Std. beta = -0.69,
## 95% CI [-1.60, 0.22])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.18, 95% CI [-26.91, 39.28], t(2038) = 0.37, p = 0.714; Std. beta = 0.36,
## 95% CI [-1.58, 2.30])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.85, 95% CI [-22.63, 24.33], t(2038) = 0.07, p = 0.943; Std. beta = 0.59,
## 95% CI [-1.45, 2.62])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.51, 95% CI [-3.86, 24.88], t(2038) = 1.43, p = 0.152; Std. beta = 0.48,
## 95% CI [-0.42, 1.39])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-9.78, 17.80], t(2038) = 0.57, p = 0.569; Std. beta = 0.28, 95%
## CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.08, 36.24], t(2038) = 0.25, p = 0.803; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-8.92, 11.85], t(2038) = 0.28, p = 0.782; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.21, 95% CI [-25.37, 4.96], t(2038) = -1.32, p = 0.187; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.44, 95% CI [-6.35, 19.22], t(2038) = 0.99, p = 0.323; Std. beta = 0.35, 95%
## CI [-0.43, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-11.70, 15.80], t(2038) = 0.29, p = 0.770; Std. beta = -0.46,
## 95% CI [-1.30, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-18.47, 19.93], t(2038) = 0.07, p = 0.940; Std. beta = -0.91,
## 95% CI [-2.89, 1.07])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.33, 95% CI [-36.18, 29.52], t(2038) = -0.20, p = 0.843; Std. beta = -0.28,
## 95% CI [-2.19, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-10.24, 19.14], t(2038) = 0.59, p = 0.553; Std. beta = 0.30,
## 95% CI [-0.56, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.50, 95% CI [-4.23, 29.23], t(2038) = 1.47, p = 0.143; Std. beta = 0.38,
## 95% CI [-0.65, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.31, 95% CI [-31.93, 1.31], t(2038) = -1.81, p = 0.071; Std. beta = -0.67,
## 95% CI [-1.76, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.86, 95% CI [-9.98, 15.70], t(2038) = 0.44, p = 0.662; Std. beta = 0.09, 95%
## CI [-0.69, 0.88])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-12.94, 26.00], t(2038) = 0.66, p = 0.511; Std. beta = 1.32,
## 95% CI [0.12, 2.53])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.18, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.44,
## 95% CI [-1.36, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.11, 95% CI [-3.22, 29.44], t(2038) = 1.57, p = 0.116; Std. beta = 0.56,
## 95% CI [-0.41, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.76, 95% CI [1.63, 23.90], t(2038) = 2.25, p = 0.025; Std. beta = 0.48, 95%
## CI [-0.19, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-13.76, 52.12], t(2038) = 1.14, p = 0.254; Std. beta = -2.80,
## 95% CI [-4.92, -0.68])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.46, 95% CI [5.25, 51.66], t(2038) = 2.41, p = 0.016; Std. beta = 1.62, 95%
## CI [0.15, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.55, 95% CI [-19.61, 18.51], t(2038) = -0.06, p = 0.955; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-10.38, 10.19], t(2038) = -0.02, p = 0.986; Std. beta = 0.09,
## 95% CI [-0.83, 1.01])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.15, 95% CI [-4.49, 2.19], t(2038) = -0.68, p = 0.499;
## Std. beta = -0.03, 95% CI [-0.11, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.40, 95% CI [-44.35, 13.54], t(2038) = -1.04, p = 0.297;
## Std. beta = -1.44, 95% CI [-4.13, 1.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-8.33, 11.37], t(2038) = 0.30, p = 0.762; Std.
## beta = 0.14, 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.33, 95% CI [-16.18, 5.52], t(2038) = -0.96, p = 0.335; Std.
## beta = -0.50, 95% CI [-1.51, 0.51])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-13.04, 11.35], t(2038) = -0.14, p = 0.892;
## Std. beta = -0.08, 95% CI [-1.22, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-12.33, 6.45], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.27, 95% CI [-1.15, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.21, 95% CI [-7.09, -1.32], t(2038) = -2.86, p = 0.004; Std.
## beta = -0.39, 95% CI [-0.66, -0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.50, 95% CI [-14.79, 1.80], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.61, 95% CI [-1.38, 0.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-3.60, 1.31], t(2038) = -0.91, p = 0.362; Std.
## beta = -0.11, 95% CI [-0.34, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.37, 1.31], t(2038) = -1.37, p = 0.171; Std.
## beta = -0.28, 95% CI [-0.69, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-0.88, 3.84], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.95, 95% CI [-0.96, 12.87], t(2038) = 1.69, p = 0.091; Std.
## beta = 0.56, 95% CI [-0.09, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-3.06, 1.67], t(2038) = -0.58, p = 0.565; Std.
## beta = -0.06, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-1.47, 5.00], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.16, 95% CI [-0.14, 0.47])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.20, 95% CI [-6.00, 20.41], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.67, 95% CI [-0.56, 1.90])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.87, 95% CI [-0.47, 12.20], t(2038) = 1.82, p = 0.070; Std.
## beta = 0.55, 95% CI [-0.04, 1.14])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.11, 8.73], t(2038) = 1.20, p = 0.231; Std.
## beta = 0.31, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.61, 7.46], t(2038) = -0.14, p = 0.889; Std.
## beta = -0.05, 95% CI [-0.80, 0.70])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-10.03, 5.82], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.20, 95% CI [-0.93, 0.54])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-34.29, 40.08], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.27, 95% CI [-3.20, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-24.93, 19.73], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-2.89, 7.41], t(2038) = 0.86, p = 0.389; Std.
## beta = 0.21, 95% CI [-0.27, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.39, 95% CI [-14.78, 27.56], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.60, 95% CI [-1.38, 2.57])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.82, 4.62], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.15, 95% CI [-0.73, 0.43])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-5.78, 6.76], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.23, 13.39], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.43, 95% CI [-0.39, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-8.87, 1.59], t(2038) = -1.37, p = 0.172; Std.
## beta = -0.34, 95% CI [-0.83, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-8.82, 10.93], t(2038) = 0.21, p = 0.834; Std.
## beta = 0.10, 95% CI [-0.82, 1.02])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.01, 4.28], t(2038) = -0.15, p = 0.878; Std.
## beta = -0.03, 95% CI [-0.47, 0.40])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.85, 95% CI [-12.31, -1.39], t(2038) = -2.46, p = 0.014;
## Std. beta = -0.64, 95% CI [-1.15, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.35, 95% CI [-32.88, 10.19], t(2038) = -1.03, p = 0.302;
## Std. beta = -1.06, 95% CI [-3.07, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-10.32, 8.31], t(2038) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.96, 0.77])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-3.37, 4.36], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.05, 95% CI [-0.31, 0.41])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-10.66, 2.21], t(2038) = -1.29, p = 0.198; Std.
## beta = -0.39, 95% CI [-0.99, 0.21])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-4.94, 10.27], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.25, 95% CI [-0.46, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-5.60, 3.80], t(2038) = -0.38, p = 0.707; Std.
## beta = -0.08, 95% CI [-0.52, 0.35])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.19, 95% CI [2.92, 19.45], t(2038) = 2.65, p = 0.008; Std.
## beta = 1.04, 95% CI [0.27, 1.81])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-2.10, 8.98], t(2038) = 1.22, p = 0.223; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.43, 95% CI [-7.77, 2.92], t(2038) = -0.89, p = 0.373; Std.
## beta = -0.23, 95% CI [-0.72, 0.27])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.22, 95% CI [-6.85, 0.42], t(2038) = -1.74, p = 0.083; Std.
## beta = -0.30, 95% CI [-0.64, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.68, 95% CI [-63.54, -29.82], t(2038) = -5.43, p < .001;
## Std. beta = -4.35, 95% CI [-5.92, -2.78])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.56, 95% CI [-9.45, 8.33], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.05, 95% CI [-0.88, 0.78])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.88, 11.83], t(2038) = 0.18, p = 0.861; Std.
## beta = 0.09, 95% CI [-0.92, 1.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-9.47, 11.69], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.10, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## BC_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to
## BC_5yrPreDx = 0, is at 58.68 (95% CI [50.82, 66.54], t(2038) = 14.63, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.18, 95% CI [-6.32, -0.03], t(2038) = -1.98, p = 0.048; Std. beta = -0.37,
## 95% CI [-0.48, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 0.84, 95% CI [-7.62, 9.29], t(2038) = 0.19, p = 0.846; Std. beta = -0.01, 95%
## CI [-0.15, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-40.53, 25.58], t(2038) = -0.44, p = 0.657; Std. beta = -1.73,
## 95% CI [-4.43, 0.96])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.96, 95% CI [-9.72, 37.64], t(2038) = 1.16, p = 0.248; Std. beta = 0.95,
## 95% CI [-0.45, 2.34])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-19.58, 26.59], t(2038) = 0.30, p = 0.766; Std. beta = -0.24,
## 95% CI [-1.73, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.06, 95% CI [-30.10, 7.98], t(2038) = -1.14, p = 0.255; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.16, 95% CI [-3.26, 43.59], t(2038) = 1.69, p = 0.092; Std. beta = 0.94,
## 95% CI [-0.54, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.07, 95% CI [3.48, 22.65], t(2038) = 2.67, p = 0.008; Std. beta = 0.41, 95%
## CI [-0.16, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-1.27, 45.25], t(2038) = 1.85, p = 0.064; Std. beta = 0.74,
## 95% CI [-0.70, 2.18])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-3.51, 10.79], t(2038) = 1.00, p = 0.319; Std. beta = 0.12, 95%
## CI [-0.32, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.56, 95% CI [-1.45, 24.57], t(2038) = 1.74, p = 0.082; Std. beta = 0.42,
## 95% CI [-0.36, 1.21])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-7.00, 6.10], t(2038) = -0.13, p = 0.893; Std. beta = 0.10,
## 95% CI [-0.31, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-18.47, 8.73], t(2038) = -0.70, p = 0.482; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.99, 95% CI [-1.94, 11.93], t(2038) = 1.41, p = 0.158; Std. beta = 0.23, 95%
## CI [-0.19, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.98, 5.11], t(2038) = -0.79, p = 0.431; Std. beta = -0.05,
## 95% CI [-0.57, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-28.02, 19.09], t(2038) = -0.37, p = 0.710; Std. beta = 0.34,
## 95% CI [-1.21, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-18.54, 20.47], t(2038) = 0.10, p = 0.923; Std. beta = 0.55,
## 95% CI [-0.61, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.60, 95% CI [-19.75, 48.94], t(2038) = 0.83, p = 0.405; Std. beta = 0.86,
## 95% CI [-1.16, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.58, 95% CI [4.36, 36.80], t(2038) = 2.49, p = 0.013; Std. beta = 1.48, 95%
## CI [0.50, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.06, 95% CI [-11.25, 35.36], t(2038) = 1.01, p = 0.311; Std. beta = 0.66,
## 95% CI [-0.79, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.27, 95% CI [-1.15, 33.70], t(2038) = 1.83, p = 0.067; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-22.19, 36.82], t(2038) = 0.49, p = 0.627; Std. beta = 0.67,
## 95% CI [-1.79, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.73, 95% CI [-60.83, 5.37], t(2038) = -1.64, p = 0.101; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.96, 95% CI [-29.66, -0.26], t(2038) = -2.00, p = 0.046; Std. beta = -0.69,
## 95% CI [-1.60, 0.22])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.18, 95% CI [-26.91, 39.28], t(2038) = 0.37, p = 0.714; Std. beta = 0.36,
## 95% CI [-1.58, 2.30])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.85, 95% CI [-22.63, 24.33], t(2038) = 0.07, p = 0.943; Std. beta = 0.59,
## 95% CI [-1.45, 2.62])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.51, 95% CI [-3.86, 24.88], t(2038) = 1.43, p = 0.152; Std. beta = 0.48,
## 95% CI [-0.42, 1.39])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-9.78, 17.80], t(2038) = 0.57, p = 0.569; Std. beta = 0.28, 95%
## CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.08, 36.24], t(2038) = 0.25, p = 0.803; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-8.92, 11.85], t(2038) = 0.28, p = 0.782; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.21, 95% CI [-25.37, 4.96], t(2038) = -1.32, p = 0.187; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.44, 95% CI [-6.35, 19.22], t(2038) = 0.99, p = 0.323; Std. beta = 0.35, 95%
## CI [-0.43, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-11.70, 15.80], t(2038) = 0.29, p = 0.770; Std. beta = -0.46,
## 95% CI [-1.30, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-18.47, 19.93], t(2038) = 0.07, p = 0.940; Std. beta = -0.91,
## 95% CI [-2.89, 1.07])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.33, 95% CI [-36.18, 29.52], t(2038) = -0.20, p = 0.843; Std. beta = -0.28,
## 95% CI [-2.19, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-10.24, 19.14], t(2038) = 0.59, p = 0.553; Std. beta = 0.30,
## 95% CI [-0.56, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.50, 95% CI [-4.23, 29.23], t(2038) = 1.47, p = 0.143; Std. beta = 0.38,
## 95% CI [-0.65, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.31, 95% CI [-31.93, 1.31], t(2038) = -1.81, p = 0.071; Std. beta = -0.67,
## 95% CI [-1.76, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.86, 95% CI [-9.98, 15.70], t(2038) = 0.44, p = 0.662; Std. beta = 0.09, 95%
## CI [-0.69, 0.88])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-12.94, 26.00], t(2038) = 0.66, p = 0.511; Std. beta = 1.32,
## 95% CI [0.12, 2.53])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.18, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.44,
## 95% CI [-1.36, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.11, 95% CI [-3.22, 29.44], t(2038) = 1.57, p = 0.116; Std. beta = 0.56,
## 95% CI [-0.41, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.76, 95% CI [1.63, 23.90], t(2038) = 2.25, p = 0.025; Std. beta = 0.48, 95%
## CI [-0.19, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-13.76, 52.12], t(2038) = 1.14, p = 0.254; Std. beta = -2.80,
## 95% CI [-4.92, -0.68])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.46, 95% CI [5.25, 51.66], t(2038) = 2.41, p = 0.016; Std. beta = 1.62, 95%
## CI [0.15, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.55, 95% CI [-19.61, 18.51], t(2038) = -0.06, p = 0.955; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-10.38, 10.19], t(2038) = -0.02, p = 0.986; Std. beta = 0.09,
## 95% CI [-0.83, 1.01])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.15, 95% CI [-4.49, 2.19], t(2038) = -0.68, p = 0.499;
## Std. beta = -0.03, 95% CI [-0.11, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.40, 95% CI [-44.35, 13.54], t(2038) = -1.04, p = 0.297;
## Std. beta = -1.44, 95% CI [-4.13, 1.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-8.33, 11.37], t(2038) = 0.30, p = 0.762; Std.
## beta = 0.14, 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.33, 95% CI [-16.18, 5.52], t(2038) = -0.96, p = 0.335; Std.
## beta = -0.50, 95% CI [-1.51, 0.51])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-13.04, 11.35], t(2038) = -0.14, p = 0.892;
## Std. beta = -0.08, 95% CI [-1.22, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-12.33, 6.45], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.27, 95% CI [-1.15, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.21, 95% CI [-7.09, -1.32], t(2038) = -2.86, p = 0.004; Std.
## beta = -0.39, 95% CI [-0.66, -0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.50, 95% CI [-14.79, 1.80], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.61, 95% CI [-1.38, 0.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-3.60, 1.31], t(2038) = -0.91, p = 0.362; Std.
## beta = -0.11, 95% CI [-0.34, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.37, 1.31], t(2038) = -1.37, p = 0.171; Std.
## beta = -0.28, 95% CI [-0.69, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-0.88, 3.84], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.95, 95% CI [-0.96, 12.87], t(2038) = 1.69, p = 0.091; Std.
## beta = 0.56, 95% CI [-0.09, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-3.06, 1.67], t(2038) = -0.58, p = 0.565; Std.
## beta = -0.06, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-1.47, 5.00], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.16, 95% CI [-0.14, 0.47])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.20, 95% CI [-6.00, 20.41], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.67, 95% CI [-0.56, 1.90])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.87, 95% CI [-0.47, 12.20], t(2038) = 1.82, p = 0.070; Std.
## beta = 0.55, 95% CI [-0.04, 1.14])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.11, 8.73], t(2038) = 1.20, p = 0.231; Std.
## beta = 0.31, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.61, 7.46], t(2038) = -0.14, p = 0.889; Std.
## beta = -0.05, 95% CI [-0.80, 0.70])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-10.03, 5.82], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.20, 95% CI [-0.93, 0.54])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-34.29, 40.08], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.27, 95% CI [-3.20, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-24.93, 19.73], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-2.89, 7.41], t(2038) = 0.86, p = 0.389; Std.
## beta = 0.21, 95% CI [-0.27, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.39, 95% CI [-14.78, 27.56], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.60, 95% CI [-1.38, 2.57])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.82, 4.62], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.15, 95% CI [-0.73, 0.43])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-5.78, 6.76], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.23, 13.39], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.43, 95% CI [-0.39, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-8.87, 1.59], t(2038) = -1.37, p = 0.172; Std.
## beta = -0.34, 95% CI [-0.83, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-8.82, 10.93], t(2038) = 0.21, p = 0.834; Std.
## beta = 0.10, 95% CI [-0.82, 1.02])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.01, 4.28], t(2038) = -0.15, p = 0.878; Std.
## beta = -0.03, 95% CI [-0.47, 0.40])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.85, 95% CI [-12.31, -1.39], t(2038) = -2.46, p = 0.014;
## Std. beta = -0.64, 95% CI [-1.15, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.35, 95% CI [-32.88, 10.19], t(2038) = -1.03, p = 0.302;
## Std. beta = -1.06, 95% CI [-3.07, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-10.32, 8.31], t(2038) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.96, 0.77])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-3.37, 4.36], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.05, 95% CI [-0.31, 0.41])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-10.66, 2.21], t(2038) = -1.29, p = 0.198; Std.
## beta = -0.39, 95% CI [-0.99, 0.21])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-4.94, 10.27], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.25, 95% CI [-0.46, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-5.60, 3.80], t(2038) = -0.38, p = 0.707; Std.
## beta = -0.08, 95% CI [-0.52, 0.35])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.19, 95% CI [2.92, 19.45], t(2038) = 2.65, p = 0.008; Std.
## beta = 1.04, 95% CI [0.27, 1.81])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-2.10, 8.98], t(2038) = 1.22, p = 0.223; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.43, 95% CI [-7.77, 2.92], t(2038) = -0.89, p = 0.373; Std.
## beta = -0.23, 95% CI [-0.72, 0.27])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.22, 95% CI [-6.85, 0.42], t(2038) = -1.74, p = 0.083; Std.
## beta = -0.30, 95% CI [-0.64, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.68, 95% CI [-63.54, -29.82], t(2038) = -5.43, p < .001;
## Std. beta = -4.35, 95% CI [-5.92, -2.78])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.56, 95% CI [-9.45, 8.33], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.05, 95% CI [-0.88, 0.78])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.88, 11.83], t(2038) = 0.18, p = 0.861; Std.
## beta = 0.09, 95% CI [-0.92, 1.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-9.47, 11.69], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.10, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT * site
## + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 58.68 (95% CI [50.82, 66.54], t(2038) = 14.63, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.18, 95% CI [-6.32, -0.03], t(2038) = -1.98, p = 0.048; Std. beta = -0.37,
## 95% CI [-0.48, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 0.84, 95% CI [-7.62, 9.29], t(2038) = 0.19, p = 0.846; Std. beta = -0.01, 95%
## CI [-0.15, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-40.53, 25.58], t(2038) = -0.44, p = 0.657; Std. beta = -1.73,
## 95% CI [-4.43, 0.96])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.96, 95% CI [-9.72, 37.64], t(2038) = 1.16, p = 0.248; Std. beta = 0.95,
## 95% CI [-0.45, 2.34])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-19.58, 26.59], t(2038) = 0.30, p = 0.766; Std. beta = -0.24,
## 95% CI [-1.73, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.06, 95% CI [-30.10, 7.98], t(2038) = -1.14, p = 0.255; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.16, 95% CI [-3.26, 43.59], t(2038) = 1.69, p = 0.092; Std. beta = 0.94,
## 95% CI [-0.54, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.07, 95% CI [3.48, 22.65], t(2038) = 2.67, p = 0.008; Std. beta = 0.41, 95%
## CI [-0.16, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-1.27, 45.25], t(2038) = 1.85, p = 0.064; Std. beta = 0.74,
## 95% CI [-0.70, 2.18])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-3.51, 10.79], t(2038) = 1.00, p = 0.319; Std. beta = 0.12, 95%
## CI [-0.32, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.56, 95% CI [-1.45, 24.57], t(2038) = 1.74, p = 0.082; Std. beta = 0.42,
## 95% CI [-0.36, 1.21])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-7.00, 6.10], t(2038) = -0.13, p = 0.893; Std. beta = 0.10,
## 95% CI [-0.31, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-18.47, 8.73], t(2038) = -0.70, p = 0.482; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.99, 95% CI [-1.94, 11.93], t(2038) = 1.41, p = 0.158; Std. beta = 0.23, 95%
## CI [-0.19, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.98, 5.11], t(2038) = -0.79, p = 0.431; Std. beta = -0.05,
## 95% CI [-0.57, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-28.02, 19.09], t(2038) = -0.37, p = 0.710; Std. beta = 0.34,
## 95% CI [-1.21, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-18.54, 20.47], t(2038) = 0.10, p = 0.923; Std. beta = 0.55,
## 95% CI [-0.61, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.60, 95% CI [-19.75, 48.94], t(2038) = 0.83, p = 0.405; Std. beta = 0.86,
## 95% CI [-1.16, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.58, 95% CI [4.36, 36.80], t(2038) = 2.49, p = 0.013; Std. beta = 1.48, 95%
## CI [0.50, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.06, 95% CI [-11.25, 35.36], t(2038) = 1.01, p = 0.311; Std. beta = 0.66,
## 95% CI [-0.79, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.27, 95% CI [-1.15, 33.70], t(2038) = 1.83, p = 0.067; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-22.19, 36.82], t(2038) = 0.49, p = 0.627; Std. beta = 0.67,
## 95% CI [-1.79, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.73, 95% CI [-60.83, 5.37], t(2038) = -1.64, p = 0.101; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.96, 95% CI [-29.66, -0.26], t(2038) = -2.00, p = 0.046; Std. beta = -0.69,
## 95% CI [-1.60, 0.22])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.18, 95% CI [-26.91, 39.28], t(2038) = 0.37, p = 0.714; Std. beta = 0.36,
## 95% CI [-1.58, 2.30])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.85, 95% CI [-22.63, 24.33], t(2038) = 0.07, p = 0.943; Std. beta = 0.59,
## 95% CI [-1.45, 2.62])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.51, 95% CI [-3.86, 24.88], t(2038) = 1.43, p = 0.152; Std. beta = 0.48,
## 95% CI [-0.42, 1.39])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-9.78, 17.80], t(2038) = 0.57, p = 0.569; Std. beta = 0.28, 95%
## CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.08, 36.24], t(2038) = 0.25, p = 0.803; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-8.92, 11.85], t(2038) = 0.28, p = 0.782; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.21, 95% CI [-25.37, 4.96], t(2038) = -1.32, p = 0.187; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.44, 95% CI [-6.35, 19.22], t(2038) = 0.99, p = 0.323; Std. beta = 0.35, 95%
## CI [-0.43, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-11.70, 15.80], t(2038) = 0.29, p = 0.770; Std. beta = -0.46,
## 95% CI [-1.30, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-18.47, 19.93], t(2038) = 0.07, p = 0.940; Std. beta = -0.91,
## 95% CI [-2.89, 1.07])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.33, 95% CI [-36.18, 29.52], t(2038) = -0.20, p = 0.843; Std. beta = -0.28,
## 95% CI [-2.19, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-10.24, 19.14], t(2038) = 0.59, p = 0.553; Std. beta = 0.30,
## 95% CI [-0.56, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.50, 95% CI [-4.23, 29.23], t(2038) = 1.47, p = 0.143; Std. beta = 0.38,
## 95% CI [-0.65, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.31, 95% CI [-31.93, 1.31], t(2038) = -1.81, p = 0.071; Std. beta = -0.67,
## 95% CI [-1.76, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.86, 95% CI [-9.98, 15.70], t(2038) = 0.44, p = 0.662; Std. beta = 0.09, 95%
## CI [-0.69, 0.88])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-12.94, 26.00], t(2038) = 0.66, p = 0.511; Std. beta = 1.32,
## 95% CI [0.12, 2.53])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.18, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.44,
## 95% CI [-1.36, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.11, 95% CI [-3.22, 29.44], t(2038) = 1.57, p = 0.116; Std. beta = 0.56,
## 95% CI [-0.41, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.76, 95% CI [1.63, 23.90], t(2038) = 2.25, p = 0.025; Std. beta = 0.48, 95%
## CI [-0.19, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-13.76, 52.12], t(2038) = 1.14, p = 0.254; Std. beta = -2.80,
## 95% CI [-4.92, -0.68])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.46, 95% CI [5.25, 51.66], t(2038) = 2.41, p = 0.016; Std. beta = 1.62, 95%
## CI [0.15, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.55, 95% CI [-19.61, 18.51], t(2038) = -0.06, p = 0.955; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-10.38, 10.19], t(2038) = -0.02, p = 0.986; Std. beta = 0.09,
## 95% CI [-0.83, 1.01])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.15, 95% CI [-4.49, 2.19], t(2038) = -0.68, p = 0.499;
## Std. beta = -0.03, 95% CI [-0.11, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.40, 95% CI [-44.35, 13.54], t(2038) = -1.04, p = 0.297;
## Std. beta = -1.44, 95% CI [-4.13, 1.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-8.33, 11.37], t(2038) = 0.30, p = 0.762; Std.
## beta = 0.14, 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.33, 95% CI [-16.18, 5.52], t(2038) = -0.96, p = 0.335; Std.
## beta = -0.50, 95% CI [-1.51, 0.51])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-13.04, 11.35], t(2038) = -0.14, p = 0.892;
## Std. beta = -0.08, 95% CI [-1.22, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-12.33, 6.45], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.27, 95% CI [-1.15, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.21, 95% CI [-7.09, -1.32], t(2038) = -2.86, p = 0.004; Std.
## beta = -0.39, 95% CI [-0.66, -0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.50, 95% CI [-14.79, 1.80], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.61, 95% CI [-1.38, 0.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-3.60, 1.31], t(2038) = -0.91, p = 0.362; Std.
## beta = -0.11, 95% CI [-0.34, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.37, 1.31], t(2038) = -1.37, p = 0.171; Std.
## beta = -0.28, 95% CI [-0.69, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-0.88, 3.84], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.95, 95% CI [-0.96, 12.87], t(2038) = 1.69, p = 0.091; Std.
## beta = 0.56, 95% CI [-0.09, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-3.06, 1.67], t(2038) = -0.58, p = 0.565; Std.
## beta = -0.06, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-1.47, 5.00], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.16, 95% CI [-0.14, 0.47])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.20, 95% CI [-6.00, 20.41], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.67, 95% CI [-0.56, 1.90])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.87, 95% CI [-0.47, 12.20], t(2038) = 1.82, p = 0.070; Std.
## beta = 0.55, 95% CI [-0.04, 1.14])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.11, 8.73], t(2038) = 1.20, p = 0.231; Std.
## beta = 0.31, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.61, 7.46], t(2038) = -0.14, p = 0.889; Std.
## beta = -0.05, 95% CI [-0.80, 0.70])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-10.03, 5.82], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.20, 95% CI [-0.93, 0.54])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-34.29, 40.08], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.27, 95% CI [-3.20, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-24.93, 19.73], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-2.89, 7.41], t(2038) = 0.86, p = 0.389; Std.
## beta = 0.21, 95% CI [-0.27, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.39, 95% CI [-14.78, 27.56], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.60, 95% CI [-1.38, 2.57])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.82, 4.62], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.15, 95% CI [-0.73, 0.43])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-5.78, 6.76], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.23, 13.39], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.43, 95% CI [-0.39, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-8.87, 1.59], t(2038) = -1.37, p = 0.172; Std.
## beta = -0.34, 95% CI [-0.83, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-8.82, 10.93], t(2038) = 0.21, p = 0.834; Std.
## beta = 0.10, 95% CI [-0.82, 1.02])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.01, 4.28], t(2038) = -0.15, p = 0.878; Std.
## beta = -0.03, 95% CI [-0.47, 0.40])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.85, 95% CI [-12.31, -1.39], t(2038) = -2.46, p = 0.014;
## Std. beta = -0.64, 95% CI [-1.15, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.35, 95% CI [-32.88, 10.19], t(2038) = -1.03, p = 0.302;
## Std. beta = -1.06, 95% CI [-3.07, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-10.32, 8.31], t(2038) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.96, 0.77])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-3.37, 4.36], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.05, 95% CI [-0.31, 0.41])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-10.66, 2.21], t(2038) = -1.29, p = 0.198; Std.
## beta = -0.39, 95% CI [-0.99, 0.21])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-4.94, 10.27], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.25, 95% CI [-0.46, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-5.60, 3.80], t(2038) = -0.38, p = 0.707; Std.
## beta = -0.08, 95% CI [-0.52, 0.35])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.19, 95% CI [2.92, 19.45], t(2038) = 2.65, p = 0.008; Std.
## beta = 1.04, 95% CI [0.27, 1.81])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-2.10, 8.98], t(2038) = 1.22, p = 0.223; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.43, 95% CI [-7.77, 2.92], t(2038) = -0.89, p = 0.373; Std.
## beta = -0.23, 95% CI [-0.72, 0.27])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.22, 95% CI [-6.85, 0.42], t(2038) = -1.74, p = 0.083; Std.
## beta = -0.30, 95% CI [-0.64, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.68, 95% CI [-63.54, -29.82], t(2038) = -5.43, p < .001;
## Std. beta = -4.35, 95% CI [-5.92, -2.78])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.56, 95% CI [-9.45, 8.33], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.05, 95% CI [-0.88, 0.78])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.88, 11.83], t(2038) = 0.18, p = 0.861; Std.
## beta = 0.09, 95% CI [-0.92, 1.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-9.47, 11.69], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.10, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to cohort
## = CARE-PF, is at 58.68 (95% CI [50.82, 66.54], t(2038) = 14.63, p < .001).
## Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.18, 95% CI [-6.32, -0.03], t(2038) = -1.98, p = 0.048; Std. beta = -0.37,
## 95% CI [-0.48, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 0.84, 95% CI [-7.62, 9.29], t(2038) = 0.19, p = 0.846; Std. beta = -0.01, 95%
## CI [-0.15, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-40.53, 25.58], t(2038) = -0.44, p = 0.657; Std. beta = -1.73,
## 95% CI [-4.43, 0.96])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.96, 95% CI [-9.72, 37.64], t(2038) = 1.16, p = 0.248; Std. beta = 0.95,
## 95% CI [-0.45, 2.34])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-19.58, 26.59], t(2038) = 0.30, p = 0.766; Std. beta = -0.24,
## 95% CI [-1.73, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.06, 95% CI [-30.10, 7.98], t(2038) = -1.14, p = 0.255; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.16, 95% CI [-3.26, 43.59], t(2038) = 1.69, p = 0.092; Std. beta = 0.94,
## 95% CI [-0.54, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.07, 95% CI [3.48, 22.65], t(2038) = 2.67, p = 0.008; Std. beta = 0.41, 95%
## CI [-0.16, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-1.27, 45.25], t(2038) = 1.85, p = 0.064; Std. beta = 0.74,
## 95% CI [-0.70, 2.18])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-3.51, 10.79], t(2038) = 1.00, p = 0.319; Std. beta = 0.12, 95%
## CI [-0.32, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.56, 95% CI [-1.45, 24.57], t(2038) = 1.74, p = 0.082; Std. beta = 0.42,
## 95% CI [-0.36, 1.21])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-7.00, 6.10], t(2038) = -0.13, p = 0.893; Std. beta = 0.10,
## 95% CI [-0.31, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-18.47, 8.73], t(2038) = -0.70, p = 0.482; Std. beta = 0.21,
## 95% CI [-0.70, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.99, 95% CI [-1.94, 11.93], t(2038) = 1.41, p = 0.158; Std. beta = 0.23, 95%
## CI [-0.19, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.98, 5.11], t(2038) = -0.79, p = 0.431; Std. beta = -0.05,
## 95% CI [-0.57, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-28.02, 19.09], t(2038) = -0.37, p = 0.710; Std. beta = 0.34,
## 95% CI [-1.21, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-18.54, 20.47], t(2038) = 0.10, p = 0.923; Std. beta = 0.55,
## 95% CI [-0.61, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.60, 95% CI [-19.75, 48.94], t(2038) = 0.83, p = 0.405; Std. beta = 0.86,
## 95% CI [-1.16, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.58, 95% CI [4.36, 36.80], t(2038) = 2.49, p = 0.013; Std. beta = 1.48, 95%
## CI [0.50, 2.47])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.06, 95% CI [-11.25, 35.36], t(2038) = 1.01, p = 0.311; Std. beta = 0.66,
## 95% CI [-0.79, 2.10])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.27, 95% CI [-1.15, 33.70], t(2038) = 1.83, p = 0.067; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-22.19, 36.82], t(2038) = 0.49, p = 0.627; Std. beta = 0.67,
## 95% CI [-1.79, 3.13])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.73, 95% CI [-60.83, 5.37], t(2038) = -1.64, p = 0.101; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.96, 95% CI [-29.66, -0.26], t(2038) = -2.00, p = 0.046; Std. beta = -0.69,
## 95% CI [-1.60, 0.22])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 6.18, 95% CI [-26.91, 39.28], t(2038) = 0.37, p = 0.714; Std. beta = 0.36,
## 95% CI [-1.58, 2.30])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.85, 95% CI [-22.63, 24.33], t(2038) = 0.07, p = 0.943; Std. beta = 0.59,
## 95% CI [-1.45, 2.62])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.51, 95% CI [-3.86, 24.88], t(2038) = 1.43, p = 0.152; Std. beta = 0.48,
## 95% CI [-0.42, 1.39])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-9.78, 17.80], t(2038) = 0.57, p = 0.569; Std. beta = 0.28, 95%
## CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.08, 36.24], t(2038) = 0.25, p = 0.803; Std. beta = 0.62,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-8.92, 11.85], t(2038) = 0.28, p = 0.782; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.21, 95% CI [-25.37, 4.96], t(2038) = -1.32, p = 0.187; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.44, 95% CI [-6.35, 19.22], t(2038) = 0.99, p = 0.323; Std. beta = 0.35, 95%
## CI [-0.43, 1.12])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-11.70, 15.80], t(2038) = 0.29, p = 0.770; Std. beta = -0.46,
## 95% CI [-1.30, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-18.47, 19.93], t(2038) = 0.07, p = 0.940; Std. beta = -0.91,
## 95% CI [-2.89, 1.07])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.33, 95% CI [-36.18, 29.52], t(2038) = -0.20, p = 0.843; Std. beta = -0.28,
## 95% CI [-2.19, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-10.24, 19.14], t(2038) = 0.59, p = 0.553; Std. beta = 0.30,
## 95% CI [-0.56, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.50, 95% CI [-4.23, 29.23], t(2038) = 1.47, p = 0.143; Std. beta = 0.38,
## 95% CI [-0.65, 1.41])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.31, 95% CI [-31.93, 1.31], t(2038) = -1.81, p = 0.071; Std. beta = -0.67,
## 95% CI [-1.76, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.86, 95% CI [-9.98, 15.70], t(2038) = 0.44, p = 0.662; Std. beta = 0.09, 95%
## CI [-0.69, 0.88])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-12.94, 26.00], t(2038) = 0.66, p = 0.511; Std. beta = 1.32,
## 95% CI [0.12, 2.53])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.18, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.44,
## 95% CI [-1.36, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.11, 95% CI [-3.22, 29.44], t(2038) = 1.57, p = 0.116; Std. beta = 0.56,
## 95% CI [-0.41, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.76, 95% CI [1.63, 23.90], t(2038) = 2.25, p = 0.025; Std. beta = 0.48, 95%
## CI [-0.19, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-13.76, 52.12], t(2038) = 1.14, p = 0.254; Std. beta = -2.80,
## 95% CI [-4.92, -0.68])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.46, 95% CI [5.25, 51.66], t(2038) = 2.41, p = 0.016; Std. beta = 1.62, 95%
## CI [0.15, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.55, 95% CI [-19.61, 18.51], t(2038) = -0.06, p = 0.955; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-10.38, 10.19], t(2038) = -0.02, p = 0.986; Std. beta = 0.09,
## 95% CI [-0.83, 1.01])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.15, 95% CI [-4.49, 2.19], t(2038) = -0.68, p = 0.499;
## Std. beta = -0.03, 95% CI [-0.11, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.40, 95% CI [-44.35, 13.54], t(2038) = -1.04, p = 0.297;
## Std. beta = -1.44, 95% CI [-4.13, 1.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-8.33, 11.37], t(2038) = 0.30, p = 0.762; Std.
## beta = 0.14, 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.33, 95% CI [-16.18, 5.52], t(2038) = -0.96, p = 0.335; Std.
## beta = -0.50, 95% CI [-1.51, 0.51])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-13.04, 11.35], t(2038) = -0.14, p = 0.892;
## Std. beta = -0.08, 95% CI [-1.22, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-12.33, 6.45], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.27, 95% CI [-1.15, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.21, 95% CI [-7.09, -1.32], t(2038) = -2.86, p = 0.004; Std.
## beta = -0.39, 95% CI [-0.66, -0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.50, 95% CI [-14.79, 1.80], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.61, 95% CI [-1.38, 0.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-3.60, 1.31], t(2038) = -0.91, p = 0.362; Std.
## beta = -0.11, 95% CI [-0.34, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.37, 1.31], t(2038) = -1.37, p = 0.171; Std.
## beta = -0.28, 95% CI [-0.69, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-0.88, 3.84], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.95, 95% CI [-0.96, 12.87], t(2038) = 1.69, p = 0.091; Std.
## beta = 0.56, 95% CI [-0.09, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-3.06, 1.67], t(2038) = -0.58, p = 0.565; Std.
## beta = -0.06, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-1.47, 5.00], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.16, 95% CI [-0.14, 0.47])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.20, 95% CI [-6.00, 20.41], t(2038) = 1.07, p = 0.285; Std.
## beta = 0.67, 95% CI [-0.56, 1.90])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.87, 95% CI [-0.47, 12.20], t(2038) = 1.82, p = 0.070; Std.
## beta = 0.55, 95% CI [-0.04, 1.14])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.11, 8.73], t(2038) = 1.20, p = 0.231; Std.
## beta = 0.31, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.61, 7.46], t(2038) = -0.14, p = 0.889; Std.
## beta = -0.05, 95% CI [-0.80, 0.70])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-10.03, 5.82], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.20, 95% CI [-0.93, 0.54])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-34.29, 40.08], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.27, 95% CI [-3.20, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-24.93, 19.73], t(2038) = -0.23, p = 0.819;
## Std. beta = -0.24, 95% CI [-2.32, 1.84])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-2.89, 7.41], t(2038) = 0.86, p = 0.389; Std.
## beta = 0.21, 95% CI [-0.27, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.39, 95% CI [-14.78, 27.56], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.60, 95% CI [-1.38, 2.57])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.82, 4.62], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.15, 95% CI [-0.73, 0.43])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-5.78, 6.76], t(2038) = 0.15, p = 0.879; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.23, 13.39], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.43, 95% CI [-0.39, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-8.87, 1.59], t(2038) = -1.37, p = 0.172; Std.
## beta = -0.34, 95% CI [-0.83, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-8.82, 10.93], t(2038) = 0.21, p = 0.834; Std.
## beta = 0.10, 95% CI [-0.82, 1.02])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.01, 4.28], t(2038) = -0.15, p = 0.878; Std.
## beta = -0.03, 95% CI [-0.47, 0.40])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.85, 95% CI [-12.31, -1.39], t(2038) = -2.46, p = 0.014;
## Std. beta = -0.64, 95% CI [-1.15, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.35, 95% CI [-32.88, 10.19], t(2038) = -1.03, p = 0.302;
## Std. beta = -1.06, 95% CI [-3.07, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-10.32, 8.31], t(2038) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.96, 0.77])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-3.37, 4.36], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.05, 95% CI [-0.31, 0.41])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.22, 95% CI [-10.66, 2.21], t(2038) = -1.29, p = 0.198; Std.
## beta = -0.39, 95% CI [-0.99, 0.21])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-4.94, 10.27], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.25, 95% CI [-0.46, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-5.60, 3.80], t(2038) = -0.38, p = 0.707; Std.
## beta = -0.08, 95% CI [-0.52, 0.35])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.19, 95% CI [2.92, 19.45], t(2038) = 2.65, p = 0.008; Std.
## beta = 1.04, 95% CI [0.27, 1.81])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-2.10, 8.98], t(2038) = 1.22, p = 0.223; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.43, 95% CI [-7.77, 2.92], t(2038) = -0.89, p = 0.373; Std.
## beta = -0.23, 95% CI [-0.72, 0.27])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.22, 95% CI [-6.85, 0.42], t(2038) = -1.74, p = 0.083; Std.
## beta = -0.30, 95% CI [-0.64, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.68, 95% CI [-63.54, -29.82], t(2038) = -5.43, p < .001;
## Std. beta = -4.35, 95% CI [-5.92, -2.78])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.56, 95% CI [-9.45, 8.33], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.05, 95% CI [-0.88, 0.78])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.88, 11.83], t(2038) = 0.18, p = 0.861; Std.
## beta = 0.09, 95% CI [-0.92, 1.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-9.47, 11.69], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.10, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*BC_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT * disadv +
## time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14180.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2937 -0.4368 -0.0150 0.4476 4.5076
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 231.77 15.224
## time_firstPFT 13.73 3.705 -0.07
## Residual 25.74 5.073
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 28.86321 7.04649 4.096
## time_firstPFT -0.45326 2.75644 -0.164
## BC_5yrPreDx 3.32693 4.16014 0.800
## disadv 4.04099 2.86895 1.409
## dich_RaceNon-White -7.51535 2.79809 -2.686
## sexF 3.51858 1.75151 2.009
## age_dx 0.38880 0.09119 4.264
## smokeHxFormer 3.75821 1.72792 2.175
## smokeHxAlways 19.05741 8.41866 2.264
## smokeHxUnknown -2.26817 3.92179 -0.578
## site02R -10.37395 16.18865 -0.641
## site03R 12.50812 11.69546 1.069
## site04R 3.66085 11.26479 0.325
## site05R -12.34011 9.33396 -1.322
## site06R 10.42009 16.11947 0.646
## site07R 12.50776 4.71559 2.652
## site09R 21.09995 11.39142 1.852
## site101 5.61376 3.55217 1.580
## site102 13.87001 6.42008 2.160
## site103 0.19912 3.34042 0.060
## site104 -5.01878 6.70583 -0.748
## site105 5.71951 3.43779 1.664
## site106 -4.56424 4.26434 -1.070
## site107 -0.96599 11.53698 -0.084
## site108 7.27232 9.98015 0.729
## site10R 12.57346 17.11209 0.735
## site11R 17.17425 7.93633 2.164
## site12R 8.39928 11.38112 0.738
## site13R 18.04866 8.59191 2.101
## site14R 6.82344 14.67691 0.465
## site15R -34.80718 16.21769 -2.146
## site16R -9.15559 7.28156 -1.257
## site17R 11.14937 16.32103 0.683
## site18R -2.62953 11.51516 -0.228
## site19R 10.75785 7.07039 1.522
## site20R 3.22304 6.75922 0.477
## site21R 2.15053 15.65563 0.137
## site22R -2.16472 5.17220 -0.419
## site23R -12.05839 8.91177 -1.353
## site24R 5.82995 6.25055 0.933
## site25R 1.49542 6.80746 0.220
## site28R 3.85426 9.43672 0.408
## site29R -5.11723 16.07597 -0.318
## site31R 6.20572 7.25041 0.856
## site32R 10.57766 8.22610 1.286
## site33R -13.09297 8.15305 -1.606
## site34R 1.17344 6.28234 0.187
## site35R 1.01833 9.54932 0.107
## site36R -11.60624 7.23530 -1.604
## site37R 16.03410 8.07727 1.985
## site38R 12.93701 5.45328 2.372
## site39R 25.81913 16.38853 1.575
## site40R 24.69397 11.34766 2.176
## site41R -2.39173 9.38385 -0.255
## site42R -0.51911 5.10184 -0.102
## time_firstPFT:BC_5yrPreDx -1.17000 1.78074 -0.657
## time_firstPFT:disadv -0.21358 1.10710 -0.193
## time_firstPFT:dich_RaceNon-White 0.22742 1.12547 0.202
## time_firstPFT:sexF -0.02688 0.66991 -0.040
## time_firstPFT:age_dx -0.05332 0.03501 -1.523
## time_firstPFT:smokeHxFormer 0.35519 0.67866 0.523
## time_firstPFT:smokeHxAlways 1.06630 5.32702 0.200
## time_firstPFT:smokeHxUnknown 1.54220 1.69138 0.912
## time_firstPFT:site02R -14.72687 14.80935 -0.994
## time_firstPFT:site03R 2.61802 5.11223 0.512
## time_firstPFT:site04R -4.95205 5.63095 -0.879
## time_firstPFT:site05R -0.53394 6.26834 -0.085
## time_firstPFT:site07R -3.74468 1.53465 -2.440
## time_firstPFT:site09R -6.30117 4.34060 -1.452
## time_firstPFT:site101 -0.96074 1.30073 -0.739
## time_firstPFT:site102 -3.10454 2.27253 -1.366
## time_firstPFT:site103 1.67612 1.29598 1.293
## time_firstPFT:site104 6.45031 3.64004 1.772
## time_firstPFT:site105 -0.60839 1.24411 -0.489
## time_firstPFT:site106 2.32380 1.72230 1.349
## time_firstPFT:site107 7.28371 6.78199 1.074
## time_firstPFT:site108 5.84659 3.51367 1.664
## time_firstPFT:site11R 4.14151 2.86688 1.445
## time_firstPFT:site12R -0.12816 4.20744 -0.030
## time_firstPFT:site13R -1.66421 4.13428 -0.403
## time_firstPFT:site14R 3.29143 19.00191 0.173
## time_firstPFT:site15R -2.20895 11.44301 -0.193
## time_firstPFT:site16R 2.01518 2.73708 0.736
## time_firstPFT:site18R 6.98737 10.84342 0.644
## time_firstPFT:site19R -0.79503 3.26504 -0.243
## time_firstPFT:site20R 1.17860 3.28655 0.359
## time_firstPFT:site21R 4.82685 4.58920 1.052
## time_firstPFT:site22R -2.77252 2.74747 -1.009
## time_firstPFT:site23R 8.97727 24.73997 0.363
## time_firstPFT:site24R -0.23706 2.41385 -0.098
## time_firstPFT:site25R -6.19530 2.88155 -2.150
## time_firstPFT:site28R -9.76781 11.10859 -0.879
## time_firstPFT:site29R -0.44082 4.86705 -0.091
## time_firstPFT:site31R 0.59671 2.06099 0.290
## time_firstPFT:site32R -3.57289 3.37055 -1.060
## time_firstPFT:site33R 3.20331 4.01870 0.797
## time_firstPFT:site34R -0.63765 2.47289 -0.258
## time_firstPFT:site35R 12.11361 4.31176 2.809
## time_firstPFT:site36R 3.75557 2.89781 1.296
## time_firstPFT:site37R -1.86338 2.86974 -0.649
## time_firstPFT:site38R -2.95292 1.89968 -1.554
## time_firstPFT:site39R -47.10592 8.75185 -5.382
## time_firstPFT:site40R 0.53585 4.69116 0.114
## time_firstPFT:site41R 1.73406 5.59506 0.310
## time_firstPFT:site42R 2.00758 5.41783 0.371##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.917
## Unadjusted ICC: 0.691report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## BC_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 28.86 (95% CI [15.04, 42.68], t(2008)
## = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## BC_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to BC_5yrPreDx = 0, is at 28.86 (95% CI
## [15.04, 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 28.86 (95% CI [15.04,
## 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to dich_Race = White, is at 28.86 (95% CI
## [15.04, 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 28.86 (95% CI [15.04,
## 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 28.86 (95% CI [15.04,
## 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 28.86 (95% CI
## [15.04, 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 28.86 (95% CI [15.04,
## 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to cohort = CARE-PF, is at 28.86 (95% CI
## [15.04, 42.68], t(2008) = 4.10, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.45, 95% CI [-5.86, 4.95], t(2008) = -0.16, p = 0.869; Std. beta =
## -0.42, 95% CI [-0.58, -0.27])
## - The effect of BC 5yrPreDx is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.83, 11.49], t(2008) = 0.80, p = 0.424; Std. beta = 0.02, 95%
## CI [-0.11, 0.16])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.04, 95% CI [-1.59, 9.67], t(2008) = 1.41, p = 0.159; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.52, 95% CI [-13.00, -2.03], t(2008) = -2.69, p = 0.007; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.52,
## 95% CI [0.08, 6.95], t(2008) = 2.01, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.76, 95% CI [0.37, 7.15], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.46])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.06, 95% CI [2.55, 35.57], t(2008) = 2.26, p = 0.024; Std. beta =
## 1.21, 95% CI [0.03, 2.38])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.27, 95% CI [-9.96, 5.42], t(2008) = -0.58, p = 0.563; Std. beta =
## -2.79e-03, 95% CI [-0.50, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.37, 95% CI [-42.12, 21.37], t(2008) = -0.64, p = 0.522; Std. beta =
## -1.85, 95% CI [-4.52, 0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.51, 95% CI [-10.43, 35.44], t(2008) = 1.07, p = 0.285; Std. beta = 0.95,
## 95% CI [-0.42, 2.33])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-18.43, 25.75], t(2008) = 0.32, p = 0.745; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.65, 5.97], t(2008) = -1.32, p = 0.186; Std. beta = -0.77,
## 95% CI [-2.09, 0.55])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-21.19, 42.03], t(2008) = 0.65, p = 0.518; Std. beta = 0.61,
## 95% CI [-1.24, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.51, 95% CI [3.26, 21.76], t(2008) = 2.65, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.15, 0.98])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.10, 95% CI [-1.24, 43.44], t(2008) = 1.85, p = 0.064; Std. beta = 0.71,
## 95% CI [-0.71, 2.12])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.61, 95% CI [-1.35, 12.58], t(2008) = 1.58, p = 0.114; Std. beta = 0.25, 95%
## CI [-0.19, 0.68])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.87, 95% CI [1.28, 26.46], t(2008) = 2.16, p = 0.031; Std. beta = 0.55, 95%
## CI [-0.22, 1.32])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-6.35, 6.75], t(2008) = 0.06, p = 0.952; Std. beta = 0.15, 95%
## CI [-0.26, 0.57])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-18.17, 8.13], t(2008) = -0.75, p = 0.454; Std. beta = 0.25,
## 95% CI [-0.66, 1.16])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.72, 95% CI [-1.02, 12.46], t(2008) = 1.66, p = 0.096; Std. beta = 0.28, 95%
## CI [-0.13, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-12.93, 3.80], t(2008) = -1.07, p = 0.285; Std. beta = -0.07,
## 95% CI [-0.59, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.97, 95% CI [-23.59, 21.66], t(2008) = -0.08, p = 0.933; Std. beta = 0.56,
## 95% CI [-0.97, 2.08])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 7.27, 95% CI [-12.30, 26.84], t(2008) = 0.73, p = 0.466; Std. beta = 0.92,
## 95% CI [-0.27, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.57, 95% CI [-20.99, 46.13], t(2008) = 0.73, p = 0.463; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.17, 95% CI [1.61, 32.74], t(2008) = 2.16, p = 0.031; Std. beta = 1.36, 95%
## CI [0.39, 2.32])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 8.40, 95% CI [-13.92, 30.72], t(2008) = 0.74, p = 0.461; Std. beta = 0.48,
## 95% CI [-0.93, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.05, 95% CI [1.20, 34.90], t(2008) = 2.10, p = 0.036; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.82, 95% CI [-21.96, 35.61], t(2008) = 0.46, p = 0.642; Std. beta = 0.68,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.81, 95% CI [-66.61, -3.00], t(2008) = -2.15, p = 0.032; Std. beta = -2.23,
## 95% CI [-4.51, 0.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.16, 95% CI [-23.44, 5.12], t(2008) = -1.26, p = 0.209; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 11.15, 95% CI [-20.86, 43.16], t(2008) = 0.68, p = 0.495; Std. beta = 0.65,
## 95% CI [-1.22, 2.53])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-25.21, 19.95], t(2008) = -0.23, p = 0.819; Std. beta = 0.44,
## 95% CI [-1.59, 2.46])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-3.11, 24.62], t(2008) = 1.52, p = 0.128; Std. beta = 0.56,
## 95% CI [-0.33, 1.46])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.03, 16.48], t(2008) = 0.48, p = 0.634; Std. beta = 0.29,
## 95% CI [-0.58, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.15, 95% CI [-28.55, 32.85], t(2008) = 0.14, p = 0.891; Std. beta = 0.53,
## 95% CI [-1.30, 2.37])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-12.31, 7.98], t(2008) = -0.42, p = 0.676; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.06, 95% CI [-29.54, 5.42], t(2008) = -1.35, p = 0.176; Std. beta = 0.05,
## 95% CI [-3.77, 3.88])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-6.43, 18.09], t(2008) = 0.93, p = 0.351; Std. beta = 0.32, 95%
## CI [-0.44, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-11.86, 14.85], t(2008) = 0.22, p = 0.826; Std. beta = -0.44,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-14.65, 22.36], t(2008) = 0.41, p = 0.683; Std. beta = -0.60,
## 95% CI [-2.59, 1.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.12, 95% CI [-36.64, 26.41], t(2008) = -0.32, p = 0.750; Std. beta = -0.34,
## 95% CI [-2.20, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-8.01, 20.42], t(2008) = 0.86, p = 0.392; Std. beta = 0.41, 95%
## CI [-0.44, 1.27])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.58, 95% CI [-5.55, 26.71], t(2008) = 1.29, p = 0.199; Std. beta = 0.32,
## 95% CI [-0.70, 1.33])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-29.08, 2.90], t(2008) = -1.61, p = 0.108; Std. beta = -0.50,
## 95% CI [-1.57, 0.58])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-11.15, 13.49], t(2008) = 0.19, p = 0.852; Std. beta = 0.01,
## 95% CI [-0.75, 0.78])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-17.71, 19.75], t(2008) = 0.11, p = 0.915; Std. beta = 1.08,
## 95% CI [-0.10, 2.27])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.61, 95% CI [-25.80, 2.58], t(2008) = -1.60, p = 0.109; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.03, 95% CI [0.19, 31.87], t(2008) = 1.99, p = 0.047; Std. beta = 0.78, 95%
## CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.94, 95% CI [2.24, 23.63], t(2008) = 2.37, p = 0.018; Std. beta = 0.51, 95%
## CI [-0.15, 1.16])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 25.82, 95% CI [-6.32, 57.96], t(2008) = 1.58, p = 0.115; Std. beta = -2.46,
## 95% CI [-4.58, -0.35])
## - The effect of site [40R] is statistically significant and positive (beta =
## 24.69, 95% CI [2.44, 46.95], t(2008) = 2.18, p = 0.030; Std. beta = 1.49, 95%
## CI [0.05, 2.94])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-20.79, 16.01], t(2008) = -0.25, p = 0.799; Std. beta =
## 6.16e-03, 95% CI [-1.26, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-10.52, 9.49], t(2008) = -0.10, p = 0.919; Std. beta = 0.14,
## 95% CI [-0.78, 1.06])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and negative (beta = -1.17, 95% CI [-4.66, 2.32], t(2008) = -0.66, p = 0.511;
## Std. beta = -0.03, 95% CI [-0.11, 0.06])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.38, 1.96], t(2008) = -0.19, p = 0.847; Std.
## beta = -5.72e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.23, 95% CI [-1.98, 2.43], t(2008) =
## 0.20, p = 0.840; Std. beta = 0.02, 95% CI [-0.18, 0.23])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-1.34, 1.29], t(2008) = -0.04, p = 0.968; Std.
## beta = -2.51e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.52, p = 0.128; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.36, 95% CI [-0.98, 1.69], t(2008) =
## 0.52, p = 0.601; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.07, 95% CI [-9.38, 11.51], t(2008) =
## 0.20, p = 0.841; Std. beta = 0.10, 95% CI [-0.88, 1.08])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.54, 95% CI [-1.77, 4.86], t(2008) =
## 0.91, p = 0.362; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.77, 14.32], t(2008) = -0.99, p = 0.320;
## Std. beta = -1.38, 95% CI [-4.09, 1.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.62, 95% CI [-7.41, 12.64], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.24, 95% CI [-0.69, 1.18])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.95, 95% CI [-16.00, 6.09], t(2008) = -0.88, p = 0.379; Std.
## beta = -0.46, 95% CI [-1.49, 0.57])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-12.83, 11.76], t(2008) = -0.09, p = 0.932;
## Std. beta = -0.05, 95% CI [-1.20, 1.10])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.74, 95% CI [-6.75, -0.74], t(2008) = -2.44, p = 0.015; Std.
## beta = -0.35, 95% CI [-0.63, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.30, 95% CI [-14.81, 2.21], t(2008) = -1.45, p = 0.147; Std.
## beta = -0.59, 95% CI [-1.38, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.51, 1.59], t(2008) = -0.74, p = 0.460; Std.
## beta = -0.09, 95% CI [-0.33, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.56, 1.35], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.29, 95% CI [-0.71, 0.13])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-0.87, 4.22], t(2008) = 1.29, p = 0.196; Std.
## beta = 0.16, 95% CI [-0.08, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.45, 95% CI [-0.69, 13.59], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.60, 95% CI [-0.06, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.05, 1.83], t(2008) = -0.49, p = 0.625; Std.
## beta = -0.06, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-1.05, 5.70], t(2008) = 1.35, p = 0.177; Std.
## beta = 0.22, 95% CI [-0.10, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.28, 95% CI [-6.02, 20.58], t(2008) = 1.07, p = 0.283; Std.
## beta = 0.68, 95% CI [-0.56, 1.92])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.04, 12.74], t(2008) = 1.66, p = 0.096; Std.
## beta = 0.55, 95% CI [-0.10, 1.19])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.14, 95% CI [-1.48, 9.76], t(2008) = 1.44, p = 0.149; Std.
## beta = 0.39, 95% CI [-0.14, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.38, 8.12], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.78, 0.76])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-9.77, 6.44], t(2008) = -0.40, p = 0.687; Std.
## beta = -0.16, 95% CI [-0.91, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.29, 95% CI [-33.97, 40.56], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.21, 95% CI [-24.65, 20.23], t(2008) = -0.19, p = 0.847;
## Std. beta = -0.21, 95% CI [-2.30, 1.89])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-3.35, 7.38], t(2008) = 0.74, p = 0.462; Std.
## beta = 0.19, 95% CI [-0.31, 0.69])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.99, 95% CI [-14.28, 28.25], t(2008) = 0.64, p = 0.519; Std.
## beta = 0.65, 95% CI [-1.33, 2.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-7.20, 5.61], t(2008) = -0.24, p = 0.808; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-5.27, 7.62], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.11, 95% CI [-0.49, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-4.17, 13.83], t(2008) = 1.05, p = 0.293; Std.
## beta = 0.45, 95% CI [-0.39, 1.29])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-8.16, 2.62], t(2008) = -1.01, p = 0.313; Std.
## beta = -0.26, 95% CI [-0.76, 0.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.98, 95% CI [-39.54, 57.50], t(2008) = 0.36, p = 0.717; Std.
## beta = 0.84, 95% CI [-3.69, 5.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-4.97, 4.50], t(2008) = -0.10, p = 0.922; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.20, 95% CI [-11.85, -0.54], t(2008) = -2.15, p = 0.032;
## Std. beta = -0.58, 95% CI [-1.11, -0.05])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.55, 12.02], t(2008) = -0.88, p = 0.379;
## Std. beta = -0.91, 95% CI [-2.95, 1.12])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.44, 95% CI [-9.99, 9.10], t(2008) = -0.09, p = 0.928; Std.
## beta = -0.04, 95% CI [-0.93, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-3.45, 4.64], t(2008) = 0.29, p = 0.772; Std.
## beta = 0.06, 95% CI [-0.32, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-10.18, 3.04], t(2008) = -1.06, p = 0.289; Std.
## beta = -0.33, 95% CI [-0.95, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.20, 95% CI [-4.68, 11.08], t(2008) = 0.80, p = 0.425; Std.
## beta = 0.30, 95% CI [-0.44, 1.04])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-5.49, 4.21], t(2008) = -0.26, p = 0.797; Std.
## beta = -0.06, 95% CI [-0.51, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.11, 95% CI [3.66, 20.57], t(2008) = 2.81, p = 0.005; Std.
## beta = 1.13, 95% CI [0.34, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.76, 95% CI [-1.93, 9.44], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.49, 3.76], t(2008) = -0.65, p = 0.516; Std.
## beta = -0.17, 95% CI [-0.70, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-6.68, 0.77], t(2008) = -1.55, p = 0.120; Std.
## beta = -0.28, 95% CI [-0.62, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.11, 95% CI [-64.27, -29.94], t(2008) = -5.38, p < .001;
## Std. beta = -4.40, 95% CI [-6.01, -2.80])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-8.66, 9.74], t(2008) = 0.11, p = 0.909; Std.
## beta = 0.05, 95% CI [-0.81, 0.91])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-9.24, 12.71], t(2008) = 0.31, p = 0.757; Std.
## beta = 0.16, 95% CI [-0.86, 1.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.62, 12.63], t(2008) = 0.37, p = 0.711; Std.
## beta = 0.19, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*OM_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14379.9
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3110 -0.4400 -0.0164 0.4473 4.5288
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 255.89 15.997
## time_firstPFT 13.00 3.605 -0.11
## Residual 25.71 5.071
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 60.52332 2.97151 20.368
## time_firstPFT -4.29685 1.05916 -4.057
## OM_5yrPreDx -0.32458 0.78280 -0.415
## site02R -7.81678 16.80419 -0.465
## site03R 13.91951 12.05532 1.155
## site04R 3.10283 11.75496 0.264
## site05R -11.21048 9.70660 -1.155
## site06R 20.69373 11.99618 1.725
## site07R 12.55903 4.77246 2.632
## site09R 21.58589 11.82489 1.825
## site101 3.02604 3.29440 0.919
## site102 11.04855 6.34024 1.743
## site103 -0.96284 2.75242 -0.350
## site104 -5.78875 6.52915 -0.887
## site105 4.77663 3.16205 1.511
## site106 -3.80342 4.18724 -0.908
## site107 -4.86489 11.89986 -0.409
## site108 0.02893 9.61720 0.003
## site10R 14.64980 17.45792 0.839
## site11R 20.79094 8.27784 2.512
## site12R 11.32488 11.82431 0.958
## site13R 15.90109 8.86115 1.794
## site14R 6.63924 15.02419 0.442
## site15R -27.28478 16.83845 -1.620
## site16R -15.03552 7.48915 -2.008
## site17R 5.80535 16.83700 0.345
## site18R 0.49651 11.93053 0.042
## site19R 9.37874 7.10607 1.320
## site20R 3.49274 6.97166 0.501
## site21R 4.31288 16.38243 0.263
## site22R 1.06230 5.30990 0.200
## site23R -10.69836 7.62183 -1.404
## site24R 5.90953 6.40631 0.922
## site25R 1.79346 6.93309 0.259
## site28R 0.94807 9.77465 0.097
## site29R -4.15066 16.70998 -0.248
## site31R 4.03660 7.44981 0.542
## site32R 11.84241 8.44133 1.403
## site33R -15.89367 8.39643 -1.893
## site34R 2.26090 6.41576 0.352
## site35R 5.76453 9.77525 0.590
## site36R -12.19872 7.52387 -1.621
## site37R 12.88484 8.31659 1.549
## site38R 12.52991 5.64182 2.221
## site39R 18.20748 16.70159 1.090
## site40R 28.92343 11.76857 2.458
## site41R -0.86285 9.68193 -0.089
## site42R -0.44372 5.22605 -0.085
## time_firstPFT:OM_5yrPreDx 0.02330 0.27762 0.084
## time_firstPFT:site02R -15.04430 14.75309 -1.020
## time_firstPFT:site03R 1.66499 5.02202 0.332
## time_firstPFT:site04R -5.01191 5.52017 -0.908
## time_firstPFT:site05R -0.78482 6.22084 -0.126
## time_firstPFT:site06R -3.03315 4.80912 -0.631
## time_firstPFT:site07R -3.83737 1.39377 -2.753
## time_firstPFT:site09R -6.32935 4.22329 -1.499
## time_firstPFT:site101 -0.66791 1.07743 -0.620
## time_firstPFT:site102 -2.51439 2.07958 -1.209
## time_firstPFT:site103 1.98850 0.94937 2.095
## time_firstPFT:site104 6.48914 3.44869 1.882
## time_firstPFT:site105 -0.30017 1.06011 -0.283
## time_firstPFT:site106 2.12286 1.57352 1.349
## time_firstPFT:site107 7.68841 6.69891 1.148
## time_firstPFT:site108 6.64282 3.05832 2.172
## time_firstPFT:site11R 3.25360 2.76764 1.176
## time_firstPFT:site12R -0.25919 4.08095 -0.064
## time_firstPFT:site13R -1.80109 4.02273 -0.448
## time_firstPFT:site14R 3.24226 18.96370 0.171
## time_firstPFT:site15R -2.89533 11.38126 -0.254
## time_firstPFT:site16R 2.42885 2.62298 0.926
## time_firstPFT:site18R 6.66482 10.79115 0.618
## time_firstPFT:site19R -0.92448 3.07757 -0.300
## time_firstPFT:site20R 0.89882 3.16006 0.284
## time_firstPFT:site21R 4.45164 4.48742 0.992
## time_firstPFT:site22R -3.44575 2.66858 -1.291
## time_firstPFT:site23R 1.47383 5.00463 0.294
## time_firstPFT:site24R 0.04327 2.30999 0.019
## time_firstPFT:site25R -6.39290 2.70856 -2.360
## time_firstPFT:site28R -11.31710 10.98419 -1.030
## time_firstPFT:site29R -0.51017 4.71965 -0.108
## time_firstPFT:site31R 0.78195 1.93975 0.403
## time_firstPFT:site32R -3.96857 3.26615 -1.215
## time_firstPFT:site33R 3.13916 3.84445 0.817
## time_firstPFT:site34R -0.48387 2.33104 -0.208
## time_firstPFT:site35R 11.81784 4.13894 2.855
## time_firstPFT:site36R 3.33321 2.82501 1.180
## time_firstPFT:site37R -2.32069 2.72131 -0.853
## time_firstPFT:site38R -3.00597 1.83000 -1.643
## time_firstPFT:site39R -46.03174 8.56418 -5.375
## time_firstPFT:site40R 0.06103 4.46903 0.014
## time_firstPFT:site41R 1.22814 5.52630 0.222
## time_firstPFT:site42R 1.29629 5.39434 0.240##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.739report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## OM_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 60.52 (95% CI [54.70,
## 66.35], t(2038) = 20.37, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.30, 95% CI [-6.37, -2.22], t(2038) = -4.06, p < .001; Std. beta = -0.39, 95%
## CI [-0.48, -0.31])
## - The effect of OM 5yrPreDx is statistically non-significant and negative (beta
## = -0.32, 95% CI [-1.86, 1.21], t(2038) = -0.41, p = 0.678; Std. beta = -0.02,
## 95% CI [-0.12, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.82, 95% CI [-40.77, 25.14], t(2038) = -0.47, p = 0.642; Std. beta = -1.72,
## 95% CI [-4.41, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.92, 95% CI [-9.72, 37.56], t(2038) = 1.15, p = 0.248; Std. beta = 0.96,
## 95% CI [-0.44, 2.35])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-19.95, 26.16], t(2038) = 0.26, p = 0.792; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-30.25, 7.83], t(2038) = -1.15, p = 0.248; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.83, 44.22], t(2038) = 1.73, p = 0.085; Std. beta = 0.96,
## 95% CI [-0.52, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.56, 95% CI [3.20, 21.92], t(2038) = 2.63, p = 0.009; Std. beta = 0.41, 95%
## CI [-0.14, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.59, 95% CI [-1.60, 44.78], t(2038) = 1.83, p = 0.068; Std. beta = 0.73,
## 95% CI [-0.71, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.43, 9.49], t(2038) = 0.92, p = 0.358; Std. beta = 0.12, 95%
## CI [-0.27, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.05, 95% CI [-1.39, 23.48], t(2038) = 1.74, p = 0.082; Std. beta = 0.44,
## 95% CI [-0.31, 1.18])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-6.36, 4.44], t(2038) = -0.35, p = 0.727; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.59, 7.02], t(2038) = -0.89, p = 0.375; Std. beta = 0.21,
## 95% CI [-0.66, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.42, 10.98], t(2038) = 1.51, p = 0.131; Std. beta = 0.25, 95%
## CI [-0.12, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.80, 95% CI [-12.02, 4.41], t(2038) = -0.91, p = 0.364; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.86, 95% CI [-28.20, 18.47], t(2038) = -0.41, p = 0.683; Std. beta = 0.36,
## 95% CI [-1.18, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.83, 18.89], t(2038) = 3.01e-03, p = 0.998; Std. beta =
## 0.56, 95% CI [-0.56, 1.68])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.65, 95% CI [-19.59, 48.89], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.15, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.79, 95% CI [4.56, 37.02], t(2038) = 2.51, p = 0.012; Std. beta = 1.49, 95%
## CI [0.50, 2.48])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.32, 95% CI [-11.86, 34.51], t(2038) = 0.96, p = 0.338; Std. beta = 0.64,
## 95% CI [-0.80, 2.08])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.90, 95% CI [-1.48, 33.28], t(2038) = 1.79, p = 0.073; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.64, 95% CI [-22.83, 36.10], t(2038) = 0.44, p = 0.659; Std. beta = 0.66,
## 95% CI [-1.80, 3.12])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.28, 95% CI [-60.31, 5.74], t(2038) = -1.62, p = 0.105; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.04, 95% CI [-29.72, -0.35], t(2038) = -2.01, p = 0.045; Std. beta = -0.68,
## 95% CI [-1.59, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.81, 95% CI [-27.21, 38.82], t(2038) = 0.34, p = 0.730; Std. beta = 0.34,
## 95% CI [-1.60, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.90, 23.89], t(2038) = 0.04, p = 0.967; Std. beta = 0.59,
## 95% CI [-1.45, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.38, 95% CI [-4.56, 23.31], t(2038) = 1.32, p = 0.187; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-10.18, 17.17], t(2038) = 0.50, p = 0.616; Std. beta = 0.28,
## 95% CI [-0.59, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-27.82, 36.44], t(2038) = 0.26, p = 0.792; Std. beta = 0.63,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-9.35, 11.48], t(2038) = 0.20, p = 0.841; Std. beta = -0.23,
## 95% CI [-0.90, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.70, 95% CI [-25.65, 4.25], t(2038) = -1.40, p = 0.161; Std. beta = -0.50,
## 95% CI [-1.61, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.91, 95% CI [-6.65, 18.47], t(2038) = 0.92, p = 0.356; Std. beta = 0.35, 95%
## CI [-0.41, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.79, 95% CI [-11.80, 15.39], t(2038) = 0.26, p = 0.796; Std. beta = -0.43,
## 95% CI [-1.26, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.22, 20.12], t(2038) = 0.10, p = 0.923; Std. beta = -0.90,
## 95% CI [-2.88, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.15, 95% CI [-36.92, 28.62], t(2038) = -0.25, p = 0.804; Std. beta = -0.29,
## 95% CI [-2.19, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.04, 95% CI [-10.57, 18.65], t(2038) = 0.54, p = 0.588; Std. beta = 0.30,
## 95% CI [-0.56, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-4.71, 28.40], t(2038) = 1.40, p = 0.161; Std. beta = 0.36,
## 95% CI [-0.66, 1.38])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.89, 95% CI [-32.36, 0.57], t(2038) = -1.89, p = 0.059; Std. beta = -0.67,
## 95% CI [-1.75, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.32, 14.84], t(2038) = 0.35, p = 0.725; Std. beta = 0.09,
## 95% CI [-0.68, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-13.41, 24.94], t(2038) = 0.59, p = 0.555; Std. beta = 1.33,
## 95% CI [0.14, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-26.95, 2.56], t(2038) = -1.62, p = 0.105; Std. beta = -0.43,
## 95% CI [-1.36, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.88, 95% CI [-3.43, 29.19], t(2038) = 1.55, p = 0.121; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.53, 95% CI [1.47, 23.59], t(2038) = 2.22, p = 0.026; Std. beta = 0.48, 95%
## CI [-0.18, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.21, 95% CI [-14.55, 50.96], t(2038) = 1.09, p = 0.276; Std. beta = -2.80,
## 95% CI [-4.92, -0.69])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.92, 95% CI [5.84, 52.00], t(2038) = 2.46, p = 0.014; Std. beta = 1.70, 95%
## CI [0.24, 3.16])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-19.85, 18.12], t(2038) = -0.09, p = 0.929; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.44, 95% CI [-10.69, 9.81], t(2038) = -0.08, p = 0.932; Std. beta = 0.08,
## 95% CI [-0.84, 1.00])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.02, 95% CI [-0.52, 0.57], t(2038) = 0.08, p = 0.933;
## Std. beta = 2.42e-03, 95% CI [-0.05, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.04, 95% CI [-43.98, 13.89], t(2038) = -1.02, p = 0.308;
## Std. beta = -1.40, 95% CI [-4.10, 1.29])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.18, 11.51], t(2038) = 0.33, p = 0.740; Std.
## beta = 0.16, 95% CI [-0.76, 1.07])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.01, 95% CI [-15.84, 5.81], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.47, 95% CI [-1.48, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.13, p = 0.900;
## Std. beta = -0.07, 95% CI [-1.21, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-12.46, 6.40], t(2038) = -0.63, p = 0.528; Std.
## beta = -0.28, 95% CI [-1.16, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.84, 95% CI [-6.57, -1.10], t(2038) = -2.75, p = 0.006; Std.
## beta = -0.36, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.33, 95% CI [-14.61, 1.95], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.59, 95% CI [-1.36, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-2.78, 1.45], t(2038) = -0.62, p = 0.535; Std.
## beta = -0.06, 95% CI [-0.26, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-6.59, 1.56], t(2038) = -1.21, p = 0.227; Std.
## beta = -0.23, 95% CI [-0.61, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.99, 95% CI [0.13, 3.85], t(2038) = 2.09, p = 0.036; Std.
## beta = 0.19, 95% CI [0.01, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.49, 95% CI [-0.27, 13.25], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.61, 95% CI [-0.03, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-2.38, 1.78], t(2038) = -0.28, p = 0.777; Std.
## beta = -0.03, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-0.96, 5.21], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.20, 95% CI [-0.09, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.69, 95% CI [-5.45, 20.83], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.72, 95% CI [-0.51, 1.94])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.64, 95% CI [0.65, 12.64], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.62, 95% CI [0.06, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-2.17, 8.68], t(2038) = 1.18, p = 0.240; Std.
## beta = 0.30, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.26, 7.74], t(2038) = -0.06, p = 0.949; Std.
## beta = -0.02, 95% CI [-0.77, 0.72])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-9.69, 6.09], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.17, 95% CI [-0.90, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-33.95, 40.43], t(2038) = 0.17, p = 0.864; Std.
## beta = 0.30, 95% CI [-3.17, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.22, 19.42], t(2038) = -0.25, p = 0.799;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.72, 7.57], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.23, 95% CI [-0.25, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-14.50, 27.83], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.62, 95% CI [-1.35, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-6.96, 5.11], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.30, 7.10], t(2038) = 0.28, p = 0.776; Std.
## beta = 0.08, 95% CI [-0.49, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.35, 13.25], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.42, 95% CI [-0.41, 1.24])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.45, 95% CI [-8.68, 1.79], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.32, 95% CI [-0.81, 0.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-8.34, 11.29], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.14, 95% CI [-0.78, 1.05])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.49, 4.57], t(2038) = 0.02, p = 0.985; Std.
## beta = 4.04e-03, 95% CI [-0.42, 0.43])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.39, 95% CI [-11.70, -1.08], t(2038) = -2.36, p = 0.018;
## Std. beta = -0.60, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.32, 95% CI [-32.86, 10.22], t(2038) = -1.03, p = 0.303;
## Std. beta = -1.06, 95% CI [-3.06, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.51, 95% CI [-9.77, 8.75], t(2038) = -0.11, p = 0.914; Std.
## beta = -0.05, 95% CI [-0.91, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-3.02, 4.59], t(2038) = 0.40, p = 0.687; Std.
## beta = 0.07, 95% CI [-0.28, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.97, 95% CI [-10.37, 2.44], t(2038) = -1.22, p = 0.224; Std.
## beta = -0.37, 95% CI [-0.97, 0.23])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-4.40, 10.68], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.29, 95% CI [-0.41, 1.00])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-5.06, 4.09], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.05, 95% CI [-0.47, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.82, 95% CI [3.70, 19.93], t(2038) = 2.86, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.86])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.21, 8.87], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-7.66, 3.02], t(2038) = -0.85, p = 0.394; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.59, 0.58], t(2038) = -1.64, p = 0.101; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.03, 95% CI [-62.83, -29.24], t(2038) = -5.37, p < .001;
## Std. beta = -4.29, 95% CI [-5.86, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-8.70, 8.83], t(2038) = 0.01, p = 0.989; Std.
## beta = 5.69e-03, 95% CI [-0.81, 0.82])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-9.61, 12.07], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.11, 95% CI [-0.90, 1.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-9.28, 11.88], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.12, 95% CI [-0.87, 1.11])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## OM_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to
## OM_5yrPreDx = 0, is at 60.52 (95% CI [54.70, 66.35], t(2038) = 20.37, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.30, 95% CI [-6.37, -2.22], t(2038) = -4.06, p < .001; Std. beta = -0.39, 95%
## CI [-0.48, -0.31])
## - The effect of OM 5yrPreDx is statistically non-significant and negative (beta
## = -0.32, 95% CI [-1.86, 1.21], t(2038) = -0.41, p = 0.678; Std. beta = -0.02,
## 95% CI [-0.12, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.82, 95% CI [-40.77, 25.14], t(2038) = -0.47, p = 0.642; Std. beta = -1.72,
## 95% CI [-4.41, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.92, 95% CI [-9.72, 37.56], t(2038) = 1.15, p = 0.248; Std. beta = 0.96,
## 95% CI [-0.44, 2.35])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-19.95, 26.16], t(2038) = 0.26, p = 0.792; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-30.25, 7.83], t(2038) = -1.15, p = 0.248; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.83, 44.22], t(2038) = 1.73, p = 0.085; Std. beta = 0.96,
## 95% CI [-0.52, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.56, 95% CI [3.20, 21.92], t(2038) = 2.63, p = 0.009; Std. beta = 0.41, 95%
## CI [-0.14, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.59, 95% CI [-1.60, 44.78], t(2038) = 1.83, p = 0.068; Std. beta = 0.73,
## 95% CI [-0.71, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.43, 9.49], t(2038) = 0.92, p = 0.358; Std. beta = 0.12, 95%
## CI [-0.27, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.05, 95% CI [-1.39, 23.48], t(2038) = 1.74, p = 0.082; Std. beta = 0.44,
## 95% CI [-0.31, 1.18])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-6.36, 4.44], t(2038) = -0.35, p = 0.727; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.59, 7.02], t(2038) = -0.89, p = 0.375; Std. beta = 0.21,
## 95% CI [-0.66, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.42, 10.98], t(2038) = 1.51, p = 0.131; Std. beta = 0.25, 95%
## CI [-0.12, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.80, 95% CI [-12.02, 4.41], t(2038) = -0.91, p = 0.364; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.86, 95% CI [-28.20, 18.47], t(2038) = -0.41, p = 0.683; Std. beta = 0.36,
## 95% CI [-1.18, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.83, 18.89], t(2038) = 3.01e-03, p = 0.998; Std. beta =
## 0.56, 95% CI [-0.56, 1.68])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.65, 95% CI [-19.59, 48.89], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.15, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.79, 95% CI [4.56, 37.02], t(2038) = 2.51, p = 0.012; Std. beta = 1.49, 95%
## CI [0.50, 2.48])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.32, 95% CI [-11.86, 34.51], t(2038) = 0.96, p = 0.338; Std. beta = 0.64,
## 95% CI [-0.80, 2.08])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.90, 95% CI [-1.48, 33.28], t(2038) = 1.79, p = 0.073; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.64, 95% CI [-22.83, 36.10], t(2038) = 0.44, p = 0.659; Std. beta = 0.66,
## 95% CI [-1.80, 3.12])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.28, 95% CI [-60.31, 5.74], t(2038) = -1.62, p = 0.105; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.04, 95% CI [-29.72, -0.35], t(2038) = -2.01, p = 0.045; Std. beta = -0.68,
## 95% CI [-1.59, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.81, 95% CI [-27.21, 38.82], t(2038) = 0.34, p = 0.730; Std. beta = 0.34,
## 95% CI [-1.60, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.90, 23.89], t(2038) = 0.04, p = 0.967; Std. beta = 0.59,
## 95% CI [-1.45, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.38, 95% CI [-4.56, 23.31], t(2038) = 1.32, p = 0.187; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-10.18, 17.17], t(2038) = 0.50, p = 0.616; Std. beta = 0.28,
## 95% CI [-0.59, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-27.82, 36.44], t(2038) = 0.26, p = 0.792; Std. beta = 0.63,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-9.35, 11.48], t(2038) = 0.20, p = 0.841; Std. beta = -0.23,
## 95% CI [-0.90, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.70, 95% CI [-25.65, 4.25], t(2038) = -1.40, p = 0.161; Std. beta = -0.50,
## 95% CI [-1.61, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.91, 95% CI [-6.65, 18.47], t(2038) = 0.92, p = 0.356; Std. beta = 0.35, 95%
## CI [-0.41, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.79, 95% CI [-11.80, 15.39], t(2038) = 0.26, p = 0.796; Std. beta = -0.43,
## 95% CI [-1.26, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.22, 20.12], t(2038) = 0.10, p = 0.923; Std. beta = -0.90,
## 95% CI [-2.88, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.15, 95% CI [-36.92, 28.62], t(2038) = -0.25, p = 0.804; Std. beta = -0.29,
## 95% CI [-2.19, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.04, 95% CI [-10.57, 18.65], t(2038) = 0.54, p = 0.588; Std. beta = 0.30,
## 95% CI [-0.56, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-4.71, 28.40], t(2038) = 1.40, p = 0.161; Std. beta = 0.36,
## 95% CI [-0.66, 1.38])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.89, 95% CI [-32.36, 0.57], t(2038) = -1.89, p = 0.059; Std. beta = -0.67,
## 95% CI [-1.75, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.32, 14.84], t(2038) = 0.35, p = 0.725; Std. beta = 0.09,
## 95% CI [-0.68, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-13.41, 24.94], t(2038) = 0.59, p = 0.555; Std. beta = 1.33,
## 95% CI [0.14, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-26.95, 2.56], t(2038) = -1.62, p = 0.105; Std. beta = -0.43,
## 95% CI [-1.36, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.88, 95% CI [-3.43, 29.19], t(2038) = 1.55, p = 0.121; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.53, 95% CI [1.47, 23.59], t(2038) = 2.22, p = 0.026; Std. beta = 0.48, 95%
## CI [-0.18, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.21, 95% CI [-14.55, 50.96], t(2038) = 1.09, p = 0.276; Std. beta = -2.80,
## 95% CI [-4.92, -0.69])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.92, 95% CI [5.84, 52.00], t(2038) = 2.46, p = 0.014; Std. beta = 1.70, 95%
## CI [0.24, 3.16])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-19.85, 18.12], t(2038) = -0.09, p = 0.929; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.44, 95% CI [-10.69, 9.81], t(2038) = -0.08, p = 0.932; Std. beta = 0.08,
## 95% CI [-0.84, 1.00])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.02, 95% CI [-0.52, 0.57], t(2038) = 0.08, p = 0.933;
## Std. beta = 2.42e-03, 95% CI [-0.05, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.04, 95% CI [-43.98, 13.89], t(2038) = -1.02, p = 0.308;
## Std. beta = -1.40, 95% CI [-4.10, 1.29])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.18, 11.51], t(2038) = 0.33, p = 0.740; Std.
## beta = 0.16, 95% CI [-0.76, 1.07])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.01, 95% CI [-15.84, 5.81], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.47, 95% CI [-1.48, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.13, p = 0.900;
## Std. beta = -0.07, 95% CI [-1.21, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-12.46, 6.40], t(2038) = -0.63, p = 0.528; Std.
## beta = -0.28, 95% CI [-1.16, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.84, 95% CI [-6.57, -1.10], t(2038) = -2.75, p = 0.006; Std.
## beta = -0.36, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.33, 95% CI [-14.61, 1.95], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.59, 95% CI [-1.36, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-2.78, 1.45], t(2038) = -0.62, p = 0.535; Std.
## beta = -0.06, 95% CI [-0.26, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-6.59, 1.56], t(2038) = -1.21, p = 0.227; Std.
## beta = -0.23, 95% CI [-0.61, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.99, 95% CI [0.13, 3.85], t(2038) = 2.09, p = 0.036; Std.
## beta = 0.19, 95% CI [0.01, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.49, 95% CI [-0.27, 13.25], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.61, 95% CI [-0.03, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-2.38, 1.78], t(2038) = -0.28, p = 0.777; Std.
## beta = -0.03, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-0.96, 5.21], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.20, 95% CI [-0.09, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.69, 95% CI [-5.45, 20.83], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.72, 95% CI [-0.51, 1.94])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.64, 95% CI [0.65, 12.64], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.62, 95% CI [0.06, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-2.17, 8.68], t(2038) = 1.18, p = 0.240; Std.
## beta = 0.30, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.26, 7.74], t(2038) = -0.06, p = 0.949; Std.
## beta = -0.02, 95% CI [-0.77, 0.72])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-9.69, 6.09], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.17, 95% CI [-0.90, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-33.95, 40.43], t(2038) = 0.17, p = 0.864; Std.
## beta = 0.30, 95% CI [-3.17, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.22, 19.42], t(2038) = -0.25, p = 0.799;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.72, 7.57], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.23, 95% CI [-0.25, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-14.50, 27.83], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.62, 95% CI [-1.35, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-6.96, 5.11], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.30, 7.10], t(2038) = 0.28, p = 0.776; Std.
## beta = 0.08, 95% CI [-0.49, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.35, 13.25], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.42, 95% CI [-0.41, 1.24])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.45, 95% CI [-8.68, 1.79], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.32, 95% CI [-0.81, 0.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-8.34, 11.29], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.14, 95% CI [-0.78, 1.05])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.49, 4.57], t(2038) = 0.02, p = 0.985; Std.
## beta = 4.04e-03, 95% CI [-0.42, 0.43])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.39, 95% CI [-11.70, -1.08], t(2038) = -2.36, p = 0.018;
## Std. beta = -0.60, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.32, 95% CI [-32.86, 10.22], t(2038) = -1.03, p = 0.303;
## Std. beta = -1.06, 95% CI [-3.06, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.51, 95% CI [-9.77, 8.75], t(2038) = -0.11, p = 0.914; Std.
## beta = -0.05, 95% CI [-0.91, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-3.02, 4.59], t(2038) = 0.40, p = 0.687; Std.
## beta = 0.07, 95% CI [-0.28, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.97, 95% CI [-10.37, 2.44], t(2038) = -1.22, p = 0.224; Std.
## beta = -0.37, 95% CI [-0.97, 0.23])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-4.40, 10.68], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.29, 95% CI [-0.41, 1.00])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-5.06, 4.09], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.05, 95% CI [-0.47, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.82, 95% CI [3.70, 19.93], t(2038) = 2.86, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.86])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.21, 8.87], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-7.66, 3.02], t(2038) = -0.85, p = 0.394; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.59, 0.58], t(2038) = -1.64, p = 0.101; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.03, 95% CI [-62.83, -29.24], t(2038) = -5.37, p < .001;
## Std. beta = -4.29, 95% CI [-5.86, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-8.70, 8.83], t(2038) = 0.01, p = 0.989; Std.
## beta = 5.69e-03, 95% CI [-0.81, 0.82])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-9.61, 12.07], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.11, 95% CI [-0.90, 1.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-9.28, 11.88], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.12, 95% CI [-0.87, 1.11])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT * site
## + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 60.52 (95% CI [54.70, 66.35], t(2038) = 20.37, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.30, 95% CI [-6.37, -2.22], t(2038) = -4.06, p < .001; Std. beta = -0.39, 95%
## CI [-0.48, -0.31])
## - The effect of OM 5yrPreDx is statistically non-significant and negative (beta
## = -0.32, 95% CI [-1.86, 1.21], t(2038) = -0.41, p = 0.678; Std. beta = -0.02,
## 95% CI [-0.12, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.82, 95% CI [-40.77, 25.14], t(2038) = -0.47, p = 0.642; Std. beta = -1.72,
## 95% CI [-4.41, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.92, 95% CI [-9.72, 37.56], t(2038) = 1.15, p = 0.248; Std. beta = 0.96,
## 95% CI [-0.44, 2.35])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-19.95, 26.16], t(2038) = 0.26, p = 0.792; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-30.25, 7.83], t(2038) = -1.15, p = 0.248; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.83, 44.22], t(2038) = 1.73, p = 0.085; Std. beta = 0.96,
## 95% CI [-0.52, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.56, 95% CI [3.20, 21.92], t(2038) = 2.63, p = 0.009; Std. beta = 0.41, 95%
## CI [-0.14, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.59, 95% CI [-1.60, 44.78], t(2038) = 1.83, p = 0.068; Std. beta = 0.73,
## 95% CI [-0.71, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.43, 9.49], t(2038) = 0.92, p = 0.358; Std. beta = 0.12, 95%
## CI [-0.27, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.05, 95% CI [-1.39, 23.48], t(2038) = 1.74, p = 0.082; Std. beta = 0.44,
## 95% CI [-0.31, 1.18])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-6.36, 4.44], t(2038) = -0.35, p = 0.727; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.59, 7.02], t(2038) = -0.89, p = 0.375; Std. beta = 0.21,
## 95% CI [-0.66, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.42, 10.98], t(2038) = 1.51, p = 0.131; Std. beta = 0.25, 95%
## CI [-0.12, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.80, 95% CI [-12.02, 4.41], t(2038) = -0.91, p = 0.364; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.86, 95% CI [-28.20, 18.47], t(2038) = -0.41, p = 0.683; Std. beta = 0.36,
## 95% CI [-1.18, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.83, 18.89], t(2038) = 3.01e-03, p = 0.998; Std. beta =
## 0.56, 95% CI [-0.56, 1.68])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.65, 95% CI [-19.59, 48.89], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.15, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.79, 95% CI [4.56, 37.02], t(2038) = 2.51, p = 0.012; Std. beta = 1.49, 95%
## CI [0.50, 2.48])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.32, 95% CI [-11.86, 34.51], t(2038) = 0.96, p = 0.338; Std. beta = 0.64,
## 95% CI [-0.80, 2.08])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.90, 95% CI [-1.48, 33.28], t(2038) = 1.79, p = 0.073; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.64, 95% CI [-22.83, 36.10], t(2038) = 0.44, p = 0.659; Std. beta = 0.66,
## 95% CI [-1.80, 3.12])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.28, 95% CI [-60.31, 5.74], t(2038) = -1.62, p = 0.105; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.04, 95% CI [-29.72, -0.35], t(2038) = -2.01, p = 0.045; Std. beta = -0.68,
## 95% CI [-1.59, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.81, 95% CI [-27.21, 38.82], t(2038) = 0.34, p = 0.730; Std. beta = 0.34,
## 95% CI [-1.60, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.90, 23.89], t(2038) = 0.04, p = 0.967; Std. beta = 0.59,
## 95% CI [-1.45, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.38, 95% CI [-4.56, 23.31], t(2038) = 1.32, p = 0.187; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-10.18, 17.17], t(2038) = 0.50, p = 0.616; Std. beta = 0.28,
## 95% CI [-0.59, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-27.82, 36.44], t(2038) = 0.26, p = 0.792; Std. beta = 0.63,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-9.35, 11.48], t(2038) = 0.20, p = 0.841; Std. beta = -0.23,
## 95% CI [-0.90, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.70, 95% CI [-25.65, 4.25], t(2038) = -1.40, p = 0.161; Std. beta = -0.50,
## 95% CI [-1.61, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.91, 95% CI [-6.65, 18.47], t(2038) = 0.92, p = 0.356; Std. beta = 0.35, 95%
## CI [-0.41, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.79, 95% CI [-11.80, 15.39], t(2038) = 0.26, p = 0.796; Std. beta = -0.43,
## 95% CI [-1.26, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.22, 20.12], t(2038) = 0.10, p = 0.923; Std. beta = -0.90,
## 95% CI [-2.88, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.15, 95% CI [-36.92, 28.62], t(2038) = -0.25, p = 0.804; Std. beta = -0.29,
## 95% CI [-2.19, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.04, 95% CI [-10.57, 18.65], t(2038) = 0.54, p = 0.588; Std. beta = 0.30,
## 95% CI [-0.56, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-4.71, 28.40], t(2038) = 1.40, p = 0.161; Std. beta = 0.36,
## 95% CI [-0.66, 1.38])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.89, 95% CI [-32.36, 0.57], t(2038) = -1.89, p = 0.059; Std. beta = -0.67,
## 95% CI [-1.75, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.32, 14.84], t(2038) = 0.35, p = 0.725; Std. beta = 0.09,
## 95% CI [-0.68, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-13.41, 24.94], t(2038) = 0.59, p = 0.555; Std. beta = 1.33,
## 95% CI [0.14, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-26.95, 2.56], t(2038) = -1.62, p = 0.105; Std. beta = -0.43,
## 95% CI [-1.36, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.88, 95% CI [-3.43, 29.19], t(2038) = 1.55, p = 0.121; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.53, 95% CI [1.47, 23.59], t(2038) = 2.22, p = 0.026; Std. beta = 0.48, 95%
## CI [-0.18, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.21, 95% CI [-14.55, 50.96], t(2038) = 1.09, p = 0.276; Std. beta = -2.80,
## 95% CI [-4.92, -0.69])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.92, 95% CI [5.84, 52.00], t(2038) = 2.46, p = 0.014; Std. beta = 1.70, 95%
## CI [0.24, 3.16])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-19.85, 18.12], t(2038) = -0.09, p = 0.929; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.44, 95% CI [-10.69, 9.81], t(2038) = -0.08, p = 0.932; Std. beta = 0.08,
## 95% CI [-0.84, 1.00])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.02, 95% CI [-0.52, 0.57], t(2038) = 0.08, p = 0.933;
## Std. beta = 2.42e-03, 95% CI [-0.05, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.04, 95% CI [-43.98, 13.89], t(2038) = -1.02, p = 0.308;
## Std. beta = -1.40, 95% CI [-4.10, 1.29])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.18, 11.51], t(2038) = 0.33, p = 0.740; Std.
## beta = 0.16, 95% CI [-0.76, 1.07])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.01, 95% CI [-15.84, 5.81], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.47, 95% CI [-1.48, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.13, p = 0.900;
## Std. beta = -0.07, 95% CI [-1.21, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-12.46, 6.40], t(2038) = -0.63, p = 0.528; Std.
## beta = -0.28, 95% CI [-1.16, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.84, 95% CI [-6.57, -1.10], t(2038) = -2.75, p = 0.006; Std.
## beta = -0.36, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.33, 95% CI [-14.61, 1.95], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.59, 95% CI [-1.36, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-2.78, 1.45], t(2038) = -0.62, p = 0.535; Std.
## beta = -0.06, 95% CI [-0.26, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-6.59, 1.56], t(2038) = -1.21, p = 0.227; Std.
## beta = -0.23, 95% CI [-0.61, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.99, 95% CI [0.13, 3.85], t(2038) = 2.09, p = 0.036; Std.
## beta = 0.19, 95% CI [0.01, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.49, 95% CI [-0.27, 13.25], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.61, 95% CI [-0.03, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-2.38, 1.78], t(2038) = -0.28, p = 0.777; Std.
## beta = -0.03, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-0.96, 5.21], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.20, 95% CI [-0.09, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.69, 95% CI [-5.45, 20.83], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.72, 95% CI [-0.51, 1.94])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.64, 95% CI [0.65, 12.64], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.62, 95% CI [0.06, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-2.17, 8.68], t(2038) = 1.18, p = 0.240; Std.
## beta = 0.30, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.26, 7.74], t(2038) = -0.06, p = 0.949; Std.
## beta = -0.02, 95% CI [-0.77, 0.72])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-9.69, 6.09], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.17, 95% CI [-0.90, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-33.95, 40.43], t(2038) = 0.17, p = 0.864; Std.
## beta = 0.30, 95% CI [-3.17, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.22, 19.42], t(2038) = -0.25, p = 0.799;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.72, 7.57], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.23, 95% CI [-0.25, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-14.50, 27.83], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.62, 95% CI [-1.35, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-6.96, 5.11], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.30, 7.10], t(2038) = 0.28, p = 0.776; Std.
## beta = 0.08, 95% CI [-0.49, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.35, 13.25], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.42, 95% CI [-0.41, 1.24])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.45, 95% CI [-8.68, 1.79], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.32, 95% CI [-0.81, 0.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-8.34, 11.29], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.14, 95% CI [-0.78, 1.05])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.49, 4.57], t(2038) = 0.02, p = 0.985; Std.
## beta = 4.04e-03, 95% CI [-0.42, 0.43])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.39, 95% CI [-11.70, -1.08], t(2038) = -2.36, p = 0.018;
## Std. beta = -0.60, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.32, 95% CI [-32.86, 10.22], t(2038) = -1.03, p = 0.303;
## Std. beta = -1.06, 95% CI [-3.06, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.51, 95% CI [-9.77, 8.75], t(2038) = -0.11, p = 0.914; Std.
## beta = -0.05, 95% CI [-0.91, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-3.02, 4.59], t(2038) = 0.40, p = 0.687; Std.
## beta = 0.07, 95% CI [-0.28, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.97, 95% CI [-10.37, 2.44], t(2038) = -1.22, p = 0.224; Std.
## beta = -0.37, 95% CI [-0.97, 0.23])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-4.40, 10.68], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.29, 95% CI [-0.41, 1.00])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-5.06, 4.09], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.05, 95% CI [-0.47, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.82, 95% CI [3.70, 19.93], t(2038) = 2.86, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.86])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.21, 8.87], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-7.66, 3.02], t(2038) = -0.85, p = 0.394; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.59, 0.58], t(2038) = -1.64, p = 0.101; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.03, 95% CI [-62.83, -29.24], t(2038) = -5.37, p < .001;
## Std. beta = -4.29, 95% CI [-5.86, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-8.70, 8.83], t(2038) = 0.01, p = 0.989; Std.
## beta = 5.69e-03, 95% CI [-0.81, 0.82])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-9.61, 12.07], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.11, 95% CI [-0.90, 1.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-9.28, 11.88], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.12, 95% CI [-0.87, 1.11])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to cohort
## = CARE-PF, is at 60.52 (95% CI [54.70, 66.35], t(2038) = 20.37, p < .001).
## Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.30, 95% CI [-6.37, -2.22], t(2038) = -4.06, p < .001; Std. beta = -0.39, 95%
## CI [-0.48, -0.31])
## - The effect of OM 5yrPreDx is statistically non-significant and negative (beta
## = -0.32, 95% CI [-1.86, 1.21], t(2038) = -0.41, p = 0.678; Std. beta = -0.02,
## 95% CI [-0.12, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.82, 95% CI [-40.77, 25.14], t(2038) = -0.47, p = 0.642; Std. beta = -1.72,
## 95% CI [-4.41, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.92, 95% CI [-9.72, 37.56], t(2038) = 1.15, p = 0.248; Std. beta = 0.96,
## 95% CI [-0.44, 2.35])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-19.95, 26.16], t(2038) = 0.26, p = 0.792; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-30.25, 7.83], t(2038) = -1.15, p = 0.248; Std. beta = -0.72,
## 95% CI [-2.06, 0.62])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.69, 95% CI [-2.83, 44.22], t(2038) = 1.73, p = 0.085; Std. beta = 0.96,
## 95% CI [-0.52, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.56, 95% CI [3.20, 21.92], t(2038) = 2.63, p = 0.009; Std. beta = 0.41, 95%
## CI [-0.14, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.59, 95% CI [-1.60, 44.78], t(2038) = 1.83, p = 0.068; Std. beta = 0.73,
## 95% CI [-0.71, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.43, 9.49], t(2038) = 0.92, p = 0.358; Std. beta = 0.12, 95%
## CI [-0.27, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.05, 95% CI [-1.39, 23.48], t(2038) = 1.74, p = 0.082; Std. beta = 0.44,
## 95% CI [-0.31, 1.18])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-6.36, 4.44], t(2038) = -0.35, p = 0.727; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.59, 7.02], t(2038) = -0.89, p = 0.375; Std. beta = 0.21,
## 95% CI [-0.66, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.42, 10.98], t(2038) = 1.51, p = 0.131; Std. beta = 0.25, 95%
## CI [-0.12, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.80, 95% CI [-12.02, 4.41], t(2038) = -0.91, p = 0.364; Std. beta = -0.04,
## 95% CI [-0.54, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.86, 95% CI [-28.20, 18.47], t(2038) = -0.41, p = 0.683; Std. beta = 0.36,
## 95% CI [-1.18, 1.90])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.83, 18.89], t(2038) = 3.01e-03, p = 0.998; Std. beta =
## 0.56, 95% CI [-0.56, 1.68])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.65, 95% CI [-19.59, 48.89], t(2038) = 0.84, p = 0.401; Std. beta = 0.86,
## 95% CI [-1.15, 2.87])
## - The effect of site [11R] is statistically significant and positive (beta =
## 20.79, 95% CI [4.56, 37.02], t(2038) = 2.51, p = 0.012; Std. beta = 1.49, 95%
## CI [0.50, 2.48])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.32, 95% CI [-11.86, 34.51], t(2038) = 0.96, p = 0.338; Std. beta = 0.64,
## 95% CI [-0.80, 2.08])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.90, 95% CI [-1.48, 33.28], t(2038) = 1.79, p = 0.073; Std. beta = 0.78,
## 95% CI [-0.27, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.64, 95% CI [-22.83, 36.10], t(2038) = 0.44, p = 0.659; Std. beta = 0.66,
## 95% CI [-1.80, 3.12])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.28, 95% CI [-60.31, 5.74], t(2038) = -1.62, p = 0.105; Std. beta = -1.84,
## 95% CI [-4.16, 0.47])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.04, 95% CI [-29.72, -0.35], t(2038) = -2.01, p = 0.045; Std. beta = -0.68,
## 95% CI [-1.59, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.81, 95% CI [-27.21, 38.82], t(2038) = 0.34, p = 0.730; Std. beta = 0.34,
## 95% CI [-1.60, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.90, 23.89], t(2038) = 0.04, p = 0.967; Std. beta = 0.59,
## 95% CI [-1.45, 2.63])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.38, 95% CI [-4.56, 23.31], t(2038) = 1.32, p = 0.187; Std. beta = 0.47, 95%
## CI [-0.41, 1.35])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-10.18, 17.17], t(2038) = 0.50, p = 0.616; Std. beta = 0.28,
## 95% CI [-0.59, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-27.82, 36.44], t(2038) = 0.26, p = 0.792; Std. beta = 0.63,
## 95% CI [-1.27, 2.52])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.06, 95% CI [-9.35, 11.48], t(2038) = 0.20, p = 0.841; Std. beta = -0.23,
## 95% CI [-0.90, 0.45])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.70, 95% CI [-25.65, 4.25], t(2038) = -1.40, p = 0.161; Std. beta = -0.50,
## 95% CI [-1.61, 0.60])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.91, 95% CI [-6.65, 18.47], t(2038) = 0.92, p = 0.356; Std. beta = 0.35, 95%
## CI [-0.41, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.79, 95% CI [-11.80, 15.39], t(2038) = 0.26, p = 0.796; Std. beta = -0.43,
## 95% CI [-1.26, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-18.22, 20.12], t(2038) = 0.10, p = 0.923; Std. beta = -0.90,
## 95% CI [-2.88, 1.08])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.15, 95% CI [-36.92, 28.62], t(2038) = -0.25, p = 0.804; Std. beta = -0.29,
## 95% CI [-2.19, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.04, 95% CI [-10.57, 18.65], t(2038) = 0.54, p = 0.588; Std. beta = 0.30,
## 95% CI [-0.56, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-4.71, 28.40], t(2038) = 1.40, p = 0.161; Std. beta = 0.36,
## 95% CI [-0.66, 1.38])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.89, 95% CI [-32.36, 0.57], t(2038) = -1.89, p = 0.059; Std. beta = -0.67,
## 95% CI [-1.75, 0.41])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.32, 14.84], t(2038) = 0.35, p = 0.725; Std. beta = 0.09,
## 95% CI [-0.68, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-13.41, 24.94], t(2038) = 0.59, p = 0.555; Std. beta = 1.33,
## 95% CI [0.14, 2.52])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-26.95, 2.56], t(2038) = -1.62, p = 0.105; Std. beta = -0.43,
## 95% CI [-1.36, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.88, 95% CI [-3.43, 29.19], t(2038) = 1.55, p = 0.121; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.53, 95% CI [1.47, 23.59], t(2038) = 2.22, p = 0.026; Std. beta = 0.48, 95%
## CI [-0.18, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.21, 95% CI [-14.55, 50.96], t(2038) = 1.09, p = 0.276; Std. beta = -2.80,
## 95% CI [-4.92, -0.69])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.92, 95% CI [5.84, 52.00], t(2038) = 2.46, p = 0.014; Std. beta = 1.70, 95%
## CI [0.24, 3.16])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-19.85, 18.12], t(2038) = -0.09, p = 0.929; Std. beta = 0.05,
## 95% CI [-1.23, 1.33])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.44, 95% CI [-10.69, 9.81], t(2038) = -0.08, p = 0.932; Std. beta = 0.08,
## 95% CI [-0.84, 1.00])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.02, 95% CI [-0.52, 0.57], t(2038) = 0.08, p = 0.933;
## Std. beta = 2.42e-03, 95% CI [-0.05, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.04, 95% CI [-43.98, 13.89], t(2038) = -1.02, p = 0.308;
## Std. beta = -1.40, 95% CI [-4.10, 1.29])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.18, 11.51], t(2038) = 0.33, p = 0.740; Std.
## beta = 0.16, 95% CI [-0.76, 1.07])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.01, 95% CI [-15.84, 5.81], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.47, 95% CI [-1.48, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-12.98, 11.42], t(2038) = -0.13, p = 0.900;
## Std. beta = -0.07, 95% CI [-1.21, 1.06])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-12.46, 6.40], t(2038) = -0.63, p = 0.528; Std.
## beta = -0.28, 95% CI [-1.16, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.84, 95% CI [-6.57, -1.10], t(2038) = -2.75, p = 0.006; Std.
## beta = -0.36, 95% CI [-0.61, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.33, 95% CI [-14.61, 1.95], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.59, 95% CI [-1.36, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-2.78, 1.45], t(2038) = -0.62, p = 0.535; Std.
## beta = -0.06, 95% CI [-0.26, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-6.59, 1.56], t(2038) = -1.21, p = 0.227; Std.
## beta = -0.23, 95% CI [-0.61, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.99, 95% CI [0.13, 3.85], t(2038) = 2.09, p = 0.036; Std.
## beta = 0.19, 95% CI [0.01, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.49, 95% CI [-0.27, 13.25], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.61, 95% CI [-0.03, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-2.38, 1.78], t(2038) = -0.28, p = 0.777; Std.
## beta = -0.03, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-0.96, 5.21], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.20, 95% CI [-0.09, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.69, 95% CI [-5.45, 20.83], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.72, 95% CI [-0.51, 1.94])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.64, 95% CI [0.65, 12.64], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.62, 95% CI [0.06, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-2.17, 8.68], t(2038) = 1.18, p = 0.240; Std.
## beta = 0.30, 95% CI [-0.20, 0.81])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.26, 7.74], t(2038) = -0.06, p = 0.949; Std.
## beta = -0.02, 95% CI [-0.77, 0.72])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-9.69, 6.09], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.17, 95% CI [-0.90, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-33.95, 40.43], t(2038) = 0.17, p = 0.864; Std.
## beta = 0.30, 95% CI [-3.17, 3.77])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.22, 19.42], t(2038) = -0.25, p = 0.799;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.72, 7.57], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.23, 95% CI [-0.25, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.66, 95% CI [-14.50, 27.83], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.62, 95% CI [-1.35, 2.59])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-6.96, 5.11], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.30, 7.10], t(2038) = 0.28, p = 0.776; Std.
## beta = 0.08, 95% CI [-0.49, 0.66])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.45, 95% CI [-4.35, 13.25], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.42, 95% CI [-0.41, 1.24])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.45, 95% CI [-8.68, 1.79], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.32, 95% CI [-0.81, 0.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-8.34, 11.29], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.14, 95% CI [-0.78, 1.05])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.49, 4.57], t(2038) = 0.02, p = 0.985; Std.
## beta = 4.04e-03, 95% CI [-0.42, 0.43])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.39, 95% CI [-11.70, -1.08], t(2038) = -2.36, p = 0.018;
## Std. beta = -0.60, 95% CI [-1.09, -0.10])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.32, 95% CI [-32.86, 10.22], t(2038) = -1.03, p = 0.303;
## Std. beta = -1.06, 95% CI [-3.06, 0.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.51, 95% CI [-9.77, 8.75], t(2038) = -0.11, p = 0.914; Std.
## beta = -0.05, 95% CI [-0.91, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-3.02, 4.59], t(2038) = 0.40, p = 0.687; Std.
## beta = 0.07, 95% CI [-0.28, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.97, 95% CI [-10.37, 2.44], t(2038) = -1.22, p = 0.224; Std.
## beta = -0.37, 95% CI [-0.97, 0.23])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-4.40, 10.68], t(2038) = 0.82, p = 0.414; Std.
## beta = 0.29, 95% CI [-0.41, 1.00])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-5.06, 4.09], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.05, 95% CI [-0.47, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.82, 95% CI [3.70, 19.93], t(2038) = 2.86, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.86])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.21, 8.87], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-7.66, 3.02], t(2038) = -0.85, p = 0.394; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-6.59, 0.58], t(2038) = -1.64, p = 0.101; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.03, 95% CI [-62.83, -29.24], t(2038) = -5.37, p < .001;
## Std. beta = -4.29, 95% CI [-5.86, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-8.70, 8.83], t(2038) = 0.01, p = 0.989; Std.
## beta = 5.69e-03, 95% CI [-0.81, 0.82])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-9.61, 12.07], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.11, 95% CI [-0.90, 1.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-9.28, 11.88], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.12, 95% CI [-0.87, 1.11])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*OM_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT * disadv +
## time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14188.5
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2776 -0.4394 -0.0117 0.4497 4.5164
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 231.88 15.228
## time_firstPFT 13.70 3.701 -0.07
## Residual 25.75 5.075
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 31.115857 6.467349 4.811
## time_firstPFT -1.656305 2.407013 -0.688
## OM_5yrPreDx 0.221467 0.776283 0.285
## disadv 3.975591 2.889503 1.376
## dich_RaceNon-White -7.406641 2.809520 -2.636
## sexF 3.554179 1.753723 2.027
## age_dx 0.387899 0.091230 4.252
## smokeHxFormer 3.745445 1.728914 2.166
## smokeHxAlways 18.767186 8.441124 2.223
## smokeHxUnknown -2.327399 3.922623 -0.593
## site02R -11.235524 16.154996 -0.695
## site03R 11.933889 11.688403 1.021
## site04R 3.203906 11.256305 0.285
## site05R -12.360100 9.340470 -1.323
## site06R 10.197672 16.167721 0.631
## site07R 11.752144 4.608633 2.550
## site09R 20.491358 11.363999 1.803
## site101 4.490882 3.214936 1.397
## site102 12.457854 6.148792 2.026
## site103 -1.158914 2.794171 -0.415
## site104 -6.681638 6.320288 -1.057
## site105 4.459267 3.087973 1.444
## site106 -5.446105 4.108671 -1.326
## site107 -2.157558 11.440326 -0.189
## site108 5.384241 9.664800 0.557
## site10R 12.543476 17.062035 0.735
## site11R 17.129251 7.950035 2.155
## site12R 7.517228 11.335265 0.663
## site13R 17.551115 8.570215 2.048
## site14R 6.140999 14.657860 0.419
## site15R -34.078791 16.191998 -2.105
## site16R -8.862871 7.285676 -1.216
## site17R 10.403345 16.294806 0.638
## site18R -3.265025 11.486431 -0.284
## site19R 9.365281 6.874877 1.362
## site20R 2.529891 6.702621 0.377
## site21R 2.522584 15.652599 0.161
## site22R -2.397231 5.184312 -0.462
## site23R -12.996336 8.824413 -1.473
## site24R 4.977245 6.146359 0.810
## site25R 0.661016 6.736514 0.098
## site28R 4.149781 9.430512 0.440
## site29R -6.014289 16.041144 -0.375
## site31R 5.602714 7.207658 0.777
## site32R 9.696990 8.151139 1.190
## site33R -13.936693 8.086825 -1.723
## site34R 0.243977 6.158918 0.040
## site35R -0.233445 9.413507 -0.025
## site36R -11.497933 7.240439 -1.588
## site37R 15.763901 8.074991 1.952
## site38R 12.481409 5.419914 2.303
## site39R 24.409552 16.313849 1.496
## site40R 25.539325 11.294486 2.261
## site41R -2.966423 9.354566 -0.317
## site42R -0.865883 5.085642 -0.170
## time_firstPFT:OM_5yrPreDx 0.043430 0.298607 0.145
## time_firstPFT:disadv -0.286489 1.130837 -0.253
## time_firstPFT:dich_RaceNon-White 0.126661 1.122337 0.113
## time_firstPFT:sexF -0.069484 0.673524 -0.103
## time_firstPFT:age_dx -0.052859 0.034978 -1.511
## time_firstPFT:smokeHxFormer 0.409600 0.678639 0.604
## time_firstPFT:smokeHxAlways 1.347478 5.332630 0.253
## time_firstPFT:smokeHxUnknown 1.517297 1.691588 0.897
## time_firstPFT:site02R -14.441658 14.805062 -0.975
## time_firstPFT:site03R 2.750735 5.110121 0.538
## time_firstPFT:site04R -4.602013 5.617110 -0.819
## time_firstPFT:site05R -0.458037 6.269794 -0.073
## time_firstPFT:site07R -3.384339 1.458438 -2.321
## time_firstPFT:site09R -6.207044 4.338292 -1.431
## time_firstPFT:site101 -0.468781 1.121694 -0.418
## time_firstPFT:site102 -2.630448 2.150492 -1.223
## time_firstPFT:site103 2.215156 1.024351 2.162
## time_firstPFT:site104 7.037018 3.552608 1.981
## time_firstPFT:site105 -0.237006 1.101351 -0.215
## time_firstPFT:site106 2.683027 1.643753 1.632
## time_firstPFT:site107 7.724102 6.747645 1.145
## time_firstPFT:site108 6.741979 3.321645 2.030
## time_firstPFT:site11R 4.049355 2.874318 1.409
## time_firstPFT:site12R 0.160724 4.190365 0.038
## time_firstPFT:site13R -1.347173 4.112439 -0.328
## time_firstPFT:site14R 3.633316 19.003485 0.191
## time_firstPFT:site15R -2.509312 11.436508 -0.219
## time_firstPFT:site16R 2.200673 2.731746 0.806
## time_firstPFT:site18R 7.234727 10.840597 0.667
## time_firstPFT:site19R -0.080857 3.171068 -0.025
## time_firstPFT:site20R 1.592195 3.243813 0.491
## time_firstPFT:site21R 4.642539 4.582242 1.013
## time_firstPFT:site22R -2.612083 2.744459 -0.952
## time_firstPFT:site23R 9.277867 24.741883 0.375
## time_firstPFT:site24R 0.152018 2.353984 0.065
## time_firstPFT:site25R -5.726909 2.799924 -2.045
## time_firstPFT:site28R -9.615215 11.112390 -0.865
## time_firstPFT:site29R 0.006993 4.834394 0.001
## time_firstPFT:site31R 0.882394 2.025065 0.436
## time_firstPFT:site32R -3.282686 3.353957 -0.979
## time_firstPFT:site33R 3.734858 3.983575 0.938
## time_firstPFT:site34R -0.199932 2.410433 -0.083
## time_firstPFT:site35R 12.751148 4.239949 3.007
## time_firstPFT:site36R 3.616030 2.899252 1.247
## time_firstPFT:site37R -1.703547 2.862029 -0.595
## time_firstPFT:site38R -2.739224 1.876713 -1.460
## time_firstPFT:site39R -46.302092 8.713892 -5.314
## time_firstPFT:site40R 1.211550 4.630052 0.262
## time_firstPFT:site41R 1.996136 5.584736 0.357
## time_firstPFT:site42R 2.191165 5.416418 0.405##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.917
## Unadjusted ICC: 0.690report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## OM_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 31.12 (95% CI [18.43, 43.80], t(2008)
## = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## OM_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to OM_5yrPreDx = 0, is at 31.12 (95% CI
## [18.43, 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 31.12 (95% CI [18.43,
## 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to dich_Race = White, is at 31.12 (95% CI
## [18.43, 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 31.12 (95% CI [18.43,
## 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 31.12 (95% CI [18.43,
## 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 31.12 (95% CI
## [18.43, 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 31.12 (95% CI [18.43,
## 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to cohort = CARE-PF, is at 31.12 (95% CI
## [18.43, 43.80], t(2008) = 4.81, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.66, 95% CI [-6.38, 3.06], t(2008) = -0.69, p = 0.491; Std. beta =
## -0.45, 95% CI [-0.59, -0.30])
## - The effect of OM 5yrPreDx is statistically non-significant and positive (beta
## = 0.22, 95% CI [-1.30, 1.74], t(2008) = 0.29, p = 0.775; Std. beta = 0.02, 95%
## CI [-0.09, 0.12])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.98, 95% CI [-1.69, 9.64], t(2008) = 1.38, p = 0.169; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.41, 95% CI [-12.92, -1.90], t(2008) = -2.64, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.77, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.55,
## 95% CI [0.11, 6.99], t(2008) = 2.03, p = 0.043; Std. beta = 0.20, 95% CI
## [-0.01, 0.42])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.25, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.75, 95% CI [0.35, 7.14], t(2008) = 2.17, p = 0.030; Std. beta = 0.25,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.77, 95% CI [2.21, 35.32], t(2008) = 2.22, p = 0.026; Std. beta =
## 1.21, 95% CI [0.04, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.33, 95% CI [-10.02, 5.37], t(2008) = -0.59, p = 0.553; Std. beta =
## -8.36e-03, 95% CI [-0.51, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-42.92, 20.45], t(2008) = -0.70, p = 0.487; Std. beta =
## -1.88, 95% CI [-4.54, 0.79])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.93, 95% CI [-10.99, 34.86], t(2008) = 1.02, p = 0.307; Std. beta = 0.93,
## 95% CI [-0.44, 2.31])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-18.87, 25.28], t(2008) = 0.28, p = 0.776; Std. beta = -0.20,
## 95% CI [-1.66, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-30.68, 5.96], t(2008) = -1.32, p = 0.186; Std. beta = -0.76,
## 95% CI [-2.08, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.20, 95% CI [-21.51, 41.90], t(2008) = 0.63, p = 0.528; Std. beta = 0.60,
## 95% CI [-1.26, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.75, 95% CI [2.71, 20.79], t(2008) = 2.55, p = 0.011; Std. beta = 0.40, 95%
## CI [-0.14, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.49, 95% CI [-1.80, 42.78], t(2008) = 1.80, p = 0.072; Std. beta = 0.68,
## 95% CI [-0.73, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.81, 10.80], t(2008) = 1.40, p = 0.163; Std. beta = 0.22, 95%
## CI [-0.17, 0.61])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.46, 95% CI [0.40, 24.52], t(2008) = 2.03, p = 0.043; Std. beta = 0.51, 95%
## CI [-0.23, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-6.64, 4.32], t(2008) = -0.41, p = 0.678; Std. beta = 0.12,
## 95% CI [-0.22, 0.46])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.68, 95% CI [-19.08, 5.71], t(2008) = -1.06, p = 0.291; Std. beta = 0.20,
## 95% CI [-0.66, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.60, 10.52], t(2008) = 1.44, p = 0.149; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.50, 2.61], t(2008) = -1.33, p = 0.185; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-24.59, 20.28], t(2008) = -0.19, p = 0.850; Std. beta = 0.53,
## 95% CI [-0.99, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.57, 24.34], t(2008) = 0.56, p = 0.578; Std. beta = 0.88,
## 95% CI [-0.26, 2.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.54, 95% CI [-20.92, 46.00], t(2008) = 0.74, p = 0.462; Std. beta = 0.74,
## 95% CI [-1.23, 2.70])
## - The effect of site [11R] is statistically significant and positive (beta =
## 17.13, 95% CI [1.54, 32.72], t(2008) = 2.15, p = 0.031; Std. beta = 1.35, 95%
## CI [0.38, 2.31])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.52, 95% CI [-14.71, 29.75], t(2008) = 0.66, p = 0.507; Std. beta = 0.45,
## 95% CI [-0.96, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.55, 95% CI [0.74, 34.36], t(2008) = 2.05, p = 0.041; Std. beta = 0.92, 95%
## CI [-0.12, 1.95])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.14, 95% CI [-22.61, 34.89], t(2008) = 0.42, p = 0.675; Std. beta = 0.67,
## 95% CI [-1.79, 3.12])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.08, 95% CI [-65.83, -2.32], t(2008) = -2.10, p = 0.035; Std. beta = -2.21,
## 95% CI [-4.49, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.86, 95% CI [-23.15, 5.43], t(2008) = -1.22, p = 0.224; Std. beta = -0.33,
## 95% CI [-1.24, 0.57])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.40, 95% CI [-21.55, 42.36], t(2008) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-25.79, 19.26], t(2008) = -0.28, p = 0.776; Std. beta = 0.42,
## 95% CI [-1.60, 2.44])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.37, 95% CI [-4.12, 22.85], t(2008) = 1.36, p = 0.173; Std. beta = 0.54, 95%
## CI [-0.33, 1.41])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.61, 15.67], t(2008) = 0.38, p = 0.706; Std. beta = 0.28,
## 95% CI [-0.57, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.52, 95% CI [-28.17, 33.22], t(2008) = 0.16, p = 0.872; Std. beta = 0.54,
## 95% CI [-1.30, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-12.56, 7.77], t(2008) = -0.46, p = 0.644; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-30.30, 4.31], t(2008) = -1.47, p = 0.141; Std. beta = 0.02,
## 95% CI [-3.80, 3.84])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.98, 95% CI [-7.08, 17.03], t(2008) = 0.81, p = 0.418; Std. beta = 0.30, 95%
## CI [-0.44, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-12.55, 13.87], t(2008) = 0.10, p = 0.922; Std. beta = -0.44,
## 95% CI [-1.27, 0.38])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.15, 95% CI [-14.34, 22.64], t(2008) = 0.44, p = 0.660; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-37.47, 25.44], t(2008) = -0.37, p = 0.708; Std. beta = -0.35,
## 95% CI [-2.21, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-8.53, 19.74], t(2008) = 0.78, p = 0.437; Std. beta = 0.40, 95%
## CI [-0.44, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.70, 95% CI [-6.29, 25.68], t(2008) = 1.19, p = 0.234; Std. beta = 0.29, 95%
## CI [-0.72, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.94, 95% CI [-29.80, 1.92], t(2008) = -1.72, p = 0.085; Std. beta = -0.50,
## 95% CI [-1.57, 0.57])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-11.83, 12.32], t(2008) = 0.04, p = 0.968; Std. beta =
## -2.56e-03, 95% CI [-0.75, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-18.69, 18.23], t(2008) = -0.02, p = 0.980; Std. beta = 1.06,
## 95% CI [-0.11, 2.23])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.70, 2.70], t(2008) = -1.59, p = 0.112; Std. beta = -0.37,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.76, 95% CI [-0.07, 31.60], t(2008) = 1.95, p = 0.051; Std. beta = 0.78,
## 95% CI [-0.19, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.85, 23.11], t(2008) = 2.30, p = 0.021; Std. beta = 0.50, 95%
## CI [-0.15, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.41, 95% CI [-7.58, 56.40], t(2008) = 1.50, p = 0.135; Std. beta = -2.48,
## 95% CI [-4.58, -0.37])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.54, 95% CI [3.39, 47.69], t(2008) = 2.26, p = 0.024; Std. beta = 1.60, 95%
## CI [0.16, 3.04])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.97, 95% CI [-21.31, 15.38], t(2008) = -0.32, p = 0.751; Std. beta =
## -5.43e-03, 95% CI [-1.27, 1.26])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.87, 95% CI [-10.84, 9.11], t(2008) = -0.17, p = 0.865; Std. beta = 0.13,
## 95% CI [-0.79, 1.05])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.04, 95% CI [-0.54, 0.63], t(2008) = 0.15, p = 0.884;
## Std. beta = 4.51e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.29, 95% CI [-2.50, 1.93], t(2008) = -0.25, p = 0.800; Std.
## beta = -7.67e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.07, 2.33], t(2008) =
## 0.11, p = 0.910; Std. beta = 0.01, 95% CI [-0.19, 0.22])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-1.39, 1.25], t(2008) = -0.10, p = 0.918; Std.
## beta = -6.49e-03, 95% CI [-0.13, 0.12])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.51, p = 0.131; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.41, 95% CI [-0.92, 1.74], t(2008) =
## 0.60, p = 0.546; Std. beta = 0.04, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.11, 11.81], t(2008) =
## 0.25, p = 0.801; Std. beta = 0.13, 95% CI [-0.85, 1.10])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.52, 95% CI [-1.80, 4.83], t(2008) =
## 0.90, p = 0.370; Std. beta = 0.14, 95% CI [-0.17, 0.45])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.44, 95% CI [-43.48, 14.59], t(2008) = -0.98, p = 0.329;
## Std. beta = -1.35, 95% CI [-4.06, 1.36])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.75, 95% CI [-7.27, 12.77], t(2008) = 0.54, p = 0.590; Std.
## beta = 0.26, 95% CI [-0.68, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.60, 95% CI [-15.62, 6.41], t(2008) = -0.82, p = 0.413; Std.
## beta = -0.43, 95% CI [-1.46, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-12.75, 11.84], t(2008) = -0.07, p = 0.942;
## Std. beta = -0.04, 95% CI [-1.19, 1.11])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.38, 95% CI [-6.24, -0.52], t(2008) = -2.32, p = 0.020; Std.
## beta = -0.32, 95% CI [-0.58, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.21, 95% CI [-14.72, 2.30], t(2008) = -1.43, p = 0.153; Std.
## beta = -0.58, 95% CI [-1.37, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-2.67, 1.73], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.04, 95% CI [-0.25, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-6.85, 1.59], t(2008) = -1.22, p = 0.221; Std.
## beta = -0.25, 95% CI [-0.64, 0.15])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.22, 95% CI [0.21, 4.22], t(2008) = 2.16, p = 0.031; Std.
## beta = 0.21, 95% CI [0.02, 0.39])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.04, 95% CI [0.07, 14.00], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.66, 95% CI [6.51e-03, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-2.40, 1.92], t(2008) = -0.22, p = 0.830; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.54, 5.91], t(2008) = 1.63, p = 0.103; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.51, 20.96], t(2008) = 1.14, p = 0.252; Std.
## beta = 0.72, 95% CI [-0.51, 1.96])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.74, 95% CI [0.23, 13.26], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.63, 95% CI [0.02, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.59, 9.69], t(2008) = 1.41, p = 0.159; Std.
## beta = 0.38, 95% CI [-0.15, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-8.06, 8.38], t(2008) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-9.41, 6.72], t(2008) = -0.33, p = 0.743; Std.
## beta = -0.13, 95% CI [-0.88, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-33.64, 40.90], t(2008) = 0.19, p = 0.848; Std.
## beta = 0.34, 95% CI [-3.14, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-24.94, 19.92], t(2008) = -0.22, p = 0.826;
## Std. beta = -0.23, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-3.16, 7.56], t(2008) = 0.81, p = 0.421; Std.
## beta = 0.21, 95% CI [-0.29, 0.71])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.23, 95% CI [-14.03, 28.49], t(2008) = 0.67, p = 0.505; Std.
## beta = 0.68, 95% CI [-1.31, 2.66])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-6.30, 6.14], t(2008) = -0.03, p = 0.980; Std.
## beta = -7.60e-03, 95% CI [-0.59, 0.57])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.77, 7.95], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.15, 95% CI [-0.45, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-4.34, 13.63], t(2008) = 1.01, p = 0.311; Std.
## beta = 0.43, 95% CI [-0.41, 1.27])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-7.99, 2.77], t(2008) = -0.95, p = 0.341; Std.
## beta = -0.24, 95% CI [-0.75, 0.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-39.24, 57.80], t(2008) = 0.37, p = 0.708; Std.
## beta = 0.87, 95% CI [-3.67, 5.40])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-4.46, 4.77], t(2008) = 0.06, p = 0.949; Std.
## beta = 0.01, 95% CI [-0.42, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.73, 95% CI [-11.22, -0.24], t(2008) = -2.05, p = 0.041;
## Std. beta = -0.54, 95% CI [-1.05, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-31.41, 12.18], t(2008) = -0.87, p = 0.387;
## Std. beta = -0.90, 95% CI [-2.93, 1.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 6.99e-03, 95% CI [-9.47, 9.49], t(2008) = 1.45e-03, p = 0.999;
## Std. beta = 6.27e-04, 95% CI [-0.89, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-3.09, 4.85], t(2008) = 0.44, p = 0.663; Std.
## beta = 0.08, 95% CI [-0.29, 0.45])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.28, 95% CI [-9.86, 3.29], t(2008) = -0.98, p = 0.328; Std.
## beta = -0.31, 95% CI [-0.92, 0.31])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-4.08, 11.55], t(2008) = 0.94, p = 0.349; Std.
## beta = 0.35, 95% CI [-0.38, 1.08])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-4.93, 4.53], t(2008) = -0.08, p = 0.934; Std.
## beta = -0.02, 95% CI [-0.46, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.75, 95% CI [4.44, 21.07], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.19, 95% CI [0.41, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.07, 9.30], t(2008) = 1.25, p = 0.212; Std.
## beta = 0.34, 95% CI [-0.19, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-7.32, 3.91], t(2008) = -0.60, p = 0.552; Std.
## beta = -0.16, 95% CI [-0.68, 0.37])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.42, 0.94], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.30, 95% CI [-63.39, -29.21], t(2008) = -5.31, p < .001;
## Std. beta = -4.33, 95% CI [-5.92, -2.73])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-7.87, 10.29], t(2008) = 0.26, p = 0.794; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-8.96, 12.95], t(2008) = 0.36, p = 0.721; Std.
## beta = 0.19, 95% CI [-0.84, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-8.43, 12.81], t(2008) = 0.40, p = 0.686; Std.
## beta = 0.20, 95% CI [-0.79, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*SS_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14366.5
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3179 -0.4377 -0.0170 0.4497 4.5492
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 253.66 15.927
## time_firstPFT 12.73 3.567 -0.10
## Residual 25.73 5.072
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 62.353497 1.971618 31.626
## time_firstPFT -4.925060 0.699257 -7.043
## SS_5yrPreDx -13.372462 6.743013 -1.983
## site02R 21.665783 22.350103 0.969
## site03R 12.860571 12.015770 1.070
## site04R 3.222594 11.692561 0.276
## site05R -12.774182 9.700582 -1.317
## site06R 19.539107 11.895246 1.643
## site07R 12.531422 4.710514 2.660
## site09R 24.148972 11.824762 2.042
## site101 3.032864 3.210116 0.945
## site102 9.389309 6.369706 1.474
## site103 0.398157 2.778002 0.143
## site104 -5.196504 6.415188 -0.810
## site105 4.564109 3.144470 1.451
## site106 -3.702485 4.160012 -0.890
## site107 -4.464758 11.851864 -0.377
## site108 -2.072457 9.609636 -0.216
## site10R 22.177693 18.624959 1.191
## site11R 21.538516 8.243438 2.613
## site12R 10.103275 11.760206 0.859
## site13R 15.847394 8.809559 1.799
## site14R 8.277832 14.961642 0.553
## site15R -27.614081 16.763765 -1.647
## site16R -12.034865 7.598009 -1.584
## site17R 4.847824 16.775120 0.289
## site18R 4.744715 12.055148 0.394
## site19R 9.274150 6.908003 1.343
## site20R 2.443291 6.940010 0.352
## site21R 4.285245 16.311306 0.263
## site22R 2.703457 5.276615 0.512
## site23R -7.934185 7.676668 -1.034
## site24R 5.202122 6.366459 0.817
## site25R 19.135155 11.125624 1.720
## site28R 0.171374 9.738080 0.018
## site29R 0.555534 16.731360 0.033
## site31R 4.067574 7.397938 0.550
## site32R 12.527598 8.352914 1.500
## site33R -10.530724 8.706977 -1.209
## site34R 2.217189 6.342379 0.350
## site35R 6.336940 9.697628 0.653
## site36R -13.035709 7.491307 -1.740
## site37R 12.901134 8.273787 1.559
## site38R 12.319188 5.614950 2.194
## site39R 16.518049 16.619005 0.994
## site40R 30.251120 11.734414 2.578
## site41R 1.052327 9.676867 0.109
## site42R 0.678356 5.197555 0.131
## time_firstPFT:SS_5yrPreDx 3.319489 2.449565 1.355
## time_firstPFT:site02R -22.366109 15.705839 -1.424
## time_firstPFT:site03R 1.874322 5.009560 0.374
## time_firstPFT:site04R -4.935059 5.495557 -0.898
## time_firstPFT:site05R -0.398723 6.218780 -0.064
## time_firstPFT:site06R -2.873250 4.763851 -0.603
## time_firstPFT:site07R -3.798724 1.365657 -2.782
## time_firstPFT:site09R -6.950233 4.217073 -1.648
## time_firstPFT:site101 -0.636166 1.046087 -0.608
## time_firstPFT:site102 -2.118348 2.085545 -1.016
## time_firstPFT:site103 1.658140 0.966486 1.716
## time_firstPFT:site104 6.348883 3.435861 1.848
## time_firstPFT:site105 -0.262176 1.044045 -0.251
## time_firstPFT:site106 2.163117 1.560346 1.386
## time_firstPFT:site107 7.589901 6.689599 1.135
## time_firstPFT:site108 7.215488 3.053996 2.363
## time_firstPFT:site11R 2.950035 2.750761 1.072
## time_firstPFT:site12R 0.007329 4.048999 0.002
## time_firstPFT:site13R -1.832681 3.988169 -0.460
## time_firstPFT:site14R 2.939861 18.960001 0.155
## time_firstPFT:site15R -2.873848 11.371302 -0.253
## time_firstPFT:site16R 1.849048 2.628747 0.703
## time_firstPFT:site18R 5.697685 10.799843 0.528
## time_firstPFT:site19R -0.809258 3.022287 -0.268
## time_firstPFT:site20R 1.205468 3.142118 0.384
## time_firstPFT:site21R 4.415629 4.456288 0.991
## time_firstPFT:site22R -4.016088 2.674032 -1.502
## time_firstPFT:site23R 0.515552 5.028373 0.103
## time_firstPFT:site24R 0.260080 2.295069 0.113
## time_firstPFT:site25R -10.453046 3.958155 -2.641
## time_firstPFT:site28R -11.112428 10.979258 -1.012
## time_firstPFT:site29R -1.609595 4.736299 -0.340
## time_firstPFT:site31R 0.820194 1.914569 0.428
## time_firstPFT:site32R -4.244846 3.254987 -1.304
## time_firstPFT:site33R 1.718260 3.944391 0.436
## time_firstPFT:site34R -0.388412 2.306211 -0.168
## time_firstPFT:site35R 11.831389 4.103508 2.883
## time_firstPFT:site36R 3.461546 2.804010 1.234
## time_firstPFT:site37R -2.341125 2.703358 -0.866
## time_firstPFT:site38R -2.971962 1.815044 -1.637
## time_firstPFT:site39R -45.535545 8.546320 -5.328
## time_firstPFT:site40R 0.248864 4.412367 0.056
## time_firstPFT:site41R 0.739415 5.527305 0.134
## time_firstPFT:site42R 1.157340 5.383536 0.215##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.920
## Unadjusted ICC: 0.738report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SS_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 62.35 (95% CI [58.49,
## 66.22], t(2038) = 31.63, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.93, 95% CI [-6.30, -3.55], t(2038) = -7.04, p < .001; Std. beta = -0.38, 95%
## CI [-0.47, -0.30])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -13.37, 95% CI [-26.60, -0.15], t(2038) = -1.98, p = 0.047; Std. beta = -0.10,
## 95% CI [-0.25, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.67, 95% CI [-22.17, 65.50], t(2038) = 0.97, p = 0.332; Std. beta = -0.61,
## 95% CI [-3.83, 2.61])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.86, 95% CI [-10.70, 36.43], t(2038) = 1.07, p = 0.285; Std. beta = 0.91,
## 95% CI [-0.48, 2.30])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-19.71, 26.15], t(2038) = 0.28, p = 0.783; Std. beta = -0.23,
## 95% CI [-1.71, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.77, 95% CI [-31.80, 6.25], t(2038) = -1.32, p = 0.188; Std. beta = -0.78,
## 95% CI [-2.12, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.54, 95% CI [-3.79, 42.87], t(2038) = 1.64, p = 0.101; Std. beta = 0.90,
## 95% CI [-0.57, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.53, 95% CI [3.29, 21.77], t(2038) = 2.66, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.13, 0.97])
## - The effect of site [09R] is statistically significant and positive (beta =
## 24.15, 95% CI [0.96, 47.34], t(2038) = 2.04, p = 0.041; Std. beta = 0.83, 95%
## CI [-0.61, 2.27])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.26, 9.33], t(2038) = 0.94, p = 0.345; Std. beta = 0.12, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.39, 95% CI [-3.10, 21.88], t(2038) = 1.47, p = 0.141; Std. beta = 0.37, 95%
## CI [-0.38, 1.12])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.05, 5.85], t(2038) = 0.14, p = 0.886; Std. beta = 0.16, 95%
## CI [-0.17, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-17.78, 7.38], t(2038) = -0.81, p = 0.418; Std. beta = 0.23,
## 95% CI [-0.63, 1.09])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-1.60, 10.73], t(2038) = 1.45, p = 0.147; Std. beta = 0.25, 95%
## CI [-0.13, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-11.86, 4.46], t(2038) = -0.89, p = 0.374; Std. beta = -0.04,
## 95% CI [-0.53, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-27.71, 18.78], t(2038) = -0.38, p = 0.706; Std. beta = 0.38,
## 95% CI [-1.16, 1.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.07, 95% CI [-20.92, 16.77], t(2038) = -0.22, p = 0.829; Std. beta = 0.49,
## 95% CI [-0.64, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 22.18, 95% CI [-14.35, 58.70], t(2038) = 1.19, p = 0.234; Std. beta = 1.30,
## 95% CI [-0.84, 3.44])
## - The effect of site [11R] is statistically significant and positive (beta =
## 21.54, 95% CI [5.37, 37.70], t(2038) = 2.61, p = 0.009; Std. beta = 1.51, 95%
## CI [0.53, 2.50])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-12.96, 33.17], t(2038) = 0.86, p = 0.390; Std. beta = 0.59,
## 95% CI [-0.84, 2.03])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-1.43, 33.12], t(2038) = 1.80, p = 0.072; Std. beta = 0.78,
## 95% CI [-0.27, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.28, 95% CI [-21.06, 37.62], t(2038) = 0.55, p = 0.580; Std. beta = 0.73,
## 95% CI [-1.73, 3.19])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.61, 95% CI [-60.49, 5.26], t(2038) = -1.65, p = 0.100; Std. beta = -1.86,
## 95% CI [-4.17, 0.45])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -12.03, 95% CI [-26.94, 2.87], t(2038) = -1.58, p = 0.113; Std. beta = -0.55,
## 95% CI [-1.47, 0.37])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-28.05, 37.75], t(2038) = 0.29, p = 0.773; Std. beta = 0.28,
## 95% CI [-1.64, 2.21])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 4.74, 95% CI [-18.90, 28.39], t(2038) = 0.39, p = 0.694; Std. beta = 0.76,
## 95% CI [-1.29, 2.80])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-4.27, 22.82], t(2038) = 1.34, p = 0.180; Std. beta = 0.48, 95%
## CI [-0.38, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-11.17, 16.05], t(2038) = 0.35, p = 0.725; Std. beta = 0.24,
## 95% CI [-0.62, 1.11])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-27.70, 36.27], t(2038) = 0.26, p = 0.793; Std. beta = 0.62,
## 95% CI [-1.27, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.70, 95% CI [-7.64, 13.05], t(2038) = 0.51, p = 0.608; Std. beta = -0.18,
## 95% CI [-0.85, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -7.93, 95% CI [-22.99, 7.12], t(2038) = -1.03, p = 0.301; Std. beta = -0.42,
## 95% CI [-1.53, 0.69])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.20, 95% CI [-7.28, 17.69], t(2038) = 0.82, p = 0.414; Std. beta = 0.33, 95%
## CI [-0.43, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 19.14, 95% CI [-2.68, 40.95], t(2038) = 1.72, p = 0.086; Std. beta = 0.24,
## 95% CI [-1.07, 1.56])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-18.93, 19.27], t(2038) = 0.02, p = 0.986; Std. beta = -0.92,
## 95% CI [-2.90, 1.05])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-32.26, 33.37], t(2038) = 0.03, p = 0.974; Std. beta = -0.10,
## 95% CI [-2.02, 1.81])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.07, 95% CI [-10.44, 18.58], t(2038) = 0.55, p = 0.582; Std. beta = 0.31,
## 95% CI [-0.55, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.53, 95% CI [-3.85, 28.91], t(2038) = 1.50, p = 0.134; Std. beta = 0.38,
## 95% CI [-0.64, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-27.61, 6.54], t(2038) = -1.21, p = 0.227; Std. beta = -0.47,
## 95% CI [-1.59, 0.64])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.22, 14.66], t(2038) = 0.35, p = 0.727; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-12.68, 25.36], t(2038) = 0.65, p = 0.514; Std. beta = 1.37,
## 95% CI [0.19, 2.55])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-27.73, 1.66], t(2038) = -1.74, p = 0.082; Std. beta = -0.47,
## 95% CI [-1.39, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-3.32, 29.13], t(2038) = 1.56, p = 0.119; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.32, 95% CI [1.31, 23.33], t(2038) = 2.19, p = 0.028; Std. beta = 0.47, 95%
## CI [-0.19, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.52, 95% CI [-16.07, 49.11], t(2038) = 0.99, p = 0.320; Std. beta = -2.86,
## 95% CI [-4.97, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.25, 95% CI [7.24, 53.26], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.34, 3.25])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 1.05, 95% CI [-17.93, 20.03], t(2038) = 0.11, p = 0.913; Std. beta = 0.12,
## 95% CI [-1.16, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.68, 95% CI [-9.51, 10.87], t(2038) = 0.13, p = 0.896; Std. beta = 0.14, 95%
## CI [-0.78, 1.05])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.32, 95% CI [-1.48, 8.12], t(2038) = 1.36, p = 0.176;
## Std. beta = 0.06, 95% CI [-0.03, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -22.37, 95% CI [-53.17, 8.44], t(2038) = -1.42, p = 0.155;
## Std. beta = -2.09, 95% CI [-4.96, 0.79])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-7.95, 11.70], t(2038) = 0.37, p = 0.708; Std.
## beta = 0.17, 95% CI [-0.74, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.94, 95% CI [-15.71, 5.84], t(2038) = -0.90, p = 0.369; Std.
## beta = -0.46, 95% CI [-1.46, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-12.59, 11.80], t(2038) = -0.06, p = 0.949;
## Std. beta = -0.04, 95% CI [-1.17, 1.10])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-12.22, 6.47], t(2038) = -0.60, p = 0.546; Std.
## beta = -0.27, 95% CI [-1.14, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.80, 95% CI [-6.48, -1.12], t(2038) = -2.78, p = 0.005; Std.
## beta = -0.35, 95% CI [-0.60, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.95, 95% CI [-15.22, 1.32], t(2038) = -1.65, p = 0.099; Std.
## beta = -0.65, 95% CI [-1.42, 0.12])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-2.69, 1.42], t(2038) = -0.61, p = 0.543; Std.
## beta = -0.06, 95% CI [-0.25, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-6.21, 1.97], t(2038) = -1.02, p = 0.310; Std.
## beta = -0.20, 95% CI [-0.58, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-0.24, 3.55], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.15, 95% CI [-0.02, 0.33])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.35, 95% CI [-0.39, 13.09], t(2038) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.31, 1.79], t(2038) = -0.25, p = 0.802; Std.
## beta = -0.02, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-0.90, 5.22], t(2038) = 1.39, p = 0.166; Std.
## beta = 0.20, 95% CI [-0.08, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.59, 95% CI [-5.53, 20.71], t(2038) = 1.13, p = 0.257; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.22, 95% CI [1.23, 13.20], t(2038) = 2.36, p = 0.018; Std.
## beta = 0.67, 95% CI [0.11, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-2.44, 8.34], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.28, 95% CI [-0.23, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 7.33e-03, 95% CI [-7.93, 7.95], t(2038) = 1.81e-03, p = 0.999;
## Std. beta = 6.81e-04, 95% CI [-0.74, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-9.65, 5.99], t(2038) = -0.46, p = 0.646; Std.
## beta = -0.17, 95% CI [-0.90, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-34.24, 40.12], t(2038) = 0.16, p = 0.877; Std.
## beta = 0.27, 95% CI [-3.19, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-25.17, 19.43], t(2038) = -0.25, p = 0.801;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-3.31, 7.00], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.70, 95% CI [-15.48, 26.88], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.53, 95% CI [-1.44, 2.51])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-6.74, 5.12], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.08, 95% CI [-0.63, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-4.96, 7.37], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.11, 95% CI [-0.46, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-4.32, 13.15], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.41, 95% CI [-0.40, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.02, 95% CI [-9.26, 1.23], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.37, 95% CI [-0.86, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-9.35, 10.38], t(2038) = 0.10, p = 0.918; Std.
## beta = 0.05, 95% CI [-0.87, 0.97])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-4.24, 4.76], t(2038) = 0.11, p = 0.910; Std.
## beta = 0.02, 95% CI [-0.40, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -10.45, 95% CI [-18.22, -2.69], t(2038) = -2.64, p = 0.008;
## Std. beta = -0.97, 95% CI [-1.70, -0.25])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.11, 95% CI [-32.64, 10.42], t(2038) = -1.01, p = 0.312;
## Std. beta = -1.04, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-10.90, 7.68], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.15, 95% CI [-1.02, 0.72])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-2.93, 4.57], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.08, 95% CI [-0.27, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-10.63, 2.14], t(2038) = -1.30, p = 0.192; Std.
## beta = -0.40, 95% CI [-0.99, 0.20])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-6.02, 9.45], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.16, 95% CI [-0.56, 0.88])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-4.91, 4.13], t(2038) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.46, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.83, 95% CI [3.78, 19.88], t(2038) = 2.88, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.46, 95% CI [-2.04, 8.96], t(2038) = 1.23, p = 0.217; Std.
## beta = 0.32, 95% CI [-0.19, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-7.64, 2.96], t(2038) = -0.87, p = 0.387; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-6.53, 0.59], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.54, 95% CI [-62.30, -28.78], t(2038) = -5.33, p < .001;
## Std. beta = -4.25, 95% CI [-5.81, -2.68])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-8.40, 8.90], t(2038) = 0.06, p = 0.955; Std.
## beta = 0.02, 95% CI [-0.78, 0.83])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.74, 95% CI [-10.10, 11.58], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.07, 95% CI [-0.94, 1.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.16, 95% CI [-9.40, 11.72], t(2038) = 0.21, p = 0.830; Std.
## beta = 0.11, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SS_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to
## SS_5yrPreDx = 0, is at 62.35 (95% CI [58.49, 66.22], t(2038) = 31.63, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.93, 95% CI [-6.30, -3.55], t(2038) = -7.04, p < .001; Std. beta = -0.38, 95%
## CI [-0.47, -0.30])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -13.37, 95% CI [-26.60, -0.15], t(2038) = -1.98, p = 0.047; Std. beta = -0.10,
## 95% CI [-0.25, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.67, 95% CI [-22.17, 65.50], t(2038) = 0.97, p = 0.332; Std. beta = -0.61,
## 95% CI [-3.83, 2.61])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.86, 95% CI [-10.70, 36.43], t(2038) = 1.07, p = 0.285; Std. beta = 0.91,
## 95% CI [-0.48, 2.30])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-19.71, 26.15], t(2038) = 0.28, p = 0.783; Std. beta = -0.23,
## 95% CI [-1.71, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.77, 95% CI [-31.80, 6.25], t(2038) = -1.32, p = 0.188; Std. beta = -0.78,
## 95% CI [-2.12, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.54, 95% CI [-3.79, 42.87], t(2038) = 1.64, p = 0.101; Std. beta = 0.90,
## 95% CI [-0.57, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.53, 95% CI [3.29, 21.77], t(2038) = 2.66, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.13, 0.97])
## - The effect of site [09R] is statistically significant and positive (beta =
## 24.15, 95% CI [0.96, 47.34], t(2038) = 2.04, p = 0.041; Std. beta = 0.83, 95%
## CI [-0.61, 2.27])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.26, 9.33], t(2038) = 0.94, p = 0.345; Std. beta = 0.12, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.39, 95% CI [-3.10, 21.88], t(2038) = 1.47, p = 0.141; Std. beta = 0.37, 95%
## CI [-0.38, 1.12])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.05, 5.85], t(2038) = 0.14, p = 0.886; Std. beta = 0.16, 95%
## CI [-0.17, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-17.78, 7.38], t(2038) = -0.81, p = 0.418; Std. beta = 0.23,
## 95% CI [-0.63, 1.09])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-1.60, 10.73], t(2038) = 1.45, p = 0.147; Std. beta = 0.25, 95%
## CI [-0.13, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-11.86, 4.46], t(2038) = -0.89, p = 0.374; Std. beta = -0.04,
## 95% CI [-0.53, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-27.71, 18.78], t(2038) = -0.38, p = 0.706; Std. beta = 0.38,
## 95% CI [-1.16, 1.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.07, 95% CI [-20.92, 16.77], t(2038) = -0.22, p = 0.829; Std. beta = 0.49,
## 95% CI [-0.64, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 22.18, 95% CI [-14.35, 58.70], t(2038) = 1.19, p = 0.234; Std. beta = 1.30,
## 95% CI [-0.84, 3.44])
## - The effect of site [11R] is statistically significant and positive (beta =
## 21.54, 95% CI [5.37, 37.70], t(2038) = 2.61, p = 0.009; Std. beta = 1.51, 95%
## CI [0.53, 2.50])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-12.96, 33.17], t(2038) = 0.86, p = 0.390; Std. beta = 0.59,
## 95% CI [-0.84, 2.03])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-1.43, 33.12], t(2038) = 1.80, p = 0.072; Std. beta = 0.78,
## 95% CI [-0.27, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.28, 95% CI [-21.06, 37.62], t(2038) = 0.55, p = 0.580; Std. beta = 0.73,
## 95% CI [-1.73, 3.19])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.61, 95% CI [-60.49, 5.26], t(2038) = -1.65, p = 0.100; Std. beta = -1.86,
## 95% CI [-4.17, 0.45])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -12.03, 95% CI [-26.94, 2.87], t(2038) = -1.58, p = 0.113; Std. beta = -0.55,
## 95% CI [-1.47, 0.37])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-28.05, 37.75], t(2038) = 0.29, p = 0.773; Std. beta = 0.28,
## 95% CI [-1.64, 2.21])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 4.74, 95% CI [-18.90, 28.39], t(2038) = 0.39, p = 0.694; Std. beta = 0.76,
## 95% CI [-1.29, 2.80])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-4.27, 22.82], t(2038) = 1.34, p = 0.180; Std. beta = 0.48, 95%
## CI [-0.38, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-11.17, 16.05], t(2038) = 0.35, p = 0.725; Std. beta = 0.24,
## 95% CI [-0.62, 1.11])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-27.70, 36.27], t(2038) = 0.26, p = 0.793; Std. beta = 0.62,
## 95% CI [-1.27, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.70, 95% CI [-7.64, 13.05], t(2038) = 0.51, p = 0.608; Std. beta = -0.18,
## 95% CI [-0.85, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -7.93, 95% CI [-22.99, 7.12], t(2038) = -1.03, p = 0.301; Std. beta = -0.42,
## 95% CI [-1.53, 0.69])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.20, 95% CI [-7.28, 17.69], t(2038) = 0.82, p = 0.414; Std. beta = 0.33, 95%
## CI [-0.43, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 19.14, 95% CI [-2.68, 40.95], t(2038) = 1.72, p = 0.086; Std. beta = 0.24,
## 95% CI [-1.07, 1.56])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-18.93, 19.27], t(2038) = 0.02, p = 0.986; Std. beta = -0.92,
## 95% CI [-2.90, 1.05])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-32.26, 33.37], t(2038) = 0.03, p = 0.974; Std. beta = -0.10,
## 95% CI [-2.02, 1.81])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.07, 95% CI [-10.44, 18.58], t(2038) = 0.55, p = 0.582; Std. beta = 0.31,
## 95% CI [-0.55, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.53, 95% CI [-3.85, 28.91], t(2038) = 1.50, p = 0.134; Std. beta = 0.38,
## 95% CI [-0.64, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-27.61, 6.54], t(2038) = -1.21, p = 0.227; Std. beta = -0.47,
## 95% CI [-1.59, 0.64])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.22, 14.66], t(2038) = 0.35, p = 0.727; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-12.68, 25.36], t(2038) = 0.65, p = 0.514; Std. beta = 1.37,
## 95% CI [0.19, 2.55])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-27.73, 1.66], t(2038) = -1.74, p = 0.082; Std. beta = -0.47,
## 95% CI [-1.39, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-3.32, 29.13], t(2038) = 1.56, p = 0.119; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.32, 95% CI [1.31, 23.33], t(2038) = 2.19, p = 0.028; Std. beta = 0.47, 95%
## CI [-0.19, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.52, 95% CI [-16.07, 49.11], t(2038) = 0.99, p = 0.320; Std. beta = -2.86,
## 95% CI [-4.97, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.25, 95% CI [7.24, 53.26], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.34, 3.25])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 1.05, 95% CI [-17.93, 20.03], t(2038) = 0.11, p = 0.913; Std. beta = 0.12,
## 95% CI [-1.16, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.68, 95% CI [-9.51, 10.87], t(2038) = 0.13, p = 0.896; Std. beta = 0.14, 95%
## CI [-0.78, 1.05])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.32, 95% CI [-1.48, 8.12], t(2038) = 1.36, p = 0.176;
## Std. beta = 0.06, 95% CI [-0.03, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -22.37, 95% CI [-53.17, 8.44], t(2038) = -1.42, p = 0.155;
## Std. beta = -2.09, 95% CI [-4.96, 0.79])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-7.95, 11.70], t(2038) = 0.37, p = 0.708; Std.
## beta = 0.17, 95% CI [-0.74, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.94, 95% CI [-15.71, 5.84], t(2038) = -0.90, p = 0.369; Std.
## beta = -0.46, 95% CI [-1.46, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-12.59, 11.80], t(2038) = -0.06, p = 0.949;
## Std. beta = -0.04, 95% CI [-1.17, 1.10])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-12.22, 6.47], t(2038) = -0.60, p = 0.546; Std.
## beta = -0.27, 95% CI [-1.14, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.80, 95% CI [-6.48, -1.12], t(2038) = -2.78, p = 0.005; Std.
## beta = -0.35, 95% CI [-0.60, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.95, 95% CI [-15.22, 1.32], t(2038) = -1.65, p = 0.099; Std.
## beta = -0.65, 95% CI [-1.42, 0.12])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-2.69, 1.42], t(2038) = -0.61, p = 0.543; Std.
## beta = -0.06, 95% CI [-0.25, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-6.21, 1.97], t(2038) = -1.02, p = 0.310; Std.
## beta = -0.20, 95% CI [-0.58, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-0.24, 3.55], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.15, 95% CI [-0.02, 0.33])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.35, 95% CI [-0.39, 13.09], t(2038) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.31, 1.79], t(2038) = -0.25, p = 0.802; Std.
## beta = -0.02, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-0.90, 5.22], t(2038) = 1.39, p = 0.166; Std.
## beta = 0.20, 95% CI [-0.08, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.59, 95% CI [-5.53, 20.71], t(2038) = 1.13, p = 0.257; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.22, 95% CI [1.23, 13.20], t(2038) = 2.36, p = 0.018; Std.
## beta = 0.67, 95% CI [0.11, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-2.44, 8.34], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.28, 95% CI [-0.23, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 7.33e-03, 95% CI [-7.93, 7.95], t(2038) = 1.81e-03, p = 0.999;
## Std. beta = 6.81e-04, 95% CI [-0.74, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-9.65, 5.99], t(2038) = -0.46, p = 0.646; Std.
## beta = -0.17, 95% CI [-0.90, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-34.24, 40.12], t(2038) = 0.16, p = 0.877; Std.
## beta = 0.27, 95% CI [-3.19, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-25.17, 19.43], t(2038) = -0.25, p = 0.801;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-3.31, 7.00], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.70, 95% CI [-15.48, 26.88], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.53, 95% CI [-1.44, 2.51])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-6.74, 5.12], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.08, 95% CI [-0.63, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-4.96, 7.37], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.11, 95% CI [-0.46, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-4.32, 13.15], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.41, 95% CI [-0.40, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.02, 95% CI [-9.26, 1.23], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.37, 95% CI [-0.86, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-9.35, 10.38], t(2038) = 0.10, p = 0.918; Std.
## beta = 0.05, 95% CI [-0.87, 0.97])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-4.24, 4.76], t(2038) = 0.11, p = 0.910; Std.
## beta = 0.02, 95% CI [-0.40, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -10.45, 95% CI [-18.22, -2.69], t(2038) = -2.64, p = 0.008;
## Std. beta = -0.97, 95% CI [-1.70, -0.25])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.11, 95% CI [-32.64, 10.42], t(2038) = -1.01, p = 0.312;
## Std. beta = -1.04, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-10.90, 7.68], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.15, 95% CI [-1.02, 0.72])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-2.93, 4.57], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.08, 95% CI [-0.27, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-10.63, 2.14], t(2038) = -1.30, p = 0.192; Std.
## beta = -0.40, 95% CI [-0.99, 0.20])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-6.02, 9.45], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.16, 95% CI [-0.56, 0.88])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-4.91, 4.13], t(2038) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.46, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.83, 95% CI [3.78, 19.88], t(2038) = 2.88, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.46, 95% CI [-2.04, 8.96], t(2038) = 1.23, p = 0.217; Std.
## beta = 0.32, 95% CI [-0.19, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-7.64, 2.96], t(2038) = -0.87, p = 0.387; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-6.53, 0.59], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.54, 95% CI [-62.30, -28.78], t(2038) = -5.33, p < .001;
## Std. beta = -4.25, 95% CI [-5.81, -2.68])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-8.40, 8.90], t(2038) = 0.06, p = 0.955; Std.
## beta = 0.02, 95% CI [-0.78, 0.83])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.74, 95% CI [-10.10, 11.58], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.07, 95% CI [-0.94, 1.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.16, 95% CI [-9.40, 11.72], t(2038) = 0.21, p = 0.830; Std.
## beta = 0.11, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT * site
## + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 62.35 (95% CI [58.49, 66.22], t(2038) = 31.63, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.93, 95% CI [-6.30, -3.55], t(2038) = -7.04, p < .001; Std. beta = -0.38, 95%
## CI [-0.47, -0.30])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -13.37, 95% CI [-26.60, -0.15], t(2038) = -1.98, p = 0.047; Std. beta = -0.10,
## 95% CI [-0.25, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.67, 95% CI [-22.17, 65.50], t(2038) = 0.97, p = 0.332; Std. beta = -0.61,
## 95% CI [-3.83, 2.61])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.86, 95% CI [-10.70, 36.43], t(2038) = 1.07, p = 0.285; Std. beta = 0.91,
## 95% CI [-0.48, 2.30])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-19.71, 26.15], t(2038) = 0.28, p = 0.783; Std. beta = -0.23,
## 95% CI [-1.71, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.77, 95% CI [-31.80, 6.25], t(2038) = -1.32, p = 0.188; Std. beta = -0.78,
## 95% CI [-2.12, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.54, 95% CI [-3.79, 42.87], t(2038) = 1.64, p = 0.101; Std. beta = 0.90,
## 95% CI [-0.57, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.53, 95% CI [3.29, 21.77], t(2038) = 2.66, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.13, 0.97])
## - The effect of site [09R] is statistically significant and positive (beta =
## 24.15, 95% CI [0.96, 47.34], t(2038) = 2.04, p = 0.041; Std. beta = 0.83, 95%
## CI [-0.61, 2.27])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.26, 9.33], t(2038) = 0.94, p = 0.345; Std. beta = 0.12, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.39, 95% CI [-3.10, 21.88], t(2038) = 1.47, p = 0.141; Std. beta = 0.37, 95%
## CI [-0.38, 1.12])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.05, 5.85], t(2038) = 0.14, p = 0.886; Std. beta = 0.16, 95%
## CI [-0.17, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-17.78, 7.38], t(2038) = -0.81, p = 0.418; Std. beta = 0.23,
## 95% CI [-0.63, 1.09])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-1.60, 10.73], t(2038) = 1.45, p = 0.147; Std. beta = 0.25, 95%
## CI [-0.13, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-11.86, 4.46], t(2038) = -0.89, p = 0.374; Std. beta = -0.04,
## 95% CI [-0.53, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-27.71, 18.78], t(2038) = -0.38, p = 0.706; Std. beta = 0.38,
## 95% CI [-1.16, 1.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.07, 95% CI [-20.92, 16.77], t(2038) = -0.22, p = 0.829; Std. beta = 0.49,
## 95% CI [-0.64, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 22.18, 95% CI [-14.35, 58.70], t(2038) = 1.19, p = 0.234; Std. beta = 1.30,
## 95% CI [-0.84, 3.44])
## - The effect of site [11R] is statistically significant and positive (beta =
## 21.54, 95% CI [5.37, 37.70], t(2038) = 2.61, p = 0.009; Std. beta = 1.51, 95%
## CI [0.53, 2.50])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-12.96, 33.17], t(2038) = 0.86, p = 0.390; Std. beta = 0.59,
## 95% CI [-0.84, 2.03])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-1.43, 33.12], t(2038) = 1.80, p = 0.072; Std. beta = 0.78,
## 95% CI [-0.27, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.28, 95% CI [-21.06, 37.62], t(2038) = 0.55, p = 0.580; Std. beta = 0.73,
## 95% CI [-1.73, 3.19])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.61, 95% CI [-60.49, 5.26], t(2038) = -1.65, p = 0.100; Std. beta = -1.86,
## 95% CI [-4.17, 0.45])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -12.03, 95% CI [-26.94, 2.87], t(2038) = -1.58, p = 0.113; Std. beta = -0.55,
## 95% CI [-1.47, 0.37])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-28.05, 37.75], t(2038) = 0.29, p = 0.773; Std. beta = 0.28,
## 95% CI [-1.64, 2.21])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 4.74, 95% CI [-18.90, 28.39], t(2038) = 0.39, p = 0.694; Std. beta = 0.76,
## 95% CI [-1.29, 2.80])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-4.27, 22.82], t(2038) = 1.34, p = 0.180; Std. beta = 0.48, 95%
## CI [-0.38, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-11.17, 16.05], t(2038) = 0.35, p = 0.725; Std. beta = 0.24,
## 95% CI [-0.62, 1.11])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-27.70, 36.27], t(2038) = 0.26, p = 0.793; Std. beta = 0.62,
## 95% CI [-1.27, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.70, 95% CI [-7.64, 13.05], t(2038) = 0.51, p = 0.608; Std. beta = -0.18,
## 95% CI [-0.85, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -7.93, 95% CI [-22.99, 7.12], t(2038) = -1.03, p = 0.301; Std. beta = -0.42,
## 95% CI [-1.53, 0.69])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.20, 95% CI [-7.28, 17.69], t(2038) = 0.82, p = 0.414; Std. beta = 0.33, 95%
## CI [-0.43, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 19.14, 95% CI [-2.68, 40.95], t(2038) = 1.72, p = 0.086; Std. beta = 0.24,
## 95% CI [-1.07, 1.56])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-18.93, 19.27], t(2038) = 0.02, p = 0.986; Std. beta = -0.92,
## 95% CI [-2.90, 1.05])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-32.26, 33.37], t(2038) = 0.03, p = 0.974; Std. beta = -0.10,
## 95% CI [-2.02, 1.81])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.07, 95% CI [-10.44, 18.58], t(2038) = 0.55, p = 0.582; Std. beta = 0.31,
## 95% CI [-0.55, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.53, 95% CI [-3.85, 28.91], t(2038) = 1.50, p = 0.134; Std. beta = 0.38,
## 95% CI [-0.64, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-27.61, 6.54], t(2038) = -1.21, p = 0.227; Std. beta = -0.47,
## 95% CI [-1.59, 0.64])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.22, 14.66], t(2038) = 0.35, p = 0.727; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-12.68, 25.36], t(2038) = 0.65, p = 0.514; Std. beta = 1.37,
## 95% CI [0.19, 2.55])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-27.73, 1.66], t(2038) = -1.74, p = 0.082; Std. beta = -0.47,
## 95% CI [-1.39, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-3.32, 29.13], t(2038) = 1.56, p = 0.119; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.32, 95% CI [1.31, 23.33], t(2038) = 2.19, p = 0.028; Std. beta = 0.47, 95%
## CI [-0.19, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.52, 95% CI [-16.07, 49.11], t(2038) = 0.99, p = 0.320; Std. beta = -2.86,
## 95% CI [-4.97, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.25, 95% CI [7.24, 53.26], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.34, 3.25])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 1.05, 95% CI [-17.93, 20.03], t(2038) = 0.11, p = 0.913; Std. beta = 0.12,
## 95% CI [-1.16, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.68, 95% CI [-9.51, 10.87], t(2038) = 0.13, p = 0.896; Std. beta = 0.14, 95%
## CI [-0.78, 1.05])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.32, 95% CI [-1.48, 8.12], t(2038) = 1.36, p = 0.176;
## Std. beta = 0.06, 95% CI [-0.03, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -22.37, 95% CI [-53.17, 8.44], t(2038) = -1.42, p = 0.155;
## Std. beta = -2.09, 95% CI [-4.96, 0.79])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-7.95, 11.70], t(2038) = 0.37, p = 0.708; Std.
## beta = 0.17, 95% CI [-0.74, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.94, 95% CI [-15.71, 5.84], t(2038) = -0.90, p = 0.369; Std.
## beta = -0.46, 95% CI [-1.46, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-12.59, 11.80], t(2038) = -0.06, p = 0.949;
## Std. beta = -0.04, 95% CI [-1.17, 1.10])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-12.22, 6.47], t(2038) = -0.60, p = 0.546; Std.
## beta = -0.27, 95% CI [-1.14, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.80, 95% CI [-6.48, -1.12], t(2038) = -2.78, p = 0.005; Std.
## beta = -0.35, 95% CI [-0.60, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.95, 95% CI [-15.22, 1.32], t(2038) = -1.65, p = 0.099; Std.
## beta = -0.65, 95% CI [-1.42, 0.12])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-2.69, 1.42], t(2038) = -0.61, p = 0.543; Std.
## beta = -0.06, 95% CI [-0.25, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-6.21, 1.97], t(2038) = -1.02, p = 0.310; Std.
## beta = -0.20, 95% CI [-0.58, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-0.24, 3.55], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.15, 95% CI [-0.02, 0.33])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.35, 95% CI [-0.39, 13.09], t(2038) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.31, 1.79], t(2038) = -0.25, p = 0.802; Std.
## beta = -0.02, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-0.90, 5.22], t(2038) = 1.39, p = 0.166; Std.
## beta = 0.20, 95% CI [-0.08, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.59, 95% CI [-5.53, 20.71], t(2038) = 1.13, p = 0.257; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.22, 95% CI [1.23, 13.20], t(2038) = 2.36, p = 0.018; Std.
## beta = 0.67, 95% CI [0.11, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-2.44, 8.34], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.28, 95% CI [-0.23, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 7.33e-03, 95% CI [-7.93, 7.95], t(2038) = 1.81e-03, p = 0.999;
## Std. beta = 6.81e-04, 95% CI [-0.74, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-9.65, 5.99], t(2038) = -0.46, p = 0.646; Std.
## beta = -0.17, 95% CI [-0.90, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-34.24, 40.12], t(2038) = 0.16, p = 0.877; Std.
## beta = 0.27, 95% CI [-3.19, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-25.17, 19.43], t(2038) = -0.25, p = 0.801;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-3.31, 7.00], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.70, 95% CI [-15.48, 26.88], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.53, 95% CI [-1.44, 2.51])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-6.74, 5.12], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.08, 95% CI [-0.63, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-4.96, 7.37], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.11, 95% CI [-0.46, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-4.32, 13.15], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.41, 95% CI [-0.40, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.02, 95% CI [-9.26, 1.23], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.37, 95% CI [-0.86, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-9.35, 10.38], t(2038) = 0.10, p = 0.918; Std.
## beta = 0.05, 95% CI [-0.87, 0.97])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-4.24, 4.76], t(2038) = 0.11, p = 0.910; Std.
## beta = 0.02, 95% CI [-0.40, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -10.45, 95% CI [-18.22, -2.69], t(2038) = -2.64, p = 0.008;
## Std. beta = -0.97, 95% CI [-1.70, -0.25])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.11, 95% CI [-32.64, 10.42], t(2038) = -1.01, p = 0.312;
## Std. beta = -1.04, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-10.90, 7.68], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.15, 95% CI [-1.02, 0.72])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-2.93, 4.57], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.08, 95% CI [-0.27, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-10.63, 2.14], t(2038) = -1.30, p = 0.192; Std.
## beta = -0.40, 95% CI [-0.99, 0.20])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-6.02, 9.45], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.16, 95% CI [-0.56, 0.88])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-4.91, 4.13], t(2038) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.46, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.83, 95% CI [3.78, 19.88], t(2038) = 2.88, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.46, 95% CI [-2.04, 8.96], t(2038) = 1.23, p = 0.217; Std.
## beta = 0.32, 95% CI [-0.19, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-7.64, 2.96], t(2038) = -0.87, p = 0.387; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-6.53, 0.59], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.54, 95% CI [-62.30, -28.78], t(2038) = -5.33, p < .001;
## Std. beta = -4.25, 95% CI [-5.81, -2.68])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-8.40, 8.90], t(2038) = 0.06, p = 0.955; Std.
## beta = 0.02, 95% CI [-0.78, 0.83])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.74, 95% CI [-10.10, 11.58], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.07, 95% CI [-0.94, 1.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.16, 95% CI [-9.40, 11.72], t(2038) = 0.21, p = 0.830; Std.
## beta = 0.11, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to cohort
## = CARE-PF, is at 62.35 (95% CI [58.49, 66.22], t(2038) = 31.63, p < .001).
## Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.93, 95% CI [-6.30, -3.55], t(2038) = -7.04, p < .001; Std. beta = -0.38, 95%
## CI [-0.47, -0.30])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -13.37, 95% CI [-26.60, -0.15], t(2038) = -1.98, p = 0.047; Std. beta = -0.10,
## 95% CI [-0.25, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.67, 95% CI [-22.17, 65.50], t(2038) = 0.97, p = 0.332; Std. beta = -0.61,
## 95% CI [-3.83, 2.61])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.86, 95% CI [-10.70, 36.43], t(2038) = 1.07, p = 0.285; Std. beta = 0.91,
## 95% CI [-0.48, 2.30])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-19.71, 26.15], t(2038) = 0.28, p = 0.783; Std. beta = -0.23,
## 95% CI [-1.71, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.77, 95% CI [-31.80, 6.25], t(2038) = -1.32, p = 0.188; Std. beta = -0.78,
## 95% CI [-2.12, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.54, 95% CI [-3.79, 42.87], t(2038) = 1.64, p = 0.101; Std. beta = 0.90,
## 95% CI [-0.57, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.53, 95% CI [3.29, 21.77], t(2038) = 2.66, p = 0.008; Std. beta = 0.42, 95%
## CI [-0.13, 0.97])
## - The effect of site [09R] is statistically significant and positive (beta =
## 24.15, 95% CI [0.96, 47.34], t(2038) = 2.04, p = 0.041; Std. beta = 0.83, 95%
## CI [-0.61, 2.27])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-3.26, 9.33], t(2038) = 0.94, p = 0.345; Std. beta = 0.12, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.39, 95% CI [-3.10, 21.88], t(2038) = 1.47, p = 0.141; Std. beta = 0.37, 95%
## CI [-0.38, 1.12])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.05, 5.85], t(2038) = 0.14, p = 0.886; Std. beta = 0.16, 95%
## CI [-0.17, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-17.78, 7.38], t(2038) = -0.81, p = 0.418; Std. beta = 0.23,
## 95% CI [-0.63, 1.09])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.56, 95% CI [-1.60, 10.73], t(2038) = 1.45, p = 0.147; Std. beta = 0.25, 95%
## CI [-0.13, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-11.86, 4.46], t(2038) = -0.89, p = 0.374; Std. beta = -0.04,
## 95% CI [-0.53, 0.46])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.46, 95% CI [-27.71, 18.78], t(2038) = -0.38, p = 0.706; Std. beta = 0.38,
## 95% CI [-1.16, 1.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.07, 95% CI [-20.92, 16.77], t(2038) = -0.22, p = 0.829; Std. beta = 0.49,
## 95% CI [-0.64, 1.61])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 22.18, 95% CI [-14.35, 58.70], t(2038) = 1.19, p = 0.234; Std. beta = 1.30,
## 95% CI [-0.84, 3.44])
## - The effect of site [11R] is statistically significant and positive (beta =
## 21.54, 95% CI [5.37, 37.70], t(2038) = 2.61, p = 0.009; Std. beta = 1.51, 95%
## CI [0.53, 2.50])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-12.96, 33.17], t(2038) = 0.86, p = 0.390; Std. beta = 0.59,
## 95% CI [-0.84, 2.03])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.85, 95% CI [-1.43, 33.12], t(2038) = 1.80, p = 0.072; Std. beta = 0.78,
## 95% CI [-0.27, 1.82])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.28, 95% CI [-21.06, 37.62], t(2038) = 0.55, p = 0.580; Std. beta = 0.73,
## 95% CI [-1.73, 3.19])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.61, 95% CI [-60.49, 5.26], t(2038) = -1.65, p = 0.100; Std. beta = -1.86,
## 95% CI [-4.17, 0.45])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -12.03, 95% CI [-26.94, 2.87], t(2038) = -1.58, p = 0.113; Std. beta = -0.55,
## 95% CI [-1.47, 0.37])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-28.05, 37.75], t(2038) = 0.29, p = 0.773; Std. beta = 0.28,
## 95% CI [-1.64, 2.21])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 4.74, 95% CI [-18.90, 28.39], t(2038) = 0.39, p = 0.694; Std. beta = 0.76,
## 95% CI [-1.29, 2.80])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-4.27, 22.82], t(2038) = 1.34, p = 0.180; Std. beta = 0.48, 95%
## CI [-0.38, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-11.17, 16.05], t(2038) = 0.35, p = 0.725; Std. beta = 0.24,
## 95% CI [-0.62, 1.11])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-27.70, 36.27], t(2038) = 0.26, p = 0.793; Std. beta = 0.62,
## 95% CI [-1.27, 2.51])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.70, 95% CI [-7.64, 13.05], t(2038) = 0.51, p = 0.608; Std. beta = -0.18,
## 95% CI [-0.85, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -7.93, 95% CI [-22.99, 7.12], t(2038) = -1.03, p = 0.301; Std. beta = -0.42,
## 95% CI [-1.53, 0.69])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.20, 95% CI [-7.28, 17.69], t(2038) = 0.82, p = 0.414; Std. beta = 0.33, 95%
## CI [-0.43, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 19.14, 95% CI [-2.68, 40.95], t(2038) = 1.72, p = 0.086; Std. beta = 0.24,
## 95% CI [-1.07, 1.56])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-18.93, 19.27], t(2038) = 0.02, p = 0.986; Std. beta = -0.92,
## 95% CI [-2.90, 1.05])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-32.26, 33.37], t(2038) = 0.03, p = 0.974; Std. beta = -0.10,
## 95% CI [-2.02, 1.81])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.07, 95% CI [-10.44, 18.58], t(2038) = 0.55, p = 0.582; Std. beta = 0.31,
## 95% CI [-0.55, 1.16])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.53, 95% CI [-3.85, 28.91], t(2038) = 1.50, p = 0.134; Std. beta = 0.38,
## 95% CI [-0.64, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-27.61, 6.54], t(2038) = -1.21, p = 0.227; Std. beta = -0.47,
## 95% CI [-1.59, 0.64])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.22, 14.66], t(2038) = 0.35, p = 0.727; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-12.68, 25.36], t(2038) = 0.65, p = 0.514; Std. beta = 1.37,
## 95% CI [0.19, 2.55])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-27.73, 1.66], t(2038) = -1.74, p = 0.082; Std. beta = -0.47,
## 95% CI [-1.39, 0.44])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.90, 95% CI [-3.32, 29.13], t(2038) = 1.56, p = 0.119; Std. beta = 0.56,
## 95% CI [-0.42, 1.54])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.32, 95% CI [1.31, 23.33], t(2038) = 2.19, p = 0.028; Std. beta = 0.47, 95%
## CI [-0.19, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.52, 95% CI [-16.07, 49.11], t(2038) = 0.99, p = 0.320; Std. beta = -2.86,
## 95% CI [-4.97, -0.75])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.25, 95% CI [7.24, 53.26], t(2038) = 2.58, p = 0.010; Std. beta = 1.79, 95%
## CI [0.34, 3.25])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 1.05, 95% CI [-17.93, 20.03], t(2038) = 0.11, p = 0.913; Std. beta = 0.12,
## 95% CI [-1.16, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.68, 95% CI [-9.51, 10.87], t(2038) = 0.13, p = 0.896; Std. beta = 0.14, 95%
## CI [-0.78, 1.05])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.32, 95% CI [-1.48, 8.12], t(2038) = 1.36, p = 0.176;
## Std. beta = 0.06, 95% CI [-0.03, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -22.37, 95% CI [-53.17, 8.44], t(2038) = -1.42, p = 0.155;
## Std. beta = -2.09, 95% CI [-4.96, 0.79])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-7.95, 11.70], t(2038) = 0.37, p = 0.708; Std.
## beta = 0.17, 95% CI [-0.74, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.94, 95% CI [-15.71, 5.84], t(2038) = -0.90, p = 0.369; Std.
## beta = -0.46, 95% CI [-1.46, 0.54])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-12.59, 11.80], t(2038) = -0.06, p = 0.949;
## Std. beta = -0.04, 95% CI [-1.17, 1.10])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-12.22, 6.47], t(2038) = -0.60, p = 0.546; Std.
## beta = -0.27, 95% CI [-1.14, 0.60])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.80, 95% CI [-6.48, -1.12], t(2038) = -2.78, p = 0.005; Std.
## beta = -0.35, 95% CI [-0.60, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.95, 95% CI [-15.22, 1.32], t(2038) = -1.65, p = 0.099; Std.
## beta = -0.65, 95% CI [-1.42, 0.12])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-2.69, 1.42], t(2038) = -0.61, p = 0.543; Std.
## beta = -0.06, 95% CI [-0.25, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-6.21, 1.97], t(2038) = -1.02, p = 0.310; Std.
## beta = -0.20, 95% CI [-0.58, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-0.24, 3.55], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.15, 95% CI [-0.02, 0.33])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.35, 95% CI [-0.39, 13.09], t(2038) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.31, 1.79], t(2038) = -0.25, p = 0.802; Std.
## beta = -0.02, 95% CI [-0.22, 0.17])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-0.90, 5.22], t(2038) = 1.39, p = 0.166; Std.
## beta = 0.20, 95% CI [-0.08, 0.49])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.59, 95% CI [-5.53, 20.71], t(2038) = 1.13, p = 0.257; Std.
## beta = 0.71, 95% CI [-0.52, 1.93])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.22, 95% CI [1.23, 13.20], t(2038) = 2.36, p = 0.018; Std.
## beta = 0.67, 95% CI [0.11, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-2.44, 8.34], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.28, 95% CI [-0.23, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 7.33e-03, 95% CI [-7.93, 7.95], t(2038) = 1.81e-03, p = 0.999;
## Std. beta = 6.81e-04, 95% CI [-0.74, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-9.65, 5.99], t(2038) = -0.46, p = 0.646; Std.
## beta = -0.17, 95% CI [-0.90, 0.56])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-34.24, 40.12], t(2038) = 0.16, p = 0.877; Std.
## beta = 0.27, 95% CI [-3.19, 3.74])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-25.17, 19.43], t(2038) = -0.25, p = 0.801;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-3.31, 7.00], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.17, 95% CI [-0.31, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.70, 95% CI [-15.48, 26.88], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.53, 95% CI [-1.44, 2.51])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-6.74, 5.12], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.08, 95% CI [-0.63, 0.48])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-4.96, 7.37], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.11, 95% CI [-0.46, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.42, 95% CI [-4.32, 13.15], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.41, 95% CI [-0.40, 1.23])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.02, 95% CI [-9.26, 1.23], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.37, 95% CI [-0.86, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.52, 95% CI [-9.35, 10.38], t(2038) = 0.10, p = 0.918; Std.
## beta = 0.05, 95% CI [-0.87, 0.97])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-4.24, 4.76], t(2038) = 0.11, p = 0.910; Std.
## beta = 0.02, 95% CI [-0.40, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -10.45, 95% CI [-18.22, -2.69], t(2038) = -2.64, p = 0.008;
## Std. beta = -0.97, 95% CI [-1.70, -0.25])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.11, 95% CI [-32.64, 10.42], t(2038) = -1.01, p = 0.312;
## Std. beta = -1.04, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-10.90, 7.68], t(2038) = -0.34, p = 0.734; Std.
## beta = -0.15, 95% CI [-1.02, 0.72])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-2.93, 4.57], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.08, 95% CI [-0.27, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-10.63, 2.14], t(2038) = -1.30, p = 0.192; Std.
## beta = -0.40, 95% CI [-0.99, 0.20])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-6.02, 9.45], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.16, 95% CI [-0.56, 0.88])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-4.91, 4.13], t(2038) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.46, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.83, 95% CI [3.78, 19.88], t(2038) = 2.88, p = 0.004; Std.
## beta = 1.10, 95% CI [0.35, 1.85])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.46, 95% CI [-2.04, 8.96], t(2038) = 1.23, p = 0.217; Std.
## beta = 0.32, 95% CI [-0.19, 0.84])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-7.64, 2.96], t(2038) = -0.87, p = 0.387; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-6.53, 0.59], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.28, 95% CI [-0.61, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.54, 95% CI [-62.30, -28.78], t(2038) = -5.33, p < .001;
## Std. beta = -4.25, 95% CI [-5.81, -2.68])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-8.40, 8.90], t(2038) = 0.06, p = 0.955; Std.
## beta = 0.02, 95% CI [-0.78, 0.83])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.74, 95% CI [-10.10, 11.58], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.07, 95% CI [-0.94, 1.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.16, 95% CI [-9.40, 11.72], t(2038) = 0.21, p = 0.830; Std.
## beta = 0.11, 95% CI [-0.88, 1.09])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*SS_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT * disadv +
## time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14176.9
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2845 -0.4396 -0.0111 0.4495 4.5301
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 230.72 15.189
## time_firstPFT 13.44 3.666 -0.07
## Residual 25.77 5.077
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 33.99033 6.20154 5.481
## time_firstPFT -2.22650 2.28349 -0.975
## SS_5yrPreDx -9.92030 6.64768 -1.492
## disadv 3.64929 2.87717 1.268
## dich_RaceNon-White -6.87947 2.79365 -2.463
## sexF 3.79577 1.75190 2.167
## age_dx 0.38738 0.09100 4.257
## smokeHxFormer 3.86845 1.72621 2.241
## smokeHxAlways 17.64226 8.40095 2.100
## smokeHxUnknown -1.91077 3.92177 -0.487
## site02R 10.48478 21.71795 0.483
## site03R 11.33658 11.66846 0.972
## site04R 3.03492 11.21572 0.271
## site05R -13.64384 9.34859 -1.459
## site06R 10.07800 16.09006 0.626
## site07R 11.48379 4.56401 2.516
## site09R 22.10737 11.39074 1.941
## site101 4.13871 3.13659 1.319
## site102 11.02487 6.20125 1.778
## site103 -0.34697 2.82862 -0.123
## site104 -6.87666 6.20354 -1.109
## site105 4.45716 3.07344 1.450
## site106 -5.44862 4.09431 -1.331
## site107 -1.87718 11.41626 -0.164
## site108 2.83127 9.65367 0.293
## site10R 16.18981 18.33712 0.883
## site11R 18.12921 7.93923 2.283
## site12R 6.04842 11.28977 0.536
## site13R 17.32337 8.54233 2.028
## site14R 6.74045 14.62479 0.461
## site15R -34.04599 16.15041 -2.108
## site16R -6.89562 7.39569 -0.932
## site17R 9.25444 16.27101 0.569
## site18R -0.08680 11.66432 -0.007
## site19R 8.44267 6.67094 1.266
## site20R 1.34414 6.68994 0.201
## site21R 2.82443 15.61169 0.181
## site22R -1.53008 5.17409 -0.296
## site23R -11.54335 8.85290 -1.304
## site24R 4.15519 6.12425 0.678
## site25R 13.52465 10.91654 1.239
## site28R 3.74547 9.41339 0.398
## site29R -3.26646 16.10209 -0.203
## site31R 5.12716 7.17813 0.714
## site32R 9.64721 8.06733 1.196
## site33R -10.31238 8.42940 -1.223
## site34R -0.21057 6.09950 -0.035
## site35R -0.29936 9.35685 -0.032
## site36R -11.81360 7.22171 -1.636
## site37R 15.59779 8.04289 1.939
## site38R 12.21590 5.40231 2.261
## site39R 21.78689 16.24366 1.341
## site40R 27.08713 11.29535 2.398
## site41R -1.85126 9.35938 -0.198
## site42R -0.29649 5.07683 -0.058
## time_firstPFT:SS_5yrPreDx 3.08831 2.56668 1.203
## time_firstPFT:disadv -0.21009 1.09819 -0.191
## time_firstPFT:dich_RaceNon-White -0.08273 1.12598 -0.073
## time_firstPFT:sexF -0.13060 0.66663 -0.196
## time_firstPFT:age_dx -0.05081 0.03481 -1.460
## time_firstPFT:smokeHxFormer 0.34391 0.67136 0.512
## time_firstPFT:smokeHxAlways 1.54824 5.30941 0.292
## time_firstPFT:smokeHxUnknown 1.39769 1.68216 0.831
## time_firstPFT:site02R -21.28301 15.86230 -1.342
## time_firstPFT:site03R 2.92304 5.09553 0.574
## time_firstPFT:site04R -4.62421 5.58963 -0.827
## time_firstPFT:site05R -0.11982 6.26838 -0.019
## time_firstPFT:site07R -3.42144 1.43670 -2.381
## time_firstPFT:site09R -6.77315 4.33434 -1.563
## time_firstPFT:site101 -0.47933 1.08803 -0.441
## time_firstPFT:site102 -2.25724 2.15623 -1.047
## time_firstPFT:site103 1.92030 1.03191 1.861
## time_firstPFT:site104 6.88562 3.53536 1.948
## time_firstPFT:site105 -0.20442 1.08092 -0.189
## time_firstPFT:site106 2.68103 1.63107 1.644
## time_firstPFT:site107 7.59935 6.73950 1.128
## time_firstPFT:site108 7.42412 3.32755 2.231
## time_firstPFT:site11R 3.70926 2.86090 1.297
## time_firstPFT:site12R 0.35811 4.15989 0.086
## time_firstPFT:site13R -1.48853 4.08211 -0.365
## time_firstPFT:site14R 3.30937 19.00273 0.174
## time_firstPFT:site15R -2.46862 11.42820 -0.216
## time_firstPFT:site16R 1.64945 2.73680 0.603
## time_firstPFT:site18R 6.31307 10.85333 0.582
## time_firstPFT:site19R -0.08715 3.10599 -0.028
## time_firstPFT:site20R 1.80596 3.22608 0.560
## time_firstPFT:site21R 4.57817 4.55143 1.006
## time_firstPFT:site22R -3.22554 2.76899 -1.165
## time_firstPFT:site23R 8.07379 24.74103 0.326
## time_firstPFT:site24R 0.31062 2.34111 0.133
## time_firstPFT:site25R -9.51452 4.13258 -2.302
## time_firstPFT:site28R -9.40020 11.10491 -0.846
## time_firstPFT:site29R -1.06649 4.87556 -0.219
## time_firstPFT:site31R 0.95628 2.00679 0.477
## time_firstPFT:site32R -3.54746 3.34014 -1.062
## time_firstPFT:site33R 2.26519 4.10524 0.552
## time_firstPFT:site34R -0.15718 2.38149 -0.066
## time_firstPFT:site35R 12.66975 4.20456 3.013
## time_firstPFT:site36R 3.68579 2.87590 1.282
## time_firstPFT:site37R -1.72989 2.84304 -0.608
## time_firstPFT:site38R -2.73998 1.86194 -1.472
## time_firstPFT:site39R -45.63861 8.69641 -5.248
## time_firstPFT:site40R 1.17661 4.55365 0.258
## time_firstPFT:site41R 1.52178 5.58775 0.272
## time_firstPFT:site42R 1.97844 5.41096 0.366##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.916
## Unadjusted ICC: 0.689report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SS_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 33.99 (95% CI [21.83, 46.15], t(2008)
## = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SS_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to SS_5yrPreDx = 0, is at 33.99 (95% CI
## [21.83, 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 33.99 (95% CI [21.83,
## 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to dich_Race = White, is at 33.99 (95% CI
## [21.83, 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 33.99 (95% CI [21.83,
## 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 33.99 (95% CI [21.83,
## 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 33.99 (95% CI
## [21.83, 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 33.99 (95% CI [21.83,
## 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to cohort = CARE-PF, is at 33.99 (95% CI
## [21.83, 46.15], t(2008) = 5.48, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.23, 95% CI [-6.70, 2.25], t(2008) = -0.98, p = 0.330; Std. beta =
## -0.43, 95% CI [-0.57, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.92, 95% CI [-22.96, 3.12], t(2008) = -1.49, p = 0.136; Std. beta = -0.06,
## 95% CI [-0.22, 0.09])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.65, 95% CI [-1.99, 9.29], t(2008) = 1.27, p = 0.205; Std. beta = 0.06, 95% CI
## [-0.05, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.88, 95% CI [-12.36, -1.40], t(2008) = -2.46, p = 0.014; Std. beta =
## -0.41, 95% CI [-0.76, -0.06])
## - The effect of sex [F] is statistically significant and positive (beta = 3.80,
## 95% CI [0.36, 7.23], t(2008) = 2.17, p = 0.030; Std. beta = 0.21, 95% CI
## [-3.56e-03, 0.43])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2008) = 4.26, p < .001; Std. beta = 0.17, 95% CI [0.07,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.87, 95% CI [0.48, 7.25], t(2008) = 2.24, p = 0.025; Std. beta = 0.26,
## 95% CI [0.04, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 17.64, 95% CI [1.17, 34.12], t(2008) = 2.10, p = 0.036; Std. beta =
## 1.16, 95% CI [-9.12e-03, 2.34])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.91, 95% CI [-9.60, 5.78], t(2008) = -0.49, p = 0.626; Std. beta =
## 5.97e-03, 95% CI [-0.49, 0.50])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-32.11, 53.08], t(2008) = 0.48, p = 0.629; Std. beta = -1.18,
## 95% CI [-4.39, 2.02])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.34, 95% CI [-11.55, 34.22], t(2008) = 0.97, p = 0.331; Std. beta = 0.91,
## 95% CI [-0.46, 2.28])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-18.96, 25.03], t(2008) = 0.27, p = 0.787; Std. beta = -0.21,
## 95% CI [-1.67, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.64, 95% CI [-31.98, 4.69], t(2008) = -1.46, p = 0.145; Std. beta = -0.81,
## 95% CI [-2.13, 0.51])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.08, 95% CI [-21.48, 41.63], t(2008) = 0.63, p = 0.531; Std. beta = 0.59,
## 95% CI [-1.26, 2.44])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.48, 95% CI [2.53, 20.43], t(2008) = 2.52, p = 0.012; Std. beta = 0.38, 95%
## CI [-0.16, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.11, 95% CI [-0.23, 44.45], t(2008) = 1.94, p = 0.052; Std. beta = 0.72,
## 95% CI [-0.69, 2.14])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-2.01, 10.29], t(2008) = 1.32, p = 0.187; Std. beta = 0.20, 95%
## CI [-0.18, 0.58])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-1.14, 23.19], t(2008) = 1.78, p = 0.076; Std. beta = 0.46,
## 95% CI [-0.29, 1.20])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.35, 95% CI [-5.89, 5.20], t(2008) = -0.12, p = 0.902; Std. beta = 0.14,
## 95% CI [-0.20, 0.49])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.88, 95% CI [-19.04, 5.29], t(2008) = -1.11, p = 0.268; Std. beta = 0.18,
## 95% CI [-0.68, 1.03])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-1.57, 10.48], t(2008) = 1.45, p = 0.147; Std. beta = 0.24, 95%
## CI [-0.13, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-13.48, 2.58], t(2008) = -1.33, p = 0.183; Std. beta = -0.09,
## 95% CI [-0.59, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-24.27, 20.51], t(2008) = -0.16, p = 0.869; Std. beta = 0.53,
## 95% CI [-0.98, 2.04])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.83, 95% CI [-16.10, 21.76], t(2008) = 0.29, p = 0.769; Std. beta = 0.79,
## 95% CI [-0.36, 1.94])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 16.19, 95% CI [-19.77, 52.15], t(2008) = 0.88, p = 0.377; Std. beta = 0.95,
## 95% CI [-1.16, 3.06])
## - The effect of site [11R] is statistically significant and positive (beta =
## 18.13, 95% CI [2.56, 33.70], t(2008) = 2.28, p = 0.023; Std. beta = 1.38, 95%
## CI [0.41, 2.34])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.05, 95% CI [-16.09, 28.19], t(2008) = 0.54, p = 0.592; Std. beta = 0.38,
## 95% CI [-1.02, 1.79])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.32, 95% CI [0.57, 34.08], t(2008) = 2.03, p = 0.043; Std. beta = 0.89, 95%
## CI [-0.14, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.74, 95% CI [-21.94, 35.42], t(2008) = 0.46, p = 0.645; Std. beta = 0.67,
## 95% CI [-1.78, 3.13])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.05, 95% CI [-65.72, -2.37], t(2008) = -2.11, p = 0.035; Std. beta = -2.20,
## 95% CI [-4.48, 0.07])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-21.40, 7.61], t(2008) = -0.93, p = 0.351; Std. beta = -0.26,
## 95% CI [-1.18, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.25, 95% CI [-22.66, 41.16], t(2008) = 0.57, p = 0.570; Std. beta = 0.54,
## 95% CI [-1.33, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.09, 95% CI [-22.96, 22.79], t(2008) = -7.44e-03, p = 0.994; Std. beta =
## 0.53, 95% CI [-1.51, 2.56])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-4.64, 21.53], t(2008) = 1.27, p = 0.206; Std. beta = 0.49, 95%
## CI [-0.36, 1.33])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.78, 14.46], t(2008) = 0.20, p = 0.841; Std. beta = 0.23,
## 95% CI [-0.62, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-27.79, 33.44], t(2008) = 0.18, p = 0.856; Std. beta = 0.55,
## 95% CI [-1.28, 2.39])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-11.68, 8.62], t(2008) = -0.30, p = 0.767; Std. beta = -0.36,
## 95% CI [-1.03, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-28.91, 5.82], t(2008) = -1.30, p = 0.192; Std. beta =
## 4.81e-03, 95% CI [-3.82, 3.83])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.86, 16.17], t(2008) = 0.68, p = 0.498; Std. beta = 0.27, 95%
## CI [-0.47, 1.01])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 13.52, 95% CI [-7.88, 34.93], t(2008) = 1.24, p = 0.216; Std. beta = -0.01,
## 95% CI [-1.32, 1.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-14.72, 22.21], t(2008) = 0.40, p = 0.691; Std. beta = -0.57,
## 95% CI [-2.56, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-34.85, 28.31], t(2008) = -0.20, p = 0.839; Std. beta = -0.28,
## 95% CI [-2.15, 1.59])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-8.95, 19.20], t(2008) = 0.71, p = 0.475; Std. beta = 0.38, 95%
## CI [-0.46, 1.23])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-6.17, 25.47], t(2008) = 1.20, p = 0.232; Std. beta = 0.27, 95%
## CI [-0.73, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-26.84, 6.22], t(2008) = -1.22, p = 0.221; Std. beta = -0.41,
## 95% CI [-1.52, 0.70])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-12.17, 11.75], t(2008) = -0.03, p = 0.972; Std. beta = -0.03,
## 95% CI [-0.77, 0.72])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-18.65, 18.05], t(2008) = -0.03, p = 0.974; Std. beta = 1.05,
## 95% CI [-0.11, 2.21])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.81, 95% CI [-25.98, 2.35], t(2008) = -1.64, p = 0.102; Std. beta = -0.38,
## 95% CI [-1.28, 0.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.60, 95% CI [-0.18, 31.37], t(2008) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.20, 1.73])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.22, 95% CI [1.62, 22.81], t(2008) = 2.26, p = 0.024; Std. beta = 0.48, 95%
## CI [-0.16, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-10.07, 53.64], t(2008) = 1.34, p = 0.180; Std. beta = -2.58,
## 95% CI [-4.68, -0.47])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.09, 95% CI [4.94, 49.24], t(2008) = 2.40, p = 0.017; Std. beta = 1.69, 95%
## CI [0.26, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -1.85, 95% CI [-20.21, 16.50], t(2008) = -0.20, p = 0.843; Std. beta = 0.02,
## 95% CI [-1.25, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-10.25, 9.66], t(2008) = -0.06, p = 0.953; Std. beta = 0.15,
## 95% CI [-0.77, 1.07])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.09, 95% CI [-1.95, 8.12], t(2008) = 1.20, p = 0.229;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.36, 1.94], t(2008) = -0.19, p = 0.848; Std.
## beta = -5.62e-03, 95% CI [-0.06, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.08, 95% CI [-2.29, 2.13], t(2008) =
## -0.07, p = 0.941; Std. beta = -7.73e-03, 95% CI [-0.21, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-1.44, 1.18], t(2008) = -0.20, p = 0.845; Std.
## beta = -0.01, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.02], t(2008) = -1.46, p = 0.145; Std.
## beta = -0.04, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.34, 95% CI [-0.97, 1.66], t(2008) =
## 0.51, p = 0.609; Std. beta = 0.03, 95% CI [-0.09, 0.16])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.55, 95% CI [-8.86, 11.96], t(2008) =
## 0.29, p = 0.771; Std. beta = 0.14, 95% CI [-0.83, 1.12])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.40, 95% CI [-1.90, 4.70], t(2008) =
## 0.83, p = 0.406; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -21.28, 95% CI [-52.39, 9.83], t(2008) = -1.34, p = 0.180;
## Std. beta = -1.99, 95% CI [-4.90, 0.92])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.92, 95% CI [-7.07, 12.92], t(2008) = 0.57, p = 0.566; Std.
## beta = 0.27, 95% CI [-0.66, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.62, 95% CI [-15.59, 6.34], t(2008) = -0.83, p = 0.408; Std.
## beta = -0.43, 95% CI [-1.46, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-12.41, 12.17], t(2008) = -0.02, p = 0.985;
## Std. beta = -0.01, 95% CI [-1.16, 1.14])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.24, -0.60], t(2008) = -2.38, p = 0.017; Std.
## beta = -0.32, 95% CI [-0.58, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.77, 95% CI [-15.27, 1.73], t(2008) = -1.56, p = 0.118; Std.
## beta = -0.63, 95% CI [-1.43, 0.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-2.61, 1.65], t(2008) = -0.44, p = 0.660; Std.
## beta = -0.04, 95% CI [-0.24, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-6.49, 1.97], t(2008) = -1.05, p = 0.295; Std.
## beta = -0.21, 95% CI [-0.61, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-0.10, 3.94], t(2008) = 1.86, p = 0.063; Std.
## beta = 0.18, 95% CI [-9.66e-03, 0.37])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.05, 13.82], t(2008) = 1.95, p = 0.052; Std.
## beta = 0.64, 95% CI [-4.47e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-2.32, 1.92], t(2008) = -0.19, p = 0.850; Std.
## beta = -0.02, 95% CI [-0.22, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.68, 95% CI [-0.52, 5.88], t(2008) = 1.64, p = 0.100; Std.
## beta = 0.25, 95% CI [-0.05, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.60, 95% CI [-5.62, 20.82], t(2008) = 1.13, p = 0.260; Std.
## beta = 0.71, 95% CI [-0.52, 1.95])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.42, 95% CI [0.90, 13.95], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.69, 95% CI [0.08, 1.30])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-1.90, 9.32], t(2008) = 1.30, p = 0.195; Std.
## beta = 0.35, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-7.80, 8.52], t(2008) = 0.09, p = 0.931; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.49, 95% CI [-9.49, 6.52], t(2008) = -0.36, p = 0.715; Std.
## beta = -0.14, 95% CI [-0.89, 0.61])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-33.96, 40.58], t(2008) = 0.17, p = 0.862; Std.
## beta = 0.31, 95% CI [-3.17, 3.79])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-24.88, 19.94], t(2008) = -0.22, p = 0.829;
## Std. beta = -0.23, 95% CI [-2.32, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.72, 7.02], t(2008) = 0.60, p = 0.547; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.31, 95% CI [-14.97, 27.60], t(2008) = 0.58, p = 0.561; Std.
## beta = 0.59, 95% CI [-1.40, 2.58])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-6.18, 6.00], t(2008) = -0.03, p = 0.978; Std.
## beta = -8.14e-03, 95% CI [-0.58, 0.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-4.52, 8.13], t(2008) = 0.56, p = 0.576; Std.
## beta = 0.17, 95% CI [-0.42, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-4.35, 13.50], t(2008) = 1.01, p = 0.315; Std.
## beta = 0.43, 95% CI [-0.41, 1.26])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.23, 95% CI [-8.66, 2.20], t(2008) = -1.16, p = 0.244; Std.
## beta = -0.30, 95% CI [-0.81, 0.21])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.07, 95% CI [-40.45, 56.59], t(2008) = 0.33, p = 0.744; Std.
## beta = 0.75, 95% CI [-3.78, 5.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.31, 95% CI [-4.28, 4.90], t(2008) = 0.13, p = 0.894; Std.
## beta = 0.03, 95% CI [-0.40, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -9.51, 95% CI [-17.62, -1.41], t(2008) = -2.30, p = 0.021;
## Std. beta = -0.89, 95% CI [-1.65, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-31.18, 12.38], t(2008) = -0.85, p = 0.397;
## Std. beta = -0.88, 95% CI [-2.91, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-10.63, 8.50], t(2008) = -0.22, p = 0.827; Std.
## beta = -0.10, 95% CI [-0.99, 0.79])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-2.98, 4.89], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.09, 95% CI [-0.28, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-10.10, 3.00], t(2008) = -1.06, p = 0.288; Std.
## beta = -0.33, 95% CI [-0.94, 0.28])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.79, 10.32], t(2008) = 0.55, p = 0.581; Std.
## beta = 0.21, 95% CI [-0.54, 0.96])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.83, 4.51], t(2008) = -0.07, p = 0.947; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.67, 95% CI [4.42, 20.92], t(2008) = 3.01, p = 0.003; Std.
## beta = 1.18, 95% CI [0.41, 1.95])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.69, 95% CI [-1.95, 9.33], t(2008) = 1.28, p = 0.200; Std.
## beta = 0.34, 95% CI [-0.18, 0.87])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-7.31, 3.85], t(2008) = -0.61, p = 0.543; Std.
## beta = -0.16, 95% CI [-0.68, 0.36])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.39, 0.91], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.26, 95% CI [-0.60, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.64, 95% CI [-62.69, -28.58], t(2008) = -5.25, p < .001;
## Std. beta = -4.26, 95% CI [-5.86, -2.67])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-7.75, 10.11], t(2008) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.72, 0.94])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-9.44, 12.48], t(2008) = 0.27, p = 0.785; Std.
## beta = 0.14, 95% CI [-0.88, 1.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-8.63, 12.59], t(2008) = 0.37, p = 0.715; Std.
## beta = 0.18, 95% CI [-0.81, 1.18])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*Soil_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14370.4
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3029 -0.4348 -0.0160 0.4478 4.5318
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 255.42 15.982
## time_firstPFT 12.95 3.599 -0.10
## Residual 25.71 5.070
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 56.86578 3.26092 17.439
## time_firstPFT -5.06357 1.29941 -3.897
## Soil_5yrPreDx 5.05335 5.91162 0.855
## site02R -7.14252 16.80165 -0.425
## site03R 11.91255 12.22983 0.974
## site04R 3.52228 11.73263 0.300
## site05R -10.79647 9.69988 -1.113
## site06R 19.30880 11.97290 1.613
## site07R 13.58137 4.80433 2.827
## site09R 22.99821 11.88623 1.935
## site101 4.15532 3.36734 1.234
## site102 11.83786 6.36599 1.860
## site103 0.50345 3.10552 0.162
## site104 -3.66356 6.72589 -0.545
## site105 5.69360 3.36139 1.694
## site106 -3.43039 4.18796 -0.819
## site107 -3.79459 11.94409 -0.318
## site108 1.17585 9.59602 0.123
## site10R 9.97513 17.92446 0.557
## site11R 19.29715 8.39764 2.298
## site12R 11.90661 11.76955 1.012
## site13R 16.88870 8.88738 1.900
## site14R 8.64566 15.09006 0.573
## site15R -27.84549 16.82049 -1.655
## site16R -14.34770 7.50972 -1.911
## site17R 5.39718 16.83118 0.321
## site18R -1.10531 12.08987 -0.091
## site19R 5.32841 8.84081 0.603
## site20R 2.55861 7.07396 0.362
## site21R 3.53299 16.38315 0.216
## site22R 2.68589 5.46862 0.491
## site23R -13.58789 8.44614 -1.609
## site24R 6.52432 6.38104 1.022
## site25R 2.34330 6.95731 0.337
## site28R 0.96091 9.76382 0.098
## site29R -2.14151 16.74258 -0.128
## site31R 5.02775 7.47466 0.673
## site32R 4.06300 12.70986 0.320
## site33R -19.38031 9.46397 -2.048
## site34R 3.62871 6.47382 0.561
## site35R 7.31522 9.81740 0.745
## site36R -12.39477 7.50762 -1.651
## site37R 13.85273 8.35140 1.659
## site38R 13.20763 5.67045 2.329
## site39R 17.76066 16.67427 1.065
## site40R 27.20609 11.87513 2.291
## site41R -0.20967 9.68502 -0.022
## site42R 0.65023 5.29262 0.123
## time_firstPFT:Soil_5yrPreDx 1.59202 2.29596 0.693
## time_firstPFT:site02R -14.82904 14.75376 -1.005
## time_firstPFT:site03R 0.93872 5.10178 0.184
## time_firstPFT:site04R -4.82351 5.51684 -0.874
## time_firstPFT:site05R -0.65182 6.22081 -0.105
## time_firstPFT:site06R -3.26128 4.79874 -0.680
## time_firstPFT:site07R -3.59174 1.42345 -2.523
## time_firstPFT:site09R -6.05643 4.23977 -1.428
## time_firstPFT:site101 -0.36805 1.14511 -0.321
## time_firstPFT:site102 -2.34830 2.09081 -1.123
## time_firstPFT:site103 2.39705 1.11197 2.156
## time_firstPFT:site104 6.94796 3.51557 1.976
## time_firstPFT:site105 0.05957 1.16102 0.051
## time_firstPFT:site106 2.29373 1.58915 1.443
## time_firstPFT:site107 8.02568 6.71422 1.195
## time_firstPFT:site108 6.90057 3.06096 2.254
## time_firstPFT:site11R 2.88475 2.81300 1.026
## time_firstPFT:site12R -0.04441 4.08148 -0.011
## time_firstPFT:site13R -1.44233 4.04115 -0.357
## time_firstPFT:site14R 3.81008 18.97517 0.201
## time_firstPFT:site15R -2.94419 11.37758 -0.259
## time_firstPFT:site16R 2.72559 2.64780 1.029
## time_firstPFT:site18R 6.02783 10.82143 0.557
## time_firstPFT:site19R -2.55623 3.76582 -0.679
## time_firstPFT:site20R 0.50500 3.19121 0.158
## time_firstPFT:site21R 4.29562 4.48780 0.957
## time_firstPFT:site22R -3.01215 2.72240 -1.106
## time_firstPFT:site23R 0.45337 5.21570 0.087
## time_firstPFT:site24R 0.15590 2.30651 0.068
## time_firstPFT:site25R -6.11303 2.72883 -2.240
## time_firstPFT:site28R -11.09356 10.98383 -1.010
## time_firstPFT:site29R -0.03237 4.75101 -0.007
## time_firstPFT:site31R 1.04397 1.96651 0.531
## time_firstPFT:site32R -7.04005 5.35945 -1.314
## time_firstPFT:site33R 1.97469 4.16645 0.474
## time_firstPFT:site34R -0.15989 2.36723 -0.068
## time_firstPFT:site35R 12.01559 4.13217 2.908
## time_firstPFT:site36R 3.32029 2.81657 1.179
## time_firstPFT:site37R -2.07395 2.74038 -0.757
## time_firstPFT:site38R -2.79081 1.85189 -1.507
## time_firstPFT:site39R -46.34525 8.55723 -5.416
## time_firstPFT:site40R -0.12488 4.44151 -0.028
## time_firstPFT:site41R 1.41342 5.52979 0.256
## time_firstPFT:site42R 1.66418 5.41037 0.308##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.738report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## Soil_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 56.87 (95% CI [50.47,
## 63.26], t(2038) = 17.44, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.06, 95% CI [-7.61, -2.52], t(2038) = -3.90, p < .001; Std. beta = -0.40, 95%
## CI [-0.49, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 5.05, 95% CI [-6.54, 16.65], t(2038) = 0.85, p = 0.393; Std. beta =
## 0.11, 95% CI [-0.08, 0.31])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-40.09, 25.81], t(2038) = -0.43, p = 0.671; Std. beta = -1.67,
## 95% CI [-4.36, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-12.07, 35.90], t(2038) = 0.97, p = 0.330; Std. beta = 0.78,
## 95% CI [-0.65, 2.20])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-19.49, 26.53], t(2038) = 0.30, p = 0.764; Std. beta = -0.20,
## 95% CI [-1.68, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.80, 95% CI [-29.82, 8.23], t(2038) = -1.11, p = 0.266; Std. beta = -0.69,
## 95% CI [-2.03, 0.65])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.31, 95% CI [-4.17, 42.79], t(2038) = 1.61, p = 0.107; Std. beta = 0.86,
## 95% CI [-0.62, 2.34])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.58, 95% CI [4.16, 23.00], t(2038) = 2.83, p = 0.005; Std. beta = 0.49, 95%
## CI [-0.07, 1.06])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.00, 95% CI [-0.31, 46.31], t(2038) = 1.93, p = 0.053; Std. beta = 0.84,
## 95% CI [-0.61, 2.29])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-2.45, 10.76], t(2038) = 1.23, p = 0.217; Std. beta = 0.21, 95%
## CI [-0.19, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-0.65, 24.32], t(2038) = 1.86, p = 0.063; Std. beta = 0.50,
## 95% CI [-0.25, 1.25])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-5.59, 6.59], t(2038) = 0.16, p = 0.871; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-16.85, 9.53], t(2038) = -0.54, p = 0.586; Std. beta = 0.37,
## 95% CI [-0.52, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-0.90, 12.29], t(2038) = 1.69, p = 0.090; Std. beta = 0.34, 95%
## CI [-0.06, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.64, 4.78], t(2038) = -0.82, p = 0.413; Std. beta =
## -8.28e-03, 95% CI [-0.50, 0.49])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-27.22, 19.63], t(2038) = -0.32, p = 0.751; Std. beta = 0.45,
## 95% CI [-1.10, 2.00])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.18, 95% CI [-17.64, 19.99], t(2038) = 0.12, p = 0.902; Std. beta = 0.65,
## 95% CI [-0.47, 1.77])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.98, 95% CI [-25.18, 45.13], t(2038) = 0.56, p = 0.578; Std. beta = 0.58,
## 95% CI [-1.48, 2.65])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.30, 95% CI [2.83, 35.77], t(2038) = 2.30, p = 0.022; Std. beta = 1.37, 95%
## CI [0.37, 2.38])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-11.17, 34.99], t(2038) = 1.01, p = 0.312; Std. beta = 0.69,
## 95% CI [-0.74, 2.13])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.89, 95% CI [-0.54, 34.32], t(2038) = 1.90, p = 0.058; Std. beta = 0.87,
## 95% CI [-0.18, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-20.95, 38.24], t(2038) = 0.57, p = 0.567; Std. beta = 0.83,
## 95% CI [-1.64, 3.30])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.85, 95% CI [-60.83, 5.14], t(2038) = -1.66, p = 0.098; Std. beta = -1.88,
## 95% CI [-4.19, 0.43])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.35, 95% CI [-29.08, 0.38], t(2038) = -1.91, p = 0.056; Std. beta = -0.61,
## 95% CI [-1.53, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-27.61, 38.41], t(2038) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.62, 2.25])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-24.82, 22.60], t(2038) = -0.09, p = 0.927; Std. beta = 0.44,
## 95% CI [-1.61, 2.49])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-12.01, 22.67], t(2038) = 0.60, p = 0.547; Std. beta = 0.10,
## 95% CI [-1.00, 1.20])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.56, 95% CI [-11.31, 16.43], t(2038) = 0.36, p = 0.718; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.53, 95% CI [-28.60, 35.66], t(2038) = 0.22, p = 0.829; Std. beta = 0.57,
## 95% CI [-1.33, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-8.04, 13.41], t(2038) = 0.49, p = 0.623; Std. beta = -0.10,
## 95% CI [-0.79, 0.60])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.59, 95% CI [-30.15, 2.98], t(2038) = -1.61, p = 0.108; Std. beta = -0.76,
## 95% CI [-1.95, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.52, 95% CI [-5.99, 19.04], t(2038) = 1.02, p = 0.307; Std. beta = 0.40, 95%
## CI [-0.36, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.30, 15.99], t(2038) = 0.34, p = 0.736; Std. beta = -0.38,
## 95% CI [-1.21, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.96, 95% CI [-18.19, 20.11], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-34.98, 30.69], t(2038) = -0.13, p = 0.898; Std. beta = -0.13,
## 95% CI [-2.04, 1.79])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-9.63, 19.69], t(2038) = 0.67, p = 0.501; Std. beta = 0.38, 95%
## CI [-0.48, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.06, 95% CI [-20.86, 28.99], t(2038) = 0.32, p = 0.749; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.38, 95% CI [-37.94, -0.82], t(2038) = -2.05, p = 0.041; Std. beta = -0.97,
## 95% CI [-2.17, 0.23])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-9.07, 16.32], t(2038) = 0.56, p = 0.575; Std. beta = 0.20, 95%
## CI [-0.58, 0.98])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-11.94, 26.57], t(2038) = 0.75, p = 0.456; Std. beta = 1.44,
## 95% CI [0.25, 2.63])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.39, 95% CI [-27.12, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.45,
## 95% CI [-1.37, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.85, 95% CI [-2.53, 30.23], t(2038) = 1.66, p = 0.097; Std. beta = 0.64,
## 95% CI [-0.35, 1.62])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.21, 95% CI [2.09, 24.33], t(2038) = 2.33, p = 0.020; Std. beta = 0.54, 95%
## CI [-0.13, 1.21])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.76, 95% CI [-14.94, 50.46], t(2038) = 1.07, p = 0.287; Std. beta = -2.86,
## 95% CI [-4.97, -0.74])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.21, 95% CI [3.92, 50.49], t(2038) = 2.29, p = 0.022; Std. beta = 1.58, 95%
## CI [0.12, 3.05])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-19.20, 18.78], t(2038) = -0.02, p = 0.983; Std. beta = 0.11,
## 95% CI [-1.18, 1.39])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-9.73, 11.03], t(2038) = 0.12, p = 0.902; Std. beta = 0.18, 95%
## CI [-0.75, 1.10])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.59, 95% CI [-2.91, 6.09], t(2038) = 0.69, p = 0.488;
## Std. beta = 0.04, 95% CI [-0.07, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.83, 95% CI [-43.76, 14.10], t(2038) = -1.01, p = 0.315;
## Std. beta = -1.38, 95% CI [-4.08, 1.32])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.07, 10.94], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.09, 95% CI [-0.85, 1.02])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.82, 95% CI [-15.64, 6.00], t(2038) = -0.87, p = 0.382; Std.
## beta = -0.45, 95% CI [-1.46, 0.56])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-12.85, 11.55], t(2038) = -0.10, p = 0.917;
## Std. beta = -0.06, 95% CI [-1.20, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.67, 6.15], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.30, 95% CI [-1.18, 0.57])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.59, 95% CI [-6.38, -0.80], t(2038) = -2.52, p = 0.012; Std.
## beta = -0.33, 95% CI [-0.60, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.06, 95% CI [-14.37, 2.26], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.56, 95% CI [-1.34, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.61, 1.88], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-6.45, 1.75], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.22, 95% CI [-0.60, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.22, 4.58], t(2038) = 2.16, p = 0.031; Std.
## beta = 0.22, 95% CI [0.02, 0.43])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 6.95, 95% CI [0.05, 13.84], t(2038) = 1.98, p = 0.048; Std.
## beta = 0.65, 95% CI [4.98e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.22, 2.34], t(2038) = 0.05, p = 0.959; Std.
## beta = 5.55e-03, 95% CI [-0.21, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-0.82, 5.41], t(2038) = 1.44, p = 0.149; Std.
## beta = 0.21, 95% CI [-0.08, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.03, 95% CI [-5.14, 21.19], t(2038) = 1.20, p = 0.232; Std.
## beta = 0.75, 95% CI [-0.48, 1.98])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.90, 95% CI [0.90, 12.90], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.64, 95% CI [0.08, 1.20])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-2.63, 8.40], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.27, 95% CI [-0.25, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-8.05, 7.96], t(2038) = -0.01, p = 0.991; Std.
## beta = -4.14e-03, 95% CI [-0.75, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.37, 6.48], t(2038) = -0.36, p = 0.721; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-33.40, 41.02], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.36, 95% CI [-3.11, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-25.26, 19.37], t(2038) = -0.26, p = 0.796;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.73, 95% CI [-2.47, 7.92], t(2038) = 1.03, p = 0.303; Std.
## beta = 0.25, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-15.19, 27.25], t(2038) = 0.56, p = 0.578; Std.
## beta = 0.56, 95% CI [-1.42, 2.54])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-9.94, 4.83], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.24, 95% CI [-0.93, 0.45])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-5.75, 6.76], t(2038) = 0.16, p = 0.874; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.30, 95% CI [-4.51, 13.10], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.40, 95% CI [-0.42, 1.22])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-8.35, 2.33], t(2038) = -1.11, p = 0.269; Std.
## beta = -0.28, 95% CI [-0.78, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-9.78, 10.68], t(2038) = 0.09, p = 0.931; Std.
## beta = 0.04, 95% CI [-0.91, 1.00])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-4.37, 4.68], t(2038) = 0.07, p = 0.946; Std.
## beta = 0.01, 95% CI [-0.41, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.11, 95% CI [-11.46, -0.76], t(2038) = -2.24, p = 0.025;
## Std. beta = -0.57, 95% CI [-1.07, -0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.09, 95% CI [-32.63, 10.45], t(2038) = -1.01, p = 0.313;
## Std. beta = -1.03, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-9.35, 9.28], t(2038) = -6.81e-03, p = 0.995;
## Std. beta = -3.02e-03, 95% CI [-0.87, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-2.81, 4.90], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.10, 95% CI [-0.26, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -7.04, 95% CI [-17.55, 3.47], t(2038) = -1.31, p = 0.189; Std.
## beta = -0.66, 95% CI [-1.64, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-6.20, 10.15], t(2038) = 0.47, p = 0.636; Std.
## beta = 0.18, 95% CI [-0.58, 0.95])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.80, 4.48], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.02, 95% CI [3.91, 20.12], t(2038) = 2.91, p = 0.004; Std.
## beta = 1.12, 95% CI [0.36, 1.88])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-2.20, 8.84], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.31, 95% CI [-0.21, 0.82])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.45, 3.30], t(2038) = -0.76, p = 0.449; Std.
## beta = -0.19, 95% CI [-0.69, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-6.42, 0.84], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.26, 95% CI [-0.60, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.35, 95% CI [-63.13, -29.56], t(2038) = -5.42, p < .001;
## Std. beta = -4.32, 95% CI [-5.89, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-8.84, 8.59], t(2038) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-9.43, 12.26], t(2038) = 0.26, p = 0.798; Std.
## beta = 0.13, 95% CI [-0.88, 1.14])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.95, 12.27], t(2038) = 0.31, p = 0.758; Std.
## beta = 0.16, 95% CI [-0.83, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## Soil_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to Soil_5yrPreDx = 0, is at 56.87 (95% CI [50.47, 63.26], t(2038)
## = 17.44, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.06, 95% CI [-7.61, -2.52], t(2038) = -3.90, p < .001; Std. beta = -0.40, 95%
## CI [-0.49, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 5.05, 95% CI [-6.54, 16.65], t(2038) = 0.85, p = 0.393; Std. beta =
## 0.11, 95% CI [-0.08, 0.31])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-40.09, 25.81], t(2038) = -0.43, p = 0.671; Std. beta = -1.67,
## 95% CI [-4.36, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-12.07, 35.90], t(2038) = 0.97, p = 0.330; Std. beta = 0.78,
## 95% CI [-0.65, 2.20])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-19.49, 26.53], t(2038) = 0.30, p = 0.764; Std. beta = -0.20,
## 95% CI [-1.68, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.80, 95% CI [-29.82, 8.23], t(2038) = -1.11, p = 0.266; Std. beta = -0.69,
## 95% CI [-2.03, 0.65])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.31, 95% CI [-4.17, 42.79], t(2038) = 1.61, p = 0.107; Std. beta = 0.86,
## 95% CI [-0.62, 2.34])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.58, 95% CI [4.16, 23.00], t(2038) = 2.83, p = 0.005; Std. beta = 0.49, 95%
## CI [-0.07, 1.06])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.00, 95% CI [-0.31, 46.31], t(2038) = 1.93, p = 0.053; Std. beta = 0.84,
## 95% CI [-0.61, 2.29])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-2.45, 10.76], t(2038) = 1.23, p = 0.217; Std. beta = 0.21, 95%
## CI [-0.19, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-0.65, 24.32], t(2038) = 1.86, p = 0.063; Std. beta = 0.50,
## 95% CI [-0.25, 1.25])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-5.59, 6.59], t(2038) = 0.16, p = 0.871; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-16.85, 9.53], t(2038) = -0.54, p = 0.586; Std. beta = 0.37,
## 95% CI [-0.52, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-0.90, 12.29], t(2038) = 1.69, p = 0.090; Std. beta = 0.34, 95%
## CI [-0.06, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.64, 4.78], t(2038) = -0.82, p = 0.413; Std. beta =
## -8.28e-03, 95% CI [-0.50, 0.49])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-27.22, 19.63], t(2038) = -0.32, p = 0.751; Std. beta = 0.45,
## 95% CI [-1.10, 2.00])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.18, 95% CI [-17.64, 19.99], t(2038) = 0.12, p = 0.902; Std. beta = 0.65,
## 95% CI [-0.47, 1.77])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.98, 95% CI [-25.18, 45.13], t(2038) = 0.56, p = 0.578; Std. beta = 0.58,
## 95% CI [-1.48, 2.65])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.30, 95% CI [2.83, 35.77], t(2038) = 2.30, p = 0.022; Std. beta = 1.37, 95%
## CI [0.37, 2.38])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-11.17, 34.99], t(2038) = 1.01, p = 0.312; Std. beta = 0.69,
## 95% CI [-0.74, 2.13])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.89, 95% CI [-0.54, 34.32], t(2038) = 1.90, p = 0.058; Std. beta = 0.87,
## 95% CI [-0.18, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-20.95, 38.24], t(2038) = 0.57, p = 0.567; Std. beta = 0.83,
## 95% CI [-1.64, 3.30])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.85, 95% CI [-60.83, 5.14], t(2038) = -1.66, p = 0.098; Std. beta = -1.88,
## 95% CI [-4.19, 0.43])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.35, 95% CI [-29.08, 0.38], t(2038) = -1.91, p = 0.056; Std. beta = -0.61,
## 95% CI [-1.53, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-27.61, 38.41], t(2038) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.62, 2.25])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-24.82, 22.60], t(2038) = -0.09, p = 0.927; Std. beta = 0.44,
## 95% CI [-1.61, 2.49])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-12.01, 22.67], t(2038) = 0.60, p = 0.547; Std. beta = 0.10,
## 95% CI [-1.00, 1.20])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.56, 95% CI [-11.31, 16.43], t(2038) = 0.36, p = 0.718; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.53, 95% CI [-28.60, 35.66], t(2038) = 0.22, p = 0.829; Std. beta = 0.57,
## 95% CI [-1.33, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-8.04, 13.41], t(2038) = 0.49, p = 0.623; Std. beta = -0.10,
## 95% CI [-0.79, 0.60])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.59, 95% CI [-30.15, 2.98], t(2038) = -1.61, p = 0.108; Std. beta = -0.76,
## 95% CI [-1.95, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.52, 95% CI [-5.99, 19.04], t(2038) = 1.02, p = 0.307; Std. beta = 0.40, 95%
## CI [-0.36, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.30, 15.99], t(2038) = 0.34, p = 0.736; Std. beta = -0.38,
## 95% CI [-1.21, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.96, 95% CI [-18.19, 20.11], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-34.98, 30.69], t(2038) = -0.13, p = 0.898; Std. beta = -0.13,
## 95% CI [-2.04, 1.79])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-9.63, 19.69], t(2038) = 0.67, p = 0.501; Std. beta = 0.38, 95%
## CI [-0.48, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.06, 95% CI [-20.86, 28.99], t(2038) = 0.32, p = 0.749; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.38, 95% CI [-37.94, -0.82], t(2038) = -2.05, p = 0.041; Std. beta = -0.97,
## 95% CI [-2.17, 0.23])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-9.07, 16.32], t(2038) = 0.56, p = 0.575; Std. beta = 0.20, 95%
## CI [-0.58, 0.98])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-11.94, 26.57], t(2038) = 0.75, p = 0.456; Std. beta = 1.44,
## 95% CI [0.25, 2.63])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.39, 95% CI [-27.12, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.45,
## 95% CI [-1.37, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.85, 95% CI [-2.53, 30.23], t(2038) = 1.66, p = 0.097; Std. beta = 0.64,
## 95% CI [-0.35, 1.62])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.21, 95% CI [2.09, 24.33], t(2038) = 2.33, p = 0.020; Std. beta = 0.54, 95%
## CI [-0.13, 1.21])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.76, 95% CI [-14.94, 50.46], t(2038) = 1.07, p = 0.287; Std. beta = -2.86,
## 95% CI [-4.97, -0.74])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.21, 95% CI [3.92, 50.49], t(2038) = 2.29, p = 0.022; Std. beta = 1.58, 95%
## CI [0.12, 3.05])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-19.20, 18.78], t(2038) = -0.02, p = 0.983; Std. beta = 0.11,
## 95% CI [-1.18, 1.39])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-9.73, 11.03], t(2038) = 0.12, p = 0.902; Std. beta = 0.18, 95%
## CI [-0.75, 1.10])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.59, 95% CI [-2.91, 6.09], t(2038) = 0.69, p = 0.488;
## Std. beta = 0.04, 95% CI [-0.07, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.83, 95% CI [-43.76, 14.10], t(2038) = -1.01, p = 0.315;
## Std. beta = -1.38, 95% CI [-4.08, 1.32])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.07, 10.94], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.09, 95% CI [-0.85, 1.02])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.82, 95% CI [-15.64, 6.00], t(2038) = -0.87, p = 0.382; Std.
## beta = -0.45, 95% CI [-1.46, 0.56])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-12.85, 11.55], t(2038) = -0.10, p = 0.917;
## Std. beta = -0.06, 95% CI [-1.20, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.67, 6.15], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.30, 95% CI [-1.18, 0.57])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.59, 95% CI [-6.38, -0.80], t(2038) = -2.52, p = 0.012; Std.
## beta = -0.33, 95% CI [-0.60, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.06, 95% CI [-14.37, 2.26], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.56, 95% CI [-1.34, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.61, 1.88], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-6.45, 1.75], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.22, 95% CI [-0.60, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.22, 4.58], t(2038) = 2.16, p = 0.031; Std.
## beta = 0.22, 95% CI [0.02, 0.43])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 6.95, 95% CI [0.05, 13.84], t(2038) = 1.98, p = 0.048; Std.
## beta = 0.65, 95% CI [4.98e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.22, 2.34], t(2038) = 0.05, p = 0.959; Std.
## beta = 5.55e-03, 95% CI [-0.21, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-0.82, 5.41], t(2038) = 1.44, p = 0.149; Std.
## beta = 0.21, 95% CI [-0.08, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.03, 95% CI [-5.14, 21.19], t(2038) = 1.20, p = 0.232; Std.
## beta = 0.75, 95% CI [-0.48, 1.98])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.90, 95% CI [0.90, 12.90], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.64, 95% CI [0.08, 1.20])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-2.63, 8.40], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.27, 95% CI [-0.25, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-8.05, 7.96], t(2038) = -0.01, p = 0.991; Std.
## beta = -4.14e-03, 95% CI [-0.75, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.37, 6.48], t(2038) = -0.36, p = 0.721; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-33.40, 41.02], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.36, 95% CI [-3.11, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-25.26, 19.37], t(2038) = -0.26, p = 0.796;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.73, 95% CI [-2.47, 7.92], t(2038) = 1.03, p = 0.303; Std.
## beta = 0.25, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-15.19, 27.25], t(2038) = 0.56, p = 0.578; Std.
## beta = 0.56, 95% CI [-1.42, 2.54])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-9.94, 4.83], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.24, 95% CI [-0.93, 0.45])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-5.75, 6.76], t(2038) = 0.16, p = 0.874; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.30, 95% CI [-4.51, 13.10], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.40, 95% CI [-0.42, 1.22])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-8.35, 2.33], t(2038) = -1.11, p = 0.269; Std.
## beta = -0.28, 95% CI [-0.78, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-9.78, 10.68], t(2038) = 0.09, p = 0.931; Std.
## beta = 0.04, 95% CI [-0.91, 1.00])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-4.37, 4.68], t(2038) = 0.07, p = 0.946; Std.
## beta = 0.01, 95% CI [-0.41, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.11, 95% CI [-11.46, -0.76], t(2038) = -2.24, p = 0.025;
## Std. beta = -0.57, 95% CI [-1.07, -0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.09, 95% CI [-32.63, 10.45], t(2038) = -1.01, p = 0.313;
## Std. beta = -1.03, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-9.35, 9.28], t(2038) = -6.81e-03, p = 0.995;
## Std. beta = -3.02e-03, 95% CI [-0.87, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-2.81, 4.90], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.10, 95% CI [-0.26, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -7.04, 95% CI [-17.55, 3.47], t(2038) = -1.31, p = 0.189; Std.
## beta = -0.66, 95% CI [-1.64, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-6.20, 10.15], t(2038) = 0.47, p = 0.636; Std.
## beta = 0.18, 95% CI [-0.58, 0.95])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.80, 4.48], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.02, 95% CI [3.91, 20.12], t(2038) = 2.91, p = 0.004; Std.
## beta = 1.12, 95% CI [0.36, 1.88])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-2.20, 8.84], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.31, 95% CI [-0.21, 0.82])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.45, 3.30], t(2038) = -0.76, p = 0.449; Std.
## beta = -0.19, 95% CI [-0.69, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-6.42, 0.84], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.26, 95% CI [-0.60, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.35, 95% CI [-63.13, -29.56], t(2038) = -5.42, p < .001;
## Std. beta = -4.32, 95% CI [-5.89, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-8.84, 8.59], t(2038) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-9.43, 12.26], t(2038) = 0.26, p = 0.798; Std.
## beta = 0.13, 95% CI [-0.88, 1.14])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.95, 12.27], t(2038) = 0.31, p = 0.758; Std.
## beta = 0.16, 95% CI [-0.83, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 56.87 (95% CI [50.47, 63.26], t(2038) = 17.44, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.06, 95% CI [-7.61, -2.52], t(2038) = -3.90, p < .001; Std. beta = -0.40, 95%
## CI [-0.49, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 5.05, 95% CI [-6.54, 16.65], t(2038) = 0.85, p = 0.393; Std. beta =
## 0.11, 95% CI [-0.08, 0.31])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-40.09, 25.81], t(2038) = -0.43, p = 0.671; Std. beta = -1.67,
## 95% CI [-4.36, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-12.07, 35.90], t(2038) = 0.97, p = 0.330; Std. beta = 0.78,
## 95% CI [-0.65, 2.20])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-19.49, 26.53], t(2038) = 0.30, p = 0.764; Std. beta = -0.20,
## 95% CI [-1.68, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.80, 95% CI [-29.82, 8.23], t(2038) = -1.11, p = 0.266; Std. beta = -0.69,
## 95% CI [-2.03, 0.65])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.31, 95% CI [-4.17, 42.79], t(2038) = 1.61, p = 0.107; Std. beta = 0.86,
## 95% CI [-0.62, 2.34])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.58, 95% CI [4.16, 23.00], t(2038) = 2.83, p = 0.005; Std. beta = 0.49, 95%
## CI [-0.07, 1.06])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.00, 95% CI [-0.31, 46.31], t(2038) = 1.93, p = 0.053; Std. beta = 0.84,
## 95% CI [-0.61, 2.29])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-2.45, 10.76], t(2038) = 1.23, p = 0.217; Std. beta = 0.21, 95%
## CI [-0.19, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-0.65, 24.32], t(2038) = 1.86, p = 0.063; Std. beta = 0.50,
## 95% CI [-0.25, 1.25])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-5.59, 6.59], t(2038) = 0.16, p = 0.871; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-16.85, 9.53], t(2038) = -0.54, p = 0.586; Std. beta = 0.37,
## 95% CI [-0.52, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-0.90, 12.29], t(2038) = 1.69, p = 0.090; Std. beta = 0.34, 95%
## CI [-0.06, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.64, 4.78], t(2038) = -0.82, p = 0.413; Std. beta =
## -8.28e-03, 95% CI [-0.50, 0.49])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-27.22, 19.63], t(2038) = -0.32, p = 0.751; Std. beta = 0.45,
## 95% CI [-1.10, 2.00])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.18, 95% CI [-17.64, 19.99], t(2038) = 0.12, p = 0.902; Std. beta = 0.65,
## 95% CI [-0.47, 1.77])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.98, 95% CI [-25.18, 45.13], t(2038) = 0.56, p = 0.578; Std. beta = 0.58,
## 95% CI [-1.48, 2.65])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.30, 95% CI [2.83, 35.77], t(2038) = 2.30, p = 0.022; Std. beta = 1.37, 95%
## CI [0.37, 2.38])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-11.17, 34.99], t(2038) = 1.01, p = 0.312; Std. beta = 0.69,
## 95% CI [-0.74, 2.13])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.89, 95% CI [-0.54, 34.32], t(2038) = 1.90, p = 0.058; Std. beta = 0.87,
## 95% CI [-0.18, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-20.95, 38.24], t(2038) = 0.57, p = 0.567; Std. beta = 0.83,
## 95% CI [-1.64, 3.30])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.85, 95% CI [-60.83, 5.14], t(2038) = -1.66, p = 0.098; Std. beta = -1.88,
## 95% CI [-4.19, 0.43])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.35, 95% CI [-29.08, 0.38], t(2038) = -1.91, p = 0.056; Std. beta = -0.61,
## 95% CI [-1.53, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-27.61, 38.41], t(2038) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.62, 2.25])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-24.82, 22.60], t(2038) = -0.09, p = 0.927; Std. beta = 0.44,
## 95% CI [-1.61, 2.49])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-12.01, 22.67], t(2038) = 0.60, p = 0.547; Std. beta = 0.10,
## 95% CI [-1.00, 1.20])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.56, 95% CI [-11.31, 16.43], t(2038) = 0.36, p = 0.718; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.53, 95% CI [-28.60, 35.66], t(2038) = 0.22, p = 0.829; Std. beta = 0.57,
## 95% CI [-1.33, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-8.04, 13.41], t(2038) = 0.49, p = 0.623; Std. beta = -0.10,
## 95% CI [-0.79, 0.60])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.59, 95% CI [-30.15, 2.98], t(2038) = -1.61, p = 0.108; Std. beta = -0.76,
## 95% CI [-1.95, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.52, 95% CI [-5.99, 19.04], t(2038) = 1.02, p = 0.307; Std. beta = 0.40, 95%
## CI [-0.36, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.30, 15.99], t(2038) = 0.34, p = 0.736; Std. beta = -0.38,
## 95% CI [-1.21, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.96, 95% CI [-18.19, 20.11], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-34.98, 30.69], t(2038) = -0.13, p = 0.898; Std. beta = -0.13,
## 95% CI [-2.04, 1.79])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-9.63, 19.69], t(2038) = 0.67, p = 0.501; Std. beta = 0.38, 95%
## CI [-0.48, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.06, 95% CI [-20.86, 28.99], t(2038) = 0.32, p = 0.749; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.38, 95% CI [-37.94, -0.82], t(2038) = -2.05, p = 0.041; Std. beta = -0.97,
## 95% CI [-2.17, 0.23])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-9.07, 16.32], t(2038) = 0.56, p = 0.575; Std. beta = 0.20, 95%
## CI [-0.58, 0.98])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-11.94, 26.57], t(2038) = 0.75, p = 0.456; Std. beta = 1.44,
## 95% CI [0.25, 2.63])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.39, 95% CI [-27.12, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.45,
## 95% CI [-1.37, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.85, 95% CI [-2.53, 30.23], t(2038) = 1.66, p = 0.097; Std. beta = 0.64,
## 95% CI [-0.35, 1.62])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.21, 95% CI [2.09, 24.33], t(2038) = 2.33, p = 0.020; Std. beta = 0.54, 95%
## CI [-0.13, 1.21])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.76, 95% CI [-14.94, 50.46], t(2038) = 1.07, p = 0.287; Std. beta = -2.86,
## 95% CI [-4.97, -0.74])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.21, 95% CI [3.92, 50.49], t(2038) = 2.29, p = 0.022; Std. beta = 1.58, 95%
## CI [0.12, 3.05])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-19.20, 18.78], t(2038) = -0.02, p = 0.983; Std. beta = 0.11,
## 95% CI [-1.18, 1.39])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-9.73, 11.03], t(2038) = 0.12, p = 0.902; Std. beta = 0.18, 95%
## CI [-0.75, 1.10])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.59, 95% CI [-2.91, 6.09], t(2038) = 0.69, p = 0.488;
## Std. beta = 0.04, 95% CI [-0.07, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.83, 95% CI [-43.76, 14.10], t(2038) = -1.01, p = 0.315;
## Std. beta = -1.38, 95% CI [-4.08, 1.32])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.07, 10.94], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.09, 95% CI [-0.85, 1.02])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.82, 95% CI [-15.64, 6.00], t(2038) = -0.87, p = 0.382; Std.
## beta = -0.45, 95% CI [-1.46, 0.56])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-12.85, 11.55], t(2038) = -0.10, p = 0.917;
## Std. beta = -0.06, 95% CI [-1.20, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.67, 6.15], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.30, 95% CI [-1.18, 0.57])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.59, 95% CI [-6.38, -0.80], t(2038) = -2.52, p = 0.012; Std.
## beta = -0.33, 95% CI [-0.60, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.06, 95% CI [-14.37, 2.26], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.56, 95% CI [-1.34, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.61, 1.88], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-6.45, 1.75], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.22, 95% CI [-0.60, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.22, 4.58], t(2038) = 2.16, p = 0.031; Std.
## beta = 0.22, 95% CI [0.02, 0.43])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 6.95, 95% CI [0.05, 13.84], t(2038) = 1.98, p = 0.048; Std.
## beta = 0.65, 95% CI [4.98e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.22, 2.34], t(2038) = 0.05, p = 0.959; Std.
## beta = 5.55e-03, 95% CI [-0.21, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-0.82, 5.41], t(2038) = 1.44, p = 0.149; Std.
## beta = 0.21, 95% CI [-0.08, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.03, 95% CI [-5.14, 21.19], t(2038) = 1.20, p = 0.232; Std.
## beta = 0.75, 95% CI [-0.48, 1.98])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.90, 95% CI [0.90, 12.90], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.64, 95% CI [0.08, 1.20])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-2.63, 8.40], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.27, 95% CI [-0.25, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-8.05, 7.96], t(2038) = -0.01, p = 0.991; Std.
## beta = -4.14e-03, 95% CI [-0.75, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.37, 6.48], t(2038) = -0.36, p = 0.721; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-33.40, 41.02], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.36, 95% CI [-3.11, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-25.26, 19.37], t(2038) = -0.26, p = 0.796;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.73, 95% CI [-2.47, 7.92], t(2038) = 1.03, p = 0.303; Std.
## beta = 0.25, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-15.19, 27.25], t(2038) = 0.56, p = 0.578; Std.
## beta = 0.56, 95% CI [-1.42, 2.54])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-9.94, 4.83], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.24, 95% CI [-0.93, 0.45])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-5.75, 6.76], t(2038) = 0.16, p = 0.874; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.30, 95% CI [-4.51, 13.10], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.40, 95% CI [-0.42, 1.22])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-8.35, 2.33], t(2038) = -1.11, p = 0.269; Std.
## beta = -0.28, 95% CI [-0.78, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-9.78, 10.68], t(2038) = 0.09, p = 0.931; Std.
## beta = 0.04, 95% CI [-0.91, 1.00])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-4.37, 4.68], t(2038) = 0.07, p = 0.946; Std.
## beta = 0.01, 95% CI [-0.41, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.11, 95% CI [-11.46, -0.76], t(2038) = -2.24, p = 0.025;
## Std. beta = -0.57, 95% CI [-1.07, -0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.09, 95% CI [-32.63, 10.45], t(2038) = -1.01, p = 0.313;
## Std. beta = -1.03, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-9.35, 9.28], t(2038) = -6.81e-03, p = 0.995;
## Std. beta = -3.02e-03, 95% CI [-0.87, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-2.81, 4.90], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.10, 95% CI [-0.26, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -7.04, 95% CI [-17.55, 3.47], t(2038) = -1.31, p = 0.189; Std.
## beta = -0.66, 95% CI [-1.64, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-6.20, 10.15], t(2038) = 0.47, p = 0.636; Std.
## beta = 0.18, 95% CI [-0.58, 0.95])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.80, 4.48], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.02, 95% CI [3.91, 20.12], t(2038) = 2.91, p = 0.004; Std.
## beta = 1.12, 95% CI [0.36, 1.88])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-2.20, 8.84], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.31, 95% CI [-0.21, 0.82])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.45, 3.30], t(2038) = -0.76, p = 0.449; Std.
## beta = -0.19, 95% CI [-0.69, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-6.42, 0.84], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.26, 95% CI [-0.60, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.35, 95% CI [-63.13, -29.56], t(2038) = -5.42, p < .001;
## Std. beta = -4.32, 95% CI [-5.89, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-8.84, 8.59], t(2038) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-9.43, 12.26], t(2038) = 0.26, p = 0.798; Std.
## beta = 0.13, 95% CI [-0.88, 1.14])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.95, 12.27], t(2038) = 0.31, p = 0.758; Std.
## beta = 0.16, 95% CI [-0.83, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to cohort = CARE-PF, is at 56.87 (95% CI [50.47, 63.26], t(2038)
## = 17.44, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.06, 95% CI [-7.61, -2.52], t(2038) = -3.90, p < .001; Std. beta = -0.40, 95%
## CI [-0.49, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 5.05, 95% CI [-6.54, 16.65], t(2038) = 0.85, p = 0.393; Std. beta =
## 0.11, 95% CI [-0.08, 0.31])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.14, 95% CI [-40.09, 25.81], t(2038) = -0.43, p = 0.671; Std. beta = -1.67,
## 95% CI [-4.36, 1.03])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-12.07, 35.90], t(2038) = 0.97, p = 0.330; Std. beta = 0.78,
## 95% CI [-0.65, 2.20])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-19.49, 26.53], t(2038) = 0.30, p = 0.764; Std. beta = -0.20,
## 95% CI [-1.68, 1.29])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.80, 95% CI [-29.82, 8.23], t(2038) = -1.11, p = 0.266; Std. beta = -0.69,
## 95% CI [-2.03, 0.65])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.31, 95% CI [-4.17, 42.79], t(2038) = 1.61, p = 0.107; Std. beta = 0.86,
## 95% CI [-0.62, 2.34])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.58, 95% CI [4.16, 23.00], t(2038) = 2.83, p = 0.005; Std. beta = 0.49, 95%
## CI [-0.07, 1.06])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.00, 95% CI [-0.31, 46.31], t(2038) = 1.93, p = 0.053; Std. beta = 0.84,
## 95% CI [-0.61, 2.29])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-2.45, 10.76], t(2038) = 1.23, p = 0.217; Std. beta = 0.21, 95%
## CI [-0.19, 0.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.84, 95% CI [-0.65, 24.32], t(2038) = 1.86, p = 0.063; Std. beta = 0.50,
## 95% CI [-0.25, 1.25])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-5.59, 6.59], t(2038) = 0.16, p = 0.871; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-16.85, 9.53], t(2038) = -0.54, p = 0.586; Std. beta = 0.37,
## 95% CI [-0.52, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-0.90, 12.29], t(2038) = 1.69, p = 0.090; Std. beta = 0.34, 95%
## CI [-0.06, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.43, 95% CI [-11.64, 4.78], t(2038) = -0.82, p = 0.413; Std. beta =
## -8.28e-03, 95% CI [-0.50, 0.49])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-27.22, 19.63], t(2038) = -0.32, p = 0.751; Std. beta = 0.45,
## 95% CI [-1.10, 2.00])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.18, 95% CI [-17.64, 19.99], t(2038) = 0.12, p = 0.902; Std. beta = 0.65,
## 95% CI [-0.47, 1.77])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.98, 95% CI [-25.18, 45.13], t(2038) = 0.56, p = 0.578; Std. beta = 0.58,
## 95% CI [-1.48, 2.65])
## - The effect of site [11R] is statistically significant and positive (beta =
## 19.30, 95% CI [2.83, 35.77], t(2038) = 2.30, p = 0.022; Std. beta = 1.37, 95%
## CI [0.37, 2.38])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.91, 95% CI [-11.17, 34.99], t(2038) = 1.01, p = 0.312; Std. beta = 0.69,
## 95% CI [-0.74, 2.13])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.89, 95% CI [-0.54, 34.32], t(2038) = 1.90, p = 0.058; Std. beta = 0.87,
## 95% CI [-0.18, 1.92])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-20.95, 38.24], t(2038) = 0.57, p = 0.567; Std. beta = 0.83,
## 95% CI [-1.64, 3.30])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.85, 95% CI [-60.83, 5.14], t(2038) = -1.66, p = 0.098; Std. beta = -1.88,
## 95% CI [-4.19, 0.43])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.35, 95% CI [-29.08, 0.38], t(2038) = -1.91, p = 0.056; Std. beta = -0.61,
## 95% CI [-1.53, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-27.61, 38.41], t(2038) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.62, 2.25])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-24.82, 22.60], t(2038) = -0.09, p = 0.927; Std. beta = 0.44,
## 95% CI [-1.61, 2.49])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.33, 95% CI [-12.01, 22.67], t(2038) = 0.60, p = 0.547; Std. beta = 0.10,
## 95% CI [-1.00, 1.20])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.56, 95% CI [-11.31, 16.43], t(2038) = 0.36, p = 0.718; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.53, 95% CI [-28.60, 35.66], t(2038) = 0.22, p = 0.829; Std. beta = 0.57,
## 95% CI [-1.33, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-8.04, 13.41], t(2038) = 0.49, p = 0.623; Std. beta = -0.10,
## 95% CI [-0.79, 0.60])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.59, 95% CI [-30.15, 2.98], t(2038) = -1.61, p = 0.108; Std. beta = -0.76,
## 95% CI [-1.95, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.52, 95% CI [-5.99, 19.04], t(2038) = 1.02, p = 0.307; Std. beta = 0.40, 95%
## CI [-0.36, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.30, 15.99], t(2038) = 0.34, p = 0.736; Std. beta = -0.38,
## 95% CI [-1.21, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.96, 95% CI [-18.19, 20.11], t(2038) = 0.10, p = 0.922; Std. beta = -0.88,
## 95% CI [-2.86, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.14, 95% CI [-34.98, 30.69], t(2038) = -0.13, p = 0.898; Std. beta = -0.13,
## 95% CI [-2.04, 1.79])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-9.63, 19.69], t(2038) = 0.67, p = 0.501; Std. beta = 0.38, 95%
## CI [-0.48, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.06, 95% CI [-20.86, 28.99], t(2038) = 0.32, p = 0.749; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.38, 95% CI [-37.94, -0.82], t(2038) = -2.05, p = 0.041; Std. beta = -0.97,
## 95% CI [-2.17, 0.23])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-9.07, 16.32], t(2038) = 0.56, p = 0.575; Std. beta = 0.20, 95%
## CI [-0.58, 0.98])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.32, 95% CI [-11.94, 26.57], t(2038) = 0.75, p = 0.456; Std. beta = 1.44,
## 95% CI [0.25, 2.63])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.39, 95% CI [-27.12, 2.33], t(2038) = -1.65, p = 0.099; Std. beta = -0.45,
## 95% CI [-1.37, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.85, 95% CI [-2.53, 30.23], t(2038) = 1.66, p = 0.097; Std. beta = 0.64,
## 95% CI [-0.35, 1.62])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.21, 95% CI [2.09, 24.33], t(2038) = 2.33, p = 0.020; Std. beta = 0.54, 95%
## CI [-0.13, 1.21])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.76, 95% CI [-14.94, 50.46], t(2038) = 1.07, p = 0.287; Std. beta = -2.86,
## 95% CI [-4.97, -0.74])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.21, 95% CI [3.92, 50.49], t(2038) = 2.29, p = 0.022; Std. beta = 1.58, 95%
## CI [0.12, 3.05])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.21, 95% CI [-19.20, 18.78], t(2038) = -0.02, p = 0.983; Std. beta = 0.11,
## 95% CI [-1.18, 1.39])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-9.73, 11.03], t(2038) = 0.12, p = 0.902; Std. beta = 0.18, 95%
## CI [-0.75, 1.10])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.59, 95% CI [-2.91, 6.09], t(2038) = 0.69, p = 0.488;
## Std. beta = 0.04, 95% CI [-0.07, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.83, 95% CI [-43.76, 14.10], t(2038) = -1.01, p = 0.315;
## Std. beta = -1.38, 95% CI [-4.08, 1.32])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.07, 10.94], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.09, 95% CI [-0.85, 1.02])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.82, 95% CI [-15.64, 6.00], t(2038) = -0.87, p = 0.382; Std.
## beta = -0.45, 95% CI [-1.46, 0.56])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-12.85, 11.55], t(2038) = -0.10, p = 0.917;
## Std. beta = -0.06, 95% CI [-1.20, 1.08])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.67, 6.15], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.30, 95% CI [-1.18, 0.57])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.59, 95% CI [-6.38, -0.80], t(2038) = -2.52, p = 0.012; Std.
## beta = -0.33, 95% CI [-0.60, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.06, 95% CI [-14.37, 2.26], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.56, 95% CI [-1.34, 0.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.61, 1.88], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.03, 95% CI [-0.24, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-6.45, 1.75], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.22, 95% CI [-0.60, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.22, 4.58], t(2038) = 2.16, p = 0.031; Std.
## beta = 0.22, 95% CI [0.02, 0.43])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 6.95, 95% CI [0.05, 13.84], t(2038) = 1.98, p = 0.048; Std.
## beta = 0.65, 95% CI [4.98e-03, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.22, 2.34], t(2038) = 0.05, p = 0.959; Std.
## beta = 5.55e-03, 95% CI [-0.21, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-0.82, 5.41], t(2038) = 1.44, p = 0.149; Std.
## beta = 0.21, 95% CI [-0.08, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.03, 95% CI [-5.14, 21.19], t(2038) = 1.20, p = 0.232; Std.
## beta = 0.75, 95% CI [-0.48, 1.98])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.90, 95% CI [0.90, 12.90], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.64, 95% CI [0.08, 1.20])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-2.63, 8.40], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.27, 95% CI [-0.25, 0.78])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-8.05, 7.96], t(2038) = -0.01, p = 0.991; Std.
## beta = -4.14e-03, 95% CI [-0.75, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-9.37, 6.48], t(2038) = -0.36, p = 0.721; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.81, 95% CI [-33.40, 41.02], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.36, 95% CI [-3.11, 3.82])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-25.26, 19.37], t(2038) = -0.26, p = 0.796;
## Std. beta = -0.27, 95% CI [-2.35, 1.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.73, 95% CI [-2.47, 7.92], t(2038) = 1.03, p = 0.303; Std.
## beta = 0.25, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-15.19, 27.25], t(2038) = 0.56, p = 0.578; Std.
## beta = 0.56, 95% CI [-1.42, 2.54])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-9.94, 4.83], t(2038) = -0.68, p = 0.497; Std.
## beta = -0.24, 95% CI [-0.93, 0.45])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-5.75, 6.76], t(2038) = 0.16, p = 0.874; Std.
## beta = 0.05, 95% CI [-0.54, 0.63])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.30, 95% CI [-4.51, 13.10], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.40, 95% CI [-0.42, 1.22])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-8.35, 2.33], t(2038) = -1.11, p = 0.269; Std.
## beta = -0.28, 95% CI [-0.78, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-9.78, 10.68], t(2038) = 0.09, p = 0.931; Std.
## beta = 0.04, 95% CI [-0.91, 1.00])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.16, 95% CI [-4.37, 4.68], t(2038) = 0.07, p = 0.946; Std.
## beta = 0.01, 95% CI [-0.41, 0.44])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.11, 95% CI [-11.46, -0.76], t(2038) = -2.24, p = 0.025;
## Std. beta = -0.57, 95% CI [-1.07, -0.07])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.09, 95% CI [-32.63, 10.45], t(2038) = -1.01, p = 0.313;
## Std. beta = -1.03, 95% CI [-3.04, 0.97])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-9.35, 9.28], t(2038) = -6.81e-03, p = 0.995;
## Std. beta = -3.02e-03, 95% CI [-0.87, 0.87])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-2.81, 4.90], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.10, 95% CI [-0.26, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -7.04, 95% CI [-17.55, 3.47], t(2038) = -1.31, p = 0.189; Std.
## beta = -0.66, 95% CI [-1.64, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-6.20, 10.15], t(2038) = 0.47, p = 0.636; Std.
## beta = 0.18, 95% CI [-0.58, 0.95])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-4.80, 4.48], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.45, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.02, 95% CI [3.91, 20.12], t(2038) = 2.91, p = 0.004; Std.
## beta = 1.12, 95% CI [0.36, 1.88])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-2.20, 8.84], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.31, 95% CI [-0.21, 0.82])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.45, 3.30], t(2038) = -0.76, p = 0.449; Std.
## beta = -0.19, 95% CI [-0.69, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-6.42, 0.84], t(2038) = -1.51, p = 0.132; Std.
## beta = -0.26, 95% CI [-0.60, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.35, 95% CI [-63.13, -29.56], t(2038) = -5.42, p < .001;
## Std. beta = -4.32, 95% CI [-5.89, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.12, 95% CI [-8.84, 8.59], t(2038) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.82, 0.80])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-9.43, 12.26], t(2038) = 0.26, p = 0.798; Std.
## beta = 0.13, 95% CI [-0.88, 1.14])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-8.95, 12.27], t(2038) = 0.31, p = 0.758; Std.
## beta = 0.16, 95% CI [-0.83, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*Soil_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14178
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2675 -0.4384 -0.0091 0.4484 4.5166
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 230.86 15.194
## time_firstPFT 13.63 3.692 -0.07
## Residual 25.75 5.075
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 28.545029 6.546287 4.360
## time_firstPFT -2.381125 2.502359 -0.952
## Soil_5yrPreDx 7.289639 5.760733 1.265
## disadv 3.915194 2.866535 1.366
## dich_RaceNon-White -7.828997 2.812898 -2.783
## sexF 3.500337 1.748498 2.002
## age_dx 0.382600 0.091127 4.199
## smokeHxFormer 3.806275 1.725443 2.206
## smokeHxAlways 18.788849 8.384649 2.241
## smokeHxUnknown -2.443850 3.915920 -0.624
## site02R -10.520992 16.132854 -0.652
## site03R 9.347066 11.840228 0.789
## site04R 3.278523 11.220683 0.292
## site05R -12.009968 9.322996 -1.288
## site06R 9.236955 16.123910 0.573
## site07R 12.625454 4.635799 2.723
## site09R 21.999201 11.406416 1.929
## site101 5.518283 3.283058 1.681
## site102 13.185260 6.161948 2.140
## site103 0.656671 3.145312 0.209
## site104 -4.509499 6.510911 -0.693
## site105 5.902547 3.264663 1.808
## site106 -5.139781 4.108641 -1.251
## site107 -0.859429 11.463962 -0.075
## site108 6.536536 9.628116 0.679
## site10R 4.933980 17.537685 0.281
## site11R 15.391085 8.057325 1.910
## site12R 7.420837 11.266253 0.659
## site13R 18.436109 8.584422 2.148
## site14R 8.004295 14.710857 0.544
## site15R -34.411401 16.158005 -2.130
## site16R -7.993210 7.304383 -1.094
## site17R 9.303470 16.278362 0.572
## site18R -5.936048 11.632751 -0.510
## site19R 2.202056 8.513208 0.259
## site20R 0.525455 6.808661 0.077
## site21R 1.592054 15.636883 0.102
## site22R -0.709423 5.336651 -0.133
## site23R -17.738265 9.519390 -1.863
## site24R 5.243704 6.118582 0.857
## site25R 1.472641 6.755043 0.218
## site28R 4.527356 9.415155 0.481
## site29R -4.254037 16.059169 -0.265
## site31R 6.558623 7.228776 0.907
## site32R -2.265830 12.243833 -0.185
## site33R -19.561788 9.095008 -2.151
## site34R 1.486273 6.207631 0.239
## site35R 1.218521 9.445350 0.129
## site36R -11.367233 7.218579 -1.575
## site37R 16.926534 8.108177 2.088
## site38R 13.238529 5.442556 2.432
## site39R 22.954164 16.203261 1.417
## site40R 23.547915 11.386125 2.068
## site41R -2.177614 9.353165 -0.233
## site42R 0.235154 5.148234 0.046
## time_firstPFT:Soil_5yrPreDx 1.780546 2.427106 0.734
## time_firstPFT:disadv -0.326485 1.107662 -0.295
## time_firstPFT:dich_RaceNon-White 0.005276 1.130717 0.005
## time_firstPFT:sexF -0.084927 0.668496 -0.127
## time_firstPFT:age_dx -0.053795 0.034929 -1.540
## time_firstPFT:smokeHxFormer 0.447611 0.675739 0.662
## time_firstPFT:smokeHxAlways 1.418447 5.315859 0.267
## time_firstPFT:smokeHxUnknown 1.436784 1.691489 0.849
## time_firstPFT:site02R -14.249637 14.804442 -0.963
## time_firstPFT:site03R 1.951737 5.195621 0.376
## time_firstPFT:site04R -4.414784 5.609985 -0.787
## time_firstPFT:site05R -0.328096 6.268863 -0.052
## time_firstPFT:site07R -3.140864 1.487614 -2.111
## time_firstPFT:site09R -5.918947 4.342975 -1.363
## time_firstPFT:site101 -0.156122 1.189118 -0.131
## time_firstPFT:site102 -2.482963 2.153540 -1.153
## time_firstPFT:site103 2.685439 1.207860 2.223
## time_firstPFT:site104 7.592026 3.631766 2.090
## time_firstPFT:site105 0.152622 1.192090 0.128
## time_firstPFT:site106 2.873576 1.660926 1.730
## time_firstPFT:site107 8.061997 6.759445 1.193
## time_firstPFT:site108 7.104605 3.331191 2.133
## time_firstPFT:site11R 3.644060 2.922805 1.247
## time_firstPFT:site12R 0.374170 4.187809 0.089
## time_firstPFT:site13R -0.993139 4.128961 -0.241
## time_firstPFT:site14R 4.223096 19.015295 0.222
## time_firstPFT:site15R -2.561736 11.433164 -0.224
## time_firstPFT:site16R 2.512175 2.756336 0.911
## time_firstPFT:site18R 6.497889 10.875720 0.597
## time_firstPFT:site19R -1.936704 3.909122 -0.495
## time_firstPFT:site20R 1.109166 3.283519 0.338
## time_firstPFT:site21R 4.441306 4.582570 0.969
## time_firstPFT:site22R -2.181346 2.797631 -0.780
## time_firstPFT:site23R 10.321085 24.816324 0.416
## time_firstPFT:site24R 0.237311 2.349584 0.101
## time_firstPFT:site25R -5.412049 2.825811 -1.915
## time_firstPFT:site28R -9.251091 11.111936 -0.833
## time_firstPFT:site29R 0.467812 4.866158 0.096
## time_firstPFT:site31R 1.151885 2.054185 0.561
## time_firstPFT:site32R -6.701892 5.562866 -1.205
## time_firstPFT:site33R 2.403165 4.311562 0.557
## time_firstPFT:site34R 0.142324 2.444401 0.058
## time_firstPFT:site35R 12.941642 4.230589 3.059
## time_firstPFT:site36R 3.591729 2.887941 1.244
## time_firstPFT:site37R -1.376037 2.891017 -0.476
## time_firstPFT:site38R -2.523635 1.897017 -1.330
## time_firstPFT:site39R -46.581712 8.685174 -5.363
## time_firstPFT:site40R 0.924111 4.581326 0.202
## time_firstPFT:site41R 2.207985 5.589238 0.395
## time_firstPFT:site42R 2.555682 5.431645 0.471##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.916
## Unadjusted ICC: 0.687report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## Soil_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 28.55 (95% CI [15.71, 41.38], t(2008)
## = 4.36, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## Soil_5yrPreDx (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to Soil_5yrPreDx
## = 0, is at 28.55 (95% CI [15.71, 41.38], t(2008) = 4.36, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 28.55 (95% CI [15.71,
## 41.38], t(2008) = 4.36, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to dich_Race = White, is at 28.55 (95% CI
## [15.71, 41.38], t(2008) = 4.36, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 28.55 (95% CI [15.71,
## 41.38], t(2008) = 4.36, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 28.55 (95% CI [15.71,
## 41.38], t(2008) = 4.36, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 28.55 (95% CI
## [15.71, 41.38], t(2008) = 4.36, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 28.55 (95% CI [15.71,
## 41.38], t(2008) = 4.36, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to cohort =
## CARE-PF, is at 28.55 (95% CI [15.71, 41.38], t(2008) = 4.36, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.38, 95% CI [-7.29, 2.53], t(2008) = -0.95, p = 0.341; Std. beta =
## -0.46, 95% CI [-0.60, -0.31])
## - The effect of Soil 5yrPreDx is statistically non-significant and positive
## (beta = 7.29, 95% CI [-4.01, 18.59], t(2008) = 1.27, p = 0.206; Std. beta =
## 0.15, 95% CI [-0.04, 0.35])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.92, 95% CI [-1.71, 9.54], t(2008) = 1.37, p = 0.172; Std. beta = 0.06, 95% CI
## [-0.04, 0.16])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.83, 95% CI [-13.35, -2.31], t(2008) = -2.78, p = 0.005; Std. beta =
## -0.46, 95% CI [-0.81, -0.11])
## - The effect of sex [F] is statistically significant and positive (beta = 3.50,
## 95% CI [0.07, 6.93], t(2008) = 2.00, p = 0.045; Std. beta = 0.20, 95% CI
## [-0.02, 0.41])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2008) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.81, 95% CI [0.42, 7.19], t(2008) = 2.21, p = 0.027; Std. beta = 0.26,
## 95% CI [0.05, 0.47])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.79, 95% CI [2.35, 35.23], t(2008) = 2.24, p = 0.025; Std. beta =
## 1.22, 95% CI [0.05, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.44, 95% CI [-10.12, 5.24], t(2008) = -0.62, p = 0.533; Std. beta =
## -0.02, 95% CI [-0.52, 0.48])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-42.16, 21.12], t(2008) = -0.65, p = 0.514; Std. beta =
## -1.82, 95% CI [-4.48, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-13.87, 32.57], t(2008) = 0.79, p = 0.430; Std. beta = 0.71,
## 95% CI [-0.69, 2.11])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-18.73, 25.28], t(2008) = 0.29, p = 0.770; Std. beta = -0.18,
## 95% CI [-1.63, 1.27])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.01, 95% CI [-30.29, 6.27], t(2008) = -1.29, p = 0.198; Std. beta = -0.73,
## 95% CI [-2.05, 0.59])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.24, 95% CI [-22.38, 40.86], t(2008) = 0.57, p = 0.567; Std. beta = 0.54,
## 95% CI [-1.31, 2.40])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.63, 95% CI [3.53, 21.72], t(2008) = 2.72, p = 0.007; Std. beta = 0.47, 95%
## CI [-0.08, 1.03])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.00, 95% CI [-0.37, 44.37], t(2008) = 1.93, p = 0.054; Std. beta = 0.79,
## 95% CI [-0.63, 2.21])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 5.52, 95% CI [-0.92, 11.96], t(2008) = 1.68, p = 0.093; Std. beta = 0.31, 95%
## CI [-0.09, 0.71])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.19, 95% CI [1.10, 25.27], t(2008) = 2.14, p = 0.032; Std. beta = 0.56, 95%
## CI [-0.17, 1.30])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-5.51, 6.83], t(2008) = 0.21, p = 0.835; Std. beta = 0.27, 95%
## CI [-0.12, 0.65])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -4.51, 95% CI [-17.28, 8.26], t(2008) = -0.69, p = 0.489; Std. beta = 0.38,
## 95% CI [-0.51, 1.27])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.90, 95% CI [-0.50, 12.31], t(2008) = 1.81, p = 0.071; Std. beta = 0.36, 95%
## CI [-0.04, 0.75])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-13.20, 2.92], t(2008) = -1.25, p = 0.211; Std. beta = -0.06,
## 95% CI [-0.55, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -0.86, 95% CI [-23.34, 21.62], t(2008) = -0.07, p = 0.940; Std. beta = 0.63,
## 95% CI [-0.89, 2.15])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.54, 95% CI [-12.35, 25.42], t(2008) = 0.68, p = 0.497; Std. beta = 0.98,
## 95% CI [-0.16, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-29.46, 39.33], t(2008) = 0.28, p = 0.778; Std. beta = 0.29,
## 95% CI [-1.73, 2.31])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 15.39, 95% CI [-0.41, 31.19], t(2008) = 1.91, p = 0.056; Std. beta = 1.21,
## 95% CI [0.23, 2.19])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-14.67, 29.52], t(2008) = 0.66, p = 0.510; Std. beta = 0.47,
## 95% CI [-0.94, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.44, 95% CI [1.60, 35.27], t(2008) = 2.15, p = 0.032; Std. beta = 1.00, 95%
## CI [-0.04, 2.03])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.00, 95% CI [-20.85, 36.85], t(2008) = 0.54, p = 0.586; Std. beta = 0.83,
## 95% CI [-1.64, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.41, 95% CI [-66.10, -2.72], t(2008) = -2.13, p = 0.033; Std. beta = -2.23,
## 95% CI [-4.51, 0.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.32, 6.33], t(2008) = -1.09, p = 0.274; Std. beta = -0.26,
## 95% CI [-1.16, 0.65])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.30, 95% CI [-22.62, 41.23], t(2008) = 0.57, p = 0.568; Std. beta = 0.55,
## 95% CI [-1.33, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-28.75, 16.88], t(2008) = -0.51, p = 0.610; Std. beta = 0.20,
## 95% CI [-1.84, 2.24])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.49, 18.90], t(2008) = 0.26, p = 0.796; Std. beta = -0.03,
## 95% CI [-1.12, 1.05])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.53, 95% CI [-12.83, 13.88], t(2008) = 0.08, p = 0.938; Std. beta = 0.12,
## 95% CI [-0.75, 0.99])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-29.07, 32.26], t(2008) = 0.10, p = 0.919; Std. beta = 0.47,
## 95% CI [-1.37, 2.31])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -0.71, 95% CI [-11.18, 9.76], t(2008) = -0.13, p = 0.894; Std. beta = -0.23,
## 95% CI [-0.92, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.74, 95% CI [-36.41, 0.93], t(2008) = -1.86, p = 0.063; Std. beta = -0.17,
## 95% CI [-4.00, 3.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.24, 95% CI [-6.76, 17.24], t(2008) = 0.86, p = 0.392; Std. beta = 0.33, 95%
## CI [-0.41, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-11.77, 14.72], t(2008) = 0.22, p = 0.827; Std. beta = -0.37,
## 95% CI [-1.20, 0.46])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.53, 95% CI [-13.94, 22.99], t(2008) = 0.48, p = 0.631; Std. beta = -0.52,
## 95% CI [-2.51, 1.48])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.25, 95% CI [-35.75, 27.24], t(2008) = -0.26, p = 0.791; Std. beta = -0.21,
## 95% CI [-2.07, 1.65])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.56, 95% CI [-7.62, 20.74], t(2008) = 0.91, p = 0.364; Std. beta = 0.48, 95%
## CI [-0.37, 1.33])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-26.28, 21.75], t(2008) = -0.19, p = 0.853; Std. beta = -0.70,
## 95% CI [-2.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.56, 95% CI [-37.40, -1.73], t(2008) = -2.15, p = 0.032; Std. beta = -0.94,
## 95% CI [-2.13, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-10.69, 13.66], t(2008) = 0.24, p = 0.811; Std. beta = 0.10,
## 95% CI [-0.66, 0.86])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 1.22, 95% CI [-17.31, 19.74], t(2008) = 0.13, p = 0.897; Std. beta = 1.16,
## 95% CI [-7.79e-03, 2.34])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-25.52, 2.79], t(2008) = -1.57, p = 0.115; Std. beta = -0.36,
## 95% CI [-1.27, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.93, 95% CI [1.03, 32.83], t(2008) = 2.09, p = 0.037; Std. beta = 0.88, 95%
## CI [-0.10, 1.85])
## - The effect of site [38R] is statistically significant and positive (beta =
## 13.24, 95% CI [2.56, 23.91], t(2008) = 2.43, p = 0.015; Std. beta = 0.56, 95%
## CI [-0.09, 1.22])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 22.95, 95% CI [-8.82, 54.73], t(2008) = 1.42, p = 0.157; Std. beta = -2.59,
## 95% CI [-4.68, -0.49])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.55, 95% CI [1.22, 45.88], t(2008) = 2.07, p = 0.039; Std. beta = 1.46, 95%
## CI [0.02, 2.90])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-20.52, 16.17], t(2008) = -0.23, p = 0.816; Std. beta = 0.06,
## 95% CI [-1.21, 1.32])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.24, 95% CI [-9.86, 10.33], t(2008) = 0.05, p = 0.964; Std. beta = 0.23, 95%
## CI [-0.70, 1.16])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 1.78, 95% CI [-2.98, 6.54], t(2008) = 0.73, p = 0.463;
## Std. beta = 0.04, 95% CI [-0.07, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.50, 1.85], t(2008) = -0.29, p = 0.768; Std.
## beta = -8.74e-03, 95% CI [-0.07, 0.05])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 5.28e-03, 95% CI [-2.21, 2.22], t(2008) =
## 4.67e-03, p = 0.996; Std. beta = 4.94e-04, 95% CI [-0.21, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## negative (beta = -0.08, 95% CI [-1.40, 1.23], t(2008) = -0.13, p = 0.899; Std.
## beta = -7.94e-03, 95% CI [-0.13, 0.11])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.05, 95% CI [-0.12, 0.01], t(2008) = -1.54, p = 0.124; Std.
## beta = -0.05, 95% CI [-0.10, 0.01])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.45, 95% CI [-0.88, 1.77], t(2008) =
## 0.66, p = 0.508; Std. beta = 0.04, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.42, 95% CI [-9.01, 11.84], t(2008) =
## 0.27, p = 0.790; Std. beta = 0.13, 95% CI [-0.84, 1.11])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.44, 95% CI [-1.88, 4.75], t(2008) =
## 0.85, p = 0.396; Std. beta = 0.13, 95% CI [-0.18, 0.44])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.25, 95% CI [-43.28, 14.78], t(2008) = -0.96, p = 0.336;
## Std. beta = -1.33, 95% CI [-4.04, 1.38])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-8.24, 12.14], t(2008) = 0.38, p = 0.707; Std.
## beta = 0.18, 95% CI [-0.77, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.41, 95% CI [-15.42, 6.59], t(2008) = -0.79, p = 0.431; Std.
## beta = -0.41, 95% CI [-1.44, 0.62])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-12.62, 11.97], t(2008) = -0.05, p = 0.958;
## Std. beta = -0.03, 95% CI [-1.18, 1.12])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.14, 95% CI [-6.06, -0.22], t(2008) = -2.11, p = 0.035; Std.
## beta = -0.29, 95% CI [-0.57, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -5.92, 95% CI [-14.44, 2.60], t(2008) = -1.36, p = 0.173; Std.
## beta = -0.55, 95% CI [-1.35, 0.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-2.49, 2.18], t(2008) = -0.13, p = 0.896; Std.
## beta = -0.01, 95% CI [-0.23, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-6.71, 1.74], t(2008) = -1.15, p = 0.249; Std.
## beta = -0.23, 95% CI [-0.63, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.69, 95% CI [0.32, 5.05], t(2008) = 2.22, p = 0.026; Std.
## beta = 0.25, 95% CI [0.03, 0.47])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.59, 95% CI [0.47, 14.71], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.71, 95% CI [0.04, 1.37])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-2.19, 2.49], t(2008) = 0.13, p = 0.898; Std.
## beta = 0.01, 95% CI [-0.20, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-0.38, 6.13], t(2008) = 1.73, p = 0.084; Std.
## beta = 0.27, 95% CI [-0.04, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 8.06, 95% CI [-5.19, 21.32], t(2008) = 1.19, p = 0.233; Std.
## beta = 0.75, 95% CI [-0.49, 1.99])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.10, 95% CI [0.57, 13.64], t(2008) = 2.13, p = 0.033; Std.
## beta = 0.66, 95% CI [0.05, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-2.09, 9.38], t(2008) = 1.25, p = 0.213; Std.
## beta = 0.34, 95% CI [-0.20, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.37, 95% CI [-7.84, 8.59], t(2008) = 0.09, p = 0.929; Std.
## beta = 0.03, 95% CI [-0.73, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-9.09, 7.10], t(2008) = -0.24, p = 0.810; Std.
## beta = -0.09, 95% CI [-0.85, 0.66])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-33.07, 41.51], t(2008) = 0.22, p = 0.824; Std.
## beta = 0.39, 95% CI [-3.09, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-24.98, 19.86], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.24, 95% CI [-2.33, 1.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-2.89, 7.92], t(2008) = 0.91, p = 0.362; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-14.83, 27.83], t(2008) = 0.60, p = 0.550; Std.
## beta = 0.61, 95% CI [-1.39, 2.60])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-9.60, 5.73], t(2008) = -0.50, p = 0.620; Std.
## beta = -0.18, 95% CI [-0.90, 0.54])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-5.33, 7.55], t(2008) = 0.34, p = 0.736; Std.
## beta = 0.10, 95% CI [-0.50, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.55, 13.43], t(2008) = 0.97, p = 0.333; Std.
## beta = 0.41, 95% CI [-0.42, 1.25])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-7.67, 3.31], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.20, 95% CI [-0.72, 0.31])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 10.32, 95% CI [-38.35, 58.99], t(2008) = 0.42, p = 0.678; Std.
## beta = 0.96, 95% CI [-3.58, 5.51])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.24, 95% CI [-4.37, 4.85], t(2008) = 0.10, p = 0.920; Std.
## beta = 0.02, 95% CI [-0.41, 0.45])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.41, 95% CI [-10.95, 0.13], t(2008) = -1.92, p = 0.056; Std.
## beta = -0.51, 95% CI [-1.02, 0.01])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-31.04, 12.54], t(2008) = -0.83, p = 0.405;
## Std. beta = -0.86, 95% CI [-2.90, 1.17])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-9.08, 10.01], t(2008) = 0.10, p = 0.923; Std.
## beta = 0.04, 95% CI [-0.85, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-2.88, 5.18], t(2008) = 0.56, p = 0.575; Std.
## beta = 0.11, 95% CI [-0.27, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.70, 95% CI [-17.61, 4.21], t(2008) = -1.20, p = 0.228; Std.
## beta = -0.63, 95% CI [-1.65, 0.39])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-6.05, 10.86], t(2008) = 0.56, p = 0.577; Std.
## beta = 0.22, 95% CI [-0.57, 1.01])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.65, 4.94], t(2008) = 0.06, p = 0.954; Std.
## beta = 0.01, 95% CI [-0.43, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.94, 95% CI [4.64, 21.24], t(2008) = 3.06, p = 0.002; Std.
## beta = 1.21, 95% CI [0.43, 1.98])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-2.07, 9.26], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.34, 95% CI [-0.19, 0.86])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.05, 4.29], t(2008) = -0.48, p = 0.634; Std.
## beta = -0.13, 95% CI [-0.66, 0.40])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-6.24, 1.20], t(2008) = -1.33, p = 0.184; Std.
## beta = -0.24, 95% CI [-0.58, 0.11])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.58, 95% CI [-63.61, -29.55], t(2008) = -5.36, p < .001;
## Std. beta = -4.35, 95% CI [-5.94, -2.76])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.92, 95% CI [-8.06, 9.91], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-8.75, 13.17], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.21, 95% CI [-0.82, 1.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-8.10, 13.21], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.76, 1.23])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.Linear mixed models with random intercept and slope will be used to evaluate the impact of PM During Disease on FVC decline.
FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*PM_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14569.7
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3285 -0.4401 -0.0176 0.4476 4.5225
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 256.81 16.025
## time_firstPFT 13.03 3.610 -0.12
## Residual 25.58 5.057
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 63.99339 4.67219 13.697
## time_firstPFT -3.30735 1.82334 -1.814
## PM_5yrPreCensor -0.39100 0.39339 -0.994
## site02R -8.73673 16.85011 -0.518
## site03R 12.25607 12.15616 1.008
## site04R 2.38595 11.78864 0.202
## site05R -12.27288 9.77475 -1.256
## site06R 19.60929 11.96302 1.639
## site07R 11.28981 4.94618 2.283
## site09R 20.04796 11.94411 1.678
## site101 1.36624 3.70802 0.368
## site102 8.70477 6.77046 1.286
## site103 -3.03366 3.44662 -0.880
## site104 -7.96514 6.91887 -1.151
## site105 2.76088 3.65147 0.756
## site106 -5.13303 4.39938 -1.167
## site107 -6.85359 12.07607 -0.568
## site108 -2.19428 9.90914 -0.221
## site10R 12.63570 17.44540 0.724
## site11R 13.20070 7.49050 1.762
## site12R 9.54540 11.98178 0.797
## site13R 14.53168 8.97794 1.619
## site14R 5.54086 15.04912 0.368
## site15R -28.93505 16.90468 -1.712
## site16R -16.38158 7.61727 -2.151
## site17R 4.74986 16.89180 0.281
## site18R -0.51343 11.98705 -0.043
## site19R 5.83681 8.04415 0.726
## site20R 2.06030 7.13243 0.289
## site21R 3.39416 16.41998 0.207
## site22R 0.19045 5.37479 0.035
## site23R -11.85385 7.71686 -1.536
## site24R 4.29159 6.62759 0.648
## site25R 0.73273 7.01351 0.104
## site28R 0.06657 9.80551 0.007
## site29R -5.63480 16.79514 -0.336
## site31R 2.36087 7.65589 0.308
## site32R 10.62987 8.53138 1.246
## site33R -17.04205 8.48458 -2.009
## site34R 0.74679 6.60523 0.113
## site35R 3.72824 10.01937 0.372
## site36R -13.83378 7.64750 -1.809
## site37R 11.63993 8.41724 1.383
## site38R 10.96417 5.85365 1.873
## site39R 16.33447 16.83331 0.970
## site40R 27.95436 11.79062 2.371
## site41R -2.27144 9.79675 -0.232
## site42R -1.38511 5.30838 -0.261
## time_firstPFT:PM_5yrPreCensor -0.07467 0.15713 -0.475
## time_firstPFT:site02R -15.28298 14.72105 -1.038
## time_firstPFT:site03R 1.33802 5.04038 0.265
## time_firstPFT:site04R -5.29960 5.52044 -0.960
## time_firstPFT:site05R -1.08531 6.22152 -0.174
## time_firstPFT:site06R -3.13276 4.78417 -0.655
## time_firstPFT:site07R -4.18245 1.48162 -2.823
## time_firstPFT:site09R -6.65870 4.25724 -1.564
## time_firstPFT:site101 -1.06888 1.25516 -0.852
## time_firstPFT:site102 -3.01115 2.25994 -1.332
## time_firstPFT:site103 1.51709 1.25768 1.206
## time_firstPFT:site104 5.97325 3.55060 1.682
## time_firstPFT:site105 -0.68389 1.25357 -0.546
## time_firstPFT:site106 1.76657 1.66624 1.060
## time_firstPFT:site107 7.23786 6.72888 1.076
## time_firstPFT:site108 6.07447 3.19041 1.904
## time_firstPFT:site11R 2.86069 2.73140 1.047
## time_firstPFT:site12R -0.66717 4.13448 -0.161
## time_firstPFT:site13R -2.17103 4.05783 -0.535
## time_firstPFT:site14R 2.96557 18.91568 0.157
## time_firstPFT:site15R -3.18861 11.36499 -0.281
## time_firstPFT:site16R 2.05321 2.68356 0.765
## time_firstPFT:site18R 6.43478 10.76828 0.598
## time_firstPFT:site19R 2.86723 4.28250 0.670
## time_firstPFT:site20R 0.45362 3.21288 0.141
## time_firstPFT:site21R 4.27218 4.49212 0.951
## time_firstPFT:site22R -3.79089 2.69707 -1.406
## time_firstPFT:site23R 1.15020 5.02030 0.229
## time_firstPFT:site24R -0.38911 2.40380 -0.162
## time_firstPFT:site25R -6.71465 2.74276 -2.448
## time_firstPFT:site28R -11.63413 10.96035 -1.061
## time_firstPFT:site29R -0.96392 4.75299 -0.203
## time_firstPFT:site31R 0.36011 2.05521 0.175
## time_firstPFT:site32R -4.21120 3.28295 -1.283
## time_firstPFT:site33R 2.71581 3.87274 0.701
## time_firstPFT:site34R -0.88154 2.41039 -0.366
## time_firstPFT:site35R 11.28952 4.22457 2.672
## time_firstPFT:site36R 3.00364 2.87018 1.046
## time_firstPFT:site37R -2.60068 2.75263 -0.945
## time_firstPFT:site38R -3.34064 1.91486 -1.745
## time_firstPFT:site39R -46.57169 8.58137 -5.427
## time_firstPFT:site40R -0.46412 4.49722 -0.103
## time_firstPFT:site41R 0.87677 5.54133 0.158
## time_firstPFT:site42R 1.02500 5.39383 0.190##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.924
## Unadjusted ICC: 0.734report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## PM_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 63.99 (95% CI [54.83,
## 73.16], t(2068) = 13.70, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.31, 95% CI [-6.88, 0.27], t(2068) = -1.81, p = 0.070; Std. beta =
## -0.43, 95% CI [-0.55, -0.30])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2068) = -0.99, p = 0.320; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-41.78, 24.31], t(2068) = -0.52, p = 0.604; Std. beta = -1.88,
## 95% CI [-4.68, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-11.58, 36.10], t(2068) = 1.01, p = 0.313; Std. beta = 0.84,
## 95% CI [-0.58, 2.27])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-20.73, 25.50], t(2068) = 0.20, p = 0.840; Std. beta = -0.33,
## 95% CI [-1.85, 1.19])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.27, 95% CI [-31.44, 6.90], t(2068) = -1.26, p = 0.209; Std. beta = -0.82,
## 95% CI [-2.20, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.85, 43.07], t(2068) = 1.64, p = 0.101; Std. beta = 0.88,
## 95% CI [-0.62, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.29, 95% CI [1.59, 20.99], t(2068) = 2.28, p = 0.023; Std. beta = 0.29, 95%
## CI [-0.29, 0.88])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.05, 95% CI [-3.38, 43.47], t(2068) = 1.68, p = 0.093; Std. beta = 0.59,
## 95% CI [-0.88, 2.06])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-5.91, 8.64], t(2068) = 0.37, p = 0.713; Std. beta = -0.01, 95%
## CI [-0.46, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.70, 95% CI [-4.57, 21.98], t(2068) = 1.29, p = 0.199; Std. beta = 0.25, 95%
## CI [-0.56, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-9.79, 3.73], t(2068) = -0.88, p = 0.379; Std. beta = -0.04,
## 95% CI [-0.47, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.53, 5.60], t(2068) = -1.15, p = 0.250; Std. beta = 0.06,
## 95% CI [-0.87, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.40, 9.92], t(2068) = 0.76, p = 0.450; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-13.76, 3.49], t(2068) = -1.17, p = 0.243; Std. beta = -0.15,
## 95% CI [-0.67, 0.38])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-30.54, 16.83], t(2068) = -0.57, p = 0.570; Std. beta = 0.24,
## 95% CI [-1.36, 1.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.19, 95% CI [-21.63, 17.24], t(2068) = -0.22, p = 0.825; Std. beta = 0.41,
## 95% CI [-0.76, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.64, 95% CI [-21.58, 46.85], t(2068) = 0.72, p = 0.469; Std. beta = 0.75,
## 95% CI [-1.27, 2.76])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 13.20, 95% CI [-1.49, 27.89], t(2068) = 1.76, p = 0.078; Std. beta = 1.03,
## 95% CI [0.12, 1.95])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.55, 95% CI [-13.95, 33.04], t(2068) = 0.80, p = 0.426; Std. beta = 0.50,
## 95% CI [-0.97, 1.98])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.53, 95% CI [-3.08, 32.14], t(2068) = 1.62, p = 0.106; Std. beta = 0.66,
## 95% CI [-0.41, 1.74])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-23.97, 35.05], t(2068) = 0.37, p = 0.713; Std. beta = 0.59,
## 95% CI [-2.02, 3.21])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.94, 95% CI [-62.09, 4.22], t(2068) = -1.71, p = 0.087; Std. beta = -1.99,
## 95% CI [-4.38, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.38, 95% CI [-31.32, -1.44], t(2068) = -2.15, p = 0.032; Std. beta = -0.78,
## 95% CI [-1.72, 0.15])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-28.38, 37.88], t(2068) = 0.28, p = 0.779; Std. beta = 0.28,
## 95% CI [-1.67, 2.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.51, 95% CI [-24.02, 22.99], t(2068) = -0.04, p = 0.966; Std. beta = 0.54,
## 95% CI [-1.58, 2.66])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.84, 95% CI [-9.94, 21.61], t(2068) = 0.73, p = 0.468; Std. beta = 0.60, 95%
## CI [-0.48, 1.68])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.06, 95% CI [-11.93, 16.05], t(2068) = 0.29, p = 0.773; Std. beta = 0.16,
## 95% CI [-0.74, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-28.81, 35.60], t(2068) = 0.21, p = 0.836; Std. beta = 0.58,
## 95% CI [-1.33, 2.49])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.19, 95% CI [-10.35, 10.73], t(2068) = 0.04, p = 0.972; Std. beta = -0.33,
## 95% CI [-1.02, 0.37])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.85, 95% CI [-26.99, 3.28], t(2068) = -1.54, p = 0.125; Std. beta = -0.60,
## 95% CI [-1.74, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-8.71, 17.29], t(2068) = 0.65, p = 0.517; Std. beta = 0.22, 95%
## CI [-0.58, 1.02])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-13.02, 14.49], t(2068) = 0.10, p = 0.917; Std. beta = -0.56,
## 95% CI [-1.41, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.07, 95% CI [-19.16, 19.30], t(2068) = 6.79e-03, p = 0.995; Std. beta =
## -1.03, 95% CI [-3.10, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-38.57, 27.30], t(2068) = -0.34, p = 0.737; Std. beta = -0.42,
## 95% CI [-2.35, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-12.65, 17.37], t(2068) = 0.31, p = 0.758; Std. beta = 0.17,
## 95% CI [-0.72, 1.07])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-6.10, 27.36], t(2068) = 1.25, p = 0.213; Std. beta = 0.25,
## 95% CI [-0.79, 1.30])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.04, 95% CI [-33.68, -0.40], t(2068) = -2.01, p = 0.045; Std. beta = -0.76,
## 95% CI [-1.87, 0.35])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-12.21, 13.70], t(2068) = 0.11, p = 0.910; Std. beta = -0.03,
## 95% CI [-0.84, 0.77])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-15.92, 23.38], t(2068) = 0.37, p = 0.710; Std. beta = 1.23,
## 95% CI [-0.01, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.83, 1.16], t(2068) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.50, 0.40])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.64, 95% CI [-4.87, 28.15], t(2068) = 1.38, p = 0.167; Std. beta = 0.45,
## 95% CI [-0.55, 1.46])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.96, 95% CI [-0.52, 22.44], t(2068) = 1.87, p = 0.061; Std. beta = 0.35,
## 95% CI [-0.35, 1.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.33, 95% CI [-16.68, 49.35], t(2068) = 0.97, p = 0.332; Std. beta = -3.19,
## 95% CI [-5.36, -1.02])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.95, 95% CI [4.83, 51.08], t(2068) = 2.37, p = 0.018; Std. beta = 1.61, 95%
## CI [0.12, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-21.48, 16.94], t(2068) = -0.23, p = 0.817; Std. beta = -0.06,
## 95% CI [-1.38, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.39, 95% CI [-11.80, 9.03], t(2068) = -0.26, p = 0.794; Std. beta =
## 9.67e-03, 95% CI [-0.96, 0.98])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.07, 95% CI [-0.38, 0.23], t(2068) =
## -0.48, p = 0.635; Std. beta = -0.02, 95% CI [-0.12, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.28, 95% CI [-44.15, 13.59], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.64, 95% CI [-4.74, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.55, 11.22], t(2068) = 0.27, p = 0.791; Std.
## beta = 0.14, 95% CI [-0.92, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.30, 95% CI [-16.13, 5.53], t(2068) = -0.96, p = 0.337; Std.
## beta = -0.57, 95% CI [-1.73, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-13.29, 11.12], t(2068) = -0.17, p = 0.862;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-12.52, 6.25], t(2068) = -0.65, p = 0.513; Std.
## beta = -0.34, 95% CI [-1.34, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.18, 95% CI [-7.09, -1.28], t(2068) = -2.82, p = 0.005; Std.
## beta = -0.45, 95% CI [-0.76, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.66, 95% CI [-15.01, 1.69], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.53, 1.39], t(2068) = -0.85, p = 0.395; Std.
## beta = -0.11, 95% CI [-0.38, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-7.44, 1.42], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.32, 95% CI [-0.80, 0.15])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.95, 3.98], t(2068) = 1.21, p = 0.228; Std.
## beta = 0.16, 95% CI [-0.10, 0.43])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.97, 95% CI [-0.99, 12.94], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.64, 95% CI [-0.11, 1.39])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.14, 1.77], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.07, 95% CI [-0.34, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-1.50, 5.03], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.19, 95% CI [-0.16, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.24, 95% CI [-5.96, 20.43], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.78, 95% CI [-0.64, 2.20])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.07, 95% CI [-0.18, 12.33], t(2068) = 1.90, p = 0.057; Std.
## beta = 0.65, 95% CI [-0.02, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.86, 95% CI [-2.50, 8.22], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.31, 95% CI [-0.27, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-8.78, 7.44], t(2068) = -0.16, p = 0.872; Std.
## beta = -0.07, 95% CI [-0.94, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-10.13, 5.79], t(2068) = -0.54, p = 0.593; Std.
## beta = -0.23, 95% CI [-1.09, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-34.13, 40.06], t(2068) = 0.16, p = 0.875; Std.
## beta = 0.32, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-25.48, 19.10], t(2068) = -0.28, p = 0.779;
## Std. beta = -0.34, 95% CI [-2.74, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.05, 95% CI [-3.21, 7.32], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.22, 95% CI [-0.34, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-14.68, 27.55], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-5.53, 11.27], t(2068) = 0.67, p = 0.503; Std.
## beta = 0.31, 95% CI [-0.59, 1.21])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-5.85, 6.75], t(2068) = 0.14, p = 0.888; Std.
## beta = 0.05, 95% CI [-0.63, 0.73])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.27, 95% CI [-4.54, 13.08], t(2068) = 0.95, p = 0.342; Std.
## beta = 0.46, 95% CI [-0.49, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-9.08, 1.50], t(2068) = -1.41, p = 0.160; Std.
## beta = -0.41, 95% CI [-0.98, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-8.70, 11.00], t(2068) = 0.23, p = 0.819; Std.
## beta = 0.12, 95% CI [-0.93, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.10, 4.33], t(2068) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.71, 95% CI [-12.09, -1.34], t(2068) = -2.45, p = 0.014;
## Std. beta = -0.72, 95% CI [-1.30, -0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.63, 95% CI [-33.13, 9.86], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-10.29, 8.36], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.10, 95% CI [-1.10, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-3.67, 4.39], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.04, 95% CI [-0.39, 0.47])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-10.65, 2.23], t(2068) = -1.28, p = 0.200; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-4.88, 10.31], t(2068) = 0.70, p = 0.483; Std.
## beta = 0.29, 95% CI [-0.52, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-5.61, 3.85], t(2068) = -0.37, p = 0.715; Std.
## beta = -0.09, 95% CI [-0.60, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.29, 95% CI [3.00, 19.57], t(2068) = 2.67, p = 0.008; Std.
## beta = 1.21, 95% CI [0.32, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-2.63, 8.63], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.32, 95% CI [-0.28, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-8.00, 2.80], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.10, 0.41], t(2068) = -1.74, p = 0.081; Std.
## beta = -0.36, 95% CI [-0.76, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.57, 95% CI [-63.40, -29.74], t(2068) = -5.43, p < .001;
## Std. beta = -5.00, 95% CI [-6.81, -3.20])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-9.28, 8.36], t(2068) = -0.10, p = 0.918; Std.
## beta = -0.05, 95% CI [-1.00, 0.90])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-9.99, 11.74], t(2068) = 0.16, p = 0.874; Std.
## beta = 0.09, 95% CI [-1.07, 1.26])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-9.55, 11.60], t(2068) = 0.19, p = 0.849; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## PM_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to PM_5yrPreCensor = 0, is at 63.99 (95% CI [54.83, 73.16],
## t(2068) = 13.70, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.31, 95% CI [-6.88, 0.27], t(2068) = -1.81, p = 0.070; Std. beta =
## -0.43, 95% CI [-0.55, -0.30])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2068) = -0.99, p = 0.320; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-41.78, 24.31], t(2068) = -0.52, p = 0.604; Std. beta = -1.88,
## 95% CI [-4.68, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-11.58, 36.10], t(2068) = 1.01, p = 0.313; Std. beta = 0.84,
## 95% CI [-0.58, 2.27])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-20.73, 25.50], t(2068) = 0.20, p = 0.840; Std. beta = -0.33,
## 95% CI [-1.85, 1.19])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.27, 95% CI [-31.44, 6.90], t(2068) = -1.26, p = 0.209; Std. beta = -0.82,
## 95% CI [-2.20, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.85, 43.07], t(2068) = 1.64, p = 0.101; Std. beta = 0.88,
## 95% CI [-0.62, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.29, 95% CI [1.59, 20.99], t(2068) = 2.28, p = 0.023; Std. beta = 0.29, 95%
## CI [-0.29, 0.88])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.05, 95% CI [-3.38, 43.47], t(2068) = 1.68, p = 0.093; Std. beta = 0.59,
## 95% CI [-0.88, 2.06])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-5.91, 8.64], t(2068) = 0.37, p = 0.713; Std. beta = -0.01, 95%
## CI [-0.46, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.70, 95% CI [-4.57, 21.98], t(2068) = 1.29, p = 0.199; Std. beta = 0.25, 95%
## CI [-0.56, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-9.79, 3.73], t(2068) = -0.88, p = 0.379; Std. beta = -0.04,
## 95% CI [-0.47, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.53, 5.60], t(2068) = -1.15, p = 0.250; Std. beta = 0.06,
## 95% CI [-0.87, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.40, 9.92], t(2068) = 0.76, p = 0.450; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-13.76, 3.49], t(2068) = -1.17, p = 0.243; Std. beta = -0.15,
## 95% CI [-0.67, 0.38])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-30.54, 16.83], t(2068) = -0.57, p = 0.570; Std. beta = 0.24,
## 95% CI [-1.36, 1.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.19, 95% CI [-21.63, 17.24], t(2068) = -0.22, p = 0.825; Std. beta = 0.41,
## 95% CI [-0.76, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.64, 95% CI [-21.58, 46.85], t(2068) = 0.72, p = 0.469; Std. beta = 0.75,
## 95% CI [-1.27, 2.76])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 13.20, 95% CI [-1.49, 27.89], t(2068) = 1.76, p = 0.078; Std. beta = 1.03,
## 95% CI [0.12, 1.95])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.55, 95% CI [-13.95, 33.04], t(2068) = 0.80, p = 0.426; Std. beta = 0.50,
## 95% CI [-0.97, 1.98])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.53, 95% CI [-3.08, 32.14], t(2068) = 1.62, p = 0.106; Std. beta = 0.66,
## 95% CI [-0.41, 1.74])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-23.97, 35.05], t(2068) = 0.37, p = 0.713; Std. beta = 0.59,
## 95% CI [-2.02, 3.21])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.94, 95% CI [-62.09, 4.22], t(2068) = -1.71, p = 0.087; Std. beta = -1.99,
## 95% CI [-4.38, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.38, 95% CI [-31.32, -1.44], t(2068) = -2.15, p = 0.032; Std. beta = -0.78,
## 95% CI [-1.72, 0.15])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-28.38, 37.88], t(2068) = 0.28, p = 0.779; Std. beta = 0.28,
## 95% CI [-1.67, 2.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.51, 95% CI [-24.02, 22.99], t(2068) = -0.04, p = 0.966; Std. beta = 0.54,
## 95% CI [-1.58, 2.66])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.84, 95% CI [-9.94, 21.61], t(2068) = 0.73, p = 0.468; Std. beta = 0.60, 95%
## CI [-0.48, 1.68])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.06, 95% CI [-11.93, 16.05], t(2068) = 0.29, p = 0.773; Std. beta = 0.16,
## 95% CI [-0.74, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-28.81, 35.60], t(2068) = 0.21, p = 0.836; Std. beta = 0.58,
## 95% CI [-1.33, 2.49])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.19, 95% CI [-10.35, 10.73], t(2068) = 0.04, p = 0.972; Std. beta = -0.33,
## 95% CI [-1.02, 0.37])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.85, 95% CI [-26.99, 3.28], t(2068) = -1.54, p = 0.125; Std. beta = -0.60,
## 95% CI [-1.74, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-8.71, 17.29], t(2068) = 0.65, p = 0.517; Std. beta = 0.22, 95%
## CI [-0.58, 1.02])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-13.02, 14.49], t(2068) = 0.10, p = 0.917; Std. beta = -0.56,
## 95% CI [-1.41, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.07, 95% CI [-19.16, 19.30], t(2068) = 6.79e-03, p = 0.995; Std. beta =
## -1.03, 95% CI [-3.10, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-38.57, 27.30], t(2068) = -0.34, p = 0.737; Std. beta = -0.42,
## 95% CI [-2.35, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-12.65, 17.37], t(2068) = 0.31, p = 0.758; Std. beta = 0.17,
## 95% CI [-0.72, 1.07])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-6.10, 27.36], t(2068) = 1.25, p = 0.213; Std. beta = 0.25,
## 95% CI [-0.79, 1.30])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.04, 95% CI [-33.68, -0.40], t(2068) = -2.01, p = 0.045; Std. beta = -0.76,
## 95% CI [-1.87, 0.35])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-12.21, 13.70], t(2068) = 0.11, p = 0.910; Std. beta = -0.03,
## 95% CI [-0.84, 0.77])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-15.92, 23.38], t(2068) = 0.37, p = 0.710; Std. beta = 1.23,
## 95% CI [-0.01, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.83, 1.16], t(2068) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.50, 0.40])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.64, 95% CI [-4.87, 28.15], t(2068) = 1.38, p = 0.167; Std. beta = 0.45,
## 95% CI [-0.55, 1.46])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.96, 95% CI [-0.52, 22.44], t(2068) = 1.87, p = 0.061; Std. beta = 0.35,
## 95% CI [-0.35, 1.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.33, 95% CI [-16.68, 49.35], t(2068) = 0.97, p = 0.332; Std. beta = -3.19,
## 95% CI [-5.36, -1.02])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.95, 95% CI [4.83, 51.08], t(2068) = 2.37, p = 0.018; Std. beta = 1.61, 95%
## CI [0.12, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-21.48, 16.94], t(2068) = -0.23, p = 0.817; Std. beta = -0.06,
## 95% CI [-1.38, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.39, 95% CI [-11.80, 9.03], t(2068) = -0.26, p = 0.794; Std. beta =
## 9.67e-03, 95% CI [-0.96, 0.98])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.07, 95% CI [-0.38, 0.23], t(2068) =
## -0.48, p = 0.635; Std. beta = -0.02, 95% CI [-0.12, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.28, 95% CI [-44.15, 13.59], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.64, 95% CI [-4.74, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.55, 11.22], t(2068) = 0.27, p = 0.791; Std.
## beta = 0.14, 95% CI [-0.92, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.30, 95% CI [-16.13, 5.53], t(2068) = -0.96, p = 0.337; Std.
## beta = -0.57, 95% CI [-1.73, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-13.29, 11.12], t(2068) = -0.17, p = 0.862;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-12.52, 6.25], t(2068) = -0.65, p = 0.513; Std.
## beta = -0.34, 95% CI [-1.34, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.18, 95% CI [-7.09, -1.28], t(2068) = -2.82, p = 0.005; Std.
## beta = -0.45, 95% CI [-0.76, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.66, 95% CI [-15.01, 1.69], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.53, 1.39], t(2068) = -0.85, p = 0.395; Std.
## beta = -0.11, 95% CI [-0.38, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-7.44, 1.42], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.32, 95% CI [-0.80, 0.15])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.95, 3.98], t(2068) = 1.21, p = 0.228; Std.
## beta = 0.16, 95% CI [-0.10, 0.43])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.97, 95% CI [-0.99, 12.94], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.64, 95% CI [-0.11, 1.39])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.14, 1.77], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.07, 95% CI [-0.34, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-1.50, 5.03], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.19, 95% CI [-0.16, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.24, 95% CI [-5.96, 20.43], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.78, 95% CI [-0.64, 2.20])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.07, 95% CI [-0.18, 12.33], t(2068) = 1.90, p = 0.057; Std.
## beta = 0.65, 95% CI [-0.02, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.86, 95% CI [-2.50, 8.22], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.31, 95% CI [-0.27, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-8.78, 7.44], t(2068) = -0.16, p = 0.872; Std.
## beta = -0.07, 95% CI [-0.94, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-10.13, 5.79], t(2068) = -0.54, p = 0.593; Std.
## beta = -0.23, 95% CI [-1.09, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-34.13, 40.06], t(2068) = 0.16, p = 0.875; Std.
## beta = 0.32, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-25.48, 19.10], t(2068) = -0.28, p = 0.779;
## Std. beta = -0.34, 95% CI [-2.74, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.05, 95% CI [-3.21, 7.32], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.22, 95% CI [-0.34, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-14.68, 27.55], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-5.53, 11.27], t(2068) = 0.67, p = 0.503; Std.
## beta = 0.31, 95% CI [-0.59, 1.21])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-5.85, 6.75], t(2068) = 0.14, p = 0.888; Std.
## beta = 0.05, 95% CI [-0.63, 0.73])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.27, 95% CI [-4.54, 13.08], t(2068) = 0.95, p = 0.342; Std.
## beta = 0.46, 95% CI [-0.49, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-9.08, 1.50], t(2068) = -1.41, p = 0.160; Std.
## beta = -0.41, 95% CI [-0.98, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-8.70, 11.00], t(2068) = 0.23, p = 0.819; Std.
## beta = 0.12, 95% CI [-0.93, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.10, 4.33], t(2068) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.71, 95% CI [-12.09, -1.34], t(2068) = -2.45, p = 0.014;
## Std. beta = -0.72, 95% CI [-1.30, -0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.63, 95% CI [-33.13, 9.86], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-10.29, 8.36], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.10, 95% CI [-1.10, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-3.67, 4.39], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.04, 95% CI [-0.39, 0.47])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-10.65, 2.23], t(2068) = -1.28, p = 0.200; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-4.88, 10.31], t(2068) = 0.70, p = 0.483; Std.
## beta = 0.29, 95% CI [-0.52, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-5.61, 3.85], t(2068) = -0.37, p = 0.715; Std.
## beta = -0.09, 95% CI [-0.60, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.29, 95% CI [3.00, 19.57], t(2068) = 2.67, p = 0.008; Std.
## beta = 1.21, 95% CI [0.32, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-2.63, 8.63], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.32, 95% CI [-0.28, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-8.00, 2.80], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.10, 0.41], t(2068) = -1.74, p = 0.081; Std.
## beta = -0.36, 95% CI [-0.76, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.57, 95% CI [-63.40, -29.74], t(2068) = -5.43, p < .001;
## Std. beta = -5.00, 95% CI [-6.81, -3.20])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-9.28, 8.36], t(2068) = -0.10, p = 0.918; Std.
## beta = -0.05, 95% CI [-1.00, 0.90])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-9.99, 11.74], t(2068) = 0.16, p = 0.874; Std.
## beta = 0.09, 95% CI [-1.07, 1.26])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-9.55, 11.60], t(2068) = 0.19, p = 0.849; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 63.99 (95% CI [54.83, 73.16], t(2068) = 13.70, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.31, 95% CI [-6.88, 0.27], t(2068) = -1.81, p = 0.070; Std. beta =
## -0.43, 95% CI [-0.55, -0.30])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2068) = -0.99, p = 0.320; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-41.78, 24.31], t(2068) = -0.52, p = 0.604; Std. beta = -1.88,
## 95% CI [-4.68, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-11.58, 36.10], t(2068) = 1.01, p = 0.313; Std. beta = 0.84,
## 95% CI [-0.58, 2.27])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-20.73, 25.50], t(2068) = 0.20, p = 0.840; Std. beta = -0.33,
## 95% CI [-1.85, 1.19])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.27, 95% CI [-31.44, 6.90], t(2068) = -1.26, p = 0.209; Std. beta = -0.82,
## 95% CI [-2.20, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.85, 43.07], t(2068) = 1.64, p = 0.101; Std. beta = 0.88,
## 95% CI [-0.62, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.29, 95% CI [1.59, 20.99], t(2068) = 2.28, p = 0.023; Std. beta = 0.29, 95%
## CI [-0.29, 0.88])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.05, 95% CI [-3.38, 43.47], t(2068) = 1.68, p = 0.093; Std. beta = 0.59,
## 95% CI [-0.88, 2.06])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-5.91, 8.64], t(2068) = 0.37, p = 0.713; Std. beta = -0.01, 95%
## CI [-0.46, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.70, 95% CI [-4.57, 21.98], t(2068) = 1.29, p = 0.199; Std. beta = 0.25, 95%
## CI [-0.56, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-9.79, 3.73], t(2068) = -0.88, p = 0.379; Std. beta = -0.04,
## 95% CI [-0.47, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.53, 5.60], t(2068) = -1.15, p = 0.250; Std. beta = 0.06,
## 95% CI [-0.87, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.40, 9.92], t(2068) = 0.76, p = 0.450; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-13.76, 3.49], t(2068) = -1.17, p = 0.243; Std. beta = -0.15,
## 95% CI [-0.67, 0.38])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-30.54, 16.83], t(2068) = -0.57, p = 0.570; Std. beta = 0.24,
## 95% CI [-1.36, 1.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.19, 95% CI [-21.63, 17.24], t(2068) = -0.22, p = 0.825; Std. beta = 0.41,
## 95% CI [-0.76, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.64, 95% CI [-21.58, 46.85], t(2068) = 0.72, p = 0.469; Std. beta = 0.75,
## 95% CI [-1.27, 2.76])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 13.20, 95% CI [-1.49, 27.89], t(2068) = 1.76, p = 0.078; Std. beta = 1.03,
## 95% CI [0.12, 1.95])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.55, 95% CI [-13.95, 33.04], t(2068) = 0.80, p = 0.426; Std. beta = 0.50,
## 95% CI [-0.97, 1.98])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.53, 95% CI [-3.08, 32.14], t(2068) = 1.62, p = 0.106; Std. beta = 0.66,
## 95% CI [-0.41, 1.74])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-23.97, 35.05], t(2068) = 0.37, p = 0.713; Std. beta = 0.59,
## 95% CI [-2.02, 3.21])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.94, 95% CI [-62.09, 4.22], t(2068) = -1.71, p = 0.087; Std. beta = -1.99,
## 95% CI [-4.38, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.38, 95% CI [-31.32, -1.44], t(2068) = -2.15, p = 0.032; Std. beta = -0.78,
## 95% CI [-1.72, 0.15])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-28.38, 37.88], t(2068) = 0.28, p = 0.779; Std. beta = 0.28,
## 95% CI [-1.67, 2.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.51, 95% CI [-24.02, 22.99], t(2068) = -0.04, p = 0.966; Std. beta = 0.54,
## 95% CI [-1.58, 2.66])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.84, 95% CI [-9.94, 21.61], t(2068) = 0.73, p = 0.468; Std. beta = 0.60, 95%
## CI [-0.48, 1.68])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.06, 95% CI [-11.93, 16.05], t(2068) = 0.29, p = 0.773; Std. beta = 0.16,
## 95% CI [-0.74, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-28.81, 35.60], t(2068) = 0.21, p = 0.836; Std. beta = 0.58,
## 95% CI [-1.33, 2.49])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.19, 95% CI [-10.35, 10.73], t(2068) = 0.04, p = 0.972; Std. beta = -0.33,
## 95% CI [-1.02, 0.37])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.85, 95% CI [-26.99, 3.28], t(2068) = -1.54, p = 0.125; Std. beta = -0.60,
## 95% CI [-1.74, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-8.71, 17.29], t(2068) = 0.65, p = 0.517; Std. beta = 0.22, 95%
## CI [-0.58, 1.02])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-13.02, 14.49], t(2068) = 0.10, p = 0.917; Std. beta = -0.56,
## 95% CI [-1.41, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.07, 95% CI [-19.16, 19.30], t(2068) = 6.79e-03, p = 0.995; Std. beta =
## -1.03, 95% CI [-3.10, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-38.57, 27.30], t(2068) = -0.34, p = 0.737; Std. beta = -0.42,
## 95% CI [-2.35, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-12.65, 17.37], t(2068) = 0.31, p = 0.758; Std. beta = 0.17,
## 95% CI [-0.72, 1.07])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-6.10, 27.36], t(2068) = 1.25, p = 0.213; Std. beta = 0.25,
## 95% CI [-0.79, 1.30])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.04, 95% CI [-33.68, -0.40], t(2068) = -2.01, p = 0.045; Std. beta = -0.76,
## 95% CI [-1.87, 0.35])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-12.21, 13.70], t(2068) = 0.11, p = 0.910; Std. beta = -0.03,
## 95% CI [-0.84, 0.77])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-15.92, 23.38], t(2068) = 0.37, p = 0.710; Std. beta = 1.23,
## 95% CI [-0.01, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.83, 1.16], t(2068) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.50, 0.40])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.64, 95% CI [-4.87, 28.15], t(2068) = 1.38, p = 0.167; Std. beta = 0.45,
## 95% CI [-0.55, 1.46])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.96, 95% CI [-0.52, 22.44], t(2068) = 1.87, p = 0.061; Std. beta = 0.35,
## 95% CI [-0.35, 1.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.33, 95% CI [-16.68, 49.35], t(2068) = 0.97, p = 0.332; Std. beta = -3.19,
## 95% CI [-5.36, -1.02])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.95, 95% CI [4.83, 51.08], t(2068) = 2.37, p = 0.018; Std. beta = 1.61, 95%
## CI [0.12, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-21.48, 16.94], t(2068) = -0.23, p = 0.817; Std. beta = -0.06,
## 95% CI [-1.38, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.39, 95% CI [-11.80, 9.03], t(2068) = -0.26, p = 0.794; Std. beta =
## 9.67e-03, 95% CI [-0.96, 0.98])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.07, 95% CI [-0.38, 0.23], t(2068) =
## -0.48, p = 0.635; Std. beta = -0.02, 95% CI [-0.12, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.28, 95% CI [-44.15, 13.59], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.64, 95% CI [-4.74, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.55, 11.22], t(2068) = 0.27, p = 0.791; Std.
## beta = 0.14, 95% CI [-0.92, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.30, 95% CI [-16.13, 5.53], t(2068) = -0.96, p = 0.337; Std.
## beta = -0.57, 95% CI [-1.73, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-13.29, 11.12], t(2068) = -0.17, p = 0.862;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-12.52, 6.25], t(2068) = -0.65, p = 0.513; Std.
## beta = -0.34, 95% CI [-1.34, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.18, 95% CI [-7.09, -1.28], t(2068) = -2.82, p = 0.005; Std.
## beta = -0.45, 95% CI [-0.76, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.66, 95% CI [-15.01, 1.69], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.53, 1.39], t(2068) = -0.85, p = 0.395; Std.
## beta = -0.11, 95% CI [-0.38, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-7.44, 1.42], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.32, 95% CI [-0.80, 0.15])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.95, 3.98], t(2068) = 1.21, p = 0.228; Std.
## beta = 0.16, 95% CI [-0.10, 0.43])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.97, 95% CI [-0.99, 12.94], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.64, 95% CI [-0.11, 1.39])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.14, 1.77], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.07, 95% CI [-0.34, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-1.50, 5.03], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.19, 95% CI [-0.16, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.24, 95% CI [-5.96, 20.43], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.78, 95% CI [-0.64, 2.20])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.07, 95% CI [-0.18, 12.33], t(2068) = 1.90, p = 0.057; Std.
## beta = 0.65, 95% CI [-0.02, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.86, 95% CI [-2.50, 8.22], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.31, 95% CI [-0.27, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-8.78, 7.44], t(2068) = -0.16, p = 0.872; Std.
## beta = -0.07, 95% CI [-0.94, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-10.13, 5.79], t(2068) = -0.54, p = 0.593; Std.
## beta = -0.23, 95% CI [-1.09, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-34.13, 40.06], t(2068) = 0.16, p = 0.875; Std.
## beta = 0.32, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-25.48, 19.10], t(2068) = -0.28, p = 0.779;
## Std. beta = -0.34, 95% CI [-2.74, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.05, 95% CI [-3.21, 7.32], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.22, 95% CI [-0.34, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-14.68, 27.55], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-5.53, 11.27], t(2068) = 0.67, p = 0.503; Std.
## beta = 0.31, 95% CI [-0.59, 1.21])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-5.85, 6.75], t(2068) = 0.14, p = 0.888; Std.
## beta = 0.05, 95% CI [-0.63, 0.73])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.27, 95% CI [-4.54, 13.08], t(2068) = 0.95, p = 0.342; Std.
## beta = 0.46, 95% CI [-0.49, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-9.08, 1.50], t(2068) = -1.41, p = 0.160; Std.
## beta = -0.41, 95% CI [-0.98, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-8.70, 11.00], t(2068) = 0.23, p = 0.819; Std.
## beta = 0.12, 95% CI [-0.93, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.10, 4.33], t(2068) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.71, 95% CI [-12.09, -1.34], t(2068) = -2.45, p = 0.014;
## Std. beta = -0.72, 95% CI [-1.30, -0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.63, 95% CI [-33.13, 9.86], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-10.29, 8.36], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.10, 95% CI [-1.10, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-3.67, 4.39], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.04, 95% CI [-0.39, 0.47])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-10.65, 2.23], t(2068) = -1.28, p = 0.200; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-4.88, 10.31], t(2068) = 0.70, p = 0.483; Std.
## beta = 0.29, 95% CI [-0.52, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-5.61, 3.85], t(2068) = -0.37, p = 0.715; Std.
## beta = -0.09, 95% CI [-0.60, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.29, 95% CI [3.00, 19.57], t(2068) = 2.67, p = 0.008; Std.
## beta = 1.21, 95% CI [0.32, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-2.63, 8.63], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.32, 95% CI [-0.28, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-8.00, 2.80], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.10, 0.41], t(2068) = -1.74, p = 0.081; Std.
## beta = -0.36, 95% CI [-0.76, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.57, 95% CI [-63.40, -29.74], t(2068) = -5.43, p < .001;
## Std. beta = -5.00, 95% CI [-6.81, -3.20])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-9.28, 8.36], t(2068) = -0.10, p = 0.918; Std.
## beta = -0.05, 95% CI [-1.00, 0.90])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-9.99, 11.74], t(2068) = 0.16, p = 0.874; Std.
## beta = 0.09, 95% CI [-1.07, 1.26])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-9.55, 11.60], t(2068) = 0.19, p = 0.849; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to cohort = CARE-PF, is at 63.99 (95% CI [54.83, 73.16], t(2068)
## = 13.70, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.31, 95% CI [-6.88, 0.27], t(2068) = -1.81, p = 0.070; Std. beta =
## -0.43, 95% CI [-0.55, -0.30])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2068) = -0.99, p = 0.320; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-41.78, 24.31], t(2068) = -0.52, p = 0.604; Std. beta = -1.88,
## 95% CI [-4.68, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-11.58, 36.10], t(2068) = 1.01, p = 0.313; Std. beta = 0.84,
## 95% CI [-0.58, 2.27])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-20.73, 25.50], t(2068) = 0.20, p = 0.840; Std. beta = -0.33,
## 95% CI [-1.85, 1.19])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.27, 95% CI [-31.44, 6.90], t(2068) = -1.26, p = 0.209; Std. beta = -0.82,
## 95% CI [-2.20, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.61, 95% CI [-3.85, 43.07], t(2068) = 1.64, p = 0.101; Std. beta = 0.88,
## 95% CI [-0.62, 2.37])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.29, 95% CI [1.59, 20.99], t(2068) = 2.28, p = 0.023; Std. beta = 0.29, 95%
## CI [-0.29, 0.88])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.05, 95% CI [-3.38, 43.47], t(2068) = 1.68, p = 0.093; Std. beta = 0.59,
## 95% CI [-0.88, 2.06])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-5.91, 8.64], t(2068) = 0.37, p = 0.713; Std. beta = -0.01, 95%
## CI [-0.46, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.70, 95% CI [-4.57, 21.98], t(2068) = 1.29, p = 0.199; Std. beta = 0.25, 95%
## CI [-0.56, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-9.79, 3.73], t(2068) = -0.88, p = 0.379; Std. beta = -0.04,
## 95% CI [-0.47, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.53, 5.60], t(2068) = -1.15, p = 0.250; Std. beta = 0.06,
## 95% CI [-0.87, 1.00])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.40, 9.92], t(2068) = 0.76, p = 0.450; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-13.76, 3.49], t(2068) = -1.17, p = 0.243; Std. beta = -0.15,
## 95% CI [-0.67, 0.38])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-30.54, 16.83], t(2068) = -0.57, p = 0.570; Std. beta = 0.24,
## 95% CI [-1.36, 1.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.19, 95% CI [-21.63, 17.24], t(2068) = -0.22, p = 0.825; Std. beta = 0.41,
## 95% CI [-0.76, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 12.64, 95% CI [-21.58, 46.85], t(2068) = 0.72, p = 0.469; Std. beta = 0.75,
## 95% CI [-1.27, 2.76])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 13.20, 95% CI [-1.49, 27.89], t(2068) = 1.76, p = 0.078; Std. beta = 1.03,
## 95% CI [0.12, 1.95])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 9.55, 95% CI [-13.95, 33.04], t(2068) = 0.80, p = 0.426; Std. beta = 0.50,
## 95% CI [-0.97, 1.98])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.53, 95% CI [-3.08, 32.14], t(2068) = 1.62, p = 0.106; Std. beta = 0.66,
## 95% CI [-0.41, 1.74])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.54, 95% CI [-23.97, 35.05], t(2068) = 0.37, p = 0.713; Std. beta = 0.59,
## 95% CI [-2.02, 3.21])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -28.94, 95% CI [-62.09, 4.22], t(2068) = -1.71, p = 0.087; Std. beta = -1.99,
## 95% CI [-4.38, 0.40])
## - The effect of site [16R] is statistically significant and negative (beta =
## -16.38, 95% CI [-31.32, -1.44], t(2068) = -2.15, p = 0.032; Std. beta = -0.78,
## 95% CI [-1.72, 0.15])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-28.38, 37.88], t(2068) = 0.28, p = 0.779; Std. beta = 0.28,
## 95% CI [-1.67, 2.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.51, 95% CI [-24.02, 22.99], t(2068) = -0.04, p = 0.966; Std. beta = 0.54,
## 95% CI [-1.58, 2.66])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.84, 95% CI [-9.94, 21.61], t(2068) = 0.73, p = 0.468; Std. beta = 0.60, 95%
## CI [-0.48, 1.68])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.06, 95% CI [-11.93, 16.05], t(2068) = 0.29, p = 0.773; Std. beta = 0.16,
## 95% CI [-0.74, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-28.81, 35.60], t(2068) = 0.21, p = 0.836; Std. beta = 0.58,
## 95% CI [-1.33, 2.49])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.19, 95% CI [-10.35, 10.73], t(2068) = 0.04, p = 0.972; Std. beta = -0.33,
## 95% CI [-1.02, 0.37])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -11.85, 95% CI [-26.99, 3.28], t(2068) = -1.54, p = 0.125; Std. beta = -0.60,
## 95% CI [-1.74, 0.55])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-8.71, 17.29], t(2068) = 0.65, p = 0.517; Std. beta = 0.22, 95%
## CI [-0.58, 1.02])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.73, 95% CI [-13.02, 14.49], t(2068) = 0.10, p = 0.917; Std. beta = -0.56,
## 95% CI [-1.41, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.07, 95% CI [-19.16, 19.30], t(2068) = 6.79e-03, p = 0.995; Std. beta =
## -1.03, 95% CI [-3.10, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-38.57, 27.30], t(2068) = -0.34, p = 0.737; Std. beta = -0.42,
## 95% CI [-2.35, 1.51])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-12.65, 17.37], t(2068) = 0.31, p = 0.758; Std. beta = 0.17,
## 95% CI [-0.72, 1.07])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.63, 95% CI [-6.10, 27.36], t(2068) = 1.25, p = 0.213; Std. beta = 0.25,
## 95% CI [-0.79, 1.30])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.04, 95% CI [-33.68, -0.40], t(2068) = -2.01, p = 0.045; Std. beta = -0.76,
## 95% CI [-1.87, 0.35])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-12.21, 13.70], t(2068) = 0.11, p = 0.910; Std. beta = -0.03,
## 95% CI [-0.84, 0.77])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-15.92, 23.38], t(2068) = 0.37, p = 0.710; Std. beta = 1.23,
## 95% CI [-0.01, 2.46])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -13.83, 95% CI [-28.83, 1.16], t(2068) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.50, 0.40])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 11.64, 95% CI [-4.87, 28.15], t(2068) = 1.38, p = 0.167; Std. beta = 0.45,
## 95% CI [-0.55, 1.46])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.96, 95% CI [-0.52, 22.44], t(2068) = 1.87, p = 0.061; Std. beta = 0.35,
## 95% CI [-0.35, 1.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.33, 95% CI [-16.68, 49.35], t(2068) = 0.97, p = 0.332; Std. beta = -3.19,
## 95% CI [-5.36, -1.02])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.95, 95% CI [4.83, 51.08], t(2068) = 2.37, p = 0.018; Std. beta = 1.61, 95%
## CI [0.12, 3.09])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-21.48, 16.94], t(2068) = -0.23, p = 0.817; Std. beta = -0.06,
## 95% CI [-1.38, 1.27])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.39, 95% CI [-11.80, 9.03], t(2068) = -0.26, p = 0.794; Std. beta =
## 9.67e-03, 95% CI [-0.96, 0.98])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.07, 95% CI [-0.38, 0.23], t(2068) =
## -0.48, p = 0.635; Std. beta = -0.02, 95% CI [-0.12, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.28, 95% CI [-44.15, 13.59], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.64, 95% CI [-4.74, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.55, 11.22], t(2068) = 0.27, p = 0.791; Std.
## beta = 0.14, 95% CI [-0.92, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.30, 95% CI [-16.13, 5.53], t(2068) = -0.96, p = 0.337; Std.
## beta = -0.57, 95% CI [-1.73, 0.59])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-13.29, 11.12], t(2068) = -0.17, p = 0.862;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-12.52, 6.25], t(2068) = -0.65, p = 0.513; Std.
## beta = -0.34, 95% CI [-1.34, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.18, 95% CI [-7.09, -1.28], t(2068) = -2.82, p = 0.005; Std.
## beta = -0.45, 95% CI [-0.76, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.66, 95% CI [-15.01, 1.69], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.53, 1.39], t(2068) = -0.85, p = 0.395; Std.
## beta = -0.11, 95% CI [-0.38, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-7.44, 1.42], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.32, 95% CI [-0.80, 0.15])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.95, 3.98], t(2068) = 1.21, p = 0.228; Std.
## beta = 0.16, 95% CI [-0.10, 0.43])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.97, 95% CI [-0.99, 12.94], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.64, 95% CI [-0.11, 1.39])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.14, 1.77], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.07, 95% CI [-0.34, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-1.50, 5.03], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.19, 95% CI [-0.16, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.24, 95% CI [-5.96, 20.43], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.78, 95% CI [-0.64, 2.20])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.07, 95% CI [-0.18, 12.33], t(2068) = 1.90, p = 0.057; Std.
## beta = 0.65, 95% CI [-0.02, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.86, 95% CI [-2.50, 8.22], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.31, 95% CI [-0.27, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-8.78, 7.44], t(2068) = -0.16, p = 0.872; Std.
## beta = -0.07, 95% CI [-0.94, 0.80])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-10.13, 5.79], t(2068) = -0.54, p = 0.593; Std.
## beta = -0.23, 95% CI [-1.09, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-34.13, 40.06], t(2068) = 0.16, p = 0.875; Std.
## beta = 0.32, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-25.48, 19.10], t(2068) = -0.28, p = 0.779;
## Std. beta = -0.34, 95% CI [-2.74, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.05, 95% CI [-3.21, 7.32], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.22, 95% CI [-0.34, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-14.68, 27.55], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-5.53, 11.27], t(2068) = 0.67, p = 0.503; Std.
## beta = 0.31, 95% CI [-0.59, 1.21])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.45, 95% CI [-5.85, 6.75], t(2068) = 0.14, p = 0.888; Std.
## beta = 0.05, 95% CI [-0.63, 0.73])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.27, 95% CI [-4.54, 13.08], t(2068) = 0.95, p = 0.342; Std.
## beta = 0.46, 95% CI [-0.49, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-9.08, 1.50], t(2068) = -1.41, p = 0.160; Std.
## beta = -0.41, 95% CI [-0.98, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-8.70, 11.00], t(2068) = 0.23, p = 0.819; Std.
## beta = 0.12, 95% CI [-0.93, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.10, 4.33], t(2068) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.71, 95% CI [-12.09, -1.34], t(2068) = -2.45, p = 0.014;
## Std. beta = -0.72, 95% CI [-1.30, -0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.63, 95% CI [-33.13, 9.86], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-10.29, 8.36], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.10, 95% CI [-1.10, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-3.67, 4.39], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.04, 95% CI [-0.39, 0.47])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-10.65, 2.23], t(2068) = -1.28, p = 0.200; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-4.88, 10.31], t(2068) = 0.70, p = 0.483; Std.
## beta = 0.29, 95% CI [-0.52, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-5.61, 3.85], t(2068) = -0.37, p = 0.715; Std.
## beta = -0.09, 95% CI [-0.60, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.29, 95% CI [3.00, 19.57], t(2068) = 2.67, p = 0.008; Std.
## beta = 1.21, 95% CI [0.32, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-2.63, 8.63], t(2068) = 1.05, p = 0.295; Std.
## beta = 0.32, 95% CI [-0.28, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.60, 95% CI [-8.00, 2.80], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.10, 0.41], t(2068) = -1.74, p = 0.081; Std.
## beta = -0.36, 95% CI [-0.76, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.57, 95% CI [-63.40, -29.74], t(2068) = -5.43, p < .001;
## Std. beta = -5.00, 95% CI [-6.81, -3.20])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-9.28, 8.36], t(2068) = -0.10, p = 0.918; Std.
## beta = -0.05, 95% CI [-1.00, 0.90])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-9.99, 11.74], t(2068) = 0.16, p = 0.874; Std.
## beta = 0.09, 95% CI [-1.07, 1.26])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-9.55, 11.60], t(2068) = 0.19, p = 0.849; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*PM_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14377.7
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2961 -0.4422 -0.0192 0.4449 4.5071
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 232.97 15.263
## time_firstPFT 13.62 3.691 -0.08
## Residual 25.61 5.061
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 36.301299 7.342618 4.944
## time_firstPFT -0.384186 2.886908 -0.133
## PM_5yrPreCensor -0.391492 0.390937 -1.001
## disadv 3.789809 2.889905 1.311
## dich_RaceNon-White -6.972097 2.821250 -2.471
## sexF 3.919343 1.748750 2.241
## age_dx 0.389439 0.091133 4.273
## smokeHxFormer 3.699390 1.730418 2.138
## smokeHxAlways 19.799741 8.514010 2.326
## smokeHxUnknown -2.062748 3.956063 -0.521
## site02R -12.226037 16.211890 -0.754
## site03R 10.344256 11.797071 0.877
## site04R 2.078309 11.288555 0.184
## site05R -13.701509 9.406523 -1.457
## site06R 10.101538 16.156717 0.625
## site07R 10.152517 4.774877 2.126
## site09R 18.717933 11.495625 1.628
## site101 2.390106 3.608865 0.662
## site102 9.965041 6.580226 1.514
## site103 -3.642452 3.522442 -1.034
## site104 -9.690477 6.702739 -1.446
## site105 2.610002 3.542087 0.737
## site106 -7.050138 4.343859 -1.623
## site107 -4.156395 11.613689 -0.358
## site108 2.141980 9.985460 0.215
## site10R 9.654293 17.049724 0.566
## site11R 9.620425 7.194224 1.337
## site12R 5.047449 11.489896 0.439
## site13R 15.949735 8.688445 1.836
## site14R 4.425715 14.695998 0.301
## site15R -35.486631 16.264643 -2.182
## site16R -10.503126 7.426137 -1.414
## site17R 8.881899 16.352465 0.543
## site18R -4.277867 11.533154 -0.371
## site19R 5.285451 7.791177 0.678
## site20R 0.560509 6.867859 0.082
## site21R 2.017511 15.691015 0.129
## site22R -3.763583 5.260237 -0.715
## site23R -14.637057 8.906212 -1.643
## site24R 3.045806 6.364918 0.479
## site25R -0.364395 6.825303 -0.053
## site28R 3.397831 9.466998 0.359
## site29R -8.259798 16.154363 -0.511
## site31R 3.435279 7.448052 0.461
## site32R 7.801663 8.240035 0.947
## site33R -15.531988 8.170677 -1.901
## site34R -1.779969 6.344582 -0.281
## site35R -2.824897 9.666195 -0.292
## site36R -12.830102 7.364274 -1.742
## site37R 14.191388 8.174779 1.736
## site38R 10.755796 5.624761 1.912
## site39R 21.048686 16.462863 1.279
## site40R 25.132185 11.315944 2.221
## site41R -4.735390 9.489138 -0.499
## site42R -2.064655 5.173029 -0.399
## time_firstPFT:PM_5yrPreCensor -0.081271 0.168294 -0.483
## time_firstPFT:disadv -0.006326 1.107340 -0.006
## time_firstPFT:dich_RaceNon-White 0.182797 1.126407 0.162
## time_firstPFT:sexF 0.037611 0.662852 0.057
## time_firstPFT:age_dx -0.060076 0.034693 -1.732
## time_firstPFT:smokeHxFormer 0.522248 0.676210 0.772
## time_firstPFT:smokeHxAlways 0.949833 5.319426 0.179
## time_firstPFT:smokeHxUnknown 1.768998 1.709895 1.035
## time_firstPFT:site02R -14.468078 14.768611 -0.980
## time_firstPFT:site03R 2.688722 5.128547 0.524
## time_firstPFT:site04R -4.863318 5.606073 -0.868
## time_firstPFT:site05R -0.766996 6.267453 -0.122
## time_firstPFT:site07R -3.632407 1.543687 -2.353
## time_firstPFT:site09R -6.431161 4.353543 -1.477
## time_firstPFT:site101 -0.890442 1.292656 -0.689
## time_firstPFT:site102 -3.088241 2.327629 -1.327
## time_firstPFT:site103 1.702458 1.348757 1.262
## time_firstPFT:site104 6.437957 3.649512 1.764
## time_firstPFT:site105 -0.614777 1.283456 -0.479
## time_firstPFT:site106 2.421825 1.737032 1.394
## time_firstPFT:site107 7.372510 6.774206 1.088
## time_firstPFT:site108 5.987704 3.467838 1.727
## time_firstPFT:site11R 3.784791 2.822011 1.341
## time_firstPFT:site12R -0.216637 4.228166 -0.051
## time_firstPFT:site13R -1.608126 4.143186 -0.388
## time_firstPFT:site14R 3.436148 18.953809 0.181
## time_firstPFT:site15R -2.930269 11.414772 -0.257
## time_firstPFT:site16R 1.794997 2.789382 0.644
## time_firstPFT:site18R 6.981806 10.811407 0.646
## time_firstPFT:site19R 4.205901 4.398607 0.956
## time_firstPFT:site20R 1.282542 3.302254 0.388
## time_firstPFT:site21R 4.483105 4.569992 0.981
## time_firstPFT:site22R -2.820358 2.773948 -1.017
## time_firstPFT:site23R 8.907072 24.704663 0.361
## time_firstPFT:site24R -0.283229 2.441526 -0.116
## time_firstPFT:site25R -5.923161 2.837461 -2.087
## time_firstPFT:site28R -10.190465 11.084584 -0.919
## time_firstPFT:site29R -0.282022 4.868167 -0.058
## time_firstPFT:site31R 0.496771 2.155381 0.230
## time_firstPFT:site32R -3.497427 3.363867 -1.040
## time_firstPFT:site33R 3.328090 3.989977 0.834
## time_firstPFT:site34R -0.660803 2.472369 -0.267
## time_firstPFT:site35R 12.237787 4.312085 2.838
## time_firstPFT:site36R 3.361968 2.932881 1.146
## time_firstPFT:site37R -1.854963 2.898975 -0.640
## time_firstPFT:site38R -3.075758 1.956083 -1.572
## time_firstPFT:site39R -47.162723 8.728929 -5.403
## time_firstPFT:site40R 0.649555 4.630209 0.140
## time_firstPFT:site41R 1.709437 5.597226 0.305
## time_firstPFT:site42R 2.023523 5.414971 0.374##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.920
## Unadjusted ICC: 0.696report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## PM_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.24. The model's intercept,
## corresponding to time_firstPFT = 0, is at 36.30 (95% CI [21.90, 50.70], t(2038)
## = 4.94, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## PM_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to
## PM_5yrPreCensor = 0, is at 36.30 (95% CI [21.90, 50.70], t(2038) = 4.94, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to disadv = 0, is at 36.30 (95% CI [21.90,
## 50.70], t(2038) = 4.94, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to dich_Race =
## White, is at 36.30 (95% CI [21.90, 50.70], t(2038) = 4.94, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to sex = M, is at 36.30 (95% CI [21.90,
## 50.70], t(2038) = 4.94, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to age_dx = 0, is at 36.30 (95% CI [21.90,
## 50.70], t(2038) = 4.94, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to smokeHx = Never, is at 36.30 (95% CI
## [21.90, 50.70], t(2038) = 4.94, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to site = Simmons, is at 36.30 (95% CI [21.90,
## 50.70], t(2038) = 4.94, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to cohort =
## CARE-PF, is at 36.30 (95% CI [21.90, 50.70], t(2038) = 4.94, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.38, 95% CI [-6.05, 5.28], t(2038) = -0.13, p = 0.894; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of PM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.39, 95% CI [-1.16, 0.38], t(2038) = -1.00, p = 0.317; Std. beta =
## -0.09, 95% CI [-0.23, 0.06])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.79, 95% CI [-1.88, 9.46], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.50, -1.44], t(2038) = -2.47, p = 0.014; Std. beta =
## -0.39, 95% CI [-0.75, -0.04])
## - The effect of sex [F] is statistically significant and positive (beta = 3.92,
## 95% CI [0.49, 7.35], t(2038) = 2.24, p = 0.025; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.27, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.70, 95% CI [0.31, 7.09], t(2038) = 2.14, p = 0.033; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 19.80, 95% CI [3.10, 36.50], t(2038) = 2.33, p = 0.020; Std. beta =
## 1.25, 95% CI [0.04, 2.47])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.06, 95% CI [-9.82, 5.70], t(2038) = -0.52, p = 0.602; Std. beta =
## 0.04, 95% CI [-0.48, 0.55])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-44.02, 19.57], t(2038) = -0.75, p = 0.451; Std. beta =
## -2.02, 95% CI [-4.79, 0.76])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.34, 95% CI [-12.79, 33.48], t(2038) = 0.88, p = 0.381; Std. beta = 0.85,
## 95% CI [-0.56, 2.26])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-20.06, 24.22], t(2038) = 0.18, p = 0.854; Std. beta = -0.31,
## 95% CI [-1.80, 1.18])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.70, 95% CI [-32.15, 4.75], t(2038) = -1.46, p = 0.145; Std. beta = -0.88,
## 95% CI [-2.25, 0.49])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.10, 95% CI [-21.58, 41.79], t(2038) = 0.63, p = 0.532; Std. beta = 0.60,
## 95% CI [-1.27, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 10.15, 95% CI [0.79, 19.52], t(2038) = 2.13, p = 0.034; Std. beta = 0.27, 95%
## CI [-0.30, 0.85])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 18.72, 95% CI [-3.83, 41.26], t(2038) = 1.63, p = 0.104; Std. beta = 0.53,
## 95% CI [-0.92, 1.97])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.39, 95% CI [-4.69, 9.47], t(2038) = 0.66, p = 0.508; Std. beta = 0.06, 95%
## CI [-0.39, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-2.94, 22.87], t(2038) = 1.51, p = 0.130; Std. beta = 0.31, 95%
## CI [-0.49, 1.11])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.64, 95% CI [-10.55, 3.27], t(2038) = -1.03, p = 0.301; Std. beta = -0.06,
## 95% CI [-0.50, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-22.84, 3.45], t(2038) = -1.45, p = 0.148; Std. beta =
## 4.77e-03, 95% CI [-0.93, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.61, 95% CI [-4.34, 9.56], t(2038) = 0.74, p = 0.461; Std. beta = 0.10, 95%
## CI [-0.34, 0.54])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -7.05, 95% CI [-15.57, 1.47], t(2038) = -1.62, p = 0.105; Std. beta = -0.20,
## 95% CI [-0.73, 0.33])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.16, 95% CI [-26.93, 18.62], t(2038) = -0.36, p = 0.720; Std. beta = 0.41,
## 95% CI [-1.16, 1.99])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-17.44, 21.72], t(2038) = 0.21, p = 0.830; Std. beta = 0.66,
## 95% CI [-0.54, 1.87])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.65, 95% CI [-23.78, 43.09], t(2038) = 0.57, p = 0.571; Std. beta = 0.57,
## 95% CI [-1.40, 2.54])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 9.62, 95% CI [-4.49, 23.73], t(2038) = 1.34, p = 0.181; Std. beta = 0.91, 95%
## CI [2.81e-03, 1.81])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 5.05, 95% CI [-17.49, 27.58], t(2038) = 0.44, p = 0.660; Std. beta = 0.28,
## 95% CI [-1.17, 1.73])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.95, 95% CI [-1.09, 32.99], t(2038) = 1.84, p = 0.067; Std. beta = 0.80,
## 95% CI [-0.27, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-24.40, 33.25], t(2038) = 0.30, p = 0.763; Std. beta = 0.57,
## 95% CI [-2.05, 3.18])
## - The effect of site [15R] is statistically significant and negative (beta =
## -35.49, 95% CI [-67.38, -3.59], t(2038) = -2.18, p = 0.029; Std. beta = -2.36,
## 95% CI [-4.71, 9.16e-04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.50, 95% CI [-25.07, 4.06], t(2038) = -1.41, p = 0.157; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.88, 95% CI [-23.19, 40.95], t(2038) = 0.54, p = 0.587; Std. beta = 0.52,
## 95% CI [-1.37, 2.42])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.28, 95% CI [-26.90, 18.34], t(2038) = -0.37, p = 0.711; Std. beta = 0.37,
## 95% CI [-1.73, 2.48])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-9.99, 20.56], t(2038) = 0.68, p = 0.498; Std. beta = 0.69, 95%
## CI [-0.39, 1.76])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-12.91, 14.03], t(2038) = 0.08, p = 0.935; Std. beta = 0.15,
## 95% CI [-0.75, 1.04])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-28.75, 32.79], t(2038) = 0.13, p = 0.898; Std. beta = 0.52,
## 95% CI [-1.34, 2.38])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-14.08, 6.55], t(2038) = -0.72, p = 0.474; Std. beta = -0.47,
## 95% CI [-1.17, 0.22])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-32.10, 2.83], t(2038) = -1.64, p = 0.100; Std. beta = -0.07,
## 95% CI [-4.13, 3.99])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-9.44, 15.53], t(2038) = 0.48, p = 0.632; Std. beta = 0.15, 95%
## CI [-0.63, 0.94])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-13.75, 13.02], t(2038) = -0.05, p = 0.957; Std. beta = -0.55,
## 95% CI [-1.40, 0.30])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.40, 95% CI [-15.17, 21.96], t(2038) = 0.36, p = 0.720; Std. beta = -0.71,
## 95% CI [-2.80, 1.37])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -8.26, 95% CI [-39.94, 23.42], t(2038) = -0.51, p = 0.609; Std. beta = -0.51,
## 95% CI [-2.40, 1.38])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-11.17, 18.04], t(2038) = 0.46, p = 0.645; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-8.36, 23.96], t(2038) = 0.95, p = 0.344; Std. beta = 0.15, 95%
## CI [-0.89, 1.18])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.53, 95% CI [-31.56, 0.49], t(2038) = -1.90, p = 0.057; Std. beta = -0.62,
## 95% CI [-1.72, 0.48])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.78, 95% CI [-14.22, 10.66], t(2038) = -0.28, p = 0.779; Std. beta = -0.16,
## 95% CI [-0.95, 0.62])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.82, 95% CI [-21.78, 16.13], t(2038) = -0.29, p = 0.770; Std. beta = 0.93,
## 95% CI [-0.29, 2.15])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.83, 95% CI [-27.27, 1.61], t(2038) = -1.74, p = 0.082; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 14.19, 95% CI [-1.84, 30.22], t(2038) = 1.74, p = 0.083; Std. beta = 0.67,
## 95% CI [-0.32, 1.67])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.76, 95% CI [-0.28, 21.79], t(2038) = 1.91, p = 0.056; Std. beta = 0.36,
## 95% CI [-0.33, 1.04])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 21.05, 95% CI [-11.24, 53.33], t(2038) = 1.28, p = 0.201; Std. beta = -2.98,
## 95% CI [-5.15, -0.81])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.13, 95% CI [2.94, 47.32], t(2038) = 2.22, p = 0.026; Std. beta = 1.54, 95%
## CI [0.08, 3.00])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-23.34, 13.87], t(2038) = -0.50, p = 0.618; Std. beta = -0.13,
## 95% CI [-1.44, 1.19])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-12.21, 8.08], t(2038) = -0.40, p = 0.690; Std. beta = 0.06,
## 95% CI [-0.91, 1.03])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.08, 95% CI [-0.41, 0.25], t(2038) =
## -0.48, p = 0.629; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -6.33e-03, 95% CI [-2.18, 2.17], t(2038) = -5.71e-03, p =
## 0.995; Std. beta = -1.94e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.18, 95% CI [-2.03, 2.39], t(2038) =
## 0.16, p = 0.871; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-1.26, 1.34], t(2038) = 0.06, p = 0.955; Std.
## beta = 4.05e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.96e-03], t(2038) = -1.73, p = 0.083;
## Std. beta = -0.06, 95% CI [-0.13, 7.90e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.77, p = 0.440; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 0.95, 95% CI [-9.48, 11.38], t(2038) =
## 0.18, p = 0.858; Std. beta = 0.10, 95% CI [-1.02, 1.23])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.77, 95% CI [-1.58, 5.12], t(2038) =
## 1.03, p = 0.301; Std. beta = 0.19, 95% CI [-0.17, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.47, 95% CI [-43.43, 14.50], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-7.37, 12.75], t(2038) = 0.52, p = 0.600; Std.
## beta = 0.29, 95% CI [-0.79, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-15.86, 6.13], t(2038) = -0.87, p = 0.386; Std.
## beta = -0.52, 95% CI [-1.71, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-13.06, 11.52], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.63, 95% CI [-6.66, -0.61], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.39, 95% CI [-0.72, -0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-14.97, 2.11], t(2038) = -1.48, p = 0.140; Std.
## beta = -0.69, 95% CI [-1.61, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-3.43, 1.64], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.10, 95% CI [-0.37, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.09, 95% CI [-7.65, 1.48], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-0.94, 4.35], t(2038) = 1.26, p = 0.207; Std.
## beta = 0.18, 95% CI [-0.10, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.44, 95% CI [-0.72, 13.60], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.69, 95% CI [-0.08, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-3.13, 1.90], t(2038) = -0.48, p = 0.632; Std.
## beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.98, 5.83], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.91, 20.66], t(2038) = 1.09, p = 0.277; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.99, 95% CI [-0.81, 12.79], t(2038) = 1.73, p = 0.084; Std.
## beta = 0.64, 95% CI [-0.09, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.78, 95% CI [-1.75, 9.32], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.22, 95% CI [-8.51, 8.08], t(2038) = -0.05, p = 0.959; Std.
## beta = -0.02, 95% CI [-0.92, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-9.73, 6.52], t(2038) = -0.39, p = 0.698; Std.
## beta = -0.17, 95% CI [-1.05, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-33.73, 40.61], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.32, 19.46], t(2038) = -0.26, p = 0.797;
## Std. beta = -0.32, 95% CI [-2.73, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-3.68, 7.27], t(2038) = 0.64, p = 0.520; Std.
## beta = 0.19, 95% CI [-0.40, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.98, 95% CI [-14.22, 28.18], t(2038) = 0.65, p = 0.518; Std.
## beta = 0.75, 95% CI [-1.53, 3.04])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.21, 95% CI [-4.42, 12.83], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-5.19, 7.76], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.48, 95% CI [-4.48, 13.45], t(2038) = 0.98, p = 0.327; Std.
## beta = 0.48, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.82, 95% CI [-8.26, 2.62], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.30, 95% CI [-0.89, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.91, 95% CI [-39.54, 57.36], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.96, 95% CI [-4.26, 6.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.07, 4.50], t(2038) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.92, 95% CI [-11.49, -0.36], t(2038) = -2.09, p = 0.037;
## Std. beta = -0.64, 95% CI [-1.24, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.19, 95% CI [-31.93, 11.55], t(2038) = -0.92, p = 0.358;
## Std. beta = -1.10, 95% CI [-3.44, 1.24])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-9.83, 9.27], t(2038) = -0.06, p = 0.954; Std.
## beta = -0.03, 95% CI [-1.06, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.73, 4.72], t(2038) = 0.23, p = 0.818; Std.
## beta = 0.05, 95% CI [-0.40, 0.51])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-10.09, 3.10], t(2038) = -1.04, p = 0.299; Std.
## beta = -0.38, 95% CI [-1.09, 0.33])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-4.50, 11.15], t(2038) = 0.83, p = 0.404; Std.
## beta = 0.36, 95% CI [-0.48, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.24, 95% CI [3.78, 20.69], t(2038) = 2.84, p = 0.005; Std.
## beta = 1.32, 95% CI [0.41, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-2.39, 9.11], t(2038) = 1.15, p = 0.252; Std.
## beta = 0.36, 95% CI [-0.26, 0.98])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.85, 95% CI [-7.54, 3.83], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.20, 95% CI [-0.81, 0.41])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-6.91, 0.76], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.33, 95% CI [-0.74, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.16, 95% CI [-64.28, -30.04], t(2038) = -5.40, p < .001;
## Std. beta = -5.08, 95% CI [-6.92, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-8.43, 9.73], t(2038) = 0.14, p = 0.888; Std.
## beta = 0.07, 95% CI [-0.91, 1.05])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-9.27, 12.69], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-1.00, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.60, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*SO4_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14559
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3235 -0.4418 -0.0204 0.4463 4.5134
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 252.05 15.876
## time_firstPFT 13.00 3.605 -0.12
## Residual 25.58 5.057
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 69.46689 3.66267 18.966
## time_firstPFT -3.84856 1.26949 -3.032
## SO4_5yrPreCensor -2.72269 0.93993 -2.897
## site02R -15.81313 16.90826 -0.935
## site03R 5.82874 12.27196 0.475
## site04R -2.98950 11.85047 -0.252
## site05R -16.16341 9.78252 -1.652
## site06R 15.10672 11.97595 1.261
## site07R 6.30402 5.18730 1.215
## site09R 14.67929 11.97428 1.226
## site101 -3.58647 3.95939 -0.906
## site102 2.33900 6.96854 0.336
## site103 -9.56672 4.02406 -2.377
## site104 -14.38375 7.09526 -2.027
## site105 -2.72585 4.02072 -0.678
## site106 -9.85317 4.64355 -2.122
## site107 -12.22083 12.08010 -1.012
## site108 -8.47956 9.96865 -0.851
## site10R 6.84372 17.44890 0.392
## site11R 8.44843 7.62080 1.109
## site12R 3.92087 11.99225 0.327
## site13R 9.93747 9.03363 1.100
## site14R 0.52223 15.06520 0.035
## site15R -33.81928 16.84639 -2.008
## site16R -21.55821 7.76241 -2.777
## site17R 0.03175 16.83247 0.002
## site18R -5.34736 12.01185 -0.445
## site19R -0.07655 8.09053 -0.009
## site20R -2.65340 7.22236 -0.367
## site21R -1.56916 16.37507 -0.096
## site22R -4.64332 5.60248 -0.829
## site23R -16.09952 7.78302 -2.069
## site24R -1.34325 6.82375 -0.197
## site25R -6.32997 7.41973 -0.853
## site28R -4.16764 9.84591 -0.423
## site29R -11.02348 16.73313 -0.659
## site31R -2.44886 7.71711 -0.317
## site32R 3.81516 8.80430 0.433
## site33R -21.00240 8.50055 -2.471
## site34R -4.00916 6.70437 -0.598
## site35R -1.73096 10.02793 -0.173
## site36R -18.34509 7.72881 -2.374
## site37R 6.41551 8.54655 0.751
## site38R 6.21231 6.00121 1.035
## site39R 9.88904 16.80135 0.589
## site40R 21.27441 11.94002 1.782
## site41R -7.71699 9.89441 -0.780
## site42R -5.99098 5.51625 -1.086
## time_firstPFT:SO4_5yrPreCensor -0.08796 0.33720 -0.261
## time_firstPFT:site02R -15.35748 14.74676 -1.041
## time_firstPFT:site03R 1.33638 5.09582 0.262
## time_firstPFT:site04R -5.28181 5.55322 -0.951
## time_firstPFT:site05R -1.02817 6.23314 -0.165
## time_firstPFT:site06R -3.21351 4.81588 -0.667
## time_firstPFT:site07R -4.10793 1.57092 -2.615
## time_firstPFT:site09R -6.61087 4.29788 -1.538
## time_firstPFT:site101 -0.93926 1.31386 -0.715
## time_firstPFT:site102 -2.84255 2.31480 -1.228
## time_firstPFT:site103 1.66283 1.38874 1.197
## time_firstPFT:site104 6.12741 3.59003 1.707
## time_firstPFT:site105 -0.56725 1.34949 -0.420
## time_firstPFT:site106 1.85426 1.72582 1.074
## time_firstPFT:site107 7.37538 6.74085 1.094
## time_firstPFT:site108 6.28288 3.20575 1.960
## time_firstPFT:site11R 2.85496 2.79205 1.023
## time_firstPFT:site12R -0.56919 4.17033 -0.136
## time_firstPFT:site13R -2.10663 4.08029 -0.516
## time_firstPFT:site14R 3.10228 18.92192 0.164
## time_firstPFT:site15R -3.12766 11.37581 -0.275
## time_firstPFT:site16R 2.12638 2.73959 0.776
## time_firstPFT:site18R 6.45526 10.78022 0.599
## time_firstPFT:site19R 3.06902 4.29270 0.715
## time_firstPFT:site20R 0.57236 3.23327 0.177
## time_firstPFT:site21R 4.23014 4.52870 0.934
## time_firstPFT:site22R -3.73166 2.74644 -1.359
## time_firstPFT:site23R 1.24866 5.02856 0.248
## time_firstPFT:site24R -0.27593 2.46327 -0.112
## time_firstPFT:site25R -6.71682 2.86510 -2.344
## time_firstPFT:site28R -11.63525 10.96688 -1.061
## time_firstPFT:site29R -0.82957 4.77034 -0.174
## time_firstPFT:site31R 0.50424 2.07928 0.243
## time_firstPFT:site32R -4.28212 3.39315 -1.262
## time_firstPFT:site33R 2.83459 3.87885 0.731
## time_firstPFT:site34R -0.76810 2.45045 -0.313
## time_firstPFT:site35R 11.50934 4.21493 2.731
## time_firstPFT:site36R 3.07736 2.90447 1.060
## time_firstPFT:site37R -2.58639 2.82148 -0.917
## time_firstPFT:site38R -3.25023 1.96590 -1.653
## time_firstPFT:site39R -46.40257 8.59505 -5.399
## time_firstPFT:site40R -0.30087 4.52775 -0.066
## time_firstPFT:site41R 0.93642 5.57173 0.168
## time_firstPFT:site42R 1.06962 5.41153 0.198##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.923
## Unadjusted ICC: 0.733report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SO4_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.21. The model's
## intercept, corresponding to time_firstPFT = 0, is at 69.47 (95% CI [62.28,
## 76.65], t(2068) = 18.97, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.85, 95% CI [-6.34, -1.36], t(2068) = -3.03, p = 0.002; Std. beta = -0.43,
## 95% CI [-0.58, -0.29])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.72, 95% CI [-4.57, -0.88], t(2068) = -2.90, p = 0.004; Std. beta =
## -0.26, 95% CI [-0.43, -0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -15.81, 95% CI [-48.97, 17.35], t(2068) = -0.94, p = 0.350; Std. beta =
## -2.30, 95% CI [-5.11, 0.50])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-18.24, 29.90], t(2068) = 0.47, p = 0.635; Std. beta = 0.46,
## 95% CI [-0.98, 1.91])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-26.23, 20.25], t(2068) = -0.25, p = 0.801; Std. beta = -0.65,
## 95% CI [-2.17, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.16, 95% CI [-35.35, 3.02], t(2068) = -1.65, p = 0.099; Std. beta = -1.05,
## 95% CI [-2.43, 0.34])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 15.11, 95% CI [-8.38, 38.59], t(2068) = 1.26, p = 0.207; Std. beta = 0.60,
## 95% CI [-0.90, 2.11])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.30, 95% CI [-3.87, 16.48], t(2068) = 1.22, p = 0.224; Std. beta = 5.64e-03,
## 95% CI [-0.61, 0.62])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.68, 95% CI [-8.80, 38.16], t(2068) = 1.23, p = 0.220; Std. beta = 0.28,
## 95% CI [-1.20, 1.75])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-11.35, 4.18], t(2068) = -0.91, p = 0.365; Std. beta = -0.30,
## 95% CI [-0.77, 0.18])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.33, 16.01], t(2068) = 0.34, p = 0.737; Std. beta = -0.12,
## 95% CI [-0.95, 0.72])
## - The effect of site [103] is statistically significant and negative (beta =
## -9.57, 95% CI [-17.46, -1.68], t(2068) = -2.38, p = 0.018; Std. beta = -0.42,
## 95% CI [-0.90, 0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.38, 95% CI [-28.30, -0.47], t(2068) = -2.03, p = 0.043; Std. beta = -0.30,
## 95% CI [-1.25, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.73, 95% CI [-10.61, 5.16], t(2068) = -0.68, p = 0.498; Std. beta = -0.21,
## 95% CI [-0.70, 0.27])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.85, 95% CI [-18.96, -0.75], t(2068) = -2.12, p = 0.034; Std. beta = -0.42,
## 95% CI [-0.97, 0.14])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-35.91, 11.47], t(2068) = -1.01, p = 0.312; Std. beta =
## -0.06, 95% CI [-1.66, 1.54])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.48, 95% CI [-28.03, 11.07], t(2068) = -0.85, p = 0.395; Std. beta = 0.06,
## 95% CI [-1.12, 1.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.84, 95% CI [-27.38, 41.06], t(2068) = 0.39, p = 0.695; Std. beta = 0.40,
## 95% CI [-1.61, 2.42])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.45, 95% CI [-6.50, 23.39], t(2068) = 1.11, p = 0.268; Std. beta = 0.75, 95%
## CI [-0.18, 1.69])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-19.60, 27.44], t(2068) = 0.33, p = 0.744; Std. beta = 0.18,
## 95% CI [-1.30, 1.66])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 9.94, 95% CI [-7.78, 27.65], t(2068) = 1.10, p = 0.271; Std. beta = 0.40, 95%
## CI [-0.69, 1.48])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-29.02, 30.07], t(2068) = 0.03, p = 0.972; Std. beta = 0.31,
## 95% CI [-2.31, 2.93])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.82, 95% CI [-66.86, -0.78], t(2068) = -2.01, p = 0.045; Std. beta = -2.27,
## 95% CI [-4.66, 0.11])
## - The effect of site [16R] is statistically significant and negative (beta =
## -21.56, 95% CI [-36.78, -6.34], t(2068) = -2.78, p = 0.006; Std. beta = -1.08,
## 95% CI [-2.04, -0.13])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-32.98, 33.04], t(2068) = 1.89e-03, p = 0.998; Std. beta =
## 1.87e-03, 95% CI [-1.95, 1.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.35, 95% CI [-28.90, 18.21], t(2068) = -0.45, p = 0.656; Std. beta = 0.26,
## 95% CI [-1.86, 2.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-15.94, 15.79], t(2068) = -9.46e-03, p = 0.992; Std. beta =
## 0.27, 95% CI [-0.81, 1.35])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.65, 95% CI [-16.82, 11.51], t(2068) = -0.37, p = 0.713; Std. beta = -0.11,
## 95% CI [-1.02, 0.81])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-33.68, 30.54], t(2068) = -0.10, p = 0.924; Std. beta = 0.28,
## 95% CI [-1.63, 2.19])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.64, 95% CI [-15.63, 6.34], t(2068) = -0.83, p = 0.407; Std. beta = -0.61,
## 95% CI [-1.33, 0.11])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.10, 95% CI [-31.36, -0.84], t(2068) = -2.07, p = 0.039; Std. beta = -0.84,
## 95% CI [-1.99, 0.31])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.34, 95% CI [-14.73, 12.04], t(2068) = -0.20, p = 0.844; Std. beta = -0.10,
## 95% CI [-0.93, 0.72])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-20.88, 8.22], t(2068) = -0.85, p = 0.394; Std. beta = -0.97,
## 95% CI [-1.87, -0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-23.48, 15.14], t(2068) = -0.42, p = 0.672; Std. beta = -1.28,
## 95% CI [-3.36, 0.79])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-43.84, 21.79], t(2068) = -0.66, p = 0.510; Std. beta =
## -0.72, 95% CI [-2.65, 1.20])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-17.58, 12.69], t(2068) = -0.32, p = 0.751; Std. beta = -0.10,
## 95% CI [-1.00, 0.80])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-13.45, 21.08], t(2068) = 0.43, p = 0.665; Std. beta = -0.16,
## 95% CI [-1.24, 0.92])
## - The effect of site [33R] is statistically significant and negative (beta =
## -21.00, 95% CI [-37.67, -4.33], t(2068) = -2.47, p = 0.014; Std. beta = -0.99,
## 95% CI [-2.10, 0.12])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.01, 95% CI [-17.16, 9.14], t(2068) = -0.60, p = 0.550; Std. beta = -0.30,
## 95% CI [-1.12, 0.51])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-21.40, 17.93], t(2068) = -0.17, p = 0.863; Std. beta = 0.92,
## 95% CI [-0.31, 2.16])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.50, -3.19], t(2068) = -2.37, p = 0.018; Std. beta = -0.81,
## 95% CI [-1.77, 0.15])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-10.35, 23.18], t(2068) = 0.75, p = 0.453; Std. beta = 0.15,
## 95% CI [-0.87, 1.17])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-5.56, 17.98], t(2068) = 1.04, p = 0.301; Std. beta = 0.08, 95%
## CI [-0.64, 0.79])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.89, 95% CI [-23.06, 42.84], t(2068) = 0.59, p = 0.556; Std. beta = -3.55,
## 95% CI [-5.72, -1.38])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.27, 95% CI [-2.14, 44.69], t(2068) = 1.78, p = 0.075; Std. beta = 1.23,
## 95% CI [-0.27, 2.73])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-27.12, 11.69], t(2068) = -0.78, p = 0.436; Std. beta = -0.37,
## 95% CI [-1.71, 0.96])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.81, 4.83], t(2068) = -1.09, p = 0.278; Std. beta = -0.26,
## 95% CI [-1.24, 0.73])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.09, 95% CI [-0.75, 0.57], t(2068) =
## -0.26, p = 0.794; Std. beta = -0.01, 95% CI [-0.12, 0.09])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.36, 95% CI [-44.28, 13.56], t(2068) = -1.04, p = 0.298;
## Std. beta = -1.65, 95% CI [-4.76, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.66, 11.33], t(2068) = 0.26, p = 0.793; Std.
## beta = 0.14, 95% CI [-0.93, 1.22])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.28, 95% CI [-16.17, 5.61], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.57, 95% CI [-1.74, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-13.25, 11.20], t(2068) = -0.16, p = 0.869;
## Std. beta = -0.11, 95% CI [-1.42, 1.20])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.21, 95% CI [-12.66, 6.23], t(2068) = -0.67, p = 0.505; Std.
## beta = -0.35, 95% CI [-1.36, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.11, 95% CI [-7.19, -1.03], t(2068) = -2.61, p = 0.009; Std.
## beta = -0.44, 95% CI [-0.77, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-15.04, 1.82], t(2068) = -1.54, p = 0.124; Std.
## beta = -0.71, 95% CI [-1.62, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.52, 1.64], t(2068) = -0.71, p = 0.475; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-7.38, 1.70], t(2068) = -1.23, p = 0.220; Std.
## beta = -0.31, 95% CI [-0.79, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-1.06, 4.39], t(2068) = 1.20, p = 0.231; Std.
## beta = 0.18, 95% CI [-0.11, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.13, 95% CI [-0.91, 13.17], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.66, 95% CI [-0.10, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-3.21, 2.08], t(2068) = -0.42, p = 0.674; Std.
## beta = -0.06, 95% CI [-0.35, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.53, 5.24], t(2068) = 1.07, p = 0.283; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.38, 95% CI [-5.84, 20.59], t(2068) = 1.09, p = 0.274; Std.
## beta = 0.79, 95% CI [-0.63, 2.21])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-3.96e-03, 12.57], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.68, 95% CI [-4.28e-04, 1.35])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-2.62, 8.33], t(2068) = 1.02, p = 0.307; Std.
## beta = 0.31, 95% CI [-0.28, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.75, 7.61], t(2068) = -0.14, p = 0.891; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-10.11, 5.90], t(2068) = -0.52, p = 0.606; Std.
## beta = -0.23, 95% CI [-1.09, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-34.01, 40.21], t(2068) = 0.16, p = 0.870; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-25.44, 19.18], t(2068) = -0.27, p = 0.783;
## Std. beta = -0.34, 95% CI [-2.73, 2.06])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-3.25, 7.50], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.23, 95% CI [-0.35, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.46, 95% CI [-14.69, 27.60], t(2068) = 0.60, p = 0.549; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.35, 11.49], t(2068) = 0.71, p = 0.475; Std.
## beta = 0.33, 95% CI [-0.57, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-5.77, 6.91], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.06, 95% CI [-0.62, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.65, 13.11], t(2068) = 0.93, p = 0.350; Std.
## beta = 0.45, 95% CI [-0.50, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.73, 95% CI [-9.12, 1.65], t(2068) = -1.36, p = 0.174; Std.
## beta = -0.40, 95% CI [-0.98, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.61, 11.11], t(2068) = 0.25, p = 0.804; Std.
## beta = 0.13, 95% CI [-0.93, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.11, 4.55], t(2068) = -0.11, p = 0.911; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.72, 95% CI [-12.34, -1.10], t(2068) = -2.34, p = 0.019;
## Std. beta = -0.72, 95% CI [-1.33, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.64, 95% CI [-33.14, 9.87], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-10.18, 8.53], t(2068) = -0.17, p = 0.862; Std.
## beta = -0.09, 95% CI [-1.09, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.57, 4.58], t(2068) = 0.24, p = 0.808; Std.
## beta = 0.05, 95% CI [-0.38, 0.49])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-10.94, 2.37], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.46, 95% CI [-1.17, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.77, 10.44], t(2068) = 0.73, p = 0.465; Std.
## beta = 0.30, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-5.57, 4.04], t(2068) = -0.31, p = 0.754; Std.
## beta = -0.08, 95% CI [-0.60, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.51, 95% CI [3.24, 19.78], t(2068) = 2.73, p = 0.006; Std.
## beta = 1.24, 95% CI [0.35, 2.12])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-2.62, 8.77], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.33, 95% CI [-0.28, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.12, 2.95], t(2068) = -0.92, p = 0.359; Std.
## beta = -0.28, 95% CI [-0.87, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.25, 95% CI [-7.11, 0.61], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.35, 95% CI [-0.76, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.40, 95% CI [-63.26, -29.55], t(2068) = -5.40, p < .001;
## Std. beta = -4.99, 95% CI [-6.80, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.18, 8.58], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-0.99, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.99, 11.86], t(2068) = 0.17, p = 0.867; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.54, 11.68], t(2068) = 0.20, p = 0.843; Std.
## beta = 0.11, 95% CI [-1.03, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SO4_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to SO4_5yrPreCensor = 0, is at 69.47 (95% CI [62.28, 76.65],
## t(2068) = 18.97, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.85, 95% CI [-6.34, -1.36], t(2068) = -3.03, p = 0.002; Std. beta = -0.43,
## 95% CI [-0.58, -0.29])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.72, 95% CI [-4.57, -0.88], t(2068) = -2.90, p = 0.004; Std. beta =
## -0.26, 95% CI [-0.43, -0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -15.81, 95% CI [-48.97, 17.35], t(2068) = -0.94, p = 0.350; Std. beta =
## -2.30, 95% CI [-5.11, 0.50])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-18.24, 29.90], t(2068) = 0.47, p = 0.635; Std. beta = 0.46,
## 95% CI [-0.98, 1.91])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-26.23, 20.25], t(2068) = -0.25, p = 0.801; Std. beta = -0.65,
## 95% CI [-2.17, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.16, 95% CI [-35.35, 3.02], t(2068) = -1.65, p = 0.099; Std. beta = -1.05,
## 95% CI [-2.43, 0.34])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 15.11, 95% CI [-8.38, 38.59], t(2068) = 1.26, p = 0.207; Std. beta = 0.60,
## 95% CI [-0.90, 2.11])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.30, 95% CI [-3.87, 16.48], t(2068) = 1.22, p = 0.224; Std. beta = 5.64e-03,
## 95% CI [-0.61, 0.62])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.68, 95% CI [-8.80, 38.16], t(2068) = 1.23, p = 0.220; Std. beta = 0.28,
## 95% CI [-1.20, 1.75])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-11.35, 4.18], t(2068) = -0.91, p = 0.365; Std. beta = -0.30,
## 95% CI [-0.77, 0.18])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.33, 16.01], t(2068) = 0.34, p = 0.737; Std. beta = -0.12,
## 95% CI [-0.95, 0.72])
## - The effect of site [103] is statistically significant and negative (beta =
## -9.57, 95% CI [-17.46, -1.68], t(2068) = -2.38, p = 0.018; Std. beta = -0.42,
## 95% CI [-0.90, 0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.38, 95% CI [-28.30, -0.47], t(2068) = -2.03, p = 0.043; Std. beta = -0.30,
## 95% CI [-1.25, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.73, 95% CI [-10.61, 5.16], t(2068) = -0.68, p = 0.498; Std. beta = -0.21,
## 95% CI [-0.70, 0.27])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.85, 95% CI [-18.96, -0.75], t(2068) = -2.12, p = 0.034; Std. beta = -0.42,
## 95% CI [-0.97, 0.14])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-35.91, 11.47], t(2068) = -1.01, p = 0.312; Std. beta =
## -0.06, 95% CI [-1.66, 1.54])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.48, 95% CI [-28.03, 11.07], t(2068) = -0.85, p = 0.395; Std. beta = 0.06,
## 95% CI [-1.12, 1.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.84, 95% CI [-27.38, 41.06], t(2068) = 0.39, p = 0.695; Std. beta = 0.40,
## 95% CI [-1.61, 2.42])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.45, 95% CI [-6.50, 23.39], t(2068) = 1.11, p = 0.268; Std. beta = 0.75, 95%
## CI [-0.18, 1.69])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-19.60, 27.44], t(2068) = 0.33, p = 0.744; Std. beta = 0.18,
## 95% CI [-1.30, 1.66])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 9.94, 95% CI [-7.78, 27.65], t(2068) = 1.10, p = 0.271; Std. beta = 0.40, 95%
## CI [-0.69, 1.48])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-29.02, 30.07], t(2068) = 0.03, p = 0.972; Std. beta = 0.31,
## 95% CI [-2.31, 2.93])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.82, 95% CI [-66.86, -0.78], t(2068) = -2.01, p = 0.045; Std. beta = -2.27,
## 95% CI [-4.66, 0.11])
## - The effect of site [16R] is statistically significant and negative (beta =
## -21.56, 95% CI [-36.78, -6.34], t(2068) = -2.78, p = 0.006; Std. beta = -1.08,
## 95% CI [-2.04, -0.13])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-32.98, 33.04], t(2068) = 1.89e-03, p = 0.998; Std. beta =
## 1.87e-03, 95% CI [-1.95, 1.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.35, 95% CI [-28.90, 18.21], t(2068) = -0.45, p = 0.656; Std. beta = 0.26,
## 95% CI [-1.86, 2.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-15.94, 15.79], t(2068) = -9.46e-03, p = 0.992; Std. beta =
## 0.27, 95% CI [-0.81, 1.35])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.65, 95% CI [-16.82, 11.51], t(2068) = -0.37, p = 0.713; Std. beta = -0.11,
## 95% CI [-1.02, 0.81])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-33.68, 30.54], t(2068) = -0.10, p = 0.924; Std. beta = 0.28,
## 95% CI [-1.63, 2.19])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.64, 95% CI [-15.63, 6.34], t(2068) = -0.83, p = 0.407; Std. beta = -0.61,
## 95% CI [-1.33, 0.11])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.10, 95% CI [-31.36, -0.84], t(2068) = -2.07, p = 0.039; Std. beta = -0.84,
## 95% CI [-1.99, 0.31])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.34, 95% CI [-14.73, 12.04], t(2068) = -0.20, p = 0.844; Std. beta = -0.10,
## 95% CI [-0.93, 0.72])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-20.88, 8.22], t(2068) = -0.85, p = 0.394; Std. beta = -0.97,
## 95% CI [-1.87, -0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-23.48, 15.14], t(2068) = -0.42, p = 0.672; Std. beta = -1.28,
## 95% CI [-3.36, 0.79])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-43.84, 21.79], t(2068) = -0.66, p = 0.510; Std. beta =
## -0.72, 95% CI [-2.65, 1.20])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-17.58, 12.69], t(2068) = -0.32, p = 0.751; Std. beta = -0.10,
## 95% CI [-1.00, 0.80])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-13.45, 21.08], t(2068) = 0.43, p = 0.665; Std. beta = -0.16,
## 95% CI [-1.24, 0.92])
## - The effect of site [33R] is statistically significant and negative (beta =
## -21.00, 95% CI [-37.67, -4.33], t(2068) = -2.47, p = 0.014; Std. beta = -0.99,
## 95% CI [-2.10, 0.12])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.01, 95% CI [-17.16, 9.14], t(2068) = -0.60, p = 0.550; Std. beta = -0.30,
## 95% CI [-1.12, 0.51])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-21.40, 17.93], t(2068) = -0.17, p = 0.863; Std. beta = 0.92,
## 95% CI [-0.31, 2.16])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.50, -3.19], t(2068) = -2.37, p = 0.018; Std. beta = -0.81,
## 95% CI [-1.77, 0.15])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-10.35, 23.18], t(2068) = 0.75, p = 0.453; Std. beta = 0.15,
## 95% CI [-0.87, 1.17])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-5.56, 17.98], t(2068) = 1.04, p = 0.301; Std. beta = 0.08, 95%
## CI [-0.64, 0.79])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.89, 95% CI [-23.06, 42.84], t(2068) = 0.59, p = 0.556; Std. beta = -3.55,
## 95% CI [-5.72, -1.38])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.27, 95% CI [-2.14, 44.69], t(2068) = 1.78, p = 0.075; Std. beta = 1.23,
## 95% CI [-0.27, 2.73])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-27.12, 11.69], t(2068) = -0.78, p = 0.436; Std. beta = -0.37,
## 95% CI [-1.71, 0.96])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.81, 4.83], t(2068) = -1.09, p = 0.278; Std. beta = -0.26,
## 95% CI [-1.24, 0.73])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.09, 95% CI [-0.75, 0.57], t(2068) =
## -0.26, p = 0.794; Std. beta = -0.01, 95% CI [-0.12, 0.09])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.36, 95% CI [-44.28, 13.56], t(2068) = -1.04, p = 0.298;
## Std. beta = -1.65, 95% CI [-4.76, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.66, 11.33], t(2068) = 0.26, p = 0.793; Std.
## beta = 0.14, 95% CI [-0.93, 1.22])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.28, 95% CI [-16.17, 5.61], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.57, 95% CI [-1.74, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-13.25, 11.20], t(2068) = -0.16, p = 0.869;
## Std. beta = -0.11, 95% CI [-1.42, 1.20])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.21, 95% CI [-12.66, 6.23], t(2068) = -0.67, p = 0.505; Std.
## beta = -0.35, 95% CI [-1.36, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.11, 95% CI [-7.19, -1.03], t(2068) = -2.61, p = 0.009; Std.
## beta = -0.44, 95% CI [-0.77, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-15.04, 1.82], t(2068) = -1.54, p = 0.124; Std.
## beta = -0.71, 95% CI [-1.62, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.52, 1.64], t(2068) = -0.71, p = 0.475; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-7.38, 1.70], t(2068) = -1.23, p = 0.220; Std.
## beta = -0.31, 95% CI [-0.79, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-1.06, 4.39], t(2068) = 1.20, p = 0.231; Std.
## beta = 0.18, 95% CI [-0.11, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.13, 95% CI [-0.91, 13.17], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.66, 95% CI [-0.10, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-3.21, 2.08], t(2068) = -0.42, p = 0.674; Std.
## beta = -0.06, 95% CI [-0.35, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.53, 5.24], t(2068) = 1.07, p = 0.283; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.38, 95% CI [-5.84, 20.59], t(2068) = 1.09, p = 0.274; Std.
## beta = 0.79, 95% CI [-0.63, 2.21])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-3.96e-03, 12.57], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.68, 95% CI [-4.28e-04, 1.35])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-2.62, 8.33], t(2068) = 1.02, p = 0.307; Std.
## beta = 0.31, 95% CI [-0.28, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.75, 7.61], t(2068) = -0.14, p = 0.891; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-10.11, 5.90], t(2068) = -0.52, p = 0.606; Std.
## beta = -0.23, 95% CI [-1.09, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-34.01, 40.21], t(2068) = 0.16, p = 0.870; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-25.44, 19.18], t(2068) = -0.27, p = 0.783;
## Std. beta = -0.34, 95% CI [-2.73, 2.06])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-3.25, 7.50], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.23, 95% CI [-0.35, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.46, 95% CI [-14.69, 27.60], t(2068) = 0.60, p = 0.549; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.35, 11.49], t(2068) = 0.71, p = 0.475; Std.
## beta = 0.33, 95% CI [-0.57, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-5.77, 6.91], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.06, 95% CI [-0.62, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.65, 13.11], t(2068) = 0.93, p = 0.350; Std.
## beta = 0.45, 95% CI [-0.50, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.73, 95% CI [-9.12, 1.65], t(2068) = -1.36, p = 0.174; Std.
## beta = -0.40, 95% CI [-0.98, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.61, 11.11], t(2068) = 0.25, p = 0.804; Std.
## beta = 0.13, 95% CI [-0.93, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.11, 4.55], t(2068) = -0.11, p = 0.911; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.72, 95% CI [-12.34, -1.10], t(2068) = -2.34, p = 0.019;
## Std. beta = -0.72, 95% CI [-1.33, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.64, 95% CI [-33.14, 9.87], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-10.18, 8.53], t(2068) = -0.17, p = 0.862; Std.
## beta = -0.09, 95% CI [-1.09, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.57, 4.58], t(2068) = 0.24, p = 0.808; Std.
## beta = 0.05, 95% CI [-0.38, 0.49])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-10.94, 2.37], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.46, 95% CI [-1.17, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.77, 10.44], t(2068) = 0.73, p = 0.465; Std.
## beta = 0.30, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-5.57, 4.04], t(2068) = -0.31, p = 0.754; Std.
## beta = -0.08, 95% CI [-0.60, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.51, 95% CI [3.24, 19.78], t(2068) = 2.73, p = 0.006; Std.
## beta = 1.24, 95% CI [0.35, 2.12])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-2.62, 8.77], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.33, 95% CI [-0.28, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.12, 2.95], t(2068) = -0.92, p = 0.359; Std.
## beta = -0.28, 95% CI [-0.87, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.25, 95% CI [-7.11, 0.61], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.35, 95% CI [-0.76, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.40, 95% CI [-63.26, -29.55], t(2068) = -5.40, p < .001;
## Std. beta = -4.99, 95% CI [-6.80, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.18, 8.58], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-0.99, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.99, 11.86], t(2068) = 0.17, p = 0.867; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.54, 11.68], t(2068) = 0.20, p = 0.843; Std.
## beta = 0.11, 95% CI [-1.03, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.21. The model's intercept, corresponding to site =
## Simmons, is at 69.47 (95% CI [62.28, 76.65], t(2068) = 18.97, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.85, 95% CI [-6.34, -1.36], t(2068) = -3.03, p = 0.002; Std. beta = -0.43,
## 95% CI [-0.58, -0.29])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.72, 95% CI [-4.57, -0.88], t(2068) = -2.90, p = 0.004; Std. beta =
## -0.26, 95% CI [-0.43, -0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -15.81, 95% CI [-48.97, 17.35], t(2068) = -0.94, p = 0.350; Std. beta =
## -2.30, 95% CI [-5.11, 0.50])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-18.24, 29.90], t(2068) = 0.47, p = 0.635; Std. beta = 0.46,
## 95% CI [-0.98, 1.91])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-26.23, 20.25], t(2068) = -0.25, p = 0.801; Std. beta = -0.65,
## 95% CI [-2.17, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.16, 95% CI [-35.35, 3.02], t(2068) = -1.65, p = 0.099; Std. beta = -1.05,
## 95% CI [-2.43, 0.34])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 15.11, 95% CI [-8.38, 38.59], t(2068) = 1.26, p = 0.207; Std. beta = 0.60,
## 95% CI [-0.90, 2.11])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.30, 95% CI [-3.87, 16.48], t(2068) = 1.22, p = 0.224; Std. beta = 5.64e-03,
## 95% CI [-0.61, 0.62])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.68, 95% CI [-8.80, 38.16], t(2068) = 1.23, p = 0.220; Std. beta = 0.28,
## 95% CI [-1.20, 1.75])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-11.35, 4.18], t(2068) = -0.91, p = 0.365; Std. beta = -0.30,
## 95% CI [-0.77, 0.18])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.33, 16.01], t(2068) = 0.34, p = 0.737; Std. beta = -0.12,
## 95% CI [-0.95, 0.72])
## - The effect of site [103] is statistically significant and negative (beta =
## -9.57, 95% CI [-17.46, -1.68], t(2068) = -2.38, p = 0.018; Std. beta = -0.42,
## 95% CI [-0.90, 0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.38, 95% CI [-28.30, -0.47], t(2068) = -2.03, p = 0.043; Std. beta = -0.30,
## 95% CI [-1.25, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.73, 95% CI [-10.61, 5.16], t(2068) = -0.68, p = 0.498; Std. beta = -0.21,
## 95% CI [-0.70, 0.27])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.85, 95% CI [-18.96, -0.75], t(2068) = -2.12, p = 0.034; Std. beta = -0.42,
## 95% CI [-0.97, 0.14])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-35.91, 11.47], t(2068) = -1.01, p = 0.312; Std. beta =
## -0.06, 95% CI [-1.66, 1.54])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.48, 95% CI [-28.03, 11.07], t(2068) = -0.85, p = 0.395; Std. beta = 0.06,
## 95% CI [-1.12, 1.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.84, 95% CI [-27.38, 41.06], t(2068) = 0.39, p = 0.695; Std. beta = 0.40,
## 95% CI [-1.61, 2.42])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.45, 95% CI [-6.50, 23.39], t(2068) = 1.11, p = 0.268; Std. beta = 0.75, 95%
## CI [-0.18, 1.69])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-19.60, 27.44], t(2068) = 0.33, p = 0.744; Std. beta = 0.18,
## 95% CI [-1.30, 1.66])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 9.94, 95% CI [-7.78, 27.65], t(2068) = 1.10, p = 0.271; Std. beta = 0.40, 95%
## CI [-0.69, 1.48])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-29.02, 30.07], t(2068) = 0.03, p = 0.972; Std. beta = 0.31,
## 95% CI [-2.31, 2.93])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.82, 95% CI [-66.86, -0.78], t(2068) = -2.01, p = 0.045; Std. beta = -2.27,
## 95% CI [-4.66, 0.11])
## - The effect of site [16R] is statistically significant and negative (beta =
## -21.56, 95% CI [-36.78, -6.34], t(2068) = -2.78, p = 0.006; Std. beta = -1.08,
## 95% CI [-2.04, -0.13])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-32.98, 33.04], t(2068) = 1.89e-03, p = 0.998; Std. beta =
## 1.87e-03, 95% CI [-1.95, 1.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.35, 95% CI [-28.90, 18.21], t(2068) = -0.45, p = 0.656; Std. beta = 0.26,
## 95% CI [-1.86, 2.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-15.94, 15.79], t(2068) = -9.46e-03, p = 0.992; Std. beta =
## 0.27, 95% CI [-0.81, 1.35])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.65, 95% CI [-16.82, 11.51], t(2068) = -0.37, p = 0.713; Std. beta = -0.11,
## 95% CI [-1.02, 0.81])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-33.68, 30.54], t(2068) = -0.10, p = 0.924; Std. beta = 0.28,
## 95% CI [-1.63, 2.19])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.64, 95% CI [-15.63, 6.34], t(2068) = -0.83, p = 0.407; Std. beta = -0.61,
## 95% CI [-1.33, 0.11])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.10, 95% CI [-31.36, -0.84], t(2068) = -2.07, p = 0.039; Std. beta = -0.84,
## 95% CI [-1.99, 0.31])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.34, 95% CI [-14.73, 12.04], t(2068) = -0.20, p = 0.844; Std. beta = -0.10,
## 95% CI [-0.93, 0.72])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-20.88, 8.22], t(2068) = -0.85, p = 0.394; Std. beta = -0.97,
## 95% CI [-1.87, -0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-23.48, 15.14], t(2068) = -0.42, p = 0.672; Std. beta = -1.28,
## 95% CI [-3.36, 0.79])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-43.84, 21.79], t(2068) = -0.66, p = 0.510; Std. beta =
## -0.72, 95% CI [-2.65, 1.20])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-17.58, 12.69], t(2068) = -0.32, p = 0.751; Std. beta = -0.10,
## 95% CI [-1.00, 0.80])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-13.45, 21.08], t(2068) = 0.43, p = 0.665; Std. beta = -0.16,
## 95% CI [-1.24, 0.92])
## - The effect of site [33R] is statistically significant and negative (beta =
## -21.00, 95% CI [-37.67, -4.33], t(2068) = -2.47, p = 0.014; Std. beta = -0.99,
## 95% CI [-2.10, 0.12])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.01, 95% CI [-17.16, 9.14], t(2068) = -0.60, p = 0.550; Std. beta = -0.30,
## 95% CI [-1.12, 0.51])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-21.40, 17.93], t(2068) = -0.17, p = 0.863; Std. beta = 0.92,
## 95% CI [-0.31, 2.16])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.50, -3.19], t(2068) = -2.37, p = 0.018; Std. beta = -0.81,
## 95% CI [-1.77, 0.15])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-10.35, 23.18], t(2068) = 0.75, p = 0.453; Std. beta = 0.15,
## 95% CI [-0.87, 1.17])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-5.56, 17.98], t(2068) = 1.04, p = 0.301; Std. beta = 0.08, 95%
## CI [-0.64, 0.79])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.89, 95% CI [-23.06, 42.84], t(2068) = 0.59, p = 0.556; Std. beta = -3.55,
## 95% CI [-5.72, -1.38])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.27, 95% CI [-2.14, 44.69], t(2068) = 1.78, p = 0.075; Std. beta = 1.23,
## 95% CI [-0.27, 2.73])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-27.12, 11.69], t(2068) = -0.78, p = 0.436; Std. beta = -0.37,
## 95% CI [-1.71, 0.96])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.81, 4.83], t(2068) = -1.09, p = 0.278; Std. beta = -0.26,
## 95% CI [-1.24, 0.73])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.09, 95% CI [-0.75, 0.57], t(2068) =
## -0.26, p = 0.794; Std. beta = -0.01, 95% CI [-0.12, 0.09])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.36, 95% CI [-44.28, 13.56], t(2068) = -1.04, p = 0.298;
## Std. beta = -1.65, 95% CI [-4.76, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.66, 11.33], t(2068) = 0.26, p = 0.793; Std.
## beta = 0.14, 95% CI [-0.93, 1.22])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.28, 95% CI [-16.17, 5.61], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.57, 95% CI [-1.74, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-13.25, 11.20], t(2068) = -0.16, p = 0.869;
## Std. beta = -0.11, 95% CI [-1.42, 1.20])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.21, 95% CI [-12.66, 6.23], t(2068) = -0.67, p = 0.505; Std.
## beta = -0.35, 95% CI [-1.36, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.11, 95% CI [-7.19, -1.03], t(2068) = -2.61, p = 0.009; Std.
## beta = -0.44, 95% CI [-0.77, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-15.04, 1.82], t(2068) = -1.54, p = 0.124; Std.
## beta = -0.71, 95% CI [-1.62, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.52, 1.64], t(2068) = -0.71, p = 0.475; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-7.38, 1.70], t(2068) = -1.23, p = 0.220; Std.
## beta = -0.31, 95% CI [-0.79, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-1.06, 4.39], t(2068) = 1.20, p = 0.231; Std.
## beta = 0.18, 95% CI [-0.11, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.13, 95% CI [-0.91, 13.17], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.66, 95% CI [-0.10, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-3.21, 2.08], t(2068) = -0.42, p = 0.674; Std.
## beta = -0.06, 95% CI [-0.35, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.53, 5.24], t(2068) = 1.07, p = 0.283; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.38, 95% CI [-5.84, 20.59], t(2068) = 1.09, p = 0.274; Std.
## beta = 0.79, 95% CI [-0.63, 2.21])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-3.96e-03, 12.57], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.68, 95% CI [-4.28e-04, 1.35])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-2.62, 8.33], t(2068) = 1.02, p = 0.307; Std.
## beta = 0.31, 95% CI [-0.28, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.75, 7.61], t(2068) = -0.14, p = 0.891; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-10.11, 5.90], t(2068) = -0.52, p = 0.606; Std.
## beta = -0.23, 95% CI [-1.09, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-34.01, 40.21], t(2068) = 0.16, p = 0.870; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-25.44, 19.18], t(2068) = -0.27, p = 0.783;
## Std. beta = -0.34, 95% CI [-2.73, 2.06])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-3.25, 7.50], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.23, 95% CI [-0.35, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.46, 95% CI [-14.69, 27.60], t(2068) = 0.60, p = 0.549; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.35, 11.49], t(2068) = 0.71, p = 0.475; Std.
## beta = 0.33, 95% CI [-0.57, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-5.77, 6.91], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.06, 95% CI [-0.62, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.65, 13.11], t(2068) = 0.93, p = 0.350; Std.
## beta = 0.45, 95% CI [-0.50, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.73, 95% CI [-9.12, 1.65], t(2068) = -1.36, p = 0.174; Std.
## beta = -0.40, 95% CI [-0.98, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.61, 11.11], t(2068) = 0.25, p = 0.804; Std.
## beta = 0.13, 95% CI [-0.93, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.11, 4.55], t(2068) = -0.11, p = 0.911; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.72, 95% CI [-12.34, -1.10], t(2068) = -2.34, p = 0.019;
## Std. beta = -0.72, 95% CI [-1.33, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.64, 95% CI [-33.14, 9.87], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-10.18, 8.53], t(2068) = -0.17, p = 0.862; Std.
## beta = -0.09, 95% CI [-1.09, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.57, 4.58], t(2068) = 0.24, p = 0.808; Std.
## beta = 0.05, 95% CI [-0.38, 0.49])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-10.94, 2.37], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.46, 95% CI [-1.17, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.77, 10.44], t(2068) = 0.73, p = 0.465; Std.
## beta = 0.30, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-5.57, 4.04], t(2068) = -0.31, p = 0.754; Std.
## beta = -0.08, 95% CI [-0.60, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.51, 95% CI [3.24, 19.78], t(2068) = 2.73, p = 0.006; Std.
## beta = 1.24, 95% CI [0.35, 2.12])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-2.62, 8.77], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.33, 95% CI [-0.28, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.12, 2.95], t(2068) = -0.92, p = 0.359; Std.
## beta = -0.28, 95% CI [-0.87, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.25, 95% CI [-7.11, 0.61], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.35, 95% CI [-0.76, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.40, 95% CI [-63.26, -29.55], t(2068) = -5.40, p < .001;
## Std. beta = -4.99, 95% CI [-6.80, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.18, 8.58], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-0.99, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.99, 11.86], t(2068) = 0.17, p = 0.867; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.54, 11.68], t(2068) = 0.20, p = 0.843; Std.
## beta = 0.11, 95% CI [-1.03, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to cohort = CARE-PF, is at 69.47 (95% CI [62.28, 76.65], t(2068)
## = 18.97, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.85, 95% CI [-6.34, -1.36], t(2068) = -3.03, p = 0.002; Std. beta = -0.43,
## 95% CI [-0.58, -0.29])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.72, 95% CI [-4.57, -0.88], t(2068) = -2.90, p = 0.004; Std. beta =
## -0.26, 95% CI [-0.43, -0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -15.81, 95% CI [-48.97, 17.35], t(2068) = -0.94, p = 0.350; Std. beta =
## -2.30, 95% CI [-5.11, 0.50])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-18.24, 29.90], t(2068) = 0.47, p = 0.635; Std. beta = 0.46,
## 95% CI [-0.98, 1.91])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-26.23, 20.25], t(2068) = -0.25, p = 0.801; Std. beta = -0.65,
## 95% CI [-2.17, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.16, 95% CI [-35.35, 3.02], t(2068) = -1.65, p = 0.099; Std. beta = -1.05,
## 95% CI [-2.43, 0.34])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 15.11, 95% CI [-8.38, 38.59], t(2068) = 1.26, p = 0.207; Std. beta = 0.60,
## 95% CI [-0.90, 2.11])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.30, 95% CI [-3.87, 16.48], t(2068) = 1.22, p = 0.224; Std. beta = 5.64e-03,
## 95% CI [-0.61, 0.62])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.68, 95% CI [-8.80, 38.16], t(2068) = 1.23, p = 0.220; Std. beta = 0.28,
## 95% CI [-1.20, 1.75])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-11.35, 4.18], t(2068) = -0.91, p = 0.365; Std. beta = -0.30,
## 95% CI [-0.77, 0.18])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 2.34, 95% CI [-11.33, 16.01], t(2068) = 0.34, p = 0.737; Std. beta = -0.12,
## 95% CI [-0.95, 0.72])
## - The effect of site [103] is statistically significant and negative (beta =
## -9.57, 95% CI [-17.46, -1.68], t(2068) = -2.38, p = 0.018; Std. beta = -0.42,
## 95% CI [-0.90, 0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.38, 95% CI [-28.30, -0.47], t(2068) = -2.03, p = 0.043; Std. beta = -0.30,
## 95% CI [-1.25, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.73, 95% CI [-10.61, 5.16], t(2068) = -0.68, p = 0.498; Std. beta = -0.21,
## 95% CI [-0.70, 0.27])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.85, 95% CI [-18.96, -0.75], t(2068) = -2.12, p = 0.034; Std. beta = -0.42,
## 95% CI [-0.97, 0.14])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-35.91, 11.47], t(2068) = -1.01, p = 0.312; Std. beta =
## -0.06, 95% CI [-1.66, 1.54])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.48, 95% CI [-28.03, 11.07], t(2068) = -0.85, p = 0.395; Std. beta = 0.06,
## 95% CI [-1.12, 1.24])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.84, 95% CI [-27.38, 41.06], t(2068) = 0.39, p = 0.695; Std. beta = 0.40,
## 95% CI [-1.61, 2.42])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.45, 95% CI [-6.50, 23.39], t(2068) = 1.11, p = 0.268; Std. beta = 0.75, 95%
## CI [-0.18, 1.69])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-19.60, 27.44], t(2068) = 0.33, p = 0.744; Std. beta = 0.18,
## 95% CI [-1.30, 1.66])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 9.94, 95% CI [-7.78, 27.65], t(2068) = 1.10, p = 0.271; Std. beta = 0.40, 95%
## CI [-0.69, 1.48])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-29.02, 30.07], t(2068) = 0.03, p = 0.972; Std. beta = 0.31,
## 95% CI [-2.31, 2.93])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.82, 95% CI [-66.86, -0.78], t(2068) = -2.01, p = 0.045; Std. beta = -2.27,
## 95% CI [-4.66, 0.11])
## - The effect of site [16R] is statistically significant and negative (beta =
## -21.56, 95% CI [-36.78, -6.34], t(2068) = -2.78, p = 0.006; Std. beta = -1.08,
## 95% CI [-2.04, -0.13])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-32.98, 33.04], t(2068) = 1.89e-03, p = 0.998; Std. beta =
## 1.87e-03, 95% CI [-1.95, 1.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.35, 95% CI [-28.90, 18.21], t(2068) = -0.45, p = 0.656; Std. beta = 0.26,
## 95% CI [-1.86, 2.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -0.08, 95% CI [-15.94, 15.79], t(2068) = -9.46e-03, p = 0.992; Std. beta =
## 0.27, 95% CI [-0.81, 1.35])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.65, 95% CI [-16.82, 11.51], t(2068) = -0.37, p = 0.713; Std. beta = -0.11,
## 95% CI [-1.02, 0.81])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-33.68, 30.54], t(2068) = -0.10, p = 0.924; Std. beta = 0.28,
## 95% CI [-1.63, 2.19])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.64, 95% CI [-15.63, 6.34], t(2068) = -0.83, p = 0.407; Std. beta = -0.61,
## 95% CI [-1.33, 0.11])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.10, 95% CI [-31.36, -0.84], t(2068) = -2.07, p = 0.039; Std. beta = -0.84,
## 95% CI [-1.99, 0.31])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.34, 95% CI [-14.73, 12.04], t(2068) = -0.20, p = 0.844; Std. beta = -0.10,
## 95% CI [-0.93, 0.72])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-20.88, 8.22], t(2068) = -0.85, p = 0.394; Std. beta = -0.97,
## 95% CI [-1.87, -0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-23.48, 15.14], t(2068) = -0.42, p = 0.672; Std. beta = -1.28,
## 95% CI [-3.36, 0.79])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-43.84, 21.79], t(2068) = -0.66, p = 0.510; Std. beta =
## -0.72, 95% CI [-2.65, 1.20])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-17.58, 12.69], t(2068) = -0.32, p = 0.751; Std. beta = -0.10,
## 95% CI [-1.00, 0.80])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-13.45, 21.08], t(2068) = 0.43, p = 0.665; Std. beta = -0.16,
## 95% CI [-1.24, 0.92])
## - The effect of site [33R] is statistically significant and negative (beta =
## -21.00, 95% CI [-37.67, -4.33], t(2068) = -2.47, p = 0.014; Std. beta = -0.99,
## 95% CI [-2.10, 0.12])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.01, 95% CI [-17.16, 9.14], t(2068) = -0.60, p = 0.550; Std. beta = -0.30,
## 95% CI [-1.12, 0.51])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-21.40, 17.93], t(2068) = -0.17, p = 0.863; Std. beta = 0.92,
## 95% CI [-0.31, 2.16])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.50, -3.19], t(2068) = -2.37, p = 0.018; Std. beta = -0.81,
## 95% CI [-1.77, 0.15])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-10.35, 23.18], t(2068) = 0.75, p = 0.453; Std. beta = 0.15,
## 95% CI [-0.87, 1.17])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 6.21, 95% CI [-5.56, 17.98], t(2068) = 1.04, p = 0.301; Std. beta = 0.08, 95%
## CI [-0.64, 0.79])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.89, 95% CI [-23.06, 42.84], t(2068) = 0.59, p = 0.556; Std. beta = -3.55,
## 95% CI [-5.72, -1.38])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.27, 95% CI [-2.14, 44.69], t(2068) = 1.78, p = 0.075; Std. beta = 1.23,
## 95% CI [-0.27, 2.73])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-27.12, 11.69], t(2068) = -0.78, p = 0.436; Std. beta = -0.37,
## 95% CI [-1.71, 0.96])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.81, 4.83], t(2068) = -1.09, p = 0.278; Std. beta = -0.26,
## 95% CI [-1.24, 0.73])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.09, 95% CI [-0.75, 0.57], t(2068) =
## -0.26, p = 0.794; Std. beta = -0.01, 95% CI [-0.12, 0.09])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.36, 95% CI [-44.28, 13.56], t(2068) = -1.04, p = 0.298;
## Std. beta = -1.65, 95% CI [-4.76, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-8.66, 11.33], t(2068) = 0.26, p = 0.793; Std.
## beta = 0.14, 95% CI [-0.93, 1.22])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.28, 95% CI [-16.17, 5.61], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.57, 95% CI [-1.74, 0.60])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-13.25, 11.20], t(2068) = -0.16, p = 0.869;
## Std. beta = -0.11, 95% CI [-1.42, 1.20])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.21, 95% CI [-12.66, 6.23], t(2068) = -0.67, p = 0.505; Std.
## beta = -0.35, 95% CI [-1.36, 0.67])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.11, 95% CI [-7.19, -1.03], t(2068) = -2.61, p = 0.009; Std.
## beta = -0.44, 95% CI [-0.77, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-15.04, 1.82], t(2068) = -1.54, p = 0.124; Std.
## beta = -0.71, 95% CI [-1.62, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.52, 1.64], t(2068) = -0.71, p = 0.475; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-7.38, 1.70], t(2068) = -1.23, p = 0.220; Std.
## beta = -0.31, 95% CI [-0.79, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-1.06, 4.39], t(2068) = 1.20, p = 0.231; Std.
## beta = 0.18, 95% CI [-0.11, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.13, 95% CI [-0.91, 13.17], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.66, 95% CI [-0.10, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-3.21, 2.08], t(2068) = -0.42, p = 0.674; Std.
## beta = -0.06, 95% CI [-0.35, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.53, 5.24], t(2068) = 1.07, p = 0.283; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.38, 95% CI [-5.84, 20.59], t(2068) = 1.09, p = 0.274; Std.
## beta = 0.79, 95% CI [-0.63, 2.21])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.28, 95% CI [-3.96e-03, 12.57], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.68, 95% CI [-4.28e-04, 1.35])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-2.62, 8.33], t(2068) = 1.02, p = 0.307; Std.
## beta = 0.31, 95% CI [-0.28, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-8.75, 7.61], t(2068) = -0.14, p = 0.891; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-10.11, 5.90], t(2068) = -0.52, p = 0.606; Std.
## beta = -0.23, 95% CI [-1.09, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-34.01, 40.21], t(2068) = 0.16, p = 0.870; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-25.44, 19.18], t(2068) = -0.27, p = 0.783;
## Std. beta = -0.34, 95% CI [-2.73, 2.06])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-3.25, 7.50], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.23, 95% CI [-0.35, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.46, 95% CI [-14.69, 27.60], t(2068) = 0.60, p = 0.549; Std.
## beta = 0.69, 95% CI [-1.58, 2.96])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.35, 11.49], t(2068) = 0.71, p = 0.475; Std.
## beta = 0.33, 95% CI [-0.57, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-5.77, 6.91], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.06, 95% CI [-0.62, 0.74])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.65, 13.11], t(2068) = 0.93, p = 0.350; Std.
## beta = 0.45, 95% CI [-0.50, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.73, 95% CI [-9.12, 1.65], t(2068) = -1.36, p = 0.174; Std.
## beta = -0.40, 95% CI [-0.98, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-8.61, 11.11], t(2068) = 0.25, p = 0.804; Std.
## beta = 0.13, 95% CI [-0.93, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-5.11, 4.55], t(2068) = -0.11, p = 0.911; Std.
## beta = -0.03, 95% CI [-0.55, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.72, 95% CI [-12.34, -1.10], t(2068) = -2.34, p = 0.019;
## Std. beta = -0.72, 95% CI [-1.33, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.64, 95% CI [-33.14, 9.87], t(2068) = -1.06, p = 0.289;
## Std. beta = -1.25, 95% CI [-3.56, 1.06])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-10.18, 8.53], t(2068) = -0.17, p = 0.862; Std.
## beta = -0.09, 95% CI [-1.09, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-3.57, 4.58], t(2068) = 0.24, p = 0.808; Std.
## beta = 0.05, 95% CI [-0.38, 0.49])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-10.94, 2.37], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.46, 95% CI [-1.17, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.77, 10.44], t(2068) = 0.73, p = 0.465; Std.
## beta = 0.30, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-5.57, 4.04], t(2068) = -0.31, p = 0.754; Std.
## beta = -0.08, 95% CI [-0.60, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.51, 95% CI [3.24, 19.78], t(2068) = 2.73, p = 0.006; Std.
## beta = 1.24, 95% CI [0.35, 2.12])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-2.62, 8.77], t(2068) = 1.06, p = 0.289; Std.
## beta = 0.33, 95% CI [-0.28, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.12, 2.95], t(2068) = -0.92, p = 0.359; Std.
## beta = -0.28, 95% CI [-0.87, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.25, 95% CI [-7.11, 0.61], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.35, 95% CI [-0.76, 0.07])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.40, 95% CI [-63.26, -29.55], t(2068) = -5.40, p < .001;
## Std. beta = -4.99, 95% CI [-6.80, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.18, 8.58], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-0.99, 0.92])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.99, 11.86], t(2068) = 0.17, p = 0.867; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.54, 11.68], t(2068) = 0.20, p = 0.843; Std.
## beta = 0.11, 95% CI [-1.03, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*SO4_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14368.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2907 -0.4417 -0.0141 0.4452 4.4986
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 229.66 15.154
## time_firstPFT 13.58 3.686 -0.08
## Residual 25.62 5.062
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 40.46811 6.82987 5.925
## time_firstPFT -0.77976 2.54085 -0.307
## SO4_5yrPreCensor -2.38999 0.93828 -2.547
## disadv 3.09394 2.88496 1.072
## dich_RaceNon-White -6.72061 2.78634 -2.412
## sexF 3.90287 1.73232 2.253
## age_dx 0.39302 0.09050 4.343
## smokeHxFormer 3.70515 1.71845 2.156
## smokeHxAlways 18.53401 8.35977 2.217
## smokeHxUnknown -0.61408 3.97329 -0.155
## site02R -18.44697 16.32443 -1.130
## site03R 4.87874 11.94555 0.408
## site04R -2.27635 11.36624 -0.200
## site05R -16.74560 9.42627 -1.776
## site06R 6.58369 16.12140 0.408
## site07R 6.10543 5.02059 1.216
## site09R 14.17577 11.56269 1.226
## site101 -1.54103 3.84413 -0.401
## site102 4.69081 6.80511 0.689
## site103 -8.85398 4.00101 -2.213
## site104 -14.76884 6.86224 -2.152
## site105 -1.75950 3.89072 -0.452
## site106 -10.85117 4.56354 -2.378
## site107 -8.57610 11.65296 -0.736
## site108 -2.93358 10.01035 -0.293
## site10R 4.81499 17.07054 0.282
## site11R 5.84501 7.32457 0.798
## site12R 0.65989 11.51337 0.057
## site13R 12.12291 8.76963 1.382
## site14R 0.18209 14.73890 0.012
## site15R -39.22874 16.22960 -2.417
## site16R -14.81124 7.58305 -1.953
## site17R 5.04134 16.32596 0.309
## site18R -7.93885 11.56377 -0.687
## site19R 0.57621 7.84082 0.073
## site20R -3.23196 6.96637 -0.464
## site21R -2.00074 15.67741 -0.128
## site22R -7.79583 5.49497 -1.419
## site23R -18.17836 8.96812 -2.027
## site24R -1.52687 6.57178 -0.232
## site25R -6.43541 7.25645 -0.887
## site28R 0.04108 9.51482 0.004
## site29R -12.89259 16.14213 -0.799
## site31R -0.62440 7.52764 -0.083
## site32R 2.20268 8.51669 0.259
## site33R -18.66002 8.19765 -2.276
## site34R -5.54147 6.44515 -0.860
## site35R -7.16794 9.68637 -0.740
## site36R -16.39254 7.44902 -2.201
## site37R 9.92902 8.31297 1.194
## site38R 6.99695 5.76774 1.213
## site39R 15.83135 16.43335 0.963
## site40R 19.66353 11.47128 1.714
## site41R -9.27321 9.60289 -0.966
## site42R -5.89766 5.38864 -1.094
## time_firstPFT:SO4_5yrPreCensor -0.14792 0.36244 -0.408
## time_firstPFT:disadv -0.04301 1.11580 -0.039
## time_firstPFT:dich_RaceNon-White 0.13185 1.11656 0.118
## time_firstPFT:sexF 0.02623 0.66077 0.040
## time_firstPFT:age_dx -0.05979 0.03466 -1.725
## time_firstPFT:smokeHxFormer 0.52483 0.67527 0.777
## time_firstPFT:smokeHxAlways 1.35732 5.29720 0.256
## time_firstPFT:smokeHxUnknown 1.81774 1.72192 1.056
## time_firstPFT:site02R -14.72520 14.80024 -0.995
## time_firstPFT:site03R 2.53116 5.19708 0.487
## time_firstPFT:site04R -4.95518 5.63979 -0.879
## time_firstPFT:site05R -0.81040 6.27977 -0.129
## time_firstPFT:site07R -3.68135 1.64465 -2.238
## time_firstPFT:site09R -6.51752 4.40007 -1.481
## time_firstPFT:site101 -0.86943 1.35020 -0.644
## time_firstPFT:site102 -3.08139 2.39869 -1.285
## time_firstPFT:site103 1.70767 1.47327 1.159
## time_firstPFT:site104 6.46653 3.67739 1.758
## time_firstPFT:site105 -0.62729 1.38580 -0.453
## time_firstPFT:site106 2.38600 1.80442 1.322
## time_firstPFT:site107 7.36688 6.79171 1.085
## time_firstPFT:site108 6.10417 3.45454 1.767
## time_firstPFT:site11R 3.66636 2.88817 1.269
## time_firstPFT:site12R -0.25933 4.26569 -0.061
## time_firstPFT:site13R -1.66882 4.17291 -0.400
## time_firstPFT:site14R 3.44597 18.96196 0.182
## time_firstPFT:site15R -2.96784 11.42396 -0.260
## time_firstPFT:site16R 1.75827 2.84789 0.617
## time_firstPFT:site18R 6.88155 10.82137 0.636
## time_firstPFT:site19R 4.25425 4.41378 0.964
## time_firstPFT:site20R 1.27103 3.33031 0.382
## time_firstPFT:site21R 4.32691 4.60414 0.940
## time_firstPFT:site22R -2.89212 2.83450 -1.020
## time_firstPFT:site23R 8.56931 24.66641 0.347
## time_firstPFT:site24R -0.30814 2.50690 -0.123
## time_firstPFT:site25R -6.07567 2.97539 -2.042
## time_firstPFT:site28R -10.16562 11.08620 -0.917
## time_firstPFT:site29R -0.29865 4.89678 -0.061
## time_firstPFT:site31R 0.52622 2.18640 0.241
## time_firstPFT:site32R -3.70764 3.47680 -1.066
## time_firstPFT:site33R 3.36037 3.99216 0.842
## time_firstPFT:site34R -0.65025 2.50617 -0.259
## time_firstPFT:site35R 12.34577 4.30065 2.871
## time_firstPFT:site36R 3.32711 2.96887 1.121
## time_firstPFT:site37R -1.94432 2.97467 -0.654
## time_firstPFT:site38R -3.09639 2.00948 -1.541
## time_firstPFT:site39R -47.07843 8.73083 -5.392
## time_firstPFT:site40R 0.68582 4.65664 0.147
## time_firstPFT:site41R 1.65465 5.62879 0.294
## time_firstPFT:site42R 1.95780 5.43751 0.360##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.919
## Unadjusted ICC: 0.695report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SO4_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.24. The model's intercept,
## corresponding to time_firstPFT = 0, is at 40.47 (95% CI [27.07, 53.86], t(2038)
## = 5.93, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SO4_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to
## SO4_5yrPreCensor = 0, is at 40.47 (95% CI [27.07, 53.86], t(2038) = 5.93, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to disadv = 0, is at 40.47 (95% CI [27.07,
## 53.86], t(2038) = 5.93, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to dich_Race =
## White, is at 40.47 (95% CI [27.07, 53.86], t(2038) = 5.93, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to sex = M, is at 40.47 (95% CI [27.07,
## 53.86], t(2038) = 5.93, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to age_dx = 0, is at 40.47 (95% CI [27.07,
## 53.86], t(2038) = 5.93, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to smokeHx =
## Never, is at 40.47 (95% CI [27.07, 53.86], t(2038) = 5.93, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to site = Simmons, is at 40.47 (95% CI [27.07,
## 53.86], t(2038) = 5.93, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to cohort =
## CARE-PF, is at 40.47 (95% CI [27.07, 53.86], t(2038) = 5.93, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.78, 95% CI [-5.76, 4.20], t(2038) = -0.31, p = 0.759; Std. beta =
## -0.50, 95% CI [-0.69, -0.30])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -2.39, 95% CI [-4.23, -0.55], t(2038) = -2.55, p = 0.011; Std. beta =
## -0.24, 95% CI [-0.42, -0.05])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.09, 95% CI [-2.56, 8.75], t(2038) = 1.07, p = 0.284; Std. beta = 0.05, 95% CI
## [-0.05, 0.15])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.72, 95% CI [-12.18, -1.26], t(2038) = -2.41, p = 0.016; Std. beta =
## -0.38, 95% CI [-0.74, -0.03])
## - The effect of sex [F] is statistically significant and positive (beta = 3.90,
## 95% CI [0.51, 7.30], t(2038) = 2.25, p = 0.024; Std. beta = 0.23, 95% CI [0.02,
## 0.45])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.34, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.34, 7.08], t(2038) = 2.16, p = 0.031; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.53, 95% CI [2.14, 34.93], t(2038) = 2.22, p = 0.027; Std. beta =
## 1.21, 95% CI [0.01, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.61, 95% CI [-8.41, 7.18], t(2038) = -0.15, p = 0.877; Std. beta =
## 0.13, 95% CI [-0.39, 0.64])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -18.45, 95% CI [-50.46, 13.57], t(2038) = -1.13, p = 0.259; Std. beta =
## -2.41, 95% CI [-5.20, 0.38])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-18.55, 28.31], t(2038) = 0.41, p = 0.683; Std. beta = 0.51,
## 95% CI [-0.91, 1.94])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-24.57, 20.01], t(2038) = -0.20, p = 0.841; Std. beta = -0.58,
## 95% CI [-2.08, 0.92])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -16.75, 95% CI [-35.23, 1.74], t(2038) = -1.78, p = 0.076; Std. beta = -1.06,
## 95% CI [-2.43, 0.31])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-25.03, 38.20], t(2038) = 0.41, p = 0.683; Std. beta = 0.39,
## 95% CI [-1.48, 2.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.11, 95% CI [-3.74, 15.95], t(2038) = 1.22, p = 0.224; Std. beta = 0.03, 95%
## CI [-0.58, 0.64])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-8.50, 36.85], t(2038) = 1.23, p = 0.220; Std. beta = 0.25,
## 95% CI [-1.20, 1.71])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -1.54, 95% CI [-9.08, 6.00], t(2038) = -0.40, p = 0.689; Std. beta = -0.17,
## 95% CI [-0.64, 0.30])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-8.65, 18.04], t(2038) = 0.69, p = 0.491; Std. beta = 8.23e-04,
## 95% CI [-0.83, 0.83])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.85, 95% CI [-16.70, -1.01], t(2038) = -2.21, p = 0.027; Std. beta = -0.37,
## 95% CI [-0.87, 0.13])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.77, 95% CI [-28.23, -1.31], t(2038) = -2.15, p = 0.031; Std. beta = -0.29,
## 95% CI [-1.24, 0.65])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.76, 95% CI [-9.39, 5.87], t(2038) = -0.45, p = 0.651; Std. beta = -0.16,
## 95% CI [-0.64, 0.32])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.85, 95% CI [-19.80, -1.90], t(2038) = -2.38, p = 0.018; Std. beta = -0.43,
## 95% CI [-0.99, 0.13])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-31.43, 14.28], t(2038) = -0.74, p = 0.462; Std. beta = 0.15,
## 95% CI [-1.42, 1.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.57, 16.70], t(2038) = -0.29, p = 0.770; Std. beta = 0.37,
## 95% CI [-0.83, 1.58])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-28.66, 38.29], t(2038) = 0.28, p = 0.778; Std. beta = 0.28,
## 95% CI [-1.69, 2.26])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-8.52, 20.21], t(2038) = 0.80, p = 0.425; Std. beta = 0.67, 95%
## CI [-0.25, 1.59])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 0.66, 95% CI [-21.92, 23.24], t(2038) = 0.06, p = 0.954; Std. beta = 0.02,
## 95% CI [-1.44, 1.47])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 12.12, 95% CI [-5.08, 29.32], t(2038) = 1.38, p = 0.167; Std. beta = 0.57,
## 95% CI [-0.51, 1.64])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-28.72, 29.09], t(2038) = 0.01, p = 0.990; Std. beta = 0.32,
## 95% CI [-2.30, 2.94])
## - The effect of site [15R] is statistically significant and negative (beta =
## -39.23, 95% CI [-71.06, -7.40], t(2038) = -2.42, p = 0.016; Std. beta = -2.58,
## 95% CI [-4.93, -0.23])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.81, 95% CI [-29.68, 0.06], t(2038) = -1.95, p = 0.051; Std. beta = -0.72,
## 95% CI [-1.67, 0.24])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.04, 95% CI [-26.98, 37.06], t(2038) = 0.31, p = 0.758; Std. beta = 0.30,
## 95% CI [-1.59, 2.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.94, 95% CI [-30.62, 14.74], t(2038) = -0.69, p = 0.492; Std. beta = 0.15,
## 95% CI [-1.96, 2.26])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 0.58, 95% CI [-14.80, 15.95], t(2038) = 0.07, p = 0.941; Std. beta = 0.41,
## 95% CI [-0.67, 1.50])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.23, 95% CI [-16.89, 10.43], t(2038) = -0.46, p = 0.643; Std. beta = -0.08,
## 95% CI [-0.98, 0.83])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -2.00, 95% CI [-32.75, 28.74], t(2038) = -0.13, p = 0.898; Std. beta = 0.27,
## 95% CI [-1.59, 2.13])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-18.57, 2.98], t(2038) = -1.42, p = 0.156; Std. beta = -0.72,
## 95% CI [-1.44, 4.74e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.18, 95% CI [-35.77, -0.59], t(2038) = -2.03, p = 0.043; Std. beta = -0.31,
## 95% CI [-4.36, 3.75])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.53, 95% CI [-14.41, 11.36], t(2038) = -0.23, p = 0.816; Std. beta = -0.12,
## 95% CI [-0.92, 0.69])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-20.67, 7.80], t(2038) = -0.89, p = 0.375; Std. beta = -0.92,
## 95% CI [-1.82, -0.02])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-18.62, 18.70], t(2038) = 4.32e-03, p = 0.997; Std. beta =
## -0.91, 95% CI [-3.00, 1.18])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.89, 95% CI [-44.55, 18.76], t(2038) = -0.80, p = 0.425; Std. beta =
## -0.79, 95% CI [-2.68, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.62, 95% CI [-15.39, 14.14], t(2038) = -0.08, p = 0.934; Std. beta = 0.01,
## 95% CI [-0.89, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-14.50, 18.90], t(2038) = 0.26, p = 0.796; Std. beta = -0.20,
## 95% CI [-1.27, 0.87])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.66, 95% CI [-34.74, -2.58], t(2038) = -2.28, p = 0.023; Std. beta = -0.80,
## 95% CI [-1.90, 0.30])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-18.18, 7.10], t(2038) = -0.86, p = 0.390; Std. beta = -0.39,
## 95% CI [-1.18, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -7.17, 95% CI [-26.16, 11.83], t(2038) = -0.74, p = 0.459; Std. beta = 0.68,
## 95% CI [-0.54, 1.90])
## - The effect of site [36R] is statistically significant and negative (beta =
## -16.39, 95% CI [-31.00, -1.78], t(2038) = -2.20, p = 0.028; Std. beta = -0.67,
## 95% CI [-1.61, 0.28])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.93, 95% CI [-6.37, 26.23], t(2038) = 1.19, p = 0.232; Std. beta = 0.41, 95%
## CI [-0.60, 1.42])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.00, 95% CI [-4.31, 18.31], t(2038) = 1.21, p = 0.225; Std. beta = 0.14, 95%
## CI [-0.57, 0.84])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-16.40, 48.06], t(2038) = 0.96, p = 0.335; Std. beta = -3.28,
## 95% CI [-5.45, -1.11])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 19.66, 95% CI [-2.83, 42.16], t(2038) = 1.71, p = 0.087; Std. beta = 1.22,
## 95% CI [-0.26, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-28.11, 9.56], t(2038) = -0.97, p = 0.334; Std. beta = -0.40,
## 95% CI [-1.72, 0.93])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-16.47, 4.67], t(2038) = -1.09, p = 0.274; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.15, 95% CI [-0.86, 0.56], t(2038) =
## -0.41, p = 0.683; Std. beta = -0.02, 95% CI [-0.14, 0.09])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.23, 2.15], t(2038) = -0.04, p = 0.969; Std.
## beta = -1.32e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.13, 95% CI [-2.06, 2.32], t(2038) =
## 0.12, p = 0.906; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-1.27, 1.32], t(2038) = 0.04, p = 0.968; Std.
## beta = 2.83e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.19e-03], t(2038) = -1.72, p = 0.085;
## Std. beta = -0.06, 95% CI [-0.13, 8.12e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.52, 95% CI [-0.80, 1.85], t(2038) =
## 0.78, p = 0.437; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.36, 95% CI [-9.03, 11.75], t(2038) =
## 0.26, p = 0.798; Std. beta = 0.15, 95% CI [-0.97, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.82, 95% CI [-1.56, 5.19], t(2038) =
## 1.06, p = 0.291; Std. beta = 0.20, 95% CI [-0.17, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.73, 95% CI [-43.75, 14.30], t(2038) = -0.99, p = 0.320;
## Std. beta = -1.59, 95% CI [-4.71, 1.54])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-7.66, 12.72], t(2038) = 0.49, p = 0.626; Std.
## beta = 0.27, 95% CI [-0.83, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.96, 95% CI [-16.02, 6.11], t(2038) = -0.88, p = 0.380; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-13.13, 11.51], t(2038) = -0.13, p = 0.897;
## Std. beta = -0.09, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.68, 95% CI [-6.91, -0.46], t(2038) = -2.24, p = 0.025; Std.
## beta = -0.40, 95% CI [-0.74, -0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.52, 95% CI [-15.15, 2.11], t(2038) = -1.48, p = 0.139; Std.
## beta = -0.70, 95% CI [-1.63, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-3.52, 1.78], t(2038) = -0.64, p = 0.520; Std.
## beta = -0.09, 95% CI [-0.38, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.79, 1.62], t(2038) = -1.28, p = 0.199; Std.
## beta = -0.33, 95% CI [-0.84, 0.17])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-1.18, 4.60], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.18, 95% CI [-0.13, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-0.75, 13.68], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.70, 95% CI [-0.08, 1.47])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-3.35, 2.09], t(2038) = -0.45, p = 0.651; Std.
## beta = -0.07, 95% CI [-0.36, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.39, 95% CI [-1.15, 5.92], t(2038) = 1.32, p = 0.186; Std.
## beta = 0.26, 95% CI [-0.12, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.37, 95% CI [-5.95, 20.69], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.23])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.10, 95% CI [-0.67, 12.88], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.66, 95% CI [-0.07, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.67, 95% CI [-2.00, 9.33], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.62, 8.11], t(2038) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.93, 0.87])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-9.85, 6.51], t(2038) = -0.40, p = 0.689; Std.
## beta = -0.18, 95% CI [-1.06, 0.70])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.45, 95% CI [-33.74, 40.63], t(2038) = 0.18, p = 0.856; Std.
## beta = 0.37, 95% CI [-3.63, 4.38])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-25.37, 19.44], t(2038) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.73, 2.09])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.76, 95% CI [-3.83, 7.34], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.19, 95% CI [-0.41, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.88, 95% CI [-14.34, 28.10], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.25, 95% CI [-4.40, 12.91], t(2038) = 0.96, p = 0.335; Std.
## beta = 0.46, 95% CI [-0.47, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.26, 7.80], t(2038) = 0.38, p = 0.703; Std.
## beta = 0.14, 95% CI [-0.57, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.70, 13.36], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.47, 95% CI [-0.51, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-8.45, 2.67], t(2038) = -1.02, p = 0.308; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.57, 95% CI [-39.80, 56.94], t(2038) = 0.35, p = 0.728; Std.
## beta = 0.92, 95% CI [-4.29, 6.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-5.22, 4.61], t(2038) = -0.12, p = 0.902; Std.
## beta = -0.03, 95% CI [-0.56, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.08, 95% CI [-11.91, -0.24], t(2038) = -2.04, p = 0.041;
## Std. beta = -0.65, 95% CI [-1.28, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-31.91, 11.58], t(2038) = -0.92, p = 0.359;
## Std. beta = -1.09, 95% CI [-3.44, 1.25])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-9.90, 9.30], t(2038) = -0.06, p = 0.951; Std.
## beta = -0.03, 95% CI [-1.07, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.53, 95% CI [-3.76, 4.81], t(2038) = 0.24, p = 0.810; Std.
## beta = 0.06, 95% CI [-0.41, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.71, 95% CI [-10.53, 3.11], t(2038) = -1.07, p = 0.286; Std.
## beta = -0.40, 95% CI [-1.13, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-4.47, 11.19], t(2038) = 0.84, p = 0.400; Std.
## beta = 0.36, 95% CI [-0.48, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-5.57, 4.26], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.60, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.35, 95% CI [3.91, 20.78], t(2038) = 2.87, p = 0.004; Std.
## beta = 1.33, 95% CI [0.42, 2.24])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.33, 95% CI [-2.50, 9.15], t(2038) = 1.12, p = 0.263; Std.
## beta = 0.36, 95% CI [-0.27, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.78, 3.89], t(2038) = -0.65, p = 0.513; Std.
## beta = -0.21, 95% CI [-0.84, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-7.04, 0.84], t(2038) = -1.54, p = 0.123; Std.
## beta = -0.33, 95% CI [-0.76, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-64.20, -29.96], t(2038) = -5.39, p < .001;
## Std. beta = -5.07, 95% CI [-6.91, -3.23])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-8.45, 9.82], t(2038) = 0.15, p = 0.883; Std.
## beta = 0.07, 95% CI [-0.91, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-9.38, 12.69], t(2038) = 0.29, p = 0.769; Std.
## beta = 0.18, 95% CI [-1.01, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.96, 95% CI [-8.71, 12.62], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.21, 95% CI [-0.94, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*NO3_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14558.4
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3285 -0.4341 -0.0165 0.4494 4.5145
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 256.56 16.017
## time_firstPFT 13.14 3.625 -0.13
## Residual 25.52 5.052
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 63.51336 3.14498 20.195
## time_firstPFT -2.25089 1.30917 -1.719
## NO3_5yrPreCensor -3.58899 2.59183 -1.385
## site02R -6.94180 16.82881 -0.412
## site03R 13.35451 12.06359 1.107
## site04R 5.43002 11.85692 0.458
## site05R -11.73679 9.71716 -1.208
## site06R 19.17964 11.96418 1.603
## site07R 13.35630 4.75114 2.811
## site09R 20.55266 11.85110 1.734
## site101 2.40642 3.26656 0.737
## site102 9.34194 6.43854 1.451
## site103 -3.55478 3.30072 -1.077
## site104 -8.63347 6.82576 -1.265
## site105 2.96175 3.36314 0.881
## site106 -3.82169 4.17905 -0.914
## site107 -6.52749 11.96479 -0.546
## site108 -2.46477 9.77902 -0.252
## site10R 9.64139 17.41045 0.554
## site11R 11.54834 7.65489 1.509
## site12R 10.52527 11.81558 0.891
## site13R 14.82854 8.89289 1.667
## site14R 6.18861 14.97869 0.413
## site15R -30.43214 16.96430 -1.794
## site16R -15.11300 7.49036 -2.018
## site17R 5.42273 16.84815 0.322
## site18R -1.76697 12.04782 -0.147
## site19R 5.01843 7.98612 0.628
## site20R 2.88016 6.96403 0.414
## site21R 2.28648 16.44706 0.139
## site22R 1.90189 5.27459 0.361
## site23R -12.47475 7.73174 -1.613
## site24R 6.41808 6.38305 1.005
## site25R 2.46669 6.95443 0.355
## site28R 1.06695 9.78161 0.109
## site29R -5.33540 16.71764 -0.319
## site31R 2.01798 7.59299 0.266
## site32R 9.71871 8.56396 1.135
## site33R -17.58131 8.48133 -2.073
## site34R 1.42400 6.41763 0.222
## site35R 3.53839 9.90860 0.357
## site36R -12.54383 7.52008 -1.668
## site37R 12.81897 8.31577 1.542
## site38R 10.03073 5.90936 1.697
## site39R 16.16269 16.75789 0.964
## site40R 30.91869 11.88854 2.601
## site41R -0.75180 9.68348 -0.078
## site42R -0.42261 5.19932 -0.081
## time_firstPFT:NO3_5yrPreCensor -1.74573 1.13553 -1.537
## time_firstPFT:site02R -14.64981 14.71042 -0.996
## time_firstPFT:site03R 1.43392 5.01351 0.286
## time_firstPFT:site04R -4.20710 5.53722 -0.760
## time_firstPFT:site05R -1.15523 6.20537 -0.186
## time_firstPFT:site06R -3.51971 4.79413 -0.734
## time_firstPFT:site07R -3.64249 1.38890 -2.623
## time_firstPFT:site09R -6.61242 4.22895 -1.564
## time_firstPFT:site101 -1.01569 1.06918 -0.950
## time_firstPFT:site102 -3.04730 2.10308 -1.449
## time_firstPFT:site103 0.76110 1.21043 0.629
## time_firstPFT:site104 5.17269 3.52918 1.466
## time_firstPFT:site105 -1.08590 1.15073 -0.944
## time_firstPFT:site106 1.88169 1.57306 1.196
## time_firstPFT:site107 6.85329 6.70004 1.023
## time_firstPFT:site108 5.26675 3.14864 1.673
## time_firstPFT:site11R 1.87509 2.82336 0.664
## time_firstPFT:site12R -0.77508 4.09064 -0.189
## time_firstPFT:site13R -2.30527 4.02983 -0.572
## time_firstPFT:site14R 3.26036 18.88990 0.173
## time_firstPFT:site15R -4.27705 11.38059 -0.376
## time_firstPFT:site16R 2.08583 2.62285 0.795
## time_firstPFT:site18R 5.66400 10.76931 0.526
## time_firstPFT:site19R 1.83956 4.29183 0.429
## time_firstPFT:site20R 0.20729 3.16050 0.066
## time_firstPFT:site21R 3.56019 4.52725 0.786
## time_firstPFT:site22R -3.74821 2.65313 -1.413
## time_firstPFT:site23R 0.20250 5.05316 0.040
## time_firstPFT:site24R 0.03636 2.30398 0.016
## time_firstPFT:site25R -6.53913 2.70148 -2.421
## time_firstPFT:site28R -11.51496 10.93925 -1.053
## time_firstPFT:site29R -1.34554 4.72987 -0.284
## time_firstPFT:site31R -0.31928 2.04245 -0.156
## time_firstPFT:site32R -4.85973 3.30604 -1.470
## time_firstPFT:site33R 1.91188 3.88868 0.492
## time_firstPFT:site34R -1.11403 2.35005 -0.474
## time_firstPFT:site35R 10.56127 4.19031 2.520
## time_firstPFT:site36R 3.31128 2.81960 1.174
## time_firstPFT:site37R -2.28305 2.72452 -0.838
## time_firstPFT:site38R -4.15517 1.96429 -2.115
## time_firstPFT:site39R -47.31082 8.56632 -5.523
## time_firstPFT:site40R -0.75881 4.44977 -0.171
## time_firstPFT:site41R 1.25458 5.51318 0.228
## time_firstPFT:site42R 1.20053 5.37143 0.224##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.923
## Unadjusted ICC: 0.740report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NO3_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 63.51 (95% CI [57.35,
## 69.68], t(2068) = 20.20, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.25, 95% CI [-4.82, 0.32], t(2068) = -1.72, p = 0.086; Std. beta =
## -0.41, 95% CI [-0.52, -0.30])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.59, 95% CI [-8.67, 1.49], t(2068) = -1.38, p = 0.166; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-39.94, 26.06], t(2068) = -0.41, p = 0.680; Std. beta = -1.72,
## 95% CI [-4.51, 1.07])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.35, 95% CI [-10.30, 37.01], t(2068) = 1.11, p = 0.268; Std. beta = 0.92,
## 95% CI [-0.49, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.43, 95% CI [-17.82, 28.68], t(2068) = 0.46, p = 0.647; Std. beta = -0.05,
## 95% CI [-1.57, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.74, 95% CI [-30.79, 7.32], t(2068) = -1.21, p = 0.227; Std. beta = -0.80,
## 95% CI [-2.17, 0.58])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-4.28, 42.64], t(2068) = 1.60, p = 0.109; Std. beta = 0.82,
## 95% CI [-0.67, 2.31])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.36, 95% CI [4.04, 22.67], t(2068) = 2.81, p = 0.005; Std. beta = 0.46, 95%
## CI [-0.09, 1.02])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.55, 95% CI [-2.69, 43.79], t(2068) = 1.73, p = 0.083; Std. beta = 0.62,
## 95% CI [-0.83, 2.08])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-4.00, 8.81], t(2068) = 0.74, p = 0.461; Std. beta = 0.05, 95%
## CI [-0.34, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.34, 95% CI [-3.28, 21.97], t(2068) = 1.45, p = 0.147; Std. beta = 0.28, 95%
## CI [-0.48, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.55, 95% CI [-10.03, 2.92], t(2068) = -1.08, p = 0.282; Std. beta = -0.14,
## 95% CI [-0.55, 0.26])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.63, 95% CI [-22.02, 4.75], t(2068) = -1.26, p = 0.206; Std. beta = -0.05,
## 95% CI [-0.97, 0.87])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.63, 9.56], t(2068) = 0.88, p = 0.379; Std. beta = 0.08, 95%
## CI [-0.33, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-12.02, 4.37], t(2068) = -0.91, p = 0.361; Std. beta = -0.06,
## 95% CI [-0.56, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.53, 95% CI [-29.99, 16.94], t(2068) = -0.55, p = 0.585; Std. beta = 0.23,
## 95% CI [-1.35, 1.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.46, 95% CI [-21.64, 16.71], t(2068) = -0.25, p = 0.801; Std. beta = 0.32,
## 95% CI [-0.82, 1.47])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.64, 95% CI [-24.50, 43.79], t(2068) = 0.55, p = 0.580; Std. beta = 0.57,
## 95% CI [-1.45, 2.58])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 11.55, 95% CI [-3.46, 26.56], t(2068) = 1.51, p = 0.132; Std. beta = 0.85,
## 95% CI [-0.09, 1.79])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.53, 95% CI [-12.65, 33.70], t(2068) = 0.89, p = 0.373; Std. beta = 0.55,
## 95% CI [-0.90, 2.00])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.83, 95% CI [-2.61, 32.27], t(2068) = 1.67, p = 0.096; Std. beta = 0.67,
## 95% CI [-0.39, 1.73])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.19, 95% CI [-23.19, 35.56], t(2068) = 0.41, p = 0.680; Std. beta = 0.66,
## 95% CI [-1.95, 3.26])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -30.43, 95% CI [-63.70, 2.84], t(2068) = -1.79, p = 0.073; Std. beta = -2.18,
## 95% CI [-4.56, 0.21])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.11, 95% CI [-29.80, -0.42], t(2068) = -2.02, p = 0.044; Std. beta = -0.71,
## 95% CI [-1.62, 0.21])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.42, 95% CI [-27.62, 38.46], t(2068) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.63, 2.27])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.77, 95% CI [-25.39, 21.86], t(2068) = -0.15, p = 0.883; Std. beta = 0.40,
## 95% CI [-1.72, 2.52])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-10.64, 20.68], t(2068) = 0.63, p = 0.530; Std. beta = 0.46,
## 95% CI [-0.61, 1.53])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-10.78, 16.54], t(2068) = 0.41, p = 0.679; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.29, 95% CI [-29.97, 34.54], t(2068) = 0.14, p = 0.889; Std. beta = 0.45,
## 95% CI [-1.46, 2.36])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-8.44, 12.25], t(2068) = 0.36, p = 0.718; Std. beta = -0.22,
## 95% CI [-0.90, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-27.64, 2.69], t(2068) = -1.61, p = 0.107; Std. beta = -0.72,
## 95% CI [-1.87, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-6.10, 18.94], t(2068) = 1.01, p = 0.315; Std. beta = 0.38, 95%
## CI [-0.38, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-11.17, 16.11], t(2068) = 0.35, p = 0.723; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 1.07, 95% CI [-18.12, 20.25], t(2068) = 0.11, p = 0.913; Std. beta = -0.96,
## 95% CI [-3.03, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.34, 95% CI [-38.12, 27.45], t(2068) = -0.32, p = 0.750; Std. beta = -0.43,
## 95% CI [-2.35, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-12.87, 16.91], t(2068) = 0.27, p = 0.790; Std. beta = 0.09,
## 95% CI [-0.79, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-7.08, 26.51], t(2068) = 1.13, p = 0.257; Std. beta = 0.14, 95%
## CI [-0.91, 1.19])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.58, 95% CI [-34.21, -0.95], t(2068) = -2.07, p = 0.038; Std. beta = -0.87,
## 95% CI [-1.97, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.42, 95% CI [-11.16, 14.01], t(2068) = 0.22, p = 0.824; Std. beta = -0.02,
## 95% CI [-0.79, 0.76])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-15.89, 22.97], t(2068) = 0.36, p = 0.721; Std. beta = 1.15,
## 95% CI [-0.07, 2.37])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.54, 95% CI [-27.29, 2.20], t(2068) = -1.67, p = 0.095; Std. beta = -0.44,
## 95% CI [-1.37, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.82, 95% CI [-3.49, 29.13], t(2068) = 1.54, p = 0.123; Std. beta = 0.55,
## 95% CI [-0.43, 1.54])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-1.56, 21.62], t(2068) = 1.70, p = 0.090; Std. beta = 0.22,
## 95% CI [-0.48, 0.93])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.16, 95% CI [-16.70, 49.03], t(2068) = 0.96, p = 0.335; Std. beta = -3.26,
## 95% CI [-5.42, -1.11])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.92, 95% CI [7.60, 54.23], t(2068) = 2.60, p = 0.009; Std. beta = 1.76, 95%
## CI [0.27, 3.24])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.75, 95% CI [-19.74, 18.24], t(2068) = -0.08, p = 0.938; Std. beta = 0.07,
## 95% CI [-1.24, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.42, 95% CI [-10.62, 9.77], t(2068) = -0.08, p = 0.935; Std. beta = 0.08,
## 95% CI [-0.87, 1.04])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -1.75, 95% CI [-3.97, 0.48], t(2068) =
## -1.54, p = 0.124; Std. beta = -0.07, 95% CI [-0.16, 0.02])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.65, 95% CI [-43.50, 14.20], t(2068) = -1.00, p = 0.319;
## Std. beta = -1.57, 95% CI [-4.67, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-8.40, 11.27], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.15, 95% CI [-0.90, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-15.07, 6.65], t(2068) = -0.76, p = 0.447; Std.
## beta = -0.45, 95% CI [-1.62, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.16, 95% CI [-13.32, 11.01], t(2068) = -0.19, p = 0.852;
## Std. beta = -0.12, 95% CI [-1.43, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-12.92, 5.88], t(2068) = -0.73, p = 0.463; Std.
## beta = -0.38, 95% CI [-1.39, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.64, 95% CI [-6.37, -0.92], t(2068) = -2.62, p = 0.009; Std.
## beta = -0.39, 95% CI [-0.68, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-14.91, 1.68], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.02, 95% CI [-3.11, 1.08], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.11, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.17, 1.08], t(2068) = -1.45, p = 0.147; Std.
## beta = -0.33, 95% CI [-0.77, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.76, 95% CI [-1.61, 3.13], t(2068) = 0.63, p = 0.530; Std.
## beta = 0.08, 95% CI [-0.17, 0.34])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.17, 95% CI [-1.75, 12.09], t(2068) = 1.47, p = 0.143; Std.
## beta = 0.56, 95% CI [-0.19, 1.30])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-3.34, 1.17], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.12, 95% CI [-0.36, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-1.20, 4.97], t(2068) = 1.20, p = 0.232; Std.
## beta = 0.20, 95% CI [-0.13, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.85, 95% CI [-6.29, 19.99], t(2068) = 1.02, p = 0.306; Std.
## beta = 0.74, 95% CI [-0.68, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.91, 11.44], t(2068) = 1.67, p = 0.095; Std.
## beta = 0.57, 95% CI [-0.10, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-3.66, 7.41], t(2068) = 0.66, p = 0.507; Std.
## beta = 0.20, 95% CI [-0.39, 0.80])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-8.80, 7.25], t(2068) = -0.19, p = 0.850; Std.
## beta = -0.08, 95% CI [-0.95, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-10.21, 5.60], t(2068) = -0.57, p = 0.567; Std.
## beta = -0.25, 95% CI [-1.10, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.78, 40.31], t(2068) = 0.17, p = 0.863; Std.
## beta = 0.35, 95% CI [-3.63, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-26.60, 18.04], t(2068) = -0.38, p = 0.707;
## Std. beta = -0.46, 95% CI [-2.86, 1.94])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-3.06, 7.23], t(2068) = 0.80, p = 0.427; Std.
## beta = 0.22, 95% CI [-0.33, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.66, 95% CI [-15.46, 26.78], t(2068) = 0.53, p = 0.599; Std.
## beta = 0.61, 95% CI [-1.66, 2.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-6.58, 10.26], t(2068) = 0.43, p = 0.668; Std.
## beta = 0.20, 95% CI [-0.71, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-5.99, 6.41], t(2068) = 0.07, p = 0.948; Std.
## beta = 0.02, 95% CI [-0.64, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.56, 95% CI [-5.32, 12.44], t(2068) = 0.79, p = 0.432; Std.
## beta = 0.38, 95% CI [-0.57, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.75, 95% CI [-8.95, 1.45], t(2068) = -1.41, p = 0.158; Std.
## beta = -0.40, 95% CI [-0.96, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-9.71, 10.11], t(2068) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-1.04, 1.09])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.48, 4.55], t(2068) = 0.02, p = 0.987; Std.
## beta = 3.90e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.54, 95% CI [-11.84, -1.24], t(2068) = -2.42, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-32.97, 9.94], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.54, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-10.62, 7.93], t(2068) = -0.28, p = 0.776; Std.
## beta = -0.14, 95% CI [-1.14, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.32, 3.69], t(2068) = -0.16, p = 0.876; Std.
## beta = -0.03, 95% CI [-0.46, 0.40])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-11.34, 1.62], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.52, 95% CI [-1.22, 0.17])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.91, 95% CI [-5.71, 9.54], t(2068) = 0.49, p = 0.623; Std.
## beta = 0.21, 95% CI [-0.61, 1.02])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-5.72, 3.49], t(2068) = -0.47, p = 0.636; Std.
## beta = -0.12, 95% CI [-0.61, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [2.34, 18.78], t(2068) = 2.52, p = 0.012; Std.
## beta = 1.13, 95% CI [0.25, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.22, 8.84], t(2068) = 1.17, p = 0.240; Std.
## beta = 0.36, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-7.63, 3.06], t(2068) = -0.84, p = 0.402; Std.
## beta = -0.25, 95% CI [-0.82, 0.33])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.16, 95% CI [-8.01, -0.30], t(2068) = -2.12, p = 0.035; Std.
## beta = -0.45, 95% CI [-0.86, -0.03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.31, 95% CI [-64.11, -30.51], t(2068) = -5.52, p < .001;
## Std. beta = -5.08, 95% CI [-6.89, -3.28])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.49, 7.97], t(2068) = -0.17, p = 0.865; Std.
## beta = -0.08, 95% CI [-1.02, 0.86])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-9.56, 12.07], t(2068) = 0.23, p = 0.820; Std.
## beta = 0.13, 95% CI [-1.03, 1.30])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.33, 11.73], t(2068) = 0.22, p = 0.823; Std.
## beta = 0.13, 95% CI [-1.00, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NO3_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to NO3_5yrPreCensor = 0, is at 63.51 (95% CI [57.35, 69.68],
## t(2068) = 20.20, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.25, 95% CI [-4.82, 0.32], t(2068) = -1.72, p = 0.086; Std. beta =
## -0.41, 95% CI [-0.52, -0.30])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.59, 95% CI [-8.67, 1.49], t(2068) = -1.38, p = 0.166; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-39.94, 26.06], t(2068) = -0.41, p = 0.680; Std. beta = -1.72,
## 95% CI [-4.51, 1.07])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.35, 95% CI [-10.30, 37.01], t(2068) = 1.11, p = 0.268; Std. beta = 0.92,
## 95% CI [-0.49, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.43, 95% CI [-17.82, 28.68], t(2068) = 0.46, p = 0.647; Std. beta = -0.05,
## 95% CI [-1.57, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.74, 95% CI [-30.79, 7.32], t(2068) = -1.21, p = 0.227; Std. beta = -0.80,
## 95% CI [-2.17, 0.58])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-4.28, 42.64], t(2068) = 1.60, p = 0.109; Std. beta = 0.82,
## 95% CI [-0.67, 2.31])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.36, 95% CI [4.04, 22.67], t(2068) = 2.81, p = 0.005; Std. beta = 0.46, 95%
## CI [-0.09, 1.02])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.55, 95% CI [-2.69, 43.79], t(2068) = 1.73, p = 0.083; Std. beta = 0.62,
## 95% CI [-0.83, 2.08])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-4.00, 8.81], t(2068) = 0.74, p = 0.461; Std. beta = 0.05, 95%
## CI [-0.34, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.34, 95% CI [-3.28, 21.97], t(2068) = 1.45, p = 0.147; Std. beta = 0.28, 95%
## CI [-0.48, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.55, 95% CI [-10.03, 2.92], t(2068) = -1.08, p = 0.282; Std. beta = -0.14,
## 95% CI [-0.55, 0.26])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.63, 95% CI [-22.02, 4.75], t(2068) = -1.26, p = 0.206; Std. beta = -0.05,
## 95% CI [-0.97, 0.87])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.63, 9.56], t(2068) = 0.88, p = 0.379; Std. beta = 0.08, 95%
## CI [-0.33, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-12.02, 4.37], t(2068) = -0.91, p = 0.361; Std. beta = -0.06,
## 95% CI [-0.56, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.53, 95% CI [-29.99, 16.94], t(2068) = -0.55, p = 0.585; Std. beta = 0.23,
## 95% CI [-1.35, 1.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.46, 95% CI [-21.64, 16.71], t(2068) = -0.25, p = 0.801; Std. beta = 0.32,
## 95% CI [-0.82, 1.47])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.64, 95% CI [-24.50, 43.79], t(2068) = 0.55, p = 0.580; Std. beta = 0.57,
## 95% CI [-1.45, 2.58])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 11.55, 95% CI [-3.46, 26.56], t(2068) = 1.51, p = 0.132; Std. beta = 0.85,
## 95% CI [-0.09, 1.79])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.53, 95% CI [-12.65, 33.70], t(2068) = 0.89, p = 0.373; Std. beta = 0.55,
## 95% CI [-0.90, 2.00])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.83, 95% CI [-2.61, 32.27], t(2068) = 1.67, p = 0.096; Std. beta = 0.67,
## 95% CI [-0.39, 1.73])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.19, 95% CI [-23.19, 35.56], t(2068) = 0.41, p = 0.680; Std. beta = 0.66,
## 95% CI [-1.95, 3.26])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -30.43, 95% CI [-63.70, 2.84], t(2068) = -1.79, p = 0.073; Std. beta = -2.18,
## 95% CI [-4.56, 0.21])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.11, 95% CI [-29.80, -0.42], t(2068) = -2.02, p = 0.044; Std. beta = -0.71,
## 95% CI [-1.62, 0.21])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.42, 95% CI [-27.62, 38.46], t(2068) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.63, 2.27])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.77, 95% CI [-25.39, 21.86], t(2068) = -0.15, p = 0.883; Std. beta = 0.40,
## 95% CI [-1.72, 2.52])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-10.64, 20.68], t(2068) = 0.63, p = 0.530; Std. beta = 0.46,
## 95% CI [-0.61, 1.53])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-10.78, 16.54], t(2068) = 0.41, p = 0.679; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.29, 95% CI [-29.97, 34.54], t(2068) = 0.14, p = 0.889; Std. beta = 0.45,
## 95% CI [-1.46, 2.36])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-8.44, 12.25], t(2068) = 0.36, p = 0.718; Std. beta = -0.22,
## 95% CI [-0.90, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-27.64, 2.69], t(2068) = -1.61, p = 0.107; Std. beta = -0.72,
## 95% CI [-1.87, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-6.10, 18.94], t(2068) = 1.01, p = 0.315; Std. beta = 0.38, 95%
## CI [-0.38, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-11.17, 16.11], t(2068) = 0.35, p = 0.723; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 1.07, 95% CI [-18.12, 20.25], t(2068) = 0.11, p = 0.913; Std. beta = -0.96,
## 95% CI [-3.03, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.34, 95% CI [-38.12, 27.45], t(2068) = -0.32, p = 0.750; Std. beta = -0.43,
## 95% CI [-2.35, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-12.87, 16.91], t(2068) = 0.27, p = 0.790; Std. beta = 0.09,
## 95% CI [-0.79, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-7.08, 26.51], t(2068) = 1.13, p = 0.257; Std. beta = 0.14, 95%
## CI [-0.91, 1.19])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.58, 95% CI [-34.21, -0.95], t(2068) = -2.07, p = 0.038; Std. beta = -0.87,
## 95% CI [-1.97, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.42, 95% CI [-11.16, 14.01], t(2068) = 0.22, p = 0.824; Std. beta = -0.02,
## 95% CI [-0.79, 0.76])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-15.89, 22.97], t(2068) = 0.36, p = 0.721; Std. beta = 1.15,
## 95% CI [-0.07, 2.37])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.54, 95% CI [-27.29, 2.20], t(2068) = -1.67, p = 0.095; Std. beta = -0.44,
## 95% CI [-1.37, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.82, 95% CI [-3.49, 29.13], t(2068) = 1.54, p = 0.123; Std. beta = 0.55,
## 95% CI [-0.43, 1.54])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-1.56, 21.62], t(2068) = 1.70, p = 0.090; Std. beta = 0.22,
## 95% CI [-0.48, 0.93])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.16, 95% CI [-16.70, 49.03], t(2068) = 0.96, p = 0.335; Std. beta = -3.26,
## 95% CI [-5.42, -1.11])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.92, 95% CI [7.60, 54.23], t(2068) = 2.60, p = 0.009; Std. beta = 1.76, 95%
## CI [0.27, 3.24])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.75, 95% CI [-19.74, 18.24], t(2068) = -0.08, p = 0.938; Std. beta = 0.07,
## 95% CI [-1.24, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.42, 95% CI [-10.62, 9.77], t(2068) = -0.08, p = 0.935; Std. beta = 0.08,
## 95% CI [-0.87, 1.04])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -1.75, 95% CI [-3.97, 0.48], t(2068) =
## -1.54, p = 0.124; Std. beta = -0.07, 95% CI [-0.16, 0.02])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.65, 95% CI [-43.50, 14.20], t(2068) = -1.00, p = 0.319;
## Std. beta = -1.57, 95% CI [-4.67, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-8.40, 11.27], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.15, 95% CI [-0.90, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-15.07, 6.65], t(2068) = -0.76, p = 0.447; Std.
## beta = -0.45, 95% CI [-1.62, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.16, 95% CI [-13.32, 11.01], t(2068) = -0.19, p = 0.852;
## Std. beta = -0.12, 95% CI [-1.43, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-12.92, 5.88], t(2068) = -0.73, p = 0.463; Std.
## beta = -0.38, 95% CI [-1.39, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.64, 95% CI [-6.37, -0.92], t(2068) = -2.62, p = 0.009; Std.
## beta = -0.39, 95% CI [-0.68, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-14.91, 1.68], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.02, 95% CI [-3.11, 1.08], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.11, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.17, 1.08], t(2068) = -1.45, p = 0.147; Std.
## beta = -0.33, 95% CI [-0.77, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.76, 95% CI [-1.61, 3.13], t(2068) = 0.63, p = 0.530; Std.
## beta = 0.08, 95% CI [-0.17, 0.34])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.17, 95% CI [-1.75, 12.09], t(2068) = 1.47, p = 0.143; Std.
## beta = 0.56, 95% CI [-0.19, 1.30])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-3.34, 1.17], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.12, 95% CI [-0.36, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-1.20, 4.97], t(2068) = 1.20, p = 0.232; Std.
## beta = 0.20, 95% CI [-0.13, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.85, 95% CI [-6.29, 19.99], t(2068) = 1.02, p = 0.306; Std.
## beta = 0.74, 95% CI [-0.68, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.91, 11.44], t(2068) = 1.67, p = 0.095; Std.
## beta = 0.57, 95% CI [-0.10, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-3.66, 7.41], t(2068) = 0.66, p = 0.507; Std.
## beta = 0.20, 95% CI [-0.39, 0.80])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-8.80, 7.25], t(2068) = -0.19, p = 0.850; Std.
## beta = -0.08, 95% CI [-0.95, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-10.21, 5.60], t(2068) = -0.57, p = 0.567; Std.
## beta = -0.25, 95% CI [-1.10, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.78, 40.31], t(2068) = 0.17, p = 0.863; Std.
## beta = 0.35, 95% CI [-3.63, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-26.60, 18.04], t(2068) = -0.38, p = 0.707;
## Std. beta = -0.46, 95% CI [-2.86, 1.94])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-3.06, 7.23], t(2068) = 0.80, p = 0.427; Std.
## beta = 0.22, 95% CI [-0.33, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.66, 95% CI [-15.46, 26.78], t(2068) = 0.53, p = 0.599; Std.
## beta = 0.61, 95% CI [-1.66, 2.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-6.58, 10.26], t(2068) = 0.43, p = 0.668; Std.
## beta = 0.20, 95% CI [-0.71, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-5.99, 6.41], t(2068) = 0.07, p = 0.948; Std.
## beta = 0.02, 95% CI [-0.64, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.56, 95% CI [-5.32, 12.44], t(2068) = 0.79, p = 0.432; Std.
## beta = 0.38, 95% CI [-0.57, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.75, 95% CI [-8.95, 1.45], t(2068) = -1.41, p = 0.158; Std.
## beta = -0.40, 95% CI [-0.96, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-9.71, 10.11], t(2068) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-1.04, 1.09])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.48, 4.55], t(2068) = 0.02, p = 0.987; Std.
## beta = 3.90e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.54, 95% CI [-11.84, -1.24], t(2068) = -2.42, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-32.97, 9.94], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.54, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-10.62, 7.93], t(2068) = -0.28, p = 0.776; Std.
## beta = -0.14, 95% CI [-1.14, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.32, 3.69], t(2068) = -0.16, p = 0.876; Std.
## beta = -0.03, 95% CI [-0.46, 0.40])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-11.34, 1.62], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.52, 95% CI [-1.22, 0.17])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.91, 95% CI [-5.71, 9.54], t(2068) = 0.49, p = 0.623; Std.
## beta = 0.21, 95% CI [-0.61, 1.02])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-5.72, 3.49], t(2068) = -0.47, p = 0.636; Std.
## beta = -0.12, 95% CI [-0.61, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [2.34, 18.78], t(2068) = 2.52, p = 0.012; Std.
## beta = 1.13, 95% CI [0.25, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.22, 8.84], t(2068) = 1.17, p = 0.240; Std.
## beta = 0.36, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-7.63, 3.06], t(2068) = -0.84, p = 0.402; Std.
## beta = -0.25, 95% CI [-0.82, 0.33])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.16, 95% CI [-8.01, -0.30], t(2068) = -2.12, p = 0.035; Std.
## beta = -0.45, 95% CI [-0.86, -0.03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.31, 95% CI [-64.11, -30.51], t(2068) = -5.52, p < .001;
## Std. beta = -5.08, 95% CI [-6.89, -3.28])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.49, 7.97], t(2068) = -0.17, p = 0.865; Std.
## beta = -0.08, 95% CI [-1.02, 0.86])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-9.56, 12.07], t(2068) = 0.23, p = 0.820; Std.
## beta = 0.13, 95% CI [-1.03, 1.30])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.33, 11.73], t(2068) = 0.22, p = 0.823; Std.
## beta = 0.13, 95% CI [-1.00, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 63.51 (95% CI [57.35, 69.68], t(2068) = 20.20, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.25, 95% CI [-4.82, 0.32], t(2068) = -1.72, p = 0.086; Std. beta =
## -0.41, 95% CI [-0.52, -0.30])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.59, 95% CI [-8.67, 1.49], t(2068) = -1.38, p = 0.166; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-39.94, 26.06], t(2068) = -0.41, p = 0.680; Std. beta = -1.72,
## 95% CI [-4.51, 1.07])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.35, 95% CI [-10.30, 37.01], t(2068) = 1.11, p = 0.268; Std. beta = 0.92,
## 95% CI [-0.49, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.43, 95% CI [-17.82, 28.68], t(2068) = 0.46, p = 0.647; Std. beta = -0.05,
## 95% CI [-1.57, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.74, 95% CI [-30.79, 7.32], t(2068) = -1.21, p = 0.227; Std. beta = -0.80,
## 95% CI [-2.17, 0.58])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-4.28, 42.64], t(2068) = 1.60, p = 0.109; Std. beta = 0.82,
## 95% CI [-0.67, 2.31])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.36, 95% CI [4.04, 22.67], t(2068) = 2.81, p = 0.005; Std. beta = 0.46, 95%
## CI [-0.09, 1.02])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.55, 95% CI [-2.69, 43.79], t(2068) = 1.73, p = 0.083; Std. beta = 0.62,
## 95% CI [-0.83, 2.08])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-4.00, 8.81], t(2068) = 0.74, p = 0.461; Std. beta = 0.05, 95%
## CI [-0.34, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.34, 95% CI [-3.28, 21.97], t(2068) = 1.45, p = 0.147; Std. beta = 0.28, 95%
## CI [-0.48, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.55, 95% CI [-10.03, 2.92], t(2068) = -1.08, p = 0.282; Std. beta = -0.14,
## 95% CI [-0.55, 0.26])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.63, 95% CI [-22.02, 4.75], t(2068) = -1.26, p = 0.206; Std. beta = -0.05,
## 95% CI [-0.97, 0.87])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.63, 9.56], t(2068) = 0.88, p = 0.379; Std. beta = 0.08, 95%
## CI [-0.33, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-12.02, 4.37], t(2068) = -0.91, p = 0.361; Std. beta = -0.06,
## 95% CI [-0.56, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.53, 95% CI [-29.99, 16.94], t(2068) = -0.55, p = 0.585; Std. beta = 0.23,
## 95% CI [-1.35, 1.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.46, 95% CI [-21.64, 16.71], t(2068) = -0.25, p = 0.801; Std. beta = 0.32,
## 95% CI [-0.82, 1.47])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.64, 95% CI [-24.50, 43.79], t(2068) = 0.55, p = 0.580; Std. beta = 0.57,
## 95% CI [-1.45, 2.58])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 11.55, 95% CI [-3.46, 26.56], t(2068) = 1.51, p = 0.132; Std. beta = 0.85,
## 95% CI [-0.09, 1.79])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.53, 95% CI [-12.65, 33.70], t(2068) = 0.89, p = 0.373; Std. beta = 0.55,
## 95% CI [-0.90, 2.00])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.83, 95% CI [-2.61, 32.27], t(2068) = 1.67, p = 0.096; Std. beta = 0.67,
## 95% CI [-0.39, 1.73])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.19, 95% CI [-23.19, 35.56], t(2068) = 0.41, p = 0.680; Std. beta = 0.66,
## 95% CI [-1.95, 3.26])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -30.43, 95% CI [-63.70, 2.84], t(2068) = -1.79, p = 0.073; Std. beta = -2.18,
## 95% CI [-4.56, 0.21])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.11, 95% CI [-29.80, -0.42], t(2068) = -2.02, p = 0.044; Std. beta = -0.71,
## 95% CI [-1.62, 0.21])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.42, 95% CI [-27.62, 38.46], t(2068) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.63, 2.27])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.77, 95% CI [-25.39, 21.86], t(2068) = -0.15, p = 0.883; Std. beta = 0.40,
## 95% CI [-1.72, 2.52])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-10.64, 20.68], t(2068) = 0.63, p = 0.530; Std. beta = 0.46,
## 95% CI [-0.61, 1.53])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-10.78, 16.54], t(2068) = 0.41, p = 0.679; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.29, 95% CI [-29.97, 34.54], t(2068) = 0.14, p = 0.889; Std. beta = 0.45,
## 95% CI [-1.46, 2.36])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-8.44, 12.25], t(2068) = 0.36, p = 0.718; Std. beta = -0.22,
## 95% CI [-0.90, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-27.64, 2.69], t(2068) = -1.61, p = 0.107; Std. beta = -0.72,
## 95% CI [-1.87, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-6.10, 18.94], t(2068) = 1.01, p = 0.315; Std. beta = 0.38, 95%
## CI [-0.38, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-11.17, 16.11], t(2068) = 0.35, p = 0.723; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 1.07, 95% CI [-18.12, 20.25], t(2068) = 0.11, p = 0.913; Std. beta = -0.96,
## 95% CI [-3.03, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.34, 95% CI [-38.12, 27.45], t(2068) = -0.32, p = 0.750; Std. beta = -0.43,
## 95% CI [-2.35, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-12.87, 16.91], t(2068) = 0.27, p = 0.790; Std. beta = 0.09,
## 95% CI [-0.79, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-7.08, 26.51], t(2068) = 1.13, p = 0.257; Std. beta = 0.14, 95%
## CI [-0.91, 1.19])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.58, 95% CI [-34.21, -0.95], t(2068) = -2.07, p = 0.038; Std. beta = -0.87,
## 95% CI [-1.97, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.42, 95% CI [-11.16, 14.01], t(2068) = 0.22, p = 0.824; Std. beta = -0.02,
## 95% CI [-0.79, 0.76])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-15.89, 22.97], t(2068) = 0.36, p = 0.721; Std. beta = 1.15,
## 95% CI [-0.07, 2.37])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.54, 95% CI [-27.29, 2.20], t(2068) = -1.67, p = 0.095; Std. beta = -0.44,
## 95% CI [-1.37, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.82, 95% CI [-3.49, 29.13], t(2068) = 1.54, p = 0.123; Std. beta = 0.55,
## 95% CI [-0.43, 1.54])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-1.56, 21.62], t(2068) = 1.70, p = 0.090; Std. beta = 0.22,
## 95% CI [-0.48, 0.93])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.16, 95% CI [-16.70, 49.03], t(2068) = 0.96, p = 0.335; Std. beta = -3.26,
## 95% CI [-5.42, -1.11])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.92, 95% CI [7.60, 54.23], t(2068) = 2.60, p = 0.009; Std. beta = 1.76, 95%
## CI [0.27, 3.24])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.75, 95% CI [-19.74, 18.24], t(2068) = -0.08, p = 0.938; Std. beta = 0.07,
## 95% CI [-1.24, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.42, 95% CI [-10.62, 9.77], t(2068) = -0.08, p = 0.935; Std. beta = 0.08,
## 95% CI [-0.87, 1.04])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -1.75, 95% CI [-3.97, 0.48], t(2068) =
## -1.54, p = 0.124; Std. beta = -0.07, 95% CI [-0.16, 0.02])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.65, 95% CI [-43.50, 14.20], t(2068) = -1.00, p = 0.319;
## Std. beta = -1.57, 95% CI [-4.67, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-8.40, 11.27], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.15, 95% CI [-0.90, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-15.07, 6.65], t(2068) = -0.76, p = 0.447; Std.
## beta = -0.45, 95% CI [-1.62, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.16, 95% CI [-13.32, 11.01], t(2068) = -0.19, p = 0.852;
## Std. beta = -0.12, 95% CI [-1.43, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-12.92, 5.88], t(2068) = -0.73, p = 0.463; Std.
## beta = -0.38, 95% CI [-1.39, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.64, 95% CI [-6.37, -0.92], t(2068) = -2.62, p = 0.009; Std.
## beta = -0.39, 95% CI [-0.68, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-14.91, 1.68], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.02, 95% CI [-3.11, 1.08], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.11, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.17, 1.08], t(2068) = -1.45, p = 0.147; Std.
## beta = -0.33, 95% CI [-0.77, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.76, 95% CI [-1.61, 3.13], t(2068) = 0.63, p = 0.530; Std.
## beta = 0.08, 95% CI [-0.17, 0.34])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.17, 95% CI [-1.75, 12.09], t(2068) = 1.47, p = 0.143; Std.
## beta = 0.56, 95% CI [-0.19, 1.30])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-3.34, 1.17], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.12, 95% CI [-0.36, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-1.20, 4.97], t(2068) = 1.20, p = 0.232; Std.
## beta = 0.20, 95% CI [-0.13, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.85, 95% CI [-6.29, 19.99], t(2068) = 1.02, p = 0.306; Std.
## beta = 0.74, 95% CI [-0.68, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.91, 11.44], t(2068) = 1.67, p = 0.095; Std.
## beta = 0.57, 95% CI [-0.10, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-3.66, 7.41], t(2068) = 0.66, p = 0.507; Std.
## beta = 0.20, 95% CI [-0.39, 0.80])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-8.80, 7.25], t(2068) = -0.19, p = 0.850; Std.
## beta = -0.08, 95% CI [-0.95, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-10.21, 5.60], t(2068) = -0.57, p = 0.567; Std.
## beta = -0.25, 95% CI [-1.10, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.78, 40.31], t(2068) = 0.17, p = 0.863; Std.
## beta = 0.35, 95% CI [-3.63, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-26.60, 18.04], t(2068) = -0.38, p = 0.707;
## Std. beta = -0.46, 95% CI [-2.86, 1.94])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-3.06, 7.23], t(2068) = 0.80, p = 0.427; Std.
## beta = 0.22, 95% CI [-0.33, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.66, 95% CI [-15.46, 26.78], t(2068) = 0.53, p = 0.599; Std.
## beta = 0.61, 95% CI [-1.66, 2.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-6.58, 10.26], t(2068) = 0.43, p = 0.668; Std.
## beta = 0.20, 95% CI [-0.71, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-5.99, 6.41], t(2068) = 0.07, p = 0.948; Std.
## beta = 0.02, 95% CI [-0.64, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.56, 95% CI [-5.32, 12.44], t(2068) = 0.79, p = 0.432; Std.
## beta = 0.38, 95% CI [-0.57, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.75, 95% CI [-8.95, 1.45], t(2068) = -1.41, p = 0.158; Std.
## beta = -0.40, 95% CI [-0.96, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-9.71, 10.11], t(2068) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-1.04, 1.09])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.48, 4.55], t(2068) = 0.02, p = 0.987; Std.
## beta = 3.90e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.54, 95% CI [-11.84, -1.24], t(2068) = -2.42, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-32.97, 9.94], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.54, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-10.62, 7.93], t(2068) = -0.28, p = 0.776; Std.
## beta = -0.14, 95% CI [-1.14, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.32, 3.69], t(2068) = -0.16, p = 0.876; Std.
## beta = -0.03, 95% CI [-0.46, 0.40])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-11.34, 1.62], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.52, 95% CI [-1.22, 0.17])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.91, 95% CI [-5.71, 9.54], t(2068) = 0.49, p = 0.623; Std.
## beta = 0.21, 95% CI [-0.61, 1.02])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-5.72, 3.49], t(2068) = -0.47, p = 0.636; Std.
## beta = -0.12, 95% CI [-0.61, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [2.34, 18.78], t(2068) = 2.52, p = 0.012; Std.
## beta = 1.13, 95% CI [0.25, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.22, 8.84], t(2068) = 1.17, p = 0.240; Std.
## beta = 0.36, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-7.63, 3.06], t(2068) = -0.84, p = 0.402; Std.
## beta = -0.25, 95% CI [-0.82, 0.33])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.16, 95% CI [-8.01, -0.30], t(2068) = -2.12, p = 0.035; Std.
## beta = -0.45, 95% CI [-0.86, -0.03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.31, 95% CI [-64.11, -30.51], t(2068) = -5.52, p < .001;
## Std. beta = -5.08, 95% CI [-6.89, -3.28])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.49, 7.97], t(2068) = -0.17, p = 0.865; Std.
## beta = -0.08, 95% CI [-1.02, 0.86])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-9.56, 12.07], t(2068) = 0.23, p = 0.820; Std.
## beta = 0.13, 95% CI [-1.03, 1.30])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.33, 11.73], t(2068) = 0.22, p = 0.823; Std.
## beta = 0.13, 95% CI [-1.00, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to cohort = CARE-PF, is at 63.51 (95% CI [57.35, 69.68], t(2068)
## = 20.20, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.25, 95% CI [-4.82, 0.32], t(2068) = -1.72, p = 0.086; Std. beta =
## -0.41, 95% CI [-0.52, -0.30])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.59, 95% CI [-8.67, 1.49], t(2068) = -1.38, p = 0.166; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-39.94, 26.06], t(2068) = -0.41, p = 0.680; Std. beta = -1.72,
## 95% CI [-4.51, 1.07])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.35, 95% CI [-10.30, 37.01], t(2068) = 1.11, p = 0.268; Std. beta = 0.92,
## 95% CI [-0.49, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 5.43, 95% CI [-17.82, 28.68], t(2068) = 0.46, p = 0.647; Std. beta = -0.05,
## 95% CI [-1.57, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.74, 95% CI [-30.79, 7.32], t(2068) = -1.21, p = 0.227; Std. beta = -0.80,
## 95% CI [-2.17, 0.58])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.18, 95% CI [-4.28, 42.64], t(2068) = 1.60, p = 0.109; Std. beta = 0.82,
## 95% CI [-0.67, 2.31])
## - The effect of site [07R] is statistically significant and positive (beta =
## 13.36, 95% CI [4.04, 22.67], t(2068) = 2.81, p = 0.005; Std. beta = 0.46, 95%
## CI [-0.09, 1.02])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.55, 95% CI [-2.69, 43.79], t(2068) = 1.73, p = 0.083; Std. beta = 0.62,
## 95% CI [-0.83, 2.08])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.41, 95% CI [-4.00, 8.81], t(2068) = 0.74, p = 0.461; Std. beta = 0.05, 95%
## CI [-0.34, 0.44])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.34, 95% CI [-3.28, 21.97], t(2068) = 1.45, p = 0.147; Std. beta = 0.28, 95%
## CI [-0.48, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.55, 95% CI [-10.03, 2.92], t(2068) = -1.08, p = 0.282; Std. beta = -0.14,
## 95% CI [-0.55, 0.26])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.63, 95% CI [-22.02, 4.75], t(2068) = -1.26, p = 0.206; Std. beta = -0.05,
## 95% CI [-0.97, 0.87])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.63, 9.56], t(2068) = 0.88, p = 0.379; Std. beta = 0.08, 95%
## CI [-0.33, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-12.02, 4.37], t(2068) = -0.91, p = 0.361; Std. beta = -0.06,
## 95% CI [-0.56, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -6.53, 95% CI [-29.99, 16.94], t(2068) = -0.55, p = 0.585; Std. beta = 0.23,
## 95% CI [-1.35, 1.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.46, 95% CI [-21.64, 16.71], t(2068) = -0.25, p = 0.801; Std. beta = 0.32,
## 95% CI [-0.82, 1.47])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.64, 95% CI [-24.50, 43.79], t(2068) = 0.55, p = 0.580; Std. beta = 0.57,
## 95% CI [-1.45, 2.58])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 11.55, 95% CI [-3.46, 26.56], t(2068) = 1.51, p = 0.132; Std. beta = 0.85,
## 95% CI [-0.09, 1.79])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 10.53, 95% CI [-12.65, 33.70], t(2068) = 0.89, p = 0.373; Std. beta = 0.55,
## 95% CI [-0.90, 2.00])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 14.83, 95% CI [-2.61, 32.27], t(2068) = 1.67, p = 0.096; Std. beta = 0.67,
## 95% CI [-0.39, 1.73])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.19, 95% CI [-23.19, 35.56], t(2068) = 0.41, p = 0.680; Std. beta = 0.66,
## 95% CI [-1.95, 3.26])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -30.43, 95% CI [-63.70, 2.84], t(2068) = -1.79, p = 0.073; Std. beta = -2.18,
## 95% CI [-4.56, 0.21])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.11, 95% CI [-29.80, -0.42], t(2068) = -2.02, p = 0.044; Std. beta = -0.71,
## 95% CI [-1.62, 0.21])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.42, 95% CI [-27.62, 38.46], t(2068) = 0.32, p = 0.748; Std. beta = 0.32,
## 95% CI [-1.63, 2.27])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.77, 95% CI [-25.39, 21.86], t(2068) = -0.15, p = 0.883; Std. beta = 0.40,
## 95% CI [-1.72, 2.52])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-10.64, 20.68], t(2068) = 0.63, p = 0.530; Std. beta = 0.46,
## 95% CI [-0.61, 1.53])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-10.78, 16.54], t(2068) = 0.41, p = 0.679; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.29, 95% CI [-29.97, 34.54], t(2068) = 0.14, p = 0.889; Std. beta = 0.45,
## 95% CI [-1.46, 2.36])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-8.44, 12.25], t(2068) = 0.36, p = 0.718; Std. beta = -0.22,
## 95% CI [-0.90, 0.46])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.47, 95% CI [-27.64, 2.69], t(2068) = -1.61, p = 0.107; Std. beta = -0.72,
## 95% CI [-1.87, 0.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.42, 95% CI [-6.10, 18.94], t(2068) = 1.01, p = 0.315; Std. beta = 0.38, 95%
## CI [-0.38, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-11.17, 16.11], t(2068) = 0.35, p = 0.723; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 1.07, 95% CI [-18.12, 20.25], t(2068) = 0.11, p = 0.913; Std. beta = -0.96,
## 95% CI [-3.03, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.34, 95% CI [-38.12, 27.45], t(2068) = -0.32, p = 0.750; Std. beta = -0.43,
## 95% CI [-2.35, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-12.87, 16.91], t(2068) = 0.27, p = 0.790; Std. beta = 0.09,
## 95% CI [-0.79, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.72, 95% CI [-7.08, 26.51], t(2068) = 1.13, p = 0.257; Std. beta = 0.14, 95%
## CI [-0.91, 1.19])
## - The effect of site [33R] is statistically significant and negative (beta =
## -17.58, 95% CI [-34.21, -0.95], t(2068) = -2.07, p = 0.038; Std. beta = -0.87,
## 95% CI [-1.97, 0.24])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 1.42, 95% CI [-11.16, 14.01], t(2068) = 0.22, p = 0.824; Std. beta = -0.02,
## 95% CI [-0.79, 0.76])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-15.89, 22.97], t(2068) = 0.36, p = 0.721; Std. beta = 1.15,
## 95% CI [-0.07, 2.37])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.54, 95% CI [-27.29, 2.20], t(2068) = -1.67, p = 0.095; Std. beta = -0.44,
## 95% CI [-1.37, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.82, 95% CI [-3.49, 29.13], t(2068) = 1.54, p = 0.123; Std. beta = 0.55,
## 95% CI [-0.43, 1.54])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-1.56, 21.62], t(2068) = 1.70, p = 0.090; Std. beta = 0.22,
## 95% CI [-0.48, 0.93])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.16, 95% CI [-16.70, 49.03], t(2068) = 0.96, p = 0.335; Std. beta = -3.26,
## 95% CI [-5.42, -1.11])
## - The effect of site [40R] is statistically significant and positive (beta =
## 30.92, 95% CI [7.60, 54.23], t(2068) = 2.60, p = 0.009; Std. beta = 1.76, 95%
## CI [0.27, 3.24])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.75, 95% CI [-19.74, 18.24], t(2068) = -0.08, p = 0.938; Std. beta = 0.07,
## 95% CI [-1.24, 1.37])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.42, 95% CI [-10.62, 9.77], t(2068) = -0.08, p = 0.935; Std. beta = 0.08,
## 95% CI [-0.87, 1.04])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -1.75, 95% CI [-3.97, 0.48], t(2068) =
## -1.54, p = 0.124; Std. beta = -0.07, 95% CI [-0.16, 0.02])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.65, 95% CI [-43.50, 14.20], t(2068) = -1.00, p = 0.319;
## Std. beta = -1.57, 95% CI [-4.67, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-8.40, 11.27], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.15, 95% CI [-0.90, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.21, 95% CI [-15.07, 6.65], t(2068) = -0.76, p = 0.447; Std.
## beta = -0.45, 95% CI [-1.62, 0.71])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.16, 95% CI [-13.32, 11.01], t(2068) = -0.19, p = 0.852;
## Std. beta = -0.12, 95% CI [-1.43, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-12.92, 5.88], t(2068) = -0.73, p = 0.463; Std.
## beta = -0.38, 95% CI [-1.39, 0.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.64, 95% CI [-6.37, -0.92], t(2068) = -2.62, p = 0.009; Std.
## beta = -0.39, 95% CI [-0.68, -0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.61, 95% CI [-14.91, 1.68], t(2068) = -1.56, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.02, 95% CI [-3.11, 1.08], t(2068) = -0.95, p = 0.342; Std.
## beta = -0.11, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.17, 1.08], t(2068) = -1.45, p = 0.147; Std.
## beta = -0.33, 95% CI [-0.77, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.76, 95% CI [-1.61, 3.13], t(2068) = 0.63, p = 0.530; Std.
## beta = 0.08, 95% CI [-0.17, 0.34])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.17, 95% CI [-1.75, 12.09], t(2068) = 1.47, p = 0.143; Std.
## beta = 0.56, 95% CI [-0.19, 1.30])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-3.34, 1.17], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.12, 95% CI [-0.36, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-1.20, 4.97], t(2068) = 1.20, p = 0.232; Std.
## beta = 0.20, 95% CI [-0.13, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.85, 95% CI [-6.29, 19.99], t(2068) = 1.02, p = 0.306; Std.
## beta = 0.74, 95% CI [-0.68, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.91, 11.44], t(2068) = 1.67, p = 0.095; Std.
## beta = 0.57, 95% CI [-0.10, 1.23])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-3.66, 7.41], t(2068) = 0.66, p = 0.507; Std.
## beta = 0.20, 95% CI [-0.39, 0.80])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-8.80, 7.25], t(2068) = -0.19, p = 0.850; Std.
## beta = -0.08, 95% CI [-0.95, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-10.21, 5.60], t(2068) = -0.57, p = 0.567; Std.
## beta = -0.25, 95% CI [-1.10, 0.60])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-33.78, 40.31], t(2068) = 0.17, p = 0.863; Std.
## beta = 0.35, 95% CI [-3.63, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.28, 95% CI [-26.60, 18.04], t(2068) = -0.38, p = 0.707;
## Std. beta = -0.46, 95% CI [-2.86, 1.94])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-3.06, 7.23], t(2068) = 0.80, p = 0.427; Std.
## beta = 0.22, 95% CI [-0.33, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.66, 95% CI [-15.46, 26.78], t(2068) = 0.53, p = 0.599; Std.
## beta = 0.61, 95% CI [-1.66, 2.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-6.58, 10.26], t(2068) = 0.43, p = 0.668; Std.
## beta = 0.20, 95% CI [-0.71, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-5.99, 6.41], t(2068) = 0.07, p = 0.948; Std.
## beta = 0.02, 95% CI [-0.64, 0.69])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.56, 95% CI [-5.32, 12.44], t(2068) = 0.79, p = 0.432; Std.
## beta = 0.38, 95% CI [-0.57, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.75, 95% CI [-8.95, 1.45], t(2068) = -1.41, p = 0.158; Std.
## beta = -0.40, 95% CI [-0.96, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-9.71, 10.11], t(2068) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-1.04, 1.09])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-4.48, 4.55], t(2068) = 0.02, p = 0.987; Std.
## beta = 3.90e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.54, 95% CI [-11.84, -1.24], t(2068) = -2.42, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-32.97, 9.94], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.54, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-10.62, 7.93], t(2068) = -0.28, p = 0.776; Std.
## beta = -0.14, 95% CI [-1.14, 0.85])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.32, 3.69], t(2068) = -0.16, p = 0.876; Std.
## beta = -0.03, 95% CI [-0.46, 0.40])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.86, 95% CI [-11.34, 1.62], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.52, 95% CI [-1.22, 0.17])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 1.91, 95% CI [-5.71, 9.54], t(2068) = 0.49, p = 0.623; Std.
## beta = 0.21, 95% CI [-0.61, 1.02])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-5.72, 3.49], t(2068) = -0.47, p = 0.636; Std.
## beta = -0.12, 95% CI [-0.61, 0.38])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [2.34, 18.78], t(2068) = 2.52, p = 0.012; Std.
## beta = 1.13, 95% CI [0.25, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-2.22, 8.84], t(2068) = 1.17, p = 0.240; Std.
## beta = 0.36, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-7.63, 3.06], t(2068) = -0.84, p = 0.402; Std.
## beta = -0.25, 95% CI [-0.82, 0.33])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.16, 95% CI [-8.01, -0.30], t(2068) = -2.12, p = 0.035; Std.
## beta = -0.45, 95% CI [-0.86, -0.03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.31, 95% CI [-64.11, -30.51], t(2068) = -5.52, p < .001;
## Std. beta = -5.08, 95% CI [-6.89, -3.28])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-9.49, 7.97], t(2068) = -0.17, p = 0.865; Std.
## beta = -0.08, 95% CI [-1.02, 0.86])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.25, 95% CI [-9.56, 12.07], t(2068) = 0.23, p = 0.820; Std.
## beta = 0.13, 95% CI [-1.03, 1.30])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.33, 11.73], t(2068) = 0.22, p = 0.823; Std.
## beta = 0.13, 95% CI [-1.00, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*NO3_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14366.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2985 -0.4383 -0.0210 0.4483 4.5006
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 232.95 15.263
## time_firstPFT 13.73 3.706 -0.10
## Residual 25.55 5.055
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 35.58751 6.58679 5.403
## time_firstPFT 0.84878 2.55469 0.332
## NO3_5yrPreCensor -3.27798 2.53468 -1.293
## disadv 3.78096 2.88693 1.310
## dich_RaceNon-White -6.96545 2.81361 -2.476
## sexF 4.05750 1.75522 2.312
## age_dx 0.38685 0.09106 4.248
## smokeHxFormer 3.78632 1.73263 2.185
## smokeHxAlways 18.33632 8.41310 2.179
## smokeHxUnknown -2.32313 3.93272 -0.591
## site02R -10.52916 16.19357 -0.650
## site03R 11.47125 11.70611 0.980
## site04R 4.85002 11.36884 0.427
## site05R -13.18829 9.35734 -1.409
## site06R 9.85122 16.15652 0.610
## site07R 12.15658 4.60873 2.638
## site09R 19.28524 11.40784 1.691
## site101 3.44887 3.18807 1.082
## site102 10.67712 6.25911 1.706
## site103 -3.91939 3.33808 -1.174
## site104 -10.17315 6.61851 -1.537
## site105 2.88016 3.27982 0.878
## site106 -5.68800 4.10948 -1.384
## site107 -3.69512 11.51048 -0.321
## site108 2.01008 9.84643 0.204
## site10R 6.69145 17.01557 0.393
## site11R 8.16758 7.35457 1.111
## site12R 6.02164 11.33534 0.531
## site13R 16.29653 8.61220 1.892
## site14R 5.07630 14.63043 0.347
## site15R -36.91529 16.34348 -2.259
## site16R -9.27814 7.29247 -1.272
## site17R 9.35365 16.31880 0.573
## site18R -5.36377 11.59526 -0.463
## site19R 4.74698 7.72556 0.614
## site20R 1.36891 6.70716 0.204
## site21R 1.02146 15.72420 0.065
## site22R -2.11771 5.16448 -0.410
## site23R -15.10405 8.90937 -1.695
## site24R 5.10171 6.13759 0.831
## site25R 1.33603 6.76414 0.198
## site28R 4.32440 9.44736 0.458
## site29R -7.84860 16.08040 -0.488
## site31R 3.19824 7.38908 0.433
## site32R 7.04914 8.27699 0.852
## site33R -15.90240 8.16878 -1.947
## site34R -1.06884 6.16824 -0.173
## site35R -2.85338 9.56144 -0.298
## site36R -11.55157 7.24604 -1.594
## site37R 15.39964 8.07794 1.906
## site38R 9.97003 5.69061 1.752
## site39R 20.88356 16.39073 1.274
## site40R 27.91077 11.44382 2.439
## site41R -3.26866 9.36115 -0.349
## site42R -1.09833 5.07230 -0.217
## time_firstPFT:NO3_5yrPreCensor -1.99798 1.19674 -1.670
## time_firstPFT:disadv 0.00685 1.10758 0.006
## time_firstPFT:dich_RaceNon-White 0.45790 1.13537 0.403
## time_firstPFT:sexF 0.13754 0.66678 0.206
## time_firstPFT:age_dx -0.06117 0.03477 -1.759
## time_firstPFT:smokeHxFormer 0.55212 0.67560 0.817
## time_firstPFT:smokeHxAlways 1.14283 5.29778 0.216
## time_firstPFT:smokeHxUnknown 1.88026 1.69442 1.110
## time_firstPFT:site02R -13.68331 14.75811 -0.927
## time_firstPFT:site03R 2.84021 5.09541 0.557
## time_firstPFT:site04R -3.53126 5.63091 -0.627
## time_firstPFT:site05R -0.89262 6.24940 -0.143
## time_firstPFT:site07R -2.95928 1.46653 -2.018
## time_firstPFT:site09R -6.34154 4.32745 -1.465
## time_firstPFT:site101 -0.83368 1.10576 -0.754
## time_firstPFT:site102 -3.13762 2.16594 -1.449
## time_firstPFT:site103 0.75470 1.30994 0.576
## time_firstPFT:site104 5.44950 3.62993 1.501
## time_firstPFT:site105 -1.07268 1.18124 -0.908
## time_firstPFT:site106 2.54792 1.64065 1.553
## time_firstPFT:site107 6.96980 6.74183 1.034
## time_firstPFT:site108 4.78104 3.43925 1.390
## time_firstPFT:site11R 2.71950 2.90867 0.935
## time_firstPFT:site12R -0.29186 4.18713 -0.070
## time_firstPFT:site13R -1.69576 4.11051 -0.413
## time_firstPFT:site14R 3.80449 18.92549 0.201
## time_firstPFT:site15R -4.23825 11.43377 -0.371
## time_firstPFT:site16R 1.81489 2.72336 0.666
## time_firstPFT:site18R 6.13767 10.81087 0.568
## time_firstPFT:site19R 3.07405 4.39427 0.700
## time_firstPFT:site20R 1.04632 3.24047 0.323
## time_firstPFT:site21R 3.71317 4.60414 0.806
## time_firstPFT:site22R -2.69525 2.73169 -0.987
## time_firstPFT:site23R 8.22993 24.67811 0.333
## time_firstPFT:site24R 0.23176 2.34722 0.099
## time_firstPFT:site25R -5.71871 2.78985 -2.050
## time_firstPFT:site28R -10.22810 11.05737 -0.925
## time_firstPFT:site29R -0.67084 4.84148 -0.139
## time_firstPFT:site31R -0.34251 2.14342 -0.160
## time_firstPFT:site32R -4.29093 3.39159 -1.265
## time_firstPFT:site33R 2.46938 4.00252 0.617
## time_firstPFT:site34R -0.93932 2.41615 -0.389
## time_firstPFT:site35R 11.44232 4.27709 2.675
## time_firstPFT:site36R 3.76742 2.88698 1.305
## time_firstPFT:site37R -1.53546 2.85700 -0.537
## time_firstPFT:site38R -4.01451 2.00934 -1.998
## time_firstPFT:site39R -48.36829 8.72026 -5.547
## time_firstPFT:site40R 0.42388 4.57939 0.093
## time_firstPFT:site41R 2.11369 5.56681 0.380
## time_firstPFT:site42R 2.29787 5.39345 0.426##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.920
## Unadjusted ICC: 0.702report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NO3_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.24. The model's intercept,
## corresponding to time_firstPFT = 0, is at 35.59 (95% CI [22.67, 48.51], t(2038)
## = 5.40, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NO3_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to
## NO3_5yrPreCensor = 0, is at 35.59 (95% CI [22.67, 48.51], t(2038) = 5.40, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to disadv = 0, is at 35.59 (95% CI [22.67,
## 48.51], t(2038) = 5.40, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to dich_Race =
## White, is at 35.59 (95% CI [22.67, 48.51], t(2038) = 5.40, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to sex = M, is at 35.59 (95% CI [22.67,
## 48.51], t(2038) = 5.40, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to age_dx = 0, is at 35.59 (95% CI [22.67,
## 48.51], t(2038) = 5.40, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to smokeHx =
## Never, is at 35.59 (95% CI [22.67, 48.51], t(2038) = 5.40, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to site = Simmons, is at 35.59 (95% CI [22.67,
## 48.51], t(2038) = 5.40, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to cohort =
## CARE-PF, is at 35.59 (95% CI [22.67, 48.51], t(2038) = 5.40, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.85, 95% CI [-4.16, 5.86], t(2038) = 0.33, p = 0.740; Std. beta =
## -0.49, 95% CI [-0.65, -0.32])
## - The effect of NO3 5yrPreCensor is statistically non-significant and negative
## (beta = -3.28, 95% CI [-8.25, 1.69], t(2038) = -1.29, p = 0.196; Std. beta =
## -0.14, 95% CI [-0.27, -0.01])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.78, 95% CI [-1.88, 9.44], t(2038) = 1.31, p = 0.190; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.97, 95% CI [-12.48, -1.45], t(2038) = -2.48, p = 0.013; Std. beta =
## -0.37, 95% CI [-0.72, -0.02])
## - The effect of sex [F] is statistically significant and positive (beta = 4.06,
## 95% CI [0.62, 7.50], t(2038) = 2.31, p = 0.021; Std. beta = 0.25, 95% CI [0.03,
## 0.47])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.79, 95% CI [0.39, 7.18], t(2038) = 2.19, p = 0.029; Std. beta = 0.27,
## 95% CI [0.06, 0.49])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.34, 95% CI [1.84, 34.84], t(2038) = 2.18, p = 0.029; Std. beta =
## 1.18, 95% CI [-0.02, 2.39])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.32, 95% CI [-10.04, 5.39], t(2038) = -0.59, p = 0.555; Std. beta =
## 0.03, 95% CI [-0.47, 0.54])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-42.29, 21.23], t(2038) = -0.65, p = 0.516; Std. beta =
## -1.85, 95% CI [-4.61, 0.92])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.47, 95% CI [-11.49, 34.43], t(2038) = 0.98, p = 0.327; Std. beta = 0.93,
## 95% CI [-0.46, 2.32])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 4.85, 95% CI [-17.45, 27.15], t(2038) = 0.43, p = 0.670; Std. beta = -0.03,
## 95% CI [-1.52, 1.46])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.19, 95% CI [-31.54, 5.16], t(2038) = -1.41, p = 0.159; Std. beta = -0.86,
## 95% CI [-2.22, 0.50])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.85, 95% CI [-21.83, 41.54], t(2038) = 0.61, p = 0.542; Std. beta = 0.58,
## 95% CI [-1.29, 2.45])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.16, 95% CI [3.12, 21.19], t(2038) = 2.64, p = 0.008; Std. beta = 0.45, 95%
## CI [-0.10, 1.00])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 19.29, 95% CI [-3.09, 41.66], t(2038) = 1.69, p = 0.091; Std. beta = 0.57,
## 95% CI [-0.86, 2.00])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-2.80, 9.70], t(2038) = 1.08, p = 0.279; Std. beta = 0.13, 95%
## CI [-0.26, 0.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.68, 95% CI [-1.60, 22.95], t(2038) = 1.71, p = 0.088; Std. beta = 0.35,
## 95% CI [-0.40, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.92, 95% CI [-10.47, 2.63], t(2038) = -1.17, p = 0.240; Std. beta = -0.16,
## 95% CI [-0.58, 0.25])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.17, 95% CI [-23.15, 2.81], t(2038) = -1.54, p = 0.124; Std. beta = -0.11,
## 95% CI [-1.03, 0.81])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-3.55, 9.31], t(2038) = 0.88, p = 0.380; Std. beta = 0.07, 95%
## CI [-0.33, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-13.75, 2.37], t(2038) = -1.38, p = 0.166; Std. beta = -0.11,
## 95% CI [-0.61, 0.39])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-26.27, 18.88], t(2038) = -0.32, p = 0.748; Std. beta = 0.41,
## 95% CI [-1.15, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-17.30, 21.32], t(2038) = 0.20, p = 0.838; Std. beta = 0.55,
## 95% CI [-0.64, 1.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-26.68, 40.06], t(2038) = 0.39, p = 0.694; Std. beta = 0.39,
## 95% CI [-1.57, 2.36])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.17, 95% CI [-6.26, 22.59], t(2038) = 1.11, p = 0.267; Std. beta = 0.73, 95%
## CI [-0.20, 1.65])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.02, 95% CI [-16.21, 28.25], t(2038) = 0.53, p = 0.595; Std. beta = 0.33,
## 95% CI [-1.10, 1.75])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.30, 95% CI [-0.59, 33.19], t(2038) = 1.89, p = 0.059; Std. beta = 0.81,
## 95% CI [-0.24, 1.86])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.08, 95% CI [-23.62, 33.77], t(2038) = 0.35, p = 0.729; Std. beta = 0.64,
## 95% CI [-1.96, 3.24])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.92, 95% CI [-68.97, -4.86], t(2038) = -2.26, p = 0.024; Std. beta = -2.56,
## 95% CI [-4.91, -0.20])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.28, 95% CI [-23.58, 5.02], t(2038) = -1.27, p = 0.203; Std. beta = -0.38,
## 95% CI [-1.30, 0.53])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-22.65, 41.36], t(2038) = 0.57, p = 0.567; Std. beta = 0.55,
## 95% CI [-1.34, 2.44])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-28.10, 17.38], t(2038) = -0.46, p = 0.644; Std. beta = 0.23,
## 95% CI [-1.87, 2.34])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-10.40, 19.90], t(2038) = 0.61, p = 0.539; Std. beta = 0.56,
## 95% CI [-0.51, 1.62])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.37, 95% CI [-11.78, 14.52], t(2038) = 0.20, p = 0.838; Std. beta = 0.17,
## 95% CI [-0.70, 1.05])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.02, 95% CI [-29.82, 31.86], t(2038) = 0.06, p = 0.948; Std. beta = 0.39,
## 95% CI [-1.46, 2.25])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-12.25, 8.01], t(2038) = -0.41, p = 0.682; Std. beta = -0.37,
## 95% CI [-1.05, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -15.10, 95% CI [-32.58, 2.37], t(2038) = -1.70, p = 0.090; Std. beta = -0.15,
## 95% CI [-4.21, 3.90])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.10, 95% CI [-6.93, 17.14], t(2038) = 0.83, p = 0.406; Std. beta = 0.32, 95%
## CI [-0.43, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.34, 95% CI [-11.93, 14.60], t(2038) = 0.20, p = 0.843; Std. beta = -0.43,
## 95% CI [-1.27, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.32, 95% CI [-14.20, 22.85], t(2038) = 0.46, p = 0.647; Std. beta = -0.66,
## 95% CI [-2.74, 1.42])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.85, 95% CI [-39.38, 23.69], t(2038) = -0.49, p = 0.626; Std. beta = -0.52,
## 95% CI [-2.39, 1.35])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 3.20, 95% CI [-11.29, 17.69], t(2038) = 0.43, p = 0.665; Std. beta = 0.16,
## 95% CI [-0.72, 1.03])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.05, 95% CI [-9.18, 23.28], t(2038) = 0.85, p = 0.395; Std. beta = 0.03, 95%
## CI [-1.00, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.90, 95% CI [-31.92, 0.12], t(2038) = -1.95, p = 0.052; Std. beta = -0.72,
## 95% CI [-1.81, 0.38])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -1.07, 95% CI [-13.17, 11.03], t(2038) = -0.17, p = 0.862; Std. beta = -0.15,
## 95% CI [-0.91, 0.61])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -2.85, 95% CI [-21.60, 15.90], t(2038) = -0.30, p = 0.765; Std. beta = 0.86,
## 95% CI [-0.35, 2.06])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-25.76, 2.66], t(2038) = -1.59, p = 0.111; Std. beta = -0.34,
## 95% CI [-1.26, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.40, 95% CI [-0.44, 31.24], t(2038) = 1.91, p = 0.057; Std. beta = 0.77,
## 95% CI [-0.21, 1.75])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 9.97, 95% CI [-1.19, 21.13], t(2038) = 1.75, p = 0.080; Std. beta = 0.23, 95%
## CI [-0.46, 0.92])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 20.88, 95% CI [-11.26, 53.03], t(2038) = 1.27, p = 0.203; Std. beta = -3.10,
## 95% CI [-5.25, -0.94])
## - The effect of site [40R] is statistically significant and positive (beta =
## 27.91, 95% CI [5.47, 50.35], t(2038) = 2.44, p = 0.015; Std. beta = 1.68, 95%
## CI [0.22, 3.15])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.27, 95% CI [-21.63, 15.09], t(2038) = -0.35, p = 0.727; Std. beta =
## -3.58e-03, 95% CI [-1.30, 1.29])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-11.05, 8.85], t(2038) = -0.22, p = 0.829; Std. beta = 0.14,
## 95% CI [-0.82, 1.10])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and negative (beta = -2.00, 95% CI [-4.34, 0.35], t(2038) =
## -1.67, p = 0.095; Std. beta = -0.08, 95% CI [-0.18, 0.01])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 6.85e-03, 95% CI [-2.17, 2.18], t(2038) = 6.18e-03, p = 0.995;
## Std. beta = 2.10e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.46, 95% CI [-1.77, 2.68], t(2038) =
## 0.40, p = 0.687; Std. beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-1.17, 1.45], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.01, 95% CI [-0.13, 0.16])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.02e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.96e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.77, 1.88], t(2038) =
## 0.82, p = 0.414; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.14, 95% CI [-9.25, 11.53], t(2038) =
## 0.22, p = 0.829; Std. beta = 0.12, 95% CI [-1.00, 1.24])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.88, 95% CI [-1.44, 5.20], t(2038) =
## 1.11, p = 0.267; Std. beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -13.68, 95% CI [-42.63, 15.26], t(2038) = -0.93, p = 0.354;
## Std. beta = -1.47, 95% CI [-4.59, 1.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-7.15, 12.83], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.31, 95% CI [-0.77, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.53, 95% CI [-14.57, 7.51], t(2038) = -0.63, p = 0.531; Std.
## beta = -0.38, 95% CI [-1.57, 0.81])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.15, 11.36], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.84, -0.08], t(2038) = -2.02, p = 0.044; Std.
## beta = -0.32, 95% CI [-0.63, -8.97e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.83, 2.15], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-3.00, 1.33], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.09, 95% CI [-0.32, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-7.39, 1.11], t(2038) = -1.45, p = 0.148; Std.
## beta = -0.34, 95% CI [-0.80, 0.12])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-1.81, 3.32], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.08, 95% CI [-0.20, 0.36])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-1.67, 12.57], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.59, 95% CI [-0.18, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-3.39, 1.24], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.12, 95% CI [-0.37, 0.13])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-0.67, 5.77], t(2038) = 1.55, p = 0.121; Std.
## beta = 0.27, 95% CI [-0.07, 0.62])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.97, 95% CI [-6.25, 20.19], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.75, 95% CI [-0.67, 2.17])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.78, 95% CI [-1.96, 11.53], t(2038) = 1.39, p = 0.165; Std.
## beta = 0.51, 95% CI [-0.21, 1.24])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-2.98, 8.42], t(2038) = 0.93, p = 0.350; Std.
## beta = 0.29, 95% CI [-0.32, 0.91])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-8.50, 7.92], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.92, 0.85])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.76, 6.37], t(2038) = -0.41, p = 0.680; Std.
## beta = -0.18, 95% CI [-1.05, 0.69])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.80, 95% CI [-33.31, 40.92], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.41, 95% CI [-3.59, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -4.24, 95% CI [-26.66, 18.18], t(2038) = -0.37, p = 0.711;
## Std. beta = -0.46, 95% CI [-2.87, 1.96])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-3.53, 7.16], t(2038) = 0.67, p = 0.505; Std.
## beta = 0.20, 95% CI [-0.38, 0.77])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.06, 27.34], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.07, 95% CI [-5.54, 11.69], t(2038) = 0.70, p = 0.484; Std.
## beta = 0.33, 95% CI [-0.60, 1.26])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-5.31, 7.40], t(2038) = 0.32, p = 0.747; Std.
## beta = 0.11, 95% CI [-0.57, 0.80])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.71, 95% CI [-5.32, 12.74], t(2038) = 0.81, p = 0.420; Std.
## beta = 0.40, 95% CI [-0.57, 1.37])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-8.05, 2.66], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.29, 95% CI [-0.87, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.23, 95% CI [-40.17, 56.63], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.89, 95% CI [-4.33, 6.10])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.23, 95% CI [-4.37, 4.83], t(2038) = 0.10, p = 0.921; Std.
## beta = 0.02, 95% CI [-0.47, 0.52])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.72, 95% CI [-11.19, -0.25], t(2038) = -2.05, p = 0.041;
## Std. beta = -0.62, 95% CI [-1.21, -0.03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.23, 95% CI [-31.91, 11.46], t(2038) = -0.93, p = 0.355;
## Std. beta = -1.10, 95% CI [-3.44, 1.23])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-10.17, 8.82], t(2038) = -0.14, p = 0.890; Std.
## beta = -0.07, 95% CI [-1.09, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-4.55, 3.86], t(2038) = -0.16, p = 0.873; Std.
## beta = -0.04, 95% CI [-0.49, 0.42])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-10.94, 2.36], t(2038) = -1.27, p = 0.206; Std.
## beta = -0.46, 95% CI [-1.18, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-5.38, 10.32], t(2038) = 0.62, p = 0.537; Std.
## beta = 0.27, 95% CI [-0.58, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-5.68, 3.80], t(2038) = -0.39, p = 0.697; Std.
## beta = -0.10, 95% CI [-0.61, 0.41])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.44, 95% CI [3.05, 19.83], t(2038) = 2.68, p = 0.008; Std.
## beta = 1.23, 95% CI [0.33, 2.14])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-1.89, 9.43], t(2038) = 1.30, p = 0.192; Std.
## beta = 0.41, 95% CI [-0.20, 1.02])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-7.14, 4.07], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.77, 0.44])
## - The effect of time firstPFT × site [38R] is statistically significant and
## negative (beta = -4.01, 95% CI [-7.96, -0.07], t(2038) = -2.00, p = 0.046; Std.
## beta = -0.43, 95% CI [-0.86, -7.97e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -48.37, 95% CI [-65.47, -31.27], t(2038) = -5.55, p < .001;
## Std. beta = -5.21, 95% CI [-7.05, -3.37])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.42, 95% CI [-8.56, 9.40], t(2038) = 0.09, p = 0.926; Std.
## beta = 0.05, 95% CI [-0.92, 1.01])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-8.80, 13.03], t(2038) = 0.38, p = 0.704; Std.
## beta = 0.23, 95% CI [-0.95, 1.40])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.30, 95% CI [-8.28, 12.88], t(2038) = 0.43, p = 0.670; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*NH4_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14551
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3219 -0.4376 -0.0212 0.4480 4.4896
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 250.62 15.831
## time_firstPFT 12.96 3.601 -0.13
## Residual 25.58 5.057
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 70.3667 3.5106 20.044
## time_firstPFT -3.0354 1.2205 -2.487
## NH4_5yrPreCensor -7.8678 2.3748 -3.313
## site02R -16.5268 16.8443 -0.981
## site03R 4.8910 12.2291 0.400
## site04R -2.7725 11.7635 -0.236
## site05R -17.5180 9.7932 -1.789
## site06R 13.6623 11.9789 1.141
## site07R 6.0290 5.0964 1.183
## site09R 13.7425 11.9392 1.151
## site101 -4.2134 3.8886 -1.084
## site102 1.8355 6.8535 0.268
## site103 -10.8014 4.0135 -2.691
## site104 -15.4885 7.0561 -2.195
## site105 -3.6559 3.9895 -0.916
## site106 -10.1463 4.5600 -2.225
## site107 -13.0884 12.0382 -1.087
## site108 -9.7487 9.9436 -0.980
## site10R 2.6218 17.4034 0.151
## site11R 5.3360 7.8082 0.683
## site12R 2.7986 11.9624 0.234
## site13R 8.6582 9.0443 0.957
## site14R -0.7413 15.0509 -0.049
## site15R -36.6777 16.8891 -2.172
## site16R -22.4475 7.7395 -2.900
## site17R -1.2335 16.8052 -0.073
## site18R -8.1550 12.0956 -0.674
## site19R -1.7201 8.1174 -0.212
## site20R -4.0169 7.2486 -0.554
## site21R -4.6752 16.4277 -0.285
## site22R -4.9356 5.5343 -0.892
## site23R -18.3461 7.8817 -2.328
## site24R -1.5661 6.7173 -0.233
## site25R -6.1548 7.2629 -0.847
## site28R -5.1466 9.8354 -0.523
## site29R -12.9347 16.7310 -0.773
## site31R -4.4716 7.7991 -0.573
## site32R 2.6629 8.7784 0.303
## site33R -23.1312 8.5774 -2.697
## site34R -4.8758 6.6820 -0.730
## site35R -3.3873 10.0478 -0.337
## site36R -18.9182 7.6879 -2.461
## site37R 5.7631 8.5018 0.678
## site38R 3.7442 6.1722 0.607
## site39R 9.4793 16.7137 0.567
## site40R 22.8678 11.7661 1.944
## site41R -8.6542 9.8656 -0.877
## site42R -6.7820 5.5007 -1.233
## time_firstPFT:NH4_5yrPreCensor -0.8334 0.8571 -0.972
## time_firstPFT:site02R -16.0073 14.7423 -1.086
## time_firstPFT:site03R 0.6662 5.0898 0.131
## time_firstPFT:site04R -5.7466 5.5348 -1.038
## time_firstPFT:site05R -1.5522 6.2371 -0.249
## time_firstPFT:site06R -3.7246 4.8166 -0.773
## time_firstPFT:site07R -4.6088 1.5447 -2.984
## time_firstPFT:site09R -7.2260 4.2894 -1.685
## time_firstPFT:site101 -1.4598 1.2890 -1.132
## time_firstPFT:site102 -3.4697 2.2658 -1.531
## time_firstPFT:site103 0.9379 1.3834 0.678
## time_firstPFT:site104 5.2957 3.5896 1.475
## time_firstPFT:site105 -1.1751 1.3430 -0.875
## time_firstPFT:site106 1.3518 1.7042 0.793
## time_firstPFT:site107 6.7370 6.7361 1.000
## time_firstPFT:site108 5.5179 3.2048 1.722
## time_firstPFT:site11R 2.1519 2.8636 0.751
## time_firstPFT:site12R -1.2685 4.1692 -0.304
## time_firstPFT:site13R -2.7359 4.0840 -0.670
## time_firstPFT:site14R 2.7827 18.9146 0.147
## time_firstPFT:site15R -3.8733 11.3896 -0.340
## time_firstPFT:site16R 1.4788 2.7447 0.539
## time_firstPFT:site18R 5.7691 10.7851 0.535
## time_firstPFT:site19R 2.3446 4.3007 0.545
## time_firstPFT:site20R -0.1395 3.2480 -0.043
## time_firstPFT:site21R 3.4991 4.5678 0.766
## time_firstPFT:site22R -4.3259 2.7482 -1.574
## time_firstPFT:site23R 0.6165 5.0441 0.122
## time_firstPFT:site24R -0.8654 2.4333 -0.356
## time_firstPFT:site25R -7.2840 2.8195 -2.583
## time_firstPFT:site28R -12.3408 10.9580 -1.126
## time_firstPFT:site29R -1.5536 4.7850 -0.325
## time_firstPFT:site31R -0.1811 2.1230 -0.085
## time_firstPFT:site32R -4.9720 3.3889 -1.467
## time_firstPFT:site33R 2.1631 3.8960 0.555
## time_firstPFT:site34R -1.3405 2.4517 -0.547
## time_firstPFT:site35R 10.7888 4.2264 2.553
## time_firstPFT:site36R 2.5641 2.8917 0.887
## time_firstPFT:site37R -3.1233 2.8089 -1.112
## time_firstPFT:site38R -3.9437 2.0349 -1.938
## time_firstPFT:site39R -47.0773 8.5826 -5.485
## time_firstPFT:site40R -0.9456 4.4890 -0.211
## time_firstPFT:site41R 0.3262 5.5684 0.059
## time_firstPFT:site42R 0.5715 5.4032 0.106##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.922
## Unadjusted ICC: 0.739report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NH4_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.20. The model's
## intercept, corresponding to time_firstPFT = 0, is at 70.37 (95% CI [63.48,
## 77.25], t(2068) = 20.04, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.04, 95% CI [-5.43, -0.64], t(2068) = -2.49, p = 0.013; Std. beta = -0.39,
## 95% CI [-0.54, -0.25])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.87, 95% CI [-12.53, -3.21], t(2068) = -3.31, p < .001; Std. beta =
## -0.32, 95% CI [-0.50, -0.15])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -16.53, 95% CI [-49.56, 16.51], t(2068) = -0.98, p = 0.327; Std. beta =
## -2.40, 95% CI [-5.20, 0.39])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.89, 95% CI [-19.09, 28.87], t(2068) = 0.40, p = 0.689; Std. beta = 0.35,
## 95% CI [-1.08, 1.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.77, 95% CI [-25.84, 20.30], t(2068) = -0.24, p = 0.814; Std. beta = -0.68,
## 95% CI [-2.19, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -17.52, 95% CI [-36.72, 1.69], t(2068) = -1.79, p = 0.074; Std. beta = -1.17,
## 95% CI [-2.55, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 13.66, 95% CI [-9.83, 37.15], t(2068) = 1.14, p = 0.254; Std. beta = 0.47,
## 95% CI [-1.02, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-3.97, 16.02], t(2068) = 1.18, p = 0.237; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 13.74, 95% CI [-9.67, 37.16], t(2068) = 1.15, p = 0.250; Std. beta = 0.17,
## 95% CI [-1.30, 1.63])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -4.21, 95% CI [-11.84, 3.41], t(2068) = -1.08, p = 0.279; Std. beta = -0.38,
## 95% CI [-0.85, 0.09])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.84, 95% CI [-11.60, 15.28], t(2068) = 0.27, p = 0.789; Std. beta = -0.20,
## 95% CI [-1.01, 0.61])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.80, 95% CI [-18.67, -2.93], t(2068) = -2.69, p = 0.007; Std. beta = -0.55,
## 95% CI [-1.04, -0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.49, 95% CI [-29.33, -1.65], t(2068) = -2.20, p = 0.028; Std. beta = -0.44,
## 95% CI [-1.39, 0.50])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-11.48, 4.17], t(2068) = -0.92, p = 0.360; Std. beta = -0.32,
## 95% CI [-0.80, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.15, 95% CI [-19.09, -1.20], t(2068) = -2.23, p = 0.026; Std. beta = -0.48,
## 95% CI [-1.02, 0.07])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-36.70, 10.52], t(2068) = -1.09, p = 0.277; Std. beta =
## -0.17, 95% CI [-1.76, 1.42])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-29.25, 9.75], t(2068) = -0.98, p = 0.327; Std. beta = -0.08,
## 95% CI [-1.25, 1.08])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.62, 95% CI [-31.51, 36.75], t(2068) = 0.15, p = 0.880; Std. beta = 0.15,
## 95% CI [-1.86, 2.17])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.34, 95% CI [-9.98, 20.65], t(2068) = 0.68, p = 0.494; Std. beta = 0.51, 95%
## CI [-0.45, 1.46])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 2.80, 95% CI [-20.66, 26.26], t(2068) = 0.23, p = 0.815; Std. beta = 0.05,
## 95% CI [-1.42, 1.52])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 8.66, 95% CI [-9.08, 26.40], t(2068) = 0.96, p = 0.339; Std. beta = 0.27, 95%
## CI [-0.82, 1.35])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-30.26, 28.78], t(2068) = -0.05, p = 0.961; Std. beta = 0.20,
## 95% CI [-2.41, 2.82])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.68, 95% CI [-69.80, -3.56], t(2068) = -2.17, p = 0.030; Std. beta = -2.51,
## 95% CI [-4.89, -0.13])
## - The effect of site [16R] is statistically significant and negative (beta =
## -22.45, 95% CI [-37.63, -7.27], t(2068) = -2.90, p = 0.004; Std. beta = -1.19,
## 95% CI [-2.14, -0.24])
## - The effect of site [17R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-34.19, 31.72], t(2068) = -0.07, p = 0.941; Std. beta = -0.07,
## 95% CI [-2.02, 1.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2068) = -0.67, p = 0.500; Std. beta = 0.03,
## 95% CI [-2.09, 2.16])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.72, 95% CI [-17.64, 14.20], t(2068) = -0.21, p = 0.832; Std. beta = 0.11,
## 95% CI [-0.97, 1.19])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.02, 95% CI [-18.23, 10.20], t(2068) = -0.55, p = 0.580; Std. beta = -0.25,
## 95% CI [-1.16, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -4.68, 95% CI [-36.89, 27.54], t(2068) = -0.28, p = 0.776; Std. beta = 0.04,
## 95% CI [-1.87, 1.94])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-15.79, 5.92], t(2068) = -0.89, p = 0.373; Std. beta = -0.68,
## 95% CI [-1.39, 0.04])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.80, -2.89], t(2068) = -2.33, p = 0.020; Std. beta = -1.03,
## 95% CI [-2.19, 0.13])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-14.74, 11.61], t(2068) = -0.23, p = 0.816; Std. beta = -0.17,
## 95% CI [-0.98, 0.64])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-20.40, 8.09], t(2068) = -0.85, p = 0.397; Std. beta = -1.01,
## 95% CI [-1.89, -0.13])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -5.15, 95% CI [-24.43, 14.14], t(2068) = -0.52, p = 0.601; Std. beta = -1.40,
## 95% CI [-3.47, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-45.75, 19.88], t(2068) = -0.77, p = 0.440; Std. beta =
## -0.90, 95% CI [-2.82, 1.02])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.47, 95% CI [-19.77, 10.82], t(2068) = -0.57, p = 0.566; Std. beta = -0.28,
## 95% CI [-1.19, 0.63])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.66, 95% CI [-14.55, 19.88], t(2068) = 0.30, p = 0.762; Std. beta = -0.29,
## 95% CI [-1.36, 0.79])
## - The effect of site [33R] is statistically significant and negative (beta =
## -23.13, 95% CI [-39.95, -6.31], t(2068) = -2.70, p = 0.007; Std. beta = -1.17,
## 95% CI [-2.29, -0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-17.98, 8.23], t(2068) = -0.73, p = 0.466; Std. beta = -0.41,
## 95% CI [-1.21, 0.40])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-23.09, 16.32], t(2068) = -0.34, p = 0.736; Std. beta = 0.76,
## 95% CI [-0.47, 2.00])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.00, -3.84], t(2068) = -2.46, p = 0.014; Std. beta = -0.89,
## 95% CI [-1.84, 0.06])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-10.91, 22.44], t(2068) = 0.68, p = 0.498; Std. beta = 0.06,
## 95% CI [-0.95, 1.07])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.36, 15.85], t(2068) = 0.61, p = 0.544; Std. beta = -0.13,
## 95% CI [-0.87, 0.60])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.48, 95% CI [-23.30, 42.26], t(2068) = 0.57, p = 0.571; Std. beta = -3.64,
## 95% CI [-5.79, -1.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 22.87, 95% CI [-0.21, 45.94], t(2068) = 1.94, p = 0.052; Std. beta = 1.26,
## 95% CI [-0.21, 2.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-28.00, 10.69], t(2068) = -0.88, p = 0.380; Std. beta = -0.48,
## 95% CI [-1.81, 0.85])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.78, 95% CI [-17.57, 4.01], t(2068) = -1.23, p = 0.218; Std. beta = -0.35,
## 95% CI [-1.33, 0.63])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.83, 95% CI [-2.51, 0.85], t(2068) =
## -0.97, p = 0.331; Std. beta = -0.05, 95% CI [-0.16, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -16.01, 95% CI [-44.92, 12.90], t(2068) = -1.09, p = 0.278;
## Std. beta = -1.72, 95% CI [-4.83, 1.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-9.32, 10.65], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-1.00, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.75, 95% CI [-16.60, 5.11], t(2068) = -1.04, p = 0.299; Std.
## beta = -0.62, 95% CI [-1.78, 0.55])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-13.78, 10.68], t(2068) = -0.25, p = 0.803;
## Std. beta = -0.17, 95% CI [-1.48, 1.15])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.72, 95% CI [-13.17, 5.72], t(2068) = -0.77, p = 0.439; Std.
## beta = -0.40, 95% CI [-1.41, 0.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.61, 95% CI [-7.64, -1.58], t(2068) = -2.98, p = 0.003; Std.
## beta = -0.50, 95% CI [-0.82, -0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.23, 95% CI [-15.64, 1.19], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.78, 95% CI [-1.68, 0.13])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.46, 95% CI [-3.99, 1.07], t(2068) = -1.13, p = 0.258; Std.
## beta = -0.16, 95% CI [-0.43, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.47, 95% CI [-7.91, 0.97], t(2068) = -1.53, p = 0.126; Std.
## beta = -0.37, 95% CI [-0.85, 0.10])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-1.78, 3.65], t(2068) = 0.68, p = 0.498; Std.
## beta = 0.10, 95% CI [-0.19, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-1.74, 12.34], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.57, 95% CI [-0.19, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-3.81, 1.46], t(2068) = -0.87, p = 0.382; Std.
## beta = -0.13, 95% CI [-0.41, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-1.99, 4.69], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.15, 95% CI [-0.21, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.74, 95% CI [-6.47, 19.95], t(2068) = 1.00, p = 0.317; Std.
## beta = 0.72, 95% CI [-0.70, 2.14])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.52, 95% CI [-0.77, 11.80], t(2068) = 1.72, p = 0.085; Std.
## beta = 0.59, 95% CI [-0.08, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-3.46, 7.77], t(2068) = 0.75, p = 0.452; Std.
## beta = 0.23, 95% CI [-0.37, 0.83])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-9.44, 6.91], t(2068) = -0.30, p = 0.761; Std.
## beta = -0.14, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-10.75, 5.27], t(2068) = -0.67, p = 0.503; Std.
## beta = -0.29, 95% CI [-1.15, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-34.31, 39.88], t(2068) = 0.15, p = 0.883; Std.
## beta = 0.30, 95% CI [-3.69, 4.28])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-26.21, 18.46], t(2068) = -0.34, p = 0.734;
## Std. beta = -0.42, 95% CI [-2.82, 1.98])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-3.90, 6.86], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.16, 95% CI [-0.42, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.77, 95% CI [-15.38, 26.92], t(2068) = 0.53, p = 0.593; Std.
## beta = 0.62, 95% CI [-1.65, 2.89])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.34, 95% CI [-6.09, 10.78], t(2068) = 0.55, p = 0.586; Std.
## beta = 0.25, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-6.51, 6.23], t(2068) = -0.04, p = 0.966; Std.
## beta = -0.01, 95% CI [-0.70, 0.67])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-5.46, 12.46], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.38, 95% CI [-0.59, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.33, 95% CI [-9.72, 1.06], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.46, 95% CI [-1.04, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-9.28, 10.51], t(2068) = 0.12, p = 0.903; Std.
## beta = 0.07, 95% CI [-1.00, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-5.64, 3.91], t(2068) = -0.36, p = 0.722; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -7.28, 95% CI [-12.81, -1.75], t(2068) = -2.58, p = 0.010;
## Std. beta = -0.78, 95% CI [-1.38, -0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -12.34, 95% CI [-33.83, 9.15], t(2068) = -1.13, p = 0.260;
## Std. beta = -1.33, 95% CI [-3.63, 0.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-10.94, 7.83], t(2068) = -0.32, p = 0.745; Std.
## beta = -0.17, 95% CI [-1.18, 0.84])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.18, 95% CI [-4.34, 3.98], t(2068) = -0.09, p = 0.932; Std.
## beta = -0.02, 95% CI [-0.47, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.97, 95% CI [-11.62, 1.67], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.53, 95% CI [-1.25, 0.18])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-5.48, 9.80], t(2068) = 0.56, p = 0.579; Std.
## beta = 0.23, 95% CI [-0.59, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.15, 3.47], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.14, 95% CI [-0.66, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.79, 95% CI [2.50, 19.08], t(2068) = 2.55, p = 0.011; Std.
## beta = 1.16, 95% CI [0.27, 2.05])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-3.11, 8.23], t(2068) = 0.89, p = 0.375; Std.
## beta = 0.28, 95% CI [-0.33, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -3.12, 95% CI [-8.63, 2.39], t(2068) = -1.11, p = 0.266; Std.
## beta = -0.34, 95% CI [-0.93, 0.26])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.94, 95% CI [-7.93, 0.05], t(2068) = -1.94, p = 0.053; Std.
## beta = -0.42, 95% CI [-0.85, 5.04e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-63.91, -30.25], t(2068) = -5.49, p < .001;
## Std. beta = -5.06, 95% CI [-6.87, -3.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-9.75, 7.86], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.10, 95% CI [-1.05, 0.84])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-10.59, 11.25], t(2068) = 0.06, p = 0.953; Std.
## beta = 0.04, 95% CI [-1.14, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-10.02, 11.17], t(2068) = 0.11, p = 0.916; Std.
## beta = 0.06, 95% CI [-1.08, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NH4_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to NH4_5yrPreCensor = 0, is at 70.37 (95% CI [63.48, 77.25],
## t(2068) = 20.04, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.04, 95% CI [-5.43, -0.64], t(2068) = -2.49, p = 0.013; Std. beta = -0.39,
## 95% CI [-0.54, -0.25])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.87, 95% CI [-12.53, -3.21], t(2068) = -3.31, p < .001; Std. beta =
## -0.32, 95% CI [-0.50, -0.15])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -16.53, 95% CI [-49.56, 16.51], t(2068) = -0.98, p = 0.327; Std. beta =
## -2.40, 95% CI [-5.20, 0.39])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.89, 95% CI [-19.09, 28.87], t(2068) = 0.40, p = 0.689; Std. beta = 0.35,
## 95% CI [-1.08, 1.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.77, 95% CI [-25.84, 20.30], t(2068) = -0.24, p = 0.814; Std. beta = -0.68,
## 95% CI [-2.19, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -17.52, 95% CI [-36.72, 1.69], t(2068) = -1.79, p = 0.074; Std. beta = -1.17,
## 95% CI [-2.55, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 13.66, 95% CI [-9.83, 37.15], t(2068) = 1.14, p = 0.254; Std. beta = 0.47,
## 95% CI [-1.02, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-3.97, 16.02], t(2068) = 1.18, p = 0.237; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 13.74, 95% CI [-9.67, 37.16], t(2068) = 1.15, p = 0.250; Std. beta = 0.17,
## 95% CI [-1.30, 1.63])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -4.21, 95% CI [-11.84, 3.41], t(2068) = -1.08, p = 0.279; Std. beta = -0.38,
## 95% CI [-0.85, 0.09])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.84, 95% CI [-11.60, 15.28], t(2068) = 0.27, p = 0.789; Std. beta = -0.20,
## 95% CI [-1.01, 0.61])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.80, 95% CI [-18.67, -2.93], t(2068) = -2.69, p = 0.007; Std. beta = -0.55,
## 95% CI [-1.04, -0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.49, 95% CI [-29.33, -1.65], t(2068) = -2.20, p = 0.028; Std. beta = -0.44,
## 95% CI [-1.39, 0.50])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-11.48, 4.17], t(2068) = -0.92, p = 0.360; Std. beta = -0.32,
## 95% CI [-0.80, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.15, 95% CI [-19.09, -1.20], t(2068) = -2.23, p = 0.026; Std. beta = -0.48,
## 95% CI [-1.02, 0.07])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-36.70, 10.52], t(2068) = -1.09, p = 0.277; Std. beta =
## -0.17, 95% CI [-1.76, 1.42])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-29.25, 9.75], t(2068) = -0.98, p = 0.327; Std. beta = -0.08,
## 95% CI [-1.25, 1.08])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.62, 95% CI [-31.51, 36.75], t(2068) = 0.15, p = 0.880; Std. beta = 0.15,
## 95% CI [-1.86, 2.17])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.34, 95% CI [-9.98, 20.65], t(2068) = 0.68, p = 0.494; Std. beta = 0.51, 95%
## CI [-0.45, 1.46])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 2.80, 95% CI [-20.66, 26.26], t(2068) = 0.23, p = 0.815; Std. beta = 0.05,
## 95% CI [-1.42, 1.52])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 8.66, 95% CI [-9.08, 26.40], t(2068) = 0.96, p = 0.339; Std. beta = 0.27, 95%
## CI [-0.82, 1.35])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-30.26, 28.78], t(2068) = -0.05, p = 0.961; Std. beta = 0.20,
## 95% CI [-2.41, 2.82])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.68, 95% CI [-69.80, -3.56], t(2068) = -2.17, p = 0.030; Std. beta = -2.51,
## 95% CI [-4.89, -0.13])
## - The effect of site [16R] is statistically significant and negative (beta =
## -22.45, 95% CI [-37.63, -7.27], t(2068) = -2.90, p = 0.004; Std. beta = -1.19,
## 95% CI [-2.14, -0.24])
## - The effect of site [17R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-34.19, 31.72], t(2068) = -0.07, p = 0.941; Std. beta = -0.07,
## 95% CI [-2.02, 1.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2068) = -0.67, p = 0.500; Std. beta = 0.03,
## 95% CI [-2.09, 2.16])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.72, 95% CI [-17.64, 14.20], t(2068) = -0.21, p = 0.832; Std. beta = 0.11,
## 95% CI [-0.97, 1.19])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.02, 95% CI [-18.23, 10.20], t(2068) = -0.55, p = 0.580; Std. beta = -0.25,
## 95% CI [-1.16, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -4.68, 95% CI [-36.89, 27.54], t(2068) = -0.28, p = 0.776; Std. beta = 0.04,
## 95% CI [-1.87, 1.94])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-15.79, 5.92], t(2068) = -0.89, p = 0.373; Std. beta = -0.68,
## 95% CI [-1.39, 0.04])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.80, -2.89], t(2068) = -2.33, p = 0.020; Std. beta = -1.03,
## 95% CI [-2.19, 0.13])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-14.74, 11.61], t(2068) = -0.23, p = 0.816; Std. beta = -0.17,
## 95% CI [-0.98, 0.64])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-20.40, 8.09], t(2068) = -0.85, p = 0.397; Std. beta = -1.01,
## 95% CI [-1.89, -0.13])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -5.15, 95% CI [-24.43, 14.14], t(2068) = -0.52, p = 0.601; Std. beta = -1.40,
## 95% CI [-3.47, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-45.75, 19.88], t(2068) = -0.77, p = 0.440; Std. beta =
## -0.90, 95% CI [-2.82, 1.02])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.47, 95% CI [-19.77, 10.82], t(2068) = -0.57, p = 0.566; Std. beta = -0.28,
## 95% CI [-1.19, 0.63])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.66, 95% CI [-14.55, 19.88], t(2068) = 0.30, p = 0.762; Std. beta = -0.29,
## 95% CI [-1.36, 0.79])
## - The effect of site [33R] is statistically significant and negative (beta =
## -23.13, 95% CI [-39.95, -6.31], t(2068) = -2.70, p = 0.007; Std. beta = -1.17,
## 95% CI [-2.29, -0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-17.98, 8.23], t(2068) = -0.73, p = 0.466; Std. beta = -0.41,
## 95% CI [-1.21, 0.40])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-23.09, 16.32], t(2068) = -0.34, p = 0.736; Std. beta = 0.76,
## 95% CI [-0.47, 2.00])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.00, -3.84], t(2068) = -2.46, p = 0.014; Std. beta = -0.89,
## 95% CI [-1.84, 0.06])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-10.91, 22.44], t(2068) = 0.68, p = 0.498; Std. beta = 0.06,
## 95% CI [-0.95, 1.07])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.36, 15.85], t(2068) = 0.61, p = 0.544; Std. beta = -0.13,
## 95% CI [-0.87, 0.60])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.48, 95% CI [-23.30, 42.26], t(2068) = 0.57, p = 0.571; Std. beta = -3.64,
## 95% CI [-5.79, -1.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 22.87, 95% CI [-0.21, 45.94], t(2068) = 1.94, p = 0.052; Std. beta = 1.26,
## 95% CI [-0.21, 2.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-28.00, 10.69], t(2068) = -0.88, p = 0.380; Std. beta = -0.48,
## 95% CI [-1.81, 0.85])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.78, 95% CI [-17.57, 4.01], t(2068) = -1.23, p = 0.218; Std. beta = -0.35,
## 95% CI [-1.33, 0.63])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.83, 95% CI [-2.51, 0.85], t(2068) =
## -0.97, p = 0.331; Std. beta = -0.05, 95% CI [-0.16, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -16.01, 95% CI [-44.92, 12.90], t(2068) = -1.09, p = 0.278;
## Std. beta = -1.72, 95% CI [-4.83, 1.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-9.32, 10.65], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-1.00, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.75, 95% CI [-16.60, 5.11], t(2068) = -1.04, p = 0.299; Std.
## beta = -0.62, 95% CI [-1.78, 0.55])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-13.78, 10.68], t(2068) = -0.25, p = 0.803;
## Std. beta = -0.17, 95% CI [-1.48, 1.15])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.72, 95% CI [-13.17, 5.72], t(2068) = -0.77, p = 0.439; Std.
## beta = -0.40, 95% CI [-1.41, 0.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.61, 95% CI [-7.64, -1.58], t(2068) = -2.98, p = 0.003; Std.
## beta = -0.50, 95% CI [-0.82, -0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.23, 95% CI [-15.64, 1.19], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.78, 95% CI [-1.68, 0.13])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.46, 95% CI [-3.99, 1.07], t(2068) = -1.13, p = 0.258; Std.
## beta = -0.16, 95% CI [-0.43, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.47, 95% CI [-7.91, 0.97], t(2068) = -1.53, p = 0.126; Std.
## beta = -0.37, 95% CI [-0.85, 0.10])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-1.78, 3.65], t(2068) = 0.68, p = 0.498; Std.
## beta = 0.10, 95% CI [-0.19, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-1.74, 12.34], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.57, 95% CI [-0.19, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-3.81, 1.46], t(2068) = -0.87, p = 0.382; Std.
## beta = -0.13, 95% CI [-0.41, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-1.99, 4.69], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.15, 95% CI [-0.21, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.74, 95% CI [-6.47, 19.95], t(2068) = 1.00, p = 0.317; Std.
## beta = 0.72, 95% CI [-0.70, 2.14])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.52, 95% CI [-0.77, 11.80], t(2068) = 1.72, p = 0.085; Std.
## beta = 0.59, 95% CI [-0.08, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-3.46, 7.77], t(2068) = 0.75, p = 0.452; Std.
## beta = 0.23, 95% CI [-0.37, 0.83])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-9.44, 6.91], t(2068) = -0.30, p = 0.761; Std.
## beta = -0.14, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-10.75, 5.27], t(2068) = -0.67, p = 0.503; Std.
## beta = -0.29, 95% CI [-1.15, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-34.31, 39.88], t(2068) = 0.15, p = 0.883; Std.
## beta = 0.30, 95% CI [-3.69, 4.28])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-26.21, 18.46], t(2068) = -0.34, p = 0.734;
## Std. beta = -0.42, 95% CI [-2.82, 1.98])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-3.90, 6.86], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.16, 95% CI [-0.42, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.77, 95% CI [-15.38, 26.92], t(2068) = 0.53, p = 0.593; Std.
## beta = 0.62, 95% CI [-1.65, 2.89])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.34, 95% CI [-6.09, 10.78], t(2068) = 0.55, p = 0.586; Std.
## beta = 0.25, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-6.51, 6.23], t(2068) = -0.04, p = 0.966; Std.
## beta = -0.01, 95% CI [-0.70, 0.67])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-5.46, 12.46], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.38, 95% CI [-0.59, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.33, 95% CI [-9.72, 1.06], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.46, 95% CI [-1.04, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-9.28, 10.51], t(2068) = 0.12, p = 0.903; Std.
## beta = 0.07, 95% CI [-1.00, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-5.64, 3.91], t(2068) = -0.36, p = 0.722; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -7.28, 95% CI [-12.81, -1.75], t(2068) = -2.58, p = 0.010;
## Std. beta = -0.78, 95% CI [-1.38, -0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -12.34, 95% CI [-33.83, 9.15], t(2068) = -1.13, p = 0.260;
## Std. beta = -1.33, 95% CI [-3.63, 0.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-10.94, 7.83], t(2068) = -0.32, p = 0.745; Std.
## beta = -0.17, 95% CI [-1.18, 0.84])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.18, 95% CI [-4.34, 3.98], t(2068) = -0.09, p = 0.932; Std.
## beta = -0.02, 95% CI [-0.47, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.97, 95% CI [-11.62, 1.67], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.53, 95% CI [-1.25, 0.18])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-5.48, 9.80], t(2068) = 0.56, p = 0.579; Std.
## beta = 0.23, 95% CI [-0.59, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.15, 3.47], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.14, 95% CI [-0.66, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.79, 95% CI [2.50, 19.08], t(2068) = 2.55, p = 0.011; Std.
## beta = 1.16, 95% CI [0.27, 2.05])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-3.11, 8.23], t(2068) = 0.89, p = 0.375; Std.
## beta = 0.28, 95% CI [-0.33, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -3.12, 95% CI [-8.63, 2.39], t(2068) = -1.11, p = 0.266; Std.
## beta = -0.34, 95% CI [-0.93, 0.26])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.94, 95% CI [-7.93, 0.05], t(2068) = -1.94, p = 0.053; Std.
## beta = -0.42, 95% CI [-0.85, 5.04e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-63.91, -30.25], t(2068) = -5.49, p < .001;
## Std. beta = -5.06, 95% CI [-6.87, -3.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-9.75, 7.86], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.10, 95% CI [-1.05, 0.84])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-10.59, 11.25], t(2068) = 0.06, p = 0.953; Std.
## beta = 0.04, 95% CI [-1.14, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-10.02, 11.17], t(2068) = 0.11, p = 0.916; Std.
## beta = 0.06, 95% CI [-1.08, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.20. The model's intercept, corresponding to site =
## Simmons, is at 70.37 (95% CI [63.48, 77.25], t(2068) = 20.04, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.04, 95% CI [-5.43, -0.64], t(2068) = -2.49, p = 0.013; Std. beta = -0.39,
## 95% CI [-0.54, -0.25])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.87, 95% CI [-12.53, -3.21], t(2068) = -3.31, p < .001; Std. beta =
## -0.32, 95% CI [-0.50, -0.15])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -16.53, 95% CI [-49.56, 16.51], t(2068) = -0.98, p = 0.327; Std. beta =
## -2.40, 95% CI [-5.20, 0.39])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.89, 95% CI [-19.09, 28.87], t(2068) = 0.40, p = 0.689; Std. beta = 0.35,
## 95% CI [-1.08, 1.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.77, 95% CI [-25.84, 20.30], t(2068) = -0.24, p = 0.814; Std. beta = -0.68,
## 95% CI [-2.19, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -17.52, 95% CI [-36.72, 1.69], t(2068) = -1.79, p = 0.074; Std. beta = -1.17,
## 95% CI [-2.55, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 13.66, 95% CI [-9.83, 37.15], t(2068) = 1.14, p = 0.254; Std. beta = 0.47,
## 95% CI [-1.02, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-3.97, 16.02], t(2068) = 1.18, p = 0.237; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 13.74, 95% CI [-9.67, 37.16], t(2068) = 1.15, p = 0.250; Std. beta = 0.17,
## 95% CI [-1.30, 1.63])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -4.21, 95% CI [-11.84, 3.41], t(2068) = -1.08, p = 0.279; Std. beta = -0.38,
## 95% CI [-0.85, 0.09])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.84, 95% CI [-11.60, 15.28], t(2068) = 0.27, p = 0.789; Std. beta = -0.20,
## 95% CI [-1.01, 0.61])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.80, 95% CI [-18.67, -2.93], t(2068) = -2.69, p = 0.007; Std. beta = -0.55,
## 95% CI [-1.04, -0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.49, 95% CI [-29.33, -1.65], t(2068) = -2.20, p = 0.028; Std. beta = -0.44,
## 95% CI [-1.39, 0.50])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-11.48, 4.17], t(2068) = -0.92, p = 0.360; Std. beta = -0.32,
## 95% CI [-0.80, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.15, 95% CI [-19.09, -1.20], t(2068) = -2.23, p = 0.026; Std. beta = -0.48,
## 95% CI [-1.02, 0.07])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-36.70, 10.52], t(2068) = -1.09, p = 0.277; Std. beta =
## -0.17, 95% CI [-1.76, 1.42])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-29.25, 9.75], t(2068) = -0.98, p = 0.327; Std. beta = -0.08,
## 95% CI [-1.25, 1.08])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.62, 95% CI [-31.51, 36.75], t(2068) = 0.15, p = 0.880; Std. beta = 0.15,
## 95% CI [-1.86, 2.17])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.34, 95% CI [-9.98, 20.65], t(2068) = 0.68, p = 0.494; Std. beta = 0.51, 95%
## CI [-0.45, 1.46])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 2.80, 95% CI [-20.66, 26.26], t(2068) = 0.23, p = 0.815; Std. beta = 0.05,
## 95% CI [-1.42, 1.52])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 8.66, 95% CI [-9.08, 26.40], t(2068) = 0.96, p = 0.339; Std. beta = 0.27, 95%
## CI [-0.82, 1.35])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-30.26, 28.78], t(2068) = -0.05, p = 0.961; Std. beta = 0.20,
## 95% CI [-2.41, 2.82])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.68, 95% CI [-69.80, -3.56], t(2068) = -2.17, p = 0.030; Std. beta = -2.51,
## 95% CI [-4.89, -0.13])
## - The effect of site [16R] is statistically significant and negative (beta =
## -22.45, 95% CI [-37.63, -7.27], t(2068) = -2.90, p = 0.004; Std. beta = -1.19,
## 95% CI [-2.14, -0.24])
## - The effect of site [17R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-34.19, 31.72], t(2068) = -0.07, p = 0.941; Std. beta = -0.07,
## 95% CI [-2.02, 1.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2068) = -0.67, p = 0.500; Std. beta = 0.03,
## 95% CI [-2.09, 2.16])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.72, 95% CI [-17.64, 14.20], t(2068) = -0.21, p = 0.832; Std. beta = 0.11,
## 95% CI [-0.97, 1.19])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.02, 95% CI [-18.23, 10.20], t(2068) = -0.55, p = 0.580; Std. beta = -0.25,
## 95% CI [-1.16, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -4.68, 95% CI [-36.89, 27.54], t(2068) = -0.28, p = 0.776; Std. beta = 0.04,
## 95% CI [-1.87, 1.94])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-15.79, 5.92], t(2068) = -0.89, p = 0.373; Std. beta = -0.68,
## 95% CI [-1.39, 0.04])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.80, -2.89], t(2068) = -2.33, p = 0.020; Std. beta = -1.03,
## 95% CI [-2.19, 0.13])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-14.74, 11.61], t(2068) = -0.23, p = 0.816; Std. beta = -0.17,
## 95% CI [-0.98, 0.64])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-20.40, 8.09], t(2068) = -0.85, p = 0.397; Std. beta = -1.01,
## 95% CI [-1.89, -0.13])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -5.15, 95% CI [-24.43, 14.14], t(2068) = -0.52, p = 0.601; Std. beta = -1.40,
## 95% CI [-3.47, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-45.75, 19.88], t(2068) = -0.77, p = 0.440; Std. beta =
## -0.90, 95% CI [-2.82, 1.02])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.47, 95% CI [-19.77, 10.82], t(2068) = -0.57, p = 0.566; Std. beta = -0.28,
## 95% CI [-1.19, 0.63])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.66, 95% CI [-14.55, 19.88], t(2068) = 0.30, p = 0.762; Std. beta = -0.29,
## 95% CI [-1.36, 0.79])
## - The effect of site [33R] is statistically significant and negative (beta =
## -23.13, 95% CI [-39.95, -6.31], t(2068) = -2.70, p = 0.007; Std. beta = -1.17,
## 95% CI [-2.29, -0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-17.98, 8.23], t(2068) = -0.73, p = 0.466; Std. beta = -0.41,
## 95% CI [-1.21, 0.40])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-23.09, 16.32], t(2068) = -0.34, p = 0.736; Std. beta = 0.76,
## 95% CI [-0.47, 2.00])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.00, -3.84], t(2068) = -2.46, p = 0.014; Std. beta = -0.89,
## 95% CI [-1.84, 0.06])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-10.91, 22.44], t(2068) = 0.68, p = 0.498; Std. beta = 0.06,
## 95% CI [-0.95, 1.07])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.36, 15.85], t(2068) = 0.61, p = 0.544; Std. beta = -0.13,
## 95% CI [-0.87, 0.60])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.48, 95% CI [-23.30, 42.26], t(2068) = 0.57, p = 0.571; Std. beta = -3.64,
## 95% CI [-5.79, -1.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 22.87, 95% CI [-0.21, 45.94], t(2068) = 1.94, p = 0.052; Std. beta = 1.26,
## 95% CI [-0.21, 2.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-28.00, 10.69], t(2068) = -0.88, p = 0.380; Std. beta = -0.48,
## 95% CI [-1.81, 0.85])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.78, 95% CI [-17.57, 4.01], t(2068) = -1.23, p = 0.218; Std. beta = -0.35,
## 95% CI [-1.33, 0.63])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.83, 95% CI [-2.51, 0.85], t(2068) =
## -0.97, p = 0.331; Std. beta = -0.05, 95% CI [-0.16, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -16.01, 95% CI [-44.92, 12.90], t(2068) = -1.09, p = 0.278;
## Std. beta = -1.72, 95% CI [-4.83, 1.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-9.32, 10.65], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-1.00, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.75, 95% CI [-16.60, 5.11], t(2068) = -1.04, p = 0.299; Std.
## beta = -0.62, 95% CI [-1.78, 0.55])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-13.78, 10.68], t(2068) = -0.25, p = 0.803;
## Std. beta = -0.17, 95% CI [-1.48, 1.15])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.72, 95% CI [-13.17, 5.72], t(2068) = -0.77, p = 0.439; Std.
## beta = -0.40, 95% CI [-1.41, 0.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.61, 95% CI [-7.64, -1.58], t(2068) = -2.98, p = 0.003; Std.
## beta = -0.50, 95% CI [-0.82, -0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.23, 95% CI [-15.64, 1.19], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.78, 95% CI [-1.68, 0.13])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.46, 95% CI [-3.99, 1.07], t(2068) = -1.13, p = 0.258; Std.
## beta = -0.16, 95% CI [-0.43, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.47, 95% CI [-7.91, 0.97], t(2068) = -1.53, p = 0.126; Std.
## beta = -0.37, 95% CI [-0.85, 0.10])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-1.78, 3.65], t(2068) = 0.68, p = 0.498; Std.
## beta = 0.10, 95% CI [-0.19, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-1.74, 12.34], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.57, 95% CI [-0.19, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-3.81, 1.46], t(2068) = -0.87, p = 0.382; Std.
## beta = -0.13, 95% CI [-0.41, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-1.99, 4.69], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.15, 95% CI [-0.21, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.74, 95% CI [-6.47, 19.95], t(2068) = 1.00, p = 0.317; Std.
## beta = 0.72, 95% CI [-0.70, 2.14])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.52, 95% CI [-0.77, 11.80], t(2068) = 1.72, p = 0.085; Std.
## beta = 0.59, 95% CI [-0.08, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-3.46, 7.77], t(2068) = 0.75, p = 0.452; Std.
## beta = 0.23, 95% CI [-0.37, 0.83])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-9.44, 6.91], t(2068) = -0.30, p = 0.761; Std.
## beta = -0.14, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-10.75, 5.27], t(2068) = -0.67, p = 0.503; Std.
## beta = -0.29, 95% CI [-1.15, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-34.31, 39.88], t(2068) = 0.15, p = 0.883; Std.
## beta = 0.30, 95% CI [-3.69, 4.28])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-26.21, 18.46], t(2068) = -0.34, p = 0.734;
## Std. beta = -0.42, 95% CI [-2.82, 1.98])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-3.90, 6.86], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.16, 95% CI [-0.42, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.77, 95% CI [-15.38, 26.92], t(2068) = 0.53, p = 0.593; Std.
## beta = 0.62, 95% CI [-1.65, 2.89])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.34, 95% CI [-6.09, 10.78], t(2068) = 0.55, p = 0.586; Std.
## beta = 0.25, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-6.51, 6.23], t(2068) = -0.04, p = 0.966; Std.
## beta = -0.01, 95% CI [-0.70, 0.67])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-5.46, 12.46], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.38, 95% CI [-0.59, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.33, 95% CI [-9.72, 1.06], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.46, 95% CI [-1.04, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-9.28, 10.51], t(2068) = 0.12, p = 0.903; Std.
## beta = 0.07, 95% CI [-1.00, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-5.64, 3.91], t(2068) = -0.36, p = 0.722; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -7.28, 95% CI [-12.81, -1.75], t(2068) = -2.58, p = 0.010;
## Std. beta = -0.78, 95% CI [-1.38, -0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -12.34, 95% CI [-33.83, 9.15], t(2068) = -1.13, p = 0.260;
## Std. beta = -1.33, 95% CI [-3.63, 0.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-10.94, 7.83], t(2068) = -0.32, p = 0.745; Std.
## beta = -0.17, 95% CI [-1.18, 0.84])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.18, 95% CI [-4.34, 3.98], t(2068) = -0.09, p = 0.932; Std.
## beta = -0.02, 95% CI [-0.47, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.97, 95% CI [-11.62, 1.67], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.53, 95% CI [-1.25, 0.18])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-5.48, 9.80], t(2068) = 0.56, p = 0.579; Std.
## beta = 0.23, 95% CI [-0.59, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.15, 3.47], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.14, 95% CI [-0.66, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.79, 95% CI [2.50, 19.08], t(2068) = 2.55, p = 0.011; Std.
## beta = 1.16, 95% CI [0.27, 2.05])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-3.11, 8.23], t(2068) = 0.89, p = 0.375; Std.
## beta = 0.28, 95% CI [-0.33, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -3.12, 95% CI [-8.63, 2.39], t(2068) = -1.11, p = 0.266; Std.
## beta = -0.34, 95% CI [-0.93, 0.26])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.94, 95% CI [-7.93, 0.05], t(2068) = -1.94, p = 0.053; Std.
## beta = -0.42, 95% CI [-0.85, 5.04e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-63.91, -30.25], t(2068) = -5.49, p < .001;
## Std. beta = -5.06, 95% CI [-6.87, -3.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-9.75, 7.86], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.10, 95% CI [-1.05, 0.84])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-10.59, 11.25], t(2068) = 0.06, p = 0.953; Std.
## beta = 0.04, 95% CI [-1.14, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-10.02, 11.17], t(2068) = 0.11, p = 0.916; Std.
## beta = 0.06, 95% CI [-1.08, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.20. The model's intercept,
## corresponding to cohort = CARE-PF, is at 70.37 (95% CI [63.48, 77.25], t(2068)
## = 20.04, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.04, 95% CI [-5.43, -0.64], t(2068) = -2.49, p = 0.013; Std. beta = -0.39,
## 95% CI [-0.54, -0.25])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.87, 95% CI [-12.53, -3.21], t(2068) = -3.31, p < .001; Std. beta =
## -0.32, 95% CI [-0.50, -0.15])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -16.53, 95% CI [-49.56, 16.51], t(2068) = -0.98, p = 0.327; Std. beta =
## -2.40, 95% CI [-5.20, 0.39])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 4.89, 95% CI [-19.09, 28.87], t(2068) = 0.40, p = 0.689; Std. beta = 0.35,
## 95% CI [-1.08, 1.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.77, 95% CI [-25.84, 20.30], t(2068) = -0.24, p = 0.814; Std. beta = -0.68,
## 95% CI [-2.19, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -17.52, 95% CI [-36.72, 1.69], t(2068) = -1.79, p = 0.074; Std. beta = -1.17,
## 95% CI [-2.55, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 13.66, 95% CI [-9.83, 37.15], t(2068) = 1.14, p = 0.254; Std. beta = 0.47,
## 95% CI [-1.02, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-3.97, 16.02], t(2068) = 1.18, p = 0.237; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 13.74, 95% CI [-9.67, 37.16], t(2068) = 1.15, p = 0.250; Std. beta = 0.17,
## 95% CI [-1.30, 1.63])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -4.21, 95% CI [-11.84, 3.41], t(2068) = -1.08, p = 0.279; Std. beta = -0.38,
## 95% CI [-0.85, 0.09])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.84, 95% CI [-11.60, 15.28], t(2068) = 0.27, p = 0.789; Std. beta = -0.20,
## 95% CI [-1.01, 0.61])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.80, 95% CI [-18.67, -2.93], t(2068) = -2.69, p = 0.007; Std. beta = -0.55,
## 95% CI [-1.04, -0.07])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.49, 95% CI [-29.33, -1.65], t(2068) = -2.20, p = 0.028; Std. beta = -0.44,
## 95% CI [-1.39, 0.50])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-11.48, 4.17], t(2068) = -0.92, p = 0.360; Std. beta = -0.32,
## 95% CI [-0.80, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.15, 95% CI [-19.09, -1.20], t(2068) = -2.23, p = 0.026; Std. beta = -0.48,
## 95% CI [-1.02, 0.07])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-36.70, 10.52], t(2068) = -1.09, p = 0.277; Std. beta =
## -0.17, 95% CI [-1.76, 1.42])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-29.25, 9.75], t(2068) = -0.98, p = 0.327; Std. beta = -0.08,
## 95% CI [-1.25, 1.08])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.62, 95% CI [-31.51, 36.75], t(2068) = 0.15, p = 0.880; Std. beta = 0.15,
## 95% CI [-1.86, 2.17])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 5.34, 95% CI [-9.98, 20.65], t(2068) = 0.68, p = 0.494; Std. beta = 0.51, 95%
## CI [-0.45, 1.46])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 2.80, 95% CI [-20.66, 26.26], t(2068) = 0.23, p = 0.815; Std. beta = 0.05,
## 95% CI [-1.42, 1.52])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 8.66, 95% CI [-9.08, 26.40], t(2068) = 0.96, p = 0.339; Std. beta = 0.27, 95%
## CI [-0.82, 1.35])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-30.26, 28.78], t(2068) = -0.05, p = 0.961; Std. beta = 0.20,
## 95% CI [-2.41, 2.82])
## - The effect of site [15R] is statistically significant and negative (beta =
## -36.68, 95% CI [-69.80, -3.56], t(2068) = -2.17, p = 0.030; Std. beta = -2.51,
## 95% CI [-4.89, -0.13])
## - The effect of site [16R] is statistically significant and negative (beta =
## -22.45, 95% CI [-37.63, -7.27], t(2068) = -2.90, p = 0.004; Std. beta = -1.19,
## 95% CI [-2.14, -0.24])
## - The effect of site [17R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-34.19, 31.72], t(2068) = -0.07, p = 0.941; Std. beta = -0.07,
## 95% CI [-2.02, 1.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-31.88, 15.57], t(2068) = -0.67, p = 0.500; Std. beta = 0.03,
## 95% CI [-2.09, 2.16])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.72, 95% CI [-17.64, 14.20], t(2068) = -0.21, p = 0.832; Std. beta = 0.11,
## 95% CI [-0.97, 1.19])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.02, 95% CI [-18.23, 10.20], t(2068) = -0.55, p = 0.580; Std. beta = -0.25,
## 95% CI [-1.16, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -4.68, 95% CI [-36.89, 27.54], t(2068) = -0.28, p = 0.776; Std. beta = 0.04,
## 95% CI [-1.87, 1.94])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-15.79, 5.92], t(2068) = -0.89, p = 0.373; Std. beta = -0.68,
## 95% CI [-1.39, 0.04])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.35, 95% CI [-33.80, -2.89], t(2068) = -2.33, p = 0.020; Std. beta = -1.03,
## 95% CI [-2.19, 0.13])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.57, 95% CI [-14.74, 11.61], t(2068) = -0.23, p = 0.816; Std. beta = -0.17,
## 95% CI [-0.98, 0.64])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-20.40, 8.09], t(2068) = -0.85, p = 0.397; Std. beta = -1.01,
## 95% CI [-1.89, -0.13])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -5.15, 95% CI [-24.43, 14.14], t(2068) = -0.52, p = 0.601; Std. beta = -1.40,
## 95% CI [-3.47, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-45.75, 19.88], t(2068) = -0.77, p = 0.440; Std. beta =
## -0.90, 95% CI [-2.82, 1.02])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.47, 95% CI [-19.77, 10.82], t(2068) = -0.57, p = 0.566; Std. beta = -0.28,
## 95% CI [-1.19, 0.63])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.66, 95% CI [-14.55, 19.88], t(2068) = 0.30, p = 0.762; Std. beta = -0.29,
## 95% CI [-1.36, 0.79])
## - The effect of site [33R] is statistically significant and negative (beta =
## -23.13, 95% CI [-39.95, -6.31], t(2068) = -2.70, p = 0.007; Std. beta = -1.17,
## 95% CI [-2.29, -0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-17.98, 8.23], t(2068) = -0.73, p = 0.466; Std. beta = -0.41,
## 95% CI [-1.21, 0.40])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-23.09, 16.32], t(2068) = -0.34, p = 0.736; Std. beta = 0.76,
## 95% CI [-0.47, 2.00])
## - The effect of site [36R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.00, -3.84], t(2068) = -2.46, p = 0.014; Std. beta = -0.89,
## 95% CI [-1.84, 0.06])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 5.76, 95% CI [-10.91, 22.44], t(2068) = 0.68, p = 0.498; Std. beta = 0.06,
## 95% CI [-0.95, 1.07])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.36, 15.85], t(2068) = 0.61, p = 0.544; Std. beta = -0.13,
## 95% CI [-0.87, 0.60])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 9.48, 95% CI [-23.30, 42.26], t(2068) = 0.57, p = 0.571; Std. beta = -3.64,
## 95% CI [-5.79, -1.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 22.87, 95% CI [-0.21, 45.94], t(2068) = 1.94, p = 0.052; Std. beta = 1.26,
## 95% CI [-0.21, 2.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-28.00, 10.69], t(2068) = -0.88, p = 0.380; Std. beta = -0.48,
## 95% CI [-1.81, 0.85])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.78, 95% CI [-17.57, 4.01], t(2068) = -1.23, p = 0.218; Std. beta = -0.35,
## 95% CI [-1.33, 0.63])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -0.83, 95% CI [-2.51, 0.85], t(2068) =
## -0.97, p = 0.331; Std. beta = -0.05, 95% CI [-0.16, 0.05])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -16.01, 95% CI [-44.92, 12.90], t(2068) = -1.09, p = 0.278;
## Std. beta = -1.72, 95% CI [-4.83, 1.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-9.32, 10.65], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-1.00, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.75, 95% CI [-16.60, 5.11], t(2068) = -1.04, p = 0.299; Std.
## beta = -0.62, 95% CI [-1.78, 0.55])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-13.78, 10.68], t(2068) = -0.25, p = 0.803;
## Std. beta = -0.17, 95% CI [-1.48, 1.15])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.72, 95% CI [-13.17, 5.72], t(2068) = -0.77, p = 0.439; Std.
## beta = -0.40, 95% CI [-1.41, 0.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.61, 95% CI [-7.64, -1.58], t(2068) = -2.98, p = 0.003; Std.
## beta = -0.50, 95% CI [-0.82, -0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.23, 95% CI [-15.64, 1.19], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.78, 95% CI [-1.68, 0.13])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.46, 95% CI [-3.99, 1.07], t(2068) = -1.13, p = 0.258; Std.
## beta = -0.16, 95% CI [-0.43, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.47, 95% CI [-7.91, 0.97], t(2068) = -1.53, p = 0.126; Std.
## beta = -0.37, 95% CI [-0.85, 0.10])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-1.78, 3.65], t(2068) = 0.68, p = 0.498; Std.
## beta = 0.10, 95% CI [-0.19, 0.39])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-1.74, 12.34], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.57, 95% CI [-0.19, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-3.81, 1.46], t(2068) = -0.87, p = 0.382; Std.
## beta = -0.13, 95% CI [-0.41, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-1.99, 4.69], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.15, 95% CI [-0.21, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.74, 95% CI [-6.47, 19.95], t(2068) = 1.00, p = 0.317; Std.
## beta = 0.72, 95% CI [-0.70, 2.14])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.52, 95% CI [-0.77, 11.80], t(2068) = 1.72, p = 0.085; Std.
## beta = 0.59, 95% CI [-0.08, 1.27])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-3.46, 7.77], t(2068) = 0.75, p = 0.452; Std.
## beta = 0.23, 95% CI [-0.37, 0.83])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-9.44, 6.91], t(2068) = -0.30, p = 0.761; Std.
## beta = -0.14, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-10.75, 5.27], t(2068) = -0.67, p = 0.503; Std.
## beta = -0.29, 95% CI [-1.15, 0.57])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.78, 95% CI [-34.31, 39.88], t(2068) = 0.15, p = 0.883; Std.
## beta = 0.30, 95% CI [-3.69, 4.28])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-26.21, 18.46], t(2068) = -0.34, p = 0.734;
## Std. beta = -0.42, 95% CI [-2.82, 1.98])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-3.90, 6.86], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.16, 95% CI [-0.42, 0.74])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 5.77, 95% CI [-15.38, 26.92], t(2068) = 0.53, p = 0.593; Std.
## beta = 0.62, 95% CI [-1.65, 2.89])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.34, 95% CI [-6.09, 10.78], t(2068) = 0.55, p = 0.586; Std.
## beta = 0.25, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-6.51, 6.23], t(2068) = -0.04, p = 0.966; Std.
## beta = -0.01, 95% CI [-0.70, 0.67])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-5.46, 12.46], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.38, 95% CI [-0.59, 1.34])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -4.33, 95% CI [-9.72, 1.06], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.46, 95% CI [-1.04, 0.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-9.28, 10.51], t(2068) = 0.12, p = 0.903; Std.
## beta = 0.07, 95% CI [-1.00, 1.13])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-5.64, 3.91], t(2068) = -0.36, p = 0.722; Std.
## beta = -0.09, 95% CI [-0.61, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -7.28, 95% CI [-12.81, -1.75], t(2068) = -2.58, p = 0.010;
## Std. beta = -0.78, 95% CI [-1.38, -0.19])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -12.34, 95% CI [-33.83, 9.15], t(2068) = -1.13, p = 0.260;
## Std. beta = -1.33, 95% CI [-3.63, 0.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.55, 95% CI [-10.94, 7.83], t(2068) = -0.32, p = 0.745; Std.
## beta = -0.17, 95% CI [-1.18, 0.84])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.18, 95% CI [-4.34, 3.98], t(2068) = -0.09, p = 0.932; Std.
## beta = -0.02, 95% CI [-0.47, 0.43])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.97, 95% CI [-11.62, 1.67], t(2068) = -1.47, p = 0.142; Std.
## beta = -0.53, 95% CI [-1.25, 0.18])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.16, 95% CI [-5.48, 9.80], t(2068) = 0.56, p = 0.579; Std.
## beta = 0.23, 95% CI [-0.59, 1.05])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.15, 3.47], t(2068) = -0.55, p = 0.585; Std.
## beta = -0.14, 95% CI [-0.66, 0.37])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.79, 95% CI [2.50, 19.08], t(2068) = 2.55, p = 0.011; Std.
## beta = 1.16, 95% CI [0.27, 2.05])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.56, 95% CI [-3.11, 8.23], t(2068) = 0.89, p = 0.375; Std.
## beta = 0.28, 95% CI [-0.33, 0.88])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -3.12, 95% CI [-8.63, 2.39], t(2068) = -1.11, p = 0.266; Std.
## beta = -0.34, 95% CI [-0.93, 0.26])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.94, 95% CI [-7.93, 0.05], t(2068) = -1.94, p = 0.053; Std.
## beta = -0.42, 95% CI [-0.85, 5.04e-03])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.08, 95% CI [-63.91, -30.25], t(2068) = -5.49, p < .001;
## Std. beta = -5.06, 95% CI [-6.87, -3.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-9.75, 7.86], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.10, 95% CI [-1.05, 0.84])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-10.59, 11.25], t(2068) = 0.06, p = 0.953; Std.
## beta = 0.04, 95% CI [-1.14, 1.21])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-10.02, 11.17], t(2068) = 0.11, p = 0.916; Std.
## beta = 0.06, 95% CI [-1.08, 1.20])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*NH4_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14360.4
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2880 -0.4408 -0.0203 0.4465 4.4790
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 228.27 15.109
## time_firstPFT 13.57 3.684 -0.10
## Residual 25.61 5.060
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 41.63718 6.74398 6.174
## time_firstPFT 0.08279 2.50876 0.033
## NH4_5yrPreCensor -7.19526 2.36958 -3.037
## disadv 2.73953 2.88515 0.950
## dich_RaceNon-White -6.35301 2.78788 -2.279
## sexF 4.09422 1.72983 2.367
## age_dx 0.39361 0.09024 4.362
## smokeHxFormer 3.83332 1.71442 2.236
## smokeHxAlways 18.75177 8.33744 2.249
## smokeHxUnknown -0.55274 3.94422 -0.140
## site02R -19.51931 16.26345 -1.200
## site03R 3.69124 11.90496 0.310
## site04R -2.29811 11.28271 -0.204
## site05R -18.16448 9.43895 -1.924
## site06R 5.15472 16.09996 0.320
## site07R 5.66001 4.93117 1.148
## site09R 12.97293 11.53230 1.125
## site101 -2.37491 3.78391 -0.628
## site102 3.82455 6.69994 0.571
## site103 -10.38037 4.01672 -2.584
## site104 -16.15359 6.83564 -2.363
## site105 -2.88789 3.87177 -0.746
## site106 -11.39140 4.49048 -2.537
## site107 -9.63007 11.61117 -0.829
## site108 -4.73838 10.01475 -0.473
## site10R 0.43499 17.01692 0.026
## site11R 2.87359 7.50431 0.383
## site12R -0.67290 11.48875 -0.059
## site13R 10.69094 8.78387 1.217
## site14R -1.30617 14.72733 -0.089
## site15R -42.15047 16.27611 -2.590
## site16R -15.98379 7.57108 -2.111
## site17R 3.44967 16.30750 0.212
## site18R -10.56546 11.63498 -0.908
## site19R -1.24868 7.87239 -0.159
## site20R -4.76425 7.00208 -0.680
## site21R -4.99624 15.72718 -0.318
## site22R -8.30805 5.43234 -1.529
## site23R -20.45096 9.04994 -2.260
## site24R -2.01516 6.47031 -0.311
## site25R -6.62519 7.10284 -0.933
## site28R -1.03705 9.50675 -0.109
## site29R -15.04310 16.14718 -0.932
## site31R -2.92620 7.63477 -0.383
## site32R 0.79071 8.49875 0.093
## site33R -20.78402 8.27466 -2.512
## site34R -6.59457 6.42953 -1.026
## site35R -9.00967 9.71273 -0.928
## site36R -17.10337 7.41011 -2.308
## site37R 9.12974 8.26938 1.104
## site38R 4.49080 5.94569 0.755
## site39R 14.68586 16.36668 0.897
## site40R 21.00513 11.30083 1.859
## site41R -10.52863 9.58433 -1.099
## site42R -6.84573 5.37697 -1.273
## time_firstPFT:NH4_5yrPreCensor -1.08012 0.92550 -1.167
## time_firstPFT:disadv -0.17727 1.11696 -0.159
## time_firstPFT:dich_RaceNon-White 0.27846 1.12267 0.248
## time_firstPFT:sexF 0.06194 0.66095 0.094
## time_firstPFT:age_dx -0.05811 0.03463 -1.678
## time_firstPFT:smokeHxFormer 0.50334 0.67376 0.747
## time_firstPFT:smokeHxAlways 1.34951 5.28830 0.255
## time_firstPFT:smokeHxUnknown 2.07694 1.71176 1.213
## time_firstPFT:site02R -15.48712 14.79382 -1.047
## time_firstPFT:site03R 1.73513 5.19102 0.334
## time_firstPFT:site04R -5.37918 5.61996 -0.957
## time_firstPFT:site05R -1.45095 6.28610 -0.231
## time_firstPFT:site07R -4.22176 1.61570 -2.613
## time_firstPFT:site09R -7.19124 4.39459 -1.636
## time_firstPFT:site101 -1.42764 1.32678 -1.076
## time_firstPFT:site102 -3.78597 2.35007 -1.611
## time_firstPFT:site103 0.87811 1.48484 0.591
## time_firstPFT:site104 5.55052 3.68086 1.508
## time_firstPFT:site105 -1.29229 1.38291 -0.934
## time_firstPFT:site106 1.81477 1.78512 1.017
## time_firstPFT:site107 6.64368 6.78648 0.979
## time_firstPFT:site108 5.15366 3.47695 1.482
## time_firstPFT:site11R 2.83973 2.96629 0.957
## time_firstPFT:site12R -1.00168 4.26745 -0.235
## time_firstPFT:site13R -2.37890 4.17824 -0.569
## time_firstPFT:site14R 3.07589 18.95129 0.162
## time_firstPFT:site15R -3.80923 11.43877 -0.333
## time_firstPFT:site16R 1.04043 2.85807 0.364
## time_firstPFT:site18R 6.14379 10.82417 0.568
## time_firstPFT:site19R 3.39634 4.42262 0.768
## time_firstPFT:site20R 0.44466 3.34939 0.133
## time_firstPFT:site21R 3.51313 4.64629 0.756
## time_firstPFT:site22R -3.55856 2.83787 -1.254
## time_firstPFT:site23R 7.15994 24.64226 0.291
## time_firstPFT:site24R -0.92585 2.47648 -0.374
## time_firstPFT:site25R -6.72777 2.92983 -2.296
## time_firstPFT:site28R -10.93788 11.07807 -0.987
## time_firstPFT:site29R -1.16633 4.91728 -0.237
## time_firstPFT:site31R -0.31792 2.24839 -0.141
## time_firstPFT:site32R -4.49037 3.47874 -1.291
## time_firstPFT:site33R 2.64759 4.00939 0.660
## time_firstPFT:site34R -1.26720 2.51036 -0.505
## time_firstPFT:site35R 11.58485 4.31261 2.686
## time_firstPFT:site36R 2.80224 2.95487 0.948
## time_firstPFT:site37R -2.58539 2.96677 -0.871
## time_firstPFT:site38R -3.89877 2.08774 -1.867
## time_firstPFT:site39R -47.92751 8.72691 -5.492
## time_firstPFT:site40R 0.07198 4.61576 0.016
## time_firstPFT:site41R 0.95746 5.62760 0.170
## time_firstPFT:site42R 1.42914 5.42795 0.263##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.918
## Unadjusted ICC: 0.698report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## NH4_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.24. The model's intercept,
## corresponding to time_firstPFT = 0, is at 41.64 (95% CI [28.41, 54.86], t(2038)
## = 6.17, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## NH4_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to
## NH4_5yrPreCensor = 0, is at 41.64 (95% CI [28.41, 54.86], t(2038) = 6.17, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to disadv = 0, is at 41.64 (95% CI [28.41,
## 54.86], t(2038) = 6.17, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to dich_Race =
## White, is at 41.64 (95% CI [28.41, 54.86], t(2038) = 6.17, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to sex = M, is at 41.64 (95% CI [28.41,
## 54.86], t(2038) = 6.17, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to age_dx = 0, is at 41.64 (95% CI [28.41,
## 54.86], t(2038) = 6.17, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to smokeHx =
## Never, is at 41.64 (95% CI [28.41, 54.86], t(2038) = 6.17, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.24. The
## model's intercept, corresponding to site = Simmons, is at 41.64 (95% CI [28.41,
## 54.86], t(2038) = 6.17, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.24. The model's intercept, corresponding to cohort =
## CARE-PF, is at 41.64 (95% CI [28.41, 54.86], t(2038) = 6.17, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and positive
## (beta = 0.08, 95% CI [-4.84, 5.00], t(2038) = 0.03, p = 0.974; Std. beta =
## -0.45, 95% CI [-0.65, -0.26])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -7.20, 95% CI [-11.84, -2.55], t(2038) = -3.04, p = 0.002; Std. beta =
## -0.31, 95% CI [-0.49, -0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 2.74, 95% CI [-2.92, 8.40], t(2038) = 0.95, p = 0.342; Std. beta = 0.04, 95% CI
## [-0.06, 0.14])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -6.35, 95% CI [-11.82, -0.89], t(2038) = -2.28, p = 0.023; Std. beta =
## -0.35, 95% CI [-0.70, -3.02e-04])
## - The effect of sex [F] is statistically significant and positive (beta = 4.09,
## 95% CI [0.70, 7.49], t(2038) = 2.37, p = 0.018; Std. beta = 0.25, 95% CI [0.03,
## 0.46])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.22, 0.57], t(2038) = 4.36, p < .001; Std. beta = 0.17, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.83, 95% CI [0.47, 7.20], t(2038) = 2.24, p = 0.025; Std. beta = 0.27,
## 95% CI [0.06, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.75, 95% CI [2.40, 35.10], t(2038) = 2.25, p = 0.025; Std. beta =
## 1.23, 95% CI [0.03, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -0.55, 95% CI [-8.29, 7.18], t(2038) = -0.14, p = 0.889; Std. beta =
## 0.15, 95% CI [-0.35, 0.66])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -19.52, 95% CI [-51.41, 12.38], t(2038) = -1.20, p = 0.230; Std. beta =
## -2.54, 95% CI [-5.31, 0.24])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 3.69, 95% CI [-19.66, 27.04], t(2038) = 0.31, p = 0.757; Std. beta = 0.37,
## 95% CI [-1.04, 1.79])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-24.42, 19.83], t(2038) = -0.20, p = 0.839; Std. beta = -0.62,
## 95% CI [-2.10, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -18.16, 95% CI [-36.68, 0.35], t(2038) = -1.92, p = 0.054; Std. beta = -1.20,
## 95% CI [-2.57, 0.17])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.15, 95% CI [-26.42, 36.73], t(2038) = 0.32, p = 0.749; Std. beta = 0.30,
## 95% CI [-1.56, 2.17])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-4.01, 15.33], t(2038) = 1.15, p = 0.251; Std. beta = -0.04,
## 95% CI [-0.64, 0.55])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 12.97, 95% CI [-9.64, 35.59], t(2038) = 1.12, p = 0.261; Std. beta = 0.12,
## 95% CI [-1.32, 1.57])
## - The effect of site [101] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-9.80, 5.05], t(2038) = -0.63, p = 0.530; Std. beta = -0.27,
## 95% CI [-0.73, 0.20])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.82, 95% CI [-9.31, 16.96], t(2038) = 0.57, p = 0.568; Std. beta = -0.11,
## 95% CI [-0.92, 0.70])
## - The effect of site [103] is statistically significant and negative (beta =
## -10.38, 95% CI [-18.26, -2.50], t(2038) = -2.58, p = 0.010; Std. beta = -0.53,
## 95% CI [-1.03, -0.04])
## - The effect of site [104] is statistically significant and negative (beta =
## -16.15, 95% CI [-29.56, -2.75], t(2038) = -2.36, p = 0.018; Std. beta = -0.46,
## 95% CI [-1.40, 0.48])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.89, 95% CI [-10.48, 4.71], t(2038) = -0.75, p = 0.456; Std. beta = -0.29,
## 95% CI [-0.76, 0.19])
## - The effect of site [106] is statistically significant and negative (beta =
## -11.39, 95% CI [-20.20, -2.58], t(2038) = -2.54, p = 0.011; Std. beta = -0.51,
## 95% CI [-1.06, 0.04])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-32.40, 13.14], t(2038) = -0.83, p = 0.407; Std. beta = 0.03,
## 95% CI [-1.54, 1.59])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-24.38, 14.90], t(2038) = -0.47, p = 0.636; Std. beta = 0.18,
## 95% CI [-1.02, 1.38])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-32.94, 33.81], t(2038) = 0.03, p = 0.980; Std. beta = 0.03,
## 95% CI [-1.94, 1.99])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-11.84, 17.59], t(2038) = 0.38, p = 0.702; Std. beta = 0.42,
## 95% CI [-0.51, 1.36])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -0.67, 95% CI [-23.20, 21.86], t(2038) = -0.06, p = 0.953; Std. beta = -0.13,
## 95% CI [-1.57, 1.31])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.54, 27.92], t(2038) = 1.22, p = 0.224; Std. beta = 0.42,
## 95% CI [-0.66, 1.49])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-30.19, 27.58], t(2038) = -0.09, p = 0.929; Std. beta = 0.20,
## 95% CI [-2.41, 2.81])
## - The effect of site [15R] is statistically significant and negative (beta =
## -42.15, 95% CI [-74.07, -10.23], t(2038) = -2.59, p = 0.010; Std. beta = -2.83,
## 95% CI [-5.18, -0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.98, 95% CI [-30.83, -1.14], t(2038) = -2.11, p = 0.035; Std. beta = -0.85,
## 95% CI [-1.80, 0.10])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 3.45, 95% CI [-28.53, 35.43], t(2038) = 0.21, p = 0.832; Std. beta = 0.20,
## 95% CI [-1.68, 2.09])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.57, 95% CI [-33.38, 12.25], t(2038) = -0.91, p = 0.364; Std. beta =
## -0.07, 95% CI [-2.18, 2.04])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.25, 95% CI [-16.69, 14.19], t(2038) = -0.16, p = 0.874; Std. beta = 0.23,
## 95% CI [-0.85, 1.31])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-18.50, 8.97], t(2038) = -0.68, p = 0.496; Std. beta = -0.24,
## 95% CI [-1.15, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-35.84, 25.85], t(2038) = -0.32, p = 0.751; Std. beta = 0.02,
## 95% CI [-1.83, 1.87])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -8.31, 95% CI [-18.96, 2.35], t(2038) = -1.53, p = 0.126; Std. beta = -0.81,
## 95% CI [-1.52, -0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.45, 95% CI [-38.20, -2.70], t(2038) = -2.26, p = 0.024; Std. beta = -0.57,
## 95% CI [-4.62, 3.49])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-14.70, 10.67], t(2038) = -0.31, p = 0.755; Std. beta = -0.20,
## 95% CI [-0.99, 0.59])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-20.55, 7.30], t(2038) = -0.93, p = 0.351; Std. beta = -0.99,
## 95% CI [-1.87, -0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-19.68, 17.61], t(2038) = -0.11, p = 0.913; Std. beta = -1.04,
## 95% CI [-3.12, 1.04])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -15.04, 95% CI [-46.71, 16.62], t(2038) = -0.93, p = 0.352; Std. beta =
## -0.99, 95% CI [-2.87, 0.89])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-17.90, 12.05], t(2038) = -0.38, p = 0.702; Std. beta = -0.20,
## 95% CI [-1.11, 0.70])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-15.88, 17.46], t(2038) = 0.09, p = 0.926; Std. beta = -0.36,
## 95% CI [-1.42, 0.71])
## - The effect of site [33R] is statistically significant and negative (beta =
## -20.78, 95% CI [-37.01, -4.56], t(2038) = -2.51, p = 0.012; Std. beta = -0.99,
## 95% CI [-2.09, 0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.59, 95% CI [-19.20, 6.01], t(2038) = -1.03, p = 0.305; Std. beta = -0.50,
## 95% CI [-1.29, 0.29])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-28.06, 10.04], t(2038) = -0.93, p = 0.354; Std. beta = 0.51,
## 95% CI [-0.71, 1.72])
## - The effect of site [36R] is statistically significant and negative (beta =
## -17.10, 95% CI [-31.64, -2.57], t(2038) = -2.31, p = 0.021; Std. beta = -0.76,
## 95% CI [-1.69, 0.18])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 9.13, 95% CI [-7.09, 25.35], t(2038) = 1.10, p = 0.270; Std. beta = 0.31, 95%
## CI [-0.69, 1.31])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-7.17, 16.15], t(2038) = 0.76, p = 0.450; Std. beta = -0.08,
## 95% CI [-0.81, 0.64])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.69, 95% CI [-17.41, 46.78], t(2038) = 0.90, p = 0.370; Std. beta = -3.42,
## 95% CI [-5.57, -1.28])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 21.01, 95% CI [-1.16, 43.17], t(2038) = 1.86, p = 0.063; Std. beta = 1.25,
## 95% CI [-0.20, 2.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-29.32, 8.27], t(2038) = -1.10, p = 0.272; Std. beta = -0.54,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-17.39, 3.70], t(2038) = -1.27, p = 0.203; Std. beta = -0.28,
## 95% CI [-1.26, 0.71])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and negative (beta = -1.08, 95% CI [-2.90, 0.73], t(2038) =
## -1.17, p = 0.243; Std. beta = -0.07, 95% CI [-0.19, 0.05])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.18, 95% CI [-2.37, 2.01], t(2038) = -0.16, p = 0.874; Std.
## beta = -5.43e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.28, 95% CI [-1.92, 2.48], t(2038) =
## 0.25, p = 0.804; Std. beta = 0.03, 95% CI [-0.21, 0.27])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.23, 1.36], t(2038) = 0.09, p = 0.925; Std.
## beta = 6.67e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 9.80e-03], t(2038) = -1.68, p = 0.093;
## Std. beta = -0.06, 95% CI [-0.13, 9.72e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.50, 95% CI [-0.82, 1.82], t(2038) =
## 0.75, p = 0.455; Std. beta = 0.05, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.35, 95% CI [-9.02, 11.72], t(2038) =
## 0.26, p = 0.799; Std. beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.28, 5.43], t(2038) =
## 1.21, p = 0.225; Std. beta = 0.22, 95% CI [-0.14, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.49, 95% CI [-44.50, 13.53], t(2038) = -1.05, p = 0.295;
## Std. beta = -1.67, 95% CI [-4.79, 1.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-8.45, 11.92], t(2038) = 0.33, p = 0.738; Std.
## beta = 0.19, 95% CI [-0.91, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.38, 95% CI [-16.40, 5.64], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.58, 95% CI [-1.77, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.78, 10.88], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.48, 1.17])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.22, 95% CI [-7.39, -1.05], t(2038) = -2.61, p = 0.009; Std.
## beta = -0.45, 95% CI [-0.80, -0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -7.19, 95% CI [-15.81, 1.43], t(2038) = -1.64, p = 0.102; Std.
## beta = -0.77, 95% CI [-1.70, 0.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-4.03, 1.17], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.15, 95% CI [-0.43, 0.13])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.39, 0.82], t(2038) = -1.61, p = 0.107; Std.
## beta = -0.41, 95% CI [-0.90, 0.09])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-2.03, 3.79], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.09, 95% CI [-0.22, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.55, 95% CI [-1.67, 12.77], t(2038) = 1.51, p = 0.132; Std.
## beta = 0.60, 95% CI [-0.18, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-4.00, 1.42], t(2038) = -0.93, p = 0.350; Std.
## beta = -0.14, 95% CI [-0.43, 0.15])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.69, 5.32], t(2038) = 1.02, p = 0.309; Std.
## beta = 0.20, 95% CI [-0.18, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-6.67, 19.95], t(2038) = 0.98, p = 0.328; Std.
## beta = 0.72, 95% CI [-0.72, 2.15])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.15, 95% CI [-1.67, 11.97], t(2038) = 1.48, p = 0.138; Std.
## beta = 0.56, 95% CI [-0.18, 1.29])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.84, 95% CI [-2.98, 8.66], t(2038) = 0.96, p = 0.339; Std.
## beta = 0.31, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-9.37, 7.37], t(2038) = -0.23, p = 0.814; Std.
## beta = -0.11, 95% CI [-1.01, 0.79])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-10.57, 5.82], t(2038) = -0.57, p = 0.569; Std.
## beta = -0.26, 95% CI [-1.14, 0.63])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.09, 40.24], t(2038) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.67, 4.33])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.81, 95% CI [-26.24, 18.62], t(2038) = -0.33, p = 0.739;
## Std. beta = -0.41, 95% CI [-2.83, 2.01])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.04, 95% CI [-4.56, 6.65], t(2038) = 0.36, p = 0.716; Std.
## beta = 0.11, 95% CI [-0.49, 0.72])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-15.08, 27.37], t(2038) = 0.57, p = 0.570; Std.
## beta = 0.66, 95% CI [-1.62, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-5.28, 12.07], t(2038) = 0.77, p = 0.443; Std.
## beta = 0.37, 95% CI [-0.57, 1.30])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.12, 7.01], t(2038) = 0.13, p = 0.894; Std.
## beta = 0.05, 95% CI [-0.66, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 3.51, 95% CI [-5.60, 12.63], t(2038) = 0.76, p = 0.450; Std.
## beta = 0.38, 95% CI [-0.60, 1.36])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-9.12, 2.01], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.38, 95% CI [-0.98, 0.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-41.17, 55.49], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.77, 95% CI [-4.43, 5.98])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-5.78, 3.93], t(2038) = -0.37, p = 0.709; Std.
## beta = -0.10, 95% CI [-0.62, 0.42])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.73, 95% CI [-12.47, -0.98], t(2038) = -2.30, p = 0.022;
## Std. beta = -0.72, 95% CI [-1.34, -0.11])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-32.66, 10.79], t(2038) = -0.99, p = 0.324;
## Std. beta = -1.18, 95% CI [-3.52, 1.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-10.81, 8.48], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.13, 95% CI [-1.16, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-4.73, 4.09], t(2038) = -0.14, p = 0.888; Std.
## beta = -0.03, 95% CI [-0.51, 0.44])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.49, 95% CI [-11.31, 2.33], t(2038) = -1.29, p = 0.197; Std.
## beta = -0.48, 95% CI [-1.22, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.22, 10.51], t(2038) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-6.19, 3.66], t(2038) = -0.50, p = 0.614; Std.
## beta = -0.14, 95% CI [-0.67, 0.39])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.58, 95% CI [3.13, 20.04], t(2038) = 2.69, p = 0.007; Std.
## beta = 1.25, 95% CI [0.34, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-2.99, 8.60], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.30, 95% CI [-0.32, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-8.40, 3.23], t(2038) = -0.87, p = 0.384; Std.
## beta = -0.28, 95% CI [-0.91, 0.35])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.90, 95% CI [-7.99, 0.20], t(2038) = -1.87, p = 0.062; Std.
## beta = -0.42, 95% CI [-0.86, 0.02])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.93, 95% CI [-65.04, -30.81], t(2038) = -5.49, p < .001;
## Std. beta = -5.16, 95% CI [-7.00, -3.32])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-8.98, 9.12], t(2038) = 0.02, p = 0.988; Std.
## beta = 7.75e-03, 95% CI [-0.97, 0.98])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-10.08, 11.99], t(2038) = 0.17, p = 0.865; Std.
## beta = 0.10, 95% CI [-1.09, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-9.22, 12.07], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.99, 1.30])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*BC_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14560.7
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3304 -0.4393 -0.0151 0.4484 4.5283
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 257.57 16.049
## time_firstPFT 12.99 3.604 -0.11
## Residual 25.57 5.057
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 59.2406 4.4552 13.297
## time_firstPFT -3.1200 1.7053 -1.830
## BC_5yrPreCensor 0.3372 4.9353 0.068
## site02R -7.7573 16.8807 -0.460
## site03R 13.7890 12.1191 1.138
## site04R 3.3139 11.8239 0.280
## site05R -11.1273 9.7852 -1.137
## site06R 20.0750 11.9707 1.677
## site07R 12.8254 5.0089 2.560
## site09R 21.7927 11.9478 1.824
## site101 3.3287 3.7959 0.877
## site102 11.2305 6.7575 1.662
## site103 -0.7980 3.4183 -0.233
## site104 -5.3052 6.9942 -0.759
## site105 4.7260 3.7901 1.247
## site106 -3.6811 4.4370 -0.830
## site107 -4.7424 12.1407 -0.391
## site108 0.5397 10.0810 0.054
## site10R 14.0054 17.6366 0.794
## site11R 14.2191 7.4492 1.909
## site12R 11.8055 12.0593 0.979
## site13R 16.0427 8.9297 1.797
## site14R 7.0625 15.0656 0.469
## site15R -27.5595 16.8987 -1.631
## site16R -14.9509 7.5661 -1.976
## site17R 5.9524 16.9261 0.352
## site18R 0.6203 12.0182 0.052
## site19R 8.6498 8.1386 1.063
## site20R 3.7964 7.1589 0.530
## site21R 4.0827 16.4290 0.249
## site22R 1.3344 5.3642 0.249
## site23R -10.4839 7.7954 -1.345
## site24R 6.2008 6.7130 0.924
## site25R 1.8295 7.1159 0.257
## site28R 0.7452 9.8031 0.076
## site29R -3.6344 16.8034 -0.216
## site31R 4.2430 7.5552 0.562
## site32R 12.2516 8.6879 1.410
## site33R -15.5642 8.5700 -1.816
## site34R 2.5695 6.6094 0.389
## site35R 6.1962 10.0370 0.617
## site36R -12.4202 7.5678 -1.641
## site37R 12.9537 8.3687 1.548
## site38R 12.5941 5.7679 2.183
## site39R 18.8299 16.9031 1.114
## site40R 28.5807 11.7901 2.424
## site41R -0.7779 9.7300 -0.080
## site42R -0.2635 5.2840 -0.050
## time_firstPFT:BC_5yrPreCensor -1.1871 1.8952 -0.626
## time_firstPFT:site02R -15.3774 14.7212 -1.045
## time_firstPFT:site03R 1.3979 5.0186 0.279
## time_firstPFT:site04R -5.4369 5.5296 -0.983
## time_firstPFT:site05R -1.1489 6.2212 -0.185
## time_firstPFT:site06R -2.9979 4.7793 -0.627
## time_firstPFT:site07R -4.3117 1.5078 -2.860
## time_firstPFT:site09R -6.6213 4.2305 -1.565
## time_firstPFT:site101 -1.2217 1.2947 -0.944
## time_firstPFT:site102 -3.1313 2.2499 -1.392
## time_firstPFT:site103 1.4549 1.2001 1.212
## time_firstPFT:site104 5.9760 3.5038 1.706
## time_firstPFT:site105 -0.8535 1.3136 -0.650
## time_firstPFT:site106 1.6746 1.6702 1.003
## time_firstPFT:site107 7.0726 6.7379 1.050
## time_firstPFT:site108 5.7960 3.2585 1.779
## time_firstPFT:site11R 2.8914 2.7117 1.066
## time_firstPFT:site12R -0.8801 4.1573 -0.212
## time_firstPFT:site13R -2.1434 4.0347 -0.531
## time_firstPFT:site14R 2.8092 18.9169 0.149
## time_firstPFT:site15R -3.1657 11.3572 -0.279
## time_firstPFT:site16R 2.0714 2.6479 0.782
## time_firstPFT:site18R 6.3279 10.7702 0.588
## time_firstPFT:site19R 2.7031 4.2781 0.632
## time_firstPFT:site20R 0.3569 3.2180 0.111
## time_firstPFT:site21R 4.3640 4.4807 0.974
## time_firstPFT:site22R -3.8337 2.6900 -1.425
## time_firstPFT:site23R 0.9799 5.0354 0.195
## time_firstPFT:site24R -0.5384 2.4263 -0.222
## time_firstPFT:site25R -6.9447 2.8004 -2.480
## time_firstPFT:site28R -11.5321 10.9581 -1.052
## time_firstPFT:site29R -1.0425 4.7415 -0.220
## time_firstPFT:site31R 0.3890 1.9888 0.196
## time_firstPFT:site32R -4.4171 3.3073 -1.336
## time_firstPFT:site33R 2.5544 3.8943 0.656
## time_firstPFT:site34R -0.9470 2.3958 -0.395
## time_firstPFT:site35R 11.1152 4.2273 2.629
## time_firstPFT:site36R 3.0983 2.8279 1.096
## time_firstPFT:site37R -2.5420 2.7258 -0.933
## time_firstPFT:site38R -3.3402 1.8730 -1.783
## time_firstPFT:site39R -46.7813 8.5923 -5.445
## time_firstPFT:site40R -0.6516 4.5405 -0.144
## time_firstPFT:site41R 0.9716 5.5190 0.176
## time_firstPFT:site42R 0.9839 5.3919 0.182##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.924
## Unadjusted ICC: 0.730report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## BC_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.21. The model's
## intercept, corresponding to time_firstPFT = 0, is at 59.24 (95% CI [50.50,
## 67.98], t(2068) = 13.30, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.12, 95% CI [-6.46, 0.22], t(2068) = -1.83, p = 0.067; Std. beta =
## -0.42, 95% CI [-0.55, -0.29])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 0.34, 95% CI [-9.34, 10.02], t(2068) = 0.07, p = 0.946; Std. beta =
## -0.02, 95% CI [-0.17, 0.13])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.76, 95% CI [-40.86, 25.35], t(2068) = -0.46, p = 0.646; Std. beta = -1.83,
## 95% CI [-4.63, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.79, 95% CI [-9.98, 37.56], t(2068) = 1.14, p = 0.255; Std. beta = 0.94,
## 95% CI [-0.48, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-19.87, 26.50], t(2068) = 0.28, p = 0.779; Std. beta = -0.29,
## 95% CI [-1.81, 1.23])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-30.32, 8.06], t(2068) = -1.14, p = 0.256; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.07, 95% CI [-3.40, 43.55], t(2068) = 1.68, p = 0.094; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.83, 95% CI [3.00, 22.65], t(2068) = 2.56, p = 0.011; Std. beta = 0.37, 95%
## CI [-0.22, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-1.64, 45.22], t(2068) = 1.82, p = 0.068; Std. beta = 0.70,
## 95% CI [-0.78, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.12, 10.77], t(2068) = 0.88, p = 0.381; Std. beta = 0.09, 95%
## CI [-0.37, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.23, 95% CI [-2.02, 24.48], t(2068) = 1.66, p = 0.097; Std. beta = 0.38,
## 95% CI [-0.42, 1.19])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.91], t(2068) = -0.23, p = 0.815; Std. beta = 0.08,
## 95% CI [-0.33, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-19.02, 8.41], t(2068) = -0.76, p = 0.448; Std. beta = 0.22,
## 95% CI [-0.72, 1.15])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-2.71, 12.16], t(2068) = 1.25, p = 0.213; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-12.38, 5.02], t(2068) = -0.83, p = 0.407; Std. beta = -0.07,
## 95% CI [-0.60, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-28.55, 19.07], t(2068) = -0.39, p = 0.696; Std. beta = 0.35,
## 95% CI [-1.25, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.54, 95% CI [-19.23, 20.31], t(2068) = 0.05, p = 0.957; Std. beta = 0.55,
## 95% CI [-0.64, 1.74])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.01, 95% CI [-20.58, 48.59], t(2068) = 0.79, p = 0.427; Std. beta = 0.83,
## 95% CI [-1.21, 2.87])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.22, 95% CI [-0.39, 28.83], t(2068) = 1.91, p = 0.056; Std. beta = 1.10,
## 95% CI [0.18, 2.01])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.81, 95% CI [-11.84, 35.46], t(2068) = 0.98, p = 0.328; Std. beta = 0.62,
## 95% CI [-0.87, 2.11])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.04, 95% CI [-1.47, 33.55], t(2068) = 1.80, p = 0.073; Std. beta = 0.76,
## 95% CI [-0.32, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-22.48, 36.61], t(2068) = 0.47, p = 0.639; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.56, 95% CI [-60.70, 5.58], t(2068) = -1.63, p = 0.103; Std. beta = -1.91,
## 95% CI [-4.30, 0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.95, 95% CI [-29.79, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.70,
## 95% CI [-1.63, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-27.24, 39.15], t(2068) = 0.35, p = 0.725; Std. beta = 0.35,
## 95% CI [-1.61, 2.31])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.62, 95% CI [-22.95, 24.19], t(2068) = 0.05, p = 0.959; Std. beta = 0.60,
## 95% CI [-1.52, 2.72])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-7.31, 24.61], t(2068) = 1.06, p = 0.288; Std. beta = 0.75, 95%
## CI [-0.33, 1.84])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-10.24, 17.84], t(2068) = 0.53, p = 0.596; Std. beta = 0.26,
## 95% CI [-0.65, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.14, 36.30], t(2068) = 0.25, p = 0.804; Std. beta = 0.63,
## 95% CI [-1.29, 2.55])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.33, 95% CI [-9.19, 11.85], t(2068) = 0.25, p = 0.804; Std. beta = -0.26,
## 95% CI [-0.96, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.48, 95% CI [-25.77, 4.80], t(2068) = -1.34, p = 0.179; Std. beta = -0.53,
## 95% CI [-1.69, 0.62])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-6.96, 19.37], t(2068) = 0.92, p = 0.356; Std. beta = 0.32, 95%
## CI [-0.49, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.83, 95% CI [-12.13, 15.78], t(2068) = 0.26, p = 0.797; Std. beta = -0.51,
## 95% CI [-1.38, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.48, 19.97], t(2068) = 0.08, p = 0.939; Std. beta = -0.98,
## 95% CI [-3.06, 1.09])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-36.59, 29.32], t(2068) = -0.22, p = 0.829; Std. beta = -0.31,
## 95% CI [-2.24, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-10.57, 19.06], t(2068) = 0.56, p = 0.574; Std. beta = 0.28,
## 95% CI [-0.60, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-4.79, 29.29], t(2068) = 1.41, p = 0.159; Std. beta = 0.33,
## 95% CI [-0.74, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.56, 95% CI [-32.37, 1.24], t(2068) = -1.82, p = 0.069; Std. beta = -0.69,
## 95% CI [-1.81, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-10.39, 15.53], t(2068) = 0.39, p = 0.697; Std. beta = 0.07,
## 95% CI [-0.73, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-13.49, 25.88], t(2068) = 0.62, p = 0.537; Std. beta = 1.36,
## 95% CI [0.12, 2.60])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.26, 2.42], t(2068) = -1.64, p = 0.101; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.95, 95% CI [-3.46, 29.37], t(2068) = 1.55, p = 0.122; Std. beta = 0.54,
## 95% CI [-0.46, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.59, 95% CI [1.28, 23.91], t(2068) = 2.18, p = 0.029; Std. beta = 0.45, 95%
## CI [-0.24, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.83, 95% CI [-14.32, 51.98], t(2068) = 1.11, p = 0.265; Std. beta = -3.06,
## 95% CI [-5.24, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.58, 95% CI [5.46, 51.70], t(2068) = 2.42, p = 0.015; Std. beta = 1.63, 95%
## CI [0.14, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-19.86, 18.30], t(2068) = -0.08, p = 0.936; Std. beta = 0.04,
## 95% CI [-1.28, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.63, 10.10], t(2068) = -0.05, p = 0.960; Std. beta = 0.07,
## 95% CI [-0.89, 1.04])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -1.19, 95% CI [-4.90, 2.53], t(2068) =
## -0.63, p = 0.531; Std. beta = -0.03, 95% CI [-0.13, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.38, 95% CI [-44.25, 13.49], t(2068) = -1.04, p = 0.296;
## Std. beta = -1.65, 95% CI [-4.75, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-8.44, 11.24], t(2068) = 0.28, p = 0.781; Std.
## beta = 0.15, 95% CI [-0.91, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.44, 95% CI [-16.28, 5.41], t(2068) = -0.98, p = 0.326; Std.
## beta = -0.58, 95% CI [-1.75, 0.58])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-13.35, 11.05], t(2068) = -0.18, p = 0.854;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.00, 95% CI [-12.37, 6.37], t(2068) = -0.63, p = 0.531; Std.
## beta = -0.32, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.31, 95% CI [-7.27, -1.35], t(2068) = -2.86, p = 0.004; Std.
## beta = -0.46, 95% CI [-0.78, -0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.62, 95% CI [-14.92, 1.68], t(2068) = -1.57, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.22, 95% CI [-3.76, 1.32], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.13, 95% CI [-0.40, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-7.54, 1.28], t(2068) = -1.39, p = 0.164; Std.
## beta = -0.34, 95% CI [-0.81, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.45, 95% CI [-0.90, 3.81], t(2068) = 1.21, p = 0.226; Std.
## beta = 0.16, 95% CI [-0.10, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-0.90, 12.85], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.64, 95% CI [-0.10, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.43, 1.72], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.09, 95% CI [-0.37, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-1.60, 4.95], t(2068) = 1.00, p = 0.316; Std.
## beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.07, 95% CI [-6.14, 20.29], t(2068) = 1.05, p = 0.294; Std.
## beta = 0.76, 95% CI [-0.66, 2.18])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.80, 95% CI [-0.59, 12.19], t(2068) = 1.78, p = 0.075; Std.
## beta = 0.62, 95% CI [-0.06, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-2.43, 8.21], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-9.03, 7.27], t(2068) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.97, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-10.06, 5.77], t(2068) = -0.53, p = 0.595; Std.
## beta = -0.23, 95% CI [-1.08, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-34.29, 39.91], t(2068) = 0.15, p = 0.882; Std.
## beta = 0.30, 95% CI [-3.68, 4.29])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-25.44, 19.11], t(2068) = -0.28, p = 0.780;
## Std. beta = -0.34, 95% CI [-2.73, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-3.12, 7.26], t(2068) = 0.78, p = 0.434; Std.
## beta = 0.22, 95% CI [-0.34, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.33, 95% CI [-14.79, 27.45], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.68, 95% CI [-1.59, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-5.69, 11.09], t(2068) = 0.63, p = 0.528; Std.
## beta = 0.29, 95% CI [-0.61, 1.19])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-5.95, 6.67], t(2068) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.64, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-4.42, 13.15], t(2068) = 0.97, p = 0.330; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.83, 95% CI [-9.11, 1.44], t(2068) = -1.43, p = 0.154; Std.
## beta = -0.41, 95% CI [-0.98, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-8.89, 10.85], t(2068) = 0.19, p = 0.846; Std.
## beta = 0.11, 95% CI [-0.96, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-5.30, 4.22], t(2068) = -0.22, p = 0.824; Std.
## beta = -0.06, 95% CI [-0.57, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.94, 95% CI [-12.44, -1.45], t(2068) = -2.48, p = 0.013;
## Std. beta = -0.75, 95% CI [-1.34, -0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.53, 95% CI [-33.02, 9.96], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.55, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-10.34, 8.26], t(2068) = -0.22, p = 0.826; Std.
## beta = -0.11, 95% CI [-1.11, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-3.51, 4.29], t(2068) = 0.20, p = 0.845; Std.
## beta = 0.04, 95% CI [-0.38, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.42, 95% CI [-10.90, 2.07], t(2068) = -1.34, p = 0.182; Std.
## beta = -0.47, 95% CI [-1.17, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-5.08, 10.19], t(2068) = 0.66, p = 0.512; Std.
## beta = 0.27, 95% CI [-0.55, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-5.65, 3.75], t(2068) = -0.40, p = 0.693; Std.
## beta = -0.10, 95% CI [-0.61, 0.40])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.12, 95% CI [2.82, 19.41], t(2068) = 2.63, p = 0.009; Std.
## beta = 1.19, 95% CI [0.30, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.45, 8.64], t(2068) = 1.10, p = 0.273; Std.
## beta = 0.33, 95% CI [-0.26, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-7.89, 2.80], t(2068) = -0.93, p = 0.351; Std.
## beta = -0.27, 95% CI [-0.85, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.01, 0.33], t(2068) = -1.78, p = 0.075; Std.
## beta = -0.36, 95% CI [-0.75, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.78, 95% CI [-63.63, -29.93], t(2068) = -5.44, p < .001;
## Std. beta = -5.03, 95% CI [-6.84, -3.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-9.56, 8.25], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.03, 0.89])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.85, 11.79], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.10, 95% CI [-1.06, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-9.59, 11.56], t(2068) = 0.18, p = 0.855; Std.
## beta = 0.11, 95% CI [-1.03, 1.24])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## BC_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to BC_5yrPreCensor = 0, is at 59.24 (95% CI [50.50, 67.98],
## t(2068) = 13.30, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.12, 95% CI [-6.46, 0.22], t(2068) = -1.83, p = 0.067; Std. beta =
## -0.42, 95% CI [-0.55, -0.29])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 0.34, 95% CI [-9.34, 10.02], t(2068) = 0.07, p = 0.946; Std. beta =
## -0.02, 95% CI [-0.17, 0.13])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.76, 95% CI [-40.86, 25.35], t(2068) = -0.46, p = 0.646; Std. beta = -1.83,
## 95% CI [-4.63, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.79, 95% CI [-9.98, 37.56], t(2068) = 1.14, p = 0.255; Std. beta = 0.94,
## 95% CI [-0.48, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-19.87, 26.50], t(2068) = 0.28, p = 0.779; Std. beta = -0.29,
## 95% CI [-1.81, 1.23])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-30.32, 8.06], t(2068) = -1.14, p = 0.256; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.07, 95% CI [-3.40, 43.55], t(2068) = 1.68, p = 0.094; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.83, 95% CI [3.00, 22.65], t(2068) = 2.56, p = 0.011; Std. beta = 0.37, 95%
## CI [-0.22, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-1.64, 45.22], t(2068) = 1.82, p = 0.068; Std. beta = 0.70,
## 95% CI [-0.78, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.12, 10.77], t(2068) = 0.88, p = 0.381; Std. beta = 0.09, 95%
## CI [-0.37, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.23, 95% CI [-2.02, 24.48], t(2068) = 1.66, p = 0.097; Std. beta = 0.38,
## 95% CI [-0.42, 1.19])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.91], t(2068) = -0.23, p = 0.815; Std. beta = 0.08,
## 95% CI [-0.33, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-19.02, 8.41], t(2068) = -0.76, p = 0.448; Std. beta = 0.22,
## 95% CI [-0.72, 1.15])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-2.71, 12.16], t(2068) = 1.25, p = 0.213; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-12.38, 5.02], t(2068) = -0.83, p = 0.407; Std. beta = -0.07,
## 95% CI [-0.60, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-28.55, 19.07], t(2068) = -0.39, p = 0.696; Std. beta = 0.35,
## 95% CI [-1.25, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.54, 95% CI [-19.23, 20.31], t(2068) = 0.05, p = 0.957; Std. beta = 0.55,
## 95% CI [-0.64, 1.74])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.01, 95% CI [-20.58, 48.59], t(2068) = 0.79, p = 0.427; Std. beta = 0.83,
## 95% CI [-1.21, 2.87])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.22, 95% CI [-0.39, 28.83], t(2068) = 1.91, p = 0.056; Std. beta = 1.10,
## 95% CI [0.18, 2.01])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.81, 95% CI [-11.84, 35.46], t(2068) = 0.98, p = 0.328; Std. beta = 0.62,
## 95% CI [-0.87, 2.11])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.04, 95% CI [-1.47, 33.55], t(2068) = 1.80, p = 0.073; Std. beta = 0.76,
## 95% CI [-0.32, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-22.48, 36.61], t(2068) = 0.47, p = 0.639; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.56, 95% CI [-60.70, 5.58], t(2068) = -1.63, p = 0.103; Std. beta = -1.91,
## 95% CI [-4.30, 0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.95, 95% CI [-29.79, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.70,
## 95% CI [-1.63, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-27.24, 39.15], t(2068) = 0.35, p = 0.725; Std. beta = 0.35,
## 95% CI [-1.61, 2.31])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.62, 95% CI [-22.95, 24.19], t(2068) = 0.05, p = 0.959; Std. beta = 0.60,
## 95% CI [-1.52, 2.72])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-7.31, 24.61], t(2068) = 1.06, p = 0.288; Std. beta = 0.75, 95%
## CI [-0.33, 1.84])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-10.24, 17.84], t(2068) = 0.53, p = 0.596; Std. beta = 0.26,
## 95% CI [-0.65, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.14, 36.30], t(2068) = 0.25, p = 0.804; Std. beta = 0.63,
## 95% CI [-1.29, 2.55])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.33, 95% CI [-9.19, 11.85], t(2068) = 0.25, p = 0.804; Std. beta = -0.26,
## 95% CI [-0.96, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.48, 95% CI [-25.77, 4.80], t(2068) = -1.34, p = 0.179; Std. beta = -0.53,
## 95% CI [-1.69, 0.62])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-6.96, 19.37], t(2068) = 0.92, p = 0.356; Std. beta = 0.32, 95%
## CI [-0.49, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.83, 95% CI [-12.13, 15.78], t(2068) = 0.26, p = 0.797; Std. beta = -0.51,
## 95% CI [-1.38, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.48, 19.97], t(2068) = 0.08, p = 0.939; Std. beta = -0.98,
## 95% CI [-3.06, 1.09])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-36.59, 29.32], t(2068) = -0.22, p = 0.829; Std. beta = -0.31,
## 95% CI [-2.24, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-10.57, 19.06], t(2068) = 0.56, p = 0.574; Std. beta = 0.28,
## 95% CI [-0.60, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-4.79, 29.29], t(2068) = 1.41, p = 0.159; Std. beta = 0.33,
## 95% CI [-0.74, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.56, 95% CI [-32.37, 1.24], t(2068) = -1.82, p = 0.069; Std. beta = -0.69,
## 95% CI [-1.81, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-10.39, 15.53], t(2068) = 0.39, p = 0.697; Std. beta = 0.07,
## 95% CI [-0.73, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-13.49, 25.88], t(2068) = 0.62, p = 0.537; Std. beta = 1.36,
## 95% CI [0.12, 2.60])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.26, 2.42], t(2068) = -1.64, p = 0.101; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.95, 95% CI [-3.46, 29.37], t(2068) = 1.55, p = 0.122; Std. beta = 0.54,
## 95% CI [-0.46, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.59, 95% CI [1.28, 23.91], t(2068) = 2.18, p = 0.029; Std. beta = 0.45, 95%
## CI [-0.24, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.83, 95% CI [-14.32, 51.98], t(2068) = 1.11, p = 0.265; Std. beta = -3.06,
## 95% CI [-5.24, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.58, 95% CI [5.46, 51.70], t(2068) = 2.42, p = 0.015; Std. beta = 1.63, 95%
## CI [0.14, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-19.86, 18.30], t(2068) = -0.08, p = 0.936; Std. beta = 0.04,
## 95% CI [-1.28, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.63, 10.10], t(2068) = -0.05, p = 0.960; Std. beta = 0.07,
## 95% CI [-0.89, 1.04])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -1.19, 95% CI [-4.90, 2.53], t(2068) =
## -0.63, p = 0.531; Std. beta = -0.03, 95% CI [-0.13, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.38, 95% CI [-44.25, 13.49], t(2068) = -1.04, p = 0.296;
## Std. beta = -1.65, 95% CI [-4.75, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-8.44, 11.24], t(2068) = 0.28, p = 0.781; Std.
## beta = 0.15, 95% CI [-0.91, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.44, 95% CI [-16.28, 5.41], t(2068) = -0.98, p = 0.326; Std.
## beta = -0.58, 95% CI [-1.75, 0.58])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-13.35, 11.05], t(2068) = -0.18, p = 0.854;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.00, 95% CI [-12.37, 6.37], t(2068) = -0.63, p = 0.531; Std.
## beta = -0.32, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.31, 95% CI [-7.27, -1.35], t(2068) = -2.86, p = 0.004; Std.
## beta = -0.46, 95% CI [-0.78, -0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.62, 95% CI [-14.92, 1.68], t(2068) = -1.57, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.22, 95% CI [-3.76, 1.32], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.13, 95% CI [-0.40, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-7.54, 1.28], t(2068) = -1.39, p = 0.164; Std.
## beta = -0.34, 95% CI [-0.81, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.45, 95% CI [-0.90, 3.81], t(2068) = 1.21, p = 0.226; Std.
## beta = 0.16, 95% CI [-0.10, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-0.90, 12.85], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.64, 95% CI [-0.10, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.43, 1.72], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.09, 95% CI [-0.37, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-1.60, 4.95], t(2068) = 1.00, p = 0.316; Std.
## beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.07, 95% CI [-6.14, 20.29], t(2068) = 1.05, p = 0.294; Std.
## beta = 0.76, 95% CI [-0.66, 2.18])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.80, 95% CI [-0.59, 12.19], t(2068) = 1.78, p = 0.075; Std.
## beta = 0.62, 95% CI [-0.06, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-2.43, 8.21], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-9.03, 7.27], t(2068) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.97, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-10.06, 5.77], t(2068) = -0.53, p = 0.595; Std.
## beta = -0.23, 95% CI [-1.08, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-34.29, 39.91], t(2068) = 0.15, p = 0.882; Std.
## beta = 0.30, 95% CI [-3.68, 4.29])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-25.44, 19.11], t(2068) = -0.28, p = 0.780;
## Std. beta = -0.34, 95% CI [-2.73, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-3.12, 7.26], t(2068) = 0.78, p = 0.434; Std.
## beta = 0.22, 95% CI [-0.34, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.33, 95% CI [-14.79, 27.45], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.68, 95% CI [-1.59, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-5.69, 11.09], t(2068) = 0.63, p = 0.528; Std.
## beta = 0.29, 95% CI [-0.61, 1.19])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-5.95, 6.67], t(2068) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.64, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-4.42, 13.15], t(2068) = 0.97, p = 0.330; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.83, 95% CI [-9.11, 1.44], t(2068) = -1.43, p = 0.154; Std.
## beta = -0.41, 95% CI [-0.98, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-8.89, 10.85], t(2068) = 0.19, p = 0.846; Std.
## beta = 0.11, 95% CI [-0.96, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-5.30, 4.22], t(2068) = -0.22, p = 0.824; Std.
## beta = -0.06, 95% CI [-0.57, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.94, 95% CI [-12.44, -1.45], t(2068) = -2.48, p = 0.013;
## Std. beta = -0.75, 95% CI [-1.34, -0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.53, 95% CI [-33.02, 9.96], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.55, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-10.34, 8.26], t(2068) = -0.22, p = 0.826; Std.
## beta = -0.11, 95% CI [-1.11, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-3.51, 4.29], t(2068) = 0.20, p = 0.845; Std.
## beta = 0.04, 95% CI [-0.38, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.42, 95% CI [-10.90, 2.07], t(2068) = -1.34, p = 0.182; Std.
## beta = -0.47, 95% CI [-1.17, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-5.08, 10.19], t(2068) = 0.66, p = 0.512; Std.
## beta = 0.27, 95% CI [-0.55, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-5.65, 3.75], t(2068) = -0.40, p = 0.693; Std.
## beta = -0.10, 95% CI [-0.61, 0.40])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.12, 95% CI [2.82, 19.41], t(2068) = 2.63, p = 0.009; Std.
## beta = 1.19, 95% CI [0.30, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.45, 8.64], t(2068) = 1.10, p = 0.273; Std.
## beta = 0.33, 95% CI [-0.26, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-7.89, 2.80], t(2068) = -0.93, p = 0.351; Std.
## beta = -0.27, 95% CI [-0.85, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.01, 0.33], t(2068) = -1.78, p = 0.075; Std.
## beta = -0.36, 95% CI [-0.75, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.78, 95% CI [-63.63, -29.93], t(2068) = -5.44, p < .001;
## Std. beta = -5.03, 95% CI [-6.84, -3.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-9.56, 8.25], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.03, 0.89])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.85, 11.79], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.10, 95% CI [-1.06, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-9.59, 11.56], t(2068) = 0.18, p = 0.855; Std.
## beta = 0.11, 95% CI [-1.03, 1.24])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.21. The model's intercept, corresponding to site =
## Simmons, is at 59.24 (95% CI [50.50, 67.98], t(2068) = 13.30, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.12, 95% CI [-6.46, 0.22], t(2068) = -1.83, p = 0.067; Std. beta =
## -0.42, 95% CI [-0.55, -0.29])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 0.34, 95% CI [-9.34, 10.02], t(2068) = 0.07, p = 0.946; Std. beta =
## -0.02, 95% CI [-0.17, 0.13])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.76, 95% CI [-40.86, 25.35], t(2068) = -0.46, p = 0.646; Std. beta = -1.83,
## 95% CI [-4.63, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.79, 95% CI [-9.98, 37.56], t(2068) = 1.14, p = 0.255; Std. beta = 0.94,
## 95% CI [-0.48, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-19.87, 26.50], t(2068) = 0.28, p = 0.779; Std. beta = -0.29,
## 95% CI [-1.81, 1.23])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-30.32, 8.06], t(2068) = -1.14, p = 0.256; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.07, 95% CI [-3.40, 43.55], t(2068) = 1.68, p = 0.094; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.83, 95% CI [3.00, 22.65], t(2068) = 2.56, p = 0.011; Std. beta = 0.37, 95%
## CI [-0.22, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-1.64, 45.22], t(2068) = 1.82, p = 0.068; Std. beta = 0.70,
## 95% CI [-0.78, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.12, 10.77], t(2068) = 0.88, p = 0.381; Std. beta = 0.09, 95%
## CI [-0.37, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.23, 95% CI [-2.02, 24.48], t(2068) = 1.66, p = 0.097; Std. beta = 0.38,
## 95% CI [-0.42, 1.19])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.91], t(2068) = -0.23, p = 0.815; Std. beta = 0.08,
## 95% CI [-0.33, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-19.02, 8.41], t(2068) = -0.76, p = 0.448; Std. beta = 0.22,
## 95% CI [-0.72, 1.15])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-2.71, 12.16], t(2068) = 1.25, p = 0.213; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-12.38, 5.02], t(2068) = -0.83, p = 0.407; Std. beta = -0.07,
## 95% CI [-0.60, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-28.55, 19.07], t(2068) = -0.39, p = 0.696; Std. beta = 0.35,
## 95% CI [-1.25, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.54, 95% CI [-19.23, 20.31], t(2068) = 0.05, p = 0.957; Std. beta = 0.55,
## 95% CI [-0.64, 1.74])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.01, 95% CI [-20.58, 48.59], t(2068) = 0.79, p = 0.427; Std. beta = 0.83,
## 95% CI [-1.21, 2.87])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.22, 95% CI [-0.39, 28.83], t(2068) = 1.91, p = 0.056; Std. beta = 1.10,
## 95% CI [0.18, 2.01])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.81, 95% CI [-11.84, 35.46], t(2068) = 0.98, p = 0.328; Std. beta = 0.62,
## 95% CI [-0.87, 2.11])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.04, 95% CI [-1.47, 33.55], t(2068) = 1.80, p = 0.073; Std. beta = 0.76,
## 95% CI [-0.32, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-22.48, 36.61], t(2068) = 0.47, p = 0.639; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.56, 95% CI [-60.70, 5.58], t(2068) = -1.63, p = 0.103; Std. beta = -1.91,
## 95% CI [-4.30, 0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.95, 95% CI [-29.79, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.70,
## 95% CI [-1.63, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-27.24, 39.15], t(2068) = 0.35, p = 0.725; Std. beta = 0.35,
## 95% CI [-1.61, 2.31])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.62, 95% CI [-22.95, 24.19], t(2068) = 0.05, p = 0.959; Std. beta = 0.60,
## 95% CI [-1.52, 2.72])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-7.31, 24.61], t(2068) = 1.06, p = 0.288; Std. beta = 0.75, 95%
## CI [-0.33, 1.84])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-10.24, 17.84], t(2068) = 0.53, p = 0.596; Std. beta = 0.26,
## 95% CI [-0.65, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.14, 36.30], t(2068) = 0.25, p = 0.804; Std. beta = 0.63,
## 95% CI [-1.29, 2.55])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.33, 95% CI [-9.19, 11.85], t(2068) = 0.25, p = 0.804; Std. beta = -0.26,
## 95% CI [-0.96, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.48, 95% CI [-25.77, 4.80], t(2068) = -1.34, p = 0.179; Std. beta = -0.53,
## 95% CI [-1.69, 0.62])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-6.96, 19.37], t(2068) = 0.92, p = 0.356; Std. beta = 0.32, 95%
## CI [-0.49, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.83, 95% CI [-12.13, 15.78], t(2068) = 0.26, p = 0.797; Std. beta = -0.51,
## 95% CI [-1.38, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.48, 19.97], t(2068) = 0.08, p = 0.939; Std. beta = -0.98,
## 95% CI [-3.06, 1.09])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-36.59, 29.32], t(2068) = -0.22, p = 0.829; Std. beta = -0.31,
## 95% CI [-2.24, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-10.57, 19.06], t(2068) = 0.56, p = 0.574; Std. beta = 0.28,
## 95% CI [-0.60, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-4.79, 29.29], t(2068) = 1.41, p = 0.159; Std. beta = 0.33,
## 95% CI [-0.74, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.56, 95% CI [-32.37, 1.24], t(2068) = -1.82, p = 0.069; Std. beta = -0.69,
## 95% CI [-1.81, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-10.39, 15.53], t(2068) = 0.39, p = 0.697; Std. beta = 0.07,
## 95% CI [-0.73, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-13.49, 25.88], t(2068) = 0.62, p = 0.537; Std. beta = 1.36,
## 95% CI [0.12, 2.60])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.26, 2.42], t(2068) = -1.64, p = 0.101; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.95, 95% CI [-3.46, 29.37], t(2068) = 1.55, p = 0.122; Std. beta = 0.54,
## 95% CI [-0.46, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.59, 95% CI [1.28, 23.91], t(2068) = 2.18, p = 0.029; Std. beta = 0.45, 95%
## CI [-0.24, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.83, 95% CI [-14.32, 51.98], t(2068) = 1.11, p = 0.265; Std. beta = -3.06,
## 95% CI [-5.24, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.58, 95% CI [5.46, 51.70], t(2068) = 2.42, p = 0.015; Std. beta = 1.63, 95%
## CI [0.14, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-19.86, 18.30], t(2068) = -0.08, p = 0.936; Std. beta = 0.04,
## 95% CI [-1.28, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.63, 10.10], t(2068) = -0.05, p = 0.960; Std. beta = 0.07,
## 95% CI [-0.89, 1.04])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -1.19, 95% CI [-4.90, 2.53], t(2068) =
## -0.63, p = 0.531; Std. beta = -0.03, 95% CI [-0.13, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.38, 95% CI [-44.25, 13.49], t(2068) = -1.04, p = 0.296;
## Std. beta = -1.65, 95% CI [-4.75, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-8.44, 11.24], t(2068) = 0.28, p = 0.781; Std.
## beta = 0.15, 95% CI [-0.91, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.44, 95% CI [-16.28, 5.41], t(2068) = -0.98, p = 0.326; Std.
## beta = -0.58, 95% CI [-1.75, 0.58])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-13.35, 11.05], t(2068) = -0.18, p = 0.854;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.00, 95% CI [-12.37, 6.37], t(2068) = -0.63, p = 0.531; Std.
## beta = -0.32, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.31, 95% CI [-7.27, -1.35], t(2068) = -2.86, p = 0.004; Std.
## beta = -0.46, 95% CI [-0.78, -0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.62, 95% CI [-14.92, 1.68], t(2068) = -1.57, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.22, 95% CI [-3.76, 1.32], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.13, 95% CI [-0.40, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-7.54, 1.28], t(2068) = -1.39, p = 0.164; Std.
## beta = -0.34, 95% CI [-0.81, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.45, 95% CI [-0.90, 3.81], t(2068) = 1.21, p = 0.226; Std.
## beta = 0.16, 95% CI [-0.10, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-0.90, 12.85], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.64, 95% CI [-0.10, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.43, 1.72], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.09, 95% CI [-0.37, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-1.60, 4.95], t(2068) = 1.00, p = 0.316; Std.
## beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.07, 95% CI [-6.14, 20.29], t(2068) = 1.05, p = 0.294; Std.
## beta = 0.76, 95% CI [-0.66, 2.18])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.80, 95% CI [-0.59, 12.19], t(2068) = 1.78, p = 0.075; Std.
## beta = 0.62, 95% CI [-0.06, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-2.43, 8.21], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-9.03, 7.27], t(2068) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.97, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-10.06, 5.77], t(2068) = -0.53, p = 0.595; Std.
## beta = -0.23, 95% CI [-1.08, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-34.29, 39.91], t(2068) = 0.15, p = 0.882; Std.
## beta = 0.30, 95% CI [-3.68, 4.29])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-25.44, 19.11], t(2068) = -0.28, p = 0.780;
## Std. beta = -0.34, 95% CI [-2.73, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-3.12, 7.26], t(2068) = 0.78, p = 0.434; Std.
## beta = 0.22, 95% CI [-0.34, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.33, 95% CI [-14.79, 27.45], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.68, 95% CI [-1.59, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-5.69, 11.09], t(2068) = 0.63, p = 0.528; Std.
## beta = 0.29, 95% CI [-0.61, 1.19])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-5.95, 6.67], t(2068) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.64, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-4.42, 13.15], t(2068) = 0.97, p = 0.330; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.83, 95% CI [-9.11, 1.44], t(2068) = -1.43, p = 0.154; Std.
## beta = -0.41, 95% CI [-0.98, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-8.89, 10.85], t(2068) = 0.19, p = 0.846; Std.
## beta = 0.11, 95% CI [-0.96, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-5.30, 4.22], t(2068) = -0.22, p = 0.824; Std.
## beta = -0.06, 95% CI [-0.57, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.94, 95% CI [-12.44, -1.45], t(2068) = -2.48, p = 0.013;
## Std. beta = -0.75, 95% CI [-1.34, -0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.53, 95% CI [-33.02, 9.96], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.55, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-10.34, 8.26], t(2068) = -0.22, p = 0.826; Std.
## beta = -0.11, 95% CI [-1.11, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-3.51, 4.29], t(2068) = 0.20, p = 0.845; Std.
## beta = 0.04, 95% CI [-0.38, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.42, 95% CI [-10.90, 2.07], t(2068) = -1.34, p = 0.182; Std.
## beta = -0.47, 95% CI [-1.17, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-5.08, 10.19], t(2068) = 0.66, p = 0.512; Std.
## beta = 0.27, 95% CI [-0.55, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-5.65, 3.75], t(2068) = -0.40, p = 0.693; Std.
## beta = -0.10, 95% CI [-0.61, 0.40])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.12, 95% CI [2.82, 19.41], t(2068) = 2.63, p = 0.009; Std.
## beta = 1.19, 95% CI [0.30, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.45, 8.64], t(2068) = 1.10, p = 0.273; Std.
## beta = 0.33, 95% CI [-0.26, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-7.89, 2.80], t(2068) = -0.93, p = 0.351; Std.
## beta = -0.27, 95% CI [-0.85, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.01, 0.33], t(2068) = -1.78, p = 0.075; Std.
## beta = -0.36, 95% CI [-0.75, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.78, 95% CI [-63.63, -29.93], t(2068) = -5.44, p < .001;
## Std. beta = -5.03, 95% CI [-6.84, -3.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-9.56, 8.25], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.03, 0.89])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.85, 11.79], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.10, 95% CI [-1.06, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-9.59, 11.56], t(2068) = 0.18, p = 0.855; Std.
## beta = 0.11, 95% CI [-1.03, 1.24])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to cohort = CARE-PF, is at 59.24 (95% CI [50.50, 67.98], t(2068)
## = 13.30, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.12, 95% CI [-6.46, 0.22], t(2068) = -1.83, p = 0.067; Std. beta =
## -0.42, 95% CI [-0.55, -0.29])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 0.34, 95% CI [-9.34, 10.02], t(2068) = 0.07, p = 0.946; Std. beta =
## -0.02, 95% CI [-0.17, 0.13])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.76, 95% CI [-40.86, 25.35], t(2068) = -0.46, p = 0.646; Std. beta = -1.83,
## 95% CI [-4.63, 0.97])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.79, 95% CI [-9.98, 37.56], t(2068) = 1.14, p = 0.255; Std. beta = 0.94,
## 95% CI [-0.48, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-19.87, 26.50], t(2068) = 0.28, p = 0.779; Std. beta = -0.29,
## 95% CI [-1.81, 1.23])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-30.32, 8.06], t(2068) = -1.14, p = 0.256; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.07, 95% CI [-3.40, 43.55], t(2068) = 1.68, p = 0.094; Std. beta = 0.92,
## 95% CI [-0.58, 2.42])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.83, 95% CI [3.00, 22.65], t(2068) = 2.56, p = 0.011; Std. beta = 0.37, 95%
## CI [-0.22, 0.97])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.79, 95% CI [-1.64, 45.22], t(2068) = 1.82, p = 0.068; Std. beta = 0.70,
## 95% CI [-0.78, 2.17])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.33, 95% CI [-4.12, 10.77], t(2068) = 0.88, p = 0.381; Std. beta = 0.09, 95%
## CI [-0.37, 0.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.23, 95% CI [-2.02, 24.48], t(2068) = 1.66, p = 0.097; Std. beta = 0.38,
## 95% CI [-0.42, 1.19])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.91], t(2068) = -0.23, p = 0.815; Std. beta = 0.08,
## 95% CI [-0.33, 0.50])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-19.02, 8.41], t(2068) = -0.76, p = 0.448; Std. beta = 0.22,
## 95% CI [-0.72, 1.15])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.73, 95% CI [-2.71, 12.16], t(2068) = 1.25, p = 0.213; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-12.38, 5.02], t(2068) = -0.83, p = 0.407; Std. beta = -0.07,
## 95% CI [-0.60, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-28.55, 19.07], t(2068) = -0.39, p = 0.696; Std. beta = 0.35,
## 95% CI [-1.25, 1.96])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.54, 95% CI [-19.23, 20.31], t(2068) = 0.05, p = 0.957; Std. beta = 0.55,
## 95% CI [-0.64, 1.74])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.01, 95% CI [-20.58, 48.59], t(2068) = 0.79, p = 0.427; Std. beta = 0.83,
## 95% CI [-1.21, 2.87])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.22, 95% CI [-0.39, 28.83], t(2068) = 1.91, p = 0.056; Std. beta = 1.10,
## 95% CI [0.18, 2.01])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.81, 95% CI [-11.84, 35.46], t(2068) = 0.98, p = 0.328; Std. beta = 0.62,
## 95% CI [-0.87, 2.11])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.04, 95% CI [-1.47, 33.55], t(2068) = 1.80, p = 0.073; Std. beta = 0.76,
## 95% CI [-0.32, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.06, 95% CI [-22.48, 36.61], t(2068) = 0.47, p = 0.639; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.56, 95% CI [-60.70, 5.58], t(2068) = -1.63, p = 0.103; Std. beta = -1.91,
## 95% CI [-4.30, 0.48])
## - The effect of site [16R] is statistically significant and negative (beta =
## -14.95, 95% CI [-29.79, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.70,
## 95% CI [-1.63, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-27.24, 39.15], t(2068) = 0.35, p = 0.725; Std. beta = 0.35,
## 95% CI [-1.61, 2.31])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.62, 95% CI [-22.95, 24.19], t(2068) = 0.05, p = 0.959; Std. beta = 0.60,
## 95% CI [-1.52, 2.72])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-7.31, 24.61], t(2068) = 1.06, p = 0.288; Std. beta = 0.75, 95%
## CI [-0.33, 1.84])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.80, 95% CI [-10.24, 17.84], t(2068) = 0.53, p = 0.596; Std. beta = 0.26,
## 95% CI [-0.65, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.08, 95% CI [-28.14, 36.30], t(2068) = 0.25, p = 0.804; Std. beta = 0.63,
## 95% CI [-1.29, 2.55])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 1.33, 95% CI [-9.19, 11.85], t(2068) = 0.25, p = 0.804; Std. beta = -0.26,
## 95% CI [-0.96, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.48, 95% CI [-25.77, 4.80], t(2068) = -1.34, p = 0.179; Std. beta = -0.53,
## 95% CI [-1.69, 0.62])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-6.96, 19.37], t(2068) = 0.92, p = 0.356; Std. beta = 0.32, 95%
## CI [-0.49, 1.13])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.83, 95% CI [-12.13, 15.78], t(2068) = 0.26, p = 0.797; Std. beta = -0.51,
## 95% CI [-1.38, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.48, 19.97], t(2068) = 0.08, p = 0.939; Std. beta = -0.98,
## 95% CI [-3.06, 1.09])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-36.59, 29.32], t(2068) = -0.22, p = 0.829; Std. beta = -0.31,
## 95% CI [-2.24, 1.63])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-10.57, 19.06], t(2068) = 0.56, p = 0.574; Std. beta = 0.28,
## 95% CI [-0.60, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-4.79, 29.29], t(2068) = 1.41, p = 0.159; Std. beta = 0.33,
## 95% CI [-0.74, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.56, 95% CI [-32.37, 1.24], t(2068) = -1.82, p = 0.069; Std. beta = -0.69,
## 95% CI [-1.81, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-10.39, 15.53], t(2068) = 0.39, p = 0.697; Std. beta = 0.07,
## 95% CI [-0.73, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.20, 95% CI [-13.49, 25.88], t(2068) = 0.62, p = 0.537; Std. beta = 1.36,
## 95% CI [0.12, 2.60])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.42, 95% CI [-27.26, 2.42], t(2068) = -1.64, p = 0.101; Std. beta = -0.46,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.95, 95% CI [-3.46, 29.37], t(2068) = 1.55, p = 0.122; Std. beta = 0.54,
## 95% CI [-0.46, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.59, 95% CI [1.28, 23.91], t(2068) = 2.18, p = 0.029; Std. beta = 0.45, 95%
## CI [-0.24, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.83, 95% CI [-14.32, 51.98], t(2068) = 1.11, p = 0.265; Std. beta = -3.06,
## 95% CI [-5.24, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.58, 95% CI [5.46, 51.70], t(2068) = 2.42, p = 0.015; Std. beta = 1.63, 95%
## CI [0.14, 3.12])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-19.86, 18.30], t(2068) = -0.08, p = 0.936; Std. beta = 0.04,
## 95% CI [-1.28, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.63, 10.10], t(2068) = -0.05, p = 0.960; Std. beta = 0.07,
## 95% CI [-0.89, 1.04])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -1.19, 95% CI [-4.90, 2.53], t(2068) =
## -0.63, p = 0.531; Std. beta = -0.03, 95% CI [-0.13, 0.07])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.38, 95% CI [-44.25, 13.49], t(2068) = -1.04, p = 0.296;
## Std. beta = -1.65, 95% CI [-4.75, 1.45])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-8.44, 11.24], t(2068) = 0.28, p = 0.781; Std.
## beta = 0.15, 95% CI [-0.91, 1.21])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.44, 95% CI [-16.28, 5.41], t(2068) = -0.98, p = 0.326; Std.
## beta = -0.58, 95% CI [-1.75, 0.58])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-13.35, 11.05], t(2068) = -0.18, p = 0.854;
## Std. beta = -0.12, 95% CI [-1.43, 1.19])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.00, 95% CI [-12.37, 6.37], t(2068) = -0.63, p = 0.531; Std.
## beta = -0.32, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -4.31, 95% CI [-7.27, -1.35], t(2068) = -2.86, p = 0.004; Std.
## beta = -0.46, 95% CI [-0.78, -0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.62, 95% CI [-14.92, 1.68], t(2068) = -1.57, p = 0.118; Std.
## beta = -0.71, 95% CI [-1.60, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.22, 95% CI [-3.76, 1.32], t(2068) = -0.94, p = 0.345; Std.
## beta = -0.13, 95% CI [-0.40, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-7.54, 1.28], t(2068) = -1.39, p = 0.164; Std.
## beta = -0.34, 95% CI [-0.81, 0.14])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.45, 95% CI [-0.90, 3.81], t(2068) = 1.21, p = 0.226; Std.
## beta = 0.16, 95% CI [-0.10, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-0.90, 12.85], t(2068) = 1.71, p = 0.088; Std.
## beta = 0.64, 95% CI [-0.10, 1.38])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.43, 1.72], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.09, 95% CI [-0.37, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-1.60, 4.95], t(2068) = 1.00, p = 0.316; Std.
## beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.07, 95% CI [-6.14, 20.29], t(2068) = 1.05, p = 0.294; Std.
## beta = 0.76, 95% CI [-0.66, 2.18])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.80, 95% CI [-0.59, 12.19], t(2068) = 1.78, p = 0.075; Std.
## beta = 0.62, 95% CI [-0.06, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.89, 95% CI [-2.43, 8.21], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-9.03, 7.27], t(2068) = -0.21, p = 0.832; Std.
## beta = -0.09, 95% CI [-0.97, 0.78])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -2.14, 95% CI [-10.06, 5.77], t(2068) = -0.53, p = 0.595; Std.
## beta = -0.23, 95% CI [-1.08, 0.62])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-34.29, 39.91], t(2068) = 0.15, p = 0.882; Std.
## beta = 0.30, 95% CI [-3.68, 4.29])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-25.44, 19.11], t(2068) = -0.28, p = 0.780;
## Std. beta = -0.34, 95% CI [-2.73, 2.05])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-3.12, 7.26], t(2068) = 0.78, p = 0.434; Std.
## beta = 0.22, 95% CI [-0.34, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.33, 95% CI [-14.79, 27.45], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.68, 95% CI [-1.59, 2.95])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-5.69, 11.09], t(2068) = 0.63, p = 0.528; Std.
## beta = 0.29, 95% CI [-0.61, 1.19])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-5.95, 6.67], t(2068) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.64, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-4.42, 13.15], t(2068) = 0.97, p = 0.330; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.83, 95% CI [-9.11, 1.44], t(2068) = -1.43, p = 0.154; Std.
## beta = -0.41, 95% CI [-0.98, 0.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-8.89, 10.85], t(2068) = 0.19, p = 0.846; Std.
## beta = 0.11, 95% CI [-0.96, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-5.30, 4.22], t(2068) = -0.22, p = 0.824; Std.
## beta = -0.06, 95% CI [-0.57, 0.45])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.94, 95% CI [-12.44, -1.45], t(2068) = -2.48, p = 0.013;
## Std. beta = -0.75, 95% CI [-1.34, -0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.53, 95% CI [-33.02, 9.96], t(2068) = -1.05, p = 0.293;
## Std. beta = -1.24, 95% CI [-3.55, 1.07])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-10.34, 8.26], t(2068) = -0.22, p = 0.826; Std.
## beta = -0.11, 95% CI [-1.11, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-3.51, 4.29], t(2068) = 0.20, p = 0.845; Std.
## beta = 0.04, 95% CI [-0.38, 0.46])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.42, 95% CI [-10.90, 2.07], t(2068) = -1.34, p = 0.182; Std.
## beta = -0.47, 95% CI [-1.17, 0.22])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.55, 95% CI [-5.08, 10.19], t(2068) = 0.66, p = 0.512; Std.
## beta = 0.27, 95% CI [-0.55, 1.09])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-5.65, 3.75], t(2068) = -0.40, p = 0.693; Std.
## beta = -0.10, 95% CI [-0.61, 0.40])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.12, 95% CI [2.82, 19.41], t(2068) = 2.63, p = 0.009; Std.
## beta = 1.19, 95% CI [0.30, 2.08])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.10, 95% CI [-2.45, 8.64], t(2068) = 1.10, p = 0.273; Std.
## beta = 0.33, 95% CI [-0.26, 0.93])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-7.89, 2.80], t(2068) = -0.93, p = 0.351; Std.
## beta = -0.27, 95% CI [-0.85, 0.30])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-7.01, 0.33], t(2068) = -1.78, p = 0.075; Std.
## beta = -0.36, 95% CI [-0.75, 0.04])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.78, 95% CI [-63.63, -29.93], t(2068) = -5.44, p < .001;
## Std. beta = -5.03, 95% CI [-6.84, -3.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.65, 95% CI [-9.56, 8.25], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.03, 0.89])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-9.85, 11.79], t(2068) = 0.18, p = 0.860; Std.
## beta = 0.10, 95% CI [-1.06, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-9.59, 11.56], t(2068) = 0.18, p = 0.855; Std.
## beta = 0.11, 95% CI [-1.03, 1.24])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*BC_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14368.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2978 -0.4356 -0.0133 0.4443 4.5109
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 233.62 15.285
## time_firstPFT 13.58 3.685 -0.08
## Residual 25.62 5.061
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 30.91695 7.04263 4.390
## time_firstPFT -0.54285 2.67455 -0.203
## BC_5yrPreCensor 1.57369 4.80274 0.328
## disadv 3.99865 2.88510 1.386
## dich_RaceNon-White -7.47347 2.81512 -2.655
## sexF 3.72974 1.75103 2.130
## age_dx 0.38353 0.09142 4.195
## smokeHxFormer 3.63547 1.73203 2.099
## smokeHxAlways 18.71972 8.45427 2.214
## smokeHxUnknown -2.53418 3.93455 -0.644
## site02R -10.96084 16.23647 -0.675
## site03R 12.12510 11.75710 1.031
## site04R 3.18401 11.32417 0.281
## site05R -12.33844 9.42050 -1.310
## site06R 10.43676 16.17325 0.645
## site07R 11.99116 4.83775 2.479
## site09R 20.81650 11.48817 1.812
## site101 4.79976 3.69241 1.300
## site102 13.00962 6.53475 1.991
## site103 -0.79832 3.41748 -0.234
## site104 -6.33045 6.78462 -0.933
## site105 5.02156 3.67553 1.366
## site106 -5.19590 4.34439 -1.196
## site107 -1.60138 11.66340 -0.137
## site108 6.03387 10.15498 0.594
## site10R 11.81753 17.24812 0.685
## site11R 10.64624 7.16325 1.486
## site12R 7.87383 11.57249 0.680
## site13R 17.62740 8.63557 2.041
## site14R 6.26597 14.70544 0.426
## site15R -33.86439 16.26147 -2.082
## site16R -8.77685 7.36494 -1.192
## site17R 10.38493 16.37700 0.634
## site18R -3.02292 11.57278 -0.261
## site19R 8.83091 7.88642 1.120
## site20R 2.69176 6.88936 0.391
## site21R 2.59071 15.70196 0.165
## site22R -2.38428 5.25184 -0.454
## site23R -12.85778 8.97225 -1.433
## site24R 5.38648 6.44368 0.836
## site25R 1.13209 6.92459 0.163
## site28R 4.16384 9.46625 0.440
## site29R -5.80087 16.14947 -0.359
## site31R 5.73473 7.32213 0.783
## site32R 10.03006 8.40928 1.193
## site33R -13.64986 8.25870 -1.653
## site34R 0.43451 6.35274 0.068
## site35R 0.22549 9.68805 0.023
## site36R -11.28389 7.29113 -1.548
## site37R 15.69625 8.12947 1.931
## site38R 12.63138 5.54421 2.278
## site39R 24.67529 16.52726 1.493
## site40R 25.58466 11.32058 2.260
## site41R -2.90153 9.41404 -0.308
## site42R -0.76402 5.14895 -0.148
## time_firstPFT:BC_5yrPreCensor -0.97010 1.98981 -0.488
## time_firstPFT:disadv 0.05661 1.10638 0.051
## time_firstPFT:dich_RaceNon-White 0.19015 1.12586 0.169
## time_firstPFT:sexF 0.06103 0.66602 0.092
## time_firstPFT:age_dx -0.05931 0.03473 -1.708
## time_firstPFT:smokeHxFormer 0.54144 0.67404 0.803
## time_firstPFT:smokeHxAlways 1.20316 5.31541 0.226
## time_firstPFT:smokeHxUnknown 1.63162 1.68507 0.968
## time_firstPFT:site02R -14.49476 14.76920 -0.981
## time_firstPFT:site03R 2.79886 5.10274 0.549
## time_firstPFT:site04R -4.92291 5.61426 -0.877
## time_firstPFT:site05R -0.76465 6.26973 -0.122
## time_firstPFT:site07R -3.66893 1.56834 -2.339
## time_firstPFT:site09R -6.33953 4.32634 -1.465
## time_firstPFT:site101 -0.94070 1.34147 -0.701
## time_firstPFT:site102 -3.06549 2.30549 -1.330
## time_firstPFT:site103 1.73820 1.29639 1.341
## time_firstPFT:site104 6.49885 3.61530 1.798
## time_firstPFT:site105 -0.67577 1.34970 -0.501
## time_firstPFT:site106 2.40449 1.74411 1.379
## time_firstPFT:site107 7.35226 6.77925 1.085
## time_firstPFT:site108 5.84847 3.56241 1.642
## time_firstPFT:site11R 3.84666 2.80438 1.372
## time_firstPFT:site12R -0.32448 4.25523 -0.076
## time_firstPFT:site13R -1.47710 4.11407 -0.359
## time_firstPFT:site14R 3.36139 18.95601 0.177
## time_firstPFT:site15R -2.89811 11.41050 -0.254
## time_firstPFT:site16R 1.89401 2.74556 0.690
## time_firstPFT:site18R 6.89835 10.81550 0.638
## time_firstPFT:site19R 4.17836 4.39255 0.951
## time_firstPFT:site20R 1.30344 3.30076 0.395
## time_firstPFT:site21R 4.57409 4.56147 1.003
## time_firstPFT:site22R -2.78487 2.76519 -1.007
## time_firstPFT:site23R 9.14246 24.71696 0.370
## time_firstPFT:site24R -0.32337 2.46515 -0.131
## time_firstPFT:site25R -6.04633 2.90039 -2.085
## time_firstPFT:site28R -10.03139 11.08247 -0.905
## time_firstPFT:site29R -0.24203 4.85173 -0.050
## time_firstPFT:site31R 0.61184 2.07787 0.294
## time_firstPFT:site32R -3.65600 3.39962 -1.075
## time_firstPFT:site33R 3.25994 4.01622 0.812
## time_firstPFT:site34R -0.66321 2.47380 -0.268
## time_firstPFT:site35R 12.16606 4.32926 2.810
## time_firstPFT:site36R 3.50092 2.89142 1.211
## time_firstPFT:site37R -1.74702 2.86427 -0.610
## time_firstPFT:site38R -3.01628 1.91781 -1.573
## time_firstPFT:site39R -47.26644 8.75201 -5.401
## time_firstPFT:site40R 0.61175 4.68342 0.131
## time_firstPFT:site41R 1.82972 5.57578 0.328
## time_firstPFT:site42R 2.02327 5.41389 0.374##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.694report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## BC_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 30.92 (95% CI [17.11, 44.73], t(2038)
## = 4.39, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## BC_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to
## BC_5yrPreCensor = 0, is at 30.92 (95% CI [17.11, 44.73], t(2038) = 4.39, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 30.92 (95% CI [17.11,
## 44.73], t(2038) = 4.39, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to dich_Race =
## White, is at 30.92 (95% CI [17.11, 44.73], t(2038) = 4.39, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 30.92 (95% CI [17.11,
## 44.73], t(2038) = 4.39, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 30.92 (95% CI [17.11,
## 44.73], t(2038) = 4.39, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 30.92 (95% CI
## [17.11, 44.73], t(2038) = 4.39, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 30.92 (95% CI [17.11,
## 44.73], t(2038) = 4.39, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to cohort =
## CARE-PF, is at 30.92 (95% CI [17.11, 44.73], t(2038) = 4.39, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -0.54, 95% CI [-5.79, 4.70], t(2038) = -0.20, p = 0.839; Std. beta =
## -0.50, 95% CI [-0.68, -0.32])
## - The effect of BC 5yrPreCensor is statistically non-significant and positive
## (beta = 1.57, 95% CI [-7.85, 10.99], t(2038) = 0.33, p = 0.743; Std. beta =
## 1.45e-03, 95% CI [-0.15, 0.15])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.66, 9.66], t(2038) = 1.39, p = 0.166; Std. beta = 0.07, 95% CI
## [-0.03, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.47, 95% CI [-12.99, -1.95], t(2038) = -2.65, p = 0.008; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.30, 7.16], t(2038) = 2.13, p = 0.033; Std. beta = 0.23, 95% CI
## [7.49e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.20, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.24, 7.03], t(2038) = 2.10, p = 0.036; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.72, 95% CI [2.14, 35.30], t(2038) = 2.21, p = 0.027; Std. beta =
## 1.21, 95% CI [-9.93e-04, 2.42])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -3.41e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -10.96, 95% CI [-42.80, 20.88], t(2038) = -0.68, p = 0.500; Std. beta =
## -1.94, 95% CI [-4.73, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 12.13, 95% CI [-10.93, 35.18], t(2038) = 1.03, p = 0.303; Std. beta = 0.97,
## 95% CI [-0.44, 2.37])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.18, 95% CI [-19.02, 25.39], t(2038) = 0.28, p = 0.779; Std. beta = -0.25,
## 95% CI [-1.75, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.81, 6.14], t(2038) = -1.31, p = 0.190; Std. beta = -0.80,
## 95% CI [-2.17, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-21.28, 42.15], t(2038) = 0.65, p = 0.519; Std. beta = 0.62,
## 95% CI [-1.26, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.99, 95% CI [2.50, 21.48], t(2038) = 2.48, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.21, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.82, 95% CI [-1.71, 43.35], t(2038) = 1.81, p = 0.070; Std. beta = 0.66,
## 95% CI [-0.78, 2.11])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.80, 95% CI [-2.44, 12.04], t(2038) = 1.30, p = 0.194; Std. beta = 0.20, 95%
## CI [-0.26, 0.66])
## - The effect of site [102] is statistically significant and positive (beta =
## 13.01, 95% CI [0.19, 25.83], t(2038) = 1.99, p = 0.047; Std. beta = 0.49, 95%
## CI [-0.30, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-7.50, 5.90], t(2038) = -0.23, p = 0.815; Std. beta = 0.11,
## 95% CI [-0.32, 0.54])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.33, 95% CI [-19.64, 6.98], t(2038) = -0.93, p = 0.351; Std. beta = 0.21,
## 95% CI [-0.73, 1.14])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.02, 95% CI [-2.19, 12.23], t(2038) = 1.37, p = 0.172; Std. beta = 0.24, 95%
## CI [-0.22, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-13.72, 3.32], t(2038) = -1.20, p = 0.232; Std. beta = -0.09,
## 95% CI [-0.63, 0.44])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.60, 95% CI [-24.47, 21.27], t(2038) = -0.14, p = 0.891; Std. beta = 0.56,
## 95% CI [-1.02, 2.14])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.03, 95% CI [-13.88, 25.95], t(2038) = 0.59, p = 0.552; Std. beta = 0.88,
## 95% CI [-0.35, 2.11])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.82, 95% CI [-22.01, 45.64], t(2038) = 0.69, p = 0.493; Std. beta = 0.70,
## 95% CI [-1.30, 2.69])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.65, 95% CI [-3.40, 24.69], t(2038) = 1.49, p = 0.137; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.87, 95% CI [-14.82, 30.57], t(2038) = 0.68, p = 0.496; Std. beta = 0.44,
## 95% CI [-1.03, 1.90])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.63, 95% CI [0.69, 34.56], t(2038) = 2.04, p = 0.041; Std. beta = 0.91, 95%
## CI [-0.15, 1.97])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.27, 95% CI [-22.57, 35.11], t(2038) = 0.43, p = 0.670; Std. beta = 0.67,
## 95% CI [-1.95, 3.29])
## - The effect of site [15R] is statistically significant and negative (beta =
## -33.86, 95% CI [-65.76, -1.97], t(2038) = -2.08, p = 0.037; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-23.22, 5.67], t(2038) = -1.19, p = 0.234; Std. beta = -0.35,
## 95% CI [-1.28, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.38, 95% CI [-21.73, 42.50], t(2038) = 0.63, p = 0.526; Std. beta = 0.61,
## 95% CI [-1.28, 2.51])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.02, 95% CI [-25.72, 19.67], t(2038) = -0.26, p = 0.794; Std. beta = 0.44,
## 95% CI [-1.67, 2.55])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.83, 95% CI [-6.64, 24.30], t(2038) = 1.12, p = 0.263; Std. beta = 0.89, 95%
## CI [-0.19, 1.98])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.69, 95% CI [-10.82, 16.20], t(2038) = 0.39, p = 0.696; Std. beta = 0.28,
## 95% CI [-0.62, 1.17])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-28.20, 33.38], t(2038) = 0.16, p = 0.869; Std. beta = 0.56,
## 95% CI [-1.30, 2.42])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.38, 95% CI [-12.68, 7.92], t(2038) = -0.45, p = 0.650; Std. beta = -0.39,
## 95% CI [-1.09, 0.31])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.86, 95% CI [-30.45, 4.74], t(2038) = -1.43, p = 0.152; Std. beta = 0.06,
## 95% CI [-4.00, 4.12])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.39, 95% CI [-7.25, 18.02], t(2038) = 0.84, p = 0.403; Std. beta = 0.29, 95%
## CI [-0.50, 1.08])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.13, 95% CI [-12.45, 14.71], t(2038) = 0.16, p = 0.870; Std. beta = -0.47,
## 95% CI [-1.34, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-14.40, 22.73], t(2038) = 0.44, p = 0.660; Std. beta = -0.65,
## 95% CI [-2.74, 1.43])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.80, 95% CI [-37.47, 25.87], t(2038) = -0.36, p = 0.719; Std. beta = -0.36,
## 95% CI [-2.25, 1.53])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.73, 95% CI [-8.62, 20.09], t(2038) = 0.78, p = 0.434; Std. beta = 0.39, 95%
## CI [-0.48, 1.26])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.03, 95% CI [-6.46, 26.52], t(2038) = 1.19, p = 0.233; Std. beta = 0.26,
## 95% CI [-0.79, 1.32])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.65, 95% CI [-29.85, 2.55], t(2038) = -1.65, p = 0.099; Std. beta = -0.51,
## 95% CI [-1.62, 0.60])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-12.02, 12.89], t(2038) = 0.07, p = 0.945; Std. beta = -0.03,
## 95% CI [-0.82, 0.75])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-18.77, 19.22], t(2038) = 0.02, p = 0.981; Std. beta = 1.10,
## 95% CI [-0.12, 2.33])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.28, 95% CI [-25.58, 3.01], t(2038) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.28, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.70, 95% CI [-0.25, 31.64], t(2038) = 1.93, p = 0.054; Std. beta = 0.77,
## 95% CI [-0.22, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.63, 95% CI [1.76, 23.50], t(2038) = 2.28, p = 0.023; Std. beta = 0.48, 95%
## CI [-0.20, 1.15])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 24.68, 95% CI [-7.74, 57.09], t(2038) = 1.49, p = 0.136; Std. beta = -2.78,
## 95% CI [-4.96, -0.60])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.58, 95% CI [3.38, 47.79], t(2038) = 2.26, p = 0.024; Std. beta = 1.56, 95%
## CI [0.09, 3.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.90, 95% CI [-21.36, 15.56], t(2038) = -0.31, p = 0.758; Std. beta =
## -7.34e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-10.86, 9.33], t(2038) = -0.15, p = 0.882; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and negative (beta = -0.97, 95% CI [-4.87, 2.93], t(2038) =
## -0.49, p = 0.626; Std. beta = -0.03, 95% CI [-0.13, 0.08])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.06, 95% CI [-2.11, 2.23], t(2038) = 0.05, p = 0.959; Std.
## beta = 1.73e-03, 95% CI [-0.06, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.19, 95% CI [-2.02, 2.40], t(2038) =
## 0.17, p = 0.866; Std. beta = 0.02, 95% CI [-0.22, 0.26])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.06, 95% CI [-1.25, 1.37], t(2038) = 0.09, p = 0.927; Std.
## beta = 6.57e-03, 95% CI [-0.13, 0.15])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 8.80e-03], t(2038) = -1.71, p = 0.088;
## Std. beta = -0.06, 95% CI [-0.13, 8.73e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.54, 95% CI [-0.78, 1.86], t(2038) =
## 0.80, p = 0.422; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.20, 95% CI [-9.22, 11.63], t(2038) =
## 0.23, p = 0.821; Std. beta = 0.13, 95% CI [-0.99, 1.25])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.63, 95% CI [-1.67, 4.94], t(2038) =
## 0.97, p = 0.333; Std. beta = 0.18, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.49, 95% CI [-43.46, 14.47], t(2038) = -0.98, p = 0.327;
## Std. beta = -1.56, 95% CI [-4.68, 1.56])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.80, 95% CI [-7.21, 12.81], t(2038) = 0.55, p = 0.583; Std.
## beta = 0.30, 95% CI [-0.78, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.92, 95% CI [-15.93, 6.09], t(2038) = -0.88, p = 0.381; Std.
## beta = -0.53, 95% CI [-1.72, 0.66])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-13.06, 11.53], t(2038) = -0.12, p = 0.903;
## Std. beta = -0.08, 95% CI [-1.41, 1.24])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.67, 95% CI [-6.74, -0.59], t(2038) = -2.34, p = 0.019; Std.
## beta = -0.40, 95% CI [-0.73, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.34, 95% CI [-14.82, 2.14], t(2038) = -1.47, p = 0.143; Std.
## beta = -0.68, 95% CI [-1.60, 0.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-3.57, 1.69], t(2038) = -0.70, p = 0.483; Std.
## beta = -0.10, 95% CI [-0.38, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-7.59, 1.46], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.33, 95% CI [-0.82, 0.16])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.74, 95% CI [-0.80, 4.28], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.19, 95% CI [-0.09, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-0.59, 13.59], t(2038) = 1.80, p = 0.072; Std.
## beta = 0.70, 95% CI [-0.06, 1.46])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-3.32, 1.97], t(2038) = -0.50, p = 0.617; Std.
## beta = -0.07, 95% CI [-0.36, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-1.02, 5.82], t(2038) = 1.38, p = 0.168; Std.
## beta = 0.26, 95% CI [-0.11, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.35, 95% CI [-5.94, 20.65], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.79, 95% CI [-0.64, 2.22])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.85, 95% CI [-1.14, 12.83], t(2038) = 1.64, p = 0.101; Std.
## beta = 0.63, 95% CI [-0.12, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.85, 95% CI [-1.65, 9.35], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.41, 95% CI [-0.18, 1.01])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-8.67, 8.02], t(2038) = -0.08, p = 0.939; Std.
## beta = -0.03, 95% CI [-0.93, 0.86])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-9.55, 6.59], t(2038) = -0.36, p = 0.720; Std.
## beta = -0.16, 95% CI [-1.03, 0.71])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-33.81, 40.54], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.90, 95% CI [-25.28, 19.48], t(2038) = -0.25, p = 0.800;
## Std. beta = -0.31, 95% CI [-2.72, 2.10])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.89, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.90, 95% CI [-14.31, 28.11], t(2038) = 0.64, p = 0.524; Std.
## beta = 0.74, 95% CI [-1.54, 3.03])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.18, 95% CI [-4.44, 12.79], t(2038) = 0.95, p = 0.342; Std.
## beta = 0.45, 95% CI [-0.48, 1.38])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-5.17, 7.78], t(2038) = 0.39, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.56, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.57, 95% CI [-4.37, 13.52], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.78, 95% CI [-8.21, 2.64], t(2038) = -1.01, p = 0.314; Std.
## beta = -0.30, 95% CI [-0.88, 0.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.14, 95% CI [-39.33, 57.62], t(2038) = 0.37, p = 0.712; Std.
## beta = 0.98, 95% CI [-4.24, 6.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.32, 95% CI [-5.16, 4.51], t(2038) = -0.13, p = 0.896; Std.
## beta = -0.03, 95% CI [-0.56, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.05, 95% CI [-11.73, -0.36], t(2038) = -2.08, p = 0.037;
## Std. beta = -0.65, 95% CI [-1.26, -0.04])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.03, 95% CI [-31.77, 11.70], t(2038) = -0.91, p = 0.365;
## Std. beta = -1.08, 95% CI [-3.42, 1.26])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.24, 95% CI [-9.76, 9.27], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.05, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-3.46, 4.69], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.07, 95% CI [-0.37, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.66, 95% CI [-10.32, 3.01], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.39, 95% CI [-1.11, 0.32])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-4.62, 11.14], t(2038) = 0.81, p = 0.417; Std.
## beta = 0.35, 95% CI [-0.50, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.66, 95% CI [-5.51, 4.19], t(2038) = -0.27, p = 0.789; Std.
## beta = -0.07, 95% CI [-0.59, 0.45])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.17, 95% CI [3.68, 20.66], t(2038) = 2.81, p = 0.005; Std.
## beta = 1.31, 95% CI [0.40, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-2.17, 9.17], t(2038) = 1.21, p = 0.226; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.36, 3.87], t(2038) = -0.61, p = 0.542; Std.
## beta = -0.19, 95% CI [-0.79, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.78, 0.74], t(2038) = -1.57, p = 0.116; Std.
## beta = -0.32, 95% CI [-0.73, 0.08])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -47.27, 95% CI [-64.43, -30.10], t(2038) = -5.40, p < .001;
## Std. beta = -5.09, 95% CI [-6.94, -3.24])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.61, 95% CI [-8.57, 9.80], t(2038) = 0.13, p = 0.896; Std.
## beta = 0.07, 95% CI [-0.92, 1.06])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-9.11, 12.76], t(2038) = 0.33, p = 0.743; Std.
## beta = 0.20, 95% CI [-0.98, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.02, 95% CI [-8.59, 12.64], t(2038) = 0.37, p = 0.709; Std.
## beta = 0.22, 95% CI [-0.93, 1.36])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*OM_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14567.7
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3249 -0.4409 -0.0157 0.4482 4.5313
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 257.32 16.041
## time_firstPFT 13.00 3.606 -0.11
## Residual 25.58 5.057
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 60.64937 3.35393 18.083
## time_firstPFT -3.98879 1.22319 -3.261
## OM_5yrPreCensor -0.33558 0.92688 -0.362
## site02R -7.78631 16.84086 -0.462
## site03R 13.61553 12.08133 1.127
## site04R 3.01459 11.78371 0.256
## site05R -11.36639 9.73463 -1.168
## site06R 20.61200 12.05087 1.710
## site07R 12.48450 4.78020 2.612
## site09R 21.41544 11.86463 1.805
## site101 2.88966 3.33547 0.866
## site102 10.85361 6.37511 1.702
## site103 -1.04406 2.74701 -0.380
## site104 -5.79093 6.51542 -0.889
## site105 4.48969 3.17313 1.415
## site106 -3.91217 4.19840 -0.932
## site107 -5.18985 11.95276 -0.434
## site108 -0.12434 9.67028 -0.013
## site10R 14.27735 17.47217 0.817
## site11R 14.44123 7.46612 1.934
## site12R 11.15949 11.88075 0.939
## site13R 15.82614 8.87658 1.783
## site14R 6.63354 15.02259 0.442
## site15R -27.53788 16.86945 -1.632
## site16R -15.22788 7.52101 -2.025
## site17R 5.76715 16.87187 0.342
## site18R 0.50010 11.95162 0.042
## site19R 7.80137 7.82394 0.997
## site20R 3.43105 6.98357 0.491
## site21R 4.37227 16.44129 0.266
## site22R 0.99066 5.32047 0.186
## site23R -10.78366 7.63718 -1.412
## site24R 5.68941 6.47005 0.879
## site25R 1.65617 6.94935 0.238
## site28R 0.75037 9.79254 0.077
## site29R -4.18379 16.74591 -0.250
## site31R 4.00668 7.45754 0.537
## site32R 11.71823 8.47831 1.382
## site33R -15.97722 8.41908 -1.898
## site34R 2.15552 6.43974 0.335
## site35R 5.59565 9.82696 0.569
## site36R -12.51236 7.53174 -1.661
## site37R 12.80761 8.33347 1.537
## site38R 12.47641 5.64924 2.209
## site39R 18.16552 16.74052 1.085
## site40R 28.70360 11.78852 2.435
## site41R -0.98151 9.70676 -0.101
## site42R -0.50492 5.22870 -0.097
## time_firstPFT:OM_5yrPreCensor -0.04996 0.34358 -0.145
## time_firstPFT:site02R -15.10751 14.71667 -1.027
## time_firstPFT:site03R 1.59932 5.01030 0.319
## time_firstPFT:site04R -5.13063 5.51034 -0.931
## time_firstPFT:site05R -0.88589 6.20818 -0.143
## time_firstPFT:site06R -2.96832 4.81879 -0.616
## time_firstPFT:site07R -3.94797 1.38822 -2.844
## time_firstPFT:site09R -6.39087 4.21895 -1.515
## time_firstPFT:site101 -0.78798 1.08804 -0.724
## time_firstPFT:site102 -2.61024 2.08453 -1.252
## time_firstPFT:site103 1.91514 0.94375 2.029
## time_firstPFT:site104 6.43103 3.44295 1.868
## time_firstPFT:site105 -0.36623 1.05187 -0.348
## time_firstPFT:site106 2.02999 1.57233 1.291
## time_firstPFT:site107 7.57925 6.68929 1.133
## time_firstPFT:site108 6.48102 3.06877 2.112
## time_firstPFT:site11R 3.06119 2.72654 1.123
## time_firstPFT:site12R -0.38244 4.08326 -0.094
## time_firstPFT:site13R -1.90478 4.01749 -0.474
## time_firstPFT:site14R 3.07741 18.91459 0.163
## time_firstPFT:site15R -2.92948 11.35342 -0.258
## time_firstPFT:site16R 2.31794 2.62215 0.884
## time_firstPFT:site18R 6.60797 10.76570 0.614
## time_firstPFT:site19R 3.22158 4.20556 0.766
## time_firstPFT:site20R 0.76965 3.15322 0.244
## time_firstPFT:site21R 4.44228 4.49345 0.989
## time_firstPFT:site22R -3.58170 2.66534 -1.344
## time_firstPFT:site23R 1.38288 4.99520 0.277
## time_firstPFT:site24R -0.08977 2.32240 -0.039
## time_firstPFT:site25R -6.49655 2.70283 -2.404
## time_firstPFT:site28R -11.38672 10.95833 -1.039
## time_firstPFT:site29R -0.67297 4.71352 -0.143
## time_firstPFT:site31R 0.68136 1.93297 0.352
## time_firstPFT:site32R -4.06291 3.26192 -1.246
## time_firstPFT:site33R 2.99005 3.83788 0.779
## time_firstPFT:site34R -0.60562 2.33175 -0.260
## time_firstPFT:site35R 11.65852 4.14144 2.815
## time_firstPFT:site36R 3.27570 2.81564 1.163
## time_firstPFT:site37R -2.39727 2.71760 -0.882
## time_firstPFT:site38R -3.06838 1.82408 -1.682
## time_firstPFT:site39R -46.20589 8.54607 -5.407
## time_firstPFT:site40R -0.12775 4.46579 -0.029
## time_firstPFT:site41R 1.13344 5.51478 0.206
## time_firstPFT:site42R 1.19751 5.38249 0.222##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.924
## Unadjusted ICC: 0.729report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## OM_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.21. The model's
## intercept, corresponding to time_firstPFT = 0, is at 60.65 (95% CI [54.07,
## 67.23], t(2068) = 18.08, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.99, 95% CI [-6.39, -1.59], t(2068) = -3.26, p = 0.001; Std. beta = -0.44,
## 95% CI [-0.54, -0.34])
## - The effect of OM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.34, 95% CI [-2.15, 1.48], t(2068) = -0.36, p = 0.717; Std. beta =
## -0.02, 95% CI [-0.13, 0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-40.81, 25.24], t(2068) = -0.46, p = 0.644; Std. beta = -1.81,
## 95% CI [-4.61, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.08, 37.31], t(2068) = 1.13, p = 0.260; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.01, 95% CI [-20.09, 26.12], t(2068) = 0.26, p = 0.798; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-30.46, 7.72], t(2068) = -1.17, p = 0.243; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-3.02, 44.25], t(2068) = 1.71, p = 0.087; Std. beta = 0.95,
## 95% CI [-0.56, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.48, 95% CI [3.11, 21.86], t(2068) = 2.61, p = 0.009; Std. beta = 0.38, 95%
## CI [-0.18, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.42, 95% CI [-1.85, 44.68], t(2068) = 1.80, p = 0.071; Std. beta = 0.69,
## 95% CI [-0.77, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-3.65, 9.43], t(2068) = 0.87, p = 0.386; Std. beta = 0.10, 95%
## CI [-0.30, 0.50])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.85, 95% CI [-1.65, 23.36], t(2068) = 1.70, p = 0.089; Std. beta = 0.41,
## 95% CI [-0.35, 1.17])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.43, 4.34], t(2068) = -0.38, p = 0.704; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.57, 6.99], t(2068) = -0.89, p = 0.374; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.73, 10.71], t(2068) = 1.41, p = 0.157; Std. beta = 0.23, 95%
## CI [-0.15, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.91, 95% CI [-12.15, 4.32], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.19, 95% CI [-28.63, 18.25], t(2068) = -0.43, p = 0.664; Std. beta = 0.37,
## 95% CI [-1.22, 1.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.09, 18.84], t(2068) = -0.01, p = 0.990; Std. beta = 0.57,
## 95% CI [-0.57, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.28, 95% CI [-19.99, 48.54], t(2068) = 0.82, p = 0.414; Std. beta = 0.84,
## 95% CI [-1.18, 2.86])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.44, 95% CI [-0.20, 29.08], t(2068) = 1.93, p = 0.053; Std. beta = 1.12,
## 95% CI [0.21, 2.04])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.16, 95% CI [-12.14, 34.46], t(2068) = 0.94, p = 0.348; Std. beta = 0.62,
## 95% CI [-0.84, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-1.58, 33.23], t(2068) = 1.78, p = 0.075; Std. beta = 0.76,
## 95% CI [-0.30, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.63, 95% CI [-22.83, 36.09], t(2068) = 0.44, p = 0.659; Std. beta = 0.67,
## 95% CI [-1.95, 3.28])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.54, 95% CI [-60.62, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.27, 0.50])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.23, 95% CI [-29.98, -0.48], t(2068) = -2.02, p = 0.043; Std. beta = -0.69,
## 95% CI [-1.62, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-27.32, 38.85], t(2068) = 0.34, p = 0.733; Std. beta = 0.34,
## 95% CI [-1.61, 2.29])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.94, 23.94], t(2068) = 0.04, p = 0.967; Std. beta = 0.62,
## 95% CI [-1.50, 2.74])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-7.54, 23.14], t(2068) = 1.00, p = 0.319; Std. beta = 0.75, 95%
## CI [-0.30, 1.80])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-10.26, 17.13], t(2068) = 0.49, p = 0.623; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.37, 95% CI [-27.87, 36.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.65,
## 95% CI [-1.27, 2.57])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.99, 95% CI [-9.44, 11.42], t(2068) = 0.19, p = 0.852; Std. beta = -0.26,
## 95% CI [-0.95, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.76, 4.19], t(2068) = -1.41, p = 0.158; Std. beta = -0.51,
## 95% CI [-1.65, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-7.00, 18.38], t(2068) = 0.88, p = 0.379; Std. beta = 0.33, 95%
## CI [-0.45, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.66, 95% CI [-11.97, 15.28], t(2068) = 0.24, p = 0.812; Std. beta = -0.48,
## 95% CI [-1.33, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.45, 19.95], t(2068) = 0.08, p = 0.939; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.18, 95% CI [-37.02, 28.66], t(2068) = -0.25, p = 0.803; Std. beta = -0.31,
## 95% CI [-2.24, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-10.62, 18.63], t(2068) = 0.54, p = 0.591; Std. beta = 0.30,
## 95% CI [-0.57, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.72, 95% CI [-4.91, 28.35], t(2068) = 1.38, p = 0.167; Std. beta = 0.33,
## 95% CI [-0.71, 1.37])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.98, 95% CI [-32.49, 0.53], t(2068) = -1.90, p = 0.058; Std. beta = -0.68,
## 95% CI [-1.78, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-10.47, 14.78], t(2068) = 0.33, p = 0.738; Std. beta = 0.07,
## 95% CI [-0.71, 0.85])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-13.68, 24.87], t(2068) = 0.57, p = 0.569; Std. beta = 1.37,
## 95% CI [0.16, 2.58])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.28, 2.26], t(2068) = -1.66, p = 0.097; Std. beta = -0.45,
## 95% CI [-1.38, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.81, 95% CI [-3.54, 29.15], t(2068) = 1.54, p = 0.124; Std. beta = 0.54,
## 95% CI [-0.45, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.40, 23.56], t(2068) = 2.21, p = 0.027; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.17, 95% CI [-14.66, 51.00], t(2068) = 1.09, p = 0.278; Std. beta = -3.05,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.70, 95% CI [5.59, 51.82], t(2068) = 2.43, p = 0.015; Std. beta = 1.68, 95%
## CI [0.20, 3.17])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.98, 95% CI [-20.02, 18.05], t(2068) = -0.10, p = 0.919; Std. beta = 0.04,
## 95% CI [-1.27, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.50, 95% CI [-10.76, 9.75], t(2068) = -0.10, p = 0.923; Std. beta = 0.08,
## 95% CI [-0.88, 1.04])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.05, 95% CI [-0.72, 0.62], t(2068) =
## -0.15, p = 0.884; Std. beta = -4.90e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.11, 95% CI [-43.97, 13.75], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.23, 11.43], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.13, 95% CI [-15.94, 5.68], t(2068) = -0.93, p = 0.352; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.06, 11.29], t(2068) = -0.14, p = 0.887;
## Std. beta = -0.10, 95% CI [-1.40, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-12.42, 6.48], t(2068) = -0.62, p = 0.538; Std.
## beta = -0.32, 95% CI [-1.33, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.95, 95% CI [-6.67, -1.23], t(2068) = -2.84, p = 0.005; Std.
## beta = -0.42, 95% CI [-0.72, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.39, 95% CI [-14.66, 1.88], t(2068) = -1.51, p = 0.130; Std.
## beta = -0.69, 95% CI [-1.58, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.79, 95% CI [-2.92, 1.35], t(2068) = -0.72, p = 0.469; Std.
## beta = -0.08, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-6.70, 1.48], t(2068) = -1.25, p = 0.211; Std.
## beta = -0.28, 95% CI [-0.72, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.92, 95% CI [0.06, 3.77], t(2068) = 2.03, p = 0.043; Std.
## beta = 0.21, 95% CI [6.91e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-0.32, 13.18], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.69, 95% CI [-0.03, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.43, 1.70], t(2068) = -0.35, p = 0.728; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.05, 5.11], t(2068) = 1.29, p = 0.197; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.54, 20.70], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.60, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.48, 95% CI [0.46, 12.50], t(2068) = 2.11, p = 0.035; Std.
## beta = 0.70, 95% CI [0.05, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-2.29, 8.41], t(2068) = 1.12, p = 0.262; Std.
## beta = 0.33, 95% CI [-0.25, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-8.39, 7.63], t(2068) = -0.09, p = 0.925; Std.
## beta = -0.04, 95% CI [-0.90, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-9.78, 5.97], t(2068) = -0.47, p = 0.635; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.02, 40.17], t(2068) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.19, 19.34], t(2068) = -0.26, p = 0.796;
## Std. beta = -0.31, 95% CI [-2.71, 2.08])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-2.82, 7.46], t(2068) = 0.88, p = 0.377; Std.
## beta = 0.25, 95% CI [-0.30, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.61, 95% CI [-14.50, 27.72], t(2068) = 0.61, p = 0.539; Std.
## beta = 0.71, 95% CI [-1.56, 2.98])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.22, 95% CI [-5.03, 11.47], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.35, 95% CI [-0.54, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.41, 6.95], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.37, 13.25], t(2068) = 0.99, p = 0.323; Std.
## beta = 0.48, 95% CI [-0.47, 1.42])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.58, 95% CI [-8.81, 1.65], t(2068) = -1.34, p = 0.179; Std.
## beta = -0.38, 95% CI [-0.95, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-8.41, 11.18], t(2068) = 0.28, p = 0.782; Std.
## beta = 0.15, 95% CI [-0.90, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-4.64, 4.46], t(2068) = -0.04, p = 0.969; Std.
## beta = -9.65e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.50, 95% CI [-11.80, -1.20], t(2068) = -2.40, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.39, 95% CI [-32.88, 10.10], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.22, 95% CI [-3.53, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-9.92, 8.57], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.07, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.68, 95% CI [-3.11, 4.47], t(2068) = 0.35, p = 0.725; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-10.46, 2.33], t(2068) = -1.25, p = 0.213; Std.
## beta = -0.44, 95% CI [-1.12, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.54, 10.52], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.32, 95% CI [-0.49, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.18, 3.97], t(2068) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.56, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.66, 95% CI [3.54, 19.78], t(2068) = 2.82, p = 0.005; Std.
## beta = 1.25, 95% CI [0.38, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.25, 8.80], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-7.73, 2.93], t(2068) = -0.88, p = 0.378; Std.
## beta = -0.26, 95% CI [-0.83, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-6.65, 0.51], t(2068) = -1.68, p = 0.093; Std.
## beta = -0.33, 95% CI [-0.71, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.21, 95% CI [-62.97, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.89, 8.63], t(2068) = -0.03, p = 0.977; Std.
## beta = -0.01, 95% CI [-0.95, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-9.68, 11.95], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.12, 95% CI [-1.04, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.36, 11.75], t(2068) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## OM_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to OM_5yrPreCensor = 0, is at 60.65 (95% CI [54.07, 67.23],
## t(2068) = 18.08, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.99, 95% CI [-6.39, -1.59], t(2068) = -3.26, p = 0.001; Std. beta = -0.44,
## 95% CI [-0.54, -0.34])
## - The effect of OM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.34, 95% CI [-2.15, 1.48], t(2068) = -0.36, p = 0.717; Std. beta =
## -0.02, 95% CI [-0.13, 0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-40.81, 25.24], t(2068) = -0.46, p = 0.644; Std. beta = -1.81,
## 95% CI [-4.61, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.08, 37.31], t(2068) = 1.13, p = 0.260; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.01, 95% CI [-20.09, 26.12], t(2068) = 0.26, p = 0.798; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-30.46, 7.72], t(2068) = -1.17, p = 0.243; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-3.02, 44.25], t(2068) = 1.71, p = 0.087; Std. beta = 0.95,
## 95% CI [-0.56, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.48, 95% CI [3.11, 21.86], t(2068) = 2.61, p = 0.009; Std. beta = 0.38, 95%
## CI [-0.18, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.42, 95% CI [-1.85, 44.68], t(2068) = 1.80, p = 0.071; Std. beta = 0.69,
## 95% CI [-0.77, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-3.65, 9.43], t(2068) = 0.87, p = 0.386; Std. beta = 0.10, 95%
## CI [-0.30, 0.50])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.85, 95% CI [-1.65, 23.36], t(2068) = 1.70, p = 0.089; Std. beta = 0.41,
## 95% CI [-0.35, 1.17])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.43, 4.34], t(2068) = -0.38, p = 0.704; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.57, 6.99], t(2068) = -0.89, p = 0.374; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.73, 10.71], t(2068) = 1.41, p = 0.157; Std. beta = 0.23, 95%
## CI [-0.15, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.91, 95% CI [-12.15, 4.32], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.19, 95% CI [-28.63, 18.25], t(2068) = -0.43, p = 0.664; Std. beta = 0.37,
## 95% CI [-1.22, 1.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.09, 18.84], t(2068) = -0.01, p = 0.990; Std. beta = 0.57,
## 95% CI [-0.57, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.28, 95% CI [-19.99, 48.54], t(2068) = 0.82, p = 0.414; Std. beta = 0.84,
## 95% CI [-1.18, 2.86])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.44, 95% CI [-0.20, 29.08], t(2068) = 1.93, p = 0.053; Std. beta = 1.12,
## 95% CI [0.21, 2.04])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.16, 95% CI [-12.14, 34.46], t(2068) = 0.94, p = 0.348; Std. beta = 0.62,
## 95% CI [-0.84, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-1.58, 33.23], t(2068) = 1.78, p = 0.075; Std. beta = 0.76,
## 95% CI [-0.30, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.63, 95% CI [-22.83, 36.09], t(2068) = 0.44, p = 0.659; Std. beta = 0.67,
## 95% CI [-1.95, 3.28])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.54, 95% CI [-60.62, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.27, 0.50])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.23, 95% CI [-29.98, -0.48], t(2068) = -2.02, p = 0.043; Std. beta = -0.69,
## 95% CI [-1.62, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-27.32, 38.85], t(2068) = 0.34, p = 0.733; Std. beta = 0.34,
## 95% CI [-1.61, 2.29])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.94, 23.94], t(2068) = 0.04, p = 0.967; Std. beta = 0.62,
## 95% CI [-1.50, 2.74])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-7.54, 23.14], t(2068) = 1.00, p = 0.319; Std. beta = 0.75, 95%
## CI [-0.30, 1.80])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-10.26, 17.13], t(2068) = 0.49, p = 0.623; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.37, 95% CI [-27.87, 36.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.65,
## 95% CI [-1.27, 2.57])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.99, 95% CI [-9.44, 11.42], t(2068) = 0.19, p = 0.852; Std. beta = -0.26,
## 95% CI [-0.95, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.76, 4.19], t(2068) = -1.41, p = 0.158; Std. beta = -0.51,
## 95% CI [-1.65, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-7.00, 18.38], t(2068) = 0.88, p = 0.379; Std. beta = 0.33, 95%
## CI [-0.45, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.66, 95% CI [-11.97, 15.28], t(2068) = 0.24, p = 0.812; Std. beta = -0.48,
## 95% CI [-1.33, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.45, 19.95], t(2068) = 0.08, p = 0.939; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.18, 95% CI [-37.02, 28.66], t(2068) = -0.25, p = 0.803; Std. beta = -0.31,
## 95% CI [-2.24, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-10.62, 18.63], t(2068) = 0.54, p = 0.591; Std. beta = 0.30,
## 95% CI [-0.57, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.72, 95% CI [-4.91, 28.35], t(2068) = 1.38, p = 0.167; Std. beta = 0.33,
## 95% CI [-0.71, 1.37])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.98, 95% CI [-32.49, 0.53], t(2068) = -1.90, p = 0.058; Std. beta = -0.68,
## 95% CI [-1.78, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-10.47, 14.78], t(2068) = 0.33, p = 0.738; Std. beta = 0.07,
## 95% CI [-0.71, 0.85])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-13.68, 24.87], t(2068) = 0.57, p = 0.569; Std. beta = 1.37,
## 95% CI [0.16, 2.58])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.28, 2.26], t(2068) = -1.66, p = 0.097; Std. beta = -0.45,
## 95% CI [-1.38, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.81, 95% CI [-3.54, 29.15], t(2068) = 1.54, p = 0.124; Std. beta = 0.54,
## 95% CI [-0.45, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.40, 23.56], t(2068) = 2.21, p = 0.027; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.17, 95% CI [-14.66, 51.00], t(2068) = 1.09, p = 0.278; Std. beta = -3.05,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.70, 95% CI [5.59, 51.82], t(2068) = 2.43, p = 0.015; Std. beta = 1.68, 95%
## CI [0.20, 3.17])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.98, 95% CI [-20.02, 18.05], t(2068) = -0.10, p = 0.919; Std. beta = 0.04,
## 95% CI [-1.27, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.50, 95% CI [-10.76, 9.75], t(2068) = -0.10, p = 0.923; Std. beta = 0.08,
## 95% CI [-0.88, 1.04])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.05, 95% CI [-0.72, 0.62], t(2068) =
## -0.15, p = 0.884; Std. beta = -4.90e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.11, 95% CI [-43.97, 13.75], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.23, 11.43], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.13, 95% CI [-15.94, 5.68], t(2068) = -0.93, p = 0.352; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.06, 11.29], t(2068) = -0.14, p = 0.887;
## Std. beta = -0.10, 95% CI [-1.40, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-12.42, 6.48], t(2068) = -0.62, p = 0.538; Std.
## beta = -0.32, 95% CI [-1.33, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.95, 95% CI [-6.67, -1.23], t(2068) = -2.84, p = 0.005; Std.
## beta = -0.42, 95% CI [-0.72, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.39, 95% CI [-14.66, 1.88], t(2068) = -1.51, p = 0.130; Std.
## beta = -0.69, 95% CI [-1.58, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.79, 95% CI [-2.92, 1.35], t(2068) = -0.72, p = 0.469; Std.
## beta = -0.08, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-6.70, 1.48], t(2068) = -1.25, p = 0.211; Std.
## beta = -0.28, 95% CI [-0.72, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.92, 95% CI [0.06, 3.77], t(2068) = 2.03, p = 0.043; Std.
## beta = 0.21, 95% CI [6.91e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-0.32, 13.18], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.69, 95% CI [-0.03, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.43, 1.70], t(2068) = -0.35, p = 0.728; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.05, 5.11], t(2068) = 1.29, p = 0.197; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.54, 20.70], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.60, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.48, 95% CI [0.46, 12.50], t(2068) = 2.11, p = 0.035; Std.
## beta = 0.70, 95% CI [0.05, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-2.29, 8.41], t(2068) = 1.12, p = 0.262; Std.
## beta = 0.33, 95% CI [-0.25, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-8.39, 7.63], t(2068) = -0.09, p = 0.925; Std.
## beta = -0.04, 95% CI [-0.90, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-9.78, 5.97], t(2068) = -0.47, p = 0.635; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.02, 40.17], t(2068) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.19, 19.34], t(2068) = -0.26, p = 0.796;
## Std. beta = -0.31, 95% CI [-2.71, 2.08])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-2.82, 7.46], t(2068) = 0.88, p = 0.377; Std.
## beta = 0.25, 95% CI [-0.30, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.61, 95% CI [-14.50, 27.72], t(2068) = 0.61, p = 0.539; Std.
## beta = 0.71, 95% CI [-1.56, 2.98])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.22, 95% CI [-5.03, 11.47], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.35, 95% CI [-0.54, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.41, 6.95], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.37, 13.25], t(2068) = 0.99, p = 0.323; Std.
## beta = 0.48, 95% CI [-0.47, 1.42])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.58, 95% CI [-8.81, 1.65], t(2068) = -1.34, p = 0.179; Std.
## beta = -0.38, 95% CI [-0.95, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-8.41, 11.18], t(2068) = 0.28, p = 0.782; Std.
## beta = 0.15, 95% CI [-0.90, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-4.64, 4.46], t(2068) = -0.04, p = 0.969; Std.
## beta = -9.65e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.50, 95% CI [-11.80, -1.20], t(2068) = -2.40, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.39, 95% CI [-32.88, 10.10], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.22, 95% CI [-3.53, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-9.92, 8.57], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.07, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.68, 95% CI [-3.11, 4.47], t(2068) = 0.35, p = 0.725; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-10.46, 2.33], t(2068) = -1.25, p = 0.213; Std.
## beta = -0.44, 95% CI [-1.12, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.54, 10.52], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.32, 95% CI [-0.49, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.18, 3.97], t(2068) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.56, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.66, 95% CI [3.54, 19.78], t(2068) = 2.82, p = 0.005; Std.
## beta = 1.25, 95% CI [0.38, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.25, 8.80], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-7.73, 2.93], t(2068) = -0.88, p = 0.378; Std.
## beta = -0.26, 95% CI [-0.83, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-6.65, 0.51], t(2068) = -1.68, p = 0.093; Std.
## beta = -0.33, 95% CI [-0.71, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.21, 95% CI [-62.97, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.89, 8.63], t(2068) = -0.03, p = 0.977; Std.
## beta = -0.01, 95% CI [-0.95, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-9.68, 11.95], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.12, 95% CI [-1.04, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.36, 11.75], t(2068) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.21. The model's intercept, corresponding to site =
## Simmons, is at 60.65 (95% CI [54.07, 67.23], t(2068) = 18.08, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.99, 95% CI [-6.39, -1.59], t(2068) = -3.26, p = 0.001; Std. beta = -0.44,
## 95% CI [-0.54, -0.34])
## - The effect of OM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.34, 95% CI [-2.15, 1.48], t(2068) = -0.36, p = 0.717; Std. beta =
## -0.02, 95% CI [-0.13, 0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-40.81, 25.24], t(2068) = -0.46, p = 0.644; Std. beta = -1.81,
## 95% CI [-4.61, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.08, 37.31], t(2068) = 1.13, p = 0.260; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.01, 95% CI [-20.09, 26.12], t(2068) = 0.26, p = 0.798; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-30.46, 7.72], t(2068) = -1.17, p = 0.243; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-3.02, 44.25], t(2068) = 1.71, p = 0.087; Std. beta = 0.95,
## 95% CI [-0.56, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.48, 95% CI [3.11, 21.86], t(2068) = 2.61, p = 0.009; Std. beta = 0.38, 95%
## CI [-0.18, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.42, 95% CI [-1.85, 44.68], t(2068) = 1.80, p = 0.071; Std. beta = 0.69,
## 95% CI [-0.77, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-3.65, 9.43], t(2068) = 0.87, p = 0.386; Std. beta = 0.10, 95%
## CI [-0.30, 0.50])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.85, 95% CI [-1.65, 23.36], t(2068) = 1.70, p = 0.089; Std. beta = 0.41,
## 95% CI [-0.35, 1.17])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.43, 4.34], t(2068) = -0.38, p = 0.704; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.57, 6.99], t(2068) = -0.89, p = 0.374; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.73, 10.71], t(2068) = 1.41, p = 0.157; Std. beta = 0.23, 95%
## CI [-0.15, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.91, 95% CI [-12.15, 4.32], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.19, 95% CI [-28.63, 18.25], t(2068) = -0.43, p = 0.664; Std. beta = 0.37,
## 95% CI [-1.22, 1.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.09, 18.84], t(2068) = -0.01, p = 0.990; Std. beta = 0.57,
## 95% CI [-0.57, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.28, 95% CI [-19.99, 48.54], t(2068) = 0.82, p = 0.414; Std. beta = 0.84,
## 95% CI [-1.18, 2.86])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.44, 95% CI [-0.20, 29.08], t(2068) = 1.93, p = 0.053; Std. beta = 1.12,
## 95% CI [0.21, 2.04])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.16, 95% CI [-12.14, 34.46], t(2068) = 0.94, p = 0.348; Std. beta = 0.62,
## 95% CI [-0.84, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-1.58, 33.23], t(2068) = 1.78, p = 0.075; Std. beta = 0.76,
## 95% CI [-0.30, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.63, 95% CI [-22.83, 36.09], t(2068) = 0.44, p = 0.659; Std. beta = 0.67,
## 95% CI [-1.95, 3.28])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.54, 95% CI [-60.62, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.27, 0.50])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.23, 95% CI [-29.98, -0.48], t(2068) = -2.02, p = 0.043; Std. beta = -0.69,
## 95% CI [-1.62, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-27.32, 38.85], t(2068) = 0.34, p = 0.733; Std. beta = 0.34,
## 95% CI [-1.61, 2.29])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.94, 23.94], t(2068) = 0.04, p = 0.967; Std. beta = 0.62,
## 95% CI [-1.50, 2.74])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-7.54, 23.14], t(2068) = 1.00, p = 0.319; Std. beta = 0.75, 95%
## CI [-0.30, 1.80])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-10.26, 17.13], t(2068) = 0.49, p = 0.623; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.37, 95% CI [-27.87, 36.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.65,
## 95% CI [-1.27, 2.57])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.99, 95% CI [-9.44, 11.42], t(2068) = 0.19, p = 0.852; Std. beta = -0.26,
## 95% CI [-0.95, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.76, 4.19], t(2068) = -1.41, p = 0.158; Std. beta = -0.51,
## 95% CI [-1.65, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-7.00, 18.38], t(2068) = 0.88, p = 0.379; Std. beta = 0.33, 95%
## CI [-0.45, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.66, 95% CI [-11.97, 15.28], t(2068) = 0.24, p = 0.812; Std. beta = -0.48,
## 95% CI [-1.33, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.45, 19.95], t(2068) = 0.08, p = 0.939; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.18, 95% CI [-37.02, 28.66], t(2068) = -0.25, p = 0.803; Std. beta = -0.31,
## 95% CI [-2.24, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-10.62, 18.63], t(2068) = 0.54, p = 0.591; Std. beta = 0.30,
## 95% CI [-0.57, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.72, 95% CI [-4.91, 28.35], t(2068) = 1.38, p = 0.167; Std. beta = 0.33,
## 95% CI [-0.71, 1.37])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.98, 95% CI [-32.49, 0.53], t(2068) = -1.90, p = 0.058; Std. beta = -0.68,
## 95% CI [-1.78, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-10.47, 14.78], t(2068) = 0.33, p = 0.738; Std. beta = 0.07,
## 95% CI [-0.71, 0.85])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-13.68, 24.87], t(2068) = 0.57, p = 0.569; Std. beta = 1.37,
## 95% CI [0.16, 2.58])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.28, 2.26], t(2068) = -1.66, p = 0.097; Std. beta = -0.45,
## 95% CI [-1.38, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.81, 95% CI [-3.54, 29.15], t(2068) = 1.54, p = 0.124; Std. beta = 0.54,
## 95% CI [-0.45, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.40, 23.56], t(2068) = 2.21, p = 0.027; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.17, 95% CI [-14.66, 51.00], t(2068) = 1.09, p = 0.278; Std. beta = -3.05,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.70, 95% CI [5.59, 51.82], t(2068) = 2.43, p = 0.015; Std. beta = 1.68, 95%
## CI [0.20, 3.17])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.98, 95% CI [-20.02, 18.05], t(2068) = -0.10, p = 0.919; Std. beta = 0.04,
## 95% CI [-1.27, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.50, 95% CI [-10.76, 9.75], t(2068) = -0.10, p = 0.923; Std. beta = 0.08,
## 95% CI [-0.88, 1.04])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.05, 95% CI [-0.72, 0.62], t(2068) =
## -0.15, p = 0.884; Std. beta = -4.90e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.11, 95% CI [-43.97, 13.75], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.23, 11.43], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.13, 95% CI [-15.94, 5.68], t(2068) = -0.93, p = 0.352; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.06, 11.29], t(2068) = -0.14, p = 0.887;
## Std. beta = -0.10, 95% CI [-1.40, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-12.42, 6.48], t(2068) = -0.62, p = 0.538; Std.
## beta = -0.32, 95% CI [-1.33, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.95, 95% CI [-6.67, -1.23], t(2068) = -2.84, p = 0.005; Std.
## beta = -0.42, 95% CI [-0.72, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.39, 95% CI [-14.66, 1.88], t(2068) = -1.51, p = 0.130; Std.
## beta = -0.69, 95% CI [-1.58, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.79, 95% CI [-2.92, 1.35], t(2068) = -0.72, p = 0.469; Std.
## beta = -0.08, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-6.70, 1.48], t(2068) = -1.25, p = 0.211; Std.
## beta = -0.28, 95% CI [-0.72, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.92, 95% CI [0.06, 3.77], t(2068) = 2.03, p = 0.043; Std.
## beta = 0.21, 95% CI [6.91e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-0.32, 13.18], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.69, 95% CI [-0.03, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.43, 1.70], t(2068) = -0.35, p = 0.728; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.05, 5.11], t(2068) = 1.29, p = 0.197; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.54, 20.70], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.60, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.48, 95% CI [0.46, 12.50], t(2068) = 2.11, p = 0.035; Std.
## beta = 0.70, 95% CI [0.05, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-2.29, 8.41], t(2068) = 1.12, p = 0.262; Std.
## beta = 0.33, 95% CI [-0.25, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-8.39, 7.63], t(2068) = -0.09, p = 0.925; Std.
## beta = -0.04, 95% CI [-0.90, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-9.78, 5.97], t(2068) = -0.47, p = 0.635; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.02, 40.17], t(2068) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.19, 19.34], t(2068) = -0.26, p = 0.796;
## Std. beta = -0.31, 95% CI [-2.71, 2.08])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-2.82, 7.46], t(2068) = 0.88, p = 0.377; Std.
## beta = 0.25, 95% CI [-0.30, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.61, 95% CI [-14.50, 27.72], t(2068) = 0.61, p = 0.539; Std.
## beta = 0.71, 95% CI [-1.56, 2.98])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.22, 95% CI [-5.03, 11.47], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.35, 95% CI [-0.54, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.41, 6.95], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.37, 13.25], t(2068) = 0.99, p = 0.323; Std.
## beta = 0.48, 95% CI [-0.47, 1.42])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.58, 95% CI [-8.81, 1.65], t(2068) = -1.34, p = 0.179; Std.
## beta = -0.38, 95% CI [-0.95, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-8.41, 11.18], t(2068) = 0.28, p = 0.782; Std.
## beta = 0.15, 95% CI [-0.90, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-4.64, 4.46], t(2068) = -0.04, p = 0.969; Std.
## beta = -9.65e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.50, 95% CI [-11.80, -1.20], t(2068) = -2.40, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.39, 95% CI [-32.88, 10.10], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.22, 95% CI [-3.53, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-9.92, 8.57], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.07, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.68, 95% CI [-3.11, 4.47], t(2068) = 0.35, p = 0.725; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-10.46, 2.33], t(2068) = -1.25, p = 0.213; Std.
## beta = -0.44, 95% CI [-1.12, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.54, 10.52], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.32, 95% CI [-0.49, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.18, 3.97], t(2068) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.56, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.66, 95% CI [3.54, 19.78], t(2068) = 2.82, p = 0.005; Std.
## beta = 1.25, 95% CI [0.38, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.25, 8.80], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-7.73, 2.93], t(2068) = -0.88, p = 0.378; Std.
## beta = -0.26, 95% CI [-0.83, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-6.65, 0.51], t(2068) = -1.68, p = 0.093; Std.
## beta = -0.33, 95% CI [-0.71, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.21, 95% CI [-62.97, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.89, 8.63], t(2068) = -0.03, p = 0.977; Std.
## beta = -0.01, 95% CI [-0.95, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-9.68, 11.95], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.12, 95% CI [-1.04, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.36, 11.75], t(2068) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to cohort = CARE-PF, is at 60.65 (95% CI [54.07, 67.23], t(2068)
## = 18.08, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -3.99, 95% CI [-6.39, -1.59], t(2068) = -3.26, p = 0.001; Std. beta = -0.44,
## 95% CI [-0.54, -0.34])
## - The effect of OM 5yrPreCensor is statistically non-significant and negative
## (beta = -0.34, 95% CI [-2.15, 1.48], t(2068) = -0.36, p = 0.717; Std. beta =
## -0.02, 95% CI [-0.13, 0.08])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-40.81, 25.24], t(2068) = -0.46, p = 0.644; Std. beta = -1.81,
## 95% CI [-4.61, 0.99])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.08, 37.31], t(2068) = 1.13, p = 0.260; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.01, 95% CI [-20.09, 26.12], t(2068) = 0.26, p = 0.798; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-30.46, 7.72], t(2068) = -1.17, p = 0.243; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 20.61, 95% CI [-3.02, 44.25], t(2068) = 1.71, p = 0.087; Std. beta = 0.95,
## 95% CI [-0.56, 2.46])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.48, 95% CI [3.11, 21.86], t(2068) = 2.61, p = 0.009; Std. beta = 0.38, 95%
## CI [-0.18, 0.95])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.42, 95% CI [-1.85, 44.68], t(2068) = 1.80, p = 0.071; Std. beta = 0.69,
## 95% CI [-0.77, 2.16])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-3.65, 9.43], t(2068) = 0.87, p = 0.386; Std. beta = 0.10, 95%
## CI [-0.30, 0.50])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.85, 95% CI [-1.65, 23.36], t(2068) = 1.70, p = 0.089; Std. beta = 0.41,
## 95% CI [-0.35, 1.17])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.43, 4.34], t(2068) = -0.38, p = 0.704; Std. beta = 0.11,
## 95% CI [-0.22, 0.44])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-18.57, 6.99], t(2068) = -0.89, p = 0.374; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.73, 10.71], t(2068) = 1.41, p = 0.157; Std. beta = 0.23, 95%
## CI [-0.15, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.91, 95% CI [-12.15, 4.32], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -5.19, 95% CI [-28.63, 18.25], t(2068) = -0.43, p = 0.664; Std. beta = 0.37,
## 95% CI [-1.22, 1.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-19.09, 18.84], t(2068) = -0.01, p = 0.990; Std. beta = 0.57,
## 95% CI [-0.57, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.28, 95% CI [-19.99, 48.54], t(2068) = 0.82, p = 0.414; Std. beta = 0.84,
## 95% CI [-1.18, 2.86])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.44, 95% CI [-0.20, 29.08], t(2068) = 1.93, p = 0.053; Std. beta = 1.12,
## 95% CI [0.21, 2.04])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.16, 95% CI [-12.14, 34.46], t(2068) = 0.94, p = 0.348; Std. beta = 0.62,
## 95% CI [-0.84, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.83, 95% CI [-1.58, 33.23], t(2068) = 1.78, p = 0.075; Std. beta = 0.76,
## 95% CI [-0.30, 1.83])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.63, 95% CI [-22.83, 36.09], t(2068) = 0.44, p = 0.659; Std. beta = 0.67,
## 95% CI [-1.95, 3.28])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.54, 95% CI [-60.62, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.27, 0.50])
## - The effect of site [16R] is statistically significant and negative (beta =
## -15.23, 95% CI [-29.98, -0.48], t(2068) = -2.02, p = 0.043; Std. beta = -0.69,
## 95% CI [-1.62, 0.23])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-27.32, 38.85], t(2068) = 0.34, p = 0.733; Std. beta = 0.34,
## 95% CI [-1.61, 2.29])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-22.94, 23.94], t(2068) = 0.04, p = 0.967; Std. beta = 0.62,
## 95% CI [-1.50, 2.74])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-7.54, 23.14], t(2068) = 1.00, p = 0.319; Std. beta = 0.75, 95%
## CI [-0.30, 1.80])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-10.26, 17.13], t(2068) = 0.49, p = 0.623; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.37, 95% CI [-27.87, 36.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.65,
## 95% CI [-1.27, 2.57])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 0.99, 95% CI [-9.44, 11.42], t(2068) = 0.19, p = 0.852; Std. beta = -0.26,
## 95% CI [-0.95, 0.43])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.76, 4.19], t(2068) = -1.41, p = 0.158; Std. beta = -0.51,
## 95% CI [-1.65, 0.63])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.69, 95% CI [-7.00, 18.38], t(2068) = 0.88, p = 0.379; Std. beta = 0.33, 95%
## CI [-0.45, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 1.66, 95% CI [-11.97, 15.28], t(2068) = 0.24, p = 0.812; Std. beta = -0.48,
## 95% CI [-1.33, 0.36])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.75, 95% CI [-18.45, 19.95], t(2068) = 0.08, p = 0.939; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.18, 95% CI [-37.02, 28.66], t(2068) = -0.25, p = 0.803; Std. beta = -0.31,
## 95% CI [-2.24, 1.62])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-10.62, 18.63], t(2068) = 0.54, p = 0.591; Std. beta = 0.30,
## 95% CI [-0.57, 1.17])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 11.72, 95% CI [-4.91, 28.35], t(2068) = 1.38, p = 0.167; Std. beta = 0.33,
## 95% CI [-0.71, 1.37])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -15.98, 95% CI [-32.49, 0.53], t(2068) = -1.90, p = 0.058; Std. beta = -0.68,
## 95% CI [-1.78, 0.43])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-10.47, 14.78], t(2068) = 0.33, p = 0.738; Std. beta = 0.07,
## 95% CI [-0.71, 0.85])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 5.60, 95% CI [-13.68, 24.87], t(2068) = 0.57, p = 0.569; Std. beta = 1.37,
## 95% CI [0.16, 2.58])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.28, 2.26], t(2068) = -1.66, p = 0.097; Std. beta = -0.45,
## 95% CI [-1.38, 0.49])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 12.81, 95% CI [-3.54, 29.15], t(2068) = 1.54, p = 0.124; Std. beta = 0.54,
## 95% CI [-0.45, 1.53])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.48, 95% CI [1.40, 23.56], t(2068) = 2.21, p = 0.027; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.17, 95% CI [-14.66, 51.00], t(2068) = 1.09, p = 0.278; Std. beta = -3.05,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 28.70, 95% CI [5.59, 51.82], t(2068) = 2.43, p = 0.015; Std. beta = 1.68, 95%
## CI [0.20, 3.17])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.98, 95% CI [-20.02, 18.05], t(2068) = -0.10, p = 0.919; Std. beta = 0.04,
## 95% CI [-1.27, 1.36])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.50, 95% CI [-10.76, 9.75], t(2068) = -0.10, p = 0.923; Std. beta = 0.08,
## 95% CI [-0.88, 1.04])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.05, 95% CI [-0.72, 0.62], t(2068) =
## -0.15, p = 0.884; Std. beta = -4.90e-03, 95% CI [-0.07, 0.06])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.11, 95% CI [-43.97, 13.75], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.23, 11.43], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.13, 95% CI [-15.94, 5.68], t(2068) = -0.93, p = 0.352; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-13.06, 11.29], t(2068) = -0.14, p = 0.887;
## Std. beta = -0.10, 95% CI [-1.40, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-12.42, 6.48], t(2068) = -0.62, p = 0.538; Std.
## beta = -0.32, 95% CI [-1.33, 0.70])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.95, 95% CI [-6.67, -1.23], t(2068) = -2.84, p = 0.005; Std.
## beta = -0.42, 95% CI [-0.72, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.39, 95% CI [-14.66, 1.88], t(2068) = -1.51, p = 0.130; Std.
## beta = -0.69, 95% CI [-1.58, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.79, 95% CI [-2.92, 1.35], t(2068) = -0.72, p = 0.469; Std.
## beta = -0.08, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.61, 95% CI [-6.70, 1.48], t(2068) = -1.25, p = 0.211; Std.
## beta = -0.28, 95% CI [-0.72, 0.16])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 1.92, 95% CI [0.06, 3.77], t(2068) = 2.03, p = 0.043; Std.
## beta = 0.21, 95% CI [6.91e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.43, 95% CI [-0.32, 13.18], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.69, 95% CI [-0.03, 1.42])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-2.43, 1.70], t(2068) = -0.35, p = 0.728; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.05, 5.11], t(2068) = 1.29, p = 0.197; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.54, 20.70], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.60, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.48, 95% CI [0.46, 12.50], t(2068) = 2.11, p = 0.035; Std.
## beta = 0.70, 95% CI [0.05, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.06, 95% CI [-2.29, 8.41], t(2068) = 1.12, p = 0.262; Std.
## beta = 0.33, 95% CI [-0.25, 0.90])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-8.39, 7.63], t(2068) = -0.09, p = 0.925; Std.
## beta = -0.04, 95% CI [-0.90, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-9.78, 5.97], t(2068) = -0.47, p = 0.635; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-34.02, 40.17], t(2068) = 0.16, p = 0.871; Std.
## beta = 0.33, 95% CI [-3.65, 4.32])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-25.19, 19.34], t(2068) = -0.26, p = 0.796;
## Std. beta = -0.31, 95% CI [-2.71, 2.08])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-2.82, 7.46], t(2068) = 0.88, p = 0.377; Std.
## beta = 0.25, 95% CI [-0.30, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.61, 95% CI [-14.50, 27.72], t(2068) = 0.61, p = 0.539; Std.
## beta = 0.71, 95% CI [-1.56, 2.98])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.22, 95% CI [-5.03, 11.47], t(2068) = 0.77, p = 0.444; Std.
## beta = 0.35, 95% CI [-0.54, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.41, 6.95], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.44, 95% CI [-4.37, 13.25], t(2068) = 0.99, p = 0.323; Std.
## beta = 0.48, 95% CI [-0.47, 1.42])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.58, 95% CI [-8.81, 1.65], t(2068) = -1.34, p = 0.179; Std.
## beta = -0.38, 95% CI [-0.95, 0.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-8.41, 11.18], t(2068) = 0.28, p = 0.782; Std.
## beta = 0.15, 95% CI [-0.90, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-4.64, 4.46], t(2068) = -0.04, p = 0.969; Std.
## beta = -9.65e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.50, 95% CI [-11.80, -1.20], t(2068) = -2.40, p = 0.016;
## Std. beta = -0.70, 95% CI [-1.27, -0.13])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.39, 95% CI [-32.88, 10.10], t(2068) = -1.04, p = 0.299;
## Std. beta = -1.22, 95% CI [-3.53, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.67, 95% CI [-9.92, 8.57], t(2068) = -0.14, p = 0.886; Std.
## beta = -0.07, 95% CI [-1.07, 0.92])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.68, 95% CI [-3.11, 4.47], t(2068) = 0.35, p = 0.725; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-10.46, 2.33], t(2068) = -1.25, p = 0.213; Std.
## beta = -0.44, 95% CI [-1.12, 0.25])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.54, 10.52], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.32, 95% CI [-0.49, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.18, 3.97], t(2068) = -0.26, p = 0.795; Std.
## beta = -0.07, 95% CI [-0.56, 0.43])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.66, 95% CI [3.54, 19.78], t(2068) = 2.82, p = 0.005; Std.
## beta = 1.25, 95% CI [0.38, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.25, 8.80], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-7.73, 2.93], t(2068) = -0.88, p = 0.378; Std.
## beta = -0.26, 95% CI [-0.83, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.07, 95% CI [-6.65, 0.51], t(2068) = -1.68, p = 0.093; Std.
## beta = -0.33, 95% CI [-0.71, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.21, 95% CI [-62.97, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-8.89, 8.63], t(2068) = -0.03, p = 0.977; Std.
## beta = -0.01, 95% CI [-0.95, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-9.68, 11.95], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.12, 95% CI [-1.04, 1.28])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-9.36, 11.75], t(2068) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*OM_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14375.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2917 -0.4414 -0.0118 0.4477 4.5138
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 233.50 15.281
## time_firstPFT 13.58 3.685 -0.07
## Residual 25.62 5.062
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 31.86588 6.54156 4.871
## time_firstPFT -1.23599 2.43295 -0.508
## OM_5yrPreCensor 0.08613 0.92136 0.093
## disadv 3.99613 2.89799 1.379
## dich_RaceNon-White -7.39143 2.81351 -2.627
## sexF 3.77198 1.74872 2.157
## age_dx 0.38513 0.09134 4.217
## smokeHxFormer 3.64686 1.73183 2.106
## smokeHxAlways 18.54400 8.46325 2.191
## smokeHxUnknown -2.53314 3.93466 -0.644
## site02R -11.30767 16.20413 -0.698
## site03R 11.82648 11.71977 1.009
## site04R 2.89456 11.28889 0.256
## site05R -12.63999 9.37231 -1.349
## site06R 10.36286 16.23060 0.638
## site07R 11.54626 4.62194 2.498
## site09R 20.40071 11.40810 1.788
## site101 4.24886 3.25259 1.306
## site102 12.34830 6.17923 1.998
## site103 -1.41122 2.78629 -0.506
## site104 -7.10212 6.30420 -1.127
## site105 4.39106 3.09133 1.420
## site106 -5.63564 4.12186 -1.367
## site107 -2.21663 11.49176 -0.193
## site108 5.08785 9.72259 0.523
## site10R 11.98143 17.08432 0.701
## site11R 10.44272 7.18174 1.454
## site12R 7.21430 11.39829 0.633
## site13R 17.37043 8.58968 2.022
## site14R 5.91636 14.66353 0.403
## site15R -34.19574 16.23030 -2.107
## site16R -9.04658 7.32045 -1.236
## site17R 10.00807 16.33217 0.613
## site18R -3.38857 11.51304 -0.294
## site19R 8.08232 7.58201 1.066
## site20R 2.20806 6.71698 0.329
## site21R 2.50042 15.72322 0.159
## site22R -2.64384 5.20386 -0.508
## site23R -13.32256 8.84356 -1.506
## site24R 4.83960 6.20981 0.779
## site25R 0.63618 6.75749 0.094
## site28R 4.03196 9.45565 0.426
## site29R -6.24872 16.09015 -0.388
## site31R 5.35537 7.22058 0.742
## site32R 9.43313 8.19653 1.151
## site33R -14.14701 8.11332 -1.744
## site34R -0.02119 6.18574 -0.003
## site35R -0.44648 9.47497 -0.047
## site36R -11.50369 7.25618 -1.585
## site37R 15.48027 8.09587 1.912
## site38R 12.27629 5.42847 2.261
## site39R 23.86304 16.34950 1.460
## site40R 25.59791 11.32117 2.261
## site41R -3.13203 9.38699 -0.334
## site42R -1.00189 5.09462 -0.197
## time_firstPFT:OM_5yrPreCensor -0.01565 0.36285 -0.043
## time_firstPFT:disadv 0.03221 1.12047 0.029
## time_firstPFT:dich_RaceNon-White 0.11078 1.11619 0.099
## time_firstPFT:sexF 0.02246 0.66407 0.034
## time_firstPFT:age_dx -0.06053 0.03467 -1.746
## time_firstPFT:smokeHxFormer 0.54764 0.67562 0.811
## time_firstPFT:smokeHxAlways 1.38208 5.32766 0.259
## time_firstPFT:smokeHxUnknown 1.60769 1.68703 0.953
## time_firstPFT:site02R -14.29753 14.76656 -0.968
## time_firstPFT:site03R 2.97216 5.09249 0.584
## time_firstPFT:site04R -4.68129 5.59649 -0.836
## time_firstPFT:site05R -0.52167 6.25287 -0.083
## time_firstPFT:site07R -3.37348 1.45180 -2.324
## time_firstPFT:site09R -6.18159 4.31759 -1.432
## time_firstPFT:site101 -0.57171 1.12832 -0.507
## time_firstPFT:site102 -2.64866 2.14318 -1.236
## time_firstPFT:site103 2.13020 1.01219 2.105
## time_firstPFT:site104 6.89331 3.53343 1.951
## time_firstPFT:site105 -0.28172 1.08301 -0.260
## time_firstPFT:site106 2.70262 1.63899 1.649
## time_firstPFT:site107 7.75700 6.73109 1.152
## time_firstPFT:site108 6.51554 3.32383 1.960
## time_firstPFT:site11R 3.95021 2.82424 1.399
## time_firstPFT:site12R 0.08184 4.17904 0.020
## time_firstPFT:site13R -1.29354 4.09742 -0.316
## time_firstPFT:site14R 3.58615 18.95336 0.189
## time_firstPFT:site15R -2.68723 11.40374 -0.236
## time_firstPFT:site16R 2.09764 2.71991 0.771
## time_firstPFT:site18R 7.09740 10.81118 0.656
## time_firstPFT:site19R 4.63658 4.31191 1.075
## time_firstPFT:site20R 1.65065 3.23167 0.511
## time_firstPFT:site21R 4.59519 4.57722 1.004
## time_firstPFT:site22R -2.57645 2.73839 -0.941
## time_firstPFT:site23R 9.40458 24.71159 0.381
## time_firstPFT:site24R 0.04846 2.35991 0.021
## time_firstPFT:site25R -5.66087 2.78997 -2.029
## time_firstPFT:site28R -9.84730 11.08061 -0.889
## time_firstPFT:site29R 0.06895 4.81913 0.014
## time_firstPFT:site31R 0.86608 2.01398 0.430
## time_firstPFT:site32R -3.33653 3.34263 -0.998
## time_firstPFT:site33R 3.63565 3.96120 0.918
## time_firstPFT:site34R -0.35527 2.40380 -0.148
## time_firstPFT:site35R 12.64618 4.23811 2.984
## time_firstPFT:site36R 3.63095 2.88083 1.260
## time_firstPFT:site37R -1.60719 2.85098 -0.564
## time_firstPFT:site38R -2.79674 1.86533 -1.499
## time_firstPFT:site39R -46.67027 8.68335 -5.375
## time_firstPFT:site40R 1.08359 4.60993 0.235
## time_firstPFT:site41R 1.99210 5.56915 0.358
## time_firstPFT:site42R 2.20015 5.40396 0.407##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.694report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## OM_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 31.87 (95% CI [19.04, 44.69], t(2038)
## = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## OM_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to
## OM_5yrPreCensor = 0, is at 31.87 (95% CI [19.04, 44.69], t(2038) = 4.87, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 31.87 (95% CI [19.04,
## 44.69], t(2038) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to dich_Race =
## White, is at 31.87 (95% CI [19.04, 44.69], t(2038) = 4.87, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 31.87 (95% CI [19.04,
## 44.69], t(2038) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 31.87 (95% CI [19.04,
## 44.69], t(2038) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 31.87 (95% CI
## [19.04, 44.69], t(2038) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 31.87 (95% CI [19.04,
## 44.69], t(2038) = 4.87, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to cohort =
## CARE-PF, is at 31.87 (95% CI [19.04, 44.69], t(2038) = 4.87, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.24, 95% CI [-6.01, 3.54], t(2038) = -0.51, p = 0.611; Std. beta =
## -0.52, 95% CI [-0.68, -0.36])
## - The effect of OM 5yrPreCensor is statistically non-significant and positive
## (beta = 0.09, 95% CI [-1.72, 1.89], t(2038) = 0.09, p = 0.926; Std. beta =
## 3.34e-03, 95% CI [-0.10, 0.11])
## - The effect of disadv is statistically non-significant and positive (beta =
## 4.00, 95% CI [-1.69, 9.68], t(2038) = 1.38, p = 0.168; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.39, 95% CI [-12.91, -1.87], t(2038) = -2.63, p = 0.009; Std. beta =
## -0.43, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.77,
## 95% CI [0.34, 7.20], t(2038) = 2.16, p = 0.031; Std. beta = 0.22, 95% CI
## [6.58e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.56], t(2038) = 4.22, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.65, 95% CI [0.25, 7.04], t(2038) = 2.11, p = 0.035; Std. beta = 0.26,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.54, 95% CI [1.95, 35.14], t(2038) = 2.19, p = 0.029; Std. beta =
## 1.22, 95% CI [2.08e-03, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.53, 95% CI [-10.25, 5.18], t(2038) = -0.64, p = 0.520; Std. beta =
## -5.49e-03, 95% CI [-0.51, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.31, 95% CI [-43.09, 20.47], t(2038) = -0.70, p = 0.485; Std. beta =
## -1.95, 95% CI [-4.73, 0.83])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.83, 95% CI [-11.16, 34.81], t(2038) = 1.01, p = 0.313; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-19.24, 25.03], t(2038) = 0.26, p = 0.798; Std. beta = -0.25,
## 95% CI [-1.74, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.64, 95% CI [-31.02, 5.74], t(2038) = -1.35, p = 0.178; Std. beta = -0.79,
## 95% CI [-2.16, 0.57])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.47, 42.19], t(2038) = 0.64, p = 0.523; Std. beta = 0.61,
## 95% CI [-1.27, 2.49])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.55, 95% CI [2.48, 20.61], t(2038) = 2.50, p = 0.013; Std. beta = 0.38, 95%
## CI [-0.18, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 20.40, 95% CI [-1.97, 42.77], t(2038) = 1.79, p = 0.074; Std. beta = 0.65,
## 95% CI [-0.79, 2.09])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-2.13, 10.63], t(2038) = 1.31, p = 0.192; Std. beta = 0.20, 95%
## CI [-0.20, 0.60])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.35, 95% CI [0.23, 24.47], t(2038) = 2.00, p = 0.046; Std. beta = 0.49, 95%
## CI [-0.26, 1.24])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.41, 95% CI [-6.88, 4.05], t(2038) = -0.51, p = 0.613; Std. beta = 0.11,
## 95% CI [-0.24, 0.45])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.47, 5.26], t(2038) = -1.13, p = 0.260; Std. beta = 0.20,
## 95% CI [-0.69, 1.08])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.39, 95% CI [-1.67, 10.45], t(2038) = 1.42, p = 0.156; Std. beta = 0.23, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-13.72, 2.45], t(2038) = -1.37, p = 0.172; Std. beta = -0.09,
## 95% CI [-0.59, 0.41])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-24.75, 20.32], t(2038) = -0.19, p = 0.847; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 5.09, 95% CI [-13.98, 24.16], t(2038) = 0.52, p = 0.601; Std. beta = 0.88,
## 95% CI [-0.29, 2.05])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 11.98, 95% CI [-21.52, 45.49], t(2038) = 0.70, p = 0.483; Std. beta = 0.71,
## 95% CI [-1.27, 2.68])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.44, 95% CI [-3.64, 24.53], t(2038) = 1.45, p = 0.146; Std. beta = 0.97,
## 95% CI [0.07, 1.87])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-15.14, 29.57], t(2038) = 0.63, p = 0.527; Std. beta = 0.43,
## 95% CI [-1.01, 1.87])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.37, 95% CI [0.52, 34.22], t(2038) = 2.02, p = 0.043; Std. beta = 0.91, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 5.92, 95% CI [-22.84, 34.67], t(2038) = 0.40, p = 0.687; Std. beta = 0.67,
## 95% CI [-1.94, 3.28])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.20, 95% CI [-66.03, -2.37], t(2038) = -2.11, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.05, 95% CI [-23.40, 5.31], t(2038) = -1.24, p = 0.217; Std. beta = -0.35,
## 95% CI [-1.27, 0.58])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-22.02, 42.04], t(2038) = 0.61, p = 0.540; Std. beta = 0.59,
## 95% CI [-1.30, 2.48])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.39, 95% CI [-25.97, 19.19], t(2038) = -0.29, p = 0.769; Std. beta = 0.44,
## 95% CI [-1.67, 2.54])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.08, 95% CI [-6.79, 22.95], t(2038) = 1.07, p = 0.287; Std. beta = 0.89, 95%
## CI [-0.16, 1.94])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-10.96, 15.38], t(2038) = 0.33, p = 0.742; Std. beta = 0.28,
## 95% CI [-0.60, 1.15])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.50, 95% CI [-28.33, 33.34], t(2038) = 0.16, p = 0.874; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -2.64, 95% CI [-12.85, 7.56], t(2038) = -0.51, p = 0.611; Std. beta = -0.39,
## 95% CI [-1.08, 0.30])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -13.32, 95% CI [-30.67, 4.02], t(2038) = -1.51, p = 0.132; Std. beta = 0.06,
## 95% CI [-4.00, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.84, 95% CI [-7.34, 17.02], t(2038) = 0.78, p = 0.436; Std. beta = 0.29, 95%
## CI [-0.47, 1.05])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.64, 95% CI [-12.62, 13.89], t(2038) = 0.09, p = 0.925; Std. beta = -0.47,
## 95% CI [-1.31, 0.37])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 4.03, 95% CI [-14.51, 22.58], t(2038) = 0.43, p = 0.670; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.25, 95% CI [-37.80, 25.31], t(2038) = -0.39, p = 0.698; Std. beta = -0.36,
## 95% CI [-2.25, 1.52])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-8.81, 19.52], t(2038) = 0.74, p = 0.458; Std. beta = 0.39, 95%
## CI [-0.46, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.64, 25.51], t(2038) = 1.15, p = 0.250; Std. beta = 0.26, 95%
## CI [-0.77, 1.29])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.15, 95% CI [-30.06, 1.76], t(2038) = -1.74, p = 0.081; Std. beta = -0.51,
## 95% CI [-1.60, 0.58])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-12.15, 12.11], t(2038) = -3.42e-03, p = 0.997; Std. beta =
## -0.03, 95% CI [-0.80, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-19.03, 18.14], t(2038) = -0.05, p = 0.962; Std. beta = 1.11,
## 95% CI [-0.09, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.73, 2.73], t(2038) = -1.59, p = 0.113; Std. beta = -0.35,
## 95% CI [-1.27, 0.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.48, 95% CI [-0.40, 31.36], t(2038) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.22, 1.75])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.28, 95% CI [1.63, 22.92], t(2038) = 2.26, p = 0.024; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.86, 95% CI [-8.20, 55.93], t(2038) = 1.46, p = 0.145; Std. beta = -2.77,
## 95% CI [-4.93, -0.61])
## - The effect of site [40R] is statistically significant and positive (beta =
## 25.60, 95% CI [3.40, 47.80], t(2038) = 2.26, p = 0.024; Std. beta = 1.61, 95%
## CI [0.14, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -3.13, 95% CI [-21.54, 15.28], t(2038) = -0.33, p = 0.739; Std. beta =
## -6.40e-03, 95% CI [-1.31, 1.30])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -1.00, 95% CI [-10.99, 8.99], t(2038) = -0.20, p = 0.844; Std. beta = 0.14,
## 95% CI [-0.83, 1.10])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and negative (beta = -0.02, 95% CI [-0.73, 0.70], t(2038) =
## -0.04, p = 0.966; Std. beta = -1.53e-03, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.17, 2.23], t(2038) = 0.03, p = 0.977; Std.
## beta = 9.87e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.11, 95% CI [-2.08, 2.30], t(2038) =
## 0.10, p = 0.921; Std. beta = 0.01, 95% CI [-0.22, 0.25])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.02, 95% CI [-1.28, 1.32], t(2038) = 0.03, p = 0.973; Std.
## beta = 2.42e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.48e-03], t(2038) = -1.75, p = 0.081;
## Std. beta = -0.06, 95% CI [-0.13, 7.42e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.55, 95% CI [-0.78, 1.87], t(2038) =
## 0.81, p = 0.418; Std. beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.38, 95% CI [-9.07, 11.83], t(2038) =
## 0.26, p = 0.795; Std. beta = 0.15, 95% CI [-0.98, 1.27])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.61, 95% CI [-1.70, 4.92], t(2038) =
## 0.95, p = 0.341; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.66], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.97, 95% CI [-7.01, 12.96], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.32, 95% CI [-0.76, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.68, 95% CI [-15.66, 6.29], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.50, 95% CI [-1.69, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-12.78, 11.74], t(2038) = -0.08, p = 0.934;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.37, 95% CI [-6.22, -0.53], t(2038) = -2.32, p = 0.020; Std.
## beta = -0.36, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.18, 95% CI [-14.65, 2.29], t(2038) = -1.43, p = 0.152; Std.
## beta = -0.67, 95% CI [-1.58, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-2.78, 1.64], t(2038) = -0.51, p = 0.612; Std.
## beta = -0.06, 95% CI [-0.30, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-6.85, 1.55], t(2038) = -1.24, p = 0.217; Std.
## beta = -0.29, 95% CI [-0.74, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.13, 95% CI [0.15, 4.12], t(2038) = 2.10, p = 0.035; Std.
## beta = 0.23, 95% CI [0.02, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.89, 95% CI [-0.04, 13.82], t(2038) = 1.95, p = 0.051; Std.
## beta = 0.74, 95% CI [-3.89e-03, 1.49])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.84], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.03, 95% CI [-0.26, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-0.51, 5.92], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.29, 95% CI [-0.06, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.76, 95% CI [-5.44, 20.96], t(2038) = 1.15, p = 0.249; Std.
## beta = 0.84, 95% CI [-0.59, 2.26])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.52, 95% CI [-2.93e-03, 13.03], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.70, 95% CI [-3.10e-04, 1.40])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-1.59, 9.49], t(2038) = 1.40, p = 0.162; Std.
## beta = 0.43, 95% CI [-0.17, 1.02])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.08, 95% CI [-8.11, 8.28], t(2038) = 0.02, p = 0.984; Std.
## beta = 8.81e-03, 95% CI [-0.87, 0.89])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.29, 95% CI [-9.33, 6.74], t(2038) = -0.32, p = 0.752; Std.
## beta = -0.14, 95% CI [-1.00, 0.73])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-33.58, 40.76], t(2038) = 0.19, p = 0.850; Std.
## beta = 0.39, 95% CI [-3.62, 4.39])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-25.05, 19.68], t(2038) = -0.24, p = 0.814;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-3.24, 7.43], t(2038) = 0.77, p = 0.441; Std.
## beta = 0.23, 95% CI [-0.35, 0.80])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 7.10, 95% CI [-14.10, 28.30], t(2038) = 0.66, p = 0.512; Std.
## beta = 0.76, 95% CI [-1.52, 3.05])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-3.82, 13.09], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.41])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-4.69, 7.99], t(2038) = 0.51, p = 0.610; Std.
## beta = 0.18, 95% CI [-0.50, 0.86])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-4.38, 13.57], t(2038) = 1.00, p = 0.316; Std.
## beta = 0.49, 95% CI [-0.47, 1.46])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.95, 2.79], t(2038) = -0.94, p = 0.347; Std.
## beta = -0.28, 95% CI [-0.86, 0.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.40, 95% CI [-39.06, 57.87], t(2038) = 0.38, p = 0.704; Std.
## beta = 1.01, 95% CI [-4.21, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.58, 4.68], t(2038) = 0.02, p = 0.984; Std.
## beta = 5.22e-03, 95% CI [-0.49, 0.50])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.66, 95% CI [-11.13, -0.19], t(2038) = -2.03, p = 0.043;
## Std. beta = -0.61, 95% CI [-1.20, -0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.85, 95% CI [-31.58, 11.88], t(2038) = -0.89, p = 0.374;
## Std. beta = -1.06, 95% CI [-3.40, 1.28])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-9.38, 9.52], t(2038) = 0.01, p = 0.989; Std.
## beta = 7.43e-03, 95% CI [-1.01, 1.03])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.08, 4.82], t(2038) = 0.43, p = 0.667; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-9.89, 3.22], t(2038) = -1.00, p = 0.318; Std.
## beta = -0.36, 95% CI [-1.07, 0.35])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-4.13, 11.40], t(2038) = 0.92, p = 0.359; Std.
## beta = 0.39, 95% CI [-0.45, 1.23])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-5.07, 4.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.04, 95% CI [-0.55, 0.47])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.65, 95% CI [4.33, 20.96], t(2038) = 2.98, p = 0.003; Std.
## beta = 1.36, 95% CI [0.47, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.63, 95% CI [-2.02, 9.28], t(2038) = 1.26, p = 0.208; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.61, 95% CI [-7.20, 3.98], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.78, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-6.45, 0.86], t(2038) = -1.50, p = 0.134; Std.
## beta = -0.30, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.67, 95% CI [-63.70, -29.64], t(2038) = -5.37, p < .001;
## Std. beta = -5.03, 95% CI [-6.86, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.96, 10.12], t(2038) = 0.24, p = 0.814; Std.
## beta = 0.12, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.99, 95% CI [-8.93, 12.91], t(2038) = 0.36, p = 0.721; Std.
## beta = 0.21, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-8.40, 12.80], t(2038) = 0.41, p = 0.684; Std.
## beta = 0.24, 95% CI [-0.90, 1.38])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*SS_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14559
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3218 -0.4420 -0.0145 0.4483 4.5355
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 257.04 16.032
## time_firstPFT 12.95 3.599 -0.11
## Residual 25.58 5.058
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 60.68121 1.93057 31.432
## time_firstPFT -4.40093 0.67887 -6.483
## SS_5yrPreCensor -5.60169 6.91927 -0.810
## site02R 5.17490 23.26151 0.222
## site03R 13.62347 12.07310 1.128
## site04R 3.42887 11.76509 0.291
## site05R -11.67323 9.73678 -1.199
## site06R 19.95505 11.95943 1.669
## site07R 12.84446 4.73771 2.711
## site09R 23.01089 11.94627 1.926
## site101 3.33979 3.22783 1.035
## site102 10.41728 6.39551 1.629
## site103 -0.51684 2.76931 -0.187
## site104 -5.37463 6.45156 -0.833
## site105 4.70919 3.16292 1.489
## site106 -3.52029 4.19531 -0.839
## site107 -4.78955 11.91961 -0.402
## site108 -0.59891 9.65190 -0.062
## site10R 19.52302 20.22450 0.965
## site11R 14.59353 7.44457 1.960
## site12R 11.00338 11.82673 0.930
## site13R 15.91535 8.86057 1.796
## site14R 7.97955 15.03942 0.531
## site15R -27.51454 16.86018 -1.632
## site16R -13.98052 7.61055 -1.837
## site17R 5.50416 16.86748 0.326
## site18R 2.21447 12.12236 0.183
## site19R 8.29093 7.60707 1.090
## site20R 3.21550 6.97043 0.461
## site21R 4.27388 16.41429 0.260
## site22R 2.25246 5.40037 0.417
## site23R -9.78994 7.67821 -1.275
## site24R 5.66060 6.40399 0.884
## site25R 9.18569 11.55176 0.795
## site28R 0.55557 9.78972 0.057
## site29R -1.73630 16.87926 -0.103
## site31R 4.18840 7.44211 0.563
## site32R 12.26436 8.40224 1.460
## site33R -14.02552 8.62744 -1.626
## site34R 2.62876 6.38004 0.412
## site35R 6.21744 9.75773 0.637
## site36R -12.59586 7.52875 -1.673
## site37R 13.18639 8.32932 1.583
## site38R 12.53642 5.64506 2.221
## site39R 17.87288 16.70642 1.070
## site40R 29.69084 11.85603 2.504
## site41R 0.02321 9.74815 0.002
## site42R 0.23452 5.25022 0.045
## time_firstPFT:SS_5yrPreCensor 1.28840 2.59280 0.497
## time_firstPFT:site02R -18.12348 15.91393 -1.139
## time_firstPFT:site03R 1.59724 5.00792 0.319
## time_firstPFT:site04R -5.11427 5.50079 -0.930
## time_firstPFT:site05R -0.76122 6.20744 -0.123
## time_firstPFT:site06R -3.05286 4.77709 -0.639
## time_firstPFT:site07R -3.96693 1.37479 -2.885
## time_firstPFT:site09R -6.68047 4.24882 -1.572
## time_firstPFT:site101 -0.80651 1.05625 -0.764
## time_firstPFT:site102 -2.46054 2.08805 -1.178
## time_firstPFT:site103 1.83468 0.95690 1.917
## time_firstPFT:site104 6.33890 3.44309 1.841
## time_firstPFT:site105 -0.39934 1.05203 -0.380
## time_firstPFT:site106 1.97217 1.57363 1.253
## time_firstPFT:site107 7.57810 6.68281 1.134
## time_firstPFT:site108 6.74709 3.05501 2.209
## time_firstPFT:site11R 2.86936 2.71701 1.056
## time_firstPFT:site12R -0.24686 4.07010 -0.061
## time_firstPFT:site13R -1.86917 4.00809 -0.466
## time_firstPFT:site14R 2.89839 18.91604 0.153
## time_firstPFT:site15R -2.98468 11.35205 -0.263
## time_firstPFT:site16R 2.13663 2.64514 0.808
## time_firstPFT:site18R 6.21116 10.78049 0.576
## time_firstPFT:site19R 3.23929 4.17788 0.775
## time_firstPFT:site20R 0.90047 3.14552 0.286
## time_firstPFT:site21R 4.33401 4.47891 0.968
## time_firstPFT:site22R -3.87358 2.75129 -1.408
## time_firstPFT:site23R 1.12769 5.01879 0.225
## time_firstPFT:site24R 0.04783 2.30282 0.021
## time_firstPFT:site25R -8.11947 4.21501 -1.926
## time_firstPFT:site28R -11.30982 10.95768 -1.032
## time_firstPFT:site29R -1.09194 4.78905 -0.228
## time_firstPFT:site31R 0.69200 1.92491 0.359
## time_firstPFT:site32R -4.18025 3.26965 -1.278
## time_firstPFT:site33R 2.69806 3.87966 0.695
## time_firstPFT:site34R -0.61322 2.31787 -0.265
## time_firstPFT:site35R 11.71814 4.11072 2.851
## time_firstPFT:site36R 3.27988 2.81258 1.166
## time_firstPFT:site37R -2.48061 2.72096 -0.912
## time_firstPFT:site38R -3.11356 1.82429 -1.707
## time_firstPFT:site39R -45.97406 8.53629 -5.386
## time_firstPFT:site40R -0.02656 4.42601 -0.006
## time_firstPFT:site41R 0.93076 5.53051 0.168
## time_firstPFT:site42R 1.14533 5.39007 0.212##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.924
## Unadjusted ICC: 0.730report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SS_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.21. The model's
## intercept, corresponding to time_firstPFT = 0, is at 60.68 (95% CI [56.90,
## 64.47], t(2068) = 31.43, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.40, 95% CI [-5.73, -3.07], t(2068) = -6.48, p < .001; Std. beta = -0.44, 95%
## CI [-0.54, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -5.60, 95% CI [-19.17, 7.97], t(2068) = -0.81, p = 0.418; Std. beta =
## -0.04, 95% CI [-0.20, 0.12])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-40.44, 50.79], t(2068) = 0.22, p = 0.824; Std. beta = -1.31,
## 95% CI [-4.73, 2.11])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.05, 37.30], t(2068) = 1.13, p = 0.259; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-19.64, 26.50], t(2068) = 0.29, p = 0.771; Std. beta = -0.25,
## 95% CI [-1.77, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-30.77, 7.42], t(2068) = -1.20, p = 0.231; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.96, 95% CI [-3.50, 43.41], t(2068) = 1.67, p = 0.095; Std. beta = 0.90,
## 95% CI [-0.60, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.84, 95% CI [3.55, 22.14], t(2068) = 2.71, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.15, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.01, 95% CI [-0.42, 46.44], t(2068) = 1.93, p = 0.054; Std. beta = 0.76,
## 95% CI [-0.71, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.34, 95% CI [-2.99, 9.67], t(2068) = 1.03, p = 0.301; Std. beta = 0.13, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-2.13, 22.96], t(2068) = 1.63, p = 0.103; Std. beta = 0.40,
## 95% CI [-0.37, 1.16])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-5.95, 4.91], t(2068) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.20, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.37, 95% CI [-18.03, 7.28], t(2068) = -0.83, p = 0.405; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.71, 95% CI [-1.49, 10.91], t(2068) = 1.49, p = 0.137; Std. beta = 0.24, 95%
## CI [-0.14, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.52, 95% CI [-11.75, 4.71], t(2068) = -0.84, p = 0.402; Std. beta = -0.03,
## 95% CI [-0.53, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-28.17, 18.59], t(2068) = -0.40, p = 0.688; Std. beta = 0.39,
## 95% CI [-1.19, 1.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-19.53, 18.33], t(2068) = -0.06, p = 0.951; Std. beta = 0.57,
## 95% CI [-0.57, 1.70])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 19.52, 95% CI [-20.14, 59.19], t(2068) = 0.97, p = 0.334; Std. beta = 1.15,
## 95% CI [-1.19, 3.49])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-6.11e-03, 29.19], t(2068) = 1.96, p = 0.050; Std. beta =
## 1.12, 95% CI [0.20, 2.03])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.00, 95% CI [-12.19, 34.20], t(2068) = 0.93, p = 0.352; Std. beta = 0.63,
## 95% CI [-0.83, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.92, 95% CI [-1.46, 33.29], t(2068) = 1.80, p = 0.073; Std. beta = 0.77,
## 95% CI [-0.29, 1.84])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.98, 95% CI [-21.51, 37.47], t(2068) = 0.53, p = 0.596; Std. beta = 0.73,
## 95% CI [-1.89, 3.35])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.51, 95% CI [-60.58, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.28, 0.50])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-28.91, 0.94], t(2068) = -1.84, p = 0.066; Std. beta = -0.63,
## 95% CI [-1.57, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-27.57, 38.58], t(2068) = 0.33, p = 0.744; Std. beta = 0.32,
## 95% CI [-1.63, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-21.56, 25.99], t(2068) = 0.18, p = 0.855; Std. beta = 0.68,
## 95% CI [-1.45, 2.81])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-6.63, 23.21], t(2068) = 1.09, p = 0.276; Std. beta = 0.78, 95%
## CI [-0.25, 1.81])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.45, 16.89], t(2068) = 0.46, p = 0.645; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-27.92, 36.46], t(2068) = 0.26, p = 0.795; Std. beta = 0.64,
## 95% CI [-1.28, 2.56])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-8.34, 12.84], t(2068) = 0.42, p = 0.677; Std. beta = -0.21,
## 95% CI [-0.92, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -9.79, 95% CI [-24.85, 5.27], t(2068) = -1.28, p = 0.202; Std. beta = -0.48,
## 95% CI [-1.62, 0.67])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-6.90, 18.22], t(2068) = 0.88, p = 0.377; Std. beta = 0.34, 95%
## CI [-0.43, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 9.19, 95% CI [-13.47, 31.84], t(2068) = 0.80, p = 0.427; Std. beta = -0.18,
## 95% CI [-1.57, 1.21])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-18.64, 19.75], t(2068) = 0.06, p = 0.955; Std. beta = -0.98,
## 95% CI [-3.05, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.74, 95% CI [-34.84, 31.37], t(2068) = -0.10, p = 0.918; Std. beta = -0.20,
## 95% CI [-2.15, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.19, 95% CI [-10.41, 18.78], t(2068) = 0.56, p = 0.574; Std. beta = 0.31,
## 95% CI [-0.56, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-4.21, 28.74], t(2068) = 1.46, p = 0.145; Std. beta = 0.35,
## 95% CI [-0.68, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.03, 95% CI [-30.94, 2.89], t(2068) = -1.63, p = 0.104; Std. beta = -0.59,
## 95% CI [-1.71, 0.54])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.88, 15.14], t(2068) = 0.41, p = 0.680; Std. beta = 0.10, 95%
## CI [-0.67, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.22, 95% CI [-12.92, 25.35], t(2068) = 0.64, p = 0.524; Std. beta = 1.41,
## 95% CI [0.20, 2.62])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.60, 95% CI [-27.36, 2.17], t(2068) = -1.67, p = 0.094; Std. beta = -0.45,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.19, 95% CI [-3.15, 29.52], t(2068) = 1.58, p = 0.114; Std. beta = 0.56,
## 95% CI [-0.44, 1.55])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.54, 95% CI [1.47, 23.61], t(2068) = 2.22, p = 0.026; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.87, 95% CI [-14.89, 50.64], t(2068) = 1.07, p = 0.285; Std. beta = -3.04,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 29.69, 95% CI [6.44, 52.94], t(2068) = 2.50, p = 0.012; Std. beta = 1.75, 95%
## CI [0.26, 3.24])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 0.02, 95% CI [-19.09, 19.14], t(2068) = 2.38e-03, p = 0.998; Std. beta =
## 0.08, 95% CI [-1.24, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-10.06, 10.53], t(2068) = 0.04, p = 0.964; Std. beta = 0.12,
## 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.29, 95% CI [-3.80, 6.37], t(2068) =
## 0.50, p = 0.619; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -18.12, 95% CI [-49.33, 13.09], t(2068) = -1.14, p = 0.255;
## Std. beta = -1.95, 95% CI [-5.30, 1.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.22, 11.42], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.11, 95% CI [-15.90, 5.67], t(2068) = -0.93, p = 0.353; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-12.93, 11.41], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-12.42, 6.32], t(2068) = -0.64, p = 0.523; Std.
## beta = -0.33, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.97, 95% CI [-6.66, -1.27], t(2068) = -2.89, p = 0.004; Std.
## beta = -0.43, 95% CI [-0.72, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.68, 95% CI [-15.01, 1.65], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-2.88, 1.26], t(2068) = -0.76, p = 0.445; Std.
## beta = -0.09, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-6.56, 1.63], t(2068) = -1.18, p = 0.239; Std.
## beta = -0.26, 95% CI [-0.70, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-0.04, 3.71], t(2068) = 1.92, p = 0.055; Std.
## beta = 0.20, 95% CI [-4.50e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.34, 95% CI [-0.41, 13.09], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.68, 95% CI [-0.04, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.46, 1.66], t(2068) = -0.38, p = 0.704; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-1.11, 5.06], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.21, 95% CI [-0.12, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.53, 20.68], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.59, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.75, 95% CI [0.76, 12.74], t(2068) = 2.21, p = 0.027; Std.
## beta = 0.72, 95% CI [0.08, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-2.46, 8.20], t(2068) = 1.06, p = 0.291; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-8.23, 7.74], t(2068) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.88, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-9.73, 5.99], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-34.20, 39.99], t(2068) = 0.15, p = 0.878; Std.
## beta = 0.31, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.98, 95% CI [-25.25, 19.28], t(2068) = -0.26, p = 0.793;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-3.05, 7.32], t(2068) = 0.81, p = 0.419; Std.
## beta = 0.23, 95% CI [-0.33, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-14.93, 27.35], t(2068) = 0.58, p = 0.565; Std.
## beta = 0.67, 95% CI [-1.60, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.95, 11.43], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.35, 95% CI [-0.53, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.27, 7.07], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.10, 95% CI [-0.57, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.45, 13.12], t(2068) = 0.97, p = 0.333; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-9.27, 1.52], t(2068) = -1.41, p = 0.159; Std.
## beta = -0.42, 95% CI [-1.00, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-8.71, 10.97], t(2068) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.94, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.47, 4.56], t(2068) = 0.02, p = 0.983; Std.
## beta = 5.17e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -8.12, 95% CI [-16.39, 0.15], t(2068) = -1.93, p = 0.054; Std.
## beta = -0.87, 95% CI [-1.76, 0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.31, 95% CI [-32.80, 10.18], t(2068) = -1.03, p = 0.302;
## Std. beta = -1.22, 95% CI [-3.52, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-10.48, 8.30], t(2068) = -0.23, p = 0.820; Std.
## beta = -0.12, 95% CI [-1.13, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-3.08, 4.47], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-10.59, 2.23], t(2068) = -1.28, p = 0.201; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.91, 10.31], t(2068) = 0.70, p = 0.487; Std.
## beta = 0.29, 95% CI [-0.53, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.16, 3.93], t(2068) = -0.26, p = 0.791; Std.
## beta = -0.07, 95% CI [-0.55, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.72, 95% CI [3.66, 19.78], t(2068) = 2.85, p = 0.004; Std.
## beta = 1.26, 95% CI [0.39, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.24, 8.80], t(2068) = 1.17, p = 0.244; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-7.82, 2.86], t(2068) = -0.91, p = 0.362; Std.
## beta = -0.27, 95% CI [-0.84, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-6.69, 0.46], t(2068) = -1.71, p = 0.088; Std.
## beta = -0.33, 95% CI [-0.72, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.97, 95% CI [-62.71, -29.23], t(2068) = -5.39, p < .001;
## Std. beta = -4.94, 95% CI [-6.74, -3.14])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-8.71, 8.65], t(2068) = -6.00e-03, p = 0.995;
## Std. beta = -2.81e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.92, 11.78], t(2068) = 0.17, p = 0.866; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.43, 11.72], t(2068) = 0.21, p = 0.832; Std.
## beta = 0.12, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SS_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to SS_5yrPreCensor = 0, is at 60.68 (95% CI [56.90, 64.47],
## t(2068) = 31.43, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.40, 95% CI [-5.73, -3.07], t(2068) = -6.48, p < .001; Std. beta = -0.44, 95%
## CI [-0.54, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -5.60, 95% CI [-19.17, 7.97], t(2068) = -0.81, p = 0.418; Std. beta =
## -0.04, 95% CI [-0.20, 0.12])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-40.44, 50.79], t(2068) = 0.22, p = 0.824; Std. beta = -1.31,
## 95% CI [-4.73, 2.11])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.05, 37.30], t(2068) = 1.13, p = 0.259; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-19.64, 26.50], t(2068) = 0.29, p = 0.771; Std. beta = -0.25,
## 95% CI [-1.77, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-30.77, 7.42], t(2068) = -1.20, p = 0.231; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.96, 95% CI [-3.50, 43.41], t(2068) = 1.67, p = 0.095; Std. beta = 0.90,
## 95% CI [-0.60, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.84, 95% CI [3.55, 22.14], t(2068) = 2.71, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.15, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.01, 95% CI [-0.42, 46.44], t(2068) = 1.93, p = 0.054; Std. beta = 0.76,
## 95% CI [-0.71, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.34, 95% CI [-2.99, 9.67], t(2068) = 1.03, p = 0.301; Std. beta = 0.13, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-2.13, 22.96], t(2068) = 1.63, p = 0.103; Std. beta = 0.40,
## 95% CI [-0.37, 1.16])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-5.95, 4.91], t(2068) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.20, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.37, 95% CI [-18.03, 7.28], t(2068) = -0.83, p = 0.405; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.71, 95% CI [-1.49, 10.91], t(2068) = 1.49, p = 0.137; Std. beta = 0.24, 95%
## CI [-0.14, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.52, 95% CI [-11.75, 4.71], t(2068) = -0.84, p = 0.402; Std. beta = -0.03,
## 95% CI [-0.53, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-28.17, 18.59], t(2068) = -0.40, p = 0.688; Std. beta = 0.39,
## 95% CI [-1.19, 1.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-19.53, 18.33], t(2068) = -0.06, p = 0.951; Std. beta = 0.57,
## 95% CI [-0.57, 1.70])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 19.52, 95% CI [-20.14, 59.19], t(2068) = 0.97, p = 0.334; Std. beta = 1.15,
## 95% CI [-1.19, 3.49])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-6.11e-03, 29.19], t(2068) = 1.96, p = 0.050; Std. beta =
## 1.12, 95% CI [0.20, 2.03])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.00, 95% CI [-12.19, 34.20], t(2068) = 0.93, p = 0.352; Std. beta = 0.63,
## 95% CI [-0.83, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.92, 95% CI [-1.46, 33.29], t(2068) = 1.80, p = 0.073; Std. beta = 0.77,
## 95% CI [-0.29, 1.84])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.98, 95% CI [-21.51, 37.47], t(2068) = 0.53, p = 0.596; Std. beta = 0.73,
## 95% CI [-1.89, 3.35])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.51, 95% CI [-60.58, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.28, 0.50])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-28.91, 0.94], t(2068) = -1.84, p = 0.066; Std. beta = -0.63,
## 95% CI [-1.57, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-27.57, 38.58], t(2068) = 0.33, p = 0.744; Std. beta = 0.32,
## 95% CI [-1.63, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-21.56, 25.99], t(2068) = 0.18, p = 0.855; Std. beta = 0.68,
## 95% CI [-1.45, 2.81])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-6.63, 23.21], t(2068) = 1.09, p = 0.276; Std. beta = 0.78, 95%
## CI [-0.25, 1.81])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.45, 16.89], t(2068) = 0.46, p = 0.645; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-27.92, 36.46], t(2068) = 0.26, p = 0.795; Std. beta = 0.64,
## 95% CI [-1.28, 2.56])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-8.34, 12.84], t(2068) = 0.42, p = 0.677; Std. beta = -0.21,
## 95% CI [-0.92, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -9.79, 95% CI [-24.85, 5.27], t(2068) = -1.28, p = 0.202; Std. beta = -0.48,
## 95% CI [-1.62, 0.67])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-6.90, 18.22], t(2068) = 0.88, p = 0.377; Std. beta = 0.34, 95%
## CI [-0.43, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 9.19, 95% CI [-13.47, 31.84], t(2068) = 0.80, p = 0.427; Std. beta = -0.18,
## 95% CI [-1.57, 1.21])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-18.64, 19.75], t(2068) = 0.06, p = 0.955; Std. beta = -0.98,
## 95% CI [-3.05, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.74, 95% CI [-34.84, 31.37], t(2068) = -0.10, p = 0.918; Std. beta = -0.20,
## 95% CI [-2.15, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.19, 95% CI [-10.41, 18.78], t(2068) = 0.56, p = 0.574; Std. beta = 0.31,
## 95% CI [-0.56, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-4.21, 28.74], t(2068) = 1.46, p = 0.145; Std. beta = 0.35,
## 95% CI [-0.68, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.03, 95% CI [-30.94, 2.89], t(2068) = -1.63, p = 0.104; Std. beta = -0.59,
## 95% CI [-1.71, 0.54])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.88, 15.14], t(2068) = 0.41, p = 0.680; Std. beta = 0.10, 95%
## CI [-0.67, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.22, 95% CI [-12.92, 25.35], t(2068) = 0.64, p = 0.524; Std. beta = 1.41,
## 95% CI [0.20, 2.62])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.60, 95% CI [-27.36, 2.17], t(2068) = -1.67, p = 0.094; Std. beta = -0.45,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.19, 95% CI [-3.15, 29.52], t(2068) = 1.58, p = 0.114; Std. beta = 0.56,
## 95% CI [-0.44, 1.55])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.54, 95% CI [1.47, 23.61], t(2068) = 2.22, p = 0.026; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.87, 95% CI [-14.89, 50.64], t(2068) = 1.07, p = 0.285; Std. beta = -3.04,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 29.69, 95% CI [6.44, 52.94], t(2068) = 2.50, p = 0.012; Std. beta = 1.75, 95%
## CI [0.26, 3.24])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 0.02, 95% CI [-19.09, 19.14], t(2068) = 2.38e-03, p = 0.998; Std. beta =
## 0.08, 95% CI [-1.24, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-10.06, 10.53], t(2068) = 0.04, p = 0.964; Std. beta = 0.12,
## 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.29, 95% CI [-3.80, 6.37], t(2068) =
## 0.50, p = 0.619; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -18.12, 95% CI [-49.33, 13.09], t(2068) = -1.14, p = 0.255;
## Std. beta = -1.95, 95% CI [-5.30, 1.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.22, 11.42], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.11, 95% CI [-15.90, 5.67], t(2068) = -0.93, p = 0.353; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-12.93, 11.41], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-12.42, 6.32], t(2068) = -0.64, p = 0.523; Std.
## beta = -0.33, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.97, 95% CI [-6.66, -1.27], t(2068) = -2.89, p = 0.004; Std.
## beta = -0.43, 95% CI [-0.72, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.68, 95% CI [-15.01, 1.65], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-2.88, 1.26], t(2068) = -0.76, p = 0.445; Std.
## beta = -0.09, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-6.56, 1.63], t(2068) = -1.18, p = 0.239; Std.
## beta = -0.26, 95% CI [-0.70, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-0.04, 3.71], t(2068) = 1.92, p = 0.055; Std.
## beta = 0.20, 95% CI [-4.50e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.34, 95% CI [-0.41, 13.09], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.68, 95% CI [-0.04, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.46, 1.66], t(2068) = -0.38, p = 0.704; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-1.11, 5.06], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.21, 95% CI [-0.12, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.53, 20.68], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.59, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.75, 95% CI [0.76, 12.74], t(2068) = 2.21, p = 0.027; Std.
## beta = 0.72, 95% CI [0.08, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-2.46, 8.20], t(2068) = 1.06, p = 0.291; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-8.23, 7.74], t(2068) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.88, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-9.73, 5.99], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-34.20, 39.99], t(2068) = 0.15, p = 0.878; Std.
## beta = 0.31, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.98, 95% CI [-25.25, 19.28], t(2068) = -0.26, p = 0.793;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-3.05, 7.32], t(2068) = 0.81, p = 0.419; Std.
## beta = 0.23, 95% CI [-0.33, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-14.93, 27.35], t(2068) = 0.58, p = 0.565; Std.
## beta = 0.67, 95% CI [-1.60, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.95, 11.43], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.35, 95% CI [-0.53, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.27, 7.07], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.10, 95% CI [-0.57, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.45, 13.12], t(2068) = 0.97, p = 0.333; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-9.27, 1.52], t(2068) = -1.41, p = 0.159; Std.
## beta = -0.42, 95% CI [-1.00, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-8.71, 10.97], t(2068) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.94, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.47, 4.56], t(2068) = 0.02, p = 0.983; Std.
## beta = 5.17e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -8.12, 95% CI [-16.39, 0.15], t(2068) = -1.93, p = 0.054; Std.
## beta = -0.87, 95% CI [-1.76, 0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.31, 95% CI [-32.80, 10.18], t(2068) = -1.03, p = 0.302;
## Std. beta = -1.22, 95% CI [-3.52, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-10.48, 8.30], t(2068) = -0.23, p = 0.820; Std.
## beta = -0.12, 95% CI [-1.13, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-3.08, 4.47], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-10.59, 2.23], t(2068) = -1.28, p = 0.201; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.91, 10.31], t(2068) = 0.70, p = 0.487; Std.
## beta = 0.29, 95% CI [-0.53, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.16, 3.93], t(2068) = -0.26, p = 0.791; Std.
## beta = -0.07, 95% CI [-0.55, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.72, 95% CI [3.66, 19.78], t(2068) = 2.85, p = 0.004; Std.
## beta = 1.26, 95% CI [0.39, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.24, 8.80], t(2068) = 1.17, p = 0.244; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-7.82, 2.86], t(2068) = -0.91, p = 0.362; Std.
## beta = -0.27, 95% CI [-0.84, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-6.69, 0.46], t(2068) = -1.71, p = 0.088; Std.
## beta = -0.33, 95% CI [-0.72, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.97, 95% CI [-62.71, -29.23], t(2068) = -5.39, p < .001;
## Std. beta = -4.94, 95% CI [-6.74, -3.14])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-8.71, 8.65], t(2068) = -6.00e-03, p = 0.995;
## Std. beta = -2.81e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.92, 11.78], t(2068) = 0.17, p = 0.866; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.43, 11.72], t(2068) = 0.21, p = 0.832; Std.
## beta = 0.12, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.21. The model's intercept, corresponding to site =
## Simmons, is at 60.68 (95% CI [56.90, 64.47], t(2068) = 31.43, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.40, 95% CI [-5.73, -3.07], t(2068) = -6.48, p < .001; Std. beta = -0.44, 95%
## CI [-0.54, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -5.60, 95% CI [-19.17, 7.97], t(2068) = -0.81, p = 0.418; Std. beta =
## -0.04, 95% CI [-0.20, 0.12])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-40.44, 50.79], t(2068) = 0.22, p = 0.824; Std. beta = -1.31,
## 95% CI [-4.73, 2.11])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.05, 37.30], t(2068) = 1.13, p = 0.259; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-19.64, 26.50], t(2068) = 0.29, p = 0.771; Std. beta = -0.25,
## 95% CI [-1.77, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-30.77, 7.42], t(2068) = -1.20, p = 0.231; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.96, 95% CI [-3.50, 43.41], t(2068) = 1.67, p = 0.095; Std. beta = 0.90,
## 95% CI [-0.60, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.84, 95% CI [3.55, 22.14], t(2068) = 2.71, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.15, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.01, 95% CI [-0.42, 46.44], t(2068) = 1.93, p = 0.054; Std. beta = 0.76,
## 95% CI [-0.71, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.34, 95% CI [-2.99, 9.67], t(2068) = 1.03, p = 0.301; Std. beta = 0.13, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-2.13, 22.96], t(2068) = 1.63, p = 0.103; Std. beta = 0.40,
## 95% CI [-0.37, 1.16])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-5.95, 4.91], t(2068) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.20, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.37, 95% CI [-18.03, 7.28], t(2068) = -0.83, p = 0.405; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.71, 95% CI [-1.49, 10.91], t(2068) = 1.49, p = 0.137; Std. beta = 0.24, 95%
## CI [-0.14, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.52, 95% CI [-11.75, 4.71], t(2068) = -0.84, p = 0.402; Std. beta = -0.03,
## 95% CI [-0.53, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-28.17, 18.59], t(2068) = -0.40, p = 0.688; Std. beta = 0.39,
## 95% CI [-1.19, 1.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-19.53, 18.33], t(2068) = -0.06, p = 0.951; Std. beta = 0.57,
## 95% CI [-0.57, 1.70])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 19.52, 95% CI [-20.14, 59.19], t(2068) = 0.97, p = 0.334; Std. beta = 1.15,
## 95% CI [-1.19, 3.49])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-6.11e-03, 29.19], t(2068) = 1.96, p = 0.050; Std. beta =
## 1.12, 95% CI [0.20, 2.03])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.00, 95% CI [-12.19, 34.20], t(2068) = 0.93, p = 0.352; Std. beta = 0.63,
## 95% CI [-0.83, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.92, 95% CI [-1.46, 33.29], t(2068) = 1.80, p = 0.073; Std. beta = 0.77,
## 95% CI [-0.29, 1.84])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.98, 95% CI [-21.51, 37.47], t(2068) = 0.53, p = 0.596; Std. beta = 0.73,
## 95% CI [-1.89, 3.35])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.51, 95% CI [-60.58, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.28, 0.50])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-28.91, 0.94], t(2068) = -1.84, p = 0.066; Std. beta = -0.63,
## 95% CI [-1.57, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-27.57, 38.58], t(2068) = 0.33, p = 0.744; Std. beta = 0.32,
## 95% CI [-1.63, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-21.56, 25.99], t(2068) = 0.18, p = 0.855; Std. beta = 0.68,
## 95% CI [-1.45, 2.81])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-6.63, 23.21], t(2068) = 1.09, p = 0.276; Std. beta = 0.78, 95%
## CI [-0.25, 1.81])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.45, 16.89], t(2068) = 0.46, p = 0.645; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-27.92, 36.46], t(2068) = 0.26, p = 0.795; Std. beta = 0.64,
## 95% CI [-1.28, 2.56])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-8.34, 12.84], t(2068) = 0.42, p = 0.677; Std. beta = -0.21,
## 95% CI [-0.92, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -9.79, 95% CI [-24.85, 5.27], t(2068) = -1.28, p = 0.202; Std. beta = -0.48,
## 95% CI [-1.62, 0.67])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-6.90, 18.22], t(2068) = 0.88, p = 0.377; Std. beta = 0.34, 95%
## CI [-0.43, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 9.19, 95% CI [-13.47, 31.84], t(2068) = 0.80, p = 0.427; Std. beta = -0.18,
## 95% CI [-1.57, 1.21])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-18.64, 19.75], t(2068) = 0.06, p = 0.955; Std. beta = -0.98,
## 95% CI [-3.05, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.74, 95% CI [-34.84, 31.37], t(2068) = -0.10, p = 0.918; Std. beta = -0.20,
## 95% CI [-2.15, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.19, 95% CI [-10.41, 18.78], t(2068) = 0.56, p = 0.574; Std. beta = 0.31,
## 95% CI [-0.56, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-4.21, 28.74], t(2068) = 1.46, p = 0.145; Std. beta = 0.35,
## 95% CI [-0.68, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.03, 95% CI [-30.94, 2.89], t(2068) = -1.63, p = 0.104; Std. beta = -0.59,
## 95% CI [-1.71, 0.54])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.88, 15.14], t(2068) = 0.41, p = 0.680; Std. beta = 0.10, 95%
## CI [-0.67, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.22, 95% CI [-12.92, 25.35], t(2068) = 0.64, p = 0.524; Std. beta = 1.41,
## 95% CI [0.20, 2.62])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.60, 95% CI [-27.36, 2.17], t(2068) = -1.67, p = 0.094; Std. beta = -0.45,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.19, 95% CI [-3.15, 29.52], t(2068) = 1.58, p = 0.114; Std. beta = 0.56,
## 95% CI [-0.44, 1.55])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.54, 95% CI [1.47, 23.61], t(2068) = 2.22, p = 0.026; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.87, 95% CI [-14.89, 50.64], t(2068) = 1.07, p = 0.285; Std. beta = -3.04,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 29.69, 95% CI [6.44, 52.94], t(2068) = 2.50, p = 0.012; Std. beta = 1.75, 95%
## CI [0.26, 3.24])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 0.02, 95% CI [-19.09, 19.14], t(2068) = 2.38e-03, p = 0.998; Std. beta =
## 0.08, 95% CI [-1.24, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-10.06, 10.53], t(2068) = 0.04, p = 0.964; Std. beta = 0.12,
## 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.29, 95% CI [-3.80, 6.37], t(2068) =
## 0.50, p = 0.619; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -18.12, 95% CI [-49.33, 13.09], t(2068) = -1.14, p = 0.255;
## Std. beta = -1.95, 95% CI [-5.30, 1.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.22, 11.42], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.11, 95% CI [-15.90, 5.67], t(2068) = -0.93, p = 0.353; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-12.93, 11.41], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-12.42, 6.32], t(2068) = -0.64, p = 0.523; Std.
## beta = -0.33, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.97, 95% CI [-6.66, -1.27], t(2068) = -2.89, p = 0.004; Std.
## beta = -0.43, 95% CI [-0.72, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.68, 95% CI [-15.01, 1.65], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-2.88, 1.26], t(2068) = -0.76, p = 0.445; Std.
## beta = -0.09, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-6.56, 1.63], t(2068) = -1.18, p = 0.239; Std.
## beta = -0.26, 95% CI [-0.70, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-0.04, 3.71], t(2068) = 1.92, p = 0.055; Std.
## beta = 0.20, 95% CI [-4.50e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.34, 95% CI [-0.41, 13.09], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.68, 95% CI [-0.04, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.46, 1.66], t(2068) = -0.38, p = 0.704; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-1.11, 5.06], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.21, 95% CI [-0.12, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.53, 20.68], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.59, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.75, 95% CI [0.76, 12.74], t(2068) = 2.21, p = 0.027; Std.
## beta = 0.72, 95% CI [0.08, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-2.46, 8.20], t(2068) = 1.06, p = 0.291; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-8.23, 7.74], t(2068) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.88, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-9.73, 5.99], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-34.20, 39.99], t(2068) = 0.15, p = 0.878; Std.
## beta = 0.31, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.98, 95% CI [-25.25, 19.28], t(2068) = -0.26, p = 0.793;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-3.05, 7.32], t(2068) = 0.81, p = 0.419; Std.
## beta = 0.23, 95% CI [-0.33, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-14.93, 27.35], t(2068) = 0.58, p = 0.565; Std.
## beta = 0.67, 95% CI [-1.60, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.95, 11.43], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.35, 95% CI [-0.53, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.27, 7.07], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.10, 95% CI [-0.57, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.45, 13.12], t(2068) = 0.97, p = 0.333; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-9.27, 1.52], t(2068) = -1.41, p = 0.159; Std.
## beta = -0.42, 95% CI [-1.00, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-8.71, 10.97], t(2068) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.94, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.47, 4.56], t(2068) = 0.02, p = 0.983; Std.
## beta = 5.17e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -8.12, 95% CI [-16.39, 0.15], t(2068) = -1.93, p = 0.054; Std.
## beta = -0.87, 95% CI [-1.76, 0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.31, 95% CI [-32.80, 10.18], t(2068) = -1.03, p = 0.302;
## Std. beta = -1.22, 95% CI [-3.52, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-10.48, 8.30], t(2068) = -0.23, p = 0.820; Std.
## beta = -0.12, 95% CI [-1.13, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-3.08, 4.47], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-10.59, 2.23], t(2068) = -1.28, p = 0.201; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.91, 10.31], t(2068) = 0.70, p = 0.487; Std.
## beta = 0.29, 95% CI [-0.53, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.16, 3.93], t(2068) = -0.26, p = 0.791; Std.
## beta = -0.07, 95% CI [-0.55, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.72, 95% CI [3.66, 19.78], t(2068) = 2.85, p = 0.004; Std.
## beta = 1.26, 95% CI [0.39, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.24, 8.80], t(2068) = 1.17, p = 0.244; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-7.82, 2.86], t(2068) = -0.91, p = 0.362; Std.
## beta = -0.27, 95% CI [-0.84, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-6.69, 0.46], t(2068) = -1.71, p = 0.088; Std.
## beta = -0.33, 95% CI [-0.72, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.97, 95% CI [-62.71, -29.23], t(2068) = -5.39, p < .001;
## Std. beta = -4.94, 95% CI [-6.74, -3.14])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-8.71, 8.65], t(2068) = -6.00e-03, p = 0.995;
## Std. beta = -2.81e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.92, 11.78], t(2068) = 0.17, p = 0.866; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.43, 11.72], t(2068) = 0.21, p = 0.832; Std.
## beta = 0.12, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to cohort = CARE-PF, is at 60.68 (95% CI [56.90, 64.47], t(2068)
## = 31.43, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.40, 95% CI [-5.73, -3.07], t(2068) = -6.48, p < .001; Std. beta = -0.44, 95%
## CI [-0.54, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -5.60, 95% CI [-19.17, 7.97], t(2068) = -0.81, p = 0.418; Std. beta =
## -0.04, 95% CI [-0.20, 0.12])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-40.44, 50.79], t(2068) = 0.22, p = 0.824; Std. beta = -1.31,
## 95% CI [-4.73, 2.11])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 13.62, 95% CI [-10.05, 37.30], t(2068) = 1.13, p = 0.259; Std. beta = 0.95,
## 95% CI [-0.47, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-19.64, 26.50], t(2068) = 0.29, p = 0.771; Std. beta = -0.25,
## 95% CI [-1.77, 1.26])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-30.77, 7.42], t(2068) = -1.20, p = 0.231; Std. beta = -0.76,
## 95% CI [-2.14, 0.63])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 19.96, 95% CI [-3.50, 43.41], t(2068) = 1.67, p = 0.095; Std. beta = 0.90,
## 95% CI [-0.60, 2.41])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.84, 95% CI [3.55, 22.14], t(2068) = 2.71, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.15, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 23.01, 95% CI [-0.42, 46.44], t(2068) = 1.93, p = 0.054; Std. beta = 0.76,
## 95% CI [-0.71, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.34, 95% CI [-2.99, 9.67], t(2068) = 1.03, p = 0.301; Std. beta = 0.13, 95%
## CI [-0.26, 0.51])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.42, 95% CI [-2.13, 22.96], t(2068) = 1.63, p = 0.103; Std. beta = 0.40,
## 95% CI [-0.37, 1.16])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.52, 95% CI [-5.95, 4.91], t(2068) = -0.19, p = 0.852; Std. beta = 0.13,
## 95% CI [-0.20, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.37, 95% CI [-18.03, 7.28], t(2068) = -0.83, p = 0.405; Std. beta = 0.25,
## 95% CI [-0.64, 1.13])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.71, 95% CI [-1.49, 10.91], t(2068) = 1.49, p = 0.137; Std. beta = 0.24, 95%
## CI [-0.14, 0.62])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.52, 95% CI [-11.75, 4.71], t(2068) = -0.84, p = 0.402; Std. beta = -0.03,
## 95% CI [-0.53, 0.47])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-28.17, 18.59], t(2068) = -0.40, p = 0.688; Std. beta = 0.39,
## 95% CI [-1.19, 1.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-19.53, 18.33], t(2068) = -0.06, p = 0.951; Std. beta = 0.57,
## 95% CI [-0.57, 1.70])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 19.52, 95% CI [-20.14, 59.19], t(2068) = 0.97, p = 0.334; Std. beta = 1.15,
## 95% CI [-1.19, 3.49])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-6.11e-03, 29.19], t(2068) = 1.96, p = 0.050; Std. beta =
## 1.12, 95% CI [0.20, 2.03])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 11.00, 95% CI [-12.19, 34.20], t(2068) = 0.93, p = 0.352; Std. beta = 0.63,
## 95% CI [-0.83, 2.09])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 15.92, 95% CI [-1.46, 33.29], t(2068) = 1.80, p = 0.073; Std. beta = 0.77,
## 95% CI [-0.29, 1.84])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.98, 95% CI [-21.51, 37.47], t(2068) = 0.53, p = 0.596; Std. beta = 0.73,
## 95% CI [-1.89, 3.35])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.51, 95% CI [-60.58, 5.55], t(2068) = -1.63, p = 0.103; Std. beta = -1.89,
## 95% CI [-4.28, 0.50])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-28.91, 0.94], t(2068) = -1.84, p = 0.066; Std. beta = -0.63,
## 95% CI [-1.57, 0.30])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-27.57, 38.58], t(2068) = 0.33, p = 0.744; Std. beta = 0.32,
## 95% CI [-1.63, 2.28])
## - The effect of site [18R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-21.56, 25.99], t(2068) = 0.18, p = 0.855; Std. beta = 0.68,
## 95% CI [-1.45, 2.81])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-6.63, 23.21], t(2068) = 1.09, p = 0.276; Std. beta = 0.78, 95%
## CI [-0.25, 1.81])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 3.22, 95% CI [-10.45, 16.89], t(2068) = 0.46, p = 0.645; Std. beta = 0.27,
## 95% CI [-0.62, 1.16])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-27.92, 36.46], t(2068) = 0.26, p = 0.795; Std. beta = 0.64,
## 95% CI [-1.28, 2.56])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-8.34, 12.84], t(2068) = 0.42, p = 0.677; Std. beta = -0.21,
## 95% CI [-0.92, 0.49])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -9.79, 95% CI [-24.85, 5.27], t(2068) = -1.28, p = 0.202; Std. beta = -0.48,
## 95% CI [-1.62, 0.67])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.66, 95% CI [-6.90, 18.22], t(2068) = 0.88, p = 0.377; Std. beta = 0.34, 95%
## CI [-0.43, 1.11])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 9.19, 95% CI [-13.47, 31.84], t(2068) = 0.80, p = 0.427; Std. beta = -0.18,
## 95% CI [-1.57, 1.21])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.56, 95% CI [-18.64, 19.75], t(2068) = 0.06, p = 0.955; Std. beta = -0.98,
## 95% CI [-3.05, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.74, 95% CI [-34.84, 31.37], t(2068) = -0.10, p = 0.918; Std. beta = -0.20,
## 95% CI [-2.15, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.19, 95% CI [-10.41, 18.78], t(2068) = 0.56, p = 0.574; Std. beta = 0.31,
## 95% CI [-0.56, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.26, 95% CI [-4.21, 28.74], t(2068) = 1.46, p = 0.145; Std. beta = 0.35,
## 95% CI [-0.68, 1.39])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -14.03, 95% CI [-30.94, 2.89], t(2068) = -1.63, p = 0.104; Std. beta = -0.59,
## 95% CI [-1.71, 0.54])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.88, 15.14], t(2068) = 0.41, p = 0.680; Std. beta = 0.10, 95%
## CI [-0.67, 0.87])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 6.22, 95% CI [-12.92, 25.35], t(2068) = 0.64, p = 0.524; Std. beta = 1.41,
## 95% CI [0.20, 2.62])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.60, 95% CI [-27.36, 2.17], t(2068) = -1.67, p = 0.094; Std. beta = -0.45,
## 95% CI [-1.39, 0.48])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.19, 95% CI [-3.15, 29.52], t(2068) = 1.58, p = 0.114; Std. beta = 0.56,
## 95% CI [-0.44, 1.55])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.54, 95% CI [1.47, 23.61], t(2068) = 2.22, p = 0.026; Std. beta = 0.46, 95%
## CI [-0.21, 1.14])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.87, 95% CI [-14.89, 50.64], t(2068) = 1.07, p = 0.285; Std. beta = -3.04,
## 95% CI [-5.21, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 29.69, 95% CI [6.44, 52.94], t(2068) = 2.50, p = 0.012; Std. beta = 1.75, 95%
## CI [0.26, 3.24])
## - The effect of site [41R] is statistically non-significant and positive (beta
## = 0.02, 95% CI [-19.09, 19.14], t(2068) = 2.38e-03, p = 0.998; Std. beta =
## 0.08, 95% CI [-1.24, 1.41])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-10.06, 10.53], t(2068) = 0.04, p = 0.964; Std. beta = 0.12,
## 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.29, 95% CI [-3.80, 6.37], t(2068) =
## 0.50, p = 0.619; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -18.12, 95% CI [-49.33, 13.09], t(2068) = -1.14, p = 0.255;
## Std. beta = -1.95, 95% CI [-5.30, 1.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-8.22, 11.42], t(2068) = 0.32, p = 0.750; Std.
## beta = 0.17, 95% CI [-0.88, 1.23])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.11, 95% CI [-15.90, 5.67], t(2068) = -0.93, p = 0.353; Std.
## beta = -0.55, 95% CI [-1.71, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-12.93, 11.41], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-12.42, 6.32], t(2068) = -0.64, p = 0.523; Std.
## beta = -0.33, 95% CI [-1.33, 0.68])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.97, 95% CI [-6.66, -1.27], t(2068) = -2.89, p = 0.004; Std.
## beta = -0.43, 95% CI [-0.72, -0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.68, 95% CI [-15.01, 1.65], t(2068) = -1.57, p = 0.116; Std.
## beta = -0.72, 95% CI [-1.61, 0.18])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.81, 95% CI [-2.88, 1.26], t(2068) = -0.76, p = 0.445; Std.
## beta = -0.09, 95% CI [-0.31, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-6.56, 1.63], t(2068) = -1.18, p = 0.239; Std.
## beta = -0.26, 95% CI [-0.70, 0.18])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-0.04, 3.71], t(2068) = 1.92, p = 0.055; Std.
## beta = 0.20, 95% CI [-4.50e-03, 0.40])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.34, 95% CI [-0.41, 13.09], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.68, 95% CI [-0.04, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.46, 1.66], t(2068) = -0.38, p = 0.704; Std.
## beta = -0.04, 95% CI [-0.26, 0.18])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-1.11, 5.06], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.21, 95% CI [-0.12, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.58, 95% CI [-5.53, 20.68], t(2068) = 1.13, p = 0.257; Std.
## beta = 0.81, 95% CI [-0.59, 2.22])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.75, 95% CI [0.76, 12.74], t(2068) = 2.21, p = 0.027; Std.
## beta = 0.72, 95% CI [0.08, 1.37])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-2.46, 8.20], t(2068) = 1.06, p = 0.291; Std.
## beta = 0.31, 95% CI [-0.26, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-8.23, 7.74], t(2068) = -0.06, p = 0.952; Std.
## beta = -0.03, 95% CI [-0.88, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.87, 95% CI [-9.73, 5.99], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.20, 95% CI [-1.05, 0.64])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-34.20, 39.99], t(2068) = 0.15, p = 0.878; Std.
## beta = 0.31, 95% CI [-3.67, 4.30])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.98, 95% CI [-25.25, 19.28], t(2068) = -0.26, p = 0.793;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-3.05, 7.32], t(2068) = 0.81, p = 0.419; Std.
## beta = 0.23, 95% CI [-0.33, 0.79])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-14.93, 27.35], t(2068) = 0.58, p = 0.565; Std.
## beta = 0.67, 95% CI [-1.60, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.95, 11.43], t(2068) = 0.78, p = 0.438; Std.
## beta = 0.35, 95% CI [-0.53, 1.23])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.27, 7.07], t(2068) = 0.29, p = 0.775; Std.
## beta = 0.10, 95% CI [-0.57, 0.76])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.45, 13.12], t(2068) = 0.97, p = 0.333; Std.
## beta = 0.47, 95% CI [-0.48, 1.41])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.87, 95% CI [-9.27, 1.52], t(2068) = -1.41, p = 0.159; Std.
## beta = -0.42, 95% CI [-1.00, 0.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-8.71, 10.97], t(2068) = 0.22, p = 0.822; Std.
## beta = 0.12, 95% CI [-0.94, 1.18])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-4.47, 4.56], t(2068) = 0.02, p = 0.983; Std.
## beta = 5.17e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -8.12, 95% CI [-16.39, 0.15], t(2068) = -1.93, p = 0.054; Std.
## beta = -0.87, 95% CI [-1.76, 0.02])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.31, 95% CI [-32.80, 10.18], t(2068) = -1.03, p = 0.302;
## Std. beta = -1.22, 95% CI [-3.52, 1.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-10.48, 8.30], t(2068) = -0.23, p = 0.820; Std.
## beta = -0.12, 95% CI [-1.13, 0.89])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.69, 95% CI [-3.08, 4.47], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.07, 95% CI [-0.33, 0.48])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-10.59, 2.23], t(2068) = -1.28, p = 0.201; Std.
## beta = -0.45, 95% CI [-1.14, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.91, 10.31], t(2068) = 0.70, p = 0.487; Std.
## beta = 0.29, 95% CI [-0.53, 1.11])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-5.16, 3.93], t(2068) = -0.26, p = 0.791; Std.
## beta = -0.07, 95% CI [-0.55, 0.42])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.72, 95% CI [3.66, 19.78], t(2068) = 2.85, p = 0.004; Std.
## beta = 1.26, 95% CI [0.39, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.28, 95% CI [-2.24, 8.80], t(2068) = 1.17, p = 0.244; Std.
## beta = 0.35, 95% CI [-0.24, 0.95])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.48, 95% CI [-7.82, 2.86], t(2068) = -0.91, p = 0.362; Std.
## beta = -0.27, 95% CI [-0.84, 0.31])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-6.69, 0.46], t(2068) = -1.71, p = 0.088; Std.
## beta = -0.33, 95% CI [-0.72, 0.05])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -45.97, 95% CI [-62.71, -29.23], t(2068) = -5.39, p < .001;
## Std. beta = -4.94, 95% CI [-6.74, -3.14])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.03, 95% CI [-8.71, 8.65], t(2068) = -6.00e-03, p = 0.995;
## Std. beta = -2.81e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.92, 11.78], t(2068) = 0.17, p = 0.866; Std.
## beta = 0.10, 95% CI [-1.07, 1.27])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.43, 11.72], t(2068) = 0.21, p = 0.832; Std.
## beta = 0.12, 95% CI [-1.01, 1.26])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*SS_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14367.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2894 -0.4405 -0.0117 0.4488 4.5169
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 233.31 15.274
## time_firstPFT 13.53 3.678 -0.07
## Residual 25.63 5.062
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 32.86407 6.15177 5.342
## time_firstPFT -1.48730 2.24340 -0.663
## SS_5yrPreCensor -4.32870 6.74994 -0.641
## disadv 3.87537 2.89260 1.340
## dich_RaceNon-White -7.26575 2.79874 -2.596
## sexF 3.82212 1.74559 2.190
## age_dx 0.38762 0.09116 4.252
## smokeHxFormer 3.71215 1.73393 2.141
## smokeHxAlways 18.17845 8.43119 2.156
## smokeHxUnknown -2.39211 3.93691 -0.608
## site02R -1.30155 22.45651 -0.058
## site03R 11.74413 11.71364 1.003
## site04R 3.03676 11.27436 0.269
## site05R -13.01146 9.37164 -1.388
## site06R 10.36074 16.16433 0.641
## site07R 11.61598 4.58974 2.531
## site09R 21.32821 11.49039 1.856
## site101 4.30656 3.15337 1.366
## site102 11.77793 6.21776 1.894
## site103 -1.10208 2.81755 -0.391
## site104 -7.10353 6.23117 -1.140
## site105 4.48717 3.08723 1.453
## site106 -5.42975 4.12788 -1.315
## site107 -2.17918 11.47018 -0.190
## site108 4.16698 9.66792 0.431
## site10R 14.83972 19.89272 0.746
## site11R 10.86119 7.16554 1.516
## site12R 6.60618 11.34165 0.582
## site13R 17.29013 8.58195 2.015
## site14R 6.57571 14.68540 0.448
## site15R -34.09620 16.22432 -2.102
## site16R -8.28060 7.40951 -1.118
## site17R 9.70668 16.33240 0.594
## site18R -2.04320 11.70078 -0.175
## site19R 7.79576 7.34927 1.061
## site20R 1.79584 6.70922 0.268
## site21R 2.75978 15.69432 0.176
## site22R -1.94694 5.28243 -0.369
## site23R -12.79491 8.86806 -1.443
## site24R 4.44660 6.15559 0.722
## site25R 6.38372 11.23140 0.568
## site28R 3.95265 9.45296 0.418
## site29R -4.85170 16.21892 -0.299
## site31R 5.29327 7.21010 0.734
## site32R 9.43130 8.10677 1.163
## site33R -12.90610 8.32876 -1.550
## site34R 0.02932 6.12935 0.005
## site35R -0.43267 9.40387 -0.046
## site36R -11.57112 7.25236 -1.595
## site37R 15.69386 8.09326 1.939
## site38R 12.30161 5.42539 2.267
## site39R 23.03452 16.29186 1.414
## site40R 26.53631 11.40138 2.327
## site41R -2.55728 9.41818 -0.272
## site42R -0.61453 5.12045 -0.120
## time_firstPFT:SS_5yrPreCensor 1.23157 2.66630 0.462
## time_firstPFT:disadv 0.02685 1.10320 0.024
## time_firstPFT:dich_RaceNon-White 0.04722 1.11979 0.042
## time_firstPFT:sexF 0.01406 0.66002 0.021
## time_firstPFT:age_dx -0.06067 0.03462 -1.752
## time_firstPFT:smokeHxFormer 0.52786 0.67443 0.783
## time_firstPFT:smokeHxAlways 1.46547 5.30024 0.276
## time_firstPFT:smokeHxUnknown 1.56267 1.68438 0.928
## time_firstPFT:site02R -17.18214 16.02854 -1.072
## time_firstPFT:site03R 2.95534 5.09030 0.581
## time_firstPFT:site04R -4.71257 5.58603 -0.844
## time_firstPFT:site05R -0.43277 6.25115 -0.069
## time_firstPFT:site07R -3.42383 1.44503 -2.369
## time_firstPFT:site09R -6.44881 4.34833 -1.483
## time_firstPFT:site101 -0.62076 1.09596 -0.566
## time_firstPFT:site102 -2.52991 2.15149 -1.176
## time_firstPFT:site103 2.05356 1.02111 2.011
## time_firstPFT:site104 6.82645 3.53456 1.931
## time_firstPFT:site105 -0.32885 1.08556 -0.303
## time_firstPFT:site106 2.62865 1.64268 1.600
## time_firstPFT:site107 7.71729 6.72729 1.147
## time_firstPFT:site108 6.78627 3.31152 2.049
## time_firstPFT:site11R 3.78820 2.81251 1.347
## time_firstPFT:site12R 0.18508 4.16710 0.044
## time_firstPFT:site13R -1.31101 4.08950 -0.321
## time_firstPFT:site14R 3.38157 18.95635 0.178
## time_firstPFT:site15R -2.72717 11.40261 -0.239
## time_firstPFT:site16R 1.89627 2.74499 0.691
## time_firstPFT:site18R 6.75372 10.82653 0.624
## time_firstPFT:site19R 4.60491 4.28310 1.075
## time_firstPFT:site20R 1.72927 3.22402 0.536
## time_firstPFT:site21R 4.51548 4.55857 0.991
## time_firstPFT:site22R -2.90531 2.83726 -1.024
## time_firstPFT:site23R 8.95743 24.71785 0.362
## time_firstPFT:site24R 0.14057 2.34295 0.060
## time_firstPFT:site25R -7.22122 4.33437 -1.666
## time_firstPFT:site28R -9.76995 11.07785 -0.882
## time_firstPFT:site29R -0.37879 4.90779 -0.077
## time_firstPFT:site31R 0.86807 2.00871 0.432
## time_firstPFT:site32R -3.44111 3.34523 -1.029
## time_firstPFT:site33R 3.30294 4.00625 0.824
## time_firstPFT:site34R -0.38632 2.38524 -0.162
## time_firstPFT:site35R 12.65785 4.20406 3.011
## time_firstPFT:site36R 3.61376 2.87790 1.256
## time_firstPFT:site37R -1.69033 2.85260 -0.593
## time_firstPFT:site38R -2.84707 1.86620 -1.526
## time_firstPFT:site39R -46.42804 8.67006 -5.355
## time_firstPFT:site40R 1.08233 4.55630 0.238
## time_firstPFT:site41R 1.79311 5.58364 0.321
## time_firstPFT:site42R 2.12156 5.41506 0.392##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.921
## Unadjusted ICC: 0.694report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## SS_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 32.86 (95% CI [20.80, 44.93], t(2038)
## = 5.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## SS_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to
## SS_5yrPreCensor = 0, is at 32.86 (95% CI [20.80, 44.93], t(2038) = 5.34, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to disadv = 0, is at 32.86 (95% CI [20.80,
## 44.93], t(2038) = 5.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to dich_Race =
## White, is at 32.86 (95% CI [20.80, 44.93], t(2038) = 5.34, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 32.86 (95% CI [20.80,
## 44.93], t(2038) = 5.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to age_dx = 0, is at 32.86 (95% CI [20.80,
## 44.93], t(2038) = 5.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to smokeHx = Never, is at 32.86 (95% CI
## [20.80, 44.93], t(2038) = 5.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 32.86 (95% CI [20.80,
## 44.93], t(2038) = 5.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to cohort =
## CARE-PF, is at 32.86 (95% CI [20.80, 44.93], t(2038) = 5.34, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.49, 95% CI [-5.89, 2.91], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.51, 95% CI [-0.68, -0.35])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -4.33, 95% CI [-17.57, 8.91], t(2038) = -0.64, p = 0.521; Std. beta =
## -0.03, 95% CI [-0.19, 0.13])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.88, 95% CI [-1.80, 9.55], t(2038) = 1.34, p = 0.180; Std. beta = 0.07, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.27, 95% CI [-12.75, -1.78], t(2038) = -2.60, p = 0.009; Std. beta =
## -0.42, 95% CI [-0.78, -0.07])
## - The effect of sex [F] is statistically significant and positive (beta = 3.82,
## 95% CI [0.40, 7.25], t(2038) = 2.19, p = 0.029; Std. beta = 0.23, 95% CI
## [9.30e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.39,
## 95% CI [0.21, 0.57], t(2038) = 4.25, p < .001; Std. beta = 0.16, 95% CI [0.06,
## 0.27])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.71, 95% CI [0.31, 7.11], t(2038) = 2.14, p = 0.032; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.18, 95% CI [1.64, 34.71], t(2038) = 2.16, p = 0.031; Std. beta =
## 1.20, 95% CI [-7.19e-03, 2.41])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.39, 95% CI [-10.11, 5.33], t(2038) = -0.61, p = 0.544; Std. beta =
## -1.20e-03, 95% CI [-0.51, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-45.34, 42.74], t(2038) = -0.06, p = 0.954; Std. beta = -1.61,
## 95% CI [-5.01, 1.78])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 11.74, 95% CI [-11.23, 34.72], t(2038) = 1.00, p = 0.316; Std. beta = 0.96,
## 95% CI [-0.44, 2.36])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 3.04, 95% CI [-19.07, 25.15], t(2038) = 0.27, p = 0.788; Std. beta = -0.24,
## 95% CI [-1.73, 1.25])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.01, 95% CI [-31.39, 5.37], t(2038) = -1.39, p = 0.165; Std. beta = -0.81,
## 95% CI [-2.17, 0.56])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 10.36, 95% CI [-21.34, 42.06], t(2038) = 0.64, p = 0.522; Std. beta = 0.61,
## 95% CI [-1.26, 2.48])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.62, 95% CI [2.61, 20.62], t(2038) = 2.53, p = 0.011; Std. beta = 0.38, 95%
## CI [-0.17, 0.93])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.33, 95% CI [-1.21, 43.86], t(2038) = 1.86, p = 0.064; Std. beta = 0.68,
## 95% CI [-0.77, 2.13])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.31, 95% CI [-1.88, 10.49], t(2038) = 1.37, p = 0.172; Std. beta = 0.20, 95%
## CI [-0.19, 0.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.42, 23.97], t(2038) = 1.89, p = 0.058; Std. beta = 0.47,
## 95% CI [-0.29, 1.22])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-6.63, 4.42], t(2038) = -0.39, p = 0.696; Std. beta = 0.12,
## 95% CI [-0.23, 0.47])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.10, 95% CI [-19.32, 5.12], t(2038) = -1.14, p = 0.254; Std. beta = 0.19,
## 95% CI [-0.69, 1.07])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.49, 95% CI [-1.57, 10.54], t(2038) = 1.45, p = 0.146; Std. beta = 0.24, 95%
## CI [-0.14, 0.61])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.43, 95% CI [-13.53, 2.67], t(2038) = -1.32, p = 0.189; Std. beta = -0.08,
## 95% CI [-0.59, 0.42])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -2.18, 95% CI [-24.67, 20.32], t(2038) = -0.19, p = 0.849; Std. beta = 0.56,
## 95% CI [-1.00, 2.12])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 4.17, 95% CI [-14.79, 23.13], t(2038) = 0.43, p = 0.667; Std. beta = 0.85,
## 95% CI [-0.31, 2.02])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 14.84, 95% CI [-24.17, 53.85], t(2038) = 0.75, p = 0.456; Std. beta = 0.88,
## 95% CI [-1.43, 3.18])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-3.19, 24.91], t(2038) = 1.52, p = 0.130; Std. beta = 0.98,
## 95% CI [0.08, 1.88])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-15.64, 28.85], t(2038) = 0.58, p = 0.560; Std. beta = 0.41,
## 95% CI [-1.03, 1.84])
## - The effect of site [13R] is statistically significant and positive (beta =
## 17.29, 95% CI [0.46, 34.12], t(2038) = 2.01, p = 0.044; Std. beta = 0.90, 95%
## CI [-0.15, 1.96])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 6.58, 95% CI [-22.22, 35.38], t(2038) = 0.45, p = 0.654; Std. beta = 0.69,
## 95% CI [-1.92, 3.31])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.10, 95% CI [-65.91, -2.28], t(2038) = -2.10, p = 0.036; Std. beta = -2.26,
## 95% CI [-4.61, 0.10])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.28, 95% CI [-22.81, 6.25], t(2038) = -1.12, p = 0.264; Std. beta = -0.32,
## 95% CI [-1.25, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 9.71, 95% CI [-22.32, 41.74], t(2038) = 0.59, p = 0.552; Std. beta = 0.57,
## 95% CI [-1.32, 2.46])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-24.99, 20.90], t(2038) = -0.17, p = 0.861; Std. beta = 0.48,
## 95% CI [-1.64, 2.60])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 7.80, 95% CI [-6.62, 22.21], t(2038) = 1.06, p = 0.289; Std. beta = 0.87, 95%
## CI [-0.16, 1.90])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-11.36, 14.95], t(2038) = 0.27, p = 0.789; Std. beta = 0.26,
## 95% CI [-0.61, 1.14])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-28.02, 33.54], t(2038) = 0.18, p = 0.860; Std. beta = 0.57,
## 95% CI [-1.30, 2.43])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.95, 95% CI [-12.31, 8.41], t(2038) = -0.37, p = 0.712; Std. beta = -0.37,
## 95% CI [-1.08, 0.33])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -12.79, 95% CI [-30.19, 4.60], t(2038) = -1.44, p = 0.149; Std. beta = 0.05,
## 95% CI [-4.01, 4.11])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.45, 95% CI [-7.63, 16.52], t(2038) = 0.72, p = 0.470; Std. beta = 0.27, 95%
## CI [-0.48, 1.03])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 6.38, 95% CI [-15.64, 28.41], t(2038) = 0.57, p = 0.570; Std. beta = -0.27,
## 95% CI [-1.65, 1.11])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.95, 95% CI [-14.59, 22.49], t(2038) = 0.42, p = 0.676; Std. beta = -0.64,
## 95% CI [-2.73, 1.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.85, 95% CI [-36.66, 26.96], t(2038) = -0.30, p = 0.765; Std. beta = -0.32,
## 95% CI [-2.22, 1.58])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 5.29, 95% CI [-8.85, 19.43], t(2038) = 0.73, p = 0.463; Std. beta = 0.39, 95%
## CI [-0.47, 1.25])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 9.43, 95% CI [-6.47, 25.33], t(2038) = 1.16, p = 0.245; Std. beta = 0.25, 95%
## CI [-0.77, 1.27])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.91, 95% CI [-29.24, 3.43], t(2038) = -1.55, p = 0.121; Std. beta = -0.47,
## 95% CI [-1.58, 0.65])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-11.99, 12.05], t(2038) = 4.78e-03, p = 0.996; Std. beta =
## -0.03, 95% CI [-0.79, 0.73])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-18.87, 18.01], t(2038) = -0.05, p = 0.963; Std. beta = 1.11,
## 95% CI [-0.08, 2.30])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.57, 95% CI [-25.79, 2.65], t(2038) = -1.60, p = 0.111; Std. beta = -0.36,
## 95% CI [-1.28, 0.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 15.69, 95% CI [-0.18, 31.57], t(2038) = 1.94, p = 0.053; Std. beta = 0.77,
## 95% CI [-0.21, 1.76])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.30, 95% CI [1.66, 22.94], t(2038) = 2.27, p = 0.023; Std. beta = 0.47, 95%
## CI [-0.19, 1.13])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.03, 95% CI [-8.92, 54.98], t(2038) = 1.41, p = 0.158; Std. beta = -2.80,
## 95% CI [-4.95, -0.65])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.54, 95% CI [4.18, 48.90], t(2038) = 2.33, p = 0.020; Std. beta = 1.66, 95%
## CI [0.20, 3.13])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-21.03, 15.91], t(2038) = -0.27, p = 0.786; Std. beta =
## 9.69e-03, 95% CI [-1.30, 1.32])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-10.66, 9.43], t(2038) = -0.12, p = 0.904; Std. beta = 0.15,
## 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 1.23, 95% CI [-4.00, 6.46], t(2038) =
## 0.46, p = 0.644; Std. beta = 0.03, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.03, 95% CI [-2.14, 2.19], t(2038) = 0.02, p = 0.981; Std.
## beta = 8.22e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.05, 95% CI [-2.15, 2.24], t(2038) =
## 0.04, p = 0.966; Std. beta = 5.08e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.983; Std.
## beta = 1.52e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 7.23e-03], t(2038) = -1.75, p = 0.080;
## Std. beta = -0.06, 95% CI [-0.13, 7.17e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.53, 95% CI [-0.79, 1.85], t(2038) =
## 0.78, p = 0.434; Std. beta = 0.06, 95% CI [-0.09, 0.20])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.47, 95% CI [-8.93, 11.86], t(2038) =
## 0.28, p = 0.782; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.56, 95% CI [-1.74, 4.87], t(2038) =
## 0.93, p = 0.354; Std. beta = 0.17, 95% CI [-0.19, 0.52])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -17.18, 95% CI [-48.62, 14.25], t(2038) = -1.07, p = 0.284;
## Std. beta = -1.85, 95% CI [-5.24, 1.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.96, 95% CI [-7.03, 12.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.32, 95% CI [-0.76, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-15.67, 6.24], t(2038) = -0.84, p = 0.399; Std.
## beta = -0.51, 95% CI [-1.69, 0.67])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-12.69, 11.83], t(2038) = -0.07, p = 0.945;
## Std. beta = -0.05, 95% CI [-1.37, 1.27])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.42, 95% CI [-6.26, -0.59], t(2038) = -2.37, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.45, 95% CI [-14.98, 2.08], t(2038) = -1.48, p = 0.138; Std.
## beta = -0.69, 95% CI [-1.61, 0.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.62, 95% CI [-2.77, 1.53], t(2038) = -0.57, p = 0.571; Std.
## beta = -0.07, 95% CI [-0.30, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-6.75, 1.69], t(2038) = -1.18, p = 0.240; Std.
## beta = -0.27, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.05, 95% CI [0.05, 4.06], t(2038) = 2.01, p = 0.044; Std.
## beta = 0.22, 95% CI [5.49e-03, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.83, 95% CI [-0.11, 13.76], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.74, 95% CI [-0.01, 1.48])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-2.46, 1.80], t(2038) = -0.30, p = 0.762; Std.
## beta = -0.04, 95% CI [-0.26, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-0.59, 5.85], t(2038) = 1.60, p = 0.110; Std.
## beta = 0.28, 95% CI [-0.06, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.72, 95% CI [-5.48, 20.91], t(2038) = 1.15, p = 0.251; Std.
## beta = 0.83, 95% CI [-0.59, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.79, 95% CI [0.29, 13.28], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-1.73, 9.30], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.41, 95% CI [-0.19, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.99, 8.36], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.31, 95% CI [-9.33, 6.71], t(2038) = -0.32, p = 0.749; Std.
## beta = -0.14, 95% CI [-1.00, 0.72])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-33.79, 40.56], t(2038) = 0.18, p = 0.858; Std.
## beta = 0.36, 95% CI [-3.64, 4.37])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.73, 95% CI [-25.09, 19.63], t(2038) = -0.24, p = 0.811;
## Std. beta = -0.29, 95% CI [-2.70, 2.11])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-3.49, 7.28], t(2038) = 0.69, p = 0.490; Std.
## beta = 0.20, 95% CI [-0.38, 0.78])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.75, 95% CI [-14.48, 27.99], t(2038) = 0.62, p = 0.533; Std.
## beta = 0.73, 95% CI [-1.56, 3.01])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-3.79, 13.00], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.50, 95% CI [-0.41, 1.40])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.73, 95% CI [-4.59, 8.05], t(2038) = 0.54, p = 0.592; Std.
## beta = 0.19, 95% CI [-0.49, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.52, 95% CI [-4.42, 13.46], t(2038) = 0.99, p = 0.322; Std.
## beta = 0.49, 95% CI [-0.48, 1.45])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-8.47, 2.66], t(2038) = -1.02, p = 0.306; Std.
## beta = -0.31, 95% CI [-0.91, 0.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 8.96, 95% CI [-39.52, 57.43], t(2038) = 0.36, p = 0.717; Std.
## beta = 0.96, 95% CI [-4.26, 6.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-4.45, 4.74], t(2038) = 0.06, p = 0.952; Std.
## beta = 0.02, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -7.22, 95% CI [-15.72, 1.28], t(2038) = -1.67, p = 0.096; Std.
## beta = -0.78, 95% CI [-1.69, 0.14])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.77, 95% CI [-31.50, 11.96], t(2038) = -0.88, p = 0.378;
## Std. beta = -1.05, 95% CI [-3.39, 1.29])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.38, 95% CI [-10.00, 9.25], t(2038) = -0.08, p = 0.938; Std.
## beta = -0.04, 95% CI [-1.08, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-3.07, 4.81], t(2038) = 0.43, p = 0.666; Std.
## beta = 0.09, 95% CI [-0.33, 0.52])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-10.00, 3.12], t(2038) = -1.03, p = 0.304; Std.
## beta = -0.37, 95% CI [-1.08, 0.34])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-4.55, 11.16], t(2038) = 0.82, p = 0.410; Std.
## beta = 0.36, 95% CI [-0.49, 1.20])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-5.06, 4.29], t(2038) = -0.16, p = 0.871; Std.
## beta = -0.04, 95% CI [-0.55, 0.46])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.66, 95% CI [4.41, 20.90], t(2038) = 3.01, p = 0.003; Std.
## beta = 1.36, 95% CI [0.48, 2.25])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.61, 95% CI [-2.03, 9.26], t(2038) = 1.26, p = 0.209; Std.
## beta = 0.39, 95% CI [-0.22, 1.00])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-7.28, 3.90], t(2038) = -0.59, p = 0.554; Std.
## beta = -0.18, 95% CI [-0.78, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-6.51, 0.81], t(2038) = -1.53, p = 0.127; Std.
## beta = -0.31, 95% CI [-0.70, 0.09])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.43, 95% CI [-63.43, -29.42], t(2038) = -5.35, p < .001;
## Std. beta = -5.00, 95% CI [-6.83, -3.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-7.85, 10.02], t(2038) = 0.24, p = 0.812; Std.
## beta = 0.12, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-9.16, 12.74], t(2038) = 0.32, p = 0.748; Std.
## beta = 0.19, 95% CI [-0.99, 1.37])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.12, 95% CI [-8.50, 12.74], t(2038) = 0.39, p = 0.695; Std.
## beta = 0.23, 95% CI [-0.92, 1.37])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer1 <- lmer(fvc_pct ~ 1 + time_firstPFT*Soil_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(FVC_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14559.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.3226 -0.4426 -0.0144 0.4491 4.5338
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 256.69 16.021
## time_firstPFT 12.96 3.600 -0.11
## Residual 25.58 5.058
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 56.985632 2.863707 19.899
## time_firstPFT -4.499482 1.095454 -4.107
## Soil_5yrPreCensor 5.242288 5.265462 0.996
## site02R -7.642164 16.822662 -0.454
## site03R 10.888791 12.380893 0.879
## site04R 2.886196 11.759816 0.245
## site05R -10.766638 9.722642 -1.107
## site06R 18.899771 12.010659 1.574
## site07R 12.697373 4.732210 2.683
## site09R 22.703045 11.870759 1.913
## site101 3.784043 3.273015 1.156
## site102 11.781561 6.375372 1.848
## site103 0.399228 3.019379 0.132
## site104 -3.895060 6.631869 -0.587
## site105 5.499773 3.285701 1.674
## site106 -3.895208 4.180226 -0.932
## site107 -3.691295 11.971935 -0.308
## site108 1.110596 9.609035 0.116
## site10R 13.080703 17.469799 0.749
## site11R 12.609007 7.593268 1.661
## site12R 12.019616 11.798515 1.019
## site13R 16.746042 8.887138 1.884
## site14R 8.287114 15.038768 0.551
## site15R -27.753554 16.849780 -1.647
## site16R -14.581506 7.506314 -1.943
## site17R 4.871862 16.880657 0.289
## site18R -1.792236 12.165929 -0.147
## site19R 4.588236 8.550953 0.537
## site20R 2.771722 6.999719 0.396
## site21R 2.754060 16.455871 0.167
## site22R 2.212695 5.347782 0.414
## site23R -14.077046 8.380740 -1.680
## site24R 6.499907 6.395028 1.016
## site25R 2.015880 6.947329 0.290
## site28R 0.508179 9.783757 0.052
## site29R -2.437807 16.736545 -0.146
## site31R 4.965782 7.481534 0.664
## site32R 4.810911 11.135093 0.432
## site33R -19.901909 9.370298 -2.124
## site34R 3.305953 6.425036 0.515
## site35R 7.135933 9.807964 0.728
## site36R -12.823873 7.530658 -1.703
## site37R 13.487831 8.335914 1.618
## site38R 12.979232 5.659542 2.293
## site39R 18.241848 16.672977 1.094
## site40R 26.828038 11.903446 2.254
## site41R -0.742995 9.686542 -0.077
## site42R 0.398021 5.251044 0.076
## time_firstPFT:Soil_5yrPreCensor 0.699446 2.027348 0.345
## time_firstPFT:site02R -15.084338 14.716035 -1.025
## time_firstPFT:site03R 1.071016 5.155759 0.208
## time_firstPFT:site04R -5.067442 5.501361 -0.921
## time_firstPFT:site05R -0.771886 6.208061 -0.124
## time_firstPFT:site06R -3.262432 4.809137 -0.678
## time_firstPFT:site07R -3.936174 1.372105 -2.869
## time_firstPFT:site09R -6.373890 4.217939 -1.511
## time_firstPFT:site101 -0.677332 1.068712 -0.634
## time_firstPFT:site102 -2.495812 2.089114 -1.195
## time_firstPFT:site103 2.093902 1.057924 1.979
## time_firstPFT:site104 6.547041 3.470153 1.887
## time_firstPFT:site105 -0.232327 1.102876 -0.211
## time_firstPFT:site106 2.043804 1.566074 1.305
## time_firstPFT:site107 7.768139 6.697050 1.160
## time_firstPFT:site108 6.672409 3.049118 2.188
## time_firstPFT:site11R 2.788387 2.773566 1.005
## time_firstPFT:site12R -0.260486 4.072884 -0.064
## time_firstPFT:site13R -1.701916 4.028685 -0.422
## time_firstPFT:site14R 3.324525 18.919001 0.176
## time_firstPFT:site15R -2.954930 11.351746 -0.260
## time_firstPFT:site16R 2.427026 2.618883 0.927
## time_firstPFT:site18R 6.155147 10.814708 0.569
## time_firstPFT:site19R 2.565925 4.567457 0.562
## time_firstPFT:site20R 0.773098 3.146537 0.246
## time_firstPFT:site21R 4.226392 4.505952 0.938
## time_firstPFT:site22R -3.391919 2.674683 -1.268
## time_firstPFT:site23R 0.935802 5.173339 0.181
## time_firstPFT:site24R 0.009854 2.300705 0.004
## time_firstPFT:site25R -6.379969 2.705029 -2.359
## time_firstPFT:site28R -11.180132 10.958709 -1.020
## time_firstPFT:site29R -0.428786 4.718147 -0.091
## time_firstPFT:site31R 0.822122 1.954294 0.421
## time_firstPFT:site32R -5.286457 4.599010 -1.149
## time_firstPFT:site33R 2.657054 4.018728 0.661
## time_firstPFT:site34R -0.474054 2.330360 -0.203
## time_firstPFT:site35R 11.795133 4.118204 2.864
## time_firstPFT:site36R 3.229825 2.817081 1.147
## time_firstPFT:site37R -2.326107 2.719958 -0.855
## time_firstPFT:site38R -3.021431 1.828852 -1.652
## time_firstPFT:site39R -46.183637 8.531712 -5.413
## time_firstPFT:site40R -0.061411 4.436152 -0.014
## time_firstPFT:site41R 1.154377 5.511693 0.209
## time_firstPFT:site42R 1.317335 5.387230 0.245##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(FVC_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.924
## Unadjusted ICC: 0.727report(FVC_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## Soil_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.94) and the part
## related to the fixed effects alone (marginal R2) is of 0.21. The model's
## intercept, corresponding to time_firstPFT = 0, is at 56.99 (95% CI [51.37,
## 62.60], t(2068) = 19.90, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.50, 95% CI [-6.65, -2.35], t(2068) = -4.11, p < .001; Std. beta = -0.45, 95%
## CI [-0.55, -0.35])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.24, 95% CI [-5.08, 15.57], t(2068) = 1.00, p = 0.320; Std. beta =
## 0.09, 95% CI [-0.07, 0.25])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-40.63, 25.35], t(2068) = -0.45, p = 0.650; Std. beta = -1.80,
## 95% CI [-4.60, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.89, 95% CI [-13.39, 35.17], t(2068) = 0.88, p = 0.379; Std. beta = 0.74,
## 95% CI [-0.73, 2.21])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-20.18, 25.95], t(2068) = 0.25, p = 0.806; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.77, 95% CI [-29.83, 8.30], t(2068) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.08, 0.68])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 18.90, 95% CI [-4.65, 42.45], t(2068) = 1.57, p = 0.116; Std. beta = 0.82,
## 95% CI [-0.68, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.70, 95% CI [3.42, 21.98], t(2068) = 2.68, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.16, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.70, 95% CI [-0.58, 45.98], t(2068) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.69, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.63, 10.20], t(2068) = 1.16, p = 0.248; Std. beta = 0.16, 95%
## CI [-0.23, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.72, 24.28], t(2068) = 1.85, p = 0.065; Std. beta = 0.47,
## 95% CI [-0.29, 1.23])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.52, 6.32], t(2068) = 0.13, p = 0.895; Std. beta = 0.21, 95%
## CI [-0.16, 0.58])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-16.90, 9.11], t(2068) = -0.59, p = 0.557; Std. beta = 0.35,
## 95% CI [-0.55, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-0.94, 11.94], t(2068) = 1.67, p = 0.094; Std. beta = 0.30, 95%
## CI [-0.09, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-12.09, 4.30], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-27.17, 19.79], t(2068) = -0.31, p = 0.758; Std. beta = 0.47,
## 95% CI [-1.11, 2.06])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-17.73, 19.95], t(2068) = 0.12, p = 0.908; Std. beta = 0.66,
## 95% CI [-0.47, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.08, 95% CI [-21.18, 47.34], t(2068) = 0.75, p = 0.454; Std. beta = 0.77,
## 95% CI [-1.25, 2.79])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 12.61, 95% CI [-2.28, 27.50], t(2068) = 1.66, p = 0.097; Std. beta = 0.99,
## 95% CI [0.06, 1.93])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.02, 95% CI [-11.12, 35.16], t(2068) = 1.02, p = 0.308; Std. beta = 0.69,
## 95% CI [-0.77, 2.15])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.75, 95% CI [-0.68, 34.17], t(2068) = 1.88, p = 0.060; Std. beta = 0.84,
## 95% CI [-0.23, 1.91])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-21.21, 37.78], t(2068) = 0.55, p = 0.582; Std. beta = 0.79,
## 95% CI [-1.83, 3.40])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.75, 95% CI [-60.80, 5.29], t(2068) = -1.65, p = 0.100; Std. beta = -1.90,
## 95% CI [-4.29, 0.49])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.58, 95% CI [-29.30, 0.14], t(2068) = -1.94, p = 0.052; Std. beta = -0.64,
## 95% CI [-1.57, 0.28])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-28.23, 37.98], t(2068) = 0.29, p = 0.773; Std. beta = 0.29,
## 95% CI [-1.67, 2.24])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-25.65, 22.07], t(2068) = -0.15, p = 0.883; Std. beta = 0.44,
## 95% CI [-1.70, 2.58])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.59, 95% CI [-12.18, 21.36], t(2068) = 0.54, p = 0.592; Std. beta = 0.50,
## 95% CI [-0.65, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-10.96, 16.50], t(2068) = 0.40, p = 0.692; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.75, 95% CI [-29.52, 35.03], t(2068) = 0.17, p = 0.867; Std. beta = 0.54,
## 95% CI [-1.38, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-8.27, 12.70], t(2068) = 0.41, p = 0.679; Std. beta = -0.17,
## 95% CI [-0.86, 0.52])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-30.51, 2.36], t(2068) = -1.68, p = 0.093; Std. beta = -0.75,
## 95% CI [-1.96, 0.47])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.50, 95% CI [-6.04, 19.04], t(2068) = 1.02, p = 0.310; Std. beta = 0.38, 95%
## CI [-0.39, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-11.61, 15.64], t(2068) = 0.29, p = 0.772; Std. beta = -0.45,
## 95% CI [-1.29, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-18.68, 19.70], t(2068) = 0.05, p = 0.959; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-35.26, 30.38], t(2068) = -0.15, p = 0.884; Std. beta = -0.18,
## 95% CI [-2.11, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-9.71, 19.64], t(2068) = 0.66, p = 0.507; Std. beta = 0.37, 95%
## CI [-0.51, 1.24])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-17.03, 26.65], t(2068) = 0.43, p = 0.666; Std. beta = -0.19,
## 95% CI [-1.60, 1.22])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.90, 95% CI [-38.28, -1.53], t(2068) = -2.12, p = 0.034; Std. beta = -0.94,
## 95% CI [-2.14, 0.27])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-9.29, 15.91], t(2068) = 0.51, p = 0.607; Std. beta = 0.15, 95%
## CI [-0.63, 0.93])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-12.10, 26.37], t(2068) = 0.73, p = 0.467; Std. beta = 1.47,
## 95% CI [0.26, 2.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.59, 1.94], t(2068) = -1.70, p = 0.089; Std. beta = -0.47,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.49, 95% CI [-2.86, 29.84], t(2068) = 1.62, p = 0.106; Std. beta = 0.59,
## 95% CI [-0.41, 1.58])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.98, 95% CI [1.88, 24.08], t(2068) = 2.29, p = 0.022; Std. beta = 0.50, 95%
## CI [-0.18, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.24, 95% CI [-14.46, 50.94], t(2068) = 1.09, p = 0.274; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.83, 95% CI [3.48, 50.17], t(2068) = 2.25, p = 0.024; Std. beta = 1.58, 95%
## CI [0.08, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-19.74, 18.25], t(2068) = -0.08, p = 0.939; Std. beta = 0.06,
## 95% CI [-1.26, 1.37])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-9.90, 10.70], t(2068) = 0.08, p = 0.940; Std. beta = 0.14, 95%
## CI [-0.82, 1.10])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.70, 95% CI [-3.28, 4.68], t(2068) =
## 0.35, p = 0.730; Std. beta = 0.02, 95% CI [-0.09, 0.12])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.08, 95% CI [-43.94, 13.78], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.04, 11.18], t(2068) = 0.21, p = 0.835; Std.
## beta = 0.12, 95% CI [-0.97, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.07, 95% CI [-15.86, 5.72], t(2068) = -0.92, p = 0.357; Std.
## beta = -0.54, 95% CI [-1.70, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.95, 11.40], t(2068) = -0.12, p = 0.901;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.69, 6.17], t(2068) = -0.68, p = 0.498; Std.
## beta = -0.35, 95% CI [-1.36, 0.66])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.94, 95% CI [-6.63, -1.25], t(2068) = -2.87, p = 0.004; Std.
## beta = -0.42, 95% CI [-0.71, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.65, 1.90], t(2068) = -1.51, p = 0.131; Std.
## beta = -0.68, 95% CI [-1.57, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-2.77, 1.42], t(2068) = -0.63, p = 0.526; Std.
## beta = -0.07, 95% CI [-0.30, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-6.59, 1.60], t(2068) = -1.19, p = 0.232; Std.
## beta = -0.27, 95% CI [-0.71, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.09, 95% CI [0.02, 4.17], t(2068) = 1.98, p = 0.048; Std.
## beta = 0.22, 95% CI [2.06e-03, 0.45])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-0.26, 13.35], t(2068) = 1.89, p = 0.059; Std.
## beta = 0.70, 95% CI [-0.03, 1.43])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.93], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.02, 95% CI [-0.26, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.03, 5.12], t(2068) = 1.31, p = 0.192; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.77, 95% CI [-5.37, 20.90], t(2068) = 1.16, p = 0.246; Std.
## beta = 0.83, 95% CI [-0.58, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.67, 95% CI [0.69, 12.65], t(2068) = 2.19, p = 0.029; Std.
## beta = 0.72, 95% CI [0.07, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-2.65, 8.23], t(2068) = 1.01, p = 0.315; Std.
## beta = 0.30, 95% CI [-0.28, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.25, 7.73], t(2068) = -0.06, p = 0.949; Std.
## beta = -0.03, 95% CI [-0.89, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.60, 6.20], t(2068) = -0.42, p = 0.673; Std.
## beta = -0.18, 95% CI [-1.03, 0.67])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-33.78, 40.43], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.36, 95% CI [-3.63, 4.34])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-25.22, 19.31], t(2068) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.71, 7.56], t(2068) = 0.93, p = 0.354; Std.
## beta = 0.26, 95% CI [-0.29, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-15.05, 27.36], t(2068) = 0.57, p = 0.569; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-6.39, 11.52], t(2068) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.69, 1.24])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.40, 6.94], t(2068) = 0.25, p = 0.806; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.61, 13.06], t(2068) = 0.94, p = 0.348; Std.
## beta = 0.45, 95% CI [-0.50, 1.40])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.39, 95% CI [-8.64, 1.85], t(2068) = -1.27, p = 0.205; Std.
## beta = -0.36, 95% CI [-0.93, 0.20])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.21, 11.08], t(2068) = 0.18, p = 0.856; Std.
## beta = 0.10, 95% CI [-0.99, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 9.85e-03, 95% CI [-4.50, 4.52], t(2068) = 4.28e-03, p = 0.997;
## Std. beta = 1.05e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.68, -1.08], t(2068) = -2.36, p = 0.018;
## Std. beta = -0.69, 95% CI [-1.26, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.18, 95% CI [-32.67, 10.31], t(2068) = -1.02, p = 0.308;
## Std. beta = -1.20, 95% CI [-3.51, 1.11])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-9.68, 8.82], t(2068) = -0.09, p = 0.928; Std.
## beta = -0.05, 95% CI [-1.04, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-3.01, 4.65], t(2068) = 0.42, p = 0.674; Std.
## beta = 0.09, 95% CI [-0.32, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.31, 3.73], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.57, 95% CI [-1.54, 0.40])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-5.22, 10.54], t(2068) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-5.04, 4.10], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.05, 95% CI [-0.54, 0.44])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.80, 95% CI [3.72, 19.87], t(2068) = 2.86, p = 0.004; Std.
## beta = 1.27, 95% CI [0.40, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-2.29, 8.75], t(2068) = 1.15, p = 0.252; Std.
## beta = 0.35, 95% CI [-0.25, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.33, 95% CI [-7.66, 3.01], t(2068) = -0.86, p = 0.393; Std.
## beta = -0.25, 95% CI [-0.82, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.61, 0.57], t(2068) = -1.65, p = 0.099; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.18, 95% CI [-62.92, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-8.76, 8.64], t(2068) = -0.01, p = 0.989; Std.
## beta = -6.60e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.65, 11.96], t(2068) = 0.21, p = 0.834; Std.
## beta = 0.12, 95% CI [-1.04, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-9.25, 11.88], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.14, 95% CI [-0.99, 1.28])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## Soil_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to Soil_5yrPreCensor = 0, is at 56.99 (95% CI [51.37, 62.60],
## t(2068) = 19.90, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.50, 95% CI [-6.65, -2.35], t(2068) = -4.11, p < .001; Std. beta = -0.45, 95%
## CI [-0.55, -0.35])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.24, 95% CI [-5.08, 15.57], t(2068) = 1.00, p = 0.320; Std. beta =
## 0.09, 95% CI [-0.07, 0.25])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-40.63, 25.35], t(2068) = -0.45, p = 0.650; Std. beta = -1.80,
## 95% CI [-4.60, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.89, 95% CI [-13.39, 35.17], t(2068) = 0.88, p = 0.379; Std. beta = 0.74,
## 95% CI [-0.73, 2.21])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-20.18, 25.95], t(2068) = 0.25, p = 0.806; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.77, 95% CI [-29.83, 8.30], t(2068) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.08, 0.68])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 18.90, 95% CI [-4.65, 42.45], t(2068) = 1.57, p = 0.116; Std. beta = 0.82,
## 95% CI [-0.68, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.70, 95% CI [3.42, 21.98], t(2068) = 2.68, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.16, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.70, 95% CI [-0.58, 45.98], t(2068) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.69, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.63, 10.20], t(2068) = 1.16, p = 0.248; Std. beta = 0.16, 95%
## CI [-0.23, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.72, 24.28], t(2068) = 1.85, p = 0.065; Std. beta = 0.47,
## 95% CI [-0.29, 1.23])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.52, 6.32], t(2068) = 0.13, p = 0.895; Std. beta = 0.21, 95%
## CI [-0.16, 0.58])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-16.90, 9.11], t(2068) = -0.59, p = 0.557; Std. beta = 0.35,
## 95% CI [-0.55, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-0.94, 11.94], t(2068) = 1.67, p = 0.094; Std. beta = 0.30, 95%
## CI [-0.09, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-12.09, 4.30], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-27.17, 19.79], t(2068) = -0.31, p = 0.758; Std. beta = 0.47,
## 95% CI [-1.11, 2.06])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-17.73, 19.95], t(2068) = 0.12, p = 0.908; Std. beta = 0.66,
## 95% CI [-0.47, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.08, 95% CI [-21.18, 47.34], t(2068) = 0.75, p = 0.454; Std. beta = 0.77,
## 95% CI [-1.25, 2.79])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 12.61, 95% CI [-2.28, 27.50], t(2068) = 1.66, p = 0.097; Std. beta = 0.99,
## 95% CI [0.06, 1.93])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.02, 95% CI [-11.12, 35.16], t(2068) = 1.02, p = 0.308; Std. beta = 0.69,
## 95% CI [-0.77, 2.15])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.75, 95% CI [-0.68, 34.17], t(2068) = 1.88, p = 0.060; Std. beta = 0.84,
## 95% CI [-0.23, 1.91])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-21.21, 37.78], t(2068) = 0.55, p = 0.582; Std. beta = 0.79,
## 95% CI [-1.83, 3.40])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.75, 95% CI [-60.80, 5.29], t(2068) = -1.65, p = 0.100; Std. beta = -1.90,
## 95% CI [-4.29, 0.49])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.58, 95% CI [-29.30, 0.14], t(2068) = -1.94, p = 0.052; Std. beta = -0.64,
## 95% CI [-1.57, 0.28])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-28.23, 37.98], t(2068) = 0.29, p = 0.773; Std. beta = 0.29,
## 95% CI [-1.67, 2.24])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-25.65, 22.07], t(2068) = -0.15, p = 0.883; Std. beta = 0.44,
## 95% CI [-1.70, 2.58])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.59, 95% CI [-12.18, 21.36], t(2068) = 0.54, p = 0.592; Std. beta = 0.50,
## 95% CI [-0.65, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-10.96, 16.50], t(2068) = 0.40, p = 0.692; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.75, 95% CI [-29.52, 35.03], t(2068) = 0.17, p = 0.867; Std. beta = 0.54,
## 95% CI [-1.38, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-8.27, 12.70], t(2068) = 0.41, p = 0.679; Std. beta = -0.17,
## 95% CI [-0.86, 0.52])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-30.51, 2.36], t(2068) = -1.68, p = 0.093; Std. beta = -0.75,
## 95% CI [-1.96, 0.47])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.50, 95% CI [-6.04, 19.04], t(2068) = 1.02, p = 0.310; Std. beta = 0.38, 95%
## CI [-0.39, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-11.61, 15.64], t(2068) = 0.29, p = 0.772; Std. beta = -0.45,
## 95% CI [-1.29, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-18.68, 19.70], t(2068) = 0.05, p = 0.959; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-35.26, 30.38], t(2068) = -0.15, p = 0.884; Std. beta = -0.18,
## 95% CI [-2.11, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-9.71, 19.64], t(2068) = 0.66, p = 0.507; Std. beta = 0.37, 95%
## CI [-0.51, 1.24])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-17.03, 26.65], t(2068) = 0.43, p = 0.666; Std. beta = -0.19,
## 95% CI [-1.60, 1.22])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.90, 95% CI [-38.28, -1.53], t(2068) = -2.12, p = 0.034; Std. beta = -0.94,
## 95% CI [-2.14, 0.27])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-9.29, 15.91], t(2068) = 0.51, p = 0.607; Std. beta = 0.15, 95%
## CI [-0.63, 0.93])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-12.10, 26.37], t(2068) = 0.73, p = 0.467; Std. beta = 1.47,
## 95% CI [0.26, 2.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.59, 1.94], t(2068) = -1.70, p = 0.089; Std. beta = -0.47,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.49, 95% CI [-2.86, 29.84], t(2068) = 1.62, p = 0.106; Std. beta = 0.59,
## 95% CI [-0.41, 1.58])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.98, 95% CI [1.88, 24.08], t(2068) = 2.29, p = 0.022; Std. beta = 0.50, 95%
## CI [-0.18, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.24, 95% CI [-14.46, 50.94], t(2068) = 1.09, p = 0.274; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.83, 95% CI [3.48, 50.17], t(2068) = 2.25, p = 0.024; Std. beta = 1.58, 95%
## CI [0.08, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-19.74, 18.25], t(2068) = -0.08, p = 0.939; Std. beta = 0.06,
## 95% CI [-1.26, 1.37])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-9.90, 10.70], t(2068) = 0.08, p = 0.940; Std. beta = 0.14, 95%
## CI [-0.82, 1.10])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.70, 95% CI [-3.28, 4.68], t(2068) =
## 0.35, p = 0.730; Std. beta = 0.02, 95% CI [-0.09, 0.12])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.08, 95% CI [-43.94, 13.78], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.04, 11.18], t(2068) = 0.21, p = 0.835; Std.
## beta = 0.12, 95% CI [-0.97, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.07, 95% CI [-15.86, 5.72], t(2068) = -0.92, p = 0.357; Std.
## beta = -0.54, 95% CI [-1.70, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.95, 11.40], t(2068) = -0.12, p = 0.901;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.69, 6.17], t(2068) = -0.68, p = 0.498; Std.
## beta = -0.35, 95% CI [-1.36, 0.66])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.94, 95% CI [-6.63, -1.25], t(2068) = -2.87, p = 0.004; Std.
## beta = -0.42, 95% CI [-0.71, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.65, 1.90], t(2068) = -1.51, p = 0.131; Std.
## beta = -0.68, 95% CI [-1.57, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-2.77, 1.42], t(2068) = -0.63, p = 0.526; Std.
## beta = -0.07, 95% CI [-0.30, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-6.59, 1.60], t(2068) = -1.19, p = 0.232; Std.
## beta = -0.27, 95% CI [-0.71, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.09, 95% CI [0.02, 4.17], t(2068) = 1.98, p = 0.048; Std.
## beta = 0.22, 95% CI [2.06e-03, 0.45])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-0.26, 13.35], t(2068) = 1.89, p = 0.059; Std.
## beta = 0.70, 95% CI [-0.03, 1.43])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.93], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.02, 95% CI [-0.26, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.03, 5.12], t(2068) = 1.31, p = 0.192; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.77, 95% CI [-5.37, 20.90], t(2068) = 1.16, p = 0.246; Std.
## beta = 0.83, 95% CI [-0.58, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.67, 95% CI [0.69, 12.65], t(2068) = 2.19, p = 0.029; Std.
## beta = 0.72, 95% CI [0.07, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-2.65, 8.23], t(2068) = 1.01, p = 0.315; Std.
## beta = 0.30, 95% CI [-0.28, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.25, 7.73], t(2068) = -0.06, p = 0.949; Std.
## beta = -0.03, 95% CI [-0.89, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.60, 6.20], t(2068) = -0.42, p = 0.673; Std.
## beta = -0.18, 95% CI [-1.03, 0.67])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-33.78, 40.43], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.36, 95% CI [-3.63, 4.34])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-25.22, 19.31], t(2068) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.71, 7.56], t(2068) = 0.93, p = 0.354; Std.
## beta = 0.26, 95% CI [-0.29, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-15.05, 27.36], t(2068) = 0.57, p = 0.569; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-6.39, 11.52], t(2068) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.69, 1.24])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.40, 6.94], t(2068) = 0.25, p = 0.806; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.61, 13.06], t(2068) = 0.94, p = 0.348; Std.
## beta = 0.45, 95% CI [-0.50, 1.40])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.39, 95% CI [-8.64, 1.85], t(2068) = -1.27, p = 0.205; Std.
## beta = -0.36, 95% CI [-0.93, 0.20])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.21, 11.08], t(2068) = 0.18, p = 0.856; Std.
## beta = 0.10, 95% CI [-0.99, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 9.85e-03, 95% CI [-4.50, 4.52], t(2068) = 4.28e-03, p = 0.997;
## Std. beta = 1.05e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.68, -1.08], t(2068) = -2.36, p = 0.018;
## Std. beta = -0.69, 95% CI [-1.26, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.18, 95% CI [-32.67, 10.31], t(2068) = -1.02, p = 0.308;
## Std. beta = -1.20, 95% CI [-3.51, 1.11])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-9.68, 8.82], t(2068) = -0.09, p = 0.928; Std.
## beta = -0.05, 95% CI [-1.04, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-3.01, 4.65], t(2068) = 0.42, p = 0.674; Std.
## beta = 0.09, 95% CI [-0.32, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.31, 3.73], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.57, 95% CI [-1.54, 0.40])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-5.22, 10.54], t(2068) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-5.04, 4.10], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.05, 95% CI [-0.54, 0.44])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.80, 95% CI [3.72, 19.87], t(2068) = 2.86, p = 0.004; Std.
## beta = 1.27, 95% CI [0.40, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-2.29, 8.75], t(2068) = 1.15, p = 0.252; Std.
## beta = 0.35, 95% CI [-0.25, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.33, 95% CI [-7.66, 3.01], t(2068) = -0.86, p = 0.393; Std.
## beta = -0.25, 95% CI [-0.82, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.61, 0.57], t(2068) = -1.65, p = 0.099; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.18, 95% CI [-62.92, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-8.76, 8.64], t(2068) = -0.01, p = 0.989; Std.
## beta = -6.60e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.65, 11.96], t(2068) = 0.21, p = 0.834; Std.
## beta = 0.12, 95% CI [-1.04, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-9.25, 11.88], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.14, 95% CI [-0.99, 1.28])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.94) and the part related to the fixed effects
## alone (marginal R2) is of 0.21. The model's intercept, corresponding to site =
## Simmons, is at 56.99 (95% CI [51.37, 62.60], t(2068) = 19.90, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.50, 95% CI [-6.65, -2.35], t(2068) = -4.11, p < .001; Std. beta = -0.45, 95%
## CI [-0.55, -0.35])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.24, 95% CI [-5.08, 15.57], t(2068) = 1.00, p = 0.320; Std. beta =
## 0.09, 95% CI [-0.07, 0.25])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-40.63, 25.35], t(2068) = -0.45, p = 0.650; Std. beta = -1.80,
## 95% CI [-4.60, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.89, 95% CI [-13.39, 35.17], t(2068) = 0.88, p = 0.379; Std. beta = 0.74,
## 95% CI [-0.73, 2.21])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-20.18, 25.95], t(2068) = 0.25, p = 0.806; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.77, 95% CI [-29.83, 8.30], t(2068) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.08, 0.68])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 18.90, 95% CI [-4.65, 42.45], t(2068) = 1.57, p = 0.116; Std. beta = 0.82,
## 95% CI [-0.68, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.70, 95% CI [3.42, 21.98], t(2068) = 2.68, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.16, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.70, 95% CI [-0.58, 45.98], t(2068) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.69, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.63, 10.20], t(2068) = 1.16, p = 0.248; Std. beta = 0.16, 95%
## CI [-0.23, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.72, 24.28], t(2068) = 1.85, p = 0.065; Std. beta = 0.47,
## 95% CI [-0.29, 1.23])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.52, 6.32], t(2068) = 0.13, p = 0.895; Std. beta = 0.21, 95%
## CI [-0.16, 0.58])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-16.90, 9.11], t(2068) = -0.59, p = 0.557; Std. beta = 0.35,
## 95% CI [-0.55, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-0.94, 11.94], t(2068) = 1.67, p = 0.094; Std. beta = 0.30, 95%
## CI [-0.09, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-12.09, 4.30], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-27.17, 19.79], t(2068) = -0.31, p = 0.758; Std. beta = 0.47,
## 95% CI [-1.11, 2.06])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-17.73, 19.95], t(2068) = 0.12, p = 0.908; Std. beta = 0.66,
## 95% CI [-0.47, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.08, 95% CI [-21.18, 47.34], t(2068) = 0.75, p = 0.454; Std. beta = 0.77,
## 95% CI [-1.25, 2.79])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 12.61, 95% CI [-2.28, 27.50], t(2068) = 1.66, p = 0.097; Std. beta = 0.99,
## 95% CI [0.06, 1.93])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.02, 95% CI [-11.12, 35.16], t(2068) = 1.02, p = 0.308; Std. beta = 0.69,
## 95% CI [-0.77, 2.15])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.75, 95% CI [-0.68, 34.17], t(2068) = 1.88, p = 0.060; Std. beta = 0.84,
## 95% CI [-0.23, 1.91])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-21.21, 37.78], t(2068) = 0.55, p = 0.582; Std. beta = 0.79,
## 95% CI [-1.83, 3.40])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.75, 95% CI [-60.80, 5.29], t(2068) = -1.65, p = 0.100; Std. beta = -1.90,
## 95% CI [-4.29, 0.49])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.58, 95% CI [-29.30, 0.14], t(2068) = -1.94, p = 0.052; Std. beta = -0.64,
## 95% CI [-1.57, 0.28])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-28.23, 37.98], t(2068) = 0.29, p = 0.773; Std. beta = 0.29,
## 95% CI [-1.67, 2.24])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-25.65, 22.07], t(2068) = -0.15, p = 0.883; Std. beta = 0.44,
## 95% CI [-1.70, 2.58])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.59, 95% CI [-12.18, 21.36], t(2068) = 0.54, p = 0.592; Std. beta = 0.50,
## 95% CI [-0.65, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-10.96, 16.50], t(2068) = 0.40, p = 0.692; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.75, 95% CI [-29.52, 35.03], t(2068) = 0.17, p = 0.867; Std. beta = 0.54,
## 95% CI [-1.38, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-8.27, 12.70], t(2068) = 0.41, p = 0.679; Std. beta = -0.17,
## 95% CI [-0.86, 0.52])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-30.51, 2.36], t(2068) = -1.68, p = 0.093; Std. beta = -0.75,
## 95% CI [-1.96, 0.47])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.50, 95% CI [-6.04, 19.04], t(2068) = 1.02, p = 0.310; Std. beta = 0.38, 95%
## CI [-0.39, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-11.61, 15.64], t(2068) = 0.29, p = 0.772; Std. beta = -0.45,
## 95% CI [-1.29, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-18.68, 19.70], t(2068) = 0.05, p = 0.959; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-35.26, 30.38], t(2068) = -0.15, p = 0.884; Std. beta = -0.18,
## 95% CI [-2.11, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-9.71, 19.64], t(2068) = 0.66, p = 0.507; Std. beta = 0.37, 95%
## CI [-0.51, 1.24])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-17.03, 26.65], t(2068) = 0.43, p = 0.666; Std. beta = -0.19,
## 95% CI [-1.60, 1.22])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.90, 95% CI [-38.28, -1.53], t(2068) = -2.12, p = 0.034; Std. beta = -0.94,
## 95% CI [-2.14, 0.27])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-9.29, 15.91], t(2068) = 0.51, p = 0.607; Std. beta = 0.15, 95%
## CI [-0.63, 0.93])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-12.10, 26.37], t(2068) = 0.73, p = 0.467; Std. beta = 1.47,
## 95% CI [0.26, 2.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.59, 1.94], t(2068) = -1.70, p = 0.089; Std. beta = -0.47,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.49, 95% CI [-2.86, 29.84], t(2068) = 1.62, p = 0.106; Std. beta = 0.59,
## 95% CI [-0.41, 1.58])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.98, 95% CI [1.88, 24.08], t(2068) = 2.29, p = 0.022; Std. beta = 0.50, 95%
## CI [-0.18, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.24, 95% CI [-14.46, 50.94], t(2068) = 1.09, p = 0.274; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.83, 95% CI [3.48, 50.17], t(2068) = 2.25, p = 0.024; Std. beta = 1.58, 95%
## CI [0.08, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-19.74, 18.25], t(2068) = -0.08, p = 0.939; Std. beta = 0.06,
## 95% CI [-1.26, 1.37])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-9.90, 10.70], t(2068) = 0.08, p = 0.940; Std. beta = 0.14, 95%
## CI [-0.82, 1.10])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.70, 95% CI [-3.28, 4.68], t(2068) =
## 0.35, p = 0.730; Std. beta = 0.02, 95% CI [-0.09, 0.12])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.08, 95% CI [-43.94, 13.78], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.04, 11.18], t(2068) = 0.21, p = 0.835; Std.
## beta = 0.12, 95% CI [-0.97, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.07, 95% CI [-15.86, 5.72], t(2068) = -0.92, p = 0.357; Std.
## beta = -0.54, 95% CI [-1.70, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.95, 11.40], t(2068) = -0.12, p = 0.901;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.69, 6.17], t(2068) = -0.68, p = 0.498; Std.
## beta = -0.35, 95% CI [-1.36, 0.66])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.94, 95% CI [-6.63, -1.25], t(2068) = -2.87, p = 0.004; Std.
## beta = -0.42, 95% CI [-0.71, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.65, 1.90], t(2068) = -1.51, p = 0.131; Std.
## beta = -0.68, 95% CI [-1.57, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-2.77, 1.42], t(2068) = -0.63, p = 0.526; Std.
## beta = -0.07, 95% CI [-0.30, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-6.59, 1.60], t(2068) = -1.19, p = 0.232; Std.
## beta = -0.27, 95% CI [-0.71, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.09, 95% CI [0.02, 4.17], t(2068) = 1.98, p = 0.048; Std.
## beta = 0.22, 95% CI [2.06e-03, 0.45])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-0.26, 13.35], t(2068) = 1.89, p = 0.059; Std.
## beta = 0.70, 95% CI [-0.03, 1.43])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.93], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.02, 95% CI [-0.26, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.03, 5.12], t(2068) = 1.31, p = 0.192; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.77, 95% CI [-5.37, 20.90], t(2068) = 1.16, p = 0.246; Std.
## beta = 0.83, 95% CI [-0.58, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.67, 95% CI [0.69, 12.65], t(2068) = 2.19, p = 0.029; Std.
## beta = 0.72, 95% CI [0.07, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-2.65, 8.23], t(2068) = 1.01, p = 0.315; Std.
## beta = 0.30, 95% CI [-0.28, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.25, 7.73], t(2068) = -0.06, p = 0.949; Std.
## beta = -0.03, 95% CI [-0.89, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.60, 6.20], t(2068) = -0.42, p = 0.673; Std.
## beta = -0.18, 95% CI [-1.03, 0.67])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-33.78, 40.43], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.36, 95% CI [-3.63, 4.34])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-25.22, 19.31], t(2068) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.71, 7.56], t(2068) = 0.93, p = 0.354; Std.
## beta = 0.26, 95% CI [-0.29, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-15.05, 27.36], t(2068) = 0.57, p = 0.569; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-6.39, 11.52], t(2068) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.69, 1.24])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.40, 6.94], t(2068) = 0.25, p = 0.806; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.61, 13.06], t(2068) = 0.94, p = 0.348; Std.
## beta = 0.45, 95% CI [-0.50, 1.40])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.39, 95% CI [-8.64, 1.85], t(2068) = -1.27, p = 0.205; Std.
## beta = -0.36, 95% CI [-0.93, 0.20])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.21, 11.08], t(2068) = 0.18, p = 0.856; Std.
## beta = 0.10, 95% CI [-0.99, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 9.85e-03, 95% CI [-4.50, 4.52], t(2068) = 4.28e-03, p = 0.997;
## Std. beta = 1.05e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.68, -1.08], t(2068) = -2.36, p = 0.018;
## Std. beta = -0.69, 95% CI [-1.26, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.18, 95% CI [-32.67, 10.31], t(2068) = -1.02, p = 0.308;
## Std. beta = -1.20, 95% CI [-3.51, 1.11])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-9.68, 8.82], t(2068) = -0.09, p = 0.928; Std.
## beta = -0.05, 95% CI [-1.04, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-3.01, 4.65], t(2068) = 0.42, p = 0.674; Std.
## beta = 0.09, 95% CI [-0.32, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.31, 3.73], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.57, 95% CI [-1.54, 0.40])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-5.22, 10.54], t(2068) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-5.04, 4.10], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.05, 95% CI [-0.54, 0.44])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.80, 95% CI [3.72, 19.87], t(2068) = 2.86, p = 0.004; Std.
## beta = 1.27, 95% CI [0.40, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-2.29, 8.75], t(2068) = 1.15, p = 0.252; Std.
## beta = 0.35, 95% CI [-0.25, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.33, 95% CI [-7.66, 3.01], t(2068) = -0.86, p = 0.393; Std.
## beta = -0.25, 95% CI [-0.82, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.61, 0.57], t(2068) = -1.65, p = 0.099; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.18, 95% CI [-62.92, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-8.76, 8.64], t(2068) = -0.01, p = 0.989; Std.
## beta = -6.60e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.65, 11.96], t(2068) = 0.21, p = 0.834; Std.
## beta = 0.12, 95% CI [-1.04, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-9.25, 11.88], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.14, 95% CI [-0.99, 1.28])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.21. The model's intercept,
## corresponding to cohort = CARE-PF, is at 56.99 (95% CI [51.37, 62.60], t(2068)
## = 19.90, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.50, 95% CI [-6.65, -2.35], t(2068) = -4.11, p < .001; Std. beta = -0.45, 95%
## CI [-0.55, -0.35])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.24, 95% CI [-5.08, 15.57], t(2068) = 1.00, p = 0.320; Std. beta =
## 0.09, 95% CI [-0.07, 0.25])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-40.63, 25.35], t(2068) = -0.45, p = 0.650; Std. beta = -1.80,
## 95% CI [-4.60, 1.00])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 10.89, 95% CI [-13.39, 35.17], t(2068) = 0.88, p = 0.379; Std. beta = 0.74,
## 95% CI [-0.73, 2.21])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.89, 95% CI [-20.18, 25.95], t(2068) = 0.25, p = 0.806; Std. beta = -0.28,
## 95% CI [-1.80, 1.24])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -10.77, 95% CI [-29.83, 8.30], t(2068) = -1.11, p = 0.268; Std. beta = -0.70,
## 95% CI [-2.08, 0.68])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 18.90, 95% CI [-4.65, 42.45], t(2068) = 1.57, p = 0.116; Std. beta = 0.82,
## 95% CI [-0.68, 2.33])
## - The effect of site [07R] is statistically significant and positive (beta =
## 12.70, 95% CI [3.42, 21.98], t(2068) = 2.68, p = 0.007; Std. beta = 0.40, 95%
## CI [-0.16, 0.96])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 22.70, 95% CI [-0.58, 45.98], t(2068) = 1.91, p = 0.056; Std. beta = 0.77,
## 95% CI [-0.69, 2.24])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-2.63, 10.20], t(2068) = 1.16, p = 0.248; Std. beta = 0.16, 95%
## CI [-0.23, 0.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 11.78, 95% CI [-0.72, 24.28], t(2068) = 1.85, p = 0.065; Std. beta = 0.47,
## 95% CI [-0.29, 1.23])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-5.52, 6.32], t(2068) = 0.13, p = 0.895; Std. beta = 0.21, 95%
## CI [-0.16, 0.58])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-16.90, 9.11], t(2068) = -0.59, p = 0.557; Std. beta = 0.35,
## 95% CI [-0.55, 1.26])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.50, 95% CI [-0.94, 11.94], t(2068) = 1.67, p = 0.094; Std. beta = 0.30, 95%
## CI [-0.09, 0.70])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-12.09, 4.30], t(2068) = -0.93, p = 0.352; Std. beta = -0.05,
## 95% CI [-0.55, 0.45])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-27.17, 19.79], t(2068) = -0.31, p = 0.758; Std. beta = 0.47,
## 95% CI [-1.11, 2.06])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-17.73, 19.95], t(2068) = 0.12, p = 0.908; Std. beta = 0.66,
## 95% CI [-0.47, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 13.08, 95% CI [-21.18, 47.34], t(2068) = 0.75, p = 0.454; Std. beta = 0.77,
## 95% CI [-1.25, 2.79])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 12.61, 95% CI [-2.28, 27.50], t(2068) = 1.66, p = 0.097; Std. beta = 0.99,
## 95% CI [0.06, 1.93])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 12.02, 95% CI [-11.12, 35.16], t(2068) = 1.02, p = 0.308; Std. beta = 0.69,
## 95% CI [-0.77, 2.15])
## - The effect of site [13R] is statistically non-significant and positive (beta
## = 16.75, 95% CI [-0.68, 34.17], t(2068) = 1.88, p = 0.060; Std. beta = 0.84,
## 95% CI [-0.23, 1.91])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 8.29, 95% CI [-21.21, 37.78], t(2068) = 0.55, p = 0.582; Std. beta = 0.79,
## 95% CI [-1.83, 3.40])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -27.75, 95% CI [-60.80, 5.29], t(2068) = -1.65, p = 0.100; Std. beta = -1.90,
## 95% CI [-4.29, 0.49])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -14.58, 95% CI [-29.30, 0.14], t(2068) = -1.94, p = 0.052; Std. beta = -0.64,
## 95% CI [-1.57, 0.28])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 4.87, 95% CI [-28.23, 37.98], t(2068) = 0.29, p = 0.773; Std. beta = 0.29,
## 95% CI [-1.67, 2.24])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-25.65, 22.07], t(2068) = -0.15, p = 0.883; Std. beta = 0.44,
## 95% CI [-1.70, 2.58])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 4.59, 95% CI [-12.18, 21.36], t(2068) = 0.54, p = 0.592; Std. beta = 0.50,
## 95% CI [-0.65, 1.65])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-10.96, 16.50], t(2068) = 0.40, p = 0.692; Std. beta = 0.23,
## 95% CI [-0.66, 1.12])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 2.75, 95% CI [-29.52, 35.03], t(2068) = 0.17, p = 0.867; Std. beta = 0.54,
## 95% CI [-1.38, 2.46])
## - The effect of site [22R] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-8.27, 12.70], t(2068) = 0.41, p = 0.679; Std. beta = -0.17,
## 95% CI [-0.86, 0.52])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-30.51, 2.36], t(2068) = -1.68, p = 0.093; Std. beta = -0.75,
## 95% CI [-1.96, 0.47])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 6.50, 95% CI [-6.04, 19.04], t(2068) = 1.02, p = 0.310; Std. beta = 0.38, 95%
## CI [-0.39, 1.15])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 2.02, 95% CI [-11.61, 15.64], t(2068) = 0.29, p = 0.772; Std. beta = -0.45,
## 95% CI [-1.29, 0.39])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-18.68, 19.70], t(2068) = 0.05, p = 0.959; Std. beta = -0.97,
## 95% CI [-3.04, 1.10])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-35.26, 30.38], t(2068) = -0.15, p = 0.884; Std. beta = -0.18,
## 95% CI [-2.11, 1.75])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-9.71, 19.64], t(2068) = 0.66, p = 0.507; Std. beta = 0.37, 95%
## CI [-0.51, 1.24])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.81, 95% CI [-17.03, 26.65], t(2068) = 0.43, p = 0.666; Std. beta = -0.19,
## 95% CI [-1.60, 1.22])
## - The effect of site [33R] is statistically significant and negative (beta =
## -19.90, 95% CI [-38.28, -1.53], t(2068) = -2.12, p = 0.034; Std. beta = -0.94,
## 95% CI [-2.14, 0.27])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-9.29, 15.91], t(2068) = 0.51, p = 0.607; Std. beta = 0.15, 95%
## CI [-0.63, 0.93])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-12.10, 26.37], t(2068) = 0.73, p = 0.467; Std. beta = 1.47,
## 95% CI [0.26, 2.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.59, 1.94], t(2068) = -1.70, p = 0.089; Std. beta = -0.47,
## 95% CI [-1.40, 0.47])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 13.49, 95% CI [-2.86, 29.84], t(2068) = 1.62, p = 0.106; Std. beta = 0.59,
## 95% CI [-0.41, 1.58])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.98, 95% CI [1.88, 24.08], t(2068) = 2.29, p = 0.022; Std. beta = 0.50, 95%
## CI [-0.18, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 18.24, 95% CI [-14.46, 50.94], t(2068) = 1.09, p = 0.274; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically significant and positive (beta =
## 26.83, 95% CI [3.48, 50.17], t(2068) = 2.25, p = 0.024; Std. beta = 1.58, 95%
## CI [0.08, 3.07])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -0.74, 95% CI [-19.74, 18.25], t(2068) = -0.08, p = 0.939; Std. beta = 0.06,
## 95% CI [-1.26, 1.37])
## - The effect of site [42R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-9.90, 10.70], t(2068) = 0.08, p = 0.940; Std. beta = 0.14, 95%
## CI [-0.82, 1.10])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.70, 95% CI [-3.28, 4.68], t(2068) =
## 0.35, p = 0.730; Std. beta = 0.02, 95% CI [-0.09, 0.12])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -15.08, 95% CI [-43.94, 13.78], t(2068) = -1.03, p = 0.305;
## Std. beta = -1.62, 95% CI [-4.72, 1.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.07, 95% CI [-9.04, 11.18], t(2068) = 0.21, p = 0.835; Std.
## beta = 0.12, 95% CI [-0.97, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -5.07, 95% CI [-15.86, 5.72], t(2068) = -0.92, p = 0.357; Std.
## beta = -0.54, 95% CI [-1.70, 0.61])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.95, 11.40], t(2068) = -0.12, p = 0.901;
## Std. beta = -0.08, 95% CI [-1.39, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-12.69, 6.17], t(2068) = -0.68, p = 0.498; Std.
## beta = -0.35, 95% CI [-1.36, 0.66])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.94, 95% CI [-6.63, -1.25], t(2068) = -2.87, p = 0.004; Std.
## beta = -0.42, 95% CI [-0.71, -0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.37, 95% CI [-14.65, 1.90], t(2068) = -1.51, p = 0.131; Std.
## beta = -0.68, 95% CI [-1.57, 0.20])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-2.77, 1.42], t(2068) = -0.63, p = 0.526; Std.
## beta = -0.07, 95% CI [-0.30, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-6.59, 1.60], t(2068) = -1.19, p = 0.232; Std.
## beta = -0.27, 95% CI [-0.71, 0.17])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.09, 95% CI [0.02, 4.17], t(2068) = 1.98, p = 0.048; Std.
## beta = 0.22, 95% CI [2.06e-03, 0.45])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 6.55, 95% CI [-0.26, 13.35], t(2068) = 1.89, p = 0.059; Std.
## beta = 0.70, 95% CI [-0.03, 1.43])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.40, 1.93], t(2068) = -0.21, p = 0.833; Std.
## beta = -0.02, 95% CI [-0.26, 0.21])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.03, 5.12], t(2068) = 1.31, p = 0.192; Std.
## beta = 0.22, 95% CI [-0.11, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.77, 95% CI [-5.37, 20.90], t(2068) = 1.16, p = 0.246; Std.
## beta = 0.83, 95% CI [-0.58, 2.25])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.67, 95% CI [0.69, 12.65], t(2068) = 2.19, p = 0.029; Std.
## beta = 0.72, 95% CI [0.07, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-2.65, 8.23], t(2068) = 1.01, p = 0.315; Std.
## beta = 0.30, 95% CI [-0.28, 0.88])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-8.25, 7.73], t(2068) = -0.06, p = 0.949; Std.
## beta = -0.03, 95% CI [-0.89, 0.83])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.70, 95% CI [-9.60, 6.20], t(2068) = -0.42, p = 0.673; Std.
## beta = -0.18, 95% CI [-1.03, 0.67])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.32, 95% CI [-33.78, 40.43], t(2068) = 0.18, p = 0.861; Std.
## beta = 0.36, 95% CI [-3.63, 4.34])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-25.22, 19.31], t(2068) = -0.26, p = 0.795;
## Std. beta = -0.32, 95% CI [-2.71, 2.07])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.43, 95% CI [-2.71, 7.56], t(2068) = 0.93, p = 0.354; Std.
## beta = 0.26, 95% CI [-0.29, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-15.05, 27.36], t(2068) = 0.57, p = 0.569; Std.
## beta = 0.66, 95% CI [-1.62, 2.94])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.57, 95% CI [-6.39, 11.52], t(2068) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.69, 1.24])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.77, 95% CI [-5.40, 6.94], t(2068) = 0.25, p = 0.806; Std.
## beta = 0.08, 95% CI [-0.58, 0.75])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.23, 95% CI [-4.61, 13.06], t(2068) = 0.94, p = 0.348; Std.
## beta = 0.45, 95% CI [-0.50, 1.40])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -3.39, 95% CI [-8.64, 1.85], t(2068) = -1.27, p = 0.205; Std.
## beta = -0.36, 95% CI [-0.93, 0.20])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-9.21, 11.08], t(2068) = 0.18, p = 0.856; Std.
## beta = 0.10, 95% CI [-0.99, 1.19])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 9.85e-03, 95% CI [-4.50, 4.52], t(2068) = 4.28e-03, p = 0.997;
## Std. beta = 1.05e-03, 95% CI [-0.48, 0.49])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -6.38, 95% CI [-11.68, -1.08], t(2068) = -2.36, p = 0.018;
## Std. beta = -0.69, 95% CI [-1.26, -0.12])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -11.18, 95% CI [-32.67, 10.31], t(2068) = -1.02, p = 0.308;
## Std. beta = -1.20, 95% CI [-3.51, 1.11])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-9.68, 8.82], t(2068) = -0.09, p = 0.928; Std.
## beta = -0.05, 95% CI [-1.04, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 0.82, 95% CI [-3.01, 4.65], t(2068) = 0.42, p = 0.674; Std.
## beta = 0.09, 95% CI [-0.32, 0.50])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.31, 3.73], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.57, 95% CI [-1.54, 0.40])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-5.22, 10.54], t(2068) = 0.66, p = 0.509; Std.
## beta = 0.29, 95% CI [-0.56, 1.13])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.47, 95% CI [-5.04, 4.10], t(2068) = -0.20, p = 0.839; Std.
## beta = -0.05, 95% CI [-0.54, 0.44])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.80, 95% CI [3.72, 19.87], t(2068) = 2.86, p = 0.004; Std.
## beta = 1.27, 95% CI [0.40, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-2.29, 8.75], t(2068) = 1.15, p = 0.252; Std.
## beta = 0.35, 95% CI [-0.25, 0.94])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.33, 95% CI [-7.66, 3.01], t(2068) = -0.86, p = 0.393; Std.
## beta = -0.25, 95% CI [-0.82, 0.32])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-6.61, 0.57], t(2068) = -1.65, p = 0.099; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.18, 95% CI [-62.92, -29.45], t(2068) = -5.41, p < .001;
## Std. beta = -4.96, 95% CI [-6.76, -3.16])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-8.76, 8.64], t(2068) = -0.01, p = 0.989; Std.
## beta = -6.60e-03, 95% CI [-0.94, 0.93])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-9.65, 11.96], t(2068) = 0.21, p = 0.834; Std.
## beta = 0.12, 95% CI [-1.04, 1.29])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-9.25, 11.88], t(2068) = 0.24, p = 0.807; Std.
## beta = 0.14, 95% CI [-0.99, 1.28])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.FVC_lmer2 <- lmer(fvc_pct ~ 1 + time_firstPFT*Soil_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(FVC_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14367.4
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -5.2866 -0.4404 -0.0080 0.4469 4.5156
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 232.73 15.256
## time_firstPFT 13.52 3.677 -0.07
## Residual 25.62 5.062
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 29.87621 6.36844 4.691
## time_firstPFT -1.71082 2.39099 -0.716
## Soil_5yrPreCensor 5.49093 5.08574 1.080
## disadv 3.90403 2.88201 1.355
## dich_RaceNon-White -7.68480 2.80820 -2.737
## sexF 3.72580 1.74349 2.137
## age_dx 0.38006 0.09115 4.170
## smokeHxFormer 3.64210 1.72885 2.107
## smokeHxAlways 18.51298 8.40992 2.201
## smokeHxUnknown -2.60559 3.92822 -0.663
## site02R -11.12536 16.17834 -0.688
## site03R 8.85481 12.00191 0.738
## site04R 2.45160 11.26272 0.218
## site05R -12.22869 9.35625 -1.307
## site06R 9.46334 16.17364 0.585
## site07R 11.44838 4.58111 2.499
## site09R 21.34641 11.41282 1.870
## site101 4.78380 3.19249 1.498
## site102 12.95352 6.18156 2.096
## site103 -0.01968 3.05366 -0.006
## site104 -5.49859 6.41448 -0.857
## site105 5.29599 3.19416 1.658
## site106 -5.78375 4.10816 -1.408
## site107 -1.10499 11.50670 -0.096
## site108 6.07333 9.63981 0.630
## site10R 9.77042 17.07084 0.572
## site11R 8.87343 7.29804 1.216
## site12R 7.49981 11.30952 0.663
## site13R 18.02763 8.59679 2.097
## site14R 7.14016 14.67828 0.486
## site15R -34.27578 16.20595 -2.115
## site16R -8.57692 7.30477 -1.174
## site17R 8.82432 16.34374 0.540
## site18R -5.82527 11.71301 -0.497
## site19R 3.91666 8.23086 0.476
## site20R 1.16636 6.73743 0.173
## site21R 1.16060 15.72927 0.074
## site22R -1.70705 5.23106 -0.326
## site23R -17.03062 9.44561 -1.803
## site24R 5.17213 6.14165 0.842
## site25R 0.97733 6.75491 0.145
## site28R 3.88557 9.44253 0.411
## site29R -5.01670 16.08038 -0.312
## site31R 6.16877 7.24396 0.852
## site32R 1.75911 10.68137 0.165
## site33R -18.59459 9.00705 -2.064
## site34R 0.75773 6.16849 0.123
## site35R 0.65485 9.45190 0.069
## site36R -11.83735 7.24974 -1.633
## site37R 16.09642 8.09623 1.988
## site38R 12.75212 5.43718 2.345
## site39R 23.58753 16.24004 1.452
## site40R 23.80204 11.42613 2.083
## site41R -2.95982 9.36002 -0.316
## site42R -0.28359 5.11779 -0.055
## time_firstPFT:Soil_5yrPreCensor 0.93984 2.10885 0.446
## time_firstPFT:disadv -0.02498 1.10807 -0.023
## time_firstPFT:dich_RaceNon-White 0.03690 1.12137 0.033
## time_firstPFT:sexF 0.01038 0.66049 0.016
## time_firstPFT:age_dx -0.06090 0.03462 -1.759
## time_firstPFT:smokeHxFormer 0.58001 0.67512 0.859
## time_firstPFT:smokeHxAlways 1.44836 5.29943 0.273
## time_firstPFT:smokeHxUnknown 1.59069 1.68255 0.945
## time_firstPFT:site02R -14.30199 14.76452 -0.969
## time_firstPFT:site03R 2.29376 5.24534 0.437
## time_firstPFT:site04R -4.64098 5.58521 -0.831
## time_firstPFT:site05R -0.40712 6.25177 -0.065
## time_firstPFT:site07R -3.39793 1.44092 -2.358
## time_firstPFT:site09R -6.16533 4.31210 -1.430
## time_firstPFT:site101 -0.46420 1.10811 -0.419
## time_firstPFT:site102 -2.55437 2.14671 -1.190
## time_firstPFT:site103 2.37719 1.14257 2.081
## time_firstPFT:site104 7.12352 3.57031 1.995
## time_firstPFT:site105 -0.12687 1.13135 -0.112
## time_firstPFT:site106 2.70924 1.63302 1.659
## time_firstPFT:site107 7.94497 6.73850 1.179
## time_firstPFT:site108 6.76638 3.30431 2.048
## time_firstPFT:site11R 3.63756 2.87100 1.267
## time_firstPFT:site12R 0.18900 4.16700 0.045
## time_firstPFT:site13R -1.08057 4.10803 -0.263
## time_firstPFT:site14R 3.83758 18.95751 0.202
## time_firstPFT:site15R -2.70456 11.40191 -0.237
## time_firstPFT:site16R 2.21151 2.71734 0.814
## time_firstPFT:site18R 6.53275 10.86418 0.601
## time_firstPFT:site19R 3.74727 4.68316 0.800
## time_firstPFT:site20R 1.59050 3.22706 0.493
## time_firstPFT:site21R 4.33246 4.58967 0.944
## time_firstPFT:site22R -2.40506 2.74790 -0.875
## time_firstPFT:site23R 9.36508 24.74138 0.379
## time_firstPFT:site24R 0.11427 2.33937 0.049
## time_firstPFT:site25R -5.52846 2.79434 -1.978
## time_firstPFT:site28R -9.52720 11.08131 -0.860
## time_firstPFT:site29R 0.28664 4.82384 0.059
## time_firstPFT:site31R 1.01653 2.03506 0.500
## time_firstPFT:site32R -4.92635 4.71096 -1.046
## time_firstPFT:site33R 3.12868 4.13232 0.757
## time_firstPFT:site34R -0.20968 2.39830 -0.087
## time_firstPFT:site35R 12.76888 4.21039 3.033
## time_firstPFT:site36R 3.55454 2.88184 1.233
## time_firstPFT:site37R -1.48206 2.85756 -0.519
## time_firstPFT:site38R -2.73575 1.86886 -1.464
## time_firstPFT:site39R -46.64174 8.65643 -5.388
## time_firstPFT:site40R 1.04527 4.56262 0.229
## time_firstPFT:site41R 2.00926 5.56493 0.361
## time_firstPFT:site42R 2.32288 5.40785 0.430##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(FVC_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.920
## Unadjusted ICC: 0.692report(FVC_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict fvc_pct with time_firstPFT (formula: fvc_pct ~ 1 + time_firstPFT *
## Soil_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.94) and the part related
## to the fixed effects alone (marginal R2) is of 0.25. The model's intercept,
## corresponding to time_firstPFT = 0, is at 29.88 (95% CI [17.39, 42.37], t(2038)
## = 4.69, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## Soil_5yrPreCensor (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to
## Soil_5yrPreCensor = 0, is at 29.88 (95% CI [17.39, 42.37], t(2038) = 4.69, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## disadv (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to disadv = 0,
## is at 29.88 (95% CI [17.39, 42.37], t(2038) = 4.69, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## dich_Race (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to dich_Race =
## White, is at 29.88 (95% CI [17.39, 42.37], t(2038) = 4.69, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## sex (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to sex = M, is at 29.88 (95% CI [17.39,
## 42.37], t(2038) = 4.69, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## age_dx (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to age_dx = 0,
## is at 29.88 (95% CI [17.39, 42.37], t(2038) = 4.69, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## smokeHx (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to smokeHx =
## Never, is at 29.88 (95% CI [17.39, 42.37], t(2038) = 4.69, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict fvc_pct with
## site (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.94)
## and the part related to the fixed effects alone (marginal R2) is of 0.25. The
## model's intercept, corresponding to site = Simmons, is at 29.88 (95% CI [17.39,
## 42.37], t(2038) = 4.69, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict fvc_pct
## with cohort (formula: fvc_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.94) and the part related to the fixed effects alone
## (marginal R2) is of 0.25. The model's intercept, corresponding to cohort =
## CARE-PF, is at 29.88 (95% CI [17.39, 42.37], t(2038) = 4.69, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -1.71, 95% CI [-6.40, 2.98], t(2038) = -0.72, p = 0.474; Std. beta =
## -0.53, 95% CI [-0.69, -0.36])
## - The effect of Soil 5yrPreCensor is statistically non-significant and positive
## (beta = 5.49, 95% CI [-4.48, 15.46], t(2038) = 1.08, p = 0.280; Std. beta =
## 0.10, 95% CI [-0.06, 0.25])
## - The effect of disadv is statistically non-significant and positive (beta =
## 3.90, 95% CI [-1.75, 9.56], t(2038) = 1.35, p = 0.176; Std. beta = 0.06, 95% CI
## [-0.04, 0.17])
## - The effect of dich Race [Non-White] is statistically significant and negative
## (beta = -7.68, 95% CI [-13.19, -2.18], t(2038) = -2.74, p = 0.006; Std. beta =
## -0.45, 95% CI [-0.80, -0.10])
## - The effect of sex [F] is statistically significant and positive (beta = 3.73,
## 95% CI [0.31, 7.15], t(2038) = 2.14, p = 0.033; Std. beta = 0.22, 95% CI
## [3.46e-03, 0.44])
## - The effect of age dx is statistically significant and positive (beta = 0.38,
## 95% CI [0.20, 0.56], t(2038) = 4.17, p < .001; Std. beta = 0.16, 95% CI [0.05,
## 0.26])
## - The effect of smokeHx [Former] is statistically significant and positive
## (beta = 3.64, 95% CI [0.25, 7.03], t(2038) = 2.11, p = 0.035; Std. beta = 0.27,
## 95% CI [0.05, 0.48])
## - The effect of smokeHx [Always] is statistically significant and positive
## (beta = 18.51, 95% CI [2.02, 35.01], t(2038) = 2.20, p = 0.028; Std. beta =
## 1.22, 95% CI [0.01, 2.43])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.61, 95% CI [-10.31, 5.10], t(2038) = -0.66, p = 0.507; Std. beta =
## -0.01, 95% CI [-0.52, 0.50])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.13, 95% CI [-42.85, 20.60], t(2038) = -0.69, p = 0.492; Std. beta =
## -1.94, 95% CI [-4.71, 0.84])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 8.85, 95% CI [-14.68, 32.39], t(2038) = 0.74, p = 0.461; Std. beta = 0.73,
## 95% CI [-0.72, 2.18])
## - The effect of site [04R] is statistically non-significant and positive (beta
## = 2.45, 95% CI [-19.64, 24.54], t(2038) = 0.22, p = 0.828; Std. beta = -0.27,
## 95% CI [-1.76, 1.22])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.23, 95% CI [-30.58, 6.12], t(2038) = -1.31, p = 0.191; Std. beta = -0.76,
## 95% CI [-2.12, 0.61])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 9.46, 95% CI [-22.26, 41.18], t(2038) = 0.59, p = 0.559; Std. beta = 0.56,
## 95% CI [-1.31, 2.43])
## - The effect of site [07R] is statistically significant and positive (beta =
## 11.45, 95% CI [2.46, 20.43], t(2038) = 2.50, p = 0.013; Std. beta = 0.37, 95%
## CI [-0.18, 0.92])
## - The effect of site [09R] is statistically non-significant and positive (beta
## = 21.35, 95% CI [-1.04, 43.73], t(2038) = 1.87, p = 0.062; Std. beta = 0.71,
## 95% CI [-0.73, 2.15])
## - The effect of site [101] is statistically non-significant and positive (beta
## = 4.78, 95% CI [-1.48, 11.04], t(2038) = 1.50, p = 0.134; Std. beta = 0.24, 95%
## CI [-0.15, 0.63])
## - The effect of site [102] is statistically significant and positive (beta =
## 12.95, 95% CI [0.83, 25.08], t(2038) = 2.10, p = 0.036; Std. beta = 0.54, 95%
## CI [-0.21, 1.29])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-6.01, 5.97], t(2038) = -6.45e-03, p = 0.995; Std. beta =
## 0.21, 95% CI [-0.17, 0.59])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-18.08, 7.08], t(2038) = -0.86, p = 0.391; Std. beta = 0.31,
## 95% CI [-0.59, 1.21])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-0.97, 11.56], t(2038) = 1.66, p = 0.097; Std. beta = 0.30, 95%
## CI [-0.09, 0.69])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.78, 95% CI [-13.84, 2.27], t(2038) = -1.41, p = 0.159; Std. beta = -0.10,
## 95% CI [-0.60, 0.40])
## - The effect of site [107] is statistically non-significant and negative (beta
## = -1.10, 95% CI [-23.67, 21.46], t(2038) = -0.10, p = 0.924; Std. beta = 0.65,
## 95% CI [-0.92, 2.21])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 6.07, 95% CI [-12.83, 24.98], t(2038) = 0.63, p = 0.529; Std. beta = 0.96,
## 95% CI [-0.20, 2.13])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 9.77, 95% CI [-23.71, 43.25], t(2038) = 0.57, p = 0.567; Std. beta = 0.58,
## 95% CI [-1.40, 2.55])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-5.44, 23.19], t(2038) = 1.22, p = 0.224; Std. beta = 0.85, 95%
## CI [-0.07, 1.77])
## - The effect of site [12R] is statistically non-significant and positive (beta
## = 7.50, 95% CI [-14.68, 29.68], t(2038) = 0.66, p = 0.507; Std. beta = 0.46,
## 95% CI [-0.97, 1.89])
## - The effect of site [13R] is statistically significant and positive (beta =
## 18.03, 95% CI [1.17, 34.89], t(2038) = 2.10, p = 0.036; Std. beta = 0.97, 95%
## CI [-0.09, 2.02])
## - The effect of site [14R] is statistically non-significant and positive (beta
## = 7.14, 95% CI [-21.65, 35.93], t(2038) = 0.49, p = 0.627; Std. beta = 0.76,
## 95% CI [-1.85, 3.38])
## - The effect of site [15R] is statistically significant and negative (beta =
## -34.28, 95% CI [-66.06, -2.49], t(2038) = -2.12, p = 0.035; Std. beta = -2.26,
## 95% CI [-4.62, 0.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.58, 95% CI [-22.90, 5.75], t(2038) = -1.17, p = 0.240; Std. beta = -0.31,
## 95% CI [-1.23, 0.61])
## - The effect of site [17R] is statistically non-significant and positive (beta
## = 8.82, 95% CI [-23.23, 40.88], t(2038) = 0.54, p = 0.589; Std. beta = 0.52,
## 95% CI [-1.37, 2.41])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-28.80, 17.15], t(2038) = -0.50, p = 0.619; Std. beta = 0.24,
## 95% CI [-1.89, 2.37])
## - The effect of site [19R] is statistically non-significant and positive (beta
## = 3.92, 95% CI [-12.23, 20.06], t(2038) = 0.48, p = 0.634; Std. beta = 0.57,
## 95% CI [-0.58, 1.71])
## - The effect of site [20R] is statistically non-significant and positive (beta
## = 1.17, 95% CI [-12.05, 14.38], t(2038) = 0.17, p = 0.863; Std. beta = 0.21,
## 95% CI [-0.67, 1.09])
## - The effect of site [21R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-29.69, 32.01], t(2038) = 0.07, p = 0.941; Std. beta = 0.46,
## 95% CI [-1.41, 2.33])
## - The effect of site [22R] is statistically non-significant and negative (beta
## = -1.71, 95% CI [-11.97, 8.55], t(2038) = -0.33, p = 0.744; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [23R] is statistically non-significant and negative (beta
## = -17.03, 95% CI [-35.55, 1.49], t(2038) = -1.80, p = 0.072; Std. beta = -0.17,
## 95% CI [-4.24, 3.91])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 5.17, 95% CI [-6.87, 17.22], t(2038) = 0.84, p = 0.400; Std. beta = 0.32, 95%
## CI [-0.44, 1.07])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.98, 95% CI [-12.27, 14.22], t(2038) = 0.14, p = 0.885; Std. beta = -0.44,
## 95% CI [-1.28, 0.40])
## - The effect of site [28R] is statistically non-significant and positive (beta
## = 3.89, 95% CI [-14.63, 22.40], t(2038) = 0.41, p = 0.681; Std. beta = -0.62,
## 95% CI [-2.71, 1.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-36.55, 26.52], t(2038) = -0.31, p = 0.755; Std. beta = -0.27,
## 95% CI [-2.15, 1.61])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 6.17, 95% CI [-8.04, 20.38], t(2038) = 0.85, p = 0.395; Std. beta = 0.45, 95%
## CI [-0.41, 1.32])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-19.19, 22.71], t(2038) = 0.16, p = 0.869; Std. beta = -0.34,
## 95% CI [-1.73, 1.05])
## - The effect of site [33R] is statistically significant and negative (beta =
## -18.59, 95% CI [-36.26, -0.93], t(2038) = -2.06, p = 0.039; Std. beta = -0.82,
## 95% CI [-2.00, 0.37])
## - The effect of site [34R] is statistically non-significant and positive (beta
## = 0.76, 95% CI [-11.34, 12.85], t(2038) = 0.12, p = 0.902; Std. beta = 0.03,
## 95% CI [-0.74, 0.79])
## - The effect of site [35R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.88, 19.19], t(2038) = 0.07, p = 0.945; Std. beta = 1.18,
## 95% CI [-0.01, 2.38])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -11.84, 95% CI [-26.06, 2.38], t(2038) = -1.63, p = 0.103; Std. beta = -0.38,
## 95% CI [-1.30, 0.54])
## - The effect of site [37R] is statistically significant and positive (beta =
## 16.10, 95% CI [0.22, 31.97], t(2038) = 1.99, p = 0.047; Std. beta = 0.82, 95%
## CI [-0.17, 1.80])
## - The effect of site [38R] is statistically significant and positive (beta =
## 12.75, 95% CI [2.09, 23.42], t(2038) = 2.35, p = 0.019; Std. beta = 0.51, 95%
## CI [-0.15, 1.17])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 23.59, 95% CI [-8.26, 55.44], t(2038) = 1.45, p = 0.147; Std. beta = -2.78,
## 95% CI [-4.93, -0.64])
## - The effect of site [40R] is statistically significant and positive (beta =
## 23.80, 95% CI [1.39, 46.21], t(2038) = 2.08, p = 0.037; Std. beta = 1.50, 95%
## CI [0.03, 2.97])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -2.96, 95% CI [-21.32, 15.40], t(2038) = -0.32, p = 0.752; Std. beta =
## 5.29e-03, 95% CI [-1.30, 1.31])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-10.32, 9.75], t(2038) = -0.06, p = 0.956; Std. beta = 0.19,
## 95% CI [-0.77, 1.16])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 0.94, 95% CI [-3.20, 5.08], t(2038) =
## 0.45, p = 0.656; Std. beta = 0.02, 95% CI [-0.08, 0.13])
## - The effect of time firstPFT × disadv is statistically non-significant and
## negative (beta = -0.02, 95% CI [-2.20, 2.15], t(2038) = -0.02, p = 0.982; Std.
## beta = -7.65e-04, 95% CI [-0.07, 0.07])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and positive (beta = 0.04, 95% CI [-2.16, 2.24], t(2038) =
## 0.03, p = 0.974; Std. beta = 3.97e-03, 95% CI [-0.23, 0.24])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.01, 95% CI [-1.28, 1.31], t(2038) = 0.02, p = 0.987; Std.
## beta = 1.12e-03, 95% CI [-0.14, 0.14])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.06, 95% CI [-0.13, 6.99e-03], t(2038) = -1.76, p = 0.079;
## Std. beta = -0.06, 95% CI [-0.13, 6.94e-03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.74, 1.90], t(2038) =
## 0.86, p = 0.390; Std. beta = 0.06, 95% CI [-0.08, 0.21])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and positive (beta = 1.45, 95% CI [-8.94, 11.84], t(2038) =
## 0.27, p = 0.785; Std. beta = 0.16, 95% CI [-0.96, 1.28])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.59, 95% CI [-1.71, 4.89], t(2038) =
## 0.95, p = 0.345; Std. beta = 0.17, 95% CI [-0.18, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -14.30, 95% CI [-43.26, 14.65], t(2038) = -0.97, p = 0.333;
## Std. beta = -1.54, 95% CI [-4.66, 1.58])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 2.29, 95% CI [-7.99, 12.58], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.25, 95% CI [-0.86, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.64, 95% CI [-15.59, 6.31], t(2038) = -0.83, p = 0.406; Std.
## beta = -0.50, 95% CI [-1.68, 0.68])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-12.67, 11.85], t(2038) = -0.07, p = 0.948;
## Std. beta = -0.04, 95% CI [-1.36, 1.28])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.40, 95% CI [-6.22, -0.57], t(2038) = -2.36, p = 0.018; Std.
## beta = -0.37, 95% CI [-0.67, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## negative (beta = -6.17, 95% CI [-14.62, 2.29], t(2038) = -1.43, p = 0.153; Std.
## beta = -0.66, 95% CI [-1.57, 0.25])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-2.64, 1.71], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-6.76, 1.66], t(2038) = -1.19, p = 0.234; Std.
## beta = -0.28, 95% CI [-0.73, 0.18])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.38, 95% CI [0.14, 4.62], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.26, 95% CI [0.01, 0.50])
## - The effect of time firstPFT × site [104] is statistically significant and
## positive (beta = 7.12, 95% CI [0.12, 14.13], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.77, 95% CI [0.01, 1.52])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-2.35, 2.09], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.01, 95% CI [-0.25, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.71, 95% CI [-0.49, 5.91], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.29, 95% CI [-0.05, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## positive (beta = 7.94, 95% CI [-5.27, 21.16], t(2038) = 1.18, p = 0.239; Std.
## beta = 0.86, 95% CI [-0.57, 2.28])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 6.77, 95% CI [0.29, 13.25], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.73, 95% CI [0.03, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 3.64, 95% CI [-1.99, 9.27], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.39, 95% CI [-0.21, 1.00])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.19, 95% CI [-7.98, 8.36], t(2038) = 0.05, p = 0.964; Std.
## beta = 0.02, 95% CI [-0.86, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-9.14, 6.98], t(2038) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.98, 0.75])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## positive (beta = 3.84, 95% CI [-33.34, 41.02], t(2038) = 0.20, p = 0.840; Std.
## beta = 0.41, 95% CI [-3.59, 4.42])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.70, 95% CI [-25.07, 19.66], t(2038) = -0.24, p = 0.813;
## Std. beta = -0.29, 95% CI [-2.70, 2.12])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-3.12, 7.54], t(2038) = 0.81, p = 0.416; Std.
## beta = 0.24, 95% CI [-0.34, 0.81])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## positive (beta = 6.53, 95% CI [-14.77, 27.84], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.70, 95% CI [-1.59, 3.00])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.75, 95% CI [-5.44, 12.93], t(2038) = 0.80, p = 0.424; Std.
## beta = 0.40, 95% CI [-0.59, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-4.74, 7.92], t(2038) = 0.49, p = 0.622; Std.
## beta = 0.17, 95% CI [-0.51, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.33, 95% CI [-4.67, 13.33], t(2038) = 0.94, p = 0.345; Std.
## beta = 0.47, 95% CI [-0.50, 1.44])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-7.79, 2.98], t(2038) = -0.88, p = 0.382; Std.
## beta = -0.26, 95% CI [-0.84, 0.32])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 9.37, 95% CI [-39.16, 57.89], t(2038) = 0.38, p = 0.705; Std.
## beta = 1.01, 95% CI [-4.22, 6.23])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-4.47, 4.70], t(2038) = 0.05, p = 0.961; Std.
## beta = 0.01, 95% CI [-0.48, 0.51])
## - The effect of time firstPFT × site [25R] is statistically significant and
## negative (beta = -5.53, 95% CI [-11.01, -0.05], t(2038) = -1.98, p = 0.048;
## Std. beta = -0.60, 95% CI [-1.19, -5.21e-03])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.53, 95% CI [-31.26, 12.20], t(2038) = -0.86, p = 0.390;
## Std. beta = -1.03, 95% CI [-3.37, 1.31])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.29, 95% CI [-9.17, 9.75], t(2038) = 0.06, p = 0.953; Std.
## beta = 0.03, 95% CI [-0.99, 1.05])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.97, 5.01], t(2038) = 0.50, p = 0.617; Std.
## beta = 0.11, 95% CI [-0.32, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-14.17, 4.31], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.53, 95% CI [-1.53, 0.46])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## positive (beta = 3.13, 95% CI [-4.98, 11.23], t(2038) = 0.76, p = 0.449; Std.
## beta = 0.34, 95% CI [-0.54, 1.21])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-4.91, 4.49], t(2038) = -0.09, p = 0.930; Std.
## beta = -0.02, 95% CI [-0.53, 0.48])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 12.77, 95% CI [4.51, 21.03], t(2038) = 3.03, p = 0.002; Std.
## beta = 1.38, 95% CI [0.49, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.55, 95% CI [-2.10, 9.21], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.38, 95% CI [-0.23, 0.99])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.09, 4.12], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.76, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-6.40, 0.93], t(2038) = -1.46, p = 0.143; Std.
## beta = -0.29, 95% CI [-0.69, 0.10])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -46.64, 95% CI [-63.62, -29.67], t(2038) = -5.39, p < .001;
## Std. beta = -5.02, 95% CI [-6.85, -3.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.05, 95% CI [-7.90, 9.99], t(2038) = 0.23, p = 0.819; Std.
## beta = 0.11, 95% CI [-0.85, 1.08])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-8.90, 12.92], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.22, 95% CI [-0.96, 1.39])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-8.28, 12.93], t(2038) = 0.43, p = 0.668; Std.
## beta = 0.25, 95% CI [-0.89, 1.39])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.Linear mixed models with random intercept and slope will be used to evaluate the impact of PM During Disease on DLCO decline.
DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*PM_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14856.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1486 -0.4953 -0.0042 0.4378 7.1054
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 143.79 11.991
## time_firstPFT 10.51 3.243 -0.29
## Residual 41.73 6.460
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 44.2943 4.2853 10.336
## time_firstPFT -9.6630 2.1687 -4.456
## PM_5yrPreDx -0.3120 0.3405 -0.916
## site02R -3.0799 13.6534 -0.226
## site03R 23.9608 10.0302 2.389
## site04R -5.9391 9.3006 -0.639
## site05R -12.7518 7.7735 -1.640
## site06R 4.2929 9.7050 0.442
## site07R 4.4205 3.8918 1.136
## site09R -9.5286 9.5151 -1.001
## site101 18.6533 3.0843 6.048
## site102 6.9666 5.4707 1.273
## site103 -3.7614 3.1478 -1.195
## site104 -11.5876 5.7671 -2.009
## site105 0.4881 2.8933 0.169
## site106 -4.8754 3.6408 -1.339
## site107 9.5603 9.6825 0.987
## site108 -9.9109 7.9501 -1.247
## site10R 1.3013 13.5027 0.096
## site11R 2.2028 6.4675 0.341
## site12R -10.0565 9.4652 -1.062
## site13R -10.8983 7.3963 -1.473
## site14R -7.5534 15.0441 -0.502
## site15R -23.5737 13.6593 -1.726
## site16R -8.7354 5.9130 -1.477
## site17R 58.6911 13.6923 4.286
## site18R -5.6267 9.7183 -0.579
## site19R -7.7896 6.0263 -1.293
## site20R -3.6960 5.6810 -0.651
## site21R -12.9966 12.7448 -1.020
## site22R -11.7199 4.3545 -2.691
## site23R -19.6069 6.2208 -3.152
## site24R 1.2621 5.1917 0.243
## site25R -6.9597 5.6688 -1.228
## site28R -16.9606 7.9205 -2.141
## site29R -0.4255 13.3971 -0.032
## site31R -0.9277 5.9437 -0.156
## site32R 4.2378 6.8195 0.621
## site33R -9.3090 6.7082 -1.388
## site34R -5.9574 5.2414 -1.137
## site35R -15.1364 8.1027 -1.868
## site36R 3.3556 5.9807 0.561
## site37R 1.5183 6.5465 0.232
## site38R -2.2028 4.5295 -0.486
## site39R 4.8223 13.4820 0.358
## site40R 1.2545 9.3229 0.135
## site41R -14.2959 7.8239 -1.827
## site42R -9.1016 4.3925 -2.072
## time_firstPFT:PM_5yrPreDx 0.4149 0.1664 2.493
## time_firstPFT:site02R -33.0531 18.5202 -1.785
## time_firstPFT:site03R 0.9372 5.9720 0.157
## time_firstPFT:site04R -0.7243 6.2349 -0.116
## time_firstPFT:site05R -3.1488 7.5338 -0.418
## time_firstPFT:site06R 3.9967 5.0074 0.798
## time_firstPFT:site07R -0.9505 1.5491 -0.614
## time_firstPFT:site09R 2.3958 4.1961 0.571
## time_firstPFT:site101 1.2374 1.3904 0.890
## time_firstPFT:site102 1.2554 2.4205 0.519
## time_firstPFT:site103 4.1021 1.4901 2.753
## time_firstPFT:site104 5.4799 3.8947 1.407
## time_firstPFT:site105 1.5987 1.2818 1.247
## time_firstPFT:site106 3.2513 1.7709 1.836
## time_firstPFT:site107 -11.6934 8.1643 -1.432
## time_firstPFT:site108 7.0853 3.6080 1.964
## time_firstPFT:site11R 6.0580 2.7975 2.166
## time_firstPFT:site12R 2.6480 3.9787 0.666
## time_firstPFT:site13R 0.9837 3.9472 0.249
## time_firstPFT:site14R -9.3116 23.6800 -0.393
## time_firstPFT:site15R -1.5309 14.1253 -0.108
## time_firstPFT:site16R 0.1160 2.6380 0.044
## time_firstPFT:site18R -9.3970 12.9768 -0.724
## time_firstPFT:site19R 3.7323 3.4524 1.081
## time_firstPFT:site20R 2.5197 3.4343 0.734
## time_firstPFT:site21R 6.1378 4.6947 1.307
## time_firstPFT:site22R 5.4545 2.7860 1.958
## time_firstPFT:site23R 0.6428 5.3804 0.119
## time_firstPFT:site24R -1.6503 2.5607 -0.644
## time_firstPFT:site25R -0.2928 3.0413 -0.096
## time_firstPFT:site28R -9.0944 13.0637 -0.696
## time_firstPFT:site29R -1.1694 5.0715 -0.231
## time_firstPFT:site31R 3.0404 2.0610 1.475
## time_firstPFT:site32R 0.1443 3.5616 0.041
## time_firstPFT:site33R -1.7854 3.7514 -0.476
## time_firstPFT:site34R 2.8668 2.4757 1.158
## time_firstPFT:site35R 11.1966 4.7200 2.372
## time_firstPFT:site36R 5.5003 2.9220 1.882
## time_firstPFT:site37R -0.6833 2.8330 -0.241
## time_firstPFT:site38R -0.7645 1.9506 -0.392
## time_firstPFT:site39R -27.4023 10.4590 -2.620
## time_firstPFT:site40R 3.9864 4.5923 0.868
## time_firstPFT:site41R 5.2124 6.6655 0.782
## time_firstPFT:site42R -1.9263 5.9404 -0.324##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.792
## Unadjusted ICC: 0.546report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## PM_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.31. The model's
## intercept, corresponding to time_firstPFT = 0, is at 44.29 (95% CI [35.89,
## 52.70], t(2038) = 10.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -9.66, 95% CI [-13.92, -5.41], t(2038) = -4.46, p < .001; Std. beta = -0.61,
## 95% CI [-0.75, -0.46])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.31, 95% CI [-0.98, 0.36], t(2038) = -0.92, p = 0.360; Std. beta = 0.06,
## 95% CI [-0.09, 0.21])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.08, 95% CI [-29.86, 23.70], t(2038) = -0.23, p = 0.822; Std. beta = -3.41,
## 95% CI [-6.63, -0.19])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.96, 95% CI [4.29, 43.63], t(2038) = 2.39, p = 0.017; Std. beta = 1.71, 95%
## CI [0.45, 2.97])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-24.18, 12.30], t(2038) = -0.64, p = 0.523; Std. beta = -0.47,
## 95% CI [-1.87, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-28.00, 2.49], t(2038) = -1.64, p = 0.101; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-14.74, 23.33], t(2038) = 0.44, p = 0.658; Std. beta = 0.68,
## 95% CI [-0.66, 2.02])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.42, 95% CI [-3.21, 12.05], t(2038) = 1.14, p = 0.256; Std. beta = 0.21, 95%
## CI [-0.29, 0.70])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.53, 95% CI [-28.19, 9.13], t(2038) = -1.00, p = 0.317; Std. beta = -0.41,
## 95% CI [-1.67, 0.85])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.65, 95% CI [12.60, 24.70], t(2038) = 6.05, p < .001; Std. beta = 1.38, 95%
## CI [0.97, 1.79])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.97, 95% CI [-3.76, 17.70], t(2038) = 1.27, p = 0.203; Std. beta = 0.59, 95%
## CI [-0.12, 1.30])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-9.93, 2.41], t(2038) = -1.19, p = 0.232; Std. beta = 0.14,
## 95% CI [-0.28, 0.57])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.59, 95% CI [-22.90, -0.28], t(2038) = -2.01, p = 0.045; Std. beta = -0.25,
## 95% CI [-1.15, 0.65])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.49, 95% CI [-5.19, 6.16], t(2038) = 0.17, p = 0.866; Std. beta = 0.19, 95%
## CI [-0.19, 0.57])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-12.02, 2.26], t(2038) = -1.34, p = 0.181; Std. beta = -0.01,
## 95% CI [-0.49, 0.46])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.56, 95% CI [-9.43, 28.55], t(2038) = 0.99, p = 0.324; Std. beta = -0.49,
## 95% CI [-2.06, 1.08])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-25.50, 5.68], t(2038) = -1.25, p = 0.213; Std. beta = 0.02,
## 95% CI [-1.00, 1.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.30, 95% CI [-25.18, 27.78], t(2038) = 0.10, p = 0.923; Std. beta = 0.09,
## 95% CI [-1.70, 1.88])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-10.48, 14.89], t(2038) = 0.34, p = 0.733; Std. beta = 0.74,
## 95% CI [-0.11, 1.59])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.06, 95% CI [-28.62, 8.51], t(2038) = -1.06, p = 0.288; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.90, 95% CI [-25.40, 3.61], t(2038) = -1.47, p = 0.141; Std. beta = -0.64,
## 95% CI [-1.59, 0.31])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.55, 95% CI [-37.06, 21.95], t(2038) = -0.50, p = 0.616; Std. beta = -1.41,
## 95% CI [-4.59, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.57, 95% CI [-50.36, 3.21], t(2038) = -1.73, p = 0.085; Std. beta = -1.74,
## 95% CI [-4.24, 0.76])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.33, 2.86], t(2038) = -1.48, p = 0.140; Std. beta = -0.58,
## 95% CI [-1.38, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.84, 85.54], t(2038) = 4.29, p < .001; Std. beta = 3.97, 95%
## CI [2.15, 5.78])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-24.69, 13.43], t(2038) = -0.58, p = 0.563; Std. beta = -1.29,
## 95% CI [-3.69, 1.10])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-19.61, 4.03], t(2038) = -1.29, p = 0.196; Std. beta = -0.16,
## 95% CI [-1.01, 0.68])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.84, 7.45], t(2038) = -0.65, p = 0.515; Std. beta =
## -5.60e-03, 95% CI [-0.81, 0.80])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-37.99, 12.00], t(2038) = -1.02, p = 0.308; Std. beta =
## -0.28, 95% CI [-1.86, 1.29])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.72, 95% CI [-20.26, -3.18], t(2038) = -2.69, p = 0.007; Std. beta = -0.26,
## 95% CI [-0.89, 0.36])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.61, 95% CI [-31.81, -7.41], t(2038) = -3.15, p = 0.002; Std. beta = -1.26,
## 95% CI [-2.38, -0.14])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.92, 11.44], t(2038) = 0.24, p = 0.808; Std. beta = -0.07,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.96, 95% CI [-18.08, 4.16], t(2038) = -1.23, p = 0.220; Std. beta = -0.50,
## 95% CI [-1.25, 0.26])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.96, 95% CI [-32.49, -1.43], t(2038) = -2.14, p = 0.032; Std. beta = -2.03,
## 95% CI [-4.46, 0.40])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-26.70, 25.85], t(2038) = -0.03, p = 0.975; Std. beta = -0.14,
## 95% CI [-1.75, 1.47])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-12.58, 10.73], t(2038) = -0.16, p = 0.876; Std. beta = 0.23,
## 95% CI [-0.51, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-9.14, 17.61], t(2038) = 0.62, p = 0.534; Std. beta = 0.30, 95%
## CI [-0.62, 1.22])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.31, 95% CI [-22.46, 3.85], t(2038) = -1.39, p = 0.165; Std. beta = -0.80,
## 95% CI [-1.78, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-16.24, 4.32], t(2038) = -1.14, p = 0.256; Std. beta = -0.12,
## 95% CI [-0.82, 0.57])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.14, 95% CI [-31.03, 0.75], t(2038) = -1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-1.04, 1.17])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-8.37, 15.08], t(2038) = 0.56, p = 0.575; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.32, 14.36], t(2038) = 0.23, p = 0.817; Std. beta = 0.04,
## 95% CI [-0.80, 0.87])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-11.09, 6.68], t(2038) = -0.49, p = 0.627; Std. beta = -0.22,
## 95% CI [-0.81, 0.36])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.82, 95% CI [-21.62, 31.26], t(2038) = 0.36, p = 0.721; Std. beta = -2.33,
## 95% CI [-4.43, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-17.03, 19.54], t(2038) = 0.13, p = 0.893; Std. beta = 0.47,
## 95% CI [-0.83, 1.77])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.30, 95% CI [-29.64, 1.05], t(2038) = -1.83, p = 0.068; Std. beta = -0.46,
## 95% CI [-1.78, 0.86])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.10, 95% CI [-17.72, -0.49], t(2038) = -2.07, p = 0.038; Std. beta = -0.80,
## 95% CI [-1.84, 0.23])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.41, 95% CI [0.09, 0.74], t(2038) = 2.49, p = 0.013; Std.
## beta = 0.14, 95% CI [0.03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.05, 95% CI [-69.37, 3.27], t(2038) = -1.78, p = 0.074;
## Std. beta = -3.55, 95% CI [-7.46, 0.35])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-10.77, 12.65], t(2038) = 0.16, p = 0.875; Std.
## beta = 0.10, 95% CI [-1.16, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-12.95, 11.50], t(2038) = -0.12, p = 0.908;
## Std. beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-17.92, 11.63], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-5.82, 13.82], t(2038) = 0.80, p = 0.425; Std.
## beta = 0.43, 95% CI [-0.63, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-3.99, 2.09], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.10, 95% CI [-0.43, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-5.83, 10.62], t(2038) = 0.57, p = 0.568; Std.
## beta = 0.26, 95% CI [-0.63, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.49, 3.96], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.13, 95% CI [-0.16, 0.43])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.26, 95% CI [-3.49, 6.00], t(2038) = 0.52, p = 0.604; Std.
## beta = 0.13, 95% CI [-0.38, 0.65])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.10, 95% CI [1.18, 7.02], t(2038) = 2.75, p = 0.006; Std.
## beta = 0.44, 95% CI [0.13, 0.76])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-2.16, 13.12], t(2038) = 1.41, p = 0.160; Std.
## beta = 0.59, 95% CI [-0.23, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-0.92, 4.11], t(2038) = 1.25, p = 0.212; Std.
## beta = 0.17, 95% CI [-0.10, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.22, 6.72], t(2038) = 1.84, p = 0.067; Std.
## beta = 0.35, 95% CI [-0.02, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.69, 95% CI [-27.70, 4.32], t(2038) = -1.43, p = 0.152;
## Std. beta = -1.26, 95% CI [-2.98, 0.46])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.09, 95% CI [9.52e-03, 14.16], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.76, 95% CI [1.02e-03, 1.52])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.06, 95% CI [0.57, 11.54], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.65, 95% CI [0.06, 1.24])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.15, 10.45], t(2038) = 0.67, p = 0.506; Std.
## beta = 0.28, 95% CI [-0.55, 1.12])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-6.76, 8.72], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.11, 95% CI [-0.73, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.31, 95% CI [-55.75, 37.13], t(2038) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-5.99, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-29.23, 26.17], t(2038) = -0.11, p = 0.914;
## Std. beta = -0.16, 95% CI [-3.14, 2.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.12, 95% CI [-5.06, 5.29], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.01, 95% CI [-0.54, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-34.85, 16.05], t(2038) = -0.72, p = 0.469;
## Std. beta = -1.01, 95% CI [-3.75, 1.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-3.04, 10.50], t(2038) = 1.08, p = 0.280; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-4.22, 9.25], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.27, 95% CI [-0.45, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-3.07, 15.34], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.66, 95% CI [-0.33, 1.65])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-9.28e-03, 10.92], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.59, 95% CI [-9.97e-04, 1.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.64, 95% CI [-9.91, 11.19], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.07, 95% CI [-1.07, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.65, 95% CI [-6.67, 3.37], t(2038) = -0.64, p = 0.519; Std.
## beta = -0.18, 95% CI [-0.72, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-6.26, 5.67], t(2038) = -0.10, p = 0.923; Std.
## beta = -0.03, 95% CI [-0.67, 0.61])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.09, 95% CI [-34.71, 16.53], t(2038) = -0.70, p = 0.486;
## Std. beta = -0.98, 95% CI [-3.73, 1.78])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-11.12, 8.78], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.13, 95% CI [-1.19, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-1.00, 7.08], t(2038) = 1.48, p = 0.140; Std.
## beta = 0.33, 95% CI [-0.11, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-6.84, 7.13], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.74, 0.77])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.79, 95% CI [-9.14, 5.57], t(2038) = -0.48, p = 0.634; Std.
## beta = -0.19, 95% CI [-0.98, 0.60])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-1.99, 7.72], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.20, 95% CI [1.94, 20.45], t(2038) = 2.37, p = 0.018; Std.
## beta = 1.20, 95% CI [0.21, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-0.23, 11.23], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.59, 95% CI [-0.02, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-6.24, 4.87], t(2038) = -0.24, p = 0.809; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-4.59, 3.06], t(2038) = -0.39, p = 0.695; Std.
## beta = -0.08, 95% CI [-0.49, 0.33])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.40, 95% CI [-47.91, -6.89], t(2038) = -2.62, p = 0.009;
## Std. beta = -2.95, 95% CI [-5.15, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-5.02, 12.99], t(2038) = 0.87, p = 0.385; Std.
## beta = 0.43, 95% CI [-0.54, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-7.86, 18.28], t(2038) = 0.78, p = 0.434; Std.
## beta = 0.56, 95% CI [-0.84, 1.97])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-13.58, 9.72], t(2038) = -0.32, p = 0.746; Std.
## beta = -0.21, 95% CI [-1.46, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## PM_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.31. The model's intercept,
## corresponding to PM_5yrPreDx = 0, is at 44.29 (95% CI [35.89, 52.70], t(2038) =
## 10.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -9.66, 95% CI [-13.92, -5.41], t(2038) = -4.46, p < .001; Std. beta = -0.61,
## 95% CI [-0.75, -0.46])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.31, 95% CI [-0.98, 0.36], t(2038) = -0.92, p = 0.360; Std. beta = 0.06,
## 95% CI [-0.09, 0.21])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.08, 95% CI [-29.86, 23.70], t(2038) = -0.23, p = 0.822; Std. beta = -3.41,
## 95% CI [-6.63, -0.19])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.96, 95% CI [4.29, 43.63], t(2038) = 2.39, p = 0.017; Std. beta = 1.71, 95%
## CI [0.45, 2.97])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-24.18, 12.30], t(2038) = -0.64, p = 0.523; Std. beta = -0.47,
## 95% CI [-1.87, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-28.00, 2.49], t(2038) = -1.64, p = 0.101; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-14.74, 23.33], t(2038) = 0.44, p = 0.658; Std. beta = 0.68,
## 95% CI [-0.66, 2.02])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.42, 95% CI [-3.21, 12.05], t(2038) = 1.14, p = 0.256; Std. beta = 0.21, 95%
## CI [-0.29, 0.70])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.53, 95% CI [-28.19, 9.13], t(2038) = -1.00, p = 0.317; Std. beta = -0.41,
## 95% CI [-1.67, 0.85])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.65, 95% CI [12.60, 24.70], t(2038) = 6.05, p < .001; Std. beta = 1.38, 95%
## CI [0.97, 1.79])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.97, 95% CI [-3.76, 17.70], t(2038) = 1.27, p = 0.203; Std. beta = 0.59, 95%
## CI [-0.12, 1.30])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-9.93, 2.41], t(2038) = -1.19, p = 0.232; Std. beta = 0.14,
## 95% CI [-0.28, 0.57])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.59, 95% CI [-22.90, -0.28], t(2038) = -2.01, p = 0.045; Std. beta = -0.25,
## 95% CI [-1.15, 0.65])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.49, 95% CI [-5.19, 6.16], t(2038) = 0.17, p = 0.866; Std. beta = 0.19, 95%
## CI [-0.19, 0.57])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-12.02, 2.26], t(2038) = -1.34, p = 0.181; Std. beta = -0.01,
## 95% CI [-0.49, 0.46])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.56, 95% CI [-9.43, 28.55], t(2038) = 0.99, p = 0.324; Std. beta = -0.49,
## 95% CI [-2.06, 1.08])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-25.50, 5.68], t(2038) = -1.25, p = 0.213; Std. beta = 0.02,
## 95% CI [-1.00, 1.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.30, 95% CI [-25.18, 27.78], t(2038) = 0.10, p = 0.923; Std. beta = 0.09,
## 95% CI [-1.70, 1.88])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-10.48, 14.89], t(2038) = 0.34, p = 0.733; Std. beta = 0.74,
## 95% CI [-0.11, 1.59])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.06, 95% CI [-28.62, 8.51], t(2038) = -1.06, p = 0.288; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.90, 95% CI [-25.40, 3.61], t(2038) = -1.47, p = 0.141; Std. beta = -0.64,
## 95% CI [-1.59, 0.31])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.55, 95% CI [-37.06, 21.95], t(2038) = -0.50, p = 0.616; Std. beta = -1.41,
## 95% CI [-4.59, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.57, 95% CI [-50.36, 3.21], t(2038) = -1.73, p = 0.085; Std. beta = -1.74,
## 95% CI [-4.24, 0.76])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.33, 2.86], t(2038) = -1.48, p = 0.140; Std. beta = -0.58,
## 95% CI [-1.38, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.84, 85.54], t(2038) = 4.29, p < .001; Std. beta = 3.97, 95%
## CI [2.15, 5.78])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-24.69, 13.43], t(2038) = -0.58, p = 0.563; Std. beta = -1.29,
## 95% CI [-3.69, 1.10])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-19.61, 4.03], t(2038) = -1.29, p = 0.196; Std. beta = -0.16,
## 95% CI [-1.01, 0.68])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.84, 7.45], t(2038) = -0.65, p = 0.515; Std. beta =
## -5.60e-03, 95% CI [-0.81, 0.80])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-37.99, 12.00], t(2038) = -1.02, p = 0.308; Std. beta =
## -0.28, 95% CI [-1.86, 1.29])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.72, 95% CI [-20.26, -3.18], t(2038) = -2.69, p = 0.007; Std. beta = -0.26,
## 95% CI [-0.89, 0.36])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.61, 95% CI [-31.81, -7.41], t(2038) = -3.15, p = 0.002; Std. beta = -1.26,
## 95% CI [-2.38, -0.14])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.92, 11.44], t(2038) = 0.24, p = 0.808; Std. beta = -0.07,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.96, 95% CI [-18.08, 4.16], t(2038) = -1.23, p = 0.220; Std. beta = -0.50,
## 95% CI [-1.25, 0.26])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.96, 95% CI [-32.49, -1.43], t(2038) = -2.14, p = 0.032; Std. beta = -2.03,
## 95% CI [-4.46, 0.40])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-26.70, 25.85], t(2038) = -0.03, p = 0.975; Std. beta = -0.14,
## 95% CI [-1.75, 1.47])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-12.58, 10.73], t(2038) = -0.16, p = 0.876; Std. beta = 0.23,
## 95% CI [-0.51, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-9.14, 17.61], t(2038) = 0.62, p = 0.534; Std. beta = 0.30, 95%
## CI [-0.62, 1.22])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.31, 95% CI [-22.46, 3.85], t(2038) = -1.39, p = 0.165; Std. beta = -0.80,
## 95% CI [-1.78, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-16.24, 4.32], t(2038) = -1.14, p = 0.256; Std. beta = -0.12,
## 95% CI [-0.82, 0.57])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.14, 95% CI [-31.03, 0.75], t(2038) = -1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-1.04, 1.17])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-8.37, 15.08], t(2038) = 0.56, p = 0.575; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.32, 14.36], t(2038) = 0.23, p = 0.817; Std. beta = 0.04,
## 95% CI [-0.80, 0.87])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-11.09, 6.68], t(2038) = -0.49, p = 0.627; Std. beta = -0.22,
## 95% CI [-0.81, 0.36])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.82, 95% CI [-21.62, 31.26], t(2038) = 0.36, p = 0.721; Std. beta = -2.33,
## 95% CI [-4.43, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-17.03, 19.54], t(2038) = 0.13, p = 0.893; Std. beta = 0.47,
## 95% CI [-0.83, 1.77])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.30, 95% CI [-29.64, 1.05], t(2038) = -1.83, p = 0.068; Std. beta = -0.46,
## 95% CI [-1.78, 0.86])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.10, 95% CI [-17.72, -0.49], t(2038) = -2.07, p = 0.038; Std. beta = -0.80,
## 95% CI [-1.84, 0.23])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.41, 95% CI [0.09, 0.74], t(2038) = 2.49, p = 0.013; Std.
## beta = 0.14, 95% CI [0.03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.05, 95% CI [-69.37, 3.27], t(2038) = -1.78, p = 0.074;
## Std. beta = -3.55, 95% CI [-7.46, 0.35])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-10.77, 12.65], t(2038) = 0.16, p = 0.875; Std.
## beta = 0.10, 95% CI [-1.16, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-12.95, 11.50], t(2038) = -0.12, p = 0.908;
## Std. beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-17.92, 11.63], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-5.82, 13.82], t(2038) = 0.80, p = 0.425; Std.
## beta = 0.43, 95% CI [-0.63, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-3.99, 2.09], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.10, 95% CI [-0.43, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-5.83, 10.62], t(2038) = 0.57, p = 0.568; Std.
## beta = 0.26, 95% CI [-0.63, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.49, 3.96], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.13, 95% CI [-0.16, 0.43])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.26, 95% CI [-3.49, 6.00], t(2038) = 0.52, p = 0.604; Std.
## beta = 0.13, 95% CI [-0.38, 0.65])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.10, 95% CI [1.18, 7.02], t(2038) = 2.75, p = 0.006; Std.
## beta = 0.44, 95% CI [0.13, 0.76])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-2.16, 13.12], t(2038) = 1.41, p = 0.160; Std.
## beta = 0.59, 95% CI [-0.23, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-0.92, 4.11], t(2038) = 1.25, p = 0.212; Std.
## beta = 0.17, 95% CI [-0.10, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.22, 6.72], t(2038) = 1.84, p = 0.067; Std.
## beta = 0.35, 95% CI [-0.02, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.69, 95% CI [-27.70, 4.32], t(2038) = -1.43, p = 0.152;
## Std. beta = -1.26, 95% CI [-2.98, 0.46])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.09, 95% CI [9.52e-03, 14.16], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.76, 95% CI [1.02e-03, 1.52])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.06, 95% CI [0.57, 11.54], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.65, 95% CI [0.06, 1.24])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.15, 10.45], t(2038) = 0.67, p = 0.506; Std.
## beta = 0.28, 95% CI [-0.55, 1.12])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-6.76, 8.72], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.11, 95% CI [-0.73, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.31, 95% CI [-55.75, 37.13], t(2038) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-5.99, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-29.23, 26.17], t(2038) = -0.11, p = 0.914;
## Std. beta = -0.16, 95% CI [-3.14, 2.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.12, 95% CI [-5.06, 5.29], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.01, 95% CI [-0.54, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-34.85, 16.05], t(2038) = -0.72, p = 0.469;
## Std. beta = -1.01, 95% CI [-3.75, 1.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-3.04, 10.50], t(2038) = 1.08, p = 0.280; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-4.22, 9.25], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.27, 95% CI [-0.45, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-3.07, 15.34], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.66, 95% CI [-0.33, 1.65])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-9.28e-03, 10.92], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.59, 95% CI [-9.97e-04, 1.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.64, 95% CI [-9.91, 11.19], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.07, 95% CI [-1.07, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.65, 95% CI [-6.67, 3.37], t(2038) = -0.64, p = 0.519; Std.
## beta = -0.18, 95% CI [-0.72, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-6.26, 5.67], t(2038) = -0.10, p = 0.923; Std.
## beta = -0.03, 95% CI [-0.67, 0.61])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.09, 95% CI [-34.71, 16.53], t(2038) = -0.70, p = 0.486;
## Std. beta = -0.98, 95% CI [-3.73, 1.78])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-11.12, 8.78], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.13, 95% CI [-1.19, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-1.00, 7.08], t(2038) = 1.48, p = 0.140; Std.
## beta = 0.33, 95% CI [-0.11, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-6.84, 7.13], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.74, 0.77])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.79, 95% CI [-9.14, 5.57], t(2038) = -0.48, p = 0.634; Std.
## beta = -0.19, 95% CI [-0.98, 0.60])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-1.99, 7.72], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.20, 95% CI [1.94, 20.45], t(2038) = 2.37, p = 0.018; Std.
## beta = 1.20, 95% CI [0.21, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-0.23, 11.23], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.59, 95% CI [-0.02, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-6.24, 4.87], t(2038) = -0.24, p = 0.809; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-4.59, 3.06], t(2038) = -0.39, p = 0.695; Std.
## beta = -0.08, 95% CI [-0.49, 0.33])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.40, 95% CI [-47.91, -6.89], t(2038) = -2.62, p = 0.009;
## Std. beta = -2.95, 95% CI [-5.15, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-5.02, 12.99], t(2038) = 0.87, p = 0.385; Std.
## beta = 0.43, 95% CI [-0.54, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-7.86, 18.28], t(2038) = 0.78, p = 0.434; Std.
## beta = 0.56, 95% CI [-0.84, 1.97])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-13.58, 9.72], t(2038) = -0.32, p = 0.746; Std.
## beta = -0.21, 95% CI [-1.46, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.31. The model's intercept, corresponding to site =
## Simmons, is at 44.29 (95% CI [35.89, 52.70], t(2038) = 10.34, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -9.66, 95% CI [-13.92, -5.41], t(2038) = -4.46, p < .001; Std. beta = -0.61,
## 95% CI [-0.75, -0.46])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.31, 95% CI [-0.98, 0.36], t(2038) = -0.92, p = 0.360; Std. beta = 0.06,
## 95% CI [-0.09, 0.21])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.08, 95% CI [-29.86, 23.70], t(2038) = -0.23, p = 0.822; Std. beta = -3.41,
## 95% CI [-6.63, -0.19])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.96, 95% CI [4.29, 43.63], t(2038) = 2.39, p = 0.017; Std. beta = 1.71, 95%
## CI [0.45, 2.97])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-24.18, 12.30], t(2038) = -0.64, p = 0.523; Std. beta = -0.47,
## 95% CI [-1.87, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-28.00, 2.49], t(2038) = -1.64, p = 0.101; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-14.74, 23.33], t(2038) = 0.44, p = 0.658; Std. beta = 0.68,
## 95% CI [-0.66, 2.02])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.42, 95% CI [-3.21, 12.05], t(2038) = 1.14, p = 0.256; Std. beta = 0.21, 95%
## CI [-0.29, 0.70])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.53, 95% CI [-28.19, 9.13], t(2038) = -1.00, p = 0.317; Std. beta = -0.41,
## 95% CI [-1.67, 0.85])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.65, 95% CI [12.60, 24.70], t(2038) = 6.05, p < .001; Std. beta = 1.38, 95%
## CI [0.97, 1.79])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.97, 95% CI [-3.76, 17.70], t(2038) = 1.27, p = 0.203; Std. beta = 0.59, 95%
## CI [-0.12, 1.30])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-9.93, 2.41], t(2038) = -1.19, p = 0.232; Std. beta = 0.14,
## 95% CI [-0.28, 0.57])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.59, 95% CI [-22.90, -0.28], t(2038) = -2.01, p = 0.045; Std. beta = -0.25,
## 95% CI [-1.15, 0.65])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.49, 95% CI [-5.19, 6.16], t(2038) = 0.17, p = 0.866; Std. beta = 0.19, 95%
## CI [-0.19, 0.57])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-12.02, 2.26], t(2038) = -1.34, p = 0.181; Std. beta = -0.01,
## 95% CI [-0.49, 0.46])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.56, 95% CI [-9.43, 28.55], t(2038) = 0.99, p = 0.324; Std. beta = -0.49,
## 95% CI [-2.06, 1.08])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-25.50, 5.68], t(2038) = -1.25, p = 0.213; Std. beta = 0.02,
## 95% CI [-1.00, 1.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.30, 95% CI [-25.18, 27.78], t(2038) = 0.10, p = 0.923; Std. beta = 0.09,
## 95% CI [-1.70, 1.88])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-10.48, 14.89], t(2038) = 0.34, p = 0.733; Std. beta = 0.74,
## 95% CI [-0.11, 1.59])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.06, 95% CI [-28.62, 8.51], t(2038) = -1.06, p = 0.288; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.90, 95% CI [-25.40, 3.61], t(2038) = -1.47, p = 0.141; Std. beta = -0.64,
## 95% CI [-1.59, 0.31])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.55, 95% CI [-37.06, 21.95], t(2038) = -0.50, p = 0.616; Std. beta = -1.41,
## 95% CI [-4.59, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.57, 95% CI [-50.36, 3.21], t(2038) = -1.73, p = 0.085; Std. beta = -1.74,
## 95% CI [-4.24, 0.76])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.33, 2.86], t(2038) = -1.48, p = 0.140; Std. beta = -0.58,
## 95% CI [-1.38, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.84, 85.54], t(2038) = 4.29, p < .001; Std. beta = 3.97, 95%
## CI [2.15, 5.78])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-24.69, 13.43], t(2038) = -0.58, p = 0.563; Std. beta = -1.29,
## 95% CI [-3.69, 1.10])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-19.61, 4.03], t(2038) = -1.29, p = 0.196; Std. beta = -0.16,
## 95% CI [-1.01, 0.68])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.84, 7.45], t(2038) = -0.65, p = 0.515; Std. beta =
## -5.60e-03, 95% CI [-0.81, 0.80])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-37.99, 12.00], t(2038) = -1.02, p = 0.308; Std. beta =
## -0.28, 95% CI [-1.86, 1.29])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.72, 95% CI [-20.26, -3.18], t(2038) = -2.69, p = 0.007; Std. beta = -0.26,
## 95% CI [-0.89, 0.36])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.61, 95% CI [-31.81, -7.41], t(2038) = -3.15, p = 0.002; Std. beta = -1.26,
## 95% CI [-2.38, -0.14])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.92, 11.44], t(2038) = 0.24, p = 0.808; Std. beta = -0.07,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.96, 95% CI [-18.08, 4.16], t(2038) = -1.23, p = 0.220; Std. beta = -0.50,
## 95% CI [-1.25, 0.26])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.96, 95% CI [-32.49, -1.43], t(2038) = -2.14, p = 0.032; Std. beta = -2.03,
## 95% CI [-4.46, 0.40])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-26.70, 25.85], t(2038) = -0.03, p = 0.975; Std. beta = -0.14,
## 95% CI [-1.75, 1.47])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-12.58, 10.73], t(2038) = -0.16, p = 0.876; Std. beta = 0.23,
## 95% CI [-0.51, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-9.14, 17.61], t(2038) = 0.62, p = 0.534; Std. beta = 0.30, 95%
## CI [-0.62, 1.22])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.31, 95% CI [-22.46, 3.85], t(2038) = -1.39, p = 0.165; Std. beta = -0.80,
## 95% CI [-1.78, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-16.24, 4.32], t(2038) = -1.14, p = 0.256; Std. beta = -0.12,
## 95% CI [-0.82, 0.57])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.14, 95% CI [-31.03, 0.75], t(2038) = -1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-1.04, 1.17])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-8.37, 15.08], t(2038) = 0.56, p = 0.575; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.32, 14.36], t(2038) = 0.23, p = 0.817; Std. beta = 0.04,
## 95% CI [-0.80, 0.87])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-11.09, 6.68], t(2038) = -0.49, p = 0.627; Std. beta = -0.22,
## 95% CI [-0.81, 0.36])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.82, 95% CI [-21.62, 31.26], t(2038) = 0.36, p = 0.721; Std. beta = -2.33,
## 95% CI [-4.43, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-17.03, 19.54], t(2038) = 0.13, p = 0.893; Std. beta = 0.47,
## 95% CI [-0.83, 1.77])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.30, 95% CI [-29.64, 1.05], t(2038) = -1.83, p = 0.068; Std. beta = -0.46,
## 95% CI [-1.78, 0.86])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.10, 95% CI [-17.72, -0.49], t(2038) = -2.07, p = 0.038; Std. beta = -0.80,
## 95% CI [-1.84, 0.23])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.41, 95% CI [0.09, 0.74], t(2038) = 2.49, p = 0.013; Std.
## beta = 0.14, 95% CI [0.03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.05, 95% CI [-69.37, 3.27], t(2038) = -1.78, p = 0.074;
## Std. beta = -3.55, 95% CI [-7.46, 0.35])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-10.77, 12.65], t(2038) = 0.16, p = 0.875; Std.
## beta = 0.10, 95% CI [-1.16, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-12.95, 11.50], t(2038) = -0.12, p = 0.908;
## Std. beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-17.92, 11.63], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-5.82, 13.82], t(2038) = 0.80, p = 0.425; Std.
## beta = 0.43, 95% CI [-0.63, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-3.99, 2.09], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.10, 95% CI [-0.43, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-5.83, 10.62], t(2038) = 0.57, p = 0.568; Std.
## beta = 0.26, 95% CI [-0.63, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.49, 3.96], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.13, 95% CI [-0.16, 0.43])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.26, 95% CI [-3.49, 6.00], t(2038) = 0.52, p = 0.604; Std.
## beta = 0.13, 95% CI [-0.38, 0.65])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.10, 95% CI [1.18, 7.02], t(2038) = 2.75, p = 0.006; Std.
## beta = 0.44, 95% CI [0.13, 0.76])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-2.16, 13.12], t(2038) = 1.41, p = 0.160; Std.
## beta = 0.59, 95% CI [-0.23, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-0.92, 4.11], t(2038) = 1.25, p = 0.212; Std.
## beta = 0.17, 95% CI [-0.10, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.22, 6.72], t(2038) = 1.84, p = 0.067; Std.
## beta = 0.35, 95% CI [-0.02, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.69, 95% CI [-27.70, 4.32], t(2038) = -1.43, p = 0.152;
## Std. beta = -1.26, 95% CI [-2.98, 0.46])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.09, 95% CI [9.52e-03, 14.16], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.76, 95% CI [1.02e-03, 1.52])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.06, 95% CI [0.57, 11.54], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.65, 95% CI [0.06, 1.24])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.15, 10.45], t(2038) = 0.67, p = 0.506; Std.
## beta = 0.28, 95% CI [-0.55, 1.12])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-6.76, 8.72], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.11, 95% CI [-0.73, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.31, 95% CI [-55.75, 37.13], t(2038) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-5.99, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-29.23, 26.17], t(2038) = -0.11, p = 0.914;
## Std. beta = -0.16, 95% CI [-3.14, 2.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.12, 95% CI [-5.06, 5.29], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.01, 95% CI [-0.54, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-34.85, 16.05], t(2038) = -0.72, p = 0.469;
## Std. beta = -1.01, 95% CI [-3.75, 1.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-3.04, 10.50], t(2038) = 1.08, p = 0.280; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-4.22, 9.25], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.27, 95% CI [-0.45, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-3.07, 15.34], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.66, 95% CI [-0.33, 1.65])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-9.28e-03, 10.92], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.59, 95% CI [-9.97e-04, 1.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.64, 95% CI [-9.91, 11.19], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.07, 95% CI [-1.07, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.65, 95% CI [-6.67, 3.37], t(2038) = -0.64, p = 0.519; Std.
## beta = -0.18, 95% CI [-0.72, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-6.26, 5.67], t(2038) = -0.10, p = 0.923; Std.
## beta = -0.03, 95% CI [-0.67, 0.61])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.09, 95% CI [-34.71, 16.53], t(2038) = -0.70, p = 0.486;
## Std. beta = -0.98, 95% CI [-3.73, 1.78])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-11.12, 8.78], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.13, 95% CI [-1.19, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-1.00, 7.08], t(2038) = 1.48, p = 0.140; Std.
## beta = 0.33, 95% CI [-0.11, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-6.84, 7.13], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.74, 0.77])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.79, 95% CI [-9.14, 5.57], t(2038) = -0.48, p = 0.634; Std.
## beta = -0.19, 95% CI [-0.98, 0.60])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-1.99, 7.72], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.20, 95% CI [1.94, 20.45], t(2038) = 2.37, p = 0.018; Std.
## beta = 1.20, 95% CI [0.21, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-0.23, 11.23], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.59, 95% CI [-0.02, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-6.24, 4.87], t(2038) = -0.24, p = 0.809; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-4.59, 3.06], t(2038) = -0.39, p = 0.695; Std.
## beta = -0.08, 95% CI [-0.49, 0.33])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.40, 95% CI [-47.91, -6.89], t(2038) = -2.62, p = 0.009;
## Std. beta = -2.95, 95% CI [-5.15, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-5.02, 12.99], t(2038) = 0.87, p = 0.385; Std.
## beta = 0.43, 95% CI [-0.54, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-7.86, 18.28], t(2038) = 0.78, p = 0.434; Std.
## beta = 0.56, 95% CI [-0.84, 1.97])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-13.58, 9.72], t(2038) = -0.32, p = 0.746; Std.
## beta = -0.21, 95% CI [-1.46, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.31. The model's intercept,
## corresponding to cohort = CARE-PF, is at 44.29 (95% CI [35.89, 52.70], t(2038)
## = 10.34, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -9.66, 95% CI [-13.92, -5.41], t(2038) = -4.46, p < .001; Std. beta = -0.61,
## 95% CI [-0.75, -0.46])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.31, 95% CI [-0.98, 0.36], t(2038) = -0.92, p = 0.360; Std. beta = 0.06,
## 95% CI [-0.09, 0.21])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.08, 95% CI [-29.86, 23.70], t(2038) = -0.23, p = 0.822; Std. beta = -3.41,
## 95% CI [-6.63, -0.19])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.96, 95% CI [4.29, 43.63], t(2038) = 2.39, p = 0.017; Std. beta = 1.71, 95%
## CI [0.45, 2.97])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.94, 95% CI [-24.18, 12.30], t(2038) = -0.64, p = 0.523; Std. beta = -0.47,
## 95% CI [-1.87, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-28.00, 2.49], t(2038) = -1.64, p = 0.101; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-14.74, 23.33], t(2038) = 0.44, p = 0.658; Std. beta = 0.68,
## 95% CI [-0.66, 2.02])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.42, 95% CI [-3.21, 12.05], t(2038) = 1.14, p = 0.256; Std. beta = 0.21, 95%
## CI [-0.29, 0.70])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.53, 95% CI [-28.19, 9.13], t(2038) = -1.00, p = 0.317; Std. beta = -0.41,
## 95% CI [-1.67, 0.85])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.65, 95% CI [12.60, 24.70], t(2038) = 6.05, p < .001; Std. beta = 1.38, 95%
## CI [0.97, 1.79])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.97, 95% CI [-3.76, 17.70], t(2038) = 1.27, p = 0.203; Std. beta = 0.59, 95%
## CI [-0.12, 1.30])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-9.93, 2.41], t(2038) = -1.19, p = 0.232; Std. beta = 0.14,
## 95% CI [-0.28, 0.57])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.59, 95% CI [-22.90, -0.28], t(2038) = -2.01, p = 0.045; Std. beta = -0.25,
## 95% CI [-1.15, 0.65])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.49, 95% CI [-5.19, 6.16], t(2038) = 0.17, p = 0.866; Std. beta = 0.19, 95%
## CI [-0.19, 0.57])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.88, 95% CI [-12.02, 2.26], t(2038) = -1.34, p = 0.181; Std. beta = -0.01,
## 95% CI [-0.49, 0.46])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.56, 95% CI [-9.43, 28.55], t(2038) = 0.99, p = 0.324; Std. beta = -0.49,
## 95% CI [-2.06, 1.08])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-25.50, 5.68], t(2038) = -1.25, p = 0.213; Std. beta = 0.02,
## 95% CI [-1.00, 1.03])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.30, 95% CI [-25.18, 27.78], t(2038) = 0.10, p = 0.923; Std. beta = 0.09,
## 95% CI [-1.70, 1.88])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-10.48, 14.89], t(2038) = 0.34, p = 0.733; Std. beta = 0.74,
## 95% CI [-0.11, 1.59])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.06, 95% CI [-28.62, 8.51], t(2038) = -1.06, p = 0.288; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.90, 95% CI [-25.40, 3.61], t(2038) = -1.47, p = 0.141; Std. beta = -0.64,
## 95% CI [-1.59, 0.31])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.55, 95% CI [-37.06, 21.95], t(2038) = -0.50, p = 0.616; Std. beta = -1.41,
## 95% CI [-4.59, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.57, 95% CI [-50.36, 3.21], t(2038) = -1.73, p = 0.085; Std. beta = -1.74,
## 95% CI [-4.24, 0.76])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.33, 2.86], t(2038) = -1.48, p = 0.140; Std. beta = -0.58,
## 95% CI [-1.38, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.84, 85.54], t(2038) = 4.29, p < .001; Std. beta = 3.97, 95%
## CI [2.15, 5.78])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.63, 95% CI [-24.69, 13.43], t(2038) = -0.58, p = 0.563; Std. beta = -1.29,
## 95% CI [-3.69, 1.10])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-19.61, 4.03], t(2038) = -1.29, p = 0.196; Std. beta = -0.16,
## 95% CI [-1.01, 0.68])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.84, 7.45], t(2038) = -0.65, p = 0.515; Std. beta =
## -5.60e-03, 95% CI [-0.81, 0.80])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.00, 95% CI [-37.99, 12.00], t(2038) = -1.02, p = 0.308; Std. beta =
## -0.28, 95% CI [-1.86, 1.29])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.72, 95% CI [-20.26, -3.18], t(2038) = -2.69, p = 0.007; Std. beta = -0.26,
## 95% CI [-0.89, 0.36])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.61, 95% CI [-31.81, -7.41], t(2038) = -3.15, p = 0.002; Std. beta = -1.26,
## 95% CI [-2.38, -0.14])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.92, 11.44], t(2038) = 0.24, p = 0.808; Std. beta = -0.07,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.96, 95% CI [-18.08, 4.16], t(2038) = -1.23, p = 0.220; Std. beta = -0.50,
## 95% CI [-1.25, 0.26])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.96, 95% CI [-32.49, -1.43], t(2038) = -2.14, p = 0.032; Std. beta = -2.03,
## 95% CI [-4.46, 0.40])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-26.70, 25.85], t(2038) = -0.03, p = 0.975; Std. beta = -0.14,
## 95% CI [-1.75, 1.47])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-12.58, 10.73], t(2038) = -0.16, p = 0.876; Std. beta = 0.23,
## 95% CI [-0.51, 0.97])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.24, 95% CI [-9.14, 17.61], t(2038) = 0.62, p = 0.534; Std. beta = 0.30, 95%
## CI [-0.62, 1.22])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.31, 95% CI [-22.46, 3.85], t(2038) = -1.39, p = 0.165; Std. beta = -0.80,
## 95% CI [-1.78, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-16.24, 4.32], t(2038) = -1.14, p = 0.256; Std. beta = -0.12,
## 95% CI [-0.82, 0.57])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.14, 95% CI [-31.03, 0.75], t(2038) = -1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-1.04, 1.17])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-8.37, 15.08], t(2038) = 0.56, p = 0.575; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.32, 14.36], t(2038) = 0.23, p = 0.817; Std. beta = 0.04,
## 95% CI [-0.80, 0.87])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.20, 95% CI [-11.09, 6.68], t(2038) = -0.49, p = 0.627; Std. beta = -0.22,
## 95% CI [-0.81, 0.36])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.82, 95% CI [-21.62, 31.26], t(2038) = 0.36, p = 0.721; Std. beta = -2.33,
## 95% CI [-4.43, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-17.03, 19.54], t(2038) = 0.13, p = 0.893; Std. beta = 0.47,
## 95% CI [-0.83, 1.77])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.30, 95% CI [-29.64, 1.05], t(2038) = -1.83, p = 0.068; Std. beta = -0.46,
## 95% CI [-1.78, 0.86])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.10, 95% CI [-17.72, -0.49], t(2038) = -2.07, p = 0.038; Std. beta = -0.80,
## 95% CI [-1.84, 0.23])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.41, 95% CI [0.09, 0.74], t(2038) = 2.49, p = 0.013; Std.
## beta = 0.14, 95% CI [0.03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.05, 95% CI [-69.37, 3.27], t(2038) = -1.78, p = 0.074;
## Std. beta = -3.55, 95% CI [-7.46, 0.35])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.94, 95% CI [-10.77, 12.65], t(2038) = 0.16, p = 0.875; Std.
## beta = 0.10, 95% CI [-1.16, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-12.95, 11.50], t(2038) = -0.12, p = 0.908;
## Std. beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-17.92, 11.63], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-5.82, 13.82], t(2038) = 0.80, p = 0.425; Std.
## beta = 0.43, 95% CI [-0.63, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.95, 95% CI [-3.99, 2.09], t(2038) = -0.61, p = 0.540; Std.
## beta = -0.10, 95% CI [-0.43, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.40, 95% CI [-5.83, 10.62], t(2038) = 0.57, p = 0.568; Std.
## beta = 0.26, 95% CI [-0.63, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-1.49, 3.96], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.13, 95% CI [-0.16, 0.43])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.26, 95% CI [-3.49, 6.00], t(2038) = 0.52, p = 0.604; Std.
## beta = 0.13, 95% CI [-0.38, 0.65])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.10, 95% CI [1.18, 7.02], t(2038) = 2.75, p = 0.006; Std.
## beta = 0.44, 95% CI [0.13, 0.76])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-2.16, 13.12], t(2038) = 1.41, p = 0.160; Std.
## beta = 0.59, 95% CI [-0.23, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-0.92, 4.11], t(2038) = 1.25, p = 0.212; Std.
## beta = 0.17, 95% CI [-0.10, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.22, 6.72], t(2038) = 1.84, p = 0.067; Std.
## beta = 0.35, 95% CI [-0.02, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.69, 95% CI [-27.70, 4.32], t(2038) = -1.43, p = 0.152;
## Std. beta = -1.26, 95% CI [-2.98, 0.46])
## - The effect of time firstPFT × site [108] is statistically significant and
## positive (beta = 7.09, 95% CI [9.52e-03, 14.16], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.76, 95% CI [1.02e-03, 1.52])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.06, 95% CI [0.57, 11.54], t(2038) = 2.17, p = 0.030; Std.
## beta = 0.65, 95% CI [0.06, 1.24])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-5.15, 10.45], t(2038) = 0.67, p = 0.506; Std.
## beta = 0.28, 95% CI [-0.55, 1.12])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-6.76, 8.72], t(2038) = 0.25, p = 0.803; Std.
## beta = 0.11, 95% CI [-0.73, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.31, 95% CI [-55.75, 37.13], t(2038) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-5.99, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-29.23, 26.17], t(2038) = -0.11, p = 0.914;
## Std. beta = -0.16, 95% CI [-3.14, 2.81])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.12, 95% CI [-5.06, 5.29], t(2038) = 0.04, p = 0.965; Std.
## beta = 0.01, 95% CI [-0.54, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-34.85, 16.05], t(2038) = -0.72, p = 0.469;
## Std. beta = -1.01, 95% CI [-3.75, 1.73])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-3.04, 10.50], t(2038) = 1.08, p = 0.280; Std.
## beta = 0.40, 95% CI [-0.33, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.52, 95% CI [-4.22, 9.25], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.27, 95% CI [-0.45, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.14, 95% CI [-3.07, 15.34], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.66, 95% CI [-0.33, 1.65])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-9.28e-03, 10.92], t(2038) = 1.96, p = 0.050;
## Std. beta = 0.59, 95% CI [-9.97e-04, 1.17])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.64, 95% CI [-9.91, 11.19], t(2038) = 0.12, p = 0.905; Std.
## beta = 0.07, 95% CI [-1.07, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.65, 95% CI [-6.67, 3.37], t(2038) = -0.64, p = 0.519; Std.
## beta = -0.18, 95% CI [-0.72, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.29, 95% CI [-6.26, 5.67], t(2038) = -0.10, p = 0.923; Std.
## beta = -0.03, 95% CI [-0.67, 0.61])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.09, 95% CI [-34.71, 16.53], t(2038) = -0.70, p = 0.486;
## Std. beta = -0.98, 95% CI [-3.73, 1.78])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-11.12, 8.78], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.13, 95% CI [-1.19, 0.94])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-1.00, 7.08], t(2038) = 1.48, p = 0.140; Std.
## beta = 0.33, 95% CI [-0.11, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-6.84, 7.13], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.74, 0.77])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.79, 95% CI [-9.14, 5.57], t(2038) = -0.48, p = 0.634; Std.
## beta = -0.19, 95% CI [-0.98, 0.60])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.87, 95% CI [-1.99, 7.72], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.31, 95% CI [-0.21, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.20, 95% CI [1.94, 20.45], t(2038) = 2.37, p = 0.018; Std.
## beta = 1.20, 95% CI [0.21, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-0.23, 11.23], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.59, 95% CI [-0.02, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-6.24, 4.87], t(2038) = -0.24, p = 0.809; Std.
## beta = -0.07, 95% CI [-0.67, 0.52])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-4.59, 3.06], t(2038) = -0.39, p = 0.695; Std.
## beta = -0.08, 95% CI [-0.49, 0.33])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.40, 95% CI [-47.91, -6.89], t(2038) = -2.62, p = 0.009;
## Std. beta = -2.95, 95% CI [-5.15, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.99, 95% CI [-5.02, 12.99], t(2038) = 0.87, p = 0.385; Std.
## beta = 0.43, 95% CI [-0.54, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-7.86, 18.28], t(2038) = 0.78, p = 0.434; Std.
## beta = 0.56, 95% CI [-0.84, 1.97])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-13.58, 9.72], t(2038) = -0.32, p = 0.746; Std.
## beta = -0.21, 95% CI [-1.46, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*PM_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14685.2
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1271 -0.4941 -0.0056 0.4361 7.0929
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 139.00 11.790
## time_firstPFT 10.57 3.251 -0.27
## Residual 41.80 6.465
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 40.48524 6.76283 5.986
## time_firstPFT -7.93367 3.25826 -2.435
## PM_5yrPreDx -0.18287 0.35174 -0.520
## disadv -5.66984 2.34820 -2.415
## dich_RaceNon-White -2.92428 2.31373 -1.264
## sexF -2.42849 1.42917 -1.699
## age_dx 0.13211 0.07454 1.772
## smokeHxFormer -2.74968 1.41290 -1.946
## smokeHxAlways 9.30785 7.07870 1.315
## smokeHxUnknown -2.87080 3.19294 -0.899
## site02R -6.48851 13.54777 -0.479
## site03R 20.21859 10.03846 2.014
## site04R -5.30889 9.19464 -0.577
## site05R -13.07007 7.72010 -1.693
## site06R -8.28702 13.51548 -0.613
## site07R 3.03306 3.88003 0.782
## site09R -11.45710 9.44743 -1.213
## site101 19.36807 3.13355 6.181
## site102 6.52834 5.52813 1.181
## site103 -2.83715 3.28979 -0.862
## site104 -9.60409 5.79086 -1.658
## site105 1.49593 2.92481 0.511
## site106 -6.39560 3.68913 -1.734
## site107 7.42200 9.61304 0.772
## site108 -3.78266 8.32427 -0.454
## site10R 1.97680 13.46372 0.147
## site11R 1.34779 6.40561 0.210
## site12R -8.17051 9.36023 -0.873
## site13R -12.21941 7.36890 -1.658
## site14R -9.17482 15.00574 -0.611
## site15R -20.03379 13.55299 -1.478
## site16R -8.32189 5.95841 -1.397
## site17R 63.07344 13.68625 4.609
## site18R -3.69690 9.63616 -0.384
## site19R -7.56818 6.01655 -1.258
## site20R -3.68890 5.65050 -0.653
## site21R -12.57543 12.57117 -1.000
## site22R -14.01678 4.38385 -3.197
## site23R -25.65838 7.77090 -3.302
## site24R 1.11499 5.14760 0.217
## site25R -9.13858 5.68797 -1.607
## site28R -15.54170 7.88564 -1.971
## site29R -3.66298 13.29138 -0.276
## site31R -1.27277 5.98839 -0.213
## site32R 4.95536 6.79313 0.729
## site33R -9.41966 6.66890 -1.412
## site34R -5.44843 5.20115 -1.048
## site35R -15.08343 8.04845 -1.874
## site36R 3.09299 5.94346 0.520
## site37R -0.01464 6.57321 -0.002
## site38R -1.36344 4.49739 -0.303
## site39R 13.33649 13.64708 0.977
## site40R 0.03004 9.23062 0.003
## site41R -14.65002 7.81767 -1.874
## site42R -10.80027 4.40206 -2.453
## time_firstPFT:PM_5yrPreDx 0.35767 0.17763 2.014
## time_firstPFT:disadv 1.52904 1.08998 1.403
## time_firstPFT:dich_RaceNon-White -0.87731 1.10684 -0.793
## time_firstPFT:sexF 0.45535 0.65764 0.692
## time_firstPFT:age_dx -0.02825 0.03419 -0.826
## time_firstPFT:smokeHxFormer -0.60695 0.66347 -0.915
## time_firstPFT:smokeHxAlways -5.62787 6.03475 -0.933
## time_firstPFT:smokeHxUnknown 1.84336 1.65378 1.115
## time_firstPFT:site02R -31.80810 18.54626 -1.715
## time_firstPFT:site03R 0.99346 6.02577 0.165
## time_firstPFT:site04R -1.52656 6.27498 -0.243
## time_firstPFT:site05R -2.96642 7.55557 -0.393
## time_firstPFT:site07R -0.71882 1.58241 -0.454
## time_firstPFT:site09R 3.17547 4.22743 0.751
## time_firstPFT:site101 1.08493 1.42469 0.762
## time_firstPFT:site102 1.51889 2.47439 0.614
## time_firstPFT:site103 4.11468 1.60749 2.560
## time_firstPFT:site104 4.60957 3.97885 1.159
## time_firstPFT:site105 1.45723 1.30855 1.114
## time_firstPFT:site106 3.49747 1.82420 1.917
## time_firstPFT:site107 -11.12391 8.18311 -1.359
## time_firstPFT:site108 7.52658 3.85875 1.951
## time_firstPFT:site11R 6.42813 2.84862 2.257
## time_firstPFT:site12R 2.79359 4.00410 0.698
## time_firstPFT:site13R 0.84989 3.99171 0.213
## time_firstPFT:site14R -8.53223 23.70186 -0.360
## time_firstPFT:site15R -1.83797 14.15002 -0.130
## time_firstPFT:site16R -0.05182 2.71475 -0.019
## time_firstPFT:site18R -9.63876 12.99110 -0.742
## time_firstPFT:site19R 3.36119 3.48940 0.963
## time_firstPFT:site20R 2.15430 3.48956 0.617
## time_firstPFT:site21R 6.47326 4.71096 1.374
## time_firstPFT:site22R 6.37851 2.83174 2.253
## time_firstPFT:site23R 24.53654 26.79435 0.916
## time_firstPFT:site24R -1.59024 2.57807 -0.617
## time_firstPFT:site25R 0.37632 3.10775 0.121
## time_firstPFT:site28R -7.89082 13.14164 -0.600
## time_firstPFT:site29R 0.02958 5.11856 0.006
## time_firstPFT:site31R 3.65366 2.14180 1.706
## time_firstPFT:site32R 0.39659 3.60343 0.110
## time_firstPFT:site33R -2.56639 3.81756 -0.672
## time_firstPFT:site34R 2.65066 2.51480 1.054
## time_firstPFT:site35R 11.40067 4.75609 2.397
## time_firstPFT:site36R 5.44363 2.94786 1.847
## time_firstPFT:site37R -0.30835 2.95234 -0.104
## time_firstPFT:site38R -0.87422 1.96846 -0.444
## time_firstPFT:site39R -27.43512 10.57427 -2.595
## time_firstPFT:site40R 3.24136 4.65627 0.696
## time_firstPFT:site41R 5.71583 6.69216 0.854
## time_firstPFT:site42R -2.53159 5.95747 -0.425##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.790
## Unadjusted ICC: 0.531report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## PM_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to time_firstPFT = 0, is at 40.49 (95% CI [27.22, 53.75], t(2008)
## = 5.99, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## PM_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to PM_5yrPreDx =
## 0, is at 40.49 (95% CI [27.22, 53.75], t(2008) = 5.99, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to disadv = 0, is at 40.49 (95% CI [27.22,
## 53.75], t(2008) = 5.99, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to dich_Race = White, is at 40.49 (95% CI
## [27.22, 53.75], t(2008) = 5.99, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to sex = M, is at 40.49 (95% CI [27.22,
## 53.75], t(2008) = 5.99, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to age_dx = 0, is at 40.49 (95% CI [27.22,
## 53.75], t(2008) = 5.99, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to smokeHx = Never, is at 40.49 (95% CI
## [27.22, 53.75], t(2008) = 5.99, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to site = Simmons, is at 40.49 (95% CI [27.22,
## 53.75], t(2008) = 5.99, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to cohort =
## CARE-PF, is at 40.49 (95% CI [27.22, 53.75], t(2008) = 5.99, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.93, 95% CI [-14.32, -1.54], t(2008) = -2.43, p = 0.015; Std. beta = -0.58,
## 95% CI [-0.77, -0.39])
## - The effect of PM 5yrPreDx is statistically non-significant and negative (beta
## = -0.18, 95% CI [-0.87, 0.51], t(2008) = -0.52, p = 0.603; Std. beta = 0.07,
## 95% CI [-0.09, 0.23])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.28, -1.06], t(2008) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.46, 1.61], t(2008) = -1.26, p = 0.206; Std.
## beta = -0.28, 95% CI [-0.60, 0.03])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.43, 95% CI [-5.23, 0.37], t(2008) = -1.70, p = 0.089; Std. beta = -0.12, 95%
## CI [-0.31, 0.07])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.77, p = 0.076; Std. beta = 0.06, 95% CI
## [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.57, 23.19], t(2008) = 1.31, p = 0.189; Std. beta =
## 0.08, 95% CI [-1.13, 1.29])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.87, 95% CI [-9.13, 3.39], t(2008) = -0.90, p = 0.369; Std. beta =
## -0.01, 95% CI [-0.47, 0.44])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-33.06, 20.08], t(2008) = -0.48, p = 0.632; Std. beta = -3.53,
## 95% CI [-6.76, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.22, 95% CI [0.53, 39.91], t(2008) = 2.01, p = 0.044; Std. beta = 1.46, 95%
## CI [0.19, 2.73])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.31, 95% CI [-23.34, 12.72], t(2008) = -0.58, p = 0.564; Std. beta = -0.51,
## 95% CI [-1.91, 0.89])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.07, 95% CI [-28.21, 2.07], t(2008) = -1.69, p = 0.091; Std. beta = -1.17,
## 95% CI [-2.60, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-34.79, 18.22], t(2008) = -0.61, p = 0.540; Std. beta = -0.56,
## 95% CI [-2.35, 1.23])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-4.58, 10.64], t(2008) = 0.78, p = 0.434; Std. beta = 0.13, 95%
## CI [-0.36, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-29.98, 7.07], t(2008) = -1.21, p = 0.225; Std. beta = -0.46,
## 95% CI [-1.73, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.37, 95% CI [13.22, 25.51], t(2008) = 6.18, p < .001; Std. beta = 1.41, 95%
## CI [0.99, 1.83])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.53, 95% CI [-4.31, 17.37], t(2008) = 1.18, p = 0.238; Std. beta = 0.59, 95%
## CI [-0.13, 1.31])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.84, 95% CI [-9.29, 3.61], t(2008) = -0.86, p = 0.389; Std. beta = 0.21,
## 95% CI [-0.24, 0.66])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.60, 95% CI [-20.96, 1.75], t(2008) = -1.66, p = 0.097; Std. beta = -0.20,
## 95% CI [-1.12, 0.71])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.50, 95% CI [-4.24, 7.23], t(2008) = 0.51, p = 0.609; Std. beta = 0.24, 95%
## CI [-0.14, 0.63])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.40, 95% CI [-13.63, 0.84], t(2008) = -1.73, p = 0.083; Std. beta = -0.09,
## 95% CI [-0.58, 0.39])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.42, 95% CI [-11.43, 26.27], t(2008) = 0.77, p = 0.440; Std. beta = -0.58,
## 95% CI [-2.16, 0.99])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.78, 95% CI [-20.11, 12.54], t(2008) = -0.45, p = 0.650; Std. beta = 0.48,
## 95% CI [-0.60, 1.55])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.43, 28.38], t(2008) = 0.15, p = 0.883; Std. beta = 0.13,
## 95% CI [-1.65, 1.92])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.35, 95% CI [-11.21, 13.91], t(2008) = 0.21, p = 0.833; Std. beta = 0.72,
## 95% CI [-0.14, 1.57])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-26.53, 10.19], t(2008) = -0.87, p = 0.383; Std. beta = -0.28,
## 95% CI [-1.54, 0.98])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.22, 95% CI [-26.67, 2.23], t(2008) = -1.66, p = 0.097; Std. beta = -0.74,
## 95% CI [-1.70, 0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.60, 20.25], t(2008) = -0.61, p = 0.541; Std. beta = -1.45,
## 95% CI [-4.64, 1.74])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -20.03, 95% CI [-46.61, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.53,
## 95% CI [-4.04, 0.98])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.32, 95% CI [-20.01, 3.36], t(2008) = -1.40, p = 0.163; Std. beta = -0.57,
## 95% CI [-1.38, 0.24])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.07, 95% CI [36.23, 89.91], t(2008) = 4.61, p < .001; Std. beta = 4.26, 95%
## CI [2.45, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-22.59, 15.20], t(2008) = -0.38, p = 0.701; Std. beta = -1.19,
## 95% CI [-3.59, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-19.37, 4.23], t(2008) = -1.26, p = 0.209; Std. beta = -0.18,
## 95% CI [-1.04, 0.67])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.69, 95% CI [-14.77, 7.39], t(2008) = -0.65, p = 0.514; Std. beta = -0.04,
## 95% CI [-0.85, 0.77])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.58, 95% CI [-37.23, 12.08], t(2008) = -1.00, p = 0.317; Std. beta =
## -0.22, 95% CI [-1.78, 1.34])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.02, 95% CI [-22.61, -5.42], t(2008) = -3.20, p = 0.001; Std. beta = -0.33,
## 95% CI [-0.96, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.66, 95% CI [-40.90, -10.42], t(2008) = -3.30, p < .001; Std. beta = 0.65,
## 95% CI [-4.04, 5.35])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.11, 95% CI [-8.98, 11.21], t(2008) = 0.22, p = 0.829; Std. beta = -0.08,
## 95% CI [-0.76, 0.61])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.14, 95% CI [-20.29, 2.02], t(2008) = -1.61, p = 0.108; Std. beta = -0.58,
## 95% CI [-1.35, 0.19])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.54, 95% CI [-31.01, -0.08], t(2008) = -1.97, p = 0.049; Std. beta = -1.82,
## 95% CI [-4.27, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-29.73, 22.40], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-1.85, 1.36])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.27, 95% CI [-13.02, 10.47], t(2008) = -0.21, p = 0.832; Std. beta = 0.27,
## 95% CI [-0.48, 1.02])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.96, 95% CI [-8.37, 18.28], t(2008) = 0.73, p = 0.466; Std. beta = 0.37, 95%
## CI [-0.55, 1.30])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.42, 95% CI [-22.50, 3.66], t(2008) = -1.41, p = 0.158; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.65, 4.75], t(2008) = -1.05, p = 0.295; Std. beta = -0.11,
## 95% CI [-0.81, 0.59])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.08, 95% CI [-30.87, 0.70], t(2008) = -1.87, p = 0.061; Std. beta = 0.09,
## 95% CI [-1.02, 1.20])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.09, 95% CI [-8.56, 14.75], t(2008) = 0.52, p = 0.603; Std. beta = 0.74, 95%
## CI [-0.08, 1.56])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.01, 95% CI [-12.91, 12.88], t(2008) = -2.23e-03, p = 0.998; Std. beta =
## -0.03, 95% CI [-0.88, 0.82])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.36, 95% CI [-10.18, 7.46], t(2008) = -0.30, p = 0.762; Std. beta = -0.18,
## 95% CI [-0.76, 0.41])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 13.34, 95% CI [-13.43, 40.10], t(2008) = 0.98, p = 0.329; Std. beta = -1.77,
## 95% CI [-3.91, 0.37])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.03, 95% CI [-18.07, 18.13], t(2008) = 3.25e-03, p = 0.997; Std. beta =
## 0.32, 95% CI [-0.99, 1.62])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.65, 95% CI [-29.98, 0.68], t(2008) = -1.87, p = 0.061; Std. beta = -0.43,
## 95% CI [-1.76, 0.89])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.80, 95% CI [-19.43, -2.17], t(2008) = -2.45, p = 0.014; Std. beta = -0.98,
## 95% CI [-2.02, 0.07])
## - The effect of time firstPFT × PM 5yrPreDx is statistically significant and
## positive (beta = 0.36, 95% CI [9.31e-03, 0.71], t(2008) = 2.01, p = 0.044; Std.
## beta = 0.12, 95% CI [3.23e-03, 0.24])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.53, 95% CI [-0.61, 3.67], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.05, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.88, 95% CI [-3.05, 1.29], t(2008) =
## -0.79, p = 0.428; Std. beta = -0.09, 95% CI [-0.33, 0.14])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.46, 95% CI [-0.83, 1.75], t(2008) = 0.69, p = 0.489; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.83, p = 0.409; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.91, 0.69], t(2008) =
## -0.91, p = 0.360; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.63, 95% CI [-17.46, 6.21], t(2008) =
## -0.93, p = 0.351; Std. beta = -0.61, 95% CI [-1.88, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.84, 95% CI [-1.40, 5.09], t(2008) =
## 1.11, p = 0.265; Std. beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.81, 95% CI [-68.18, 4.56], t(2008) = -1.72, p = 0.086;
## Std. beta = -3.42, 95% CI [-7.34, 0.49])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-10.82, 12.81], t(2008) = 0.16, p = 0.869; Std.
## beta = 0.11, 95% CI [-1.17, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.53, 95% CI [-13.83, 10.78], t(2008) = -0.24, p = 0.808;
## Std. beta = -0.16, 95% CI [-1.49, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-17.78, 11.85], t(2008) = -0.39, p = 0.695;
## Std. beta = -0.32, 95% CI [-1.91, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.72, 95% CI [-3.82, 2.38], t(2008) = -0.45, p = 0.650; Std.
## beta = -0.08, 95% CI [-0.41, 0.26])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.18, 95% CI [-5.12, 11.47], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.34, 95% CI [-0.55, 1.23])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-1.71, 3.88], t(2008) = 0.76, p = 0.446; Std.
## beta = 0.12, 95% CI [-0.18, 0.42])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.52, 95% CI [-3.33, 6.37], t(2008) = 0.61, p = 0.539; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.11, 95% CI [0.96, 7.27], t(2008) = 2.56, p = 0.011; Std.
## beta = 0.44, 95% CI [0.10, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.61, 95% CI [-3.19, 12.41], t(2008) = 1.16, p = 0.247; Std.
## beta = 0.50, 95% CI [-0.34, 1.34])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.11, 4.02], t(2008) = 1.11, p = 0.266; Std.
## beta = 0.16, 95% CI [-0.12, 0.43])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.50, 95% CI [-0.08, 7.08], t(2008) = 1.92, p = 0.055; Std.
## beta = 0.38, 95% CI [-8.62e-03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.12, 95% CI [-27.17, 4.92], t(2008) = -1.36, p = 0.174;
## Std. beta = -1.20, 95% CI [-2.93, 0.53])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.53, 95% CI [-0.04, 15.09], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.81, 95% CI [-4.41e-03, 1.62])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.43, 95% CI [0.84, 12.01], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.29])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.79, 95% CI [-5.06, 10.65], t(2008) = 0.70, p = 0.485; Std.
## beta = 0.30, 95% CI [-0.54, 1.15])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-6.98, 8.68], t(2008) = 0.21, p = 0.831; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.53, 95% CI [-55.02, 37.95], t(2008) = -0.36, p = 0.719;
## Std. beta = -0.92, 95% CI [-5.92, 4.09])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-29.59, 25.91], t(2008) = -0.13, p = 0.897;
## Std. beta = -0.20, 95% CI [-3.19, 2.79])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-5.38, 5.27], t(2008) = -0.02, p = 0.985; Std.
## beta = -5.58e-03, 95% CI [-0.58, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.12, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-3.48, 10.20], t(2008) = 0.96, p = 0.336; Std.
## beta = 0.36, 95% CI [-0.37, 1.10])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.69, 9.00], t(2008) = 0.62, p = 0.537; Std.
## beta = 0.23, 95% CI [-0.50, 0.97])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.47, 95% CI [-2.77, 15.71], t(2008) = 1.37, p = 0.170; Std.
## beta = 0.70, 95% CI [-0.30, 1.69])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.38, 95% CI [0.83, 11.93], t(2008) = 2.25, p = 0.024; Std.
## beta = 0.69, 95% CI [0.09, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.54, 95% CI [-28.01, 77.08], t(2008) = 0.92, p = 0.360; Std.
## beta = 2.64, 95% CI [-3.02, 8.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-6.65, 3.47], t(2008) = -0.62, p = 0.537; Std.
## beta = -0.17, 95% CI [-0.72, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.38, 95% CI [-5.72, 6.47], t(2008) = 0.12, p = 0.904; Std.
## beta = 0.04, 95% CI [-0.62, 0.70])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.89, 95% CI [-33.66, 17.88], t(2008) = -0.60, p = 0.548;
## Std. beta = -0.85, 95% CI [-3.62, 1.92])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.03, 95% CI [-10.01, 10.07], t(2008) = 5.78e-03, p = 0.995;
## Std. beta = 3.18e-03, 95% CI [-1.08, 1.08])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-0.55, 7.85], t(2008) = 1.71, p = 0.088; Std.
## beta = 0.39, 95% CI [-0.06, 0.85])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-6.67, 7.46], t(2008) = 0.11, p = 0.912; Std.
## beta = 0.04, 95% CI [-0.72, 0.80])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.57, 95% CI [-10.05, 4.92], t(2008) = -0.67, p = 0.501; Std.
## beta = -0.28, 95% CI [-1.08, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.65, 95% CI [-2.28, 7.58], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.29, 95% CI [-0.25, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.40, 95% CI [2.07, 20.73], t(2008) = 2.40, p = 0.017; Std.
## beta = 1.23, 95% CI [0.22, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.44, 95% CI [-0.34, 11.22], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.59, 95% CI [-0.04, 1.21])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.10, 5.48], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-4.73, 2.99], t(2008) = -0.44, p = 0.657; Std.
## beta = -0.09, 95% CI [-0.51, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.44, 95% CI [-48.17, -6.70], t(2008) = -2.59, p = 0.010;
## Std. beta = -2.95, 95% CI [-5.19, -0.72])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-5.89, 12.37], t(2008) = 0.70, p = 0.486; Std.
## beta = 0.35, 95% CI [-0.63, 1.33])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-7.41, 18.84], t(2008) = 0.85, p = 0.393; Std.
## beta = 0.62, 95% CI [-0.80, 2.03])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.22, 9.15], t(2008) = -0.42, p = 0.671; Std.
## beta = -0.27, 95% CI [-1.53, 0.99])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*SO4_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14852.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1416 -0.4981 -0.0095 0.4361 7.1235
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 144.16 12.007
## time_firstPFT 10.57 3.251 -0.31
## Residual 41.75 6.461
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 38.8501 3.3309 11.663
## time_firstPFT -8.1877 1.7659 -4.637
## SO4_5yrPreDx 0.4002 0.7614 0.526
## site02R -0.6286 13.8667 -0.045
## site03R 26.7077 10.2072 2.617
## site04R -4.4883 9.4517 -0.475
## site05R -12.3576 7.7901 -1.586
## site06R 5.6824 9.8340 0.578
## site07R 6.4336 4.0846 1.575
## site09R -7.4051 9.6179 -0.770
## site101 21.3539 3.2783 6.514
## site102 10.4764 5.6545 1.853
## site103 -0.2774 3.4903 -0.079
## site104 -7.8014 5.9132 -1.319
## site105 2.9612 3.3149 0.893
## site106 -2.5679 3.8612 -0.665
## site107 11.7492 9.8383 1.194
## site108 -6.0224 8.0263 -0.750
## site10R 4.5054 13.5211 0.333
## site11R 3.7783 6.6224 0.571
## site12R -7.6787 9.5786 -0.802
## site13R -9.0578 7.5025 -1.207
## site14R -5.2782 15.1025 -0.349
## site15R -22.9100 13.6928 -1.673
## site16R -7.7501 5.9829 -1.295
## site17R 60.4197 13.7782 4.385
## site18R -3.7518 9.8307 -0.382
## site19R -4.2306 6.1650 -0.686
## site20R -1.7943 5.8252 -0.308
## site21R -11.8703 12.8265 -0.925
## site22R -10.0489 4.5258 -2.220
## site23R -17.8424 6.3329 -2.817
## site24R 3.4939 5.4307 0.643
## site25R -4.4977 6.1360 -0.733
## site28R -16.7184 7.9576 -2.101
## site29R 1.8149 13.4654 0.135
## site31R 1.1516 6.0204 0.191
## site32R 6.8917 7.1751 0.961
## site33R -7.5259 6.7702 -1.112
## site34R -3.5868 5.3117 -0.675
## site35R -11.9242 8.1922 -1.456
## site36R 4.3579 6.0425 0.721
## site37R 2.8230 6.6549 0.424
## site38R -0.6280 4.6446 -0.135
## site39R 8.2562 13.5582 0.609
## site40R 3.0450 9.6107 0.317
## site41R -12.1050 7.9908 -1.515
## site42R -7.7939 4.5237 -1.723
## time_firstPFT:SO4_5yrPreDx 0.8554 0.3826 2.236
## time_firstPFT:site02R -31.5262 18.5677 -1.698
## time_firstPFT:site03R 1.8008 6.0638 0.297
## time_firstPFT:site04R 0.3886 6.2955 0.062
## time_firstPFT:site05R -3.0173 7.5364 -0.400
## time_firstPFT:site06R 5.2031 5.0758 1.025
## time_firstPFT:site07R -0.4603 1.7043 -0.270
## time_firstPFT:site09R 3.1597 4.2725 0.740
## time_firstPFT:site101 1.4804 1.5318 0.966
## time_firstPFT:site102 1.6547 2.5798 0.641
## time_firstPFT:site103 4.5071 1.7436 2.585
## time_firstPFT:site104 5.6504 3.9758 1.421
## time_firstPFT:site105 2.3288 1.5583 1.494
## time_firstPFT:site106 3.5928 1.8921 1.899
## time_firstPFT:site107 -10.8255 8.2205 -1.317
## time_firstPFT:site108 7.0823 3.6756 1.927
## time_firstPFT:site11R 6.9487 2.9011 2.395
## time_firstPFT:site12R 3.4281 4.0612 0.844
## time_firstPFT:site13R 1.5593 4.0122 0.389
## time_firstPFT:site14R -9.0610 23.6866 -0.383
## time_firstPFT:site15R -0.9868 14.1365 -0.070
## time_firstPFT:site16R 0.7471 2.7234 0.274
## time_firstPFT:site18R -8.7428 12.9941 -0.673
## time_firstPFT:site19R 3.9067 3.5356 1.105
## time_firstPFT:site20R 3.1606 3.5161 0.899
## time_firstPFT:site21R 7.1602 4.7594 1.504
## time_firstPFT:site22R 5.8999 2.8422 2.076
## time_firstPFT:site23R 0.9930 5.4097 0.184
## time_firstPFT:site24R -0.9275 2.7140 -0.342
## time_firstPFT:site25R 0.9700 3.2717 0.296
## time_firstPFT:site28R -7.9993 13.0657 -0.612
## time_firstPFT:site29R -0.7730 5.1249 -0.151
## time_firstPFT:site31R 3.2519 2.1362 1.522
## time_firstPFT:site32R 1.7962 3.7819 0.475
## time_firstPFT:site33R -1.6387 3.7737 -0.434
## time_firstPFT:site34R 3.0494 2.5385 1.201
## time_firstPFT:site35R 11.2353 4.7579 2.361
## time_firstPFT:site36R 5.8390 2.9443 1.983
## time_firstPFT:site37R 0.1144 2.9152 0.039
## time_firstPFT:site38R -0.2284 2.0542 -0.111
## time_firstPFT:site39R -27.2009 10.4918 -2.593
## time_firstPFT:site40R 5.0620 4.7194 1.073
## time_firstPFT:site41R 5.9772 6.7233 0.889
## time_firstPFT:site42R -1.2699 5.9666 -0.213##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.791
## Unadjusted ICC: 0.548report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SO4_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.31. The model's
## intercept, corresponding to time_firstPFT = 0, is at 38.85 (95% CI [32.32,
## 45.38], t(2038) = 11.66, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -8.19, 95% CI [-11.65, -4.72], t(2038) = -4.64, p < .001; Std. beta = -0.64,
## 95% CI [-0.82, -0.46])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.40, 95% CI [-1.09, 1.89], t(2038) = 0.53, p = 0.599; Std. beta =
## 0.19, 95% CI [8.41e-03, 0.37])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-27.82, 26.57], t(2038) = -0.05, p = 0.964; Std. beta = -3.10,
## 95% CI [-6.33, 0.14])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.71, 95% CI [6.69, 46.73], t(2038) = 2.62, p = 0.009; Std. beta = 1.98, 95%
## CI [0.70, 3.26])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-23.02, 14.05], t(2038) = -0.47, p = 0.635; Std. beta = -0.27,
## 95% CI [-1.68, 1.15])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-27.63, 2.92], t(2038) = -1.59, p = 0.113; Std. beta = -1.13,
## 95% CI [-2.55, 0.29])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.68, 95% CI [-13.60, 24.97], t(2038) = 0.58, p = 0.563; Std. beta = 0.89,
## 95% CI [-0.46, 2.24])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.43, 95% CI [-1.58, 14.44], t(2038) = 1.58, p = 0.115; Std. beta = 0.39, 95%
## CI [-0.13, 0.91])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -7.41, 95% CI [-26.27, 11.46], t(2038) = -0.77, p = 0.441; Std. beta = -0.19,
## 95% CI [-1.46, 1.07])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.35, 95% CI [14.92, 27.78], t(2038) = 6.51, p < .001; Std. beta = 1.59, 95%
## CI [1.15, 2.03])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-0.61, 21.57], t(2038) = 1.85, p = 0.064; Std. beta = 0.87,
## 95% CI [0.13, 1.61])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-7.12, 6.57], t(2038) = -0.08, p = 0.937; Std. beta = 0.42,
## 95% CI [-0.06, 0.90])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-19.40, 3.80], t(2038) = -1.32, p = 0.187; Std. beta = 0.02,
## 95% CI [-0.90, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.54, 9.46], t(2038) = 0.89, p = 0.372; Std. beta = 0.43, 95%
## CI [-0.02, 0.87])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-10.14, 5.00], t(2038) = -0.67, p = 0.506; Std. beta = 0.17,
## 95% CI [-0.33, 0.68])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.75, 95% CI [-7.54, 31.04], t(2038) = 1.19, p = 0.233; Std. beta = -0.26,
## 95% CI [-1.84, 1.33])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -6.02, 95% CI [-21.76, 9.72], t(2038) = -0.75, p = 0.453; Std. beta = 0.28,
## 95% CI [-0.74, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.51, 95% CI [-22.01, 31.02], t(2038) = 0.33, p = 0.739; Std. beta = 0.30,
## 95% CI [-1.49, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.21, 16.77], t(2038) = 0.57, p = 0.568; Std. beta = 0.93, 95%
## CI [0.06, 1.80])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-26.46, 11.11], t(2038) = -0.80, p = 0.423; Std. beta = -0.19,
## 95% CI [-1.46, 1.08])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.06, 95% CI [-23.77, 5.66], t(2038) = -1.21, p = 0.227; Std. beta = -0.46,
## 95% CI [-1.42, 0.50])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-34.90, 24.34], t(2038) = -0.35, p = 0.727; Std. beta = -1.24,
## 95% CI [-4.41, 1.94])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.91, 95% CI [-49.76, 3.94], t(2038) = -1.67, p = 0.094; Std. beta = -1.64,
## 95% CI [-4.14, 0.86])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.75, 95% CI [-19.48, 3.98], t(2038) = -1.30, p = 0.195; Std. beta = -0.45,
## 95% CI [-1.26, 0.35])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.42, 95% CI [33.40, 87.44], t(2038) = 4.39, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.91])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-23.03, 15.53], t(2038) = -0.38, p = 0.703; Std. beta = -1.10,
## 95% CI [-3.50, 1.30])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.23, 95% CI [-16.32, 7.86], t(2038) = -0.69, p = 0.493; Std. beta = 0.09,
## 95% CI [-0.77, 0.96])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-13.22, 9.63], t(2038) = -0.31, p = 0.758; Std. beta = 0.19,
## 95% CI [-0.64, 1.01])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.87, 95% CI [-37.02, 13.28], t(2038) = -0.93, p = 0.355; Std. beta =
## -0.11, 95% CI [-1.69, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.05, 95% CI [-18.92, -1.17], t(2038) = -2.22, p = 0.027; Std. beta = -0.11,
## 95% CI [-0.75, 0.54])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.84, 95% CI [-30.26, -5.42], t(2038) = -2.82, p = 0.005; Std. beta = -1.11,
## 95% CI [-2.24, 0.02])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-7.16, 14.14], t(2038) = 0.64, p = 0.520; Std. beta = 0.15, 95%
## CI [-0.57, 0.86])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.50, 95% CI [-16.53, 7.54], t(2038) = -0.73, p = 0.464; Std. beta = -0.21,
## 95% CI [-1.03, 0.61])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.72, 95% CI [-32.32, -1.11], t(2038) = -2.10, p = 0.036; Std. beta = -1.91,
## 95% CI [-4.33, 0.52])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-24.59, 28.22], t(2038) = 0.13, p = 0.893; Std. beta = 0.05,
## 95% CI [-1.56, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.15, 95% CI [-10.66, 12.96], t(2038) = 0.19, p = 0.848; Std. beta = 0.39,
## 95% CI [-0.35, 1.14])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.89, 95% CI [-7.18, 20.96], t(2038) = 0.96, p = 0.337; Std. beta = 0.64, 95%
## CI [-0.33, 1.61])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-20.80, 5.75], t(2038) = -1.11, p = 0.266; Std. beta = -0.67,
## 95% CI [-1.64, 0.31])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-14.00, 6.83], t(2038) = -0.68, p = 0.500; Std. beta = 0.05,
## 95% CI [-0.65, 0.76])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.99, 4.14], t(2038) = -1.46, p = 0.146; Std. beta = 0.28,
## 95% CI [-0.83, 1.40])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-7.49, 16.21], t(2038) = 0.72, p = 0.471; Std. beta = 0.86, 95%
## CI [0.04, 1.68])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-10.23, 15.87], t(2038) = 0.42, p = 0.671; Std. beta = 0.20,
## 95% CI [-0.65, 1.05])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-9.74, 8.48], t(2038) = -0.14, p = 0.892; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-18.33, 34.85], t(2038) = 0.61, p = 0.543; Std. beta = -2.08,
## 95% CI [-4.19, 0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-15.80, 21.89], t(2038) = 0.32, p = 0.751; Std. beta = 0.70,
## 95% CI [-0.63, 2.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.11, 95% CI [-27.78, 3.57], t(2038) = -1.51, p = 0.130; Std. beta = -0.24,
## 95% CI [-1.57, 1.10])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-16.67, 1.08], t(2038) = -1.72, p = 0.085; Std. beta = -0.65,
## 95% CI [-1.69, 0.39])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically significant and
## positive (beta = 0.86, 95% CI [0.11, 1.61], t(2038) = 2.24, p = 0.025; Std.
## beta = 0.16, 95% CI [0.02, 0.30])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.53, 95% CI [-67.94, 4.89], t(2038) = -1.70, p = 0.090;
## Std. beta = -3.39, 95% CI [-7.30, 0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-10.09, 13.69], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.19, 95% CI [-1.08, 1.47])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-11.96, 12.73], t(2038) = 0.06, p = 0.951; Std.
## beta = 0.04, 95% CI [-1.29, 1.37])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-17.80, 11.76], t(2038) = -0.40, p = 0.689;
## Std. beta = -0.32, 95% CI [-1.91, 1.26])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-4.75, 15.16], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.56, 95% CI [-0.51, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-3.80, 2.88], t(2038) = -0.27, p = 0.787; Std.
## beta = -0.05, 95% CI [-0.41, 0.31])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-5.22, 11.54], t(2038) = 0.74, p = 0.460; Std.
## beta = 0.34, 95% CI [-0.56, 1.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-1.52, 4.48], t(2038) = 0.97, p = 0.334; Std.
## beta = 0.16, 95% CI [-0.16, 0.48])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.40, 6.71], t(2038) = 0.64, p = 0.521; Std.
## beta = 0.18, 95% CI [-0.37, 0.72])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.93], t(2038) = 2.58, p = 0.010; Std.
## beta = 0.48, 95% CI [0.12, 0.85])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.65, 95% CI [-2.15, 13.45], t(2038) = 1.42, p = 0.155; Std.
## beta = 0.61, 95% CI [-0.23, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-0.73, 5.38], t(2038) = 1.49, p = 0.135; Std.
## beta = 0.25, 95% CI [-0.08, 0.58])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-0.12, 7.30], t(2038) = 1.90, p = 0.058; Std.
## beta = 0.39, 95% CI [-0.01, 0.79])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-26.95, 5.30], t(2038) = -1.32, p = 0.188;
## Std. beta = -1.16, 95% CI [-2.90, 0.57])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.08, 95% CI [-0.13, 14.29], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.76, 95% CI [-0.01, 1.54])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.95, 95% CI [1.26, 12.64], t(2038) = 2.40, p = 0.017; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.43, 95% CI [-4.54, 11.39], t(2038) = 0.84, p = 0.399; Std.
## beta = 0.37, 95% CI [-0.49, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.31, 9.43], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.17, 95% CI [-0.68, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.06, 95% CI [-55.51, 37.39], t(2038) = -0.38, p = 0.702;
## Std. beta = -0.97, 95% CI [-5.97, 4.02])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-28.71, 26.74], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.11, 95% CI [-3.09, 2.87])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-4.59, 6.09], t(2038) = 0.27, p = 0.784; Std.
## beta = 0.08, 95% CI [-0.49, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.74, 95% CI [-34.23, 16.74], t(2038) = -0.67, p = 0.501;
## Std. beta = -0.94, 95% CI [-3.68, 1.80])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.91, 95% CI [-3.03, 10.84], t(2038) = 1.10, p = 0.269; Std.
## beta = 0.42, 95% CI [-0.33, 1.17])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-3.73, 10.06], t(2038) = 0.90, p = 0.369; Std.
## beta = 0.34, 95% CI [-0.40, 1.08])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-2.17, 16.49], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.77, 95% CI [-0.23, 1.77])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.90, 95% CI [0.33, 11.47], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-9.62, 11.60], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-6.25, 4.40], t(2038) = -0.34, p = 0.733; Std.
## beta = -0.10, 95% CI [-0.67, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-5.45, 7.39], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.00, 95% CI [-33.62, 17.62], t(2038) = -0.61, p = 0.540;
## Std. beta = -0.86, 95% CI [-3.61, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.82, 9.28], t(2038) = -0.15, p = 0.880; Std.
## beta = -0.08, 95% CI [-1.16, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.94, 7.44], t(2038) = 1.52, p = 0.128; Std.
## beta = 0.35, 95% CI [-0.10, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.62, 9.21], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-9.04, 5.76], t(2038) = -0.43, p = 0.664; Std.
## beta = -0.18, 95% CI [-0.97, 0.62])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 3.05, 95% CI [-1.93, 8.03], t(2038) = 1.20, p = 0.230; Std.
## beta = 0.33, 95% CI [-0.21, 0.86])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.24, 95% CI [1.90, 20.57], t(2038) = 2.36, p = 0.018; Std.
## beta = 1.21, 95% CI [0.20, 2.21])
## - The effect of time firstPFT × site [36R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.06, 11.61], t(2038) = 1.98, p = 0.047; Std.
## beta = 0.63, 95% CI [6.98e-03, 1.25])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-5.60, 5.83], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.01, 95% CI [-0.60, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-4.26, 3.80], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.02, 95% CI [-0.46, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.20, 95% CI [-47.78, -6.63], t(2038) = -2.59, p = 0.010;
## Std. beta = -2.92, 95% CI [-5.14, -0.71])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 5.06, 95% CI [-4.19, 14.32], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.54, 95% CI [-0.45, 1.54])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-7.21, 19.16], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.64, 95% CI [-0.77, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-12.97, 10.43], t(2038) = -0.21, p = 0.831;
## Std. beta = -0.14, 95% CI [-1.39, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SO4_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.31. The model's intercept,
## corresponding to SO4_5yrPreDx = 0, is at 38.85 (95% CI [32.32, 45.38], t(2038)
## = 11.66, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -8.19, 95% CI [-11.65, -4.72], t(2038) = -4.64, p < .001; Std. beta = -0.64,
## 95% CI [-0.82, -0.46])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.40, 95% CI [-1.09, 1.89], t(2038) = 0.53, p = 0.599; Std. beta =
## 0.19, 95% CI [8.41e-03, 0.37])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-27.82, 26.57], t(2038) = -0.05, p = 0.964; Std. beta = -3.10,
## 95% CI [-6.33, 0.14])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.71, 95% CI [6.69, 46.73], t(2038) = 2.62, p = 0.009; Std. beta = 1.98, 95%
## CI [0.70, 3.26])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-23.02, 14.05], t(2038) = -0.47, p = 0.635; Std. beta = -0.27,
## 95% CI [-1.68, 1.15])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-27.63, 2.92], t(2038) = -1.59, p = 0.113; Std. beta = -1.13,
## 95% CI [-2.55, 0.29])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.68, 95% CI [-13.60, 24.97], t(2038) = 0.58, p = 0.563; Std. beta = 0.89,
## 95% CI [-0.46, 2.24])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.43, 95% CI [-1.58, 14.44], t(2038) = 1.58, p = 0.115; Std. beta = 0.39, 95%
## CI [-0.13, 0.91])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -7.41, 95% CI [-26.27, 11.46], t(2038) = -0.77, p = 0.441; Std. beta = -0.19,
## 95% CI [-1.46, 1.07])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.35, 95% CI [14.92, 27.78], t(2038) = 6.51, p < .001; Std. beta = 1.59, 95%
## CI [1.15, 2.03])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-0.61, 21.57], t(2038) = 1.85, p = 0.064; Std. beta = 0.87,
## 95% CI [0.13, 1.61])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-7.12, 6.57], t(2038) = -0.08, p = 0.937; Std. beta = 0.42,
## 95% CI [-0.06, 0.90])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-19.40, 3.80], t(2038) = -1.32, p = 0.187; Std. beta = 0.02,
## 95% CI [-0.90, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.54, 9.46], t(2038) = 0.89, p = 0.372; Std. beta = 0.43, 95%
## CI [-0.02, 0.87])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-10.14, 5.00], t(2038) = -0.67, p = 0.506; Std. beta = 0.17,
## 95% CI [-0.33, 0.68])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.75, 95% CI [-7.54, 31.04], t(2038) = 1.19, p = 0.233; Std. beta = -0.26,
## 95% CI [-1.84, 1.33])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -6.02, 95% CI [-21.76, 9.72], t(2038) = -0.75, p = 0.453; Std. beta = 0.28,
## 95% CI [-0.74, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.51, 95% CI [-22.01, 31.02], t(2038) = 0.33, p = 0.739; Std. beta = 0.30,
## 95% CI [-1.49, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.21, 16.77], t(2038) = 0.57, p = 0.568; Std. beta = 0.93, 95%
## CI [0.06, 1.80])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-26.46, 11.11], t(2038) = -0.80, p = 0.423; Std. beta = -0.19,
## 95% CI [-1.46, 1.08])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.06, 95% CI [-23.77, 5.66], t(2038) = -1.21, p = 0.227; Std. beta = -0.46,
## 95% CI [-1.42, 0.50])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-34.90, 24.34], t(2038) = -0.35, p = 0.727; Std. beta = -1.24,
## 95% CI [-4.41, 1.94])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.91, 95% CI [-49.76, 3.94], t(2038) = -1.67, p = 0.094; Std. beta = -1.64,
## 95% CI [-4.14, 0.86])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.75, 95% CI [-19.48, 3.98], t(2038) = -1.30, p = 0.195; Std. beta = -0.45,
## 95% CI [-1.26, 0.35])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.42, 95% CI [33.40, 87.44], t(2038) = 4.39, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.91])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-23.03, 15.53], t(2038) = -0.38, p = 0.703; Std. beta = -1.10,
## 95% CI [-3.50, 1.30])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.23, 95% CI [-16.32, 7.86], t(2038) = -0.69, p = 0.493; Std. beta = 0.09,
## 95% CI [-0.77, 0.96])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-13.22, 9.63], t(2038) = -0.31, p = 0.758; Std. beta = 0.19,
## 95% CI [-0.64, 1.01])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.87, 95% CI [-37.02, 13.28], t(2038) = -0.93, p = 0.355; Std. beta =
## -0.11, 95% CI [-1.69, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.05, 95% CI [-18.92, -1.17], t(2038) = -2.22, p = 0.027; Std. beta = -0.11,
## 95% CI [-0.75, 0.54])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.84, 95% CI [-30.26, -5.42], t(2038) = -2.82, p = 0.005; Std. beta = -1.11,
## 95% CI [-2.24, 0.02])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-7.16, 14.14], t(2038) = 0.64, p = 0.520; Std. beta = 0.15, 95%
## CI [-0.57, 0.86])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.50, 95% CI [-16.53, 7.54], t(2038) = -0.73, p = 0.464; Std. beta = -0.21,
## 95% CI [-1.03, 0.61])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.72, 95% CI [-32.32, -1.11], t(2038) = -2.10, p = 0.036; Std. beta = -1.91,
## 95% CI [-4.33, 0.52])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-24.59, 28.22], t(2038) = 0.13, p = 0.893; Std. beta = 0.05,
## 95% CI [-1.56, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.15, 95% CI [-10.66, 12.96], t(2038) = 0.19, p = 0.848; Std. beta = 0.39,
## 95% CI [-0.35, 1.14])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.89, 95% CI [-7.18, 20.96], t(2038) = 0.96, p = 0.337; Std. beta = 0.64, 95%
## CI [-0.33, 1.61])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-20.80, 5.75], t(2038) = -1.11, p = 0.266; Std. beta = -0.67,
## 95% CI [-1.64, 0.31])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-14.00, 6.83], t(2038) = -0.68, p = 0.500; Std. beta = 0.05,
## 95% CI [-0.65, 0.76])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.99, 4.14], t(2038) = -1.46, p = 0.146; Std. beta = 0.28,
## 95% CI [-0.83, 1.40])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-7.49, 16.21], t(2038) = 0.72, p = 0.471; Std. beta = 0.86, 95%
## CI [0.04, 1.68])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-10.23, 15.87], t(2038) = 0.42, p = 0.671; Std. beta = 0.20,
## 95% CI [-0.65, 1.05])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-9.74, 8.48], t(2038) = -0.14, p = 0.892; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-18.33, 34.85], t(2038) = 0.61, p = 0.543; Std. beta = -2.08,
## 95% CI [-4.19, 0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-15.80, 21.89], t(2038) = 0.32, p = 0.751; Std. beta = 0.70,
## 95% CI [-0.63, 2.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.11, 95% CI [-27.78, 3.57], t(2038) = -1.51, p = 0.130; Std. beta = -0.24,
## 95% CI [-1.57, 1.10])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-16.67, 1.08], t(2038) = -1.72, p = 0.085; Std. beta = -0.65,
## 95% CI [-1.69, 0.39])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically significant and
## positive (beta = 0.86, 95% CI [0.11, 1.61], t(2038) = 2.24, p = 0.025; Std.
## beta = 0.16, 95% CI [0.02, 0.30])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.53, 95% CI [-67.94, 4.89], t(2038) = -1.70, p = 0.090;
## Std. beta = -3.39, 95% CI [-7.30, 0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-10.09, 13.69], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.19, 95% CI [-1.08, 1.47])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-11.96, 12.73], t(2038) = 0.06, p = 0.951; Std.
## beta = 0.04, 95% CI [-1.29, 1.37])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-17.80, 11.76], t(2038) = -0.40, p = 0.689;
## Std. beta = -0.32, 95% CI [-1.91, 1.26])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-4.75, 15.16], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.56, 95% CI [-0.51, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-3.80, 2.88], t(2038) = -0.27, p = 0.787; Std.
## beta = -0.05, 95% CI [-0.41, 0.31])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-5.22, 11.54], t(2038) = 0.74, p = 0.460; Std.
## beta = 0.34, 95% CI [-0.56, 1.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-1.52, 4.48], t(2038) = 0.97, p = 0.334; Std.
## beta = 0.16, 95% CI [-0.16, 0.48])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.40, 6.71], t(2038) = 0.64, p = 0.521; Std.
## beta = 0.18, 95% CI [-0.37, 0.72])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.93], t(2038) = 2.58, p = 0.010; Std.
## beta = 0.48, 95% CI [0.12, 0.85])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.65, 95% CI [-2.15, 13.45], t(2038) = 1.42, p = 0.155; Std.
## beta = 0.61, 95% CI [-0.23, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-0.73, 5.38], t(2038) = 1.49, p = 0.135; Std.
## beta = 0.25, 95% CI [-0.08, 0.58])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-0.12, 7.30], t(2038) = 1.90, p = 0.058; Std.
## beta = 0.39, 95% CI [-0.01, 0.79])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-26.95, 5.30], t(2038) = -1.32, p = 0.188;
## Std. beta = -1.16, 95% CI [-2.90, 0.57])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.08, 95% CI [-0.13, 14.29], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.76, 95% CI [-0.01, 1.54])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.95, 95% CI [1.26, 12.64], t(2038) = 2.40, p = 0.017; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.43, 95% CI [-4.54, 11.39], t(2038) = 0.84, p = 0.399; Std.
## beta = 0.37, 95% CI [-0.49, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.31, 9.43], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.17, 95% CI [-0.68, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.06, 95% CI [-55.51, 37.39], t(2038) = -0.38, p = 0.702;
## Std. beta = -0.97, 95% CI [-5.97, 4.02])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-28.71, 26.74], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.11, 95% CI [-3.09, 2.87])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-4.59, 6.09], t(2038) = 0.27, p = 0.784; Std.
## beta = 0.08, 95% CI [-0.49, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.74, 95% CI [-34.23, 16.74], t(2038) = -0.67, p = 0.501;
## Std. beta = -0.94, 95% CI [-3.68, 1.80])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.91, 95% CI [-3.03, 10.84], t(2038) = 1.10, p = 0.269; Std.
## beta = 0.42, 95% CI [-0.33, 1.17])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-3.73, 10.06], t(2038) = 0.90, p = 0.369; Std.
## beta = 0.34, 95% CI [-0.40, 1.08])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-2.17, 16.49], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.77, 95% CI [-0.23, 1.77])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.90, 95% CI [0.33, 11.47], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-9.62, 11.60], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-6.25, 4.40], t(2038) = -0.34, p = 0.733; Std.
## beta = -0.10, 95% CI [-0.67, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-5.45, 7.39], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.00, 95% CI [-33.62, 17.62], t(2038) = -0.61, p = 0.540;
## Std. beta = -0.86, 95% CI [-3.61, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.82, 9.28], t(2038) = -0.15, p = 0.880; Std.
## beta = -0.08, 95% CI [-1.16, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.94, 7.44], t(2038) = 1.52, p = 0.128; Std.
## beta = 0.35, 95% CI [-0.10, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.62, 9.21], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-9.04, 5.76], t(2038) = -0.43, p = 0.664; Std.
## beta = -0.18, 95% CI [-0.97, 0.62])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 3.05, 95% CI [-1.93, 8.03], t(2038) = 1.20, p = 0.230; Std.
## beta = 0.33, 95% CI [-0.21, 0.86])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.24, 95% CI [1.90, 20.57], t(2038) = 2.36, p = 0.018; Std.
## beta = 1.21, 95% CI [0.20, 2.21])
## - The effect of time firstPFT × site [36R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.06, 11.61], t(2038) = 1.98, p = 0.047; Std.
## beta = 0.63, 95% CI [6.98e-03, 1.25])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-5.60, 5.83], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.01, 95% CI [-0.60, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-4.26, 3.80], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.02, 95% CI [-0.46, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.20, 95% CI [-47.78, -6.63], t(2038) = -2.59, p = 0.010;
## Std. beta = -2.92, 95% CI [-5.14, -0.71])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 5.06, 95% CI [-4.19, 14.32], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.54, 95% CI [-0.45, 1.54])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-7.21, 19.16], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.64, 95% CI [-0.77, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-12.97, 10.43], t(2038) = -0.21, p = 0.831;
## Std. beta = -0.14, 95% CI [-1.39, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.31. The model's intercept, corresponding to site =
## Simmons, is at 38.85 (95% CI [32.32, 45.38], t(2038) = 11.66, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -8.19, 95% CI [-11.65, -4.72], t(2038) = -4.64, p < .001; Std. beta = -0.64,
## 95% CI [-0.82, -0.46])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.40, 95% CI [-1.09, 1.89], t(2038) = 0.53, p = 0.599; Std. beta =
## 0.19, 95% CI [8.41e-03, 0.37])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-27.82, 26.57], t(2038) = -0.05, p = 0.964; Std. beta = -3.10,
## 95% CI [-6.33, 0.14])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.71, 95% CI [6.69, 46.73], t(2038) = 2.62, p = 0.009; Std. beta = 1.98, 95%
## CI [0.70, 3.26])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-23.02, 14.05], t(2038) = -0.47, p = 0.635; Std. beta = -0.27,
## 95% CI [-1.68, 1.15])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-27.63, 2.92], t(2038) = -1.59, p = 0.113; Std. beta = -1.13,
## 95% CI [-2.55, 0.29])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.68, 95% CI [-13.60, 24.97], t(2038) = 0.58, p = 0.563; Std. beta = 0.89,
## 95% CI [-0.46, 2.24])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.43, 95% CI [-1.58, 14.44], t(2038) = 1.58, p = 0.115; Std. beta = 0.39, 95%
## CI [-0.13, 0.91])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -7.41, 95% CI [-26.27, 11.46], t(2038) = -0.77, p = 0.441; Std. beta = -0.19,
## 95% CI [-1.46, 1.07])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.35, 95% CI [14.92, 27.78], t(2038) = 6.51, p < .001; Std. beta = 1.59, 95%
## CI [1.15, 2.03])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-0.61, 21.57], t(2038) = 1.85, p = 0.064; Std. beta = 0.87,
## 95% CI [0.13, 1.61])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-7.12, 6.57], t(2038) = -0.08, p = 0.937; Std. beta = 0.42,
## 95% CI [-0.06, 0.90])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-19.40, 3.80], t(2038) = -1.32, p = 0.187; Std. beta = 0.02,
## 95% CI [-0.90, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.54, 9.46], t(2038) = 0.89, p = 0.372; Std. beta = 0.43, 95%
## CI [-0.02, 0.87])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-10.14, 5.00], t(2038) = -0.67, p = 0.506; Std. beta = 0.17,
## 95% CI [-0.33, 0.68])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.75, 95% CI [-7.54, 31.04], t(2038) = 1.19, p = 0.233; Std. beta = -0.26,
## 95% CI [-1.84, 1.33])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -6.02, 95% CI [-21.76, 9.72], t(2038) = -0.75, p = 0.453; Std. beta = 0.28,
## 95% CI [-0.74, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.51, 95% CI [-22.01, 31.02], t(2038) = 0.33, p = 0.739; Std. beta = 0.30,
## 95% CI [-1.49, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.21, 16.77], t(2038) = 0.57, p = 0.568; Std. beta = 0.93, 95%
## CI [0.06, 1.80])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-26.46, 11.11], t(2038) = -0.80, p = 0.423; Std. beta = -0.19,
## 95% CI [-1.46, 1.08])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.06, 95% CI [-23.77, 5.66], t(2038) = -1.21, p = 0.227; Std. beta = -0.46,
## 95% CI [-1.42, 0.50])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-34.90, 24.34], t(2038) = -0.35, p = 0.727; Std. beta = -1.24,
## 95% CI [-4.41, 1.94])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.91, 95% CI [-49.76, 3.94], t(2038) = -1.67, p = 0.094; Std. beta = -1.64,
## 95% CI [-4.14, 0.86])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.75, 95% CI [-19.48, 3.98], t(2038) = -1.30, p = 0.195; Std. beta = -0.45,
## 95% CI [-1.26, 0.35])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.42, 95% CI [33.40, 87.44], t(2038) = 4.39, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.91])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-23.03, 15.53], t(2038) = -0.38, p = 0.703; Std. beta = -1.10,
## 95% CI [-3.50, 1.30])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.23, 95% CI [-16.32, 7.86], t(2038) = -0.69, p = 0.493; Std. beta = 0.09,
## 95% CI [-0.77, 0.96])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-13.22, 9.63], t(2038) = -0.31, p = 0.758; Std. beta = 0.19,
## 95% CI [-0.64, 1.01])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.87, 95% CI [-37.02, 13.28], t(2038) = -0.93, p = 0.355; Std. beta =
## -0.11, 95% CI [-1.69, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.05, 95% CI [-18.92, -1.17], t(2038) = -2.22, p = 0.027; Std. beta = -0.11,
## 95% CI [-0.75, 0.54])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.84, 95% CI [-30.26, -5.42], t(2038) = -2.82, p = 0.005; Std. beta = -1.11,
## 95% CI [-2.24, 0.02])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-7.16, 14.14], t(2038) = 0.64, p = 0.520; Std. beta = 0.15, 95%
## CI [-0.57, 0.86])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.50, 95% CI [-16.53, 7.54], t(2038) = -0.73, p = 0.464; Std. beta = -0.21,
## 95% CI [-1.03, 0.61])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.72, 95% CI [-32.32, -1.11], t(2038) = -2.10, p = 0.036; Std. beta = -1.91,
## 95% CI [-4.33, 0.52])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-24.59, 28.22], t(2038) = 0.13, p = 0.893; Std. beta = 0.05,
## 95% CI [-1.56, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.15, 95% CI [-10.66, 12.96], t(2038) = 0.19, p = 0.848; Std. beta = 0.39,
## 95% CI [-0.35, 1.14])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.89, 95% CI [-7.18, 20.96], t(2038) = 0.96, p = 0.337; Std. beta = 0.64, 95%
## CI [-0.33, 1.61])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-20.80, 5.75], t(2038) = -1.11, p = 0.266; Std. beta = -0.67,
## 95% CI [-1.64, 0.31])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-14.00, 6.83], t(2038) = -0.68, p = 0.500; Std. beta = 0.05,
## 95% CI [-0.65, 0.76])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.99, 4.14], t(2038) = -1.46, p = 0.146; Std. beta = 0.28,
## 95% CI [-0.83, 1.40])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-7.49, 16.21], t(2038) = 0.72, p = 0.471; Std. beta = 0.86, 95%
## CI [0.04, 1.68])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-10.23, 15.87], t(2038) = 0.42, p = 0.671; Std. beta = 0.20,
## 95% CI [-0.65, 1.05])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-9.74, 8.48], t(2038) = -0.14, p = 0.892; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-18.33, 34.85], t(2038) = 0.61, p = 0.543; Std. beta = -2.08,
## 95% CI [-4.19, 0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-15.80, 21.89], t(2038) = 0.32, p = 0.751; Std. beta = 0.70,
## 95% CI [-0.63, 2.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.11, 95% CI [-27.78, 3.57], t(2038) = -1.51, p = 0.130; Std. beta = -0.24,
## 95% CI [-1.57, 1.10])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-16.67, 1.08], t(2038) = -1.72, p = 0.085; Std. beta = -0.65,
## 95% CI [-1.69, 0.39])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically significant and
## positive (beta = 0.86, 95% CI [0.11, 1.61], t(2038) = 2.24, p = 0.025; Std.
## beta = 0.16, 95% CI [0.02, 0.30])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.53, 95% CI [-67.94, 4.89], t(2038) = -1.70, p = 0.090;
## Std. beta = -3.39, 95% CI [-7.30, 0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-10.09, 13.69], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.19, 95% CI [-1.08, 1.47])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-11.96, 12.73], t(2038) = 0.06, p = 0.951; Std.
## beta = 0.04, 95% CI [-1.29, 1.37])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-17.80, 11.76], t(2038) = -0.40, p = 0.689;
## Std. beta = -0.32, 95% CI [-1.91, 1.26])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-4.75, 15.16], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.56, 95% CI [-0.51, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-3.80, 2.88], t(2038) = -0.27, p = 0.787; Std.
## beta = -0.05, 95% CI [-0.41, 0.31])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-5.22, 11.54], t(2038) = 0.74, p = 0.460; Std.
## beta = 0.34, 95% CI [-0.56, 1.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-1.52, 4.48], t(2038) = 0.97, p = 0.334; Std.
## beta = 0.16, 95% CI [-0.16, 0.48])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.40, 6.71], t(2038) = 0.64, p = 0.521; Std.
## beta = 0.18, 95% CI [-0.37, 0.72])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.93], t(2038) = 2.58, p = 0.010; Std.
## beta = 0.48, 95% CI [0.12, 0.85])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.65, 95% CI [-2.15, 13.45], t(2038) = 1.42, p = 0.155; Std.
## beta = 0.61, 95% CI [-0.23, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-0.73, 5.38], t(2038) = 1.49, p = 0.135; Std.
## beta = 0.25, 95% CI [-0.08, 0.58])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-0.12, 7.30], t(2038) = 1.90, p = 0.058; Std.
## beta = 0.39, 95% CI [-0.01, 0.79])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-26.95, 5.30], t(2038) = -1.32, p = 0.188;
## Std. beta = -1.16, 95% CI [-2.90, 0.57])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.08, 95% CI [-0.13, 14.29], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.76, 95% CI [-0.01, 1.54])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.95, 95% CI [1.26, 12.64], t(2038) = 2.40, p = 0.017; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.43, 95% CI [-4.54, 11.39], t(2038) = 0.84, p = 0.399; Std.
## beta = 0.37, 95% CI [-0.49, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.31, 9.43], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.17, 95% CI [-0.68, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.06, 95% CI [-55.51, 37.39], t(2038) = -0.38, p = 0.702;
## Std. beta = -0.97, 95% CI [-5.97, 4.02])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-28.71, 26.74], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.11, 95% CI [-3.09, 2.87])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-4.59, 6.09], t(2038) = 0.27, p = 0.784; Std.
## beta = 0.08, 95% CI [-0.49, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.74, 95% CI [-34.23, 16.74], t(2038) = -0.67, p = 0.501;
## Std. beta = -0.94, 95% CI [-3.68, 1.80])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.91, 95% CI [-3.03, 10.84], t(2038) = 1.10, p = 0.269; Std.
## beta = 0.42, 95% CI [-0.33, 1.17])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-3.73, 10.06], t(2038) = 0.90, p = 0.369; Std.
## beta = 0.34, 95% CI [-0.40, 1.08])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-2.17, 16.49], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.77, 95% CI [-0.23, 1.77])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.90, 95% CI [0.33, 11.47], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-9.62, 11.60], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-6.25, 4.40], t(2038) = -0.34, p = 0.733; Std.
## beta = -0.10, 95% CI [-0.67, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-5.45, 7.39], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.00, 95% CI [-33.62, 17.62], t(2038) = -0.61, p = 0.540;
## Std. beta = -0.86, 95% CI [-3.61, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.82, 9.28], t(2038) = -0.15, p = 0.880; Std.
## beta = -0.08, 95% CI [-1.16, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.94, 7.44], t(2038) = 1.52, p = 0.128; Std.
## beta = 0.35, 95% CI [-0.10, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.62, 9.21], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-9.04, 5.76], t(2038) = -0.43, p = 0.664; Std.
## beta = -0.18, 95% CI [-0.97, 0.62])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 3.05, 95% CI [-1.93, 8.03], t(2038) = 1.20, p = 0.230; Std.
## beta = 0.33, 95% CI [-0.21, 0.86])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.24, 95% CI [1.90, 20.57], t(2038) = 2.36, p = 0.018; Std.
## beta = 1.21, 95% CI [0.20, 2.21])
## - The effect of time firstPFT × site [36R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.06, 11.61], t(2038) = 1.98, p = 0.047; Std.
## beta = 0.63, 95% CI [6.98e-03, 1.25])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-5.60, 5.83], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.01, 95% CI [-0.60, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-4.26, 3.80], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.02, 95% CI [-0.46, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.20, 95% CI [-47.78, -6.63], t(2038) = -2.59, p = 0.010;
## Std. beta = -2.92, 95% CI [-5.14, -0.71])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 5.06, 95% CI [-4.19, 14.32], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.54, 95% CI [-0.45, 1.54])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-7.21, 19.16], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.64, 95% CI [-0.77, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-12.97, 10.43], t(2038) = -0.21, p = 0.831;
## Std. beta = -0.14, 95% CI [-1.39, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.31. The model's intercept,
## corresponding to cohort = CARE-PF, is at 38.85 (95% CI [32.32, 45.38], t(2038)
## = 11.66, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -8.19, 95% CI [-11.65, -4.72], t(2038) = -4.64, p < .001; Std. beta = -0.64,
## 95% CI [-0.82, -0.46])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.40, 95% CI [-1.09, 1.89], t(2038) = 0.53, p = 0.599; Std. beta =
## 0.19, 95% CI [8.41e-03, 0.37])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-27.82, 26.57], t(2038) = -0.05, p = 0.964; Std. beta = -3.10,
## 95% CI [-6.33, 0.14])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.71, 95% CI [6.69, 46.73], t(2038) = 2.62, p = 0.009; Std. beta = 1.98, 95%
## CI [0.70, 3.26])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-23.02, 14.05], t(2038) = -0.47, p = 0.635; Std. beta = -0.27,
## 95% CI [-1.68, 1.15])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.36, 95% CI [-27.63, 2.92], t(2038) = -1.59, p = 0.113; Std. beta = -1.13,
## 95% CI [-2.55, 0.29])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.68, 95% CI [-13.60, 24.97], t(2038) = 0.58, p = 0.563; Std. beta = 0.89,
## 95% CI [-0.46, 2.24])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.43, 95% CI [-1.58, 14.44], t(2038) = 1.58, p = 0.115; Std. beta = 0.39, 95%
## CI [-0.13, 0.91])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -7.41, 95% CI [-26.27, 11.46], t(2038) = -0.77, p = 0.441; Std. beta = -0.19,
## 95% CI [-1.46, 1.07])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.35, 95% CI [14.92, 27.78], t(2038) = 6.51, p < .001; Std. beta = 1.59, 95%
## CI [1.15, 2.03])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.48, 95% CI [-0.61, 21.57], t(2038) = 1.85, p = 0.064; Std. beta = 0.87,
## 95% CI [0.13, 1.61])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.28, 95% CI [-7.12, 6.57], t(2038) = -0.08, p = 0.937; Std. beta = 0.42,
## 95% CI [-0.06, 0.90])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.80, 95% CI [-19.40, 3.80], t(2038) = -1.32, p = 0.187; Std. beta = 0.02,
## 95% CI [-0.90, 0.94])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-3.54, 9.46], t(2038) = 0.89, p = 0.372; Std. beta = 0.43, 95%
## CI [-0.02, 0.87])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-10.14, 5.00], t(2038) = -0.67, p = 0.506; Std. beta = 0.17,
## 95% CI [-0.33, 0.68])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.75, 95% CI [-7.54, 31.04], t(2038) = 1.19, p = 0.233; Std. beta = -0.26,
## 95% CI [-1.84, 1.33])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -6.02, 95% CI [-21.76, 9.72], t(2038) = -0.75, p = 0.453; Std. beta = 0.28,
## 95% CI [-0.74, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.51, 95% CI [-22.01, 31.02], t(2038) = 0.33, p = 0.739; Std. beta = 0.30,
## 95% CI [-1.49, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.78, 95% CI [-9.21, 16.77], t(2038) = 0.57, p = 0.568; Std. beta = 0.93, 95%
## CI [0.06, 1.80])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-26.46, 11.11], t(2038) = -0.80, p = 0.423; Std. beta = -0.19,
## 95% CI [-1.46, 1.08])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.06, 95% CI [-23.77, 5.66], t(2038) = -1.21, p = 0.227; Std. beta = -0.46,
## 95% CI [-1.42, 0.50])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-34.90, 24.34], t(2038) = -0.35, p = 0.727; Std. beta = -1.24,
## 95% CI [-4.41, 1.94])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.91, 95% CI [-49.76, 3.94], t(2038) = -1.67, p = 0.094; Std. beta = -1.64,
## 95% CI [-4.14, 0.86])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.75, 95% CI [-19.48, 3.98], t(2038) = -1.30, p = 0.195; Std. beta = -0.45,
## 95% CI [-1.26, 0.35])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.42, 95% CI [33.40, 87.44], t(2038) = 4.39, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.91])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-23.03, 15.53], t(2038) = -0.38, p = 0.703; Std. beta = -1.10,
## 95% CI [-3.50, 1.30])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.23, 95% CI [-16.32, 7.86], t(2038) = -0.69, p = 0.493; Std. beta = 0.09,
## 95% CI [-0.77, 0.96])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-13.22, 9.63], t(2038) = -0.31, p = 0.758; Std. beta = 0.19,
## 95% CI [-0.64, 1.01])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.87, 95% CI [-37.02, 13.28], t(2038) = -0.93, p = 0.355; Std. beta =
## -0.11, 95% CI [-1.69, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.05, 95% CI [-18.92, -1.17], t(2038) = -2.22, p = 0.027; Std. beta = -0.11,
## 95% CI [-0.75, 0.54])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.84, 95% CI [-30.26, -5.42], t(2038) = -2.82, p = 0.005; Std. beta = -1.11,
## 95% CI [-2.24, 0.02])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.49, 95% CI [-7.16, 14.14], t(2038) = 0.64, p = 0.520; Std. beta = 0.15, 95%
## CI [-0.57, 0.86])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.50, 95% CI [-16.53, 7.54], t(2038) = -0.73, p = 0.464; Std. beta = -0.21,
## 95% CI [-1.03, 0.61])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.72, 95% CI [-32.32, -1.11], t(2038) = -2.10, p = 0.036; Std. beta = -1.91,
## 95% CI [-4.33, 0.52])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-24.59, 28.22], t(2038) = 0.13, p = 0.893; Std. beta = 0.05,
## 95% CI [-1.56, 1.66])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 1.15, 95% CI [-10.66, 12.96], t(2038) = 0.19, p = 0.848; Std. beta = 0.39,
## 95% CI [-0.35, 1.14])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.89, 95% CI [-7.18, 20.96], t(2038) = 0.96, p = 0.337; Std. beta = 0.64, 95%
## CI [-0.33, 1.61])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-20.80, 5.75], t(2038) = -1.11, p = 0.266; Std. beta = -0.67,
## 95% CI [-1.64, 0.31])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-14.00, 6.83], t(2038) = -0.68, p = 0.500; Std. beta = 0.05,
## 95% CI [-0.65, 0.76])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.99, 4.14], t(2038) = -1.46, p = 0.146; Std. beta = 0.28,
## 95% CI [-0.83, 1.40])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-7.49, 16.21], t(2038) = 0.72, p = 0.471; Std. beta = 0.86, 95%
## CI [0.04, 1.68])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-10.23, 15.87], t(2038) = 0.42, p = 0.671; Std. beta = 0.20,
## 95% CI [-0.65, 1.05])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-9.74, 8.48], t(2038) = -0.14, p = 0.892; Std. beta = -0.06,
## 95% CI [-0.66, 0.54])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.26, 95% CI [-18.33, 34.85], t(2038) = 0.61, p = 0.543; Std. beta = -2.08,
## 95% CI [-4.19, 0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.05, 95% CI [-15.80, 21.89], t(2038) = 0.32, p = 0.751; Std. beta = 0.70,
## 95% CI [-0.63, 2.03])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.11, 95% CI [-27.78, 3.57], t(2038) = -1.51, p = 0.130; Std. beta = -0.24,
## 95% CI [-1.57, 1.10])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.79, 95% CI [-16.67, 1.08], t(2038) = -1.72, p = 0.085; Std. beta = -0.65,
## 95% CI [-1.69, 0.39])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically significant and
## positive (beta = 0.86, 95% CI [0.11, 1.61], t(2038) = 2.24, p = 0.025; Std.
## beta = 0.16, 95% CI [0.02, 0.30])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.53, 95% CI [-67.94, 4.89], t(2038) = -1.70, p = 0.090;
## Std. beta = -3.39, 95% CI [-7.30, 0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-10.09, 13.69], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.19, 95% CI [-1.08, 1.47])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## positive (beta = 0.39, 95% CI [-11.96, 12.73], t(2038) = 0.06, p = 0.951; Std.
## beta = 0.04, 95% CI [-1.29, 1.37])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.02, 95% CI [-17.80, 11.76], t(2038) = -0.40, p = 0.689;
## Std. beta = -0.32, 95% CI [-1.91, 1.26])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-4.75, 15.16], t(2038) = 1.03, p = 0.305; Std.
## beta = 0.56, 95% CI [-0.51, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-3.80, 2.88], t(2038) = -0.27, p = 0.787; Std.
## beta = -0.05, 95% CI [-0.41, 0.31])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-5.22, 11.54], t(2038) = 0.74, p = 0.460; Std.
## beta = 0.34, 95% CI [-0.56, 1.24])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.48, 95% CI [-1.52, 4.48], t(2038) = 0.97, p = 0.334; Std.
## beta = 0.16, 95% CI [-0.16, 0.48])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-3.40, 6.71], t(2038) = 0.64, p = 0.521; Std.
## beta = 0.18, 95% CI [-0.37, 0.72])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.51, 95% CI [1.09, 7.93], t(2038) = 2.58, p = 0.010; Std.
## beta = 0.48, 95% CI [0.12, 0.85])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.65, 95% CI [-2.15, 13.45], t(2038) = 1.42, p = 0.155; Std.
## beta = 0.61, 95% CI [-0.23, 1.45])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-0.73, 5.38], t(2038) = 1.49, p = 0.135; Std.
## beta = 0.25, 95% CI [-0.08, 0.58])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.59, 95% CI [-0.12, 7.30], t(2038) = 1.90, p = 0.058; Std.
## beta = 0.39, 95% CI [-0.01, 0.79])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-26.95, 5.30], t(2038) = -1.32, p = 0.188;
## Std. beta = -1.16, 95% CI [-2.90, 0.57])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.08, 95% CI [-0.13, 14.29], t(2038) = 1.93, p = 0.054; Std.
## beta = 0.76, 95% CI [-0.01, 1.54])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.95, 95% CI [1.26, 12.64], t(2038) = 2.40, p = 0.017; Std.
## beta = 0.75, 95% CI [0.14, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.43, 95% CI [-4.54, 11.39], t(2038) = 0.84, p = 0.399; Std.
## beta = 0.37, 95% CI [-0.49, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.31, 9.43], t(2038) = 0.39, p = 0.698; Std.
## beta = 0.17, 95% CI [-0.68, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.06, 95% CI [-55.51, 37.39], t(2038) = -0.38, p = 0.702;
## Std. beta = -0.97, 95% CI [-5.97, 4.02])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-28.71, 26.74], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.11, 95% CI [-3.09, 2.87])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.75, 95% CI [-4.59, 6.09], t(2038) = 0.27, p = 0.784; Std.
## beta = 0.08, 95% CI [-0.49, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.74, 95% CI [-34.23, 16.74], t(2038) = -0.67, p = 0.501;
## Std. beta = -0.94, 95% CI [-3.68, 1.80])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.91, 95% CI [-3.03, 10.84], t(2038) = 1.10, p = 0.269; Std.
## beta = 0.42, 95% CI [-0.33, 1.17])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 3.16, 95% CI [-3.73, 10.06], t(2038) = 0.90, p = 0.369; Std.
## beta = 0.34, 95% CI [-0.40, 1.08])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.16, 95% CI [-2.17, 16.49], t(2038) = 1.50, p = 0.133; Std.
## beta = 0.77, 95% CI [-0.23, 1.77])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.90, 95% CI [0.33, 11.47], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-9.62, 11.60], t(2038) = 0.18, p = 0.854; Std.
## beta = 0.11, 95% CI [-1.03, 1.25])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-6.25, 4.40], t(2038) = -0.34, p = 0.733; Std.
## beta = -0.10, 95% CI [-0.67, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-5.45, 7.39], t(2038) = 0.30, p = 0.767; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.00, 95% CI [-33.62, 17.62], t(2038) = -0.61, p = 0.540;
## Std. beta = -0.86, 95% CI [-3.61, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.82, 9.28], t(2038) = -0.15, p = 0.880; Std.
## beta = -0.08, 95% CI [-1.16, 1.00])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.25, 95% CI [-0.94, 7.44], t(2038) = 1.52, p = 0.128; Std.
## beta = 0.35, 95% CI [-0.10, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.62, 9.21], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-9.04, 5.76], t(2038) = -0.43, p = 0.664; Std.
## beta = -0.18, 95% CI [-0.97, 0.62])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 3.05, 95% CI [-1.93, 8.03], t(2038) = 1.20, p = 0.230; Std.
## beta = 0.33, 95% CI [-0.21, 0.86])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.24, 95% CI [1.90, 20.57], t(2038) = 2.36, p = 0.018; Std.
## beta = 1.21, 95% CI [0.20, 2.21])
## - The effect of time firstPFT × site [36R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.06, 11.61], t(2038) = 1.98, p = 0.047; Std.
## beta = 0.63, 95% CI [6.98e-03, 1.25])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.11, 95% CI [-5.60, 5.83], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.01, 95% CI [-0.60, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-4.26, 3.80], t(2038) = -0.11, p = 0.911; Std.
## beta = -0.02, 95% CI [-0.46, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.20, 95% CI [-47.78, -6.63], t(2038) = -2.59, p = 0.010;
## Std. beta = -2.92, 95% CI [-5.14, -0.71])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 5.06, 95% CI [-4.19, 14.32], t(2038) = 1.07, p = 0.284; Std.
## beta = 0.54, 95% CI [-0.45, 1.54])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.98, 95% CI [-7.21, 19.16], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.64, 95% CI [-0.77, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.27, 95% CI [-12.97, 10.43], t(2038) = -0.21, p = 0.831;
## Std. beta = -0.14, 95% CI [-1.39, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*SO4_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14681.1
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1224 -0.4946 -0.0103 0.4418 7.1071
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 139.04 11.792
## time_firstPFT 10.67 3.266 -0.29
## Residual 41.79 6.465
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 35.09448 6.30307 5.568
## time_firstPFT -6.83145 3.06428 -2.229
## SO4_5yrPreDx 0.62348 0.79623 0.783
## disadv -5.23708 2.36380 -2.216
## dich_RaceNon-White -3.39950 2.29724 -1.480
## sexF -2.58402 1.42902 -1.808
## age_dx 0.14063 0.07492 1.877
## smokeHxFormer -2.74979 1.41352 -1.945
## smokeHxAlways 9.66114 7.06021 1.368
## smokeHxUnknown -3.34550 3.20991 -1.042
## site02R -3.75124 13.76485 -0.273
## site03R 23.07059 10.22328 2.257
## site04R -3.62965 9.34788 -0.388
## site05R -12.67754 7.72900 -1.640
## site06R -6.72752 13.60251 -0.495
## site07R 4.97060 4.07323 1.220
## site09R -9.29603 9.55194 -0.973
## site101 21.99345 3.33722 6.590
## site102 10.01000 5.74979 1.741
## site103 0.61278 3.66103 0.167
## site104 -5.96523 5.93575 -1.005
## site105 4.01331 3.37481 1.189
## site106 -4.07776 3.92972 -1.038
## site107 9.76067 9.78191 0.998
## site108 0.25172 8.35853 0.030
## site10R 4.71925 13.48394 0.350
## site11R 2.87910 6.54282 0.440
## site12R -5.88122 9.46386 -0.621
## site13R -10.31424 7.48500 -1.378
## site14R -6.89561 15.06329 -0.458
## site15R -19.34128 13.57139 -1.425
## site16R -7.06538 6.03918 -1.170
## site17R 65.23915 13.79058 4.731
## site18R -2.01868 9.72388 -0.208
## site19R -4.21954 6.14446 -0.687
## site20R -1.72526 5.80553 -0.297
## site21R -11.37435 12.63626 -0.900
## site22R -12.35455 4.54760 -2.717
## site23R -23.72037 7.88099 -3.010
## site24R 3.36402 5.39565 0.623
## site25R -6.37735 6.17231 -1.033
## site28R -15.02438 7.92003 -1.897
## site29R -1.41550 13.35371 -0.106
## site31R 0.95338 6.07589 0.157
## site32R 7.75534 7.14244 1.086
## site33R -7.70191 6.72103 -1.146
## site34R -3.21669 5.26783 -0.611
## site35R -12.12498 8.12259 -1.493
## site36R 4.10088 5.99683 0.684
## site37R 1.44580 6.67977 0.216
## site38R 0.21852 4.61196 0.047
## site39R 17.16597 13.70497 1.253
## site40R 2.01125 9.49057 0.212
## site41R -12.31851 7.97740 -1.544
## site42R -9.44692 4.52929 -2.086
## time_firstPFT:SO4_5yrPreDx 0.72226 0.41389 1.745
## time_firstPFT:disadv 1.65060 1.10065 1.500
## time_firstPFT:dich_RaceNon-White -0.60584 1.09428 -0.554
## time_firstPFT:sexF 0.49788 0.65670 0.758
## time_firstPFT:age_dx -0.02564 0.03443 -0.745
## time_firstPFT:smokeHxFormer -0.58008 0.66608 -0.871
## time_firstPFT:smokeHxAlways -6.22558 6.01960 -1.034
## time_firstPFT:smokeHxUnknown 1.67600 1.66978 1.004
## time_firstPFT:site02R -30.52976 18.59589 -1.642
## time_firstPFT:site03R 1.70682 6.13758 0.278
## time_firstPFT:site04R -0.58540 6.35074 -0.092
## time_firstPFT:site05R -2.87440 7.55923 -0.380
## time_firstPFT:site07R -0.33016 1.75219 -0.188
## time_firstPFT:site09R 3.82128 4.31827 0.885
## time_firstPFT:site101 1.21527 1.57567 0.771
## time_firstPFT:site102 1.83310 2.67218 0.686
## time_firstPFT:site103 4.33734 1.86940 2.320
## time_firstPFT:site104 4.58485 4.06096 1.129
## time_firstPFT:site105 2.03619 1.61773 1.259
## time_firstPFT:site106 3.72272 1.95709 1.902
## time_firstPFT:site107 -10.37817 8.25014 -1.258
## time_firstPFT:site108 7.14835 3.88662 1.839
## time_firstPFT:site11R 7.14858 2.95362 2.420
## time_firstPFT:site12R 3.40106 4.09159 0.831
## time_firstPFT:site13R 1.36462 4.07806 0.335
## time_firstPFT:site14R -8.37899 23.70676 -0.353
## time_firstPFT:site15R -1.47010 14.15955 -0.104
## time_firstPFT:site16R 0.47620 2.82601 0.169
## time_firstPFT:site18R -9.12835 13.00618 -0.702
## time_firstPFT:site19R 3.38569 3.57320 0.948
## time_firstPFT:site20R 2.69943 3.59581 0.751
## time_firstPFT:site21R 7.30878 4.77641 1.530
## time_firstPFT:site22R 6.75796 2.89290 2.336
## time_firstPFT:site23R 24.31899 26.79905 0.907
## time_firstPFT:site24R -1.00037 2.75193 -0.364
## time_firstPFT:site25R 1.32687 3.35533 0.395
## time_firstPFT:site28R -7.09411 13.14440 -0.540
## time_firstPFT:site29R 0.35750 5.18367 0.069
## time_firstPFT:site31R 3.76584 2.23225 1.687
## time_firstPFT:site32R 1.65932 3.82846 0.433
## time_firstPFT:site33R -2.51818 3.84670 -0.655
## time_firstPFT:site34R 2.69227 2.57210 1.047
## time_firstPFT:site35R 11.27868 4.78812 2.356
## time_firstPFT:site36R 5.72550 2.97428 1.925
## time_firstPFT:site37R 0.24905 3.04644 0.082
## time_firstPFT:site38R -0.46071 2.08268 -0.221
## time_firstPFT:site39R -27.63949 10.59803 -2.608
## time_firstPFT:site40R 4.04931 4.79218 0.845
## time_firstPFT:site41R 6.20831 6.74829 0.920
## time_firstPFT:site42R -2.02932 5.98289 -0.339##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.789
## Unadjusted ICC: 0.532report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SO4_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to time_firstPFT = 0, is at 35.09 (95% CI [22.73, 47.46], t(2008)
## = 5.57, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SO4_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to SO4_5yrPreDx
## = 0, is at 35.09 (95% CI [22.73, 47.46], t(2008) = 5.57, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to disadv = 0, is at 35.09 (95% CI [22.73,
## 47.46], t(2008) = 5.57, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to dich_Race = White, is at 35.09 (95% CI
## [22.73, 47.46], t(2008) = 5.57, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to sex = M, is at 35.09 (95% CI [22.73,
## 47.46], t(2008) = 5.57, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to age_dx = 0, is at 35.09 (95% CI [22.73,
## 47.46], t(2008) = 5.57, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to smokeHx = Never, is at 35.09 (95% CI
## [22.73, 47.46], t(2008) = 5.57, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to site = Simmons, is at 35.09 (95% CI [22.73,
## 47.46], t(2008) = 5.57, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to cohort =
## CARE-PF, is at 35.09 (95% CI [22.73, 47.46], t(2008) = 5.57, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.83, 95% CI [-12.84, -0.82], t(2008) = -2.23, p = 0.026; Std. beta = -0.61,
## 95% CI [-0.83, -0.39])
## - The effect of SO4 5yrPreDx is statistically non-significant and positive
## (beta = 0.62, 95% CI [-0.94, 2.19], t(2008) = 0.78, p = 0.434; Std. beta =
## 0.19, 95% CI [7.72e-04, 0.39])
## - The effect of disadv is statistically significant and negative (beta = -5.24,
## 95% CI [-9.87, -0.60], t(2008) = -2.22, p = 0.027; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-7.90, 1.11], t(2008) = -1.48, p = 0.139; Std.
## beta = -0.29, 95% CI [-0.60, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.58, 95% CI [-5.39, 0.22], t(2008) = -1.81, p = 0.071; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.31e-03, 0.29], t(2008) = 1.88, p = 0.061; Std. beta = 0.06,
## 95% CI [-0.03, 0.15])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.24, 95% CI [-0.43, -0.05])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.66, 95% CI [-4.18, 23.51], t(2008) = 1.37, p = 0.171; Std. beta =
## 0.05, 95% CI [-1.15, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.35, 95% CI [-9.64, 2.95], t(2008) = -1.04, p = 0.297; Std. beta =
## -0.06, 95% CI [-0.52, 0.39])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.75, 95% CI [-30.75, 23.24], t(2008) = -0.27, p = 0.785; Std. beta = -3.22,
## 95% CI [-6.47, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.07, 95% CI [3.02, 43.12], t(2008) = 2.26, p = 0.024; Std. beta = 1.72, 95%
## CI [0.43, 3.02])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -3.63, 95% CI [-21.96, 14.70], t(2008) = -0.39, p = 0.698; Std. beta = -0.30,
## 95% CI [-1.72, 1.12])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.68, 95% CI [-27.84, 2.48], t(2008) = -1.64, p = 0.101; Std. beta = -1.14,
## 95% CI [-2.56, 0.29])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-33.40, 19.95], t(2008) = -0.49, p = 0.621; Std. beta = -0.45,
## 95% CI [-2.26, 1.35])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.97, 95% CI [-3.02, 12.96], t(2008) = 1.22, p = 0.222; Std. beta = 0.30, 95%
## CI [-0.22, 0.83])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-28.03, 9.44], t(2008) = -0.97, p = 0.331; Std. beta = -0.26,
## 95% CI [-1.53, 1.02])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.99, 95% CI [15.45, 28.54], t(2008) = 6.59, p < .001; Std. beta = 1.60, 95%
## CI [1.15, 2.05])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-1.27, 21.29], t(2008) = 1.74, p = 0.082; Std. beta = 0.85,
## 95% CI [0.10, 1.61])
## - The effect of site [103] is statistically non-significant and positive (beta
## = 0.61, 95% CI [-6.57, 7.79], t(2008) = 0.17, p = 0.867; Std. beta = 0.46, 95%
## CI [-0.04, 0.97])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-17.61, 5.68], t(2008) = -1.00, p = 0.315; Std. beta = 0.04,
## 95% CI [-0.89, 0.97])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 4.01, 95% CI [-2.61, 10.63], t(2008) = 1.19, p = 0.235; Std. beta = 0.47, 95%
## CI [0.01, 0.92])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-11.78, 3.63], t(2008) = -1.04, p = 0.300; Std. beta = 0.09,
## 95% CI [-0.43, 0.61])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.76, 95% CI [-9.42, 28.94], t(2008) = 1.00, p = 0.318; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [108] is statistically non-significant and positive (beta
## = 0.25, 95% CI [-16.14, 16.64], t(2008) = 0.03, p = 0.976; Std. beta = 0.71,
## 95% CI [-0.37, 1.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.72, 31.16], t(2008) = 0.35, p = 0.726; Std. beta = 0.32,
## 95% CI [-1.47, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.88, 95% CI [-9.95, 15.71], t(2008) = 0.44, p = 0.660; Std. beta = 0.89, 95%
## CI [0.02, 1.76])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -5.88, 95% CI [-24.44, 12.68], t(2008) = -0.62, p = 0.534; Std. beta = -0.07,
## 95% CI [-1.34, 1.20])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-24.99, 4.36], t(2008) = -1.38, p = 0.168; Std. beta = -0.56,
## 95% CI [-1.53, 0.40])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.90, 95% CI [-36.44, 22.65], t(2008) = -0.46, p = 0.647; Std. beta = -1.28,
## 95% CI [-4.47, 1.91])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.34, 95% CI [-45.96, 7.27], t(2008) = -1.43, p = 0.154; Std. beta = -1.45,
## 95% CI [-3.95, 1.06])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.07, 95% CI [-18.91, 4.78], t(2008) = -1.17, p = 0.242; Std. beta = -0.43,
## 95% CI [-1.25, 0.39])
## - The effect of site [17R] is statistically significant and positive (beta =
## 65.24, 95% CI [38.19, 92.28], t(2008) = 4.73, p < .001; Std. beta = 4.41, 95%
## CI [2.58, 6.23])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-21.09, 17.05], t(2008) = -0.21, p = 0.836; Std. beta = -1.02,
## 95% CI [-3.43, 1.38])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.22, 95% CI [-16.27, 7.83], t(2008) = -0.69, p = 0.492; Std. beta = 0.04,
## 95% CI [-0.83, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-13.11, 9.66], t(2008) = -0.30, p = 0.766; Std. beta = 0.15,
## 95% CI [-0.69, 0.98])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.37, 95% CI [-36.16, 13.41], t(2008) = -0.90, p = 0.368; Std. beta =
## -0.06, 95% CI [-1.62, 1.51])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.35, 95% CI [-21.27, -3.44], t(2008) = -2.72, p = 0.007; Std. beta = -0.18,
## 95% CI [-0.83, 0.48])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.72, 95% CI [-39.18, -8.26], t(2008) = -3.01, p = 0.003; Std. beta = 0.76,
## 95% CI [-3.93, 5.46])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.36, 95% CI [-7.22, 13.95], t(2008) = 0.62, p = 0.533; Std. beta = 0.13, 95%
## CI [-0.59, 0.85])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.38, 95% CI [-18.48, 5.73], t(2008) = -1.03, p = 0.302; Std. beta = -0.30,
## 95% CI [-1.14, 0.53])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.02, 95% CI [-30.56, 0.51], t(2008) = -1.90, p = 0.058; Std. beta = -1.70,
## 95% CI [-4.16, 0.75])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.42, 95% CI [-27.60, 24.77], t(2008) = -0.11, p = 0.916; Std. beta = -0.06,
## 95% CI [-1.67, 1.55])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.95, 95% CI [-10.96, 12.87], t(2008) = 0.16, p = 0.875; Std. beta = 0.43,
## 95% CI [-0.33, 1.19])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 7.76, 95% CI [-6.25, 21.76], t(2008) = 1.09, p = 0.278; Std. beta = 0.69, 95%
## CI [-0.29, 1.66])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.70, 95% CI [-20.88, 5.48], t(2008) = -1.15, p = 0.252; Std. beta = -0.77,
## 95% CI [-1.75, 0.22])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-13.55, 7.11], t(2008) = -0.61, p = 0.542; Std. beta = 0.04,
## 95% CI [-0.66, 0.75])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-28.05, 3.80], t(2008) = -1.49, p = 0.136; Std. beta = 0.28,
## 95% CI [-0.84, 1.39])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.10, 95% CI [-7.66, 15.86], t(2008) = 0.68, p = 0.494; Std. beta = 0.83, 95%
## CI [0.01, 1.65])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.45, 95% CI [-11.65, 14.55], t(2008) = 0.22, p = 0.829; Std. beta = 0.12,
## 95% CI [-0.74, 0.99])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-8.83, 9.26], t(2008) = 0.05, p = 0.962; Std. beta = -0.03, 95%
## CI [-0.63, 0.57])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 17.17, 95% CI [-9.71, 44.04], t(2008) = 1.25, p = 0.211; Std. beta = -1.53,
## 95% CI [-3.67, 0.61])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.01, 95% CI [-16.60, 20.62], t(2008) = 0.21, p = 0.832; Std. beta = 0.53,
## 95% CI [-0.80, 1.86])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.32, 95% CI [-27.96, 3.33], t(2008) = -1.54, p = 0.123; Std. beta = -0.23,
## 95% CI [-1.57, 1.11])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.45, 95% CI [-18.33, -0.56], t(2008) = -2.09, p = 0.037; Std. beta = -0.84,
## 95% CI [-1.89, 0.22])
## - The effect of time firstPFT × SO4 5yrPreDx is statistically non-significant
## and positive (beta = 0.72, 95% CI [-0.09, 1.53], t(2008) = 1.75, p = 0.081;
## Std. beta = 0.13, 95% CI [-0.02, 0.29])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.81], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-2.75, 1.54], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.50, 95% CI [-0.79, 1.79], t(2008) = 0.76, p = 0.448; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.74, p = 0.457; Std.
## beta = -0.03, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.89, 0.73], t(2008) =
## -0.87, p = 0.384; Std. beta = -0.06, 95% CI [-0.20, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.23, 95% CI [-18.03, 5.58], t(2008) =
## -1.03, p = 0.301; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.68, 95% CI [-1.60, 4.95], t(2008) =
## 1.00, p = 0.316; Std. beta = 0.18, 95% CI [-0.17, 0.53])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.53, 95% CI [-67.00, 5.94], t(2008) = -1.64, p = 0.101;
## Std. beta = -3.29, 95% CI [-7.21, 0.64])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-10.33, 13.74], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.18, 95% CI [-1.11, 1.48])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-13.04, 11.87], t(2008) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.40, 1.28])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-17.70, 11.95], t(2008) = -0.38, p = 0.704;
## Std. beta = -0.31, 95% CI [-1.91, 1.29])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-3.77, 3.11], t(2008) = -0.19, p = 0.851; Std.
## beta = -0.04, 95% CI [-0.41, 0.33])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-4.65, 12.29], t(2008) = 0.88, p = 0.376; Std.
## beta = 0.41, 95% CI [-0.50, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-1.87, 4.31], t(2008) = 0.77, p = 0.441; Std.
## beta = 0.13, 95% CI [-0.20, 0.46])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-3.41, 7.07], t(2008) = 0.69, p = 0.493; Std.
## beta = 0.20, 95% CI [-0.37, 0.76])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.34, 95% CI [0.67, 8.00], t(2008) = 2.32, p = 0.020; Std.
## beta = 0.47, 95% CI [0.07, 0.86])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.58, 95% CI [-3.38, 12.55], t(2008) = 1.13, p = 0.259; Std.
## beta = 0.49, 95% CI [-0.36, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-1.14, 5.21], t(2008) = 1.26, p = 0.208; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.72, 95% CI [-0.12, 7.56], t(2008) = 1.90, p = 0.057; Std.
## beta = 0.40, 95% CI [-0.01, 0.81])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.38, 95% CI [-26.56, 5.80], t(2008) = -1.26, p = 0.209;
## Std. beta = -1.12, 95% CI [-2.86, 0.62])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 7.15, 95% CI [-0.47, 14.77], t(2008) = 1.84, p = 0.066; Std.
## beta = 0.77, 95% CI [-0.05, 1.59])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.15, 95% CI [1.36, 12.94], t(2008) = 2.42, p = 0.016; Std.
## beta = 0.77, 95% CI [0.15, 1.39])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.62, 11.43], t(2008) = 0.83, p = 0.406; Std.
## beta = 0.37, 95% CI [-0.50, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.63, 9.36], t(2008) = 0.33, p = 0.738; Std.
## beta = 0.15, 95% CI [-0.71, 1.01])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.38, 95% CI [-54.87, 38.11], t(2008) = -0.35, p = 0.724;
## Std. beta = -0.90, 95% CI [-5.91, 4.10])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-29.24, 26.30], t(2008) = -0.10, p = 0.917;
## Std. beta = -0.16, 95% CI [-3.15, 2.83])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-5.07, 6.02], t(2008) = 0.17, p = 0.866; Std.
## beta = 0.05, 95% CI [-0.55, 0.65])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.13, 95% CI [-34.64, 16.38], t(2008) = -0.70, p = 0.483;
## Std. beta = -0.98, 95% CI [-3.73, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.39, 95% CI [-3.62, 10.39], t(2008) = 0.95, p = 0.343; Std.
## beta = 0.36, 95% CI [-0.39, 1.12])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.35, 9.75], t(2008) = 0.75, p = 0.453; Std.
## beta = 0.29, 95% CI [-0.47, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.31, 95% CI [-2.06, 16.68], t(2008) = 1.53, p = 0.126; Std.
## beta = 0.79, 95% CI [-0.22, 1.80])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.76, 95% CI [1.08, 12.43], t(2008) = 2.34, p = 0.020; Std.
## beta = 0.73, 95% CI [0.12, 1.34])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.32, 95% CI [-28.24, 76.88], t(2008) = 0.91, p = 0.364; Std.
## beta = 2.62, 95% CI [-3.04, 8.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.40, 4.40], t(2008) = -0.36, p = 0.716; Std.
## beta = -0.11, 95% CI [-0.69, 0.47])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-5.25, 7.91], t(2008) = 0.40, p = 0.693; Std.
## beta = 0.14, 95% CI [-0.57, 0.85])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.09, 95% CI [-32.87, 18.68], t(2008) = -0.54, p = 0.589;
## Std. beta = -0.76, 95% CI [-3.54, 2.01])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.36, 95% CI [-9.81, 10.52], t(2008) = 0.07, p = 0.945; Std.
## beta = 0.04, 95% CI [-1.06, 1.13])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.77, 95% CI [-0.61, 8.14], t(2008) = 1.69, p = 0.092; Std.
## beta = 0.41, 95% CI [-0.07, 0.88])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.66, 95% CI [-5.85, 9.17], t(2008) = 0.43, p = 0.665; Std.
## beta = 0.18, 95% CI [-0.63, 0.99])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-10.06, 5.03], t(2008) = -0.65, p = 0.513; Std.
## beta = -0.27, 95% CI [-1.08, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-2.35, 7.74], t(2008) = 1.05, p = 0.295; Std.
## beta = 0.29, 95% CI [-0.25, 0.83])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.28, 95% CI [1.89, 20.67], t(2008) = 2.36, p = 0.019; Std.
## beta = 1.21, 95% CI [0.20, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.73, 95% CI [-0.11, 11.56], t(2008) = 1.93, p = 0.054; Std.
## beta = 0.62, 95% CI [-0.01, 1.24])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## positive (beta = 0.25, 95% CI [-5.73, 6.22], t(2008) = 0.08, p = 0.935; Std.
## beta = 0.03, 95% CI [-0.62, 0.67])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.55, 3.62], t(2008) = -0.22, p = 0.825; Std.
## beta = -0.05, 95% CI [-0.49, 0.39])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -27.64, 95% CI [-48.42, -6.86], t(2008) = -2.61, p = 0.009;
## Std. beta = -2.98, 95% CI [-5.21, -0.74])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-5.35, 13.45], t(2008) = 0.84, p = 0.398; Std.
## beta = 0.44, 95% CI [-0.58, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-7.03, 19.44], t(2008) = 0.92, p = 0.358; Std.
## beta = 0.67, 95% CI [-0.76, 2.09])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-13.76, 9.70], t(2008) = -0.34, p = 0.735; Std.
## beta = -0.22, 95% CI [-1.48, 1.04])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*NO3_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14849.5
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1435 -0.4922 -0.0081 0.4342 7.0885
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 142.66 11.944
## time_firstPFT 10.80 3.286 -0.29
## Residual 41.74 6.460
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 44.74645 2.40595 18.598
## time_firstPFT -6.71336 1.23327 -5.444
## NO3_5yrPreDx -3.71860 1.87703 -1.981
## site02R -1.24133 13.56288 -0.092
## site03R 26.26351 9.87779 2.659
## site04R -1.90806 9.40799 -0.203
## site05R -11.98627 7.74983 -1.547
## site06R 3.98450 9.66725 0.412
## site07R 6.92798 3.73630 1.854
## site09R -9.66885 9.42222 -1.026
## site101 19.46717 2.54442 7.651
## site102 7.88076 4.96969 1.586
## site103 -4.42160 2.56938 -1.721
## site104 -12.64817 5.43802 -2.326
## site105 0.50464 2.57388 0.196
## site106 -3.66945 3.35726 -1.093
## site107 9.54375 9.59416 0.995
## site108 -10.53203 7.63455 -1.380
## site10R -1.11375 13.45696 -0.083
## site11R 0.05698 6.56116 0.009
## site12R -6.99374 9.35736 -0.747
## site13R -10.66215 7.29818 -1.461
## site14R -6.63038 14.96359 -0.443
## site15R -26.04933 13.68780 -1.903
## site16R -7.87809 5.86975 -1.342
## site17R 60.13195 13.62005 4.415
## site18R -6.92576 9.70128 -0.714
## site19R -9.28580 5.83663 -1.591
## site20R -1.96526 5.55430 -0.354
## site21R -14.59345 12.73460 -1.146
## site22R -10.38758 4.25354 -2.442
## site23R -20.21217 6.16458 -3.279
## site24R 4.69245 5.12960 0.915
## site25R -4.07276 5.61639 -0.725
## site28R -15.16392 7.94944 -1.908
## site29R -0.59721 13.30140 -0.045
## site31R -1.82168 5.87217 -0.310
## site32R 3.09994 6.76504 0.458
## site33R -10.32791 6.67334 -1.548
## site34R -5.27851 4.99407 -1.057
## site35R -15.63371 7.91339 -1.976
## site36R 5.32172 5.98333 0.889
## site37R 3.44197 6.50289 0.529
## site38R -3.62456 4.56717 -0.794
## site39R 4.72357 13.29296 0.355
## site40R 4.77406 9.38436 0.509
## site41R -12.71119 7.69864 -1.651
## site42R -8.19480 4.32468 -1.895
## time_firstPFT:NO3_5yrPreDx 1.97203 0.96536 2.043
## time_firstPFT:site02R -35.04986 18.51751 -1.893
## time_firstPFT:site03R -1.60046 5.92289 -0.270
## time_firstPFT:site04R -3.60731 6.29185 -0.573
## time_firstPFT:site05R -3.85768 7.54095 -0.512
## time_firstPFT:site06R 3.61826 5.02546 0.720
## time_firstPFT:site07R -3.33051 1.42016 -2.345
## time_firstPFT:site09R 1.33244 4.18479 0.318
## time_firstPFT:site101 -0.60728 1.06956 -0.568
## time_firstPFT:site102 -1.26022 2.15868 -0.584
## time_firstPFT:site103 2.63751 1.17057 2.253
## time_firstPFT:site104 3.95055 3.78258 1.044
## time_firstPFT:site105 0.39568 1.10118 0.359
## time_firstPFT:site106 1.51063 1.59666 0.946
## time_firstPFT:site107 -12.79776 8.14958 -1.570
## time_firstPFT:site108 5.31961 3.44828 1.543
## time_firstPFT:site11R 6.50982 2.88190 2.259
## time_firstPFT:site12R -0.30319 4.04306 -0.075
## time_firstPFT:site13R -0.27488 3.91454 -0.070
## time_firstPFT:site14R -10.94271 23.67347 -0.462
## time_firstPFT:site15R -0.58539 14.15426 -0.041
## time_firstPFT:site16R -1.08645 2.59675 -0.418
## time_firstPFT:site18R -9.58422 12.98239 -0.738
## time_firstPFT:site19R 2.71562 3.39205 0.801
## time_firstPFT:site20R 0.55083 3.37800 0.163
## time_firstPFT:site21R 6.49967 4.74831 1.369
## time_firstPFT:site22R 4.31342 2.75577 1.565
## time_firstPFT:site23R 0.29882 5.40258 0.055
## time_firstPFT:site24R -4.59406 2.50675 -1.833
## time_firstPFT:site25R -2.67881 2.95028 -0.908
## time_firstPFT:site28R -10.30106 13.07272 -0.788
## time_firstPFT:site29R -2.25689 5.05763 -0.446
## time_firstPFT:site31R 2.36275 2.02347 1.168
## time_firstPFT:site32R -0.25261 3.56563 -0.071
## time_firstPFT:site33R -2.13216 3.78062 -0.564
## time_firstPFT:site34R 1.15495 2.35343 0.491
## time_firstPFT:site35R 9.69057 4.63488 2.091
## time_firstPFT:site36R 3.98436 2.97177 1.341
## time_firstPFT:site37R -2.46557 2.86065 -0.862
## time_firstPFT:site38R -0.93722 1.97432 -0.475
## time_firstPFT:site39R -29.16177 10.42189 -2.798
## time_firstPFT:site40R 1.70283 4.54057 0.375
## time_firstPFT:site41R 3.30879 6.64294 0.498
## time_firstPFT:site42R -3.06029 5.92225 -0.517##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.792
## Unadjusted ICC: 0.534report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NO3_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.33. The model's
## intercept, corresponding to time_firstPFT = 0, is at 44.75 (95% CI [40.03,
## 49.46], t(2038) = 18.60, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.71, 95% CI [-9.13, -4.29], t(2038) = -5.44, p < .001; Std. beta = -0.51, 95%
## CI [-0.62, -0.40])
## - The effect of NO3 5yrPreDx is statistically significant and negative (beta =
## -3.72, 95% CI [-7.40, -0.04], t(2038) = -1.98, p = 0.048; Std. beta = -0.03,
## 95% CI [-0.15, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.24, 95% CI [-27.84, 25.36], t(2038) = -0.09, p = 0.927; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.26, 95% CI [6.89, 45.64], t(2038) = 2.66, p = 0.008; Std. beta = 1.62, 95%
## CI [0.38, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.36, 16.54], t(2038) = -0.20, p = 0.839; Std. beta = -0.48,
## 95% CI [-1.89, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-27.18, 3.21], t(2038) = -1.55, p = 0.122; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.98, 95% CI [-14.97, 22.94], t(2038) = 0.41, p = 0.680; Std. beta = 0.62,
## 95% CI [-0.72, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-0.40, 14.26], t(2038) = 1.85, p = 0.064; Std. beta = 0.15, 95%
## CI [-0.32, 0.61])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.67, 95% CI [-28.15, 8.81], t(2038) = -1.03, p = 0.305; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.48, 24.46], t(2038) = 7.65, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.88, 95% CI [-1.87, 17.63], t(2038) = 1.59, p = 0.113; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-9.46, 0.62], t(2038) = -1.72, p = 0.085; Std. beta = -0.04,
## 95% CI [-0.38, 0.30])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.65, 95% CI [-23.31, -1.98], t(2038) = -2.33, p = 0.020; Std. beta = -0.47,
## 95% CI [-1.33, 0.39])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-4.54, 5.55], t(2038) = 0.20, p = 0.845; Std. beta = 0.07, 95%
## CI [-0.26, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.67, 95% CI [-10.25, 2.91], t(2038) = -1.09, p = 0.275; Std. beta = -0.10,
## 95% CI [-0.53, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.54, 95% CI [-9.27, 28.36], t(2038) = 0.99, p = 0.320; Std. beta = -0.60,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-25.50, 4.44], t(2038) = -1.38, p = 0.168; Std. beta = -0.20,
## 95% CI [-1.16, 0.77])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-27.50, 25.28], t(2038) = -0.08, p = 0.934; Std. beta = -0.08,
## 95% CI [-1.86, 1.71])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-12.81, 12.92], t(2038) = 8.68e-03, p = 0.993; Std. beta =
## 0.63, 95% CI [-0.23, 1.50])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.99, 95% CI [-25.34, 11.36], t(2038) = -0.75, p = 0.455; Std. beta = -0.50,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.66, 95% CI [-24.97, 3.65], t(2038) = -1.46, p = 0.144; Std. beta = -0.75,
## 95% CI [-1.68, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-35.98, 22.72], t(2038) = -0.44, p = 0.658; Std. beta = -1.51,
## 95% CI [-4.68, 1.66])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.05, 95% CI [-52.89, 0.79], t(2038) = -1.90, p = 0.057; Std. beta = -1.82,
## 95% CI [-4.32, 0.69])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.88, 95% CI [-19.39, 3.63], t(2038) = -1.34, p = 0.180; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.13, 95% CI [33.42, 86.84], t(2038) = 4.41, p < .001; Std. beta = 4.07, 95%
## CI [2.26, 5.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.93, 95% CI [-25.95, 12.10], t(2038) = -0.71, p = 0.475; Std. beta = -1.40,
## 95% CI [-3.79, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-20.73, 2.16], t(2038) = -1.59, p = 0.112; Std. beta = -0.36,
## 95% CI [-1.19, 0.46])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.97, 95% CI [-12.86, 8.93], t(2038) = -0.35, p = 0.724; Std. beta = -0.08,
## 95% CI [-0.86, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.59, 95% CI [-39.57, 10.38], t(2038) = -1.15, p = 0.252; Std. beta =
## -0.36, 95% CI [-1.93, 1.22])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.39, 95% CI [-18.73, -2.05], t(2038) = -2.44, p = 0.015; Std. beta = -0.28,
## 95% CI [-0.90, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.21, 95% CI [-32.30, -8.12], t(2038) = -3.28, p = 0.001; Std. beta = -1.34,
## 95% CI [-2.46, -0.22])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-5.37, 14.75], t(2038) = 0.91, p = 0.360; Std. beta = -0.13,
## 95% CI [-0.80, 0.55])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-15.09, 6.94], t(2038) = -0.73, p = 0.468; Std. beta = -0.54,
## 95% CI [-1.28, 0.21])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.16, 95% CI [-30.75, 0.43], t(2038) = -1.91, p = 0.057; Std. beta = -2.02,
## 95% CI [-4.45, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-26.68, 25.49], t(2038) = -0.04, p = 0.964; Std. beta = -0.26,
## 95% CI [-1.85, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.82, 95% CI [-13.34, 9.69], t(2038) = -0.31, p = 0.756; Std. beta = 0.11,
## 95% CI [-0.62, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-10.17, 16.37], t(2038) = 0.46, p = 0.647; Std. beta = 0.19,
## 95% CI [-0.73, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2038) = -1.55, p = 0.122; Std. beta = -0.90,
## 95% CI [-1.88, 0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-15.07, 4.52], t(2038) = -1.06, p = 0.291; Std. beta = -0.24,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.63, 95% CI [-31.15, -0.11], t(2038) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-1.20, 0.96])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-6.41, 17.06], t(2038) = 0.89, p = 0.374; Std. beta = 0.75, 95%
## CI [-0.07, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-9.31, 16.19], t(2038) = 0.53, p = 0.597; Std. beta =
## -6.33e-03, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.62, 95% CI [-12.58, 5.33], t(2038) = -0.79, p = 0.428; Std. beta = -0.34,
## 95% CI [-0.92, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.35, 30.79], t(2038) = 0.36, p = 0.722; Std. beta = -2.51,
## 95% CI [-4.59, -0.43])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-13.63, 23.18], t(2038) = 0.51, p = 0.611; Std. beta = 0.49,
## 95% CI [-0.81, 1.78])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.71, 95% CI [-27.81, 2.39], t(2038) = -1.65, p = 0.099; Std. beta = -0.54,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-16.68, 0.29], t(2038) = -1.89, p = 0.058; Std. beta = -0.85,
## 95% CI [-1.88, 0.18])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically significant and
## positive (beta = 1.97, 95% CI [0.08, 3.87], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.10, 95% CI [3.88e-03, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.37, 1.27], t(2038) = -1.89, p = 0.059;
## Std. beta = -3.77, 95% CI [-7.67, 0.14])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-13.22, 10.02], t(2038) = -0.27, p = 0.787;
## Std. beta = -0.17, 95% CI [-1.42, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.61, 95% CI [-15.95, 8.73], t(2038) = -0.57, p = 0.566; Std.
## beta = -0.39, 95% CI [-1.71, 0.94])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.86, 95% CI [-18.65, 10.93], t(2038) = -0.51, p = 0.609;
## Std. beta = -0.41, 95% CI [-2.00, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-6.24, 13.47], t(2038) = 0.72, p = 0.472; Std.
## beta = 0.39, 95% CI [-0.67, 1.45])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.33, 95% CI [-6.12, -0.55], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.36, 95% CI [-0.66, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-6.87, 9.54], t(2038) = 0.32, p = 0.750; Std.
## beta = 0.14, 95% CI [-0.74, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.49], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-5.49, 2.97], t(2038) = -0.58, p = 0.559; Std.
## beta = -0.14, 95% CI [-0.59, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.64, 95% CI [0.34, 4.93], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.28, 95% CI [0.04, 0.53])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-3.47, 11.37], t(2038) = 1.04, p = 0.296; Std.
## beta = 0.42, 95% CI [-0.37, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-1.76, 2.56], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.04, 95% CI [-0.19, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-1.62, 4.64], t(2038) = 0.95, p = 0.344; Std.
## beta = 0.16, 95% CI [-0.17, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.80, 95% CI [-28.78, 3.18], t(2038) = -1.57, p = 0.116;
## Std. beta = -1.38, 95% CI [-3.09, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.32, 95% CI [-1.44, 12.08], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.57, 95% CI [-0.16, 1.30])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.51, 95% CI [0.86, 12.16], t(2038) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-8.23, 7.63], t(2038) = -0.07, p = 0.940; Std.
## beta = -0.03, 95% CI [-0.88, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-7.95, 7.40], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.85, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-57.37, 35.48], t(2038) = -0.46, p = 0.644;
## Std. beta = -1.18, 95% CI [-6.17, 3.81])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-28.34, 27.17], t(2038) = -0.04, p = 0.967;
## Std. beta = -0.06, 95% CI [-3.05, 2.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-6.18, 4.01], t(2038) = -0.42, p = 0.676; Std.
## beta = -0.12, 95% CI [-0.66, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-35.04, 15.88], t(2038) = -0.74, p = 0.460;
## Std. beta = -1.03, 95% CI [-3.77, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.94, 9.37], t(2038) = 0.80, p = 0.423; Std.
## beta = 0.29, 95% CI [-0.42, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-6.07, 7.18], t(2038) = 0.16, p = 0.870; Std.
## beta = 0.06, 95% CI [-0.65, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-2.81, 15.81], t(2038) = 1.37, p = 0.171; Std.
## beta = 0.70, 95% CI [-0.30, 1.70])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.31, 95% CI [-1.09, 9.72], t(2038) = 1.57, p = 0.118; Std.
## beta = 0.46, 95% CI [-0.12, 1.04])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.30, 95% CI [-10.30, 10.89], t(2038) = 0.06, p = 0.956; Std.
## beta = 0.03, 95% CI [-1.11, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.59, 95% CI [-9.51, 0.32], t(2038) = -1.83, p = 0.067; Std.
## beta = -0.49, 95% CI [-1.02, 0.03])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.68, 95% CI [-8.46, 3.11], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.29, 95% CI [-0.91, 0.33])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.30, 95% CI [-35.94, 15.34], t(2038) = -0.79, p = 0.431;
## Std. beta = -1.11, 95% CI [-3.86, 1.65])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-12.18, 7.66], t(2038) = -0.45, p = 0.655; Std.
## beta = -0.24, 95% CI [-1.31, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.61, 6.33], t(2038) = 1.17, p = 0.243; Std.
## beta = 0.25, 95% CI [-0.17, 0.68])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-7.25, 6.74], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.78, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-9.55, 5.28], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.23, 95% CI [-1.03, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.46, 5.77], t(2038) = 0.49, p = 0.624; Std.
## beta = 0.12, 95% CI [-0.37, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.69, 95% CI [0.60, 18.78], t(2038) = 2.09, p = 0.037; Std.
## beta = 1.04, 95% CI [0.06, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.98, 95% CI [-1.84, 9.81], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.43, 95% CI [-0.20, 1.05])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-8.08, 3.14], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.27, 95% CI [-0.87, 0.34])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-4.81, 2.93], t(2038) = -0.47, p = 0.635; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.16, 95% CI [-49.60, -8.72], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.14, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-7.20, 10.61], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.18, 95% CI [-0.77, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-9.72, 16.34], t(2038) = 0.50, p = 0.618; Std.
## beta = 0.36, 95% CI [-1.04, 1.76])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-14.67, 8.55], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.33, 95% CI [-1.58, 0.92])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NO3_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to NO3_5yrPreDx = 0, is at 44.75 (95% CI [40.03, 49.46], t(2038)
## = 18.60, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.71, 95% CI [-9.13, -4.29], t(2038) = -5.44, p < .001; Std. beta = -0.51, 95%
## CI [-0.62, -0.40])
## - The effect of NO3 5yrPreDx is statistically significant and negative (beta =
## -3.72, 95% CI [-7.40, -0.04], t(2038) = -1.98, p = 0.048; Std. beta = -0.03,
## 95% CI [-0.15, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.24, 95% CI [-27.84, 25.36], t(2038) = -0.09, p = 0.927; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.26, 95% CI [6.89, 45.64], t(2038) = 2.66, p = 0.008; Std. beta = 1.62, 95%
## CI [0.38, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.36, 16.54], t(2038) = -0.20, p = 0.839; Std. beta = -0.48,
## 95% CI [-1.89, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-27.18, 3.21], t(2038) = -1.55, p = 0.122; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.98, 95% CI [-14.97, 22.94], t(2038) = 0.41, p = 0.680; Std. beta = 0.62,
## 95% CI [-0.72, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-0.40, 14.26], t(2038) = 1.85, p = 0.064; Std. beta = 0.15, 95%
## CI [-0.32, 0.61])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.67, 95% CI [-28.15, 8.81], t(2038) = -1.03, p = 0.305; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.48, 24.46], t(2038) = 7.65, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.88, 95% CI [-1.87, 17.63], t(2038) = 1.59, p = 0.113; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-9.46, 0.62], t(2038) = -1.72, p = 0.085; Std. beta = -0.04,
## 95% CI [-0.38, 0.30])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.65, 95% CI [-23.31, -1.98], t(2038) = -2.33, p = 0.020; Std. beta = -0.47,
## 95% CI [-1.33, 0.39])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-4.54, 5.55], t(2038) = 0.20, p = 0.845; Std. beta = 0.07, 95%
## CI [-0.26, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.67, 95% CI [-10.25, 2.91], t(2038) = -1.09, p = 0.275; Std. beta = -0.10,
## 95% CI [-0.53, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.54, 95% CI [-9.27, 28.36], t(2038) = 0.99, p = 0.320; Std. beta = -0.60,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-25.50, 4.44], t(2038) = -1.38, p = 0.168; Std. beta = -0.20,
## 95% CI [-1.16, 0.77])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-27.50, 25.28], t(2038) = -0.08, p = 0.934; Std. beta = -0.08,
## 95% CI [-1.86, 1.71])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-12.81, 12.92], t(2038) = 8.68e-03, p = 0.993; Std. beta =
## 0.63, 95% CI [-0.23, 1.50])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.99, 95% CI [-25.34, 11.36], t(2038) = -0.75, p = 0.455; Std. beta = -0.50,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.66, 95% CI [-24.97, 3.65], t(2038) = -1.46, p = 0.144; Std. beta = -0.75,
## 95% CI [-1.68, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-35.98, 22.72], t(2038) = -0.44, p = 0.658; Std. beta = -1.51,
## 95% CI [-4.68, 1.66])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.05, 95% CI [-52.89, 0.79], t(2038) = -1.90, p = 0.057; Std. beta = -1.82,
## 95% CI [-4.32, 0.69])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.88, 95% CI [-19.39, 3.63], t(2038) = -1.34, p = 0.180; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.13, 95% CI [33.42, 86.84], t(2038) = 4.41, p < .001; Std. beta = 4.07, 95%
## CI [2.26, 5.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.93, 95% CI [-25.95, 12.10], t(2038) = -0.71, p = 0.475; Std. beta = -1.40,
## 95% CI [-3.79, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-20.73, 2.16], t(2038) = -1.59, p = 0.112; Std. beta = -0.36,
## 95% CI [-1.19, 0.46])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.97, 95% CI [-12.86, 8.93], t(2038) = -0.35, p = 0.724; Std. beta = -0.08,
## 95% CI [-0.86, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.59, 95% CI [-39.57, 10.38], t(2038) = -1.15, p = 0.252; Std. beta =
## -0.36, 95% CI [-1.93, 1.22])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.39, 95% CI [-18.73, -2.05], t(2038) = -2.44, p = 0.015; Std. beta = -0.28,
## 95% CI [-0.90, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.21, 95% CI [-32.30, -8.12], t(2038) = -3.28, p = 0.001; Std. beta = -1.34,
## 95% CI [-2.46, -0.22])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-5.37, 14.75], t(2038) = 0.91, p = 0.360; Std. beta = -0.13,
## 95% CI [-0.80, 0.55])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-15.09, 6.94], t(2038) = -0.73, p = 0.468; Std. beta = -0.54,
## 95% CI [-1.28, 0.21])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.16, 95% CI [-30.75, 0.43], t(2038) = -1.91, p = 0.057; Std. beta = -2.02,
## 95% CI [-4.45, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-26.68, 25.49], t(2038) = -0.04, p = 0.964; Std. beta = -0.26,
## 95% CI [-1.85, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.82, 95% CI [-13.34, 9.69], t(2038) = -0.31, p = 0.756; Std. beta = 0.11,
## 95% CI [-0.62, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-10.17, 16.37], t(2038) = 0.46, p = 0.647; Std. beta = 0.19,
## 95% CI [-0.73, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2038) = -1.55, p = 0.122; Std. beta = -0.90,
## 95% CI [-1.88, 0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-15.07, 4.52], t(2038) = -1.06, p = 0.291; Std. beta = -0.24,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.63, 95% CI [-31.15, -0.11], t(2038) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-1.20, 0.96])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-6.41, 17.06], t(2038) = 0.89, p = 0.374; Std. beta = 0.75, 95%
## CI [-0.07, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-9.31, 16.19], t(2038) = 0.53, p = 0.597; Std. beta =
## -6.33e-03, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.62, 95% CI [-12.58, 5.33], t(2038) = -0.79, p = 0.428; Std. beta = -0.34,
## 95% CI [-0.92, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.35, 30.79], t(2038) = 0.36, p = 0.722; Std. beta = -2.51,
## 95% CI [-4.59, -0.43])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-13.63, 23.18], t(2038) = 0.51, p = 0.611; Std. beta = 0.49,
## 95% CI [-0.81, 1.78])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.71, 95% CI [-27.81, 2.39], t(2038) = -1.65, p = 0.099; Std. beta = -0.54,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-16.68, 0.29], t(2038) = -1.89, p = 0.058; Std. beta = -0.85,
## 95% CI [-1.88, 0.18])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically significant and
## positive (beta = 1.97, 95% CI [0.08, 3.87], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.10, 95% CI [3.88e-03, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.37, 1.27], t(2038) = -1.89, p = 0.059;
## Std. beta = -3.77, 95% CI [-7.67, 0.14])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-13.22, 10.02], t(2038) = -0.27, p = 0.787;
## Std. beta = -0.17, 95% CI [-1.42, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.61, 95% CI [-15.95, 8.73], t(2038) = -0.57, p = 0.566; Std.
## beta = -0.39, 95% CI [-1.71, 0.94])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.86, 95% CI [-18.65, 10.93], t(2038) = -0.51, p = 0.609;
## Std. beta = -0.41, 95% CI [-2.00, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-6.24, 13.47], t(2038) = 0.72, p = 0.472; Std.
## beta = 0.39, 95% CI [-0.67, 1.45])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.33, 95% CI [-6.12, -0.55], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.36, 95% CI [-0.66, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-6.87, 9.54], t(2038) = 0.32, p = 0.750; Std.
## beta = 0.14, 95% CI [-0.74, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.49], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-5.49, 2.97], t(2038) = -0.58, p = 0.559; Std.
## beta = -0.14, 95% CI [-0.59, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.64, 95% CI [0.34, 4.93], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.28, 95% CI [0.04, 0.53])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-3.47, 11.37], t(2038) = 1.04, p = 0.296; Std.
## beta = 0.42, 95% CI [-0.37, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-1.76, 2.56], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.04, 95% CI [-0.19, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-1.62, 4.64], t(2038) = 0.95, p = 0.344; Std.
## beta = 0.16, 95% CI [-0.17, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.80, 95% CI [-28.78, 3.18], t(2038) = -1.57, p = 0.116;
## Std. beta = -1.38, 95% CI [-3.09, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.32, 95% CI [-1.44, 12.08], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.57, 95% CI [-0.16, 1.30])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.51, 95% CI [0.86, 12.16], t(2038) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-8.23, 7.63], t(2038) = -0.07, p = 0.940; Std.
## beta = -0.03, 95% CI [-0.88, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-7.95, 7.40], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.85, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-57.37, 35.48], t(2038) = -0.46, p = 0.644;
## Std. beta = -1.18, 95% CI [-6.17, 3.81])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-28.34, 27.17], t(2038) = -0.04, p = 0.967;
## Std. beta = -0.06, 95% CI [-3.05, 2.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-6.18, 4.01], t(2038) = -0.42, p = 0.676; Std.
## beta = -0.12, 95% CI [-0.66, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-35.04, 15.88], t(2038) = -0.74, p = 0.460;
## Std. beta = -1.03, 95% CI [-3.77, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.94, 9.37], t(2038) = 0.80, p = 0.423; Std.
## beta = 0.29, 95% CI [-0.42, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-6.07, 7.18], t(2038) = 0.16, p = 0.870; Std.
## beta = 0.06, 95% CI [-0.65, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-2.81, 15.81], t(2038) = 1.37, p = 0.171; Std.
## beta = 0.70, 95% CI [-0.30, 1.70])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.31, 95% CI [-1.09, 9.72], t(2038) = 1.57, p = 0.118; Std.
## beta = 0.46, 95% CI [-0.12, 1.04])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.30, 95% CI [-10.30, 10.89], t(2038) = 0.06, p = 0.956; Std.
## beta = 0.03, 95% CI [-1.11, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.59, 95% CI [-9.51, 0.32], t(2038) = -1.83, p = 0.067; Std.
## beta = -0.49, 95% CI [-1.02, 0.03])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.68, 95% CI [-8.46, 3.11], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.29, 95% CI [-0.91, 0.33])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.30, 95% CI [-35.94, 15.34], t(2038) = -0.79, p = 0.431;
## Std. beta = -1.11, 95% CI [-3.86, 1.65])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-12.18, 7.66], t(2038) = -0.45, p = 0.655; Std.
## beta = -0.24, 95% CI [-1.31, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.61, 6.33], t(2038) = 1.17, p = 0.243; Std.
## beta = 0.25, 95% CI [-0.17, 0.68])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-7.25, 6.74], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.78, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-9.55, 5.28], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.23, 95% CI [-1.03, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.46, 5.77], t(2038) = 0.49, p = 0.624; Std.
## beta = 0.12, 95% CI [-0.37, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.69, 95% CI [0.60, 18.78], t(2038) = 2.09, p = 0.037; Std.
## beta = 1.04, 95% CI [0.06, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.98, 95% CI [-1.84, 9.81], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.43, 95% CI [-0.20, 1.05])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-8.08, 3.14], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.27, 95% CI [-0.87, 0.34])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-4.81, 2.93], t(2038) = -0.47, p = 0.635; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.16, 95% CI [-49.60, -8.72], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.14, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-7.20, 10.61], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.18, 95% CI [-0.77, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-9.72, 16.34], t(2038) = 0.50, p = 0.618; Std.
## beta = 0.36, 95% CI [-1.04, 1.76])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-14.67, 8.55], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.33, 95% CI [-1.58, 0.92])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.33. The model's intercept, corresponding to site =
## Simmons, is at 44.75 (95% CI [40.03, 49.46], t(2038) = 18.60, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.71, 95% CI [-9.13, -4.29], t(2038) = -5.44, p < .001; Std. beta = -0.51, 95%
## CI [-0.62, -0.40])
## - The effect of NO3 5yrPreDx is statistically significant and negative (beta =
## -3.72, 95% CI [-7.40, -0.04], t(2038) = -1.98, p = 0.048; Std. beta = -0.03,
## 95% CI [-0.15, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.24, 95% CI [-27.84, 25.36], t(2038) = -0.09, p = 0.927; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.26, 95% CI [6.89, 45.64], t(2038) = 2.66, p = 0.008; Std. beta = 1.62, 95%
## CI [0.38, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.36, 16.54], t(2038) = -0.20, p = 0.839; Std. beta = -0.48,
## 95% CI [-1.89, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-27.18, 3.21], t(2038) = -1.55, p = 0.122; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.98, 95% CI [-14.97, 22.94], t(2038) = 0.41, p = 0.680; Std. beta = 0.62,
## 95% CI [-0.72, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-0.40, 14.26], t(2038) = 1.85, p = 0.064; Std. beta = 0.15, 95%
## CI [-0.32, 0.61])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.67, 95% CI [-28.15, 8.81], t(2038) = -1.03, p = 0.305; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.48, 24.46], t(2038) = 7.65, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.88, 95% CI [-1.87, 17.63], t(2038) = 1.59, p = 0.113; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-9.46, 0.62], t(2038) = -1.72, p = 0.085; Std. beta = -0.04,
## 95% CI [-0.38, 0.30])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.65, 95% CI [-23.31, -1.98], t(2038) = -2.33, p = 0.020; Std. beta = -0.47,
## 95% CI [-1.33, 0.39])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-4.54, 5.55], t(2038) = 0.20, p = 0.845; Std. beta = 0.07, 95%
## CI [-0.26, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.67, 95% CI [-10.25, 2.91], t(2038) = -1.09, p = 0.275; Std. beta = -0.10,
## 95% CI [-0.53, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.54, 95% CI [-9.27, 28.36], t(2038) = 0.99, p = 0.320; Std. beta = -0.60,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-25.50, 4.44], t(2038) = -1.38, p = 0.168; Std. beta = -0.20,
## 95% CI [-1.16, 0.77])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-27.50, 25.28], t(2038) = -0.08, p = 0.934; Std. beta = -0.08,
## 95% CI [-1.86, 1.71])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-12.81, 12.92], t(2038) = 8.68e-03, p = 0.993; Std. beta =
## 0.63, 95% CI [-0.23, 1.50])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.99, 95% CI [-25.34, 11.36], t(2038) = -0.75, p = 0.455; Std. beta = -0.50,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.66, 95% CI [-24.97, 3.65], t(2038) = -1.46, p = 0.144; Std. beta = -0.75,
## 95% CI [-1.68, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-35.98, 22.72], t(2038) = -0.44, p = 0.658; Std. beta = -1.51,
## 95% CI [-4.68, 1.66])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.05, 95% CI [-52.89, 0.79], t(2038) = -1.90, p = 0.057; Std. beta = -1.82,
## 95% CI [-4.32, 0.69])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.88, 95% CI [-19.39, 3.63], t(2038) = -1.34, p = 0.180; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.13, 95% CI [33.42, 86.84], t(2038) = 4.41, p < .001; Std. beta = 4.07, 95%
## CI [2.26, 5.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.93, 95% CI [-25.95, 12.10], t(2038) = -0.71, p = 0.475; Std. beta = -1.40,
## 95% CI [-3.79, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-20.73, 2.16], t(2038) = -1.59, p = 0.112; Std. beta = -0.36,
## 95% CI [-1.19, 0.46])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.97, 95% CI [-12.86, 8.93], t(2038) = -0.35, p = 0.724; Std. beta = -0.08,
## 95% CI [-0.86, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.59, 95% CI [-39.57, 10.38], t(2038) = -1.15, p = 0.252; Std. beta =
## -0.36, 95% CI [-1.93, 1.22])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.39, 95% CI [-18.73, -2.05], t(2038) = -2.44, p = 0.015; Std. beta = -0.28,
## 95% CI [-0.90, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.21, 95% CI [-32.30, -8.12], t(2038) = -3.28, p = 0.001; Std. beta = -1.34,
## 95% CI [-2.46, -0.22])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-5.37, 14.75], t(2038) = 0.91, p = 0.360; Std. beta = -0.13,
## 95% CI [-0.80, 0.55])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-15.09, 6.94], t(2038) = -0.73, p = 0.468; Std. beta = -0.54,
## 95% CI [-1.28, 0.21])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.16, 95% CI [-30.75, 0.43], t(2038) = -1.91, p = 0.057; Std. beta = -2.02,
## 95% CI [-4.45, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-26.68, 25.49], t(2038) = -0.04, p = 0.964; Std. beta = -0.26,
## 95% CI [-1.85, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.82, 95% CI [-13.34, 9.69], t(2038) = -0.31, p = 0.756; Std. beta = 0.11,
## 95% CI [-0.62, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-10.17, 16.37], t(2038) = 0.46, p = 0.647; Std. beta = 0.19,
## 95% CI [-0.73, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2038) = -1.55, p = 0.122; Std. beta = -0.90,
## 95% CI [-1.88, 0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-15.07, 4.52], t(2038) = -1.06, p = 0.291; Std. beta = -0.24,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.63, 95% CI [-31.15, -0.11], t(2038) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-1.20, 0.96])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-6.41, 17.06], t(2038) = 0.89, p = 0.374; Std. beta = 0.75, 95%
## CI [-0.07, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-9.31, 16.19], t(2038) = 0.53, p = 0.597; Std. beta =
## -6.33e-03, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.62, 95% CI [-12.58, 5.33], t(2038) = -0.79, p = 0.428; Std. beta = -0.34,
## 95% CI [-0.92, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.35, 30.79], t(2038) = 0.36, p = 0.722; Std. beta = -2.51,
## 95% CI [-4.59, -0.43])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-13.63, 23.18], t(2038) = 0.51, p = 0.611; Std. beta = 0.49,
## 95% CI [-0.81, 1.78])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.71, 95% CI [-27.81, 2.39], t(2038) = -1.65, p = 0.099; Std. beta = -0.54,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-16.68, 0.29], t(2038) = -1.89, p = 0.058; Std. beta = -0.85,
## 95% CI [-1.88, 0.18])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically significant and
## positive (beta = 1.97, 95% CI [0.08, 3.87], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.10, 95% CI [3.88e-03, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.37, 1.27], t(2038) = -1.89, p = 0.059;
## Std. beta = -3.77, 95% CI [-7.67, 0.14])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-13.22, 10.02], t(2038) = -0.27, p = 0.787;
## Std. beta = -0.17, 95% CI [-1.42, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.61, 95% CI [-15.95, 8.73], t(2038) = -0.57, p = 0.566; Std.
## beta = -0.39, 95% CI [-1.71, 0.94])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.86, 95% CI [-18.65, 10.93], t(2038) = -0.51, p = 0.609;
## Std. beta = -0.41, 95% CI [-2.00, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-6.24, 13.47], t(2038) = 0.72, p = 0.472; Std.
## beta = 0.39, 95% CI [-0.67, 1.45])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.33, 95% CI [-6.12, -0.55], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.36, 95% CI [-0.66, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-6.87, 9.54], t(2038) = 0.32, p = 0.750; Std.
## beta = 0.14, 95% CI [-0.74, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.49], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-5.49, 2.97], t(2038) = -0.58, p = 0.559; Std.
## beta = -0.14, 95% CI [-0.59, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.64, 95% CI [0.34, 4.93], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.28, 95% CI [0.04, 0.53])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-3.47, 11.37], t(2038) = 1.04, p = 0.296; Std.
## beta = 0.42, 95% CI [-0.37, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-1.76, 2.56], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.04, 95% CI [-0.19, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-1.62, 4.64], t(2038) = 0.95, p = 0.344; Std.
## beta = 0.16, 95% CI [-0.17, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.80, 95% CI [-28.78, 3.18], t(2038) = -1.57, p = 0.116;
## Std. beta = -1.38, 95% CI [-3.09, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.32, 95% CI [-1.44, 12.08], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.57, 95% CI [-0.16, 1.30])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.51, 95% CI [0.86, 12.16], t(2038) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-8.23, 7.63], t(2038) = -0.07, p = 0.940; Std.
## beta = -0.03, 95% CI [-0.88, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-7.95, 7.40], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.85, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-57.37, 35.48], t(2038) = -0.46, p = 0.644;
## Std. beta = -1.18, 95% CI [-6.17, 3.81])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-28.34, 27.17], t(2038) = -0.04, p = 0.967;
## Std. beta = -0.06, 95% CI [-3.05, 2.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-6.18, 4.01], t(2038) = -0.42, p = 0.676; Std.
## beta = -0.12, 95% CI [-0.66, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-35.04, 15.88], t(2038) = -0.74, p = 0.460;
## Std. beta = -1.03, 95% CI [-3.77, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.94, 9.37], t(2038) = 0.80, p = 0.423; Std.
## beta = 0.29, 95% CI [-0.42, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-6.07, 7.18], t(2038) = 0.16, p = 0.870; Std.
## beta = 0.06, 95% CI [-0.65, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-2.81, 15.81], t(2038) = 1.37, p = 0.171; Std.
## beta = 0.70, 95% CI [-0.30, 1.70])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.31, 95% CI [-1.09, 9.72], t(2038) = 1.57, p = 0.118; Std.
## beta = 0.46, 95% CI [-0.12, 1.04])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.30, 95% CI [-10.30, 10.89], t(2038) = 0.06, p = 0.956; Std.
## beta = 0.03, 95% CI [-1.11, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.59, 95% CI [-9.51, 0.32], t(2038) = -1.83, p = 0.067; Std.
## beta = -0.49, 95% CI [-1.02, 0.03])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.68, 95% CI [-8.46, 3.11], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.29, 95% CI [-0.91, 0.33])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.30, 95% CI [-35.94, 15.34], t(2038) = -0.79, p = 0.431;
## Std. beta = -1.11, 95% CI [-3.86, 1.65])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-12.18, 7.66], t(2038) = -0.45, p = 0.655; Std.
## beta = -0.24, 95% CI [-1.31, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.61, 6.33], t(2038) = 1.17, p = 0.243; Std.
## beta = 0.25, 95% CI [-0.17, 0.68])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-7.25, 6.74], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.78, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-9.55, 5.28], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.23, 95% CI [-1.03, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.46, 5.77], t(2038) = 0.49, p = 0.624; Std.
## beta = 0.12, 95% CI [-0.37, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.69, 95% CI [0.60, 18.78], t(2038) = 2.09, p = 0.037; Std.
## beta = 1.04, 95% CI [0.06, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.98, 95% CI [-1.84, 9.81], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.43, 95% CI [-0.20, 1.05])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-8.08, 3.14], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.27, 95% CI [-0.87, 0.34])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-4.81, 2.93], t(2038) = -0.47, p = 0.635; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.16, 95% CI [-49.60, -8.72], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.14, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-7.20, 10.61], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.18, 95% CI [-0.77, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-9.72, 16.34], t(2038) = 0.50, p = 0.618; Std.
## beta = 0.36, 95% CI [-1.04, 1.76])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-14.67, 8.55], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.33, 95% CI [-1.58, 0.92])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to cohort = CARE-PF, is at 44.75 (95% CI [40.03, 49.46], t(2038)
## = 18.60, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.71, 95% CI [-9.13, -4.29], t(2038) = -5.44, p < .001; Std. beta = -0.51, 95%
## CI [-0.62, -0.40])
## - The effect of NO3 5yrPreDx is statistically significant and negative (beta =
## -3.72, 95% CI [-7.40, -0.04], t(2038) = -1.98, p = 0.048; Std. beta = -0.03,
## 95% CI [-0.15, 0.09])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.24, 95% CI [-27.84, 25.36], t(2038) = -0.09, p = 0.927; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 26.26, 95% CI [6.89, 45.64], t(2038) = 2.66, p = 0.008; Std. beta = 1.62, 95%
## CI [0.38, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.36, 16.54], t(2038) = -0.20, p = 0.839; Std. beta = -0.48,
## 95% CI [-1.89, 0.93])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-27.18, 3.21], t(2038) = -1.55, p = 0.122; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.98, 95% CI [-14.97, 22.94], t(2038) = 0.41, p = 0.680; Std. beta = 0.62,
## 95% CI [-0.72, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-0.40, 14.26], t(2038) = 1.85, p = 0.064; Std. beta = 0.15, 95%
## CI [-0.32, 0.61])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.67, 95% CI [-28.15, 8.81], t(2038) = -1.03, p = 0.305; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.48, 24.46], t(2038) = 7.65, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.88, 95% CI [-1.87, 17.63], t(2038) = 1.59, p = 0.113; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-9.46, 0.62], t(2038) = -1.72, p = 0.085; Std. beta = -0.04,
## 95% CI [-0.38, 0.30])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.65, 95% CI [-23.31, -1.98], t(2038) = -2.33, p = 0.020; Std. beta = -0.47,
## 95% CI [-1.33, 0.39])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.50, 95% CI [-4.54, 5.55], t(2038) = 0.20, p = 0.845; Std. beta = 0.07, 95%
## CI [-0.26, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.67, 95% CI [-10.25, 2.91], t(2038) = -1.09, p = 0.275; Std. beta = -0.10,
## 95% CI [-0.53, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.54, 95% CI [-9.27, 28.36], t(2038) = 0.99, p = 0.320; Std. beta = -0.60,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.53, 95% CI [-25.50, 4.44], t(2038) = -1.38, p = 0.168; Std. beta = -0.20,
## 95% CI [-1.16, 0.77])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-27.50, 25.28], t(2038) = -0.08, p = 0.934; Std. beta = -0.08,
## 95% CI [-1.86, 1.71])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-12.81, 12.92], t(2038) = 8.68e-03, p = 0.993; Std. beta =
## 0.63, 95% CI [-0.23, 1.50])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.99, 95% CI [-25.34, 11.36], t(2038) = -0.75, p = 0.455; Std. beta = -0.50,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.66, 95% CI [-24.97, 3.65], t(2038) = -1.46, p = 0.144; Std. beta = -0.75,
## 95% CI [-1.68, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.63, 95% CI [-35.98, 22.72], t(2038) = -0.44, p = 0.658; Std. beta = -1.51,
## 95% CI [-4.68, 1.66])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.05, 95% CI [-52.89, 0.79], t(2038) = -1.90, p = 0.057; Std. beta = -1.82,
## 95% CI [-4.32, 0.69])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.88, 95% CI [-19.39, 3.63], t(2038) = -1.34, p = 0.180; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.13, 95% CI [33.42, 86.84], t(2038) = 4.41, p < .001; Std. beta = 4.07, 95%
## CI [2.26, 5.87])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.93, 95% CI [-25.95, 12.10], t(2038) = -0.71, p = 0.475; Std. beta = -1.40,
## 95% CI [-3.79, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-20.73, 2.16], t(2038) = -1.59, p = 0.112; Std. beta = -0.36,
## 95% CI [-1.19, 0.46])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.97, 95% CI [-12.86, 8.93], t(2038) = -0.35, p = 0.724; Std. beta = -0.08,
## 95% CI [-0.86, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.59, 95% CI [-39.57, 10.38], t(2038) = -1.15, p = 0.252; Std. beta =
## -0.36, 95% CI [-1.93, 1.22])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.39, 95% CI [-18.73, -2.05], t(2038) = -2.44, p = 0.015; Std. beta = -0.28,
## 95% CI [-0.90, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.21, 95% CI [-32.30, -8.12], t(2038) = -3.28, p = 0.001; Std. beta = -1.34,
## 95% CI [-2.46, -0.22])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 4.69, 95% CI [-5.37, 14.75], t(2038) = 0.91, p = 0.360; Std. beta = -0.13,
## 95% CI [-0.80, 0.55])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-15.09, 6.94], t(2038) = -0.73, p = 0.468; Std. beta = -0.54,
## 95% CI [-1.28, 0.21])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.16, 95% CI [-30.75, 0.43], t(2038) = -1.91, p = 0.057; Std. beta = -2.02,
## 95% CI [-4.45, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.60, 95% CI [-26.68, 25.49], t(2038) = -0.04, p = 0.964; Std. beta = -0.26,
## 95% CI [-1.85, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.82, 95% CI [-13.34, 9.69], t(2038) = -0.31, p = 0.756; Std. beta = 0.11,
## 95% CI [-0.62, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.10, 95% CI [-10.17, 16.37], t(2038) = 0.46, p = 0.647; Std. beta = 0.19,
## 95% CI [-0.73, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2038) = -1.55, p = 0.122; Std. beta = -0.90,
## 95% CI [-1.88, 0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.28, 95% CI [-15.07, 4.52], t(2038) = -1.06, p = 0.291; Std. beta = -0.24,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.63, 95% CI [-31.15, -0.11], t(2038) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-1.20, 0.96])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 5.32, 95% CI [-6.41, 17.06], t(2038) = 0.89, p = 0.374; Std. beta = 0.75, 95%
## CI [-0.07, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 3.44, 95% CI [-9.31, 16.19], t(2038) = 0.53, p = 0.597; Std. beta =
## -6.33e-03, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.62, 95% CI [-12.58, 5.33], t(2038) = -0.79, p = 0.428; Std. beta = -0.34,
## 95% CI [-0.92, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.72, 95% CI [-21.35, 30.79], t(2038) = 0.36, p = 0.722; Std. beta = -2.51,
## 95% CI [-4.59, -0.43])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.77, 95% CI [-13.63, 23.18], t(2038) = 0.51, p = 0.611; Std. beta = 0.49,
## 95% CI [-0.81, 1.78])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.71, 95% CI [-27.81, 2.39], t(2038) = -1.65, p = 0.099; Std. beta = -0.54,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-16.68, 0.29], t(2038) = -1.89, p = 0.058; Std. beta = -0.85,
## 95% CI [-1.88, 0.18])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically significant and
## positive (beta = 1.97, 95% CI [0.08, 3.87], t(2038) = 2.04, p = 0.041; Std.
## beta = 0.10, 95% CI [3.88e-03, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.37, 1.27], t(2038) = -1.89, p = 0.059;
## Std. beta = -3.77, 95% CI [-7.67, 0.14])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-13.22, 10.02], t(2038) = -0.27, p = 0.787;
## Std. beta = -0.17, 95% CI [-1.42, 1.08])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -3.61, 95% CI [-15.95, 8.73], t(2038) = -0.57, p = 0.566; Std.
## beta = -0.39, 95% CI [-1.71, 0.94])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.86, 95% CI [-18.65, 10.93], t(2038) = -0.51, p = 0.609;
## Std. beta = -0.41, 95% CI [-2.00, 1.18])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-6.24, 13.47], t(2038) = 0.72, p = 0.472; Std.
## beta = 0.39, 95% CI [-0.67, 1.45])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -3.33, 95% CI [-6.12, -0.55], t(2038) = -2.35, p = 0.019; Std.
## beta = -0.36, 95% CI [-0.66, -0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-6.87, 9.54], t(2038) = 0.32, p = 0.750; Std.
## beta = 0.14, 95% CI [-0.74, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.49], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-5.49, 2.97], t(2038) = -0.58, p = 0.559; Std.
## beta = -0.14, 95% CI [-0.59, 0.32])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.64, 95% CI [0.34, 4.93], t(2038) = 2.25, p = 0.024; Std.
## beta = 0.28, 95% CI [0.04, 0.53])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.95, 95% CI [-3.47, 11.37], t(2038) = 1.04, p = 0.296; Std.
## beta = 0.42, 95% CI [-0.37, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.40, 95% CI [-1.76, 2.56], t(2038) = 0.36, p = 0.719; Std.
## beta = 0.04, 95% CI [-0.19, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-1.62, 4.64], t(2038) = 0.95, p = 0.344; Std.
## beta = 0.16, 95% CI [-0.17, 0.50])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.80, 95% CI [-28.78, 3.18], t(2038) = -1.57, p = 0.116;
## Std. beta = -1.38, 95% CI [-3.09, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.32, 95% CI [-1.44, 12.08], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.57, 95% CI [-0.16, 1.30])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.51, 95% CI [0.86, 12.16], t(2038) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## negative (beta = -0.30, 95% CI [-8.23, 7.63], t(2038) = -0.07, p = 0.940; Std.
## beta = -0.03, 95% CI [-0.88, 0.82])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-7.95, 7.40], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.85, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.94, 95% CI [-57.37, 35.48], t(2038) = -0.46, p = 0.644;
## Std. beta = -1.18, 95% CI [-6.17, 3.81])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-28.34, 27.17], t(2038) = -0.04, p = 0.967;
## Std. beta = -0.06, 95% CI [-3.05, 2.92])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-6.18, 4.01], t(2038) = -0.42, p = 0.676; Std.
## beta = -0.12, 95% CI [-0.66, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-35.04, 15.88], t(2038) = -0.74, p = 0.460;
## Std. beta = -1.03, 95% CI [-3.77, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-3.94, 9.37], t(2038) = 0.80, p = 0.423; Std.
## beta = 0.29, 95% CI [-0.42, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.55, 95% CI [-6.07, 7.18], t(2038) = 0.16, p = 0.870; Std.
## beta = 0.06, 95% CI [-0.65, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.50, 95% CI [-2.81, 15.81], t(2038) = 1.37, p = 0.171; Std.
## beta = 0.70, 95% CI [-0.30, 1.70])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.31, 95% CI [-1.09, 9.72], t(2038) = 1.57, p = 0.118; Std.
## beta = 0.46, 95% CI [-0.12, 1.04])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 0.30, 95% CI [-10.30, 10.89], t(2038) = 0.06, p = 0.956; Std.
## beta = 0.03, 95% CI [-1.11, 1.17])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.59, 95% CI [-9.51, 0.32], t(2038) = -1.83, p = 0.067; Std.
## beta = -0.49, 95% CI [-1.02, 0.03])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.68, 95% CI [-8.46, 3.11], t(2038) = -0.91, p = 0.364; Std.
## beta = -0.29, 95% CI [-0.91, 0.33])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -10.30, 95% CI [-35.94, 15.34], t(2038) = -0.79, p = 0.431;
## Std. beta = -1.11, 95% CI [-3.86, 1.65])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-12.18, 7.66], t(2038) = -0.45, p = 0.655; Std.
## beta = -0.24, 95% CI [-1.31, 0.82])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.61, 6.33], t(2038) = 1.17, p = 0.243; Std.
## beta = 0.25, 95% CI [-0.17, 0.68])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.25, 95% CI [-7.25, 6.74], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.03, 95% CI [-0.78, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.13, 95% CI [-9.55, 5.28], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.23, 95% CI [-1.03, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.46, 5.77], t(2038) = 0.49, p = 0.624; Std.
## beta = 0.12, 95% CI [-0.37, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.69, 95% CI [0.60, 18.78], t(2038) = 2.09, p = 0.037; Std.
## beta = 1.04, 95% CI [0.06, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 3.98, 95% CI [-1.84, 9.81], t(2038) = 1.34, p = 0.180; Std.
## beta = 0.43, 95% CI [-0.20, 1.05])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-8.08, 3.14], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.27, 95% CI [-0.87, 0.34])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-4.81, 2.93], t(2038) = -0.47, p = 0.635; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.16, 95% CI [-49.60, -8.72], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.14, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.70, 95% CI [-7.20, 10.61], t(2038) = 0.38, p = 0.708; Std.
## beta = 0.18, 95% CI [-0.77, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-9.72, 16.34], t(2038) = 0.50, p = 0.618; Std.
## beta = 0.36, 95% CI [-1.04, 1.76])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.06, 95% CI [-14.67, 8.55], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.33, 95% CI [-1.58, 0.92])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*NO3_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14678.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1213 -0.4902 -0.0046 0.4366 7.0830
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 138.36 11.763
## time_firstPFT 10.80 3.286 -0.27
## Residual 41.78 6.464
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 41.41570 5.47799 7.560
## time_firstPFT -5.16471 2.50259 -2.064
## NO3_5yrPreDx -2.73005 1.90144 -1.436
## disadv -5.66510 2.32930 -2.432
## dich_RaceNon-White -2.70740 2.29274 -1.181
## sexF -2.30372 1.42865 -1.613
## age_dx 0.13026 0.07437 1.752
## smokeHxFormer -2.69855 1.41037 -1.913
## smokeHxAlways 9.27755 7.05097 1.316
## smokeHxUnknown -2.87840 3.17933 -0.905
## site02R -5.25805 13.47469 -0.390
## site03R 21.71496 9.88669 2.196
## site04R -2.43893 9.31613 -0.262
## site05R -12.56043 7.70602 -1.630
## site06R -8.57048 13.48536 -0.636
## site07R 4.75326 3.75159 1.267
## site09R -11.70387 9.36151 -1.250
## site101 19.70294 2.57094 7.664
## site102 6.90397 4.99217 1.383
## site103 -3.68407 2.70009 -1.364
## site104 -10.78622 5.44951 -1.979
## site105 1.29238 2.60190 0.497
## site106 -5.69741 3.40538 -1.673
## site107 7.28703 9.53089 0.765
## site108 -4.83715 7.95909 -0.608
## site10R 0.16753 13.44048 0.012
## site11R -0.30800 6.51177 -0.047
## site12R -6.15143 9.27072 -0.664
## site13R -12.14642 7.27130 -1.670
## site14R -8.65433 14.92875 -0.580
## site15R -21.99327 13.60942 -1.616
## site16R -7.83632 5.90248 -1.328
## site17R 63.86142 13.61122 4.692
## site18R -4.76815 9.63958 -0.495
## site19R -9.00640 5.82408 -1.546
## site20R -2.57655 5.51972 -0.467
## site21R -13.78889 12.58033 -1.096
## site22R -13.17089 4.29821 -3.064
## site23R -26.18422 7.71213 -3.395
## site24R 3.47632 5.10433 0.681
## site25R -7.15963 5.64082 -1.269
## site28R -14.27639 7.91644 -1.803
## site29R -3.94090 13.20678 -0.298
## site31R -2.17330 5.90291 -0.368
## site32R 3.87974 6.74806 0.575
## site33R -10.32248 6.64103 -1.554
## site34R -5.19935 4.95728 -1.049
## site35R -15.72241 7.87176 -1.997
## site36R 4.46102 5.95421 0.749
## site37R 1.30676 6.52699 0.200
## site38R -2.56102 4.54777 -0.563
## site39R 12.61784 13.42591 0.940
## site40R 2.58634 9.33446 0.277
## site41R -13.72721 7.68438 -1.786
## site42R -10.21811 4.34190 -2.353
## time_firstPFT:NO3_5yrPreDx 1.72615 1.00446 1.718
## time_firstPFT:disadv 1.34687 1.09548 1.229
## time_firstPFT:dich_RaceNon-White -0.79879 1.11226 -0.718
## time_firstPFT:sexF 0.47436 0.66316 0.715
## time_firstPFT:age_dx -0.03082 0.03434 -0.897
## time_firstPFT:smokeHxFormer -0.71731 0.66541 -1.078
## time_firstPFT:smokeHxAlways -6.17679 6.03122 -1.024
## time_firstPFT:smokeHxUnknown 2.10378 1.65634 1.270
## time_firstPFT:site02R -33.48854 18.54184 -1.806
## time_firstPFT:site03R -1.24542 5.96788 -0.209
## time_firstPFT:site04R -4.05672 6.33471 -0.640
## time_firstPFT:site05R -3.57244 7.55928 -0.473
## time_firstPFT:site07R -2.74137 1.48354 -1.848
## time_firstPFT:site09R 2.31343 4.21361 0.549
## time_firstPFT:site101 -0.44797 1.09094 -0.411
## time_firstPFT:site102 -0.63151 2.19107 -0.288
## time_firstPFT:site103 2.89273 1.25995 2.296
## time_firstPFT:site104 3.39569 3.85618 0.881
## time_firstPFT:site105 0.47305 1.11758 0.423
## time_firstPFT:site106 2.02930 1.64025 1.237
## time_firstPFT:site107 -12.06042 8.16358 -1.477
## time_firstPFT:site108 6.07855 3.67508 1.654
## time_firstPFT:site11R 6.89028 2.92393 2.357
## time_firstPFT:site12R 0.32830 4.09207 0.080
## time_firstPFT:site13R -0.28058 3.95048 -0.071
## time_firstPFT:site14R -9.88599 23.69252 -0.417
## time_firstPFT:site15R -0.87895 14.17881 -0.062
## time_firstPFT:site16R -1.12343 2.65605 -0.423
## time_firstPFT:site18R -9.64499 12.99654 -0.742
## time_firstPFT:site19R 2.62964 3.42881 0.767
## time_firstPFT:site20R 0.40968 3.42284 0.120
## time_firstPFT:site21R 6.90817 4.75837 1.452
## time_firstPFT:site22R 5.45393 2.80825 1.942
## time_firstPFT:site23R 24.72800 26.77161 0.924
## time_firstPFT:site24R -4.08420 2.53365 -1.612
## time_firstPFT:site25R -1.66736 3.00887 -0.554
## time_firstPFT:site28R -9.05007 13.14348 -0.689
## time_firstPFT:site29R -0.86174 5.09914 -0.169
## time_firstPFT:site31R 3.07562 2.08657 1.474
## time_firstPFT:site32R 0.15241 3.60775 0.042
## time_firstPFT:site33R -2.78842 3.84107 -0.726
## time_firstPFT:site34R 1.31895 2.39690 0.550
## time_firstPFT:site35R 10.30144 4.67868 2.202
## time_firstPFT:site36R 4.15909 3.00832 1.383
## time_firstPFT:site37R -1.94109 2.96003 -0.656
## time_firstPFT:site38R -0.96148 1.99144 -0.483
## time_firstPFT:site39R -28.92212 10.51670 -2.750
## time_firstPFT:site40R 1.36496 4.60283 0.297
## time_firstPFT:site41R 4.17449 6.66922 0.626
## time_firstPFT:site42R -3.44348 5.94485 -0.579##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.790
## Unadjusted ICC: 0.520report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NO3_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 41.42 (95% CI [30.67, 52.16], t(2008)
## = 7.56, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NO3_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to NO3_5yrPreDx
## = 0, is at 41.42 (95% CI [30.67, 52.16], t(2008) = 7.56, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to disadv = 0, is at 41.42 (95% CI [30.67,
## 52.16], t(2008) = 7.56, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to dich_Race = White, is at 41.42 (95% CI
## [30.67, 52.16], t(2008) = 7.56, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 41.42 (95% CI [30.67,
## 52.16], t(2008) = 7.56, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to age_dx = 0, is at 41.42 (95% CI [30.67,
## 52.16], t(2008) = 7.56, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to smokeHx = Never, is at 41.42 (95% CI
## [30.67, 52.16], t(2008) = 7.56, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 41.42 (95% CI [30.67,
## 52.16], t(2008) = 7.56, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 41.42 (95% CI [30.67, 52.16], t(2008) = 7.56, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.16, 95% CI [-10.07, -0.26], t(2008) = -2.06, p = 0.039; Std. beta = -0.50,
## 95% CI [-0.66, -0.34])
## - The effect of NO3 5yrPreDx is statistically non-significant and negative
## (beta = -2.73, 95% CI [-6.46, 1.00], t(2008) = -1.44, p = 0.151; Std. beta =
## -7.58e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.67,
## 95% CI [-10.23, -1.10], t(2008) = -2.43, p = 0.015; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-7.20, 1.79], t(2008) = -1.18, p = 0.238; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.11, 0.50], t(2008) = -1.61, p = 0.107; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.02, 0.28], t(2008) = 1.75, p = 0.080; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.70, 95% CI [-5.46, 0.07], t(2008) = -1.91, p = 0.056; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.28, 95% CI [-4.55, 23.11], t(2008) = 1.32, p = 0.188; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.11, 3.36], t(2008) = -0.91, p = 0.365; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.26, 95% CI [-31.68, 21.17], t(2008) = -0.39, p = 0.696; Std. beta = -3.61,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.71, 95% CI [2.33, 41.10], t(2008) = 2.20, p = 0.028; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-20.71, 15.83], t(2008) = -0.26, p = 0.794; Std. beta = -0.56,
## 95% CI [-1.98, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.56, 95% CI [-27.67, 2.55], t(2008) = -1.63, p = 0.103; Std. beta = -1.20,
## 95% CI [-2.62, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-35.02, 17.88], t(2008) = -0.64, p = 0.525; Std. beta = -0.58,
## 95% CI [-2.36, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-2.60, 12.11], t(2008) = 1.27, p = 0.205; Std. beta = 0.05, 95%
## CI [-0.42, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.70, 95% CI [-30.06, 6.66], t(2008) = -1.25, p = 0.211; Std. beta = -0.57,
## 95% CI [-1.82, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.70, 95% CI [14.66, 24.74], t(2008) = 7.66, p < .001; Std. beta = 1.29, 95%
## CI [0.95, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.90, 95% CI [-2.89, 16.69], t(2008) = 1.38, p = 0.167; Std. beta = 0.40, 95%
## CI [-0.24, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.68, 95% CI [-8.98, 1.61], t(2008) = -1.36, p = 0.173; Std. beta = 0.03,
## 95% CI [-0.33, 0.39])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.79, 95% CI [-21.47, -0.10], t(2008) = -1.98, p = 0.048; Std. beta = -0.40,
## 95% CI [-1.27, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.29, 95% CI [-3.81, 6.40], t(2008) = 0.50, p = 0.619; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.70, 95% CI [-12.38, 0.98], t(2008) = -1.67, p = 0.094; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.29, 95% CI [-11.40, 25.98], t(2008) = 0.76, p = 0.445; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-20.45, 10.77], t(2008) = -0.61, p = 0.543; Std. beta = 0.26,
## 95% CI [-0.76, 1.29])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.17, 95% CI [-26.19, 26.53], t(2008) = 0.01, p = 0.990; Std. beta = 0.01,
## 95% CI [-1.77, 1.79])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.31, 95% CI [-13.08, 12.46], t(2008) = -0.05, p = 0.962; Std. beta = 0.65,
## 95% CI [-0.22, 1.52])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.15, 95% CI [-24.33, 12.03], t(2008) = -0.66, p = 0.507; Std. beta = -0.38,
## 95% CI [-1.64, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.15, 95% CI [-26.41, 2.11], t(2008) = -1.67, p = 0.095; Std. beta = -0.85,
## 95% CI [-1.79, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.65, 95% CI [-37.93, 20.62], t(2008) = -0.58, p = 0.562; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.99, 95% CI [-48.68, 4.70], t(2008) = -1.62, p = 0.106; Std. beta = -1.57,
## 95% CI [-4.09, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-19.41, 3.74], t(2008) = -1.33, p = 0.184; Std. beta = -0.64,
## 95% CI [-1.44, 0.16])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.86, 95% CI [37.17, 90.56], t(2008) = 4.69, p < .001; Std. beta = 4.31, 95%
## CI [2.51, 6.12])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-23.67, 14.14], t(2008) = -0.49, p = 0.621; Std. beta = -1.26,
## 95% CI [-3.66, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-20.43, 2.42], t(2008) = -1.55, p = 0.122; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.58, 95% CI [-13.40, 8.25], t(2008) = -0.47, p = 0.641; Std. beta = -0.13,
## 95% CI [-0.92, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.79, 95% CI [-38.46, 10.88], t(2008) = -1.10, p = 0.273; Std. beta =
## -0.26, 95% CI [-1.83, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.17, 95% CI [-21.60, -4.74], t(2008) = -3.06, p = 0.002; Std. beta = -0.36,
## 95% CI [-0.98, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.18, 95% CI [-41.31, -11.06], t(2008) = -3.40, p < .001; Std. beta = 0.64,
## 95% CI [-4.05, 5.33])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.48, 95% CI [-6.53, 13.49], t(2008) = 0.68, p = 0.496; Std. beta = -0.16,
## 95% CI [-0.84, 0.51])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.22, 3.90], t(2008) = -1.27, p = 0.204; Std. beta = -0.65,
## 95% CI [-1.40, 0.11])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.28, 95% CI [-29.80, 1.25], t(2008) = -1.80, p = 0.071; Std. beta = -1.84,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.94, 95% CI [-29.84, 21.96], t(2008) = -0.30, p = 0.765; Std. beta = -0.35,
## 95% CI [-1.94, 1.24])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.17, 95% CI [-13.75, 9.40], t(2008) = -0.37, p = 0.713; Std. beta = 0.15,
## 95% CI [-0.58, 0.89])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.35, 17.11], t(2008) = 0.57, p = 0.565; Std. beta = 0.28, 95%
## CI [-0.65, 1.20])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-23.35, 2.70], t(2008) = -1.55, p = 0.120; Std. beta = -0.97,
## 95% CI [-1.95, 0.01])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.20, 95% CI [-14.92, 4.52], t(2008) = -1.05, p = 0.294; Std. beta = -0.22,
## 95% CI [-0.88, 0.44])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.72, 95% CI [-31.16, -0.28], t(2008) = -2.00, p = 0.046; Std. beta = -0.06,
## 95% CI [-1.14, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.46, 95% CI [-7.22, 16.14], t(2008) = 0.75, p = 0.454; Std. beta = 0.71, 95%
## CI [-0.12, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.31, 95% CI [-11.49, 14.11], t(2008) = 0.20, p = 0.841; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.56, 95% CI [-11.48, 6.36], t(2008) = -0.56, p = 0.573; Std. beta = -0.27,
## 95% CI [-0.86, 0.32])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.62, 95% CI [-13.71, 38.95], t(2008) = 0.94, p = 0.347; Std. beta = -1.96,
## 95% CI [-4.07, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.59, 95% CI [-15.72, 20.89], t(2008) = 0.28, p = 0.782; Std. beta = 0.31,
## 95% CI [-1.00, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.73, 95% CI [-28.80, 1.34], t(2008) = -1.79, p = 0.074; Std. beta = -0.52,
## 95% CI [-1.83, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.22, 95% CI [-18.73, -1.70], t(2008) = -2.35, p = 0.019; Std. beta = -1.02,
## 95% CI [-2.06, 0.01])
## - The effect of time firstPFT × NO3 5yrPreDx is statistically non-significant
## and positive (beta = 1.73, 95% CI [-0.24, 3.70], t(2008) = 1.72, p = 0.086;
## Std. beta = 0.09, 95% CI [-0.01, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.35, 95% CI [-0.80, 3.50], t(2008) = 1.23, p = 0.219; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.80, 95% CI [-2.98, 1.38], t(2008) =
## -0.72, p = 0.473; Std. beta = -0.09, 95% CI [-0.32, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-0.83, 1.77], t(2008) = 0.72, p = 0.475; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.90, p = 0.370; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.02, 0.59], t(2008) =
## -1.08, p = 0.281; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.18, 95% CI [-18.00, 5.65], t(2008) =
## -1.02, p = 0.306; Std. beta = -0.66, 95% CI [-1.94, 0.61])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.14, 5.35], t(2008) =
## 1.27, p = 0.204; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.49, 95% CI [-69.85, 2.87], t(2008) = -1.81, p = 0.071;
## Std. beta = -3.61, 95% CI [-7.52, 0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.25, 95% CI [-12.95, 10.46], t(2008) = -0.21, p = 0.835;
## Std. beta = -0.13, 95% CI [-1.39, 1.13])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -4.06, 95% CI [-16.48, 8.37], t(2008) = -0.64, p = 0.522; Std.
## beta = -0.44, 95% CI [-1.77, 0.90])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.57, 95% CI [-18.40, 11.25], t(2008) = -0.47, p = 0.637;
## Std. beta = -0.38, 95% CI [-1.98, 1.21])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.74, 95% CI [-5.65, 0.17], t(2008) = -1.85, p = 0.065; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.31, 95% CI [-5.95, 10.58], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.25, 95% CI [-0.64, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.59, 1.69], t(2008) = -0.41, p = 0.681; Std.
## beta = -0.05, 95% CI [-0.28, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-4.93, 3.67], t(2008) = -0.29, p = 0.773; Std.
## beta = -0.07, 95% CI [-0.53, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.89, 95% CI [0.42, 5.36], t(2008) = 2.30, p = 0.022; Std.
## beta = 0.31, 95% CI [0.05, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.40, 95% CI [-4.17, 10.96], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.37, 95% CI [-0.45, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.47, 95% CI [-1.72, 2.66], t(2008) = 0.42, p = 0.672; Std.
## beta = 0.05, 95% CI [-0.19, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.19, 5.25], t(2008) = 1.24, p = 0.216; Std.
## beta = 0.22, 95% CI [-0.13, 0.56])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.06, 95% CI [-28.07, 3.95], t(2008) = -1.48, p = 0.140;
## Std. beta = -1.30, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.08, 95% CI [-1.13, 13.29], t(2008) = 1.65, p = 0.098; Std.
## beta = 0.65, 95% CI [-0.12, 1.43])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 6.89, 95% CI [1.16, 12.62], t(2008) = 2.36, p = 0.019; Std.
## beta = 0.74, 95% CI [0.12, 1.36])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 0.33, 95% CI [-7.70, 8.35], t(2008) = 0.08, p = 0.936; Std.
## beta = 0.04, 95% CI [-0.83, 0.90])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-8.03, 7.47], t(2008) = -0.07, p = 0.943; Std.
## beta = -0.03, 95% CI [-0.86, 0.80])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.89, 95% CI [-56.35, 36.58], t(2008) = -0.42, p = 0.677;
## Std. beta = -1.06, 95% CI [-6.07, 3.94])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-28.69, 26.93], t(2008) = -0.06, p = 0.951;
## Std. beta = -0.09, 95% CI [-3.09, 2.90])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-6.33, 4.09], t(2008) = -0.42, p = 0.672; Std.
## beta = -0.12, 95% CI [-0.68, 0.44])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -9.64, 95% CI [-35.13, 15.84], t(2008) = -0.74, p = 0.458;
## Std. beta = -1.04, 95% CI [-3.78, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-4.09, 9.35], t(2008) = 0.77, p = 0.443; Std.
## beta = 0.28, 95% CI [-0.44, 1.01])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.41, 95% CI [-6.30, 7.12], t(2008) = 0.12, p = 0.905; Std.
## beta = 0.04, 95% CI [-0.68, 0.77])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.91, 95% CI [-2.42, 16.24], t(2008) = 1.45, p = 0.147; Std.
## beta = 0.74, 95% CI [-0.26, 1.75])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.45, 95% CI [-0.05, 10.96], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.59, 95% CI [-5.76e-03, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.73, 95% CI [-27.78, 77.23], t(2008) = 0.92, p = 0.356; Std.
## beta = 2.66, 95% CI [-2.99, 8.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -4.08, 95% CI [-9.05, 0.88], t(2008) = -1.61, p = 0.107; Std.
## beta = -0.44, 95% CI [-0.97, 0.10])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-7.57, 4.23], t(2008) = -0.55, p = 0.580; Std.
## beta = -0.18, 95% CI [-0.81, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.05, 95% CI [-34.83, 16.73], t(2008) = -0.69, p = 0.491;
## Std. beta = -0.97, 95% CI [-3.75, 1.80])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.86, 9.14], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.09, 95% CI [-1.17, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-1.02, 7.17], t(2008) = 1.47, p = 0.141; Std.
## beta = 0.33, 95% CI [-0.11, 0.77])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.92, 7.23], t(2008) = 0.04, p = 0.966; Std.
## beta = 0.02, 95% CI [-0.75, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-10.32, 4.74], t(2008) = -0.73, p = 0.468; Std.
## beta = -0.30, 95% CI [-1.11, 0.51])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-3.38, 6.02], t(2008) = 0.55, p = 0.582; Std.
## beta = 0.14, 95% CI [-0.36, 0.65])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.30, 95% CI [1.13, 19.48], t(2008) = 2.20, p = 0.028; Std.
## beta = 1.11, 95% CI [0.12, 2.10])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.16, 95% CI [-1.74, 10.06], t(2008) = 1.38, p = 0.167; Std.
## beta = 0.45, 95% CI [-0.19, 1.08])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.94, 95% CI [-7.75, 3.86], t(2008) = -0.66, p = 0.512; Std.
## beta = -0.21, 95% CI [-0.83, 0.42])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-4.87, 2.94], t(2008) = -0.48, p = 0.629; Std.
## beta = -0.10, 95% CI [-0.52, 0.32])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.92, 95% CI [-49.55, -8.30], t(2008) = -2.75, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.33, -0.89])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-7.66, 10.39], t(2008) = 0.30, p = 0.767; Std.
## beta = 0.15, 95% CI [-0.82, 1.12])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.17, 95% CI [-8.90, 17.25], t(2008) = 0.63, p = 0.531; Std.
## beta = 0.45, 95% CI [-0.96, 1.86])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.10, 8.22], t(2008) = -0.58, p = 0.562; Std.
## beta = -0.37, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*NH4_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14850.9
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1486 -0.4911 -0.0055 0.4327 7.1231
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 144.32 12.013
## time_firstPFT 10.62 3.258 -0.30
## Residual 41.75 6.461
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 40.2100 3.0781 13.063
## time_firstPFT -7.6284 1.6393 -4.653
## NH4_5yrPreDx 0.1747 1.8414 0.095
## site02R -1.7509 13.8359 -0.127
## site03R 25.6356 10.1155 2.534
## site04R -5.2672 9.3506 -0.563
## site05R -12.5106 7.7867 -1.607
## site06R 5.0113 9.8489 0.509
## site07R 5.6674 3.9158 1.447
## site09R -8.2018 9.5698 -0.857
## site101 20.4701 3.1293 6.541
## site102 9.3482 5.4643 1.711
## site103 -1.4334 3.3596 -0.427
## site104 -9.0330 5.8345 -1.548
## site105 2.0491 3.1628 0.648
## site106 -3.4021 3.7325 -0.911
## site107 10.8600 9.7994 1.108
## site108 -7.2319 7.9677 -0.908
## site10R 4.2967 13.6716 0.314
## site11R 3.1547 6.7712 0.466
## site12R -8.5940 9.4532 -0.909
## site13R -9.7502 7.4979 -1.300
## site14R -6.0136 15.0830 -0.399
## site15R -23.1858 13.7233 -1.690
## site16R -8.1692 5.9283 -1.378
## site17R 59.6989 13.7586 4.339
## site18R -4.4502 9.9060 -0.449
## site19R -5.3593 6.1438 -0.872
## site20R -2.5286 5.7320 -0.441
## site21R -12.4038 12.8766 -0.963
## site22R -10.7711 4.4159 -2.439
## site23R -18.4990 6.3822 -2.899
## site24R 2.5733 5.2073 0.494
## site25R -5.7096 5.8872 -0.970
## site28R -17.0169 7.9377 -2.144
## site29R 1.0265 13.4456 0.076
## site31R 0.5073 6.0686 0.084
## site32R 5.7746 7.1172 0.811
## site33R -8.0966 6.8156 -1.188
## site34R -4.3277 5.2412 -0.826
## site35R -12.9258 8.1688 -1.582
## site36R 3.9344 5.9927 0.657
## site37R 2.2204 6.5751 0.338
## site38R -1.1694 4.7328 -0.247
## site39R 7.0965 13.4549 0.527
## site40R 1.9469 9.4043 0.207
## site41R -12.9654 7.9435 -1.632
## site42R -8.3257 4.4792 -1.859
## time_firstPFT:NH4_5yrPreDx 1.9233 0.9317 2.064
## time_firstPFT:site02R -31.9729 18.5617 -1.723
## time_firstPFT:site03R 1.0970 6.0197 0.182
## time_firstPFT:site04R -0.5709 6.2523 -0.091
## time_firstPFT:site05R -3.2862 7.5358 -0.436
## time_firstPFT:site06R 5.0857 5.0887 0.999
## time_firstPFT:site07R -1.0924 1.5868 -0.688
## time_firstPFT:site09R 2.7595 4.2563 0.648
## time_firstPFT:site101 0.9852 1.4325 0.688
## time_firstPFT:site102 0.8326 2.4414 0.341
## time_firstPFT:site103 4.0338 1.6566 2.435
## time_firstPFT:site104 5.3432 3.9660 1.347
## time_firstPFT:site105 1.8216 1.4529 1.254
## time_firstPFT:site106 3.1425 1.8261 1.721
## time_firstPFT:site107 -11.2360 8.2090 -1.369
## time_firstPFT:site108 6.6377 3.6409 1.823
## time_firstPFT:site11R 7.3458 2.9959 2.452
## time_firstPFT:site12R 2.1868 3.9732 0.550
## time_firstPFT:site13R 1.3367 4.0147 0.333
## time_firstPFT:site14R -9.5746 23.6844 -0.404
## time_firstPFT:site15R -0.7132 14.1455 -0.050
## time_firstPFT:site16R 0.1347 2.6670 0.051
## time_firstPFT:site18R -8.5421 13.0129 -0.656
## time_firstPFT:site19R 3.5957 3.5265 1.020
## time_firstPFT:site20R 2.6971 3.4833 0.774
## time_firstPFT:site21R 7.3959 4.7985 1.541
## time_firstPFT:site22R 5.5325 2.8155 1.965
## time_firstPFT:site23R 1.2151 5.4526 0.223
## time_firstPFT:site24R -1.8565 2.5829 -0.719
## time_firstPFT:site25R 0.1048 3.1541 0.033
## time_firstPFT:site28R -8.4044 13.0679 -0.643
## time_firstPFT:site29R -1.1546 5.1104 -0.226
## time_firstPFT:site31R 3.2383 2.1709 1.492
## time_firstPFT:site32R 1.3547 3.7521 0.361
## time_firstPFT:site33R -1.5770 3.8050 -0.414
## time_firstPFT:site34R 2.5980 2.4943 1.042
## time_firstPFT:site35R 10.9387 4.7536 2.301
## time_firstPFT:site36R 5.2911 2.9230 1.810
## time_firstPFT:site37R -0.6036 2.8570 -0.211
## time_firstPFT:site38R -0.1424 2.1106 -0.067
## time_firstPFT:site39R -28.1073 10.4552 -2.688
## time_firstPFT:site40R 3.8579 4.6102 0.837
## time_firstPFT:site41R 5.5579 6.7076 0.829
## time_firstPFT:site42R -1.6709 5.9578 -0.280##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.792
## Unadjusted ICC: 0.542report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NH4_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.32. The model's
## intercept, corresponding to time_firstPFT = 0, is at 40.21 (95% CI [34.17,
## 46.25], t(2038) = 13.06, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.63, 95% CI [-10.84, -4.41], t(2038) = -4.65, p < .001; Std. beta = -0.61,
## 95% CI [-0.78, -0.45])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.17, 95% CI [-3.44, 3.79], t(2038) = 0.09, p = 0.924; Std. beta =
## 0.13, 95% CI [-0.04, 0.30])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.75, 95% CI [-28.88, 25.38], t(2038) = -0.13, p = 0.899; Std. beta = -3.22,
## 95% CI [-6.45, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.64, 95% CI [5.80, 45.47], t(2038) = 2.53, p = 0.011; Std. beta = 1.84, 95%
## CI [0.57, 3.11])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-23.60, 13.07], t(2038) = -0.56, p = 0.573; Std. beta = -0.41,
## 95% CI [-1.81, 0.99])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.78, 2.76], t(2038) = -1.61, p = 0.108; Std. beta = -1.16,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.01, 95% CI [-14.30, 24.33], t(2038) = 0.51, p = 0.611; Std. beta = 0.83,
## 95% CI [-0.52, 2.19])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.67, 95% CI [-2.01, 13.35], t(2038) = 1.45, p = 0.148; Std. beta = 0.28, 95%
## CI [-0.22, 0.78])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -8.20, 95% CI [-26.97, 10.57], t(2038) = -0.86, p = 0.392; Std. beta = -0.29,
## 95% CI [-1.55, 0.98])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.47, 95% CI [14.33, 26.61], t(2038) = 6.54, p < .001; Std. beta = 1.48, 95%
## CI [1.06, 1.90])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-1.37, 20.06], t(2038) = 1.71, p = 0.087; Std. beta = 0.71, 95%
## CI [3.67e-03, 1.42])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.43, 95% CI [-8.02, 5.16], t(2038) = -0.43, p = 0.670; Std. beta = 0.29,
## 95% CI [-0.16, 0.75])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-20.48, 2.41], t(2038) = -1.55, p = 0.122; Std. beta = -0.09,
## 95% CI [-1.00, 0.82])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-4.15, 8.25], t(2038) = 0.65, p = 0.517; Std. beta = 0.32, 95%
## CI [-0.11, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.40, 95% CI [-10.72, 3.92], t(2038) = -0.91, p = 0.362; Std. beta = 0.07,
## 95% CI [-0.41, 0.56])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-8.36, 30.08], t(2038) = 1.11, p = 0.268; Std. beta = -0.36,
## 95% CI [-1.94, 1.23])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-22.86, 8.39], t(2038) = -0.91, p = 0.364; Std. beta = 0.15,
## 95% CI [-0.86, 1.17])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.30, 95% CI [-22.52, 31.11], t(2038) = 0.31, p = 0.753; Std. beta = 0.29,
## 95% CI [-1.52, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.15, 95% CI [-10.12, 16.43], t(2038) = 0.47, p = 0.641; Std. beta = 0.93,
## 95% CI [0.03, 1.82])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.59, 95% CI [-27.13, 9.94], t(2038) = -0.91, p = 0.363; Std. beta = -0.37,
## 95% CI [-1.62, 0.89])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-24.45, 4.95], t(2038) = -1.30, p = 0.194; Std. beta = -0.53,
## 95% CI [-1.49, 0.43])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-35.59, 23.57], t(2038) = -0.40, p = 0.690; Std. beta = -1.33,
## 95% CI [-4.51, 1.84])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.19, 95% CI [-50.10, 3.73], t(2038) = -1.69, p = 0.091; Std. beta = -1.64,
## 95% CI [-4.14, 0.87])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-19.80, 3.46], t(2038) = -1.38, p = 0.168; Std. beta = -0.54,
## 95% CI [-1.34, 0.26])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.70, 95% CI [32.72, 86.68], t(2038) = 4.34, p < .001; Std. beta = 4.04, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-23.88, 14.98], t(2038) = -0.45, p = 0.653; Std. beta = -1.13,
## 95% CI [-3.54, 1.28])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-17.41, 6.69], t(2038) = -0.87, p = 0.383; Std. beta = -0.01,
## 95% CI [-0.88, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.53, 95% CI [-13.77, 8.71], t(2038) = -0.44, p = 0.659; Std. beta = 0.09,
## 95% CI [-0.72, 0.90])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.40, 95% CI [-37.66, 12.85], t(2038) = -0.96, p = 0.336; Std. beta =
## -0.12, 95% CI [-1.71, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.77, 95% CI [-19.43, -2.11], t(2038) = -2.44, p = 0.015; Std. beta = -0.19,
## 95% CI [-0.83, 0.44])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.50, 95% CI [-31.02, -5.98], t(2038) = -2.90, p = 0.004; Std. beta = -1.13,
## 95% CI [-2.27, 4.15e-03])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-7.64, 12.79], t(2038) = 0.49, p = 0.621; Std. beta =
## -6.01e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.71, 95% CI [-17.26, 5.84], t(2038) = -0.97, p = 0.332; Std. beta = -0.38,
## 95% CI [-1.16, 0.41])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.02, 95% CI [-32.58, -1.45], t(2038) = -2.14, p = 0.032; Std. beta = -1.97,
## 95% CI [-4.39, 0.46])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-25.34, 27.40], t(2038) = 0.08, p = 0.939; Std. beta = -0.04,
## 95% CI [-1.65, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-11.39, 12.41], t(2038) = 0.08, p = 0.933; Std. beta = 0.35,
## 95% CI [-0.41, 1.10])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-8.18, 19.73], t(2038) = 0.81, p = 0.417; Std. beta = 0.52, 95%
## CI [-0.44, 1.49])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -8.10, 95% CI [-21.46, 5.27], t(2038) = -1.19, p = 0.235; Std. beta = -0.70,
## 95% CI [-1.68, 0.28])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.33, 95% CI [-14.61, 5.95], t(2038) = -0.83, p = 0.409; Std. beta = -0.04,
## 95% CI [-0.74, 0.65])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.95, 3.09], t(2038) = -1.58, p = 0.114; Std. beta = 0.19,
## 95% CI [-0.93, 1.30])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.82, 15.69], t(2038) = 0.66, p = 0.512; Std. beta = 0.78, 95%
## CI [-0.04, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.67, 15.12], t(2038) = 0.34, p = 0.736; Std. beta = 0.09,
## 95% CI [-0.75, 0.93])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.17, 95% CI [-10.45, 8.11], t(2038) = -0.25, p = 0.805; Std. beta = -0.09,
## 95% CI [-0.71, 0.52])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.10, 95% CI [-19.29, 33.48], t(2038) = 0.53, p = 0.598; Std. beta = -2.25,
## 95% CI [-4.34, -0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-16.50, 20.39], t(2038) = 0.21, p = 0.836; Std. beta = 0.51,
## 95% CI [-0.80, 1.81])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.97, 95% CI [-28.54, 2.61], t(2038) = -1.63, p = 0.103; Std. beta = -0.34,
## 95% CI [-1.67, 0.99])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.33, 95% CI [-17.11, 0.46], t(2038) = -1.86, p = 0.063; Std. beta = -0.72,
## 95% CI [-1.76, 0.32])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically significant and
## positive (beta = 1.92, 95% CI [0.10, 3.75], t(2038) = 2.06, p = 0.039; Std.
## beta = 0.14, 95% CI [6.76e-03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.97, 95% CI [-68.37, 4.43], t(2038) = -1.72, p = 0.085;
## Std. beta = -3.44, 95% CI [-7.35, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.10, 95% CI [-10.71, 12.90], t(2038) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.15, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-12.83, 11.69], t(2038) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.06, 11.49], t(2038) = -0.44, p = 0.663;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-4.89, 15.07], t(2038) = 1.00, p = 0.318; Std.
## beta = 0.55, 95% CI [-0.53, 1.62])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-4.20, 2.02], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.12, 95% CI [-0.45, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.76, 95% CI [-5.59, 11.11], t(2038) = 0.65, p = 0.517; Std.
## beta = 0.30, 95% CI [-0.60, 1.19])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-1.82, 3.79], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.11, 95% CI [-0.20, 0.41])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.96, 5.62], t(2038) = 0.34, p = 0.733; Std.
## beta = 0.09, 95% CI [-0.43, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.03, 95% CI [0.79, 7.28], t(2038) = 2.44, p = 0.015; Std.
## beta = 0.43, 95% CI [0.08, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-2.43, 13.12], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.57, 95% CI [-0.26, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.03, 4.67], t(2038) = 1.25, p = 0.210; Std.
## beta = 0.20, 95% CI [-0.11, 0.50])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-0.44, 6.72], t(2038) = 1.72, p = 0.085; Std.
## beta = 0.34, 95% CI [-0.05, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.24, 95% CI [-27.33, 4.86], t(2038) = -1.37, p = 0.171;
## Std. beta = -1.21, 95% CI [-2.94, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-0.50, 13.78], t(2038) = 1.82, p = 0.068; Std.
## beta = 0.71, 95% CI [-0.05, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.35, 95% CI [1.47, 13.22], t(2038) = 2.45, p = 0.014; Std.
## beta = 0.79, 95% CI [0.16, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.61, 9.98], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.24, 95% CI [-0.60, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.54, 9.21], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.14, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-56.02, 36.87], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.03, 95% CI [-6.02, 3.96])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-28.45, 27.03], t(2038) = -0.05, p = 0.960;
## Std. beta = -0.08, 95% CI [-3.06, 2.91])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.13, 95% CI [-5.10, 5.37], t(2038) = 0.05, p = 0.960; Std.
## beta = 0.01, 95% CI [-0.55, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.54, 95% CI [-34.06, 16.98], t(2038) = -0.66, p = 0.512;
## Std. beta = -0.92, 95% CI [-3.66, 1.83])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.60, 95% CI [-3.32, 10.51], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.39, 95% CI [-0.36, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.13, 9.53], t(2038) = 0.77, p = 0.439; Std.
## beta = 0.29, 95% CI [-0.44, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.40, 95% CI [-2.01, 16.81], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.80, 95% CI [-0.22, 1.81])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.53, 95% CI [0.01, 11.05], t(2038) = 1.97, p = 0.050; Std.
## beta = 0.59, 95% CI [1.19e-03, 1.19])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-9.48, 11.91], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.02, 1.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-6.92, 3.21], t(2038) = -0.72, p = 0.472; Std.
## beta = -0.20, 95% CI [-0.74, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-6.08, 6.29], t(2038) = 0.03, p = 0.973; Std.
## beta = 0.01, 95% CI [-0.65, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.40, 95% CI [-34.03, 17.22], t(2038) = -0.64, p = 0.520;
## Std. beta = -0.90, 95% CI [-3.66, 1.85])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-11.18, 8.87], t(2038) = -0.23, p = 0.821; Std.
## beta = -0.12, 95% CI [-1.20, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-1.02, 7.50], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.35, 95% CI [-0.11, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-6.00, 8.71], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.15, 95% CI [-0.65, 0.94])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-9.04, 5.89], t(2038) = -0.41, p = 0.679; Std.
## beta = -0.17, 95% CI [-0.97, 0.63])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-2.29, 7.49], t(2038) = 1.04, p = 0.298; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.94, 95% CI [1.62, 20.26], t(2038) = 2.30, p = 0.021; Std.
## beta = 1.18, 95% CI [0.17, 2.18])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.29, 95% CI [-0.44, 11.02], t(2038) = 1.81, p = 0.070; Std.
## beta = 0.57, 95% CI [-0.05, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-6.21, 5.00], t(2038) = -0.21, p = 0.833; Std.
## beta = -0.06, 95% CI [-0.67, 0.54])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-4.28, 4.00], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.02, 95% CI [-0.46, 0.43])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.11, 95% CI [-48.61, -7.60], t(2038) = -2.69, p = 0.007;
## Std. beta = -3.02, 95% CI [-5.23, -0.82])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-5.18, 12.90], t(2038) = 0.84, p = 0.403; Std.
## beta = 0.41, 95% CI [-0.56, 1.39])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.56, 95% CI [-7.60, 18.71], t(2038) = 0.83, p = 0.407; Std.
## beta = 0.60, 95% CI [-0.82, 2.01])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-13.35, 10.01], t(2038) = -0.28, p = 0.779;
## Std. beta = -0.18, 95% CI [-1.44, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NH4_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to NH4_5yrPreDx = 0, is at 40.21 (95% CI [34.17, 46.25], t(2038)
## = 13.06, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.63, 95% CI [-10.84, -4.41], t(2038) = -4.65, p < .001; Std. beta = -0.61,
## 95% CI [-0.78, -0.45])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.17, 95% CI [-3.44, 3.79], t(2038) = 0.09, p = 0.924; Std. beta =
## 0.13, 95% CI [-0.04, 0.30])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.75, 95% CI [-28.88, 25.38], t(2038) = -0.13, p = 0.899; Std. beta = -3.22,
## 95% CI [-6.45, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.64, 95% CI [5.80, 45.47], t(2038) = 2.53, p = 0.011; Std. beta = 1.84, 95%
## CI [0.57, 3.11])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-23.60, 13.07], t(2038) = -0.56, p = 0.573; Std. beta = -0.41,
## 95% CI [-1.81, 0.99])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.78, 2.76], t(2038) = -1.61, p = 0.108; Std. beta = -1.16,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.01, 95% CI [-14.30, 24.33], t(2038) = 0.51, p = 0.611; Std. beta = 0.83,
## 95% CI [-0.52, 2.19])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.67, 95% CI [-2.01, 13.35], t(2038) = 1.45, p = 0.148; Std. beta = 0.28, 95%
## CI [-0.22, 0.78])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -8.20, 95% CI [-26.97, 10.57], t(2038) = -0.86, p = 0.392; Std. beta = -0.29,
## 95% CI [-1.55, 0.98])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.47, 95% CI [14.33, 26.61], t(2038) = 6.54, p < .001; Std. beta = 1.48, 95%
## CI [1.06, 1.90])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-1.37, 20.06], t(2038) = 1.71, p = 0.087; Std. beta = 0.71, 95%
## CI [3.67e-03, 1.42])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.43, 95% CI [-8.02, 5.16], t(2038) = -0.43, p = 0.670; Std. beta = 0.29,
## 95% CI [-0.16, 0.75])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-20.48, 2.41], t(2038) = -1.55, p = 0.122; Std. beta = -0.09,
## 95% CI [-1.00, 0.82])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-4.15, 8.25], t(2038) = 0.65, p = 0.517; Std. beta = 0.32, 95%
## CI [-0.11, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.40, 95% CI [-10.72, 3.92], t(2038) = -0.91, p = 0.362; Std. beta = 0.07,
## 95% CI [-0.41, 0.56])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-8.36, 30.08], t(2038) = 1.11, p = 0.268; Std. beta = -0.36,
## 95% CI [-1.94, 1.23])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-22.86, 8.39], t(2038) = -0.91, p = 0.364; Std. beta = 0.15,
## 95% CI [-0.86, 1.17])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.30, 95% CI [-22.52, 31.11], t(2038) = 0.31, p = 0.753; Std. beta = 0.29,
## 95% CI [-1.52, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.15, 95% CI [-10.12, 16.43], t(2038) = 0.47, p = 0.641; Std. beta = 0.93,
## 95% CI [0.03, 1.82])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.59, 95% CI [-27.13, 9.94], t(2038) = -0.91, p = 0.363; Std. beta = -0.37,
## 95% CI [-1.62, 0.89])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-24.45, 4.95], t(2038) = -1.30, p = 0.194; Std. beta = -0.53,
## 95% CI [-1.49, 0.43])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-35.59, 23.57], t(2038) = -0.40, p = 0.690; Std. beta = -1.33,
## 95% CI [-4.51, 1.84])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.19, 95% CI [-50.10, 3.73], t(2038) = -1.69, p = 0.091; Std. beta = -1.64,
## 95% CI [-4.14, 0.87])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-19.80, 3.46], t(2038) = -1.38, p = 0.168; Std. beta = -0.54,
## 95% CI [-1.34, 0.26])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.70, 95% CI [32.72, 86.68], t(2038) = 4.34, p < .001; Std. beta = 4.04, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-23.88, 14.98], t(2038) = -0.45, p = 0.653; Std. beta = -1.13,
## 95% CI [-3.54, 1.28])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-17.41, 6.69], t(2038) = -0.87, p = 0.383; Std. beta = -0.01,
## 95% CI [-0.88, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.53, 95% CI [-13.77, 8.71], t(2038) = -0.44, p = 0.659; Std. beta = 0.09,
## 95% CI [-0.72, 0.90])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.40, 95% CI [-37.66, 12.85], t(2038) = -0.96, p = 0.336; Std. beta =
## -0.12, 95% CI [-1.71, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.77, 95% CI [-19.43, -2.11], t(2038) = -2.44, p = 0.015; Std. beta = -0.19,
## 95% CI [-0.83, 0.44])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.50, 95% CI [-31.02, -5.98], t(2038) = -2.90, p = 0.004; Std. beta = -1.13,
## 95% CI [-2.27, 4.15e-03])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-7.64, 12.79], t(2038) = 0.49, p = 0.621; Std. beta =
## -6.01e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.71, 95% CI [-17.26, 5.84], t(2038) = -0.97, p = 0.332; Std. beta = -0.38,
## 95% CI [-1.16, 0.41])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.02, 95% CI [-32.58, -1.45], t(2038) = -2.14, p = 0.032; Std. beta = -1.97,
## 95% CI [-4.39, 0.46])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-25.34, 27.40], t(2038) = 0.08, p = 0.939; Std. beta = -0.04,
## 95% CI [-1.65, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-11.39, 12.41], t(2038) = 0.08, p = 0.933; Std. beta = 0.35,
## 95% CI [-0.41, 1.10])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-8.18, 19.73], t(2038) = 0.81, p = 0.417; Std. beta = 0.52, 95%
## CI [-0.44, 1.49])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -8.10, 95% CI [-21.46, 5.27], t(2038) = -1.19, p = 0.235; Std. beta = -0.70,
## 95% CI [-1.68, 0.28])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.33, 95% CI [-14.61, 5.95], t(2038) = -0.83, p = 0.409; Std. beta = -0.04,
## 95% CI [-0.74, 0.65])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.95, 3.09], t(2038) = -1.58, p = 0.114; Std. beta = 0.19,
## 95% CI [-0.93, 1.30])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.82, 15.69], t(2038) = 0.66, p = 0.512; Std. beta = 0.78, 95%
## CI [-0.04, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.67, 15.12], t(2038) = 0.34, p = 0.736; Std. beta = 0.09,
## 95% CI [-0.75, 0.93])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.17, 95% CI [-10.45, 8.11], t(2038) = -0.25, p = 0.805; Std. beta = -0.09,
## 95% CI [-0.71, 0.52])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.10, 95% CI [-19.29, 33.48], t(2038) = 0.53, p = 0.598; Std. beta = -2.25,
## 95% CI [-4.34, -0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-16.50, 20.39], t(2038) = 0.21, p = 0.836; Std. beta = 0.51,
## 95% CI [-0.80, 1.81])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.97, 95% CI [-28.54, 2.61], t(2038) = -1.63, p = 0.103; Std. beta = -0.34,
## 95% CI [-1.67, 0.99])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.33, 95% CI [-17.11, 0.46], t(2038) = -1.86, p = 0.063; Std. beta = -0.72,
## 95% CI [-1.76, 0.32])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically significant and
## positive (beta = 1.92, 95% CI [0.10, 3.75], t(2038) = 2.06, p = 0.039; Std.
## beta = 0.14, 95% CI [6.76e-03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.97, 95% CI [-68.37, 4.43], t(2038) = -1.72, p = 0.085;
## Std. beta = -3.44, 95% CI [-7.35, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.10, 95% CI [-10.71, 12.90], t(2038) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.15, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-12.83, 11.69], t(2038) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.06, 11.49], t(2038) = -0.44, p = 0.663;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-4.89, 15.07], t(2038) = 1.00, p = 0.318; Std.
## beta = 0.55, 95% CI [-0.53, 1.62])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-4.20, 2.02], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.12, 95% CI [-0.45, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.76, 95% CI [-5.59, 11.11], t(2038) = 0.65, p = 0.517; Std.
## beta = 0.30, 95% CI [-0.60, 1.19])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-1.82, 3.79], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.11, 95% CI [-0.20, 0.41])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.96, 5.62], t(2038) = 0.34, p = 0.733; Std.
## beta = 0.09, 95% CI [-0.43, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.03, 95% CI [0.79, 7.28], t(2038) = 2.44, p = 0.015; Std.
## beta = 0.43, 95% CI [0.08, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-2.43, 13.12], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.57, 95% CI [-0.26, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.03, 4.67], t(2038) = 1.25, p = 0.210; Std.
## beta = 0.20, 95% CI [-0.11, 0.50])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-0.44, 6.72], t(2038) = 1.72, p = 0.085; Std.
## beta = 0.34, 95% CI [-0.05, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.24, 95% CI [-27.33, 4.86], t(2038) = -1.37, p = 0.171;
## Std. beta = -1.21, 95% CI [-2.94, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-0.50, 13.78], t(2038) = 1.82, p = 0.068; Std.
## beta = 0.71, 95% CI [-0.05, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.35, 95% CI [1.47, 13.22], t(2038) = 2.45, p = 0.014; Std.
## beta = 0.79, 95% CI [0.16, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.61, 9.98], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.24, 95% CI [-0.60, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.54, 9.21], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.14, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-56.02, 36.87], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.03, 95% CI [-6.02, 3.96])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-28.45, 27.03], t(2038) = -0.05, p = 0.960;
## Std. beta = -0.08, 95% CI [-3.06, 2.91])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.13, 95% CI [-5.10, 5.37], t(2038) = 0.05, p = 0.960; Std.
## beta = 0.01, 95% CI [-0.55, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.54, 95% CI [-34.06, 16.98], t(2038) = -0.66, p = 0.512;
## Std. beta = -0.92, 95% CI [-3.66, 1.83])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.60, 95% CI [-3.32, 10.51], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.39, 95% CI [-0.36, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.13, 9.53], t(2038) = 0.77, p = 0.439; Std.
## beta = 0.29, 95% CI [-0.44, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.40, 95% CI [-2.01, 16.81], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.80, 95% CI [-0.22, 1.81])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.53, 95% CI [0.01, 11.05], t(2038) = 1.97, p = 0.050; Std.
## beta = 0.59, 95% CI [1.19e-03, 1.19])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-9.48, 11.91], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.02, 1.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-6.92, 3.21], t(2038) = -0.72, p = 0.472; Std.
## beta = -0.20, 95% CI [-0.74, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-6.08, 6.29], t(2038) = 0.03, p = 0.973; Std.
## beta = 0.01, 95% CI [-0.65, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.40, 95% CI [-34.03, 17.22], t(2038) = -0.64, p = 0.520;
## Std. beta = -0.90, 95% CI [-3.66, 1.85])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-11.18, 8.87], t(2038) = -0.23, p = 0.821; Std.
## beta = -0.12, 95% CI [-1.20, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-1.02, 7.50], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.35, 95% CI [-0.11, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-6.00, 8.71], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.15, 95% CI [-0.65, 0.94])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-9.04, 5.89], t(2038) = -0.41, p = 0.679; Std.
## beta = -0.17, 95% CI [-0.97, 0.63])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-2.29, 7.49], t(2038) = 1.04, p = 0.298; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.94, 95% CI [1.62, 20.26], t(2038) = 2.30, p = 0.021; Std.
## beta = 1.18, 95% CI [0.17, 2.18])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.29, 95% CI [-0.44, 11.02], t(2038) = 1.81, p = 0.070; Std.
## beta = 0.57, 95% CI [-0.05, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-6.21, 5.00], t(2038) = -0.21, p = 0.833; Std.
## beta = -0.06, 95% CI [-0.67, 0.54])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-4.28, 4.00], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.02, 95% CI [-0.46, 0.43])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.11, 95% CI [-48.61, -7.60], t(2038) = -2.69, p = 0.007;
## Std. beta = -3.02, 95% CI [-5.23, -0.82])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-5.18, 12.90], t(2038) = 0.84, p = 0.403; Std.
## beta = 0.41, 95% CI [-0.56, 1.39])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.56, 95% CI [-7.60, 18.71], t(2038) = 0.83, p = 0.407; Std.
## beta = 0.60, 95% CI [-0.82, 2.01])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-13.35, 10.01], t(2038) = -0.28, p = 0.779;
## Std. beta = -0.18, 95% CI [-1.44, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.32. The model's intercept, corresponding to site =
## Simmons, is at 40.21 (95% CI [34.17, 46.25], t(2038) = 13.06, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.63, 95% CI [-10.84, -4.41], t(2038) = -4.65, p < .001; Std. beta = -0.61,
## 95% CI [-0.78, -0.45])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.17, 95% CI [-3.44, 3.79], t(2038) = 0.09, p = 0.924; Std. beta =
## 0.13, 95% CI [-0.04, 0.30])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.75, 95% CI [-28.88, 25.38], t(2038) = -0.13, p = 0.899; Std. beta = -3.22,
## 95% CI [-6.45, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.64, 95% CI [5.80, 45.47], t(2038) = 2.53, p = 0.011; Std. beta = 1.84, 95%
## CI [0.57, 3.11])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-23.60, 13.07], t(2038) = -0.56, p = 0.573; Std. beta = -0.41,
## 95% CI [-1.81, 0.99])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.78, 2.76], t(2038) = -1.61, p = 0.108; Std. beta = -1.16,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.01, 95% CI [-14.30, 24.33], t(2038) = 0.51, p = 0.611; Std. beta = 0.83,
## 95% CI [-0.52, 2.19])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.67, 95% CI [-2.01, 13.35], t(2038) = 1.45, p = 0.148; Std. beta = 0.28, 95%
## CI [-0.22, 0.78])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -8.20, 95% CI [-26.97, 10.57], t(2038) = -0.86, p = 0.392; Std. beta = -0.29,
## 95% CI [-1.55, 0.98])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.47, 95% CI [14.33, 26.61], t(2038) = 6.54, p < .001; Std. beta = 1.48, 95%
## CI [1.06, 1.90])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-1.37, 20.06], t(2038) = 1.71, p = 0.087; Std. beta = 0.71, 95%
## CI [3.67e-03, 1.42])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.43, 95% CI [-8.02, 5.16], t(2038) = -0.43, p = 0.670; Std. beta = 0.29,
## 95% CI [-0.16, 0.75])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-20.48, 2.41], t(2038) = -1.55, p = 0.122; Std. beta = -0.09,
## 95% CI [-1.00, 0.82])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-4.15, 8.25], t(2038) = 0.65, p = 0.517; Std. beta = 0.32, 95%
## CI [-0.11, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.40, 95% CI [-10.72, 3.92], t(2038) = -0.91, p = 0.362; Std. beta = 0.07,
## 95% CI [-0.41, 0.56])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-8.36, 30.08], t(2038) = 1.11, p = 0.268; Std. beta = -0.36,
## 95% CI [-1.94, 1.23])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-22.86, 8.39], t(2038) = -0.91, p = 0.364; Std. beta = 0.15,
## 95% CI [-0.86, 1.17])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.30, 95% CI [-22.52, 31.11], t(2038) = 0.31, p = 0.753; Std. beta = 0.29,
## 95% CI [-1.52, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.15, 95% CI [-10.12, 16.43], t(2038) = 0.47, p = 0.641; Std. beta = 0.93,
## 95% CI [0.03, 1.82])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.59, 95% CI [-27.13, 9.94], t(2038) = -0.91, p = 0.363; Std. beta = -0.37,
## 95% CI [-1.62, 0.89])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-24.45, 4.95], t(2038) = -1.30, p = 0.194; Std. beta = -0.53,
## 95% CI [-1.49, 0.43])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-35.59, 23.57], t(2038) = -0.40, p = 0.690; Std. beta = -1.33,
## 95% CI [-4.51, 1.84])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.19, 95% CI [-50.10, 3.73], t(2038) = -1.69, p = 0.091; Std. beta = -1.64,
## 95% CI [-4.14, 0.87])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-19.80, 3.46], t(2038) = -1.38, p = 0.168; Std. beta = -0.54,
## 95% CI [-1.34, 0.26])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.70, 95% CI [32.72, 86.68], t(2038) = 4.34, p < .001; Std. beta = 4.04, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-23.88, 14.98], t(2038) = -0.45, p = 0.653; Std. beta = -1.13,
## 95% CI [-3.54, 1.28])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-17.41, 6.69], t(2038) = -0.87, p = 0.383; Std. beta = -0.01,
## 95% CI [-0.88, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.53, 95% CI [-13.77, 8.71], t(2038) = -0.44, p = 0.659; Std. beta = 0.09,
## 95% CI [-0.72, 0.90])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.40, 95% CI [-37.66, 12.85], t(2038) = -0.96, p = 0.336; Std. beta =
## -0.12, 95% CI [-1.71, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.77, 95% CI [-19.43, -2.11], t(2038) = -2.44, p = 0.015; Std. beta = -0.19,
## 95% CI [-0.83, 0.44])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.50, 95% CI [-31.02, -5.98], t(2038) = -2.90, p = 0.004; Std. beta = -1.13,
## 95% CI [-2.27, 4.15e-03])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-7.64, 12.79], t(2038) = 0.49, p = 0.621; Std. beta =
## -6.01e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.71, 95% CI [-17.26, 5.84], t(2038) = -0.97, p = 0.332; Std. beta = -0.38,
## 95% CI [-1.16, 0.41])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.02, 95% CI [-32.58, -1.45], t(2038) = -2.14, p = 0.032; Std. beta = -1.97,
## 95% CI [-4.39, 0.46])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-25.34, 27.40], t(2038) = 0.08, p = 0.939; Std. beta = -0.04,
## 95% CI [-1.65, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-11.39, 12.41], t(2038) = 0.08, p = 0.933; Std. beta = 0.35,
## 95% CI [-0.41, 1.10])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-8.18, 19.73], t(2038) = 0.81, p = 0.417; Std. beta = 0.52, 95%
## CI [-0.44, 1.49])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -8.10, 95% CI [-21.46, 5.27], t(2038) = -1.19, p = 0.235; Std. beta = -0.70,
## 95% CI [-1.68, 0.28])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.33, 95% CI [-14.61, 5.95], t(2038) = -0.83, p = 0.409; Std. beta = -0.04,
## 95% CI [-0.74, 0.65])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.95, 3.09], t(2038) = -1.58, p = 0.114; Std. beta = 0.19,
## 95% CI [-0.93, 1.30])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.82, 15.69], t(2038) = 0.66, p = 0.512; Std. beta = 0.78, 95%
## CI [-0.04, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.67, 15.12], t(2038) = 0.34, p = 0.736; Std. beta = 0.09,
## 95% CI [-0.75, 0.93])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.17, 95% CI [-10.45, 8.11], t(2038) = -0.25, p = 0.805; Std. beta = -0.09,
## 95% CI [-0.71, 0.52])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.10, 95% CI [-19.29, 33.48], t(2038) = 0.53, p = 0.598; Std. beta = -2.25,
## 95% CI [-4.34, -0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-16.50, 20.39], t(2038) = 0.21, p = 0.836; Std. beta = 0.51,
## 95% CI [-0.80, 1.81])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.97, 95% CI [-28.54, 2.61], t(2038) = -1.63, p = 0.103; Std. beta = -0.34,
## 95% CI [-1.67, 0.99])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.33, 95% CI [-17.11, 0.46], t(2038) = -1.86, p = 0.063; Std. beta = -0.72,
## 95% CI [-1.76, 0.32])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically significant and
## positive (beta = 1.92, 95% CI [0.10, 3.75], t(2038) = 2.06, p = 0.039; Std.
## beta = 0.14, 95% CI [6.76e-03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.97, 95% CI [-68.37, 4.43], t(2038) = -1.72, p = 0.085;
## Std. beta = -3.44, 95% CI [-7.35, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.10, 95% CI [-10.71, 12.90], t(2038) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.15, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-12.83, 11.69], t(2038) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.06, 11.49], t(2038) = -0.44, p = 0.663;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-4.89, 15.07], t(2038) = 1.00, p = 0.318; Std.
## beta = 0.55, 95% CI [-0.53, 1.62])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-4.20, 2.02], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.12, 95% CI [-0.45, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.76, 95% CI [-5.59, 11.11], t(2038) = 0.65, p = 0.517; Std.
## beta = 0.30, 95% CI [-0.60, 1.19])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-1.82, 3.79], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.11, 95% CI [-0.20, 0.41])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.96, 5.62], t(2038) = 0.34, p = 0.733; Std.
## beta = 0.09, 95% CI [-0.43, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.03, 95% CI [0.79, 7.28], t(2038) = 2.44, p = 0.015; Std.
## beta = 0.43, 95% CI [0.08, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-2.43, 13.12], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.57, 95% CI [-0.26, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.03, 4.67], t(2038) = 1.25, p = 0.210; Std.
## beta = 0.20, 95% CI [-0.11, 0.50])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-0.44, 6.72], t(2038) = 1.72, p = 0.085; Std.
## beta = 0.34, 95% CI [-0.05, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.24, 95% CI [-27.33, 4.86], t(2038) = -1.37, p = 0.171;
## Std. beta = -1.21, 95% CI [-2.94, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-0.50, 13.78], t(2038) = 1.82, p = 0.068; Std.
## beta = 0.71, 95% CI [-0.05, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.35, 95% CI [1.47, 13.22], t(2038) = 2.45, p = 0.014; Std.
## beta = 0.79, 95% CI [0.16, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.61, 9.98], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.24, 95% CI [-0.60, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.54, 9.21], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.14, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-56.02, 36.87], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.03, 95% CI [-6.02, 3.96])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-28.45, 27.03], t(2038) = -0.05, p = 0.960;
## Std. beta = -0.08, 95% CI [-3.06, 2.91])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.13, 95% CI [-5.10, 5.37], t(2038) = 0.05, p = 0.960; Std.
## beta = 0.01, 95% CI [-0.55, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.54, 95% CI [-34.06, 16.98], t(2038) = -0.66, p = 0.512;
## Std. beta = -0.92, 95% CI [-3.66, 1.83])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.60, 95% CI [-3.32, 10.51], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.39, 95% CI [-0.36, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.13, 9.53], t(2038) = 0.77, p = 0.439; Std.
## beta = 0.29, 95% CI [-0.44, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.40, 95% CI [-2.01, 16.81], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.80, 95% CI [-0.22, 1.81])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.53, 95% CI [0.01, 11.05], t(2038) = 1.97, p = 0.050; Std.
## beta = 0.59, 95% CI [1.19e-03, 1.19])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-9.48, 11.91], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.02, 1.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-6.92, 3.21], t(2038) = -0.72, p = 0.472; Std.
## beta = -0.20, 95% CI [-0.74, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-6.08, 6.29], t(2038) = 0.03, p = 0.973; Std.
## beta = 0.01, 95% CI [-0.65, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.40, 95% CI [-34.03, 17.22], t(2038) = -0.64, p = 0.520;
## Std. beta = -0.90, 95% CI [-3.66, 1.85])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-11.18, 8.87], t(2038) = -0.23, p = 0.821; Std.
## beta = -0.12, 95% CI [-1.20, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-1.02, 7.50], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.35, 95% CI [-0.11, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-6.00, 8.71], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.15, 95% CI [-0.65, 0.94])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-9.04, 5.89], t(2038) = -0.41, p = 0.679; Std.
## beta = -0.17, 95% CI [-0.97, 0.63])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-2.29, 7.49], t(2038) = 1.04, p = 0.298; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.94, 95% CI [1.62, 20.26], t(2038) = 2.30, p = 0.021; Std.
## beta = 1.18, 95% CI [0.17, 2.18])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.29, 95% CI [-0.44, 11.02], t(2038) = 1.81, p = 0.070; Std.
## beta = 0.57, 95% CI [-0.05, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-6.21, 5.00], t(2038) = -0.21, p = 0.833; Std.
## beta = -0.06, 95% CI [-0.67, 0.54])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-4.28, 4.00], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.02, 95% CI [-0.46, 0.43])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.11, 95% CI [-48.61, -7.60], t(2038) = -2.69, p = 0.007;
## Std. beta = -3.02, 95% CI [-5.23, -0.82])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-5.18, 12.90], t(2038) = 0.84, p = 0.403; Std.
## beta = 0.41, 95% CI [-0.56, 1.39])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.56, 95% CI [-7.60, 18.71], t(2038) = 0.83, p = 0.407; Std.
## beta = 0.60, 95% CI [-0.82, 2.01])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-13.35, 10.01], t(2038) = -0.28, p = 0.779;
## Std. beta = -0.18, 95% CI [-1.44, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to cohort = CARE-PF, is at 40.21 (95% CI [34.17, 46.25], t(2038)
## = 13.06, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.63, 95% CI [-10.84, -4.41], t(2038) = -4.65, p < .001; Std. beta = -0.61,
## 95% CI [-0.78, -0.45])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.17, 95% CI [-3.44, 3.79], t(2038) = 0.09, p = 0.924; Std. beta =
## 0.13, 95% CI [-0.04, 0.30])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.75, 95% CI [-28.88, 25.38], t(2038) = -0.13, p = 0.899; Std. beta = -3.22,
## 95% CI [-6.45, 0.02])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.64, 95% CI [5.80, 45.47], t(2038) = 2.53, p = 0.011; Std. beta = 1.84, 95%
## CI [0.57, 3.11])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-23.60, 13.07], t(2038) = -0.56, p = 0.573; Std. beta = -0.41,
## 95% CI [-1.81, 0.99])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.51, 95% CI [-27.78, 2.76], t(2038) = -1.61, p = 0.108; Std. beta = -1.16,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.01, 95% CI [-14.30, 24.33], t(2038) = 0.51, p = 0.611; Std. beta = 0.83,
## 95% CI [-0.52, 2.19])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.67, 95% CI [-2.01, 13.35], t(2038) = 1.45, p = 0.148; Std. beta = 0.28, 95%
## CI [-0.22, 0.78])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -8.20, 95% CI [-26.97, 10.57], t(2038) = -0.86, p = 0.392; Std. beta = -0.29,
## 95% CI [-1.55, 0.98])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.47, 95% CI [14.33, 26.61], t(2038) = 6.54, p < .001; Std. beta = 1.48, 95%
## CI [1.06, 1.90])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.35, 95% CI [-1.37, 20.06], t(2038) = 1.71, p = 0.087; Std. beta = 0.71, 95%
## CI [3.67e-03, 1.42])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.43, 95% CI [-8.02, 5.16], t(2038) = -0.43, p = 0.670; Std. beta = 0.29,
## 95% CI [-0.16, 0.75])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-20.48, 2.41], t(2038) = -1.55, p = 0.122; Std. beta = -0.09,
## 95% CI [-1.00, 0.82])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-4.15, 8.25], t(2038) = 0.65, p = 0.517; Std. beta = 0.32, 95%
## CI [-0.11, 0.74])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.40, 95% CI [-10.72, 3.92], t(2038) = -0.91, p = 0.362; Std. beta = 0.07,
## 95% CI [-0.41, 0.56])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.86, 95% CI [-8.36, 30.08], t(2038) = 1.11, p = 0.268; Std. beta = -0.36,
## 95% CI [-1.94, 1.23])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-22.86, 8.39], t(2038) = -0.91, p = 0.364; Std. beta = 0.15,
## 95% CI [-0.86, 1.17])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 4.30, 95% CI [-22.52, 31.11], t(2038) = 0.31, p = 0.753; Std. beta = 0.29,
## 95% CI [-1.52, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.15, 95% CI [-10.12, 16.43], t(2038) = 0.47, p = 0.641; Std. beta = 0.93,
## 95% CI [0.03, 1.82])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.59, 95% CI [-27.13, 9.94], t(2038) = -0.91, p = 0.363; Std. beta = -0.37,
## 95% CI [-1.62, 0.89])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.75, 95% CI [-24.45, 4.95], t(2038) = -1.30, p = 0.194; Std. beta = -0.53,
## 95% CI [-1.49, 0.43])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -6.01, 95% CI [-35.59, 23.57], t(2038) = -0.40, p = 0.690; Std. beta = -1.33,
## 95% CI [-4.51, 1.84])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.19, 95% CI [-50.10, 3.73], t(2038) = -1.69, p = 0.091; Std. beta = -1.64,
## 95% CI [-4.14, 0.87])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.17, 95% CI [-19.80, 3.46], t(2038) = -1.38, p = 0.168; Std. beta = -0.54,
## 95% CI [-1.34, 0.26])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.70, 95% CI [32.72, 86.68], t(2038) = 4.34, p < .001; Std. beta = 4.04, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-23.88, 14.98], t(2038) = -0.45, p = 0.653; Std. beta = -1.13,
## 95% CI [-3.54, 1.28])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.36, 95% CI [-17.41, 6.69], t(2038) = -0.87, p = 0.383; Std. beta = -0.01,
## 95% CI [-0.88, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.53, 95% CI [-13.77, 8.71], t(2038) = -0.44, p = 0.659; Std. beta = 0.09,
## 95% CI [-0.72, 0.90])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.40, 95% CI [-37.66, 12.85], t(2038) = -0.96, p = 0.336; Std. beta =
## -0.12, 95% CI [-1.71, 1.47])
## - The effect of site [22R] is statistically significant and negative (beta =
## -10.77, 95% CI [-19.43, -2.11], t(2038) = -2.44, p = 0.015; Std. beta = -0.19,
## 95% CI [-0.83, 0.44])
## - The effect of site [23R] is statistically significant and negative (beta =
## -18.50, 95% CI [-31.02, -5.98], t(2038) = -2.90, p = 0.004; Std. beta = -1.13,
## 95% CI [-2.27, 4.15e-03])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.57, 95% CI [-7.64, 12.79], t(2038) = 0.49, p = 0.621; Std. beta =
## -6.01e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.71, 95% CI [-17.26, 5.84], t(2038) = -0.97, p = 0.332; Std. beta = -0.38,
## 95% CI [-1.16, 0.41])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.02, 95% CI [-32.58, -1.45], t(2038) = -2.14, p = 0.032; Std. beta = -1.97,
## 95% CI [-4.39, 0.46])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 1.03, 95% CI [-25.34, 27.40], t(2038) = 0.08, p = 0.939; Std. beta = -0.04,
## 95% CI [-1.65, 1.57])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.51, 95% CI [-11.39, 12.41], t(2038) = 0.08, p = 0.933; Std. beta = 0.35,
## 95% CI [-0.41, 1.10])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.77, 95% CI [-8.18, 19.73], t(2038) = 0.81, p = 0.417; Std. beta = 0.52, 95%
## CI [-0.44, 1.49])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -8.10, 95% CI [-21.46, 5.27], t(2038) = -1.19, p = 0.235; Std. beta = -0.70,
## 95% CI [-1.68, 0.28])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.33, 95% CI [-14.61, 5.95], t(2038) = -0.83, p = 0.409; Std. beta = -0.04,
## 95% CI [-0.74, 0.65])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.95, 3.09], t(2038) = -1.58, p = 0.114; Std. beta = 0.19,
## 95% CI [-0.93, 1.30])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.82, 15.69], t(2038) = 0.66, p = 0.512; Std. beta = 0.78, 95%
## CI [-0.04, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.22, 95% CI [-10.67, 15.12], t(2038) = 0.34, p = 0.736; Std. beta = 0.09,
## 95% CI [-0.75, 0.93])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.17, 95% CI [-10.45, 8.11], t(2038) = -0.25, p = 0.805; Std. beta = -0.09,
## 95% CI [-0.71, 0.52])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.10, 95% CI [-19.29, 33.48], t(2038) = 0.53, p = 0.598; Std. beta = -2.25,
## 95% CI [-4.34, -0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-16.50, 20.39], t(2038) = 0.21, p = 0.836; Std. beta = 0.51,
## 95% CI [-0.80, 1.81])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.97, 95% CI [-28.54, 2.61], t(2038) = -1.63, p = 0.103; Std. beta = -0.34,
## 95% CI [-1.67, 0.99])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.33, 95% CI [-17.11, 0.46], t(2038) = -1.86, p = 0.063; Std. beta = -0.72,
## 95% CI [-1.76, 0.32])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically significant and
## positive (beta = 1.92, 95% CI [0.10, 3.75], t(2038) = 2.06, p = 0.039; Std.
## beta = 0.14, 95% CI [6.76e-03, 0.26])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -31.97, 95% CI [-68.37, 4.43], t(2038) = -1.72, p = 0.085;
## Std. beta = -3.44, 95% CI [-7.35, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.10, 95% CI [-10.71, 12.90], t(2038) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.15, 1.39])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -0.57, 95% CI [-12.83, 11.69], t(2038) = -0.09, p = 0.927;
## Std. beta = -0.06, 95% CI [-1.38, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.06, 11.49], t(2038) = -0.44, p = 0.663;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-4.89, 15.07], t(2038) = 1.00, p = 0.318; Std.
## beta = 0.55, 95% CI [-0.53, 1.62])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.09, 95% CI [-4.20, 2.02], t(2038) = -0.69, p = 0.491; Std.
## beta = -0.12, 95% CI [-0.45, 0.22])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.76, 95% CI [-5.59, 11.11], t(2038) = 0.65, p = 0.517; Std.
## beta = 0.30, 95% CI [-0.60, 1.19])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.99, 95% CI [-1.82, 3.79], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.11, 95% CI [-0.20, 0.41])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-3.96, 5.62], t(2038) = 0.34, p = 0.733; Std.
## beta = 0.09, 95% CI [-0.43, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.03, 95% CI [0.79, 7.28], t(2038) = 2.44, p = 0.015; Std.
## beta = 0.43, 95% CI [0.08, 0.78])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-2.43, 13.12], t(2038) = 1.35, p = 0.178; Std.
## beta = 0.57, 95% CI [-0.26, 1.41])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.03, 4.67], t(2038) = 1.25, p = 0.210; Std.
## beta = 0.20, 95% CI [-0.11, 0.50])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.14, 95% CI [-0.44, 6.72], t(2038) = 1.72, p = 0.085; Std.
## beta = 0.34, 95% CI [-0.05, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.24, 95% CI [-27.33, 4.86], t(2038) = -1.37, p = 0.171;
## Std. beta = -1.21, 95% CI [-2.94, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.64, 95% CI [-0.50, 13.78], t(2038) = 1.82, p = 0.068; Std.
## beta = 0.71, 95% CI [-0.05, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.35, 95% CI [1.47, 13.22], t(2038) = 2.45, p = 0.014; Std.
## beta = 0.79, 95% CI [0.16, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.61, 9.98], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.24, 95% CI [-0.60, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.54, 9.21], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.14, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-56.02, 36.87], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.03, 95% CI [-6.02, 3.96])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-28.45, 27.03], t(2038) = -0.05, p = 0.960;
## Std. beta = -0.08, 95% CI [-3.06, 2.91])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## positive (beta = 0.13, 95% CI [-5.10, 5.37], t(2038) = 0.05, p = 0.960; Std.
## beta = 0.01, 95% CI [-0.55, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.54, 95% CI [-34.06, 16.98], t(2038) = -0.66, p = 0.512;
## Std. beta = -0.92, 95% CI [-3.66, 1.83])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.60, 95% CI [-3.32, 10.51], t(2038) = 1.02, p = 0.308; Std.
## beta = 0.39, 95% CI [-0.36, 1.13])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.70, 95% CI [-4.13, 9.53], t(2038) = 0.77, p = 0.439; Std.
## beta = 0.29, 95% CI [-0.44, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.40, 95% CI [-2.01, 16.81], t(2038) = 1.54, p = 0.123; Std.
## beta = 0.80, 95% CI [-0.22, 1.81])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.53, 95% CI [0.01, 11.05], t(2038) = 1.97, p = 0.050; Std.
## beta = 0.59, 95% CI [1.19e-03, 1.19])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-9.48, 11.91], t(2038) = 0.22, p = 0.824; Std.
## beta = 0.13, 95% CI [-1.02, 1.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-6.92, 3.21], t(2038) = -0.72, p = 0.472; Std.
## beta = -0.20, 95% CI [-0.74, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.10, 95% CI [-6.08, 6.29], t(2038) = 0.03, p = 0.973; Std.
## beta = 0.01, 95% CI [-0.65, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.40, 95% CI [-34.03, 17.22], t(2038) = -0.64, p = 0.520;
## Std. beta = -0.90, 95% CI [-3.66, 1.85])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-11.18, 8.87], t(2038) = -0.23, p = 0.821; Std.
## beta = -0.12, 95% CI [-1.20, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-1.02, 7.50], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.35, 95% CI [-0.11, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.35, 95% CI [-6.00, 8.71], t(2038) = 0.36, p = 0.718; Std.
## beta = 0.15, 95% CI [-0.65, 0.94])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-9.04, 5.89], t(2038) = -0.41, p = 0.679; Std.
## beta = -0.17, 95% CI [-0.97, 0.63])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-2.29, 7.49], t(2038) = 1.04, p = 0.298; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.94, 95% CI [1.62, 20.26], t(2038) = 2.30, p = 0.021; Std.
## beta = 1.18, 95% CI [0.17, 2.18])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.29, 95% CI [-0.44, 11.02], t(2038) = 1.81, p = 0.070; Std.
## beta = 0.57, 95% CI [-0.05, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-6.21, 5.00], t(2038) = -0.21, p = 0.833; Std.
## beta = -0.06, 95% CI [-0.67, 0.54])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.14, 95% CI [-4.28, 4.00], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.02, 95% CI [-0.46, 0.43])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.11, 95% CI [-48.61, -7.60], t(2038) = -2.69, p = 0.007;
## Std. beta = -3.02, 95% CI [-5.23, -0.82])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-5.18, 12.90], t(2038) = 0.84, p = 0.403; Std.
## beta = 0.41, 95% CI [-0.56, 1.39])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.56, 95% CI [-7.60, 18.71], t(2038) = 0.83, p = 0.407; Std.
## beta = 0.60, 95% CI [-0.82, 2.01])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-13.35, 10.01], t(2038) = -0.28, p = 0.779;
## Std. beta = -0.18, 95% CI [-1.44, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*NH4_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14678.7
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1266 -0.4910 -0.0117 0.4374 7.1073
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 139.21 11.799
## time_firstPFT 10.65 3.263 -0.28
## Residual 41.81 6.466
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 36.165255 6.233755 5.802
## time_firstPFT -6.383022 2.988691 -2.136
## NH4_5yrPreDx 0.961416 1.934933 0.497
## disadv -5.347166 2.369080 -2.257
## dich_RaceNon-White -3.316982 2.307136 -1.438
## sexF -2.567051 1.431395 -1.793
## age_dx 0.140587 0.075273 1.868
## smokeHxFormer -2.754468 1.413936 -1.948
## smokeHxAlways 9.621091 7.063347 1.362
## smokeHxUnknown -3.139418 3.199751 -0.981
## site02R -4.612448 13.734612 -0.336
## site03R 22.136680 10.123796 2.187
## site04R -4.448674 9.241337 -0.481
## site05R -12.815435 7.726405 -1.659
## site06R -7.117417 13.621594 -0.523
## site07R 4.272547 3.902794 1.095
## site09R -9.965225 9.503830 -1.049
## site101 21.309842 3.200166 6.659
## site102 9.061183 5.560547 1.630
## site103 -0.233838 3.561602 -0.066
## site104 -6.853035 5.868629 -1.168
## site105 3.319236 3.236091 1.026
## site106 -4.764703 3.803356 -1.253
## site107 9.068185 9.744731 0.931
## site108 -0.675381 8.328767 -0.081
## site10R 5.034183 13.626880 0.369
## site11R 2.744082 6.694550 0.410
## site12R -6.797372 9.338300 -0.728
## site13R -10.777548 7.486070 -1.440
## site14R -7.459287 15.046364 -0.496
## site15R -19.313206 13.605150 -1.420
## site16R -7.533719 5.976318 -1.261
## site17R 64.651007 13.778195 4.692
## site18R -2.245517 9.798913 -0.229
## site19R -4.979420 6.131055 -0.812
## site20R -2.365574 5.710243 -0.414
## site21R -11.521284 12.690931 -0.908
## site22R -13.001213 4.436769 -2.930
## site23R -24.099820 7.927486 -3.040
## site24R 2.437846 5.165155 0.472
## site25R -7.524137 5.913003 -1.272
## site28R -15.366975 7.899334 -1.945
## site29R -2.048336 13.334426 -0.154
## site31R 0.571821 6.149384 0.093
## site32R 6.945384 7.089988 0.980
## site33R -7.971638 6.775126 -1.177
## site34R -3.791339 5.199891 -0.729
## site35R -12.818423 8.101528 -1.582
## site36R 3.661543 5.948046 0.616
## site37R 0.824208 6.595689 0.125
## site38R 0.007661 4.718665 0.002
## site39R 16.047083 13.600717 1.180
## site40R 0.823069 9.289482 0.089
## site41R -12.994605 7.932339 -1.638
## site42R -9.869325 4.487545 -2.199
## time_firstPFT:NH4_5yrPreDx 1.645196 1.013172 1.624
## time_firstPFT:disadv 1.654067 1.102601 1.500
## time_firstPFT:dich_RaceNon-White -0.743197 1.103820 -0.673
## time_firstPFT:sexF 0.480797 0.658767 0.730
## time_firstPFT:age_dx -0.025346 0.034521 -0.734
## time_firstPFT:smokeHxFormer -0.621826 0.664240 -0.936
## time_firstPFT:smokeHxAlways -6.280135 6.021255 -1.043
## time_firstPFT:smokeHxUnknown 1.811293 1.661522 1.090
## time_firstPFT:site02R -30.867508 18.590362 -1.660
## time_firstPFT:site03R 1.110620 6.081868 0.183
## time_firstPFT:site04R -1.404853 6.293784 -0.223
## time_firstPFT:site05R -3.097638 7.556668 -0.410
## time_firstPFT:site07R -0.847097 1.623467 -0.522
## time_firstPFT:site09R 3.522223 4.292729 0.821
## time_firstPFT:site101 0.832446 1.471879 0.566
## time_firstPFT:site102 1.185525 2.520720 0.470
## time_firstPFT:site103 4.008726 1.799953 2.227
## time_firstPFT:site104 4.369641 4.047033 1.080
## time_firstPFT:site105 1.640976 1.506629 1.089
## time_firstPFT:site106 3.374200 1.885595 1.789
## time_firstPFT:site107 -10.698139 8.235685 -1.299
## time_firstPFT:site108 6.956632 3.882152 1.792
## time_firstPFT:site11R 7.496806 3.042983 2.464
## time_firstPFT:site12R 2.358340 3.995960 0.590
## time_firstPFT:site13R 1.174997 4.071682 0.289
## time_firstPFT:site14R -8.815906 23.705639 -0.372
## time_firstPFT:site15R -1.197313 14.169100 -0.085
## time_firstPFT:site16R -0.009744 2.756595 -0.004
## time_firstPFT:site18R -8.941729 13.023351 -0.687
## time_firstPFT:site19R 3.148834 3.556667 0.885
## time_firstPFT:site20R 2.326739 3.552008 0.655
## time_firstPFT:site21R 7.540550 4.809777 1.568
## time_firstPFT:site22R 6.462304 2.860842 2.259
## time_firstPFT:site23R 24.454928 26.816987 0.912
## time_firstPFT:site24R -1.756904 2.606227 -0.674
## time_firstPFT:site25R 0.651593 3.229614 0.202
## time_firstPFT:site28R -7.294667 13.146960 -0.555
## time_firstPFT:site29R 0.066481 5.161944 0.013
## time_firstPFT:site31R 3.821019 2.283546 1.673
## time_firstPFT:site32R 1.361283 3.799507 0.358
## time_firstPFT:site33R -2.470167 3.866136 -0.639
## time_firstPFT:site34R 2.356202 2.523306 0.934
## time_firstPFT:site35R 11.075081 4.778819 2.318
## time_firstPFT:site36R 5.248614 2.948075 1.780
## time_firstPFT:site37R -0.312290 2.978293 -0.105
## time_firstPFT:site38R -0.361779 2.143817 -0.169
## time_firstPFT:site39R -28.212751 10.564072 -2.671
## time_firstPFT:site40R 3.037281 4.664609 0.651
## time_firstPFT:site41R 5.905911 6.731591 0.877
## time_firstPFT:site42R -2.360990 5.971966 -0.395##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.789
## Unadjusted ICC: 0.527report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NH4_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to time_firstPFT = 0, is at 36.17 (95% CI [23.94, 48.39], t(2008)
## = 5.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NH4_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to NH4_5yrPreDx
## = 0, is at 36.17 (95% CI [23.94, 48.39], t(2008) = 5.80, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to disadv = 0, is at 36.17 (95% CI [23.94,
## 48.39], t(2008) = 5.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to dich_Race = White, is at 36.17 (95% CI
## [23.94, 48.39], t(2008) = 5.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to sex = M, is at 36.17 (95% CI [23.94,
## 48.39], t(2008) = 5.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to age_dx = 0, is at 36.17 (95% CI [23.94,
## 48.39], t(2008) = 5.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to smokeHx = Never, is at 36.17 (95% CI
## [23.94, 48.39], t(2008) = 5.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to site = Simmons, is at 36.17 (95% CI [23.94,
## 48.39], t(2008) = 5.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to cohort =
## CARE-PF, is at 36.17 (95% CI [23.94, 48.39], t(2008) = 5.80, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.38, 95% CI [-12.24, -0.52], t(2008) = -2.14, p = 0.033; Std. beta = -0.59,
## 95% CI [-0.79, -0.38])
## - The effect of NH4 5yrPreDx is statistically non-significant and positive
## (beta = 0.96, 95% CI [-2.83, 4.76], t(2008) = 0.50, p = 0.619; Std. beta =
## 0.15, 95% CI [-0.03, 0.33])
## - The effect of disadv is statistically significant and negative (beta = -5.35,
## 95% CI [-9.99, -0.70], t(2008) = -2.26, p = 0.024; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-7.84, 1.21], t(2008) = -1.44, p = 0.151; Std.
## beta = -0.30, 95% CI [-0.61, 0.02])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.57, 95% CI [-5.37, 0.24], t(2008) = -1.79, p = 0.073; Std. beta = -0.13, 95%
## CI [-0.32, 0.06])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-7.03e-03, 0.29], t(2008) = 1.87, p = 0.062; Std. beta = 0.06,
## 95% CI [-0.03, 0.16])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.53, 0.02], t(2008) = -1.95, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.43, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.62, 95% CI [-4.23, 23.47], t(2008) = 1.36, p = 0.173; Std. beta =
## 0.04, 95% CI [-1.16, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.14, 95% CI [-9.41, 3.14], t(2008) = -0.98, p = 0.327; Std. beta =
## -0.04, 95% CI [-0.49, 0.42])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-31.55, 22.32], t(2008) = -0.34, p = 0.737; Std. beta = -3.31,
## 95% CI [-6.56, -0.07])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.14, 95% CI [2.28, 41.99], t(2008) = 2.19, p = 0.029; Std. beta = 1.60, 95%
## CI [0.32, 2.88])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-22.57, 13.67], t(2008) = -0.48, p = 0.630; Std. beta = -0.44,
## 95% CI [-1.84, 0.97])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-27.97, 2.34], t(2008) = -1.66, p = 0.097; Std. beta = -1.17,
## 95% CI [-2.59, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.12, 95% CI [-33.83, 19.60], t(2008) = -0.52, p = 0.601; Std. beta = -0.48,
## 95% CI [-2.28, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.27, 95% CI [-3.38, 11.93], t(2008) = 1.09, p = 0.274; Std. beta = 0.21, 95%
## CI [-0.30, 0.71])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.97, 95% CI [-28.60, 8.67], t(2008) = -1.05, p = 0.295; Std. beta = -0.33,
## 95% CI [-1.60, 0.94])
## - The effect of site [101] is statistically significant and positive (beta =
## 21.31, 95% CI [15.03, 27.59], t(2008) = 6.66, p < .001; Std. beta = 1.52, 95%
## CI [1.09, 1.95])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 9.06, 95% CI [-1.84, 19.97], t(2008) = 1.63, p = 0.103; Std. beta = 0.73, 95%
## CI [-2.60e-04, 1.45])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.23, 95% CI [-7.22, 6.75], t(2008) = -0.07, p = 0.948; Std. beta = 0.37,
## 95% CI [-0.12, 0.87])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -6.85, 95% CI [-18.36, 4.66], t(2008) = -1.17, p = 0.243; Std. beta = -0.04,
## 95% CI [-0.96, 0.89])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 3.32, 95% CI [-3.03, 9.67], t(2008) = 1.03, p = 0.305; Std. beta = 0.38, 95%
## CI [-0.05, 0.82])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.76, 95% CI [-12.22, 2.69], t(2008) = -1.25, p = 0.210; Std. beta =
## 6.33e-03, 95% CI [-0.49, 0.51])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.07, 95% CI [-10.04, 28.18], t(2008) = 0.93, p = 0.352; Std. beta = -0.43,
## 95% CI [-2.02, 1.16])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -0.68, 95% CI [-17.01, 15.66], t(2008) = -0.08, p = 0.935; Std. beta = 0.63,
## 95% CI [-0.45, 1.71])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 5.03, 95% CI [-21.69, 31.76], t(2008) = 0.37, p = 0.712; Std. beta = 0.34,
## 95% CI [-1.46, 2.14])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-10.38, 15.87], t(2008) = 0.41, p = 0.682; Std. beta = 0.91,
## 95% CI [0.02, 1.81])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -6.80, 95% CI [-25.11, 11.52], t(2008) = -0.73, p = 0.467; Std. beta = -0.23,
## 95% CI [-1.48, 1.02])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.78, 95% CI [-25.46, 3.90], t(2008) = -1.44, p = 0.150; Std. beta = -0.61,
## 95% CI [-1.58, 0.36])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.46, 95% CI [-36.97, 22.05], t(2008) = -0.50, p = 0.620; Std. beta = -1.36,
## 95% CI [-4.55, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.31, 95% CI [-45.99, 7.37], t(2008) = -1.42, p = 0.156; Std. beta = -1.42,
## 95% CI [-3.93, 1.09])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.25, 4.19], t(2008) = -1.26, p = 0.208; Std. beta = -0.51,
## 95% CI [-1.32, 0.30])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.65, 95% CI [37.63, 91.67], t(2008) = 4.69, p < .001; Std. beta = 4.37, 95%
## CI [2.54, 6.19])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.25, 95% CI [-21.46, 16.97], t(2008) = -0.23, p = 0.819; Std. beta = -1.02,
## 95% CI [-3.43, 1.39])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -4.98, 95% CI [-17.00, 7.04], t(2008) = -0.81, p = 0.417; Std. beta = -0.03,
## 95% CI [-0.90, 0.84])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-13.56, 8.83], t(2008) = -0.41, p = 0.679; Std. beta = 0.07,
## 95% CI [-0.76, 0.89])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-36.41, 13.37], t(2008) = -0.91, p = 0.364; Std. beta =
## -0.04, 95% CI [-1.62, 1.53])
## - The effect of site [22R] is statistically significant and negative (beta =
## -13.00, 95% CI [-21.70, -4.30], t(2008) = -2.93, p = 0.003; Std. beta = -0.25,
## 95% CI [-0.89, 0.39])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.10, 95% CI [-39.65, -8.55], t(2008) = -3.04, p = 0.002; Std. beta = 0.75,
## 95% CI [-3.95, 5.45])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.44, 95% CI [-7.69, 12.57], t(2008) = 0.47, p = 0.637; Std. beta =
## -6.21e-03, 95% CI [-0.69, 0.68])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.52, 95% CI [-19.12, 4.07], t(2008) = -1.27, p = 0.203; Std. beta = -0.44,
## 95% CI [-1.24, 0.35])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.86, 0.12], t(2008) = -1.95, p = 0.052; Std. beta = -1.75,
## 95% CI [-4.20, 0.71])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-28.20, 24.10], t(2008) = -0.15, p = 0.878; Std. beta = -0.13,
## 95% CI [-1.74, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.57, 95% CI [-11.49, 12.63], t(2008) = 0.09, p = 0.926; Std. beta = 0.41,
## 95% CI [-0.36, 1.18])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.95, 95% CI [-6.96, 20.85], t(2008) = 0.98, p = 0.327; Std. beta = 0.60, 95%
## CI [-0.37, 1.57])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -7.97, 95% CI [-21.26, 5.32], t(2008) = -1.18, p = 0.239; Std. beta = -0.78,
## 95% CI [-1.77, 0.21])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -3.79, 95% CI [-13.99, 6.41], t(2008) = -0.73, p = 0.466; Std. beta = -0.03,
## 95% CI [-0.72, 0.67])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.82, 95% CI [-28.71, 3.07], t(2008) = -1.58, p = 0.114; Std. beta = 0.21,
## 95% CI [-0.90, 1.32])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.66, 95% CI [-8.00, 15.33], t(2008) = 0.62, p = 0.538; Std. beta = 0.76, 95%
## CI [-0.06, 1.57])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-12.11, 13.76], t(2008) = 0.12, p = 0.901; Std. beta = 0.03,
## 95% CI [-0.83, 0.88])
## - The effect of site [38R] is statistically non-significant and positive (beta
## = 7.66e-03, 95% CI [-9.25, 9.26], t(2008) = 1.62e-03, p = 0.999; Std. beta =
## -0.03, 95% CI [-0.65, 0.58])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 16.05, 95% CI [-10.63, 42.72], t(2008) = 1.18, p = 0.238; Std. beta = -1.66,
## 95% CI [-3.79, 0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.82, 95% CI [-17.39, 19.04], t(2008) = 0.09, p = 0.929; Std. beta = 0.35,
## 95% CI [-0.95, 1.66])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-28.55, 2.56], t(2008) = -1.64, p = 0.102; Std. beta = -0.30,
## 95% CI [-1.64, 1.03])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.87, 95% CI [-18.67, -1.07], t(2008) = -2.20, p = 0.028; Std. beta = -0.90,
## 95% CI [-1.94, 0.15])
## - The effect of time firstPFT × NH4 5yrPreDx is statistically non-significant
## and positive (beta = 1.65, 95% CI [-0.34, 3.63], t(2008) = 1.62, p = 0.105;
## Std. beta = 0.12, 95% CI [-0.02, 0.26])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.51, 3.82], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.05, 95% CI [-0.02, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.74, 95% CI [-2.91, 1.42], t(2008) =
## -0.67, p = 0.501; Std. beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.81, 1.77], t(2008) = 0.73, p = 0.466; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.09, 0.04], t(2008) = -0.73, p = 0.463; Std.
## beta = -0.02, 95% CI [-0.09, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.92, 0.68], t(2008) =
## -0.94, p = 0.349; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.28, 95% CI [-18.09, 5.53], t(2008) =
## -1.04, p = 0.297; Std. beta = -0.68, 95% CI [-1.95, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 1.81, 95% CI [-1.45, 5.07], t(2008) =
## 1.09, p = 0.276; Std. beta = 0.19, 95% CI [-0.16, 0.55])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -30.87, 95% CI [-67.33, 5.59], t(2008) = -1.66, p = 0.097;
## Std. beta = -3.32, 95% CI [-7.25, 0.60])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-10.82, 13.04], t(2008) = 0.18, p = 0.855; Std.
## beta = 0.12, 95% CI [-1.16, 1.40])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.40, 95% CI [-13.75, 10.94], t(2008) = -0.22, p = 0.823;
## Std. beta = -0.15, 95% CI [-1.48, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-17.92, 11.72], t(2008) = -0.41, p = 0.682;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-4.03, 2.34], t(2008) = -0.52, p = 0.602; Std.
## beta = -0.09, 95% CI [-0.43, 0.25])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-4.90, 11.94], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.38, 95% CI [-0.53, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.83, 95% CI [-2.05, 3.72], t(2008) = 0.57, p = 0.572; Std.
## beta = 0.09, 95% CI [-0.22, 0.40])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-3.76, 6.13], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.13, 95% CI [-0.40, 0.66])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 4.01, 95% CI [0.48, 7.54], t(2008) = 2.23, p = 0.026; Std.
## beta = 0.43, 95% CI [0.05, 0.81])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 4.37, 95% CI [-3.57, 12.31], t(2008) = 1.08, p = 0.280; Std.
## beta = 0.47, 95% CI [-0.38, 1.32])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-1.31, 4.60], t(2008) = 1.09, p = 0.276; Std.
## beta = 0.18, 95% CI [-0.14, 0.49])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 3.37, 95% CI [-0.32, 7.07], t(2008) = 1.79, p = 0.074; Std.
## beta = 0.36, 95% CI [-0.03, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -10.70, 95% CI [-26.85, 5.45], t(2008) = -1.30, p = 0.194;
## Std. beta = -1.15, 95% CI [-2.89, 0.59])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.96, 95% CI [-0.66, 14.57], t(2008) = 1.79, p = 0.073; Std.
## beta = 0.75, 95% CI [-0.07, 1.57])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 7.50, 95% CI [1.53, 13.46], t(2008) = 2.46, p = 0.014; Std.
## beta = 0.81, 95% CI [0.16, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-5.48, 10.20], t(2008) = 0.59, p = 0.555; Std.
## beta = 0.25, 95% CI [-0.59, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-6.81, 9.16], t(2008) = 0.29, p = 0.773; Std.
## beta = 0.13, 95% CI [-0.73, 0.99])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.82, 95% CI [-55.31, 37.67], t(2008) = -0.37, p = 0.710;
## Std. beta = -0.95, 95% CI [-5.95, 4.06])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-28.98, 26.59], t(2008) = -0.08, p = 0.933;
## Std. beta = -0.13, 95% CI [-3.12, 2.86])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -9.74e-03, 95% CI [-5.42, 5.40], t(2008) = -3.53e-03, p =
## 0.997; Std. beta = -1.05e-03, 95% CI [-0.58, 0.58])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -8.94, 95% CI [-34.48, 16.60], t(2008) = -0.69, p = 0.492;
## Std. beta = -0.96, 95% CI [-3.71, 1.79])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.15, 95% CI [-3.83, 10.12], t(2008) = 0.89, p = 0.376; Std.
## beta = 0.34, 95% CI [-0.41, 1.09])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 2.33, 95% CI [-4.64, 9.29], t(2008) = 0.66, p = 0.513; Std.
## beta = 0.25, 95% CI [-0.50, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 7.54, 95% CI [-1.89, 16.97], t(2008) = 1.57, p = 0.117; Std.
## beta = 0.81, 95% CI [-0.20, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.46, 95% CI [0.85, 12.07], t(2008) = 2.26, p = 0.024; Std.
## beta = 0.70, 95% CI [0.09, 1.30])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.45, 95% CI [-28.14, 77.05], t(2008) = 0.91, p = 0.362; Std.
## beta = 2.63, 95% CI [-3.03, 8.29])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-6.87, 3.35], t(2008) = -0.67, p = 0.500; Std.
## beta = -0.19, 95% CI [-0.74, 0.36])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-5.68, 6.99], t(2008) = 0.20, p = 0.840; Std.
## beta = 0.07, 95% CI [-0.61, 0.75])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -7.29, 95% CI [-33.08, 18.49], t(2008) = -0.55, p = 0.579;
## Std. beta = -0.79, 95% CI [-3.56, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-10.06, 10.19], t(2008) = 0.01, p = 0.990; Std.
## beta = 7.16e-03, 95% CI [-1.08, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 3.82, 95% CI [-0.66, 8.30], t(2008) = 1.67, p = 0.094; Std.
## beta = 0.41, 95% CI [-0.07, 0.89])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-6.09, 8.81], t(2008) = 0.36, p = 0.720; Std.
## beta = 0.15, 95% CI [-0.66, 0.95])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-10.05, 5.11], t(2008) = -0.64, p = 0.523; Std.
## beta = -0.27, 95% CI [-1.08, 0.55])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-2.59, 7.30], t(2008) = 0.93, p = 0.351; Std.
## beta = 0.25, 95% CI [-0.28, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 11.08, 95% CI [1.70, 20.45], t(2008) = 2.32, p = 0.021; Std.
## beta = 1.19, 95% CI [0.18, 2.20])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.25, 95% CI [-0.53, 11.03], t(2008) = 1.78, p = 0.075; Std.
## beta = 0.57, 95% CI [-0.06, 1.19])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.31, 95% CI [-6.15, 5.53], t(2008) = -0.10, p = 0.917; Std.
## beta = -0.03, 95% CI [-0.66, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-4.57, 3.84], t(2008) = -0.17, p = 0.866; Std.
## beta = -0.04, 95% CI [-0.49, 0.41])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.21, 95% CI [-48.93, -7.50], t(2008) = -2.67, p = 0.008;
## Std. beta = -3.04, 95% CI [-5.27, -0.81])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 3.04, 95% CI [-6.11, 12.19], t(2008) = 0.65, p = 0.515; Std.
## beta = 0.33, 95% CI [-0.66, 1.31])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-7.30, 19.11], t(2008) = 0.88, p = 0.380; Std.
## beta = 0.64, 95% CI [-0.79, 2.06])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-14.07, 9.35], t(2008) = -0.40, p = 0.693; Std.
## beta = -0.25, 95% CI [-1.51, 1.01])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*BC_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14849.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1565 -0.4963 -0.0133 0.4353 7.1030
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 143.87 11.995
## time_firstPFT 11.15 3.339 -0.31
## Residual 41.69 6.457
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 44.480082 3.169033 14.036
## time_firstPFT -6.865645 1.621727 -4.234
## BC_5yrPreDx -4.593939 3.405253 -1.349
## site02R -3.220113 13.635412 -0.236
## site03R 24.770583 9.913462 2.499
## site04R -6.169487 9.303543 -0.663
## site05R -12.632898 7.771942 -1.625
## site06R 5.107770 9.687997 0.527
## site07R 4.328565 3.817352 1.134
## site09R -9.330293 9.459376 -0.986
## site101 18.502639 2.855008 6.481
## site102 7.042570 5.177548 1.360
## site103 -3.657537 2.632725 -1.389
## site104 -11.919975 5.555302 -2.146
## site105 0.209331 2.781229 0.075
## site106 -4.802350 3.508972 -1.369
## site107 9.028253 9.689878 0.932
## site108 -10.319631 7.797435 -1.323
## site10R -0.779834 13.447223 -0.058
## site11R 3.056246 6.415194 0.476
## site12R -10.283584 9.428664 -1.091
## site13R -10.589095 7.335747 -1.443
## site14R -7.648047 15.012736 -0.509
## site15R -22.032015 13.686831 -1.610
## site16R -7.810068 5.895226 -1.325
## site17R 58.481291 13.686287 4.273
## site18R -5.690954 9.694326 -0.587
## site19R -8.131629 5.859839 -1.388
## site20R -3.821021 5.637356 -0.678
## site21R -11.924553 12.746335 -0.936
## site22R -11.493630 4.283940 -2.683
## site23R -19.995971 6.228464 -3.210
## site24R 1.137771 5.141303 0.221
## site25R -6.944409 5.617425 -1.236
## site28R -16.444045 7.931412 -2.073
## site29R -0.798386 13.384604 -0.060
## site31R -0.605208 5.834394 -0.104
## site32R 4.088301 6.771689 0.604
## site33R -9.628710 6.693286 -1.439
## site34R -6.041965 5.138010 -1.176
## site35R -15.145143 7.980202 -1.898
## site36R 4.159832 5.963269 0.698
## site37R 1.732608 6.512063 0.266
## site38R -2.043431 4.460260 -0.458
## site39R 4.651762 13.399225 0.347
## site40R 3.029493 9.342283 0.324
## site41R -14.005963 7.751568 -1.807
## site42R -9.115738 4.368155 -2.087
## time_firstPFT:BC_5yrPreDx 2.777071 1.728735 1.606
## time_firstPFT:site02R -33.911442 18.523666 -1.831
## time_firstPFT:site03R -0.873785 5.935685 -0.147
## time_firstPFT:site04R -1.183279 6.267332 -0.189
## time_firstPFT:site05R -3.502767 7.544863 -0.464
## time_firstPFT:site06R 3.000778 5.041036 0.595
## time_firstPFT:site07R -1.888772 1.498161 -1.261
## time_firstPFT:site09R 1.283855 4.215003 0.305
## time_firstPFT:site101 0.046739 1.251437 0.037
## time_firstPFT:site102 -0.431112 2.294717 -0.188
## time_firstPFT:site103 2.393362 1.200233 1.994
## time_firstPFT:site104 3.522416 3.784452 0.931
## time_firstPFT:site105 0.674273 1.215289 0.555
## time_firstPFT:site106 2.070531 1.681657 1.231
## time_firstPFT:site107 -12.411101 8.178969 -1.517
## time_firstPFT:site108 5.425562 3.546702 1.530
## time_firstPFT:site11R 4.932287 2.810100 1.755
## time_firstPFT:site12R 1.947758 4.023612 0.484
## time_firstPFT:site13R 0.009604 3.957177 0.002
## time_firstPFT:site14R -10.285302 23.668442 -0.435
## time_firstPFT:site15R -2.812293 14.145898 -0.199
## time_firstPFT:site16R -0.965099 2.627966 -0.367
## time_firstPFT:site18R -10.170784 12.973880 -0.784
## time_firstPFT:site19R 2.256720 3.399240 0.664
## time_firstPFT:site20R 1.637062 3.432298 0.477
## time_firstPFT:site21R 5.033615 4.754798 1.059
## time_firstPFT:site22R 4.639025 2.778077 1.670
## time_firstPFT:site23R -0.134625 5.400951 -0.025
## time_firstPFT:site24R -2.692207 2.534991 -1.062
## time_firstPFT:site25R -1.230370 3.038809 -0.405
## time_firstPFT:site28R -9.565826 13.062288 -0.732
## time_firstPFT:site29R -2.029348 5.118379 -0.396
## time_firstPFT:site31R 1.773849 1.993681 0.890
## time_firstPFT:site32R -0.816709 3.557707 -0.230
## time_firstPFT:site33R -2.435491 3.804529 -0.640
## time_firstPFT:site34R 1.612355 2.432431 0.663
## time_firstPFT:site35R 9.670304 4.680694 2.066
## time_firstPFT:site36R 4.690350 2.952553 1.589
## time_firstPFT:site37R -1.416830 2.849688 -0.497
## time_firstPFT:site38R -1.686998 1.913568 -0.882
## time_firstPFT:site39R -28.959093 10.454804 -2.770
## time_firstPFT:site40R 2.884936 4.650263 0.620
## time_firstPFT:site41R 4.090369 6.657936 0.614
## time_firstPFT:site42R -2.564667 5.931390 -0.432##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.793
## Unadjusted ICC: 0.539report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## BC_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.32. The model's
## intercept, corresponding to time_firstPFT = 0, is at 44.48 (95% CI [38.27,
## 50.69], t(2038) = 14.04, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.87, 95% CI [-10.05, -3.69], t(2038) = -4.23, p < .001; Std. beta = -0.53,
## 95% CI [-0.65, -0.41])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -4.59, 95% CI [-11.27, 2.08], t(2038) = -1.35, p = 0.177; Std. beta = -0.01,
## 95% CI [-0.13, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-29.96, 23.52], t(2038) = -0.24, p = 0.813; Std. beta = -3.51,
## 95% CI [-6.72, -0.29])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.77, 95% CI [5.33, 44.21], t(2038) = 2.50, p = 0.013; Std. beta = 1.59, 95%
## CI [0.36, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-24.41, 12.08], t(2038) = -0.66, p = 0.507; Std. beta = -0.53,
## 95% CI [-1.93, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.63, 95% CI [-27.87, 2.61], t(2038) = -1.63, p = 0.104; Std. beta = -1.19,
## 95% CI [-2.61, 0.23])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.11, 95% CI [-13.89, 24.11], t(2038) = 0.53, p = 0.598; Std. beta = 0.64,
## 95% CI [-0.70, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-3.16, 11.81], t(2038) = 1.13, p = 0.257; Std. beta = 0.11, 95%
## CI [-0.37, 0.59])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.33, 95% CI [-27.88, 9.22], t(2038) = -0.99, p = 0.324; Std. beta = -0.51,
## 95% CI [-1.75, 0.74])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.50, 95% CI [12.90, 24.10], t(2038) = 6.48, p < .001; Std. beta = 1.26, 95%
## CI [0.88, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.04, 95% CI [-3.11, 17.20], t(2038) = 1.36, p = 0.174; Std. beta = 0.43, 95%
## CI [-0.23, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-8.82, 1.51], t(2038) = -1.39, p = 0.165; Std. beta = -0.02,
## 95% CI [-0.37, 0.33])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.92, 95% CI [-22.81, -1.03], t(2038) = -2.15, p = 0.032; Std. beta = -0.46,
## 95% CI [-1.33, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.21, 95% CI [-5.25, 5.66], t(2038) = 0.08, p = 0.940; Std. beta = 0.08, 95%
## CI [-0.28, 0.44])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.80, 95% CI [-11.68, 2.08], t(2038) = -1.37, p = 0.171; Std. beta = -0.12,
## 95% CI [-0.57, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.03, 95% CI [-9.97, 28.03], t(2038) = 0.93, p = 0.352; Std. beta = -0.59,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-25.61, 4.97], t(2038) = -1.32, p = 0.186; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-27.15, 25.59], t(2038) = -0.06, p = 0.954; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-9.52, 15.64], t(2038) = 0.48, p = 0.634; Std. beta = 0.68, 95%
## CI [-0.16, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.28, 95% CI [-28.77, 8.21], t(2038) = -1.09, p = 0.276; Std. beta = -0.51,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.59, 95% CI [-24.98, 3.80], t(2038) = -1.44, p = 0.149; Std. beta = -0.71,
## 95% CI [-1.65, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.65, 95% CI [-37.09, 21.79], t(2038) = -0.51, p = 0.611; Std. beta = -1.51,
## 95% CI [-4.68, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.03, 95% CI [-48.87, 4.81], t(2038) = -1.61, p = 0.108; Std. beta = -1.76,
## 95% CI [-4.26, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.81, 95% CI [-19.37, 3.75], t(2038) = -1.32, p = 0.185; Std. beta = -0.62,
## 95% CI [-1.41, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.48, 95% CI [31.64, 85.32], t(2038) = 4.27, p < .001; Std. beta = 3.95, 95%
## CI [2.14, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-24.70, 13.32], t(2038) = -0.59, p = 0.557; Std. beta = -1.37,
## 95% CI [-3.76, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.62, 3.36], t(2038) = -1.39, p = 0.165; Std. beta = -0.33,
## 95% CI [-1.15, 0.49])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-14.88, 7.23], t(2038) = -0.68, p = 0.498; Std. beta = -0.10,
## 95% CI [-0.90, 0.70])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.92, 13.07], t(2038) = -0.94, p = 0.350; Std. beta =
## -0.32, 95% CI [-1.88, 1.25])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.49, 95% CI [-19.89, -3.09], t(2038) = -2.68, p = 0.007; Std. beta = -0.33,
## 95% CI [-0.94, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.00, 95% CI [-32.21, -7.78], t(2038) = -3.21, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.48, -0.24])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-8.94, 11.22], t(2038) = 0.22, p = 0.825; Std. beta = -0.18,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-17.96, 4.07], t(2038) = -1.24, p = 0.217; Std. beta = -0.59,
## 95% CI [-1.33, 0.16])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-32.00, -0.89], t(2038) = -2.07, p = 0.038; Std. beta = -2.04,
## 95% CI [-4.46, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-27.05, 25.45], t(2038) = -0.06, p = 0.952; Std. beta = -0.25,
## 95% CI [-1.85, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-12.05, 10.84], t(2038) = -0.10, p = 0.917; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-9.19, 17.37], t(2038) = 0.60, p = 0.546; Std. beta = 0.20, 95%
## CI [-0.71, 1.11])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-22.76, 3.50], t(2038) = -1.44, p = 0.150; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-16.12, 4.03], t(2038) = -1.18, p = 0.240; Std. beta = -0.25,
## 95% CI [-0.93, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.15, 95% CI [-30.80, 0.51], t(2038) = -1.90, p = 0.058; Std. beta = -0.09,
## 95% CI [-1.17, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.53, 15.85], t(2038) = 0.70, p = 0.486; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.73, 95% CI [-11.04, 14.50], t(2038) = 0.27, p = 0.790; Std. beta = -0.02,
## 95% CI [-0.85, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-10.79, 6.70], t(2038) = -0.46, p = 0.647; Std. beta = -0.30,
## 95% CI [-0.87, 0.27])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.65, 95% CI [-21.63, 30.93], t(2038) = 0.35, p = 0.729; Std. beta = -2.49,
## 95% CI [-4.58, -0.41])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-15.29, 21.35], t(2038) = 0.32, p = 0.746; Std. beta = 0.48,
## 95% CI [-0.82, 1.79])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-29.21, 1.20], t(2038) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.86, 0.76])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.12, 95% CI [-17.68, -0.55], t(2038) = -2.09, p = 0.037; Std. beta = -0.86,
## 95% CI [-1.89, 0.16])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.78, 95% CI [-0.61, 6.17], t(2038) = 1.61, p = 0.108;
## Std. beta = 0.08, 95% CI [-0.02, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.91, 95% CI [-70.24, 2.42], t(2038) = -1.83, p = 0.067;
## Std. beta = -3.65, 95% CI [-7.55, 0.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-12.51, 10.77], t(2038) = -0.15, p = 0.883;
## Std. beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-13.47, 11.11], t(2038) = -0.19, p = 0.850;
## Std. beta = -0.13, 95% CI [-1.45, 1.19])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-18.30, 11.29], t(2038) = -0.46, p = 0.643;
## Std. beta = -0.38, 95% CI [-1.97, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-6.89, 12.89], t(2038) = 0.60, p = 0.552; Std.
## beta = 0.32, 95% CI [-0.74, 1.39])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-4.83, 1.05], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.20, 95% CI [-0.52, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-6.98, 9.55], t(2038) = 0.30, p = 0.761; Std.
## beta = 0.14, 95% CI [-0.75, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-2.41, 2.50], t(2038) = 0.04, p = 0.970; Std.
## beta = 5.02e-03, 95% CI [-0.26, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-4.93, 4.07], t(2038) = -0.19, p = 0.851; Std.
## beta = -0.05, 95% CI [-0.53, 0.44])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.39, 95% CI [0.04, 4.75], t(2038) = 1.99, p = 0.046; Std.
## beta = 0.26, 95% CI [4.25e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-3.90, 10.94], t(2038) = 0.93, p = 0.352; Std.
## beta = 0.38, 95% CI [-0.42, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-1.71, 3.06], t(2038) = 0.55, p = 0.579; Std.
## beta = 0.07, 95% CI [-0.18, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.23, 5.37], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.22, 95% CI [-0.13, 0.58])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.45, 3.63], t(2038) = -1.52, p = 0.129;
## Std. beta = -1.33, 95% CI [-3.06, 0.39])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.43, 95% CI [-1.53, 12.38], t(2038) = 1.53, p = 0.126; Std.
## beta = 0.58, 95% CI [-0.16, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-0.58, 10.44], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.53, 95% CI [-0.06, 1.12])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-5.94, 9.84], t(2038) = 0.48, p = 0.628; Std.
## beta = 0.21, 95% CI [-0.64, 1.06])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 9.60e-03, 95% CI [-7.75, 7.77], t(2038) = 2.43e-03, p = 0.998;
## Std. beta = 1.03e-03, 95% CI [-0.83, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.70, 36.13], t(2038) = -0.43, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.10, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.81, 95% CI [-30.55, 24.93], t(2038) = -0.20, p = 0.842;
## Std. beta = -0.30, 95% CI [-3.28, 2.68])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-6.12, 4.19], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.10, 95% CI [-0.66, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.61, 15.27], t(2038) = -0.78, p = 0.433;
## Std. beta = -1.09, 95% CI [-3.83, 1.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-4.41, 8.92], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.24, 95% CI [-0.47, 0.96])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-5.09, 8.37], t(2038) = 0.48, p = 0.633; Std.
## beta = 0.18, 95% CI [-0.55, 0.90])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-4.29, 14.36], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.54, 95% CI [-0.46, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-0.81, 10.09], t(2038) = 1.67, p = 0.095; Std.
## beta = 0.50, 95% CI [-0.09, 1.08])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-10.73, 10.46], t(2038) = -0.02, p = 0.980;
## Std. beta = -0.01, 95% CI [-1.15, 1.12])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-7.66, 2.28], t(2038) = -1.06, p = 0.288; Std.
## beta = -0.29, 95% CI [-0.82, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.19, 4.73], t(2038) = -0.40, p = 0.686; Std.
## beta = -0.13, 95% CI [-0.77, 0.51])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.18, 16.05], t(2038) = -0.73, p = 0.464;
## Std. beta = -1.03, 95% CI [-3.78, 1.73])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-12.07, 8.01], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.22, 95% CI [-1.30, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.14, 5.68], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.19, 95% CI [-0.23, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.79, 6.16], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.09, 95% CI [-0.84, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-9.90, 5.03], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.26, 95% CI [-1.06, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-3.16, 6.38], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.17, 95% CI [-0.34, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.67, 95% CI [0.49, 18.85], t(2038) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.03])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-1.10, 10.48], t(2038) = 1.59, p = 0.112; Std.
## beta = 0.50, 95% CI [-0.12, 1.13])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.42, 95% CI [-7.01, 4.17], t(2038) = -0.50, p = 0.619; Std.
## beta = -0.15, 95% CI [-0.75, 0.45])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-5.44, 2.07], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.18, 95% CI [-0.58, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.96, 95% CI [-49.46, -8.46], t(2038) = -2.77, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.32, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-6.23, 12.00], t(2038) = 0.62, p = 0.535; Std.
## beta = 0.31, 95% CI [-0.67, 1.29])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.09, 95% CI [-8.97, 17.15], t(2038) = 0.61, p = 0.539; Std.
## beta = 0.44, 95% CI [-0.96, 1.84])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-14.20, 9.07], t(2038) = -0.43, p = 0.666; Std.
## beta = -0.28, 95% CI [-1.53, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## BC_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to BC_5yrPreDx = 0, is at 44.48 (95% CI [38.27, 50.69], t(2038) =
## 14.04, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.87, 95% CI [-10.05, -3.69], t(2038) = -4.23, p < .001; Std. beta = -0.53,
## 95% CI [-0.65, -0.41])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -4.59, 95% CI [-11.27, 2.08], t(2038) = -1.35, p = 0.177; Std. beta = -0.01,
## 95% CI [-0.13, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-29.96, 23.52], t(2038) = -0.24, p = 0.813; Std. beta = -3.51,
## 95% CI [-6.72, -0.29])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.77, 95% CI [5.33, 44.21], t(2038) = 2.50, p = 0.013; Std. beta = 1.59, 95%
## CI [0.36, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-24.41, 12.08], t(2038) = -0.66, p = 0.507; Std. beta = -0.53,
## 95% CI [-1.93, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.63, 95% CI [-27.87, 2.61], t(2038) = -1.63, p = 0.104; Std. beta = -1.19,
## 95% CI [-2.61, 0.23])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.11, 95% CI [-13.89, 24.11], t(2038) = 0.53, p = 0.598; Std. beta = 0.64,
## 95% CI [-0.70, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-3.16, 11.81], t(2038) = 1.13, p = 0.257; Std. beta = 0.11, 95%
## CI [-0.37, 0.59])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.33, 95% CI [-27.88, 9.22], t(2038) = -0.99, p = 0.324; Std. beta = -0.51,
## 95% CI [-1.75, 0.74])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.50, 95% CI [12.90, 24.10], t(2038) = 6.48, p < .001; Std. beta = 1.26, 95%
## CI [0.88, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.04, 95% CI [-3.11, 17.20], t(2038) = 1.36, p = 0.174; Std. beta = 0.43, 95%
## CI [-0.23, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-8.82, 1.51], t(2038) = -1.39, p = 0.165; Std. beta = -0.02,
## 95% CI [-0.37, 0.33])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.92, 95% CI [-22.81, -1.03], t(2038) = -2.15, p = 0.032; Std. beta = -0.46,
## 95% CI [-1.33, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.21, 95% CI [-5.25, 5.66], t(2038) = 0.08, p = 0.940; Std. beta = 0.08, 95%
## CI [-0.28, 0.44])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.80, 95% CI [-11.68, 2.08], t(2038) = -1.37, p = 0.171; Std. beta = -0.12,
## 95% CI [-0.57, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.03, 95% CI [-9.97, 28.03], t(2038) = 0.93, p = 0.352; Std. beta = -0.59,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-25.61, 4.97], t(2038) = -1.32, p = 0.186; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-27.15, 25.59], t(2038) = -0.06, p = 0.954; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-9.52, 15.64], t(2038) = 0.48, p = 0.634; Std. beta = 0.68, 95%
## CI [-0.16, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.28, 95% CI [-28.77, 8.21], t(2038) = -1.09, p = 0.276; Std. beta = -0.51,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.59, 95% CI [-24.98, 3.80], t(2038) = -1.44, p = 0.149; Std. beta = -0.71,
## 95% CI [-1.65, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.65, 95% CI [-37.09, 21.79], t(2038) = -0.51, p = 0.611; Std. beta = -1.51,
## 95% CI [-4.68, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.03, 95% CI [-48.87, 4.81], t(2038) = -1.61, p = 0.108; Std. beta = -1.76,
## 95% CI [-4.26, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.81, 95% CI [-19.37, 3.75], t(2038) = -1.32, p = 0.185; Std. beta = -0.62,
## 95% CI [-1.41, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.48, 95% CI [31.64, 85.32], t(2038) = 4.27, p < .001; Std. beta = 3.95, 95%
## CI [2.14, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-24.70, 13.32], t(2038) = -0.59, p = 0.557; Std. beta = -1.37,
## 95% CI [-3.76, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.62, 3.36], t(2038) = -1.39, p = 0.165; Std. beta = -0.33,
## 95% CI [-1.15, 0.49])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-14.88, 7.23], t(2038) = -0.68, p = 0.498; Std. beta = -0.10,
## 95% CI [-0.90, 0.70])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.92, 13.07], t(2038) = -0.94, p = 0.350; Std. beta =
## -0.32, 95% CI [-1.88, 1.25])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.49, 95% CI [-19.89, -3.09], t(2038) = -2.68, p = 0.007; Std. beta = -0.33,
## 95% CI [-0.94, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.00, 95% CI [-32.21, -7.78], t(2038) = -3.21, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.48, -0.24])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-8.94, 11.22], t(2038) = 0.22, p = 0.825; Std. beta = -0.18,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-17.96, 4.07], t(2038) = -1.24, p = 0.217; Std. beta = -0.59,
## 95% CI [-1.33, 0.16])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-32.00, -0.89], t(2038) = -2.07, p = 0.038; Std. beta = -2.04,
## 95% CI [-4.46, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-27.05, 25.45], t(2038) = -0.06, p = 0.952; Std. beta = -0.25,
## 95% CI [-1.85, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-12.05, 10.84], t(2038) = -0.10, p = 0.917; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-9.19, 17.37], t(2038) = 0.60, p = 0.546; Std. beta = 0.20, 95%
## CI [-0.71, 1.11])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-22.76, 3.50], t(2038) = -1.44, p = 0.150; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-16.12, 4.03], t(2038) = -1.18, p = 0.240; Std. beta = -0.25,
## 95% CI [-0.93, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.15, 95% CI [-30.80, 0.51], t(2038) = -1.90, p = 0.058; Std. beta = -0.09,
## 95% CI [-1.17, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.53, 15.85], t(2038) = 0.70, p = 0.486; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.73, 95% CI [-11.04, 14.50], t(2038) = 0.27, p = 0.790; Std. beta = -0.02,
## 95% CI [-0.85, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-10.79, 6.70], t(2038) = -0.46, p = 0.647; Std. beta = -0.30,
## 95% CI [-0.87, 0.27])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.65, 95% CI [-21.63, 30.93], t(2038) = 0.35, p = 0.729; Std. beta = -2.49,
## 95% CI [-4.58, -0.41])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-15.29, 21.35], t(2038) = 0.32, p = 0.746; Std. beta = 0.48,
## 95% CI [-0.82, 1.79])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-29.21, 1.20], t(2038) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.86, 0.76])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.12, 95% CI [-17.68, -0.55], t(2038) = -2.09, p = 0.037; Std. beta = -0.86,
## 95% CI [-1.89, 0.16])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.78, 95% CI [-0.61, 6.17], t(2038) = 1.61, p = 0.108;
## Std. beta = 0.08, 95% CI [-0.02, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.91, 95% CI [-70.24, 2.42], t(2038) = -1.83, p = 0.067;
## Std. beta = -3.65, 95% CI [-7.55, 0.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-12.51, 10.77], t(2038) = -0.15, p = 0.883;
## Std. beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-13.47, 11.11], t(2038) = -0.19, p = 0.850;
## Std. beta = -0.13, 95% CI [-1.45, 1.19])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-18.30, 11.29], t(2038) = -0.46, p = 0.643;
## Std. beta = -0.38, 95% CI [-1.97, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-6.89, 12.89], t(2038) = 0.60, p = 0.552; Std.
## beta = 0.32, 95% CI [-0.74, 1.39])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-4.83, 1.05], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.20, 95% CI [-0.52, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-6.98, 9.55], t(2038) = 0.30, p = 0.761; Std.
## beta = 0.14, 95% CI [-0.75, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-2.41, 2.50], t(2038) = 0.04, p = 0.970; Std.
## beta = 5.02e-03, 95% CI [-0.26, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-4.93, 4.07], t(2038) = -0.19, p = 0.851; Std.
## beta = -0.05, 95% CI [-0.53, 0.44])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.39, 95% CI [0.04, 4.75], t(2038) = 1.99, p = 0.046; Std.
## beta = 0.26, 95% CI [4.25e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-3.90, 10.94], t(2038) = 0.93, p = 0.352; Std.
## beta = 0.38, 95% CI [-0.42, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-1.71, 3.06], t(2038) = 0.55, p = 0.579; Std.
## beta = 0.07, 95% CI [-0.18, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.23, 5.37], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.22, 95% CI [-0.13, 0.58])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.45, 3.63], t(2038) = -1.52, p = 0.129;
## Std. beta = -1.33, 95% CI [-3.06, 0.39])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.43, 95% CI [-1.53, 12.38], t(2038) = 1.53, p = 0.126; Std.
## beta = 0.58, 95% CI [-0.16, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-0.58, 10.44], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.53, 95% CI [-0.06, 1.12])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-5.94, 9.84], t(2038) = 0.48, p = 0.628; Std.
## beta = 0.21, 95% CI [-0.64, 1.06])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 9.60e-03, 95% CI [-7.75, 7.77], t(2038) = 2.43e-03, p = 0.998;
## Std. beta = 1.03e-03, 95% CI [-0.83, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.70, 36.13], t(2038) = -0.43, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.10, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.81, 95% CI [-30.55, 24.93], t(2038) = -0.20, p = 0.842;
## Std. beta = -0.30, 95% CI [-3.28, 2.68])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-6.12, 4.19], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.10, 95% CI [-0.66, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.61, 15.27], t(2038) = -0.78, p = 0.433;
## Std. beta = -1.09, 95% CI [-3.83, 1.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-4.41, 8.92], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.24, 95% CI [-0.47, 0.96])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-5.09, 8.37], t(2038) = 0.48, p = 0.633; Std.
## beta = 0.18, 95% CI [-0.55, 0.90])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-4.29, 14.36], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.54, 95% CI [-0.46, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-0.81, 10.09], t(2038) = 1.67, p = 0.095; Std.
## beta = 0.50, 95% CI [-0.09, 1.08])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-10.73, 10.46], t(2038) = -0.02, p = 0.980;
## Std. beta = -0.01, 95% CI [-1.15, 1.12])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-7.66, 2.28], t(2038) = -1.06, p = 0.288; Std.
## beta = -0.29, 95% CI [-0.82, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.19, 4.73], t(2038) = -0.40, p = 0.686; Std.
## beta = -0.13, 95% CI [-0.77, 0.51])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.18, 16.05], t(2038) = -0.73, p = 0.464;
## Std. beta = -1.03, 95% CI [-3.78, 1.73])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-12.07, 8.01], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.22, 95% CI [-1.30, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.14, 5.68], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.19, 95% CI [-0.23, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.79, 6.16], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.09, 95% CI [-0.84, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-9.90, 5.03], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.26, 95% CI [-1.06, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-3.16, 6.38], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.17, 95% CI [-0.34, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.67, 95% CI [0.49, 18.85], t(2038) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.03])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-1.10, 10.48], t(2038) = 1.59, p = 0.112; Std.
## beta = 0.50, 95% CI [-0.12, 1.13])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.42, 95% CI [-7.01, 4.17], t(2038) = -0.50, p = 0.619; Std.
## beta = -0.15, 95% CI [-0.75, 0.45])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-5.44, 2.07], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.18, 95% CI [-0.58, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.96, 95% CI [-49.46, -8.46], t(2038) = -2.77, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.32, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-6.23, 12.00], t(2038) = 0.62, p = 0.535; Std.
## beta = 0.31, 95% CI [-0.67, 1.29])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.09, 95% CI [-8.97, 17.15], t(2038) = 0.61, p = 0.539; Std.
## beta = 0.44, 95% CI [-0.96, 1.84])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-14.20, 9.07], t(2038) = -0.43, p = 0.666; Std.
## beta = -0.28, 95% CI [-1.53, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.32. The model's intercept, corresponding to site =
## Simmons, is at 44.48 (95% CI [38.27, 50.69], t(2038) = 14.04, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.87, 95% CI [-10.05, -3.69], t(2038) = -4.23, p < .001; Std. beta = -0.53,
## 95% CI [-0.65, -0.41])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -4.59, 95% CI [-11.27, 2.08], t(2038) = -1.35, p = 0.177; Std. beta = -0.01,
## 95% CI [-0.13, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-29.96, 23.52], t(2038) = -0.24, p = 0.813; Std. beta = -3.51,
## 95% CI [-6.72, -0.29])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.77, 95% CI [5.33, 44.21], t(2038) = 2.50, p = 0.013; Std. beta = 1.59, 95%
## CI [0.36, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-24.41, 12.08], t(2038) = -0.66, p = 0.507; Std. beta = -0.53,
## 95% CI [-1.93, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.63, 95% CI [-27.87, 2.61], t(2038) = -1.63, p = 0.104; Std. beta = -1.19,
## 95% CI [-2.61, 0.23])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.11, 95% CI [-13.89, 24.11], t(2038) = 0.53, p = 0.598; Std. beta = 0.64,
## 95% CI [-0.70, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-3.16, 11.81], t(2038) = 1.13, p = 0.257; Std. beta = 0.11, 95%
## CI [-0.37, 0.59])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.33, 95% CI [-27.88, 9.22], t(2038) = -0.99, p = 0.324; Std. beta = -0.51,
## 95% CI [-1.75, 0.74])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.50, 95% CI [12.90, 24.10], t(2038) = 6.48, p < .001; Std. beta = 1.26, 95%
## CI [0.88, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.04, 95% CI [-3.11, 17.20], t(2038) = 1.36, p = 0.174; Std. beta = 0.43, 95%
## CI [-0.23, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-8.82, 1.51], t(2038) = -1.39, p = 0.165; Std. beta = -0.02,
## 95% CI [-0.37, 0.33])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.92, 95% CI [-22.81, -1.03], t(2038) = -2.15, p = 0.032; Std. beta = -0.46,
## 95% CI [-1.33, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.21, 95% CI [-5.25, 5.66], t(2038) = 0.08, p = 0.940; Std. beta = 0.08, 95%
## CI [-0.28, 0.44])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.80, 95% CI [-11.68, 2.08], t(2038) = -1.37, p = 0.171; Std. beta = -0.12,
## 95% CI [-0.57, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.03, 95% CI [-9.97, 28.03], t(2038) = 0.93, p = 0.352; Std. beta = -0.59,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-25.61, 4.97], t(2038) = -1.32, p = 0.186; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-27.15, 25.59], t(2038) = -0.06, p = 0.954; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-9.52, 15.64], t(2038) = 0.48, p = 0.634; Std. beta = 0.68, 95%
## CI [-0.16, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.28, 95% CI [-28.77, 8.21], t(2038) = -1.09, p = 0.276; Std. beta = -0.51,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.59, 95% CI [-24.98, 3.80], t(2038) = -1.44, p = 0.149; Std. beta = -0.71,
## 95% CI [-1.65, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.65, 95% CI [-37.09, 21.79], t(2038) = -0.51, p = 0.611; Std. beta = -1.51,
## 95% CI [-4.68, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.03, 95% CI [-48.87, 4.81], t(2038) = -1.61, p = 0.108; Std. beta = -1.76,
## 95% CI [-4.26, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.81, 95% CI [-19.37, 3.75], t(2038) = -1.32, p = 0.185; Std. beta = -0.62,
## 95% CI [-1.41, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.48, 95% CI [31.64, 85.32], t(2038) = 4.27, p < .001; Std. beta = 3.95, 95%
## CI [2.14, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-24.70, 13.32], t(2038) = -0.59, p = 0.557; Std. beta = -1.37,
## 95% CI [-3.76, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.62, 3.36], t(2038) = -1.39, p = 0.165; Std. beta = -0.33,
## 95% CI [-1.15, 0.49])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-14.88, 7.23], t(2038) = -0.68, p = 0.498; Std. beta = -0.10,
## 95% CI [-0.90, 0.70])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.92, 13.07], t(2038) = -0.94, p = 0.350; Std. beta =
## -0.32, 95% CI [-1.88, 1.25])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.49, 95% CI [-19.89, -3.09], t(2038) = -2.68, p = 0.007; Std. beta = -0.33,
## 95% CI [-0.94, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.00, 95% CI [-32.21, -7.78], t(2038) = -3.21, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.48, -0.24])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-8.94, 11.22], t(2038) = 0.22, p = 0.825; Std. beta = -0.18,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-17.96, 4.07], t(2038) = -1.24, p = 0.217; Std. beta = -0.59,
## 95% CI [-1.33, 0.16])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-32.00, -0.89], t(2038) = -2.07, p = 0.038; Std. beta = -2.04,
## 95% CI [-4.46, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-27.05, 25.45], t(2038) = -0.06, p = 0.952; Std. beta = -0.25,
## 95% CI [-1.85, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-12.05, 10.84], t(2038) = -0.10, p = 0.917; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-9.19, 17.37], t(2038) = 0.60, p = 0.546; Std. beta = 0.20, 95%
## CI [-0.71, 1.11])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-22.76, 3.50], t(2038) = -1.44, p = 0.150; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-16.12, 4.03], t(2038) = -1.18, p = 0.240; Std. beta = -0.25,
## 95% CI [-0.93, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.15, 95% CI [-30.80, 0.51], t(2038) = -1.90, p = 0.058; Std. beta = -0.09,
## 95% CI [-1.17, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.53, 15.85], t(2038) = 0.70, p = 0.486; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.73, 95% CI [-11.04, 14.50], t(2038) = 0.27, p = 0.790; Std. beta = -0.02,
## 95% CI [-0.85, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-10.79, 6.70], t(2038) = -0.46, p = 0.647; Std. beta = -0.30,
## 95% CI [-0.87, 0.27])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.65, 95% CI [-21.63, 30.93], t(2038) = 0.35, p = 0.729; Std. beta = -2.49,
## 95% CI [-4.58, -0.41])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-15.29, 21.35], t(2038) = 0.32, p = 0.746; Std. beta = 0.48,
## 95% CI [-0.82, 1.79])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-29.21, 1.20], t(2038) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.86, 0.76])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.12, 95% CI [-17.68, -0.55], t(2038) = -2.09, p = 0.037; Std. beta = -0.86,
## 95% CI [-1.89, 0.16])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.78, 95% CI [-0.61, 6.17], t(2038) = 1.61, p = 0.108;
## Std. beta = 0.08, 95% CI [-0.02, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.91, 95% CI [-70.24, 2.42], t(2038) = -1.83, p = 0.067;
## Std. beta = -3.65, 95% CI [-7.55, 0.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-12.51, 10.77], t(2038) = -0.15, p = 0.883;
## Std. beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-13.47, 11.11], t(2038) = -0.19, p = 0.850;
## Std. beta = -0.13, 95% CI [-1.45, 1.19])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-18.30, 11.29], t(2038) = -0.46, p = 0.643;
## Std. beta = -0.38, 95% CI [-1.97, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-6.89, 12.89], t(2038) = 0.60, p = 0.552; Std.
## beta = 0.32, 95% CI [-0.74, 1.39])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-4.83, 1.05], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.20, 95% CI [-0.52, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-6.98, 9.55], t(2038) = 0.30, p = 0.761; Std.
## beta = 0.14, 95% CI [-0.75, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-2.41, 2.50], t(2038) = 0.04, p = 0.970; Std.
## beta = 5.02e-03, 95% CI [-0.26, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-4.93, 4.07], t(2038) = -0.19, p = 0.851; Std.
## beta = -0.05, 95% CI [-0.53, 0.44])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.39, 95% CI [0.04, 4.75], t(2038) = 1.99, p = 0.046; Std.
## beta = 0.26, 95% CI [4.25e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-3.90, 10.94], t(2038) = 0.93, p = 0.352; Std.
## beta = 0.38, 95% CI [-0.42, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-1.71, 3.06], t(2038) = 0.55, p = 0.579; Std.
## beta = 0.07, 95% CI [-0.18, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.23, 5.37], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.22, 95% CI [-0.13, 0.58])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.45, 3.63], t(2038) = -1.52, p = 0.129;
## Std. beta = -1.33, 95% CI [-3.06, 0.39])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.43, 95% CI [-1.53, 12.38], t(2038) = 1.53, p = 0.126; Std.
## beta = 0.58, 95% CI [-0.16, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-0.58, 10.44], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.53, 95% CI [-0.06, 1.12])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-5.94, 9.84], t(2038) = 0.48, p = 0.628; Std.
## beta = 0.21, 95% CI [-0.64, 1.06])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 9.60e-03, 95% CI [-7.75, 7.77], t(2038) = 2.43e-03, p = 0.998;
## Std. beta = 1.03e-03, 95% CI [-0.83, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.70, 36.13], t(2038) = -0.43, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.10, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.81, 95% CI [-30.55, 24.93], t(2038) = -0.20, p = 0.842;
## Std. beta = -0.30, 95% CI [-3.28, 2.68])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-6.12, 4.19], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.10, 95% CI [-0.66, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.61, 15.27], t(2038) = -0.78, p = 0.433;
## Std. beta = -1.09, 95% CI [-3.83, 1.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-4.41, 8.92], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.24, 95% CI [-0.47, 0.96])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-5.09, 8.37], t(2038) = 0.48, p = 0.633; Std.
## beta = 0.18, 95% CI [-0.55, 0.90])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-4.29, 14.36], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.54, 95% CI [-0.46, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-0.81, 10.09], t(2038) = 1.67, p = 0.095; Std.
## beta = 0.50, 95% CI [-0.09, 1.08])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-10.73, 10.46], t(2038) = -0.02, p = 0.980;
## Std. beta = -0.01, 95% CI [-1.15, 1.12])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-7.66, 2.28], t(2038) = -1.06, p = 0.288; Std.
## beta = -0.29, 95% CI [-0.82, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.19, 4.73], t(2038) = -0.40, p = 0.686; Std.
## beta = -0.13, 95% CI [-0.77, 0.51])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.18, 16.05], t(2038) = -0.73, p = 0.464;
## Std. beta = -1.03, 95% CI [-3.78, 1.73])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-12.07, 8.01], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.22, 95% CI [-1.30, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.14, 5.68], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.19, 95% CI [-0.23, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.79, 6.16], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.09, 95% CI [-0.84, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-9.90, 5.03], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.26, 95% CI [-1.06, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-3.16, 6.38], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.17, 95% CI [-0.34, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.67, 95% CI [0.49, 18.85], t(2038) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.03])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-1.10, 10.48], t(2038) = 1.59, p = 0.112; Std.
## beta = 0.50, 95% CI [-0.12, 1.13])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.42, 95% CI [-7.01, 4.17], t(2038) = -0.50, p = 0.619; Std.
## beta = -0.15, 95% CI [-0.75, 0.45])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-5.44, 2.07], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.18, 95% CI [-0.58, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.96, 95% CI [-49.46, -8.46], t(2038) = -2.77, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.32, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-6.23, 12.00], t(2038) = 0.62, p = 0.535; Std.
## beta = 0.31, 95% CI [-0.67, 1.29])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.09, 95% CI [-8.97, 17.15], t(2038) = 0.61, p = 0.539; Std.
## beta = 0.44, 95% CI [-0.96, 1.84])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-14.20, 9.07], t(2038) = -0.43, p = 0.666; Std.
## beta = -0.28, 95% CI [-1.53, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to cohort = CARE-PF, is at 44.48 (95% CI [38.27, 50.69], t(2038)
## = 14.04, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.87, 95% CI [-10.05, -3.69], t(2038) = -4.23, p < .001; Std. beta = -0.53,
## 95% CI [-0.65, -0.41])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -4.59, 95% CI [-11.27, 2.08], t(2038) = -1.35, p = 0.177; Std. beta = -0.01,
## 95% CI [-0.13, 0.11])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.22, 95% CI [-29.96, 23.52], t(2038) = -0.24, p = 0.813; Std. beta = -3.51,
## 95% CI [-6.72, -0.29])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.77, 95% CI [5.33, 44.21], t(2038) = 2.50, p = 0.013; Std. beta = 1.59, 95%
## CI [0.36, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-24.41, 12.08], t(2038) = -0.66, p = 0.507; Std. beta = -0.53,
## 95% CI [-1.93, 0.87])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.63, 95% CI [-27.87, 2.61], t(2038) = -1.63, p = 0.104; Std. beta = -1.19,
## 95% CI [-2.61, 0.23])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.11, 95% CI [-13.89, 24.11], t(2038) = 0.53, p = 0.598; Std. beta = 0.64,
## 95% CI [-0.70, 1.97])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-3.16, 11.81], t(2038) = 1.13, p = 0.257; Std. beta = 0.11, 95%
## CI [-0.37, 0.59])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.33, 95% CI [-27.88, 9.22], t(2038) = -0.99, p = 0.324; Std. beta = -0.51,
## 95% CI [-1.75, 0.74])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.50, 95% CI [12.90, 24.10], t(2038) = 6.48, p < .001; Std. beta = 1.26, 95%
## CI [0.88, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.04, 95% CI [-3.11, 17.20], t(2038) = 1.36, p = 0.174; Std. beta = 0.43, 95%
## CI [-0.23, 1.10])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.66, 95% CI [-8.82, 1.51], t(2038) = -1.39, p = 0.165; Std. beta = -0.02,
## 95% CI [-0.37, 0.33])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.92, 95% CI [-22.81, -1.03], t(2038) = -2.15, p = 0.032; Std. beta = -0.46,
## 95% CI [-1.33, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.21, 95% CI [-5.25, 5.66], t(2038) = 0.08, p = 0.940; Std. beta = 0.08, 95%
## CI [-0.28, 0.44])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.80, 95% CI [-11.68, 2.08], t(2038) = -1.37, p = 0.171; Std. beta = -0.12,
## 95% CI [-0.57, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.03, 95% CI [-9.97, 28.03], t(2038) = 0.93, p = 0.352; Std. beta = -0.59,
## 95% CI [-2.16, 0.97])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -10.32, 95% CI [-25.61, 4.97], t(2038) = -1.32, p = 0.186; Std. beta = -0.17,
## 95% CI [-1.16, 0.81])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.78, 95% CI [-27.15, 25.59], t(2038) = -0.06, p = 0.954; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.06, 95% CI [-9.52, 15.64], t(2038) = 0.48, p = 0.634; Std. beta = 0.68, 95%
## CI [-0.16, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.28, 95% CI [-28.77, 8.21], t(2038) = -1.09, p = 0.276; Std. beta = -0.51,
## 95% CI [-1.76, 0.75])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.59, 95% CI [-24.98, 3.80], t(2038) = -1.44, p = 0.149; Std. beta = -0.71,
## 95% CI [-1.65, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.65, 95% CI [-37.09, 21.79], t(2038) = -0.51, p = 0.611; Std. beta = -1.51,
## 95% CI [-4.68, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.03, 95% CI [-48.87, 4.81], t(2038) = -1.61, p = 0.108; Std. beta = -1.76,
## 95% CI [-4.26, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.81, 95% CI [-19.37, 3.75], t(2038) = -1.32, p = 0.185; Std. beta = -0.62,
## 95% CI [-1.41, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.48, 95% CI [31.64, 85.32], t(2038) = 4.27, p < .001; Std. beta = 3.95, 95%
## CI [2.14, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.69, 95% CI [-24.70, 13.32], t(2038) = -0.59, p = 0.557; Std. beta = -1.37,
## 95% CI [-3.76, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.62, 3.36], t(2038) = -1.39, p = 0.165; Std. beta = -0.33,
## 95% CI [-1.15, 0.49])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.82, 95% CI [-14.88, 7.23], t(2038) = -0.68, p = 0.498; Std. beta = -0.10,
## 95% CI [-0.90, 0.70])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.92, 13.07], t(2038) = -0.94, p = 0.350; Std. beta =
## -0.32, 95% CI [-1.88, 1.25])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.49, 95% CI [-19.89, -3.09], t(2038) = -2.68, p = 0.007; Std. beta = -0.33,
## 95% CI [-0.94, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.00, 95% CI [-32.21, -7.78], t(2038) = -3.21, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.48, -0.24])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.14, 95% CI [-8.94, 11.22], t(2038) = 0.22, p = 0.825; Std. beta = -0.18,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.94, 95% CI [-17.96, 4.07], t(2038) = -1.24, p = 0.217; Std. beta = -0.59,
## 95% CI [-1.33, 0.16])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-32.00, -0.89], t(2038) = -2.07, p = 0.038; Std. beta = -2.04,
## 95% CI [-4.46, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-27.05, 25.45], t(2038) = -0.06, p = 0.952; Std. beta = -0.25,
## 95% CI [-1.85, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.61, 95% CI [-12.05, 10.84], t(2038) = -0.10, p = 0.917; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.09, 95% CI [-9.19, 17.37], t(2038) = 0.60, p = 0.546; Std. beta = 0.20, 95%
## CI [-0.71, 1.11])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.63, 95% CI [-22.76, 3.50], t(2038) = -1.44, p = 0.150; Std. beta = -0.89,
## 95% CI [-1.86, 0.09])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-16.12, 4.03], t(2038) = -1.18, p = 0.240; Std. beta = -0.25,
## 95% CI [-0.93, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.15, 95% CI [-30.80, 0.51], t(2038) = -1.90, p = 0.058; Std. beta = -0.09,
## 95% CI [-1.17, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-7.53, 15.85], t(2038) = 0.70, p = 0.486; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.73, 95% CI [-11.04, 14.50], t(2038) = 0.27, p = 0.790; Std. beta = -0.02,
## 95% CI [-0.85, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.04, 95% CI [-10.79, 6.70], t(2038) = -0.46, p = 0.647; Std. beta = -0.30,
## 95% CI [-0.87, 0.27])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.65, 95% CI [-21.63, 30.93], t(2038) = 0.35, p = 0.729; Std. beta = -2.49,
## 95% CI [-4.58, -0.41])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-15.29, 21.35], t(2038) = 0.32, p = 0.746; Std. beta = 0.48,
## 95% CI [-0.82, 1.79])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-29.21, 1.20], t(2038) = -1.81, p = 0.071; Std. beta = -0.55,
## 95% CI [-1.86, 0.76])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.12, 95% CI [-17.68, -0.55], t(2038) = -2.09, p = 0.037; Std. beta = -0.86,
## 95% CI [-1.89, 0.16])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.78, 95% CI [-0.61, 6.17], t(2038) = 1.61, p = 0.108;
## Std. beta = 0.08, 95% CI [-0.02, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.91, 95% CI [-70.24, 2.42], t(2038) = -1.83, p = 0.067;
## Std. beta = -3.65, 95% CI [-7.55, 0.26])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-12.51, 10.77], t(2038) = -0.15, p = 0.883;
## Std. beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-13.47, 11.11], t(2038) = -0.19, p = 0.850;
## Std. beta = -0.13, 95% CI [-1.45, 1.19])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.50, 95% CI [-18.30, 11.29], t(2038) = -0.46, p = 0.643;
## Std. beta = -0.38, 95% CI [-1.97, 1.21])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.00, 95% CI [-6.89, 12.89], t(2038) = 0.60, p = 0.552; Std.
## beta = 0.32, 95% CI [-0.74, 1.39])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-4.83, 1.05], t(2038) = -1.26, p = 0.208; Std.
## beta = -0.20, 95% CI [-0.52, 0.11])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-6.98, 9.55], t(2038) = 0.30, p = 0.761; Std.
## beta = 0.14, 95% CI [-0.75, 1.03])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.05, 95% CI [-2.41, 2.50], t(2038) = 0.04, p = 0.970; Std.
## beta = 5.02e-03, 95% CI [-0.26, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-4.93, 4.07], t(2038) = -0.19, p = 0.851; Std.
## beta = -0.05, 95% CI [-0.53, 0.44])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.39, 95% CI [0.04, 4.75], t(2038) = 1.99, p = 0.046; Std.
## beta = 0.26, 95% CI [4.25e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.52, 95% CI [-3.90, 10.94], t(2038) = 0.93, p = 0.352; Std.
## beta = 0.38, 95% CI [-0.42, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.67, 95% CI [-1.71, 3.06], t(2038) = 0.55, p = 0.579; Std.
## beta = 0.07, 95% CI [-0.18, 0.33])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.23, 5.37], t(2038) = 1.23, p = 0.218; Std.
## beta = 0.22, 95% CI [-0.13, 0.58])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.45, 3.63], t(2038) = -1.52, p = 0.129;
## Std. beta = -1.33, 95% CI [-3.06, 0.39])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.43, 95% CI [-1.53, 12.38], t(2038) = 1.53, p = 0.126; Std.
## beta = 0.58, 95% CI [-0.16, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-0.58, 10.44], t(2038) = 1.76, p = 0.079; Std.
## beta = 0.53, 95% CI [-0.06, 1.12])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.95, 95% CI [-5.94, 9.84], t(2038) = 0.48, p = 0.628; Std.
## beta = 0.21, 95% CI [-0.64, 1.06])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 9.60e-03, 95% CI [-7.75, 7.77], t(2038) = 2.43e-03, p = 0.998;
## Std. beta = 1.03e-03, 95% CI [-0.83, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.70, 36.13], t(2038) = -0.43, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.10, 3.88])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.81, 95% CI [-30.55, 24.93], t(2038) = -0.20, p = 0.842;
## Std. beta = -0.30, 95% CI [-3.28, 2.68])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-6.12, 4.19], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.10, 95% CI [-0.66, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.61, 15.27], t(2038) = -0.78, p = 0.433;
## Std. beta = -1.09, 95% CI [-3.83, 1.64])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-4.41, 8.92], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.24, 95% CI [-0.47, 0.96])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.64, 95% CI [-5.09, 8.37], t(2038) = 0.48, p = 0.633; Std.
## beta = 0.18, 95% CI [-0.55, 0.90])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-4.29, 14.36], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.54, 95% CI [-0.46, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.64, 95% CI [-0.81, 10.09], t(2038) = 1.67, p = 0.095; Std.
## beta = 0.50, 95% CI [-0.09, 1.08])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-10.73, 10.46], t(2038) = -0.02, p = 0.980;
## Std. beta = -0.01, 95% CI [-1.15, 1.12])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-7.66, 2.28], t(2038) = -1.06, p = 0.288; Std.
## beta = -0.29, 95% CI [-0.82, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.19, 4.73], t(2038) = -0.40, p = 0.686; Std.
## beta = -0.13, 95% CI [-0.77, 0.51])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.18, 16.05], t(2038) = -0.73, p = 0.464;
## Std. beta = -1.03, 95% CI [-3.78, 1.73])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-12.07, 8.01], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.22, 95% CI [-1.30, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.77, 95% CI [-2.14, 5.68], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.19, 95% CI [-0.23, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.79, 6.16], t(2038) = -0.23, p = 0.818; Std.
## beta = -0.09, 95% CI [-0.84, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-9.90, 5.03], t(2038) = -0.64, p = 0.522; Std.
## beta = -0.26, 95% CI [-1.06, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-3.16, 6.38], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.17, 95% CI [-0.34, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.67, 95% CI [0.49, 18.85], t(2038) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.03])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-1.10, 10.48], t(2038) = 1.59, p = 0.112; Std.
## beta = 0.50, 95% CI [-0.12, 1.13])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.42, 95% CI [-7.01, 4.17], t(2038) = -0.50, p = 0.619; Std.
## beta = -0.15, 95% CI [-0.75, 0.45])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.69, 95% CI [-5.44, 2.07], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.18, 95% CI [-0.58, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.96, 95% CI [-49.46, -8.46], t(2038) = -2.77, p = 0.006;
## Std. beta = -3.11, 95% CI [-5.32, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.88, 95% CI [-6.23, 12.00], t(2038) = 0.62, p = 0.535; Std.
## beta = 0.31, 95% CI [-0.67, 1.29])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.09, 95% CI [-8.97, 17.15], t(2038) = 0.61, p = 0.539; Std.
## beta = 0.44, 95% CI [-0.96, 1.84])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.56, 95% CI [-14.20, 9.07], t(2038) = -0.43, p = 0.666; Std.
## beta = -0.28, 95% CI [-1.53, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*BC_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14678.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1321 -0.4888 -0.0079 0.4409 7.0974
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 139.17 11.797
## time_firstPFT 11.17 3.342 -0.29
## Residual 41.73 6.460
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 40.88365 5.74293 7.119
## time_firstPFT -4.91502 2.72652 -1.803
## BC_5yrPreDx -3.30704 3.39635 -0.974
## disadv -5.50445 2.33373 -2.359
## dich_RaceNon-White -2.94565 2.28949 -1.287
## sexF -2.43779 1.42628 -1.709
## age_dx 0.13508 0.07442 1.815
## smokeHxFormer -2.74939 1.41406 -1.944
## smokeHxAlways 9.10747 7.08038 1.286
## smokeHxUnknown -3.00455 3.18741 -0.943
## site02R -6.71043 13.52706 -0.496
## site03R 20.61366 9.91234 2.080
## site04R -5.55204 9.19993 -0.603
## site05R -13.01722 7.72050 -1.686
## site06R -7.84077 13.50697 -0.580
## site07R 2.81924 3.80923 0.740
## site09R -11.44363 9.38594 -1.219
## site101 19.03002 2.87503 6.619
## site102 6.33924 5.18000 1.224
## site103 -3.03990 2.72322 -1.116
## site104 -10.19311 5.54862 -1.837
## site105 1.11575 2.79421 0.399
## site106 -6.49112 3.54538 -1.831
## site107 6.92632 9.61265 0.721
## site108 -4.42998 8.09878 -0.547
## site10R 0.05833 13.44071 0.004
## site11R 1.80335 6.36625 0.283
## site12R -8.55061 9.32843 -0.917
## site13R -12.11678 7.29947 -1.660
## site14R -9.39801 14.96759 -0.628
## site15R -19.00934 13.58199 -1.400
## site16R -7.69185 5.92002 -1.299
## site17R 62.89912 13.66640 4.602
## site18R -3.95716 9.62839 -0.411
## site19R -8.16196 5.84222 -1.397
## site20R -3.89681 5.59744 -0.696
## site21R -11.88541 12.58039 -0.945
## site22R -14.00466 4.31832 -3.243
## site23R -26.09020 7.76513 -3.360
## site24R 0.88153 5.09435 0.173
## site25R -9.23274 5.63054 -1.640
## site28R -15.17982 7.89501 -1.923
## site29R -4.06806 13.27191 -0.307
## site31R -1.14467 5.83886 -0.196
## site32R 4.60512 6.74727 0.683
## site33R -9.81404 6.65432 -1.475
## site34R -5.73800 5.09381 -1.126
## site35R -15.36792 7.93070 -1.938
## site36R 3.58025 5.92623 0.604
## site37R 0.05194 6.53515 0.008
## site38R -1.38217 4.42518 -0.312
## site39R 12.94384 13.50688 0.958
## site40R 1.15803 9.26269 0.125
## site41R -14.64213 7.73504 -1.893
## site42R -10.90659 4.37779 -2.491
## time_firstPFT:BC_5yrPreDx 2.04291 1.77937 1.148
## time_firstPFT:disadv 1.31576 1.10642 1.189
## time_firstPFT:dich_RaceNon-White -0.61632 1.11402 -0.553
## time_firstPFT:sexF 0.58291 0.66307 0.879
## time_firstPFT:age_dx -0.03290 0.03461 -0.951
## time_firstPFT:smokeHxFormer -0.65474 0.67515 -0.970
## time_firstPFT:smokeHxAlways -6.02253 6.04713 -0.996
## time_firstPFT:smokeHxUnknown 2.22766 1.66985 1.334
## time_firstPFT:site02R -32.55747 18.54423 -1.756
## time_firstPFT:site03R -0.59877 5.98117 -0.100
## time_firstPFT:site04R -1.96539 6.30820 -0.312
## time_firstPFT:site05R -3.29975 7.56446 -0.436
## time_firstPFT:site07R -1.53854 1.53800 -1.000
## time_firstPFT:site09R 2.26091 4.24891 0.532
## time_firstPFT:site101 -0.00652 1.28005 -0.005
## time_firstPFT:site102 -0.07416 2.31993 -0.032
## time_firstPFT:site103 2.47924 1.27748 1.941
## time_firstPFT:site104 2.85443 3.86022 0.739
## time_firstPFT:site105 0.58814 1.23119 0.478
## time_firstPFT:site106 2.42486 1.73118 1.401
## time_firstPFT:site107 -11.83046 8.19345 -1.444
## time_firstPFT:site108 5.75937 3.76761 1.529
## time_firstPFT:site11R 5.60074 2.87096 1.951
## time_firstPFT:site12R 2.25806 4.05364 0.557
## time_firstPFT:site13R -0.03590 3.99908 -0.009
## time_firstPFT:site14R -9.36950 23.68557 -0.396
## time_firstPFT:site15R -2.78845 14.16658 -0.197
## time_firstPFT:site16R -1.05524 2.69257 -0.392
## time_firstPFT:site18R -10.17075 12.98984 -0.783
## time_firstPFT:site19R 2.08243 3.44916 0.604
## time_firstPFT:site20R 1.26511 3.48136 0.363
## time_firstPFT:site21R 5.71259 4.77476 1.196
## time_firstPFT:site22R 5.73909 2.83030 2.028
## time_firstPFT:site23R 23.86282 26.77390 0.891
## time_firstPFT:site24R -2.51818 2.54889 -0.988
## time_firstPFT:site25R -0.53525 3.10354 -0.172
## time_firstPFT:site28R -8.43216 13.14125 -0.642
## time_firstPFT:site29R -0.76911 5.16008 -0.149
## time_firstPFT:site31R 2.41731 2.04640 1.181
## time_firstPFT:site32R -0.40477 3.60187 -0.112
## time_firstPFT:site33R -3.10599 3.88262 -0.800
## time_firstPFT:site34R 1.59117 2.47865 0.642
## time_firstPFT:site35R 10.14323 4.72993 2.144
## time_firstPFT:site36R 4.88256 2.98190 1.637
## time_firstPFT:site37R -1.04012 2.95990 -0.351
## time_firstPFT:site38R -1.67460 1.92963 -0.868
## time_firstPFT:site39R -29.20771 10.54706 -2.769
## time_firstPFT:site40R 2.32006 4.72970 0.491
## time_firstPFT:site41R 4.80051 6.68522 0.718
## time_firstPFT:site42R -3.03165 5.95234 -0.509##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.791
## Unadjusted ICC: 0.526report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## BC_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 40.88 (95% CI [29.62, 52.15], t(2008)
## = 7.12, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## BC_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to BC_5yrPreDx =
## 0, is at 40.88 (95% CI [29.62, 52.15], t(2008) = 7.12, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to disadv = 0, is at 40.88 (95% CI [29.62,
## 52.15], t(2008) = 7.12, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to dich_Race = White, is at 40.88 (95% CI
## [29.62, 52.15], t(2008) = 7.12, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 40.88 (95% CI [29.62,
## 52.15], t(2008) = 7.12, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to age_dx = 0, is at 40.88 (95% CI [29.62,
## 52.15], t(2008) = 7.12, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to smokeHx = Never, is at 40.88 (95% CI
## [29.62, 52.15], t(2008) = 7.12, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 40.88 (95% CI [29.62,
## 52.15], t(2008) = 7.12, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 40.88 (95% CI [29.62, 52.15], t(2008) = 7.12, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.92, 95% CI [-10.26, 0.43], t(2008) = -1.80, p = 0.072; Std. beta =
## -0.52, 95% CI [-0.70, -0.34])
## - The effect of BC 5yrPreDx is statistically non-significant and negative (beta
## = -3.31, 95% CI [-9.97, 3.35], t(2008) = -0.97, p = 0.330; Std. beta =
## -6.30e-03, 95% CI [-0.13, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.50,
## 95% CI [-10.08, -0.93], t(2008) = -2.36, p = 0.018; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.95, 95% CI [-7.44, 1.54], t(2008) = -1.29, p = 0.198; Std.
## beta = -0.26, 95% CI [-0.57, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.23, 0.36], t(2008) = -1.71, p = 0.088; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.070; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.75, 95% CI [-5.52, 0.02], t(2008) = -1.94, p = 0.052; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.11, 95% CI [-4.78, 22.99], t(2008) = 1.29, p = 0.198; Std. beta =
## 0.03, 95% CI [-1.18, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -3.00, 95% CI [-9.26, 3.25], t(2008) = -0.94, p = 0.346; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.71, 95% CI [-33.24, 19.82], t(2008) = -0.50, p = 0.620; Std. beta = -3.62,
## 95% CI [-6.84, -0.39])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.61, 95% CI [1.17, 40.05], t(2008) = 2.08, p = 0.038; Std. beta = 1.33, 95%
## CI [0.09, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.55, 95% CI [-23.59, 12.49], t(2008) = -0.60, p = 0.546; Std. beta = -0.57,
## 95% CI [-1.97, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.16, 2.12], t(2008) = -1.69, p = 0.092; Std. beta = -1.20,
## 95% CI [-2.63, 0.23])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.84, 95% CI [-34.33, 18.65], t(2008) = -0.58, p = 0.562; Std. beta = -0.53,
## 95% CI [-2.32, 1.26])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.65, 10.29], t(2008) = 0.74, p = 0.459; Std. beta = 0.04, 95%
## CI [-0.44, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.44, 95% CI [-29.85, 6.96], t(2008) = -1.22, p = 0.223; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.03, 95% CI [13.39, 24.67], t(2008) = 6.62, p < .001; Std. beta = 1.28, 95%
## CI [0.90, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.34, 95% CI [-3.82, 16.50], t(2008) = 1.22, p = 0.221; Std. beta = 0.42, 95%
## CI [-0.25, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -3.04, 95% CI [-8.38, 2.30], t(2008) = -1.12, p = 0.264; Std. beta = 0.04,
## 95% CI [-0.33, 0.40])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.19, 95% CI [-21.07, 0.69], t(2008) = -1.84, p = 0.066; Std. beta = -0.41,
## 95% CI [-1.29, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.12, 95% CI [-4.36, 6.60], t(2008) = 0.40, p = 0.690; Std. beta = 0.13, 95%
## CI [-0.23, 0.50])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.49, 95% CI [-13.44, 0.46], t(2008) = -1.83, p = 0.067; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.93, 95% CI [-11.93, 25.78], t(2008) = 0.72, p = 0.471; Std. beta = -0.68,
## 95% CI [-2.25, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.43, 95% CI [-20.31, 11.45], t(2008) = -0.55, p = 0.584; Std. beta = 0.26,
## 95% CI [-0.78, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-26.30, 26.42], t(2008) = 4.34e-03, p = 0.997; Std. beta =
## 3.94e-03, 95% CI [-1.78, 1.78])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.80, 95% CI [-10.68, 14.29], t(2008) = 0.28, p = 0.777; Std. beta = 0.67,
## 95% CI [-0.18, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-26.85, 9.74], t(2008) = -0.92, p = 0.359; Std. beta = -0.36,
## 95% CI [-1.61, 0.90])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.12, 95% CI [-26.43, 2.20], t(2008) = -1.66, p = 0.097; Std. beta = -0.82,
## 95% CI [-1.76, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-38.75, 19.96], t(2008) = -0.63, p = 0.530; Std. beta = -1.55,
## 95% CI [-4.73, 1.64])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.01, 95% CI [-45.65, 7.63], t(2008) = -1.40, p = 0.162; Std. beta = -1.55,
## 95% CI [-4.06, 0.95])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -7.69, 95% CI [-19.30, 3.92], t(2008) = -1.30, p = 0.194; Std. beta = -0.62,
## 95% CI [-1.42, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.90, 95% CI [36.10, 89.70], t(2008) = 4.60, p < .001; Std. beta = 4.25, 95%
## CI [2.44, 6.06])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-22.84, 14.93], t(2008) = -0.41, p = 0.681; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.16, 95% CI [-19.62, 3.30], t(2008) = -1.40, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.18, 0.48])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.90, 95% CI [-14.87, 7.08], t(2008) = -0.70, p = 0.486; Std. beta = -0.14,
## 95% CI [-0.94, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.89, 95% CI [-36.56, 12.79], t(2008) = -0.94, p = 0.345; Std. beta =
## -0.25, 95% CI [-1.81, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.00, 95% CI [-22.47, -5.54], t(2008) = -3.24, p = 0.001; Std. beta = -0.39,
## 95% CI [-1.02, 0.24])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.09, 95% CI [-41.32, -10.86], t(2008) = -3.36, p < .001; Std. beta = 0.56,
## 95% CI [-4.13, 5.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-9.11, 10.87], t(2008) = 0.17, p = 0.863; Std. beta = -0.19,
## 95% CI [-0.86, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-20.28, 1.81], t(2008) = -1.64, p = 0.101; Std. beta = -0.68,
## 95% CI [-1.43, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.18, 95% CI [-30.66, 0.30], t(2008) = -1.92, p = 0.055; Std. beta = -1.85,
## 95% CI [-4.30, 0.61])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.07, 95% CI [-30.10, 21.96], t(2008) = -0.31, p = 0.759; Std. beta = -0.35,
## 95% CI [-1.95, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.14, 95% CI [-12.60, 10.31], t(2008) = -0.20, p = 0.845; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.61, 95% CI [-8.63, 17.84], t(2008) = 0.68, p = 0.495; Std. beta = 0.27, 95%
## CI [-0.65, 1.19])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-22.86, 3.24], t(2008) = -1.47, p = 0.140; Std. beta = -0.96,
## 95% CI [-1.95, 0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.74, 95% CI [-15.73, 4.25], t(2008) = -1.13, p = 0.260; Std. beta = -0.23,
## 95% CI [-0.91, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.92, 0.19], t(2008) = -1.94, p = 0.053; Std. beta = -0.05,
## 95% CI [-1.14, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.58, 95% CI [-8.04, 15.20], t(2008) = 0.60, p = 0.546; Std. beta = 0.72, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.05, 95% CI [-12.76, 12.87], t(2008) = 7.95e-03, p = 0.994; Std. beta =
## -0.10, 95% CI [-0.94, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.38, 95% CI [-10.06, 7.30], t(2008) = -0.31, p = 0.755; Std. beta = -0.26,
## 95% CI [-0.83, 0.31])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.94, 95% CI [-13.55, 39.43], t(2008) = 0.96, p = 0.338; Std. beta = -1.97,
## 95% CI [-4.08, 0.15])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.16, 95% CI [-17.01, 19.32], t(2008) = 0.13, p = 0.901; Std. beta = 0.30,
## 95% CI [-1.01, 1.61])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.64, 95% CI [-29.81, 0.53], t(2008) = -1.89, p = 0.059; Std. beta = -0.52,
## 95% CI [-1.84, 0.79])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.91, 95% CI [-19.49, -2.32], t(2008) = -2.49, p = 0.013; Std. beta = -1.03,
## 95% CI [-2.07, 7.29e-03])
## - The effect of time firstPFT × BC 5yrPreDx is statistically non-significant
## and positive (beta = 2.04, 95% CI [-1.45, 5.53], t(2008) = 1.15, p = 0.251;
## Std. beta = 0.06, 95% CI [-0.04, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.32, 95% CI [-0.85, 3.49], t(2008) = 1.19, p = 0.235; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-2.80, 1.57], t(2008) =
## -0.55, p = 0.580; Std. beta = -0.07, 95% CI [-0.30, 0.17])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.58, 95% CI [-0.72, 1.88], t(2008) = 0.88, p = 0.379; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.95, p = 0.342; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.65, 95% CI [-1.98, 0.67], t(2008) =
## -0.97, p = 0.332; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.02, 95% CI [-17.88, 5.84], t(2008) =
## -1.00, p = 0.319; Std. beta = -0.65, 95% CI [-1.92, 0.63])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.23, 95% CI [-1.05, 5.50], t(2008) =
## 1.33, p = 0.182; Std. beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-68.93, 3.81], t(2008) = -1.76, p = 0.079;
## Std. beta = -3.50, 95% CI [-7.42, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.60, 95% CI [-12.33, 11.13], t(2008) = -0.10, p = 0.920;
## Std. beta = -0.06, 95% CI [-1.33, 1.20])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-14.34, 10.41], t(2008) = -0.31, p = 0.755;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.30, 95% CI [-18.13, 11.54], t(2008) = -0.44, p = 0.663;
## Std. beta = -0.36, 95% CI [-1.95, 1.24])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-4.55, 1.48], t(2008) = -1.00, p = 0.317; Std.
## beta = -0.17, 95% CI [-0.49, 0.16])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-6.07, 10.59], t(2008) = 0.53, p = 0.595; Std.
## beta = 0.24, 95% CI [-0.65, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -6.52e-03, 95% CI [-2.52, 2.50], t(2008) = -5.09e-03, p =
## 0.996; Std. beta = -7.03e-04, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-4.62, 4.48], t(2008) = -0.03, p = 0.975; Std.
## beta = -7.98e-03, 95% CI [-0.50, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-0.03, 4.98], t(2008) = 1.94, p = 0.052; Std.
## beta = 0.27, 95% CI [-2.81e-03, 0.54])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.72, 10.42], t(2008) = 0.74, p = 0.460; Std.
## beta = 0.31, 95% CI [-0.51, 1.12])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.59, 95% CI [-1.83, 3.00], t(2008) = 0.48, p = 0.633; Std.
## beta = 0.06, 95% CI [-0.20, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-0.97, 5.82], t(2008) = 1.40, p = 0.161; Std.
## beta = 0.26, 95% CI [-0.10, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.83, 95% CI [-27.90, 4.24], t(2008) = -1.44, p = 0.149;
## Std. beta = -1.27, 95% CI [-3.00, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.76, 95% CI [-1.63, 13.15], t(2008) = 1.53, p = 0.127; Std.
## beta = 0.62, 95% CI [-0.18, 1.42])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-0.03, 11.23], t(2008) = 1.95, p = 0.051; Std.
## beta = 0.60, 95% CI [-3.19e-03, 1.21])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-5.69, 10.21], t(2008) = 0.56, p = 0.578; Std.
## beta = 0.24, 95% CI [-0.61, 1.10])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-7.88, 7.81], t(2008) = -8.98e-03, p = 0.993;
## Std. beta = -3.87e-03, 95% CI [-0.85, 0.84])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.37, 95% CI [-55.82, 37.08], t(2008) = -0.40, p = 0.692;
## Std. beta = -1.01, 95% CI [-6.01, 3.99])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-30.57, 24.99], t(2008) = -0.20, p = 0.844;
## Std. beta = -0.30, 95% CI [-3.29, 2.69])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.34, 4.23], t(2008) = -0.39, p = 0.695; Std.
## beta = -0.11, 95% CI [-0.68, 0.45])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.17, 95% CI [-35.65, 15.30], t(2008) = -0.78, p = 0.434;
## Std. beta = -1.09, 95% CI [-3.84, 1.65])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-4.68, 8.85], t(2008) = 0.60, p = 0.546; Std.
## beta = 0.22, 95% CI [-0.50, 0.95])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-5.56, 8.09], t(2008) = 0.36, p = 0.716; Std.
## beta = 0.14, 95% CI [-0.60, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.71, 95% CI [-3.65, 15.08], t(2008) = 1.20, p = 0.232; Std.
## beta = 0.61, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.74, 95% CI [0.19, 11.29], t(2008) = 2.03, p = 0.043; Std.
## beta = 0.62, 95% CI [0.02, 1.22])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.86, 95% CI [-28.64, 76.37], t(2008) = 0.89, p = 0.373; Std.
## beta = 2.57, 95% CI [-3.08, 8.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-7.52, 2.48], t(2008) = -0.99, p = 0.323; Std.
## beta = -0.27, 95% CI [-0.81, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.54, 95% CI [-6.62, 5.55], t(2008) = -0.17, p = 0.863; Std.
## beta = -0.06, 95% CI [-0.71, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.43, 95% CI [-34.20, 17.34], t(2008) = -0.64, p = 0.521;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-10.89, 9.35], t(2008) = -0.15, p = 0.882; Std.
## beta = -0.08, 95% CI [-1.17, 1.01])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-1.60, 6.43], t(2008) = 1.18, p = 0.238; Std.
## beta = 0.26, 95% CI [-0.17, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.47, 6.66], t(2008) = -0.11, p = 0.911; Std.
## beta = -0.04, 95% CI [-0.80, 0.72])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.72, 4.51], t(2008) = -0.80, p = 0.424; Std.
## beta = -0.33, 95% CI [-1.15, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.27, 6.45], t(2008) = 0.64, p = 0.521; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.14, 95% CI [0.87, 19.42], t(2008) = 2.14, p = 0.032; Std.
## beta = 1.09, 95% CI [0.09, 2.09])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.88, 95% CI [-0.97, 10.73], t(2008) = 1.64, p = 0.102; Std.
## beta = 0.53, 95% CI [-0.10, 1.16])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.04, 95% CI [-6.84, 4.76], t(2008) = -0.35, p = 0.725; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-5.46, 2.11], t(2008) = -0.87, p = 0.386; Std.
## beta = -0.18, 95% CI [-0.59, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.21, 95% CI [-49.89, -8.52], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.14, 95% CI [-5.37, -0.92])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.32, 95% CI [-6.96, 11.60], t(2008) = 0.49, p = 0.624; Std.
## beta = 0.25, 95% CI [-0.75, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.80, 95% CI [-8.31, 17.91], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-14.71, 8.64], t(2008) = -0.51, p = 0.611; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*OM_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14850.2
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1470 -0.4999 -0.0103 0.4403 7.0993
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 141.37 11.890
## time_firstPFT 10.75 3.279 -0.29
## Residual 41.70 6.458
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 45.9882 2.3268 19.764
## time_firstPFT -6.8446 1.0615 -6.448
## OM_5yrPreDx -1.6265 0.6132 -2.652
## site02R -2.4532 13.5110 -0.182
## site03R 25.8071 9.8370 2.623
## site04R -6.5376 9.2258 -0.709
## site05R -13.1287 7.7203 -1.701
## site06R 7.3530 9.6660 0.761
## site07R 4.2844 3.6980 1.159
## site09R -9.3373 9.3694 -0.997
## site101 18.8924 2.5558 7.392
## site102 8.4636 4.9077 1.725
## site103 -2.3626 2.1573 -1.095
## site104 -11.4001 5.2037 -2.191
## site105 2.3170 2.4718 0.937
## site106 -4.1680 3.3530 -1.243
## site107 10.3254 9.5415 1.082
## site108 -9.5463 7.4839 -1.276
## site10R -1.6708 13.3992 -0.125
## site11R 3.9283 6.3744 0.616
## site12R -10.7872 9.3186 -1.158
## site13R -10.7247 7.2639 -1.476
## site14R -8.5486 14.9605 -0.571
## site15R -22.1467 13.5718 -1.632
## site16R -8.7667 5.8498 -1.499
## site17R 58.7296 13.5728 4.327
## site18R -5.3899 9.5998 -0.561
## site19R -8.9091 5.6481 -1.577
## site20R -4.0920 5.5533 -0.737
## site21R -11.9161 12.6419 -0.943
## site22R -12.3995 4.2662 -2.906
## site23R -19.6379 6.1020 -3.218
## site24R 1.2568 5.0167 0.251
## site25R -6.0029 5.5178 -1.088
## site28R -16.4408 7.8702 -2.089
## site29R -1.6494 13.2649 -0.124
## site31R -0.7934 5.7594 -0.138
## site32R 3.7257 6.6578 0.560
## site33R -9.7959 6.5883 -1.487
## site34R -6.0373 4.9951 -1.209
## site35R -14.9956 7.8090 -1.920
## site36R 4.6561 5.9234 0.786
## site37R 1.5164 6.4575 0.235
## site38R -1.8628 4.3994 -0.423
## site39R 4.1626 13.2370 0.314
## site40R 2.7699 9.2407 0.300
## site41R -13.8613 7.6727 -1.807
## site42R -9.5478 4.3294 -2.205
## time_firstPFT:OM_5yrPreDx 0.7156 0.2792 2.563
## time_firstPFT:site02R -34.4798 18.5084 -1.863
## time_firstPFT:site03R -1.4259 5.9188 -0.241
## time_firstPFT:site04R -1.2355 6.2388 -0.198
## time_firstPFT:site05R -3.3103 7.5377 -0.439
## time_firstPFT:site06R 1.9718 5.0374 0.391
## time_firstPFT:site07R -2.1152 1.4070 -1.503
## time_firstPFT:site09R 0.8657 4.1773 0.207
## time_firstPFT:site101 -0.4888 1.0683 -0.458
## time_firstPFT:site102 -1.5400 2.1514 -0.716
## time_firstPFT:site103 1.4063 0.9424 1.492
## time_firstPFT:site104 2.6432 3.7065 0.713
## time_firstPFT:site105 -0.6140 1.0644 -0.577
## time_firstPFT:site106 1.5831 1.5939 0.993
## time_firstPFT:site107 -13.3324 8.1374 -1.638
## time_firstPFT:site108 4.6226 3.3682 1.372
## time_firstPFT:site11R 4.5438 2.7905 1.628
## time_firstPFT:site12R 1.8410 3.9713 0.464
## time_firstPFT:site13R -0.1625 3.9136 -0.042
## time_firstPFT:site14R -10.1075 23.6678 -0.427
## time_firstPFT:site15R -2.5813 14.1284 -0.183
## time_firstPFT:site16R -0.7617 2.6012 -0.293
## time_firstPFT:site18R -10.4685 12.9656 -0.807
## time_firstPFT:site19R 2.1501 3.2896 0.654
## time_firstPFT:site20R 1.4719 3.3861 0.435
## time_firstPFT:site21R 5.1090 4.7099 1.085
## time_firstPFT:site22R 4.9187 2.7672 1.778
## time_firstPFT:site23R -0.5865 5.3559 -0.109
## time_firstPFT:site24R -3.0520 2.4621 -1.240
## time_firstPFT:site25R -1.8196 2.9516 -0.616
## time_firstPFT:site28R -9.6151 13.0620 -0.736
## time_firstPFT:site29R -1.9564 5.0536 -0.387
## time_firstPFT:site31R 1.6819 1.9420 0.866
## time_firstPFT:site32R -0.9151 3.5284 -0.259
## time_firstPFT:site33R -2.5162 3.7412 -0.673
## time_firstPFT:site34R 1.2449 2.3490 0.530
## time_firstPFT:site35R 9.2703 4.5944 2.018
## time_firstPFT:site36R 4.5107 2.9352 1.537
## time_firstPFT:site37R -1.4673 2.8252 -0.519
## time_firstPFT:site38R -1.9100 1.8766 -1.018
## time_firstPFT:site39R -29.1424 10.4093 -2.800
## time_firstPFT:site40R 2.7177 4.5624 0.596
## time_firstPFT:site41R 3.8712 6.6396 0.583
## time_firstPFT:site42R -2.5349 5.9211 -0.428##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.792
## Unadjusted ICC: 0.541report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## OM_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.32. The model's
## intercept, corresponding to time_firstPFT = 0, is at 45.99 (95% CI [41.42,
## 50.55], t(2038) = 19.76, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.84, 95% CI [-8.93, -4.76], t(2038) = -6.45, p < .001; Std. beta = -0.49, 95%
## CI [-0.59, -0.39])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.63, 95% CI [-2.83, -0.42], t(2038) = -2.65, p = 0.008; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-28.95, 24.04], t(2038) = -0.18, p = 0.856; Std. beta = -3.51,
## 95% CI [-6.72, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.81, 95% CI [6.52, 45.10], t(2038) = 2.62, p = 0.009; Std. beta = 1.61, 95%
## CI [0.37, 2.84])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-24.63, 11.56], t(2038) = -0.71, p = 0.479; Std. beta = -0.56,
## 95% CI [-1.96, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.13, 95% CI [-28.27, 2.01], t(2038) = -1.70, p = 0.089; Std. beta = -1.21,
## 95% CI [-2.63, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.35, 95% CI [-11.60, 26.31], t(2038) = 0.76, p = 0.447; Std. beta = 0.69,
## 95% CI [-0.65, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.28, 95% CI [-2.97, 11.54], t(2038) = 1.16, p = 0.247; Std. beta = 0.08, 95%
## CI [-0.38, 0.55])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.34, 95% CI [-27.71, 9.04], t(2038) = -1.00, p = 0.319; Std. beta = -0.55,
## 95% CI [-1.79, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.89, 95% CI [13.88, 23.90], t(2038) = 7.39, p < .001; Std. beta = 1.23, 95%
## CI [0.90, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.46, 95% CI [-1.16, 18.09], t(2038) = 1.72, p = 0.085; Std. beta = 0.42, 95%
## CI [-0.21, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.36, 95% CI [-6.59, 1.87], t(2038) = -1.10, p = 0.274; Std. beta = -0.02,
## 95% CI [-0.31, 0.26])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.40, 95% CI [-21.61, -1.19], t(2038) = -2.19, p = 0.029; Std. beta = -0.51,
## 95% CI [-1.35, 0.32])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.32, 95% CI [-2.53, 7.16], t(2038) = 0.94, p = 0.349; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-10.74, 2.41], t(2038) = -1.24, p = 0.214; Std. beta = -0.13,
## 95% CI [-0.56, 0.30])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-8.39, 29.04], t(2038) = 1.08, p = 0.279; Std. beta = -0.59,
## 95% CI [-2.15, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.55, 95% CI [-24.22, 5.13], t(2038) = -1.28, p = 0.202; Std. beta = -0.20,
## 95% CI [-1.14, 0.75])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.67, 95% CI [-27.95, 24.61], t(2038) = -0.12, p = 0.901; Std. beta = -0.11,
## 95% CI [-1.89, 1.66])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-8.57, 16.43], t(2038) = 0.62, p = 0.538; Std. beta = 0.71, 95%
## CI [-0.14, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.79, 95% CI [-29.06, 7.49], t(2038) = -1.16, p = 0.247; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.72, 95% CI [-24.97, 3.52], t(2038) = -1.48, p = 0.140; Std. beta = -0.74,
## 95% CI [-1.67, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-37.89, 20.79], t(2038) = -0.57, p = 0.568; Std. beta = -1.56,
## 95% CI [-4.73, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.15, 95% CI [-48.76, 4.47], t(2038) = -1.63, p = 0.103; Std. beta = -1.75,
## 95% CI [-4.24, 0.75])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.77, 95% CI [-20.24, 2.71], t(2038) = -1.50, p = 0.134; Std. beta = -0.67,
## 95% CI [-1.45, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.73, 95% CI [32.11, 85.35], t(2038) = 4.33, p < .001; Std. beta = 3.97, 95%
## CI [2.17, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.39, 95% CI [-24.22, 13.44], t(2038) = -0.56, p = 0.575; Std. beta = -1.38,
## 95% CI [-3.77, 1.01])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.91, 95% CI [-19.99, 2.17], t(2038) = -1.58, p = 0.115; Std. beta = -0.39,
## 95% CI [-1.19, 0.40])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.09, 95% CI [-14.98, 6.80], t(2038) = -0.74, p = 0.461; Std. beta = -0.13,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.71, 12.88], t(2038) = -0.94, p = 0.346; Std. beta =
## -0.31, 95% CI [-1.88, 1.26])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.40, 95% CI [-20.77, -4.03], t(2038) = -2.91, p = 0.004; Std. beta = -0.36,
## 95% CI [-0.98, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.64, 95% CI [-31.60, -7.67], t(2038) = -3.22, p = 0.001; Std. beta = -1.38,
## 95% CI [-2.49, -0.27])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.58, 11.10], t(2038) = 0.25, p = 0.802; Std. beta = -0.21,
## 95% CI [-0.87, 0.45])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-16.82, 4.82], t(2038) = -1.09, p = 0.277; Std. beta = -0.58,
## 95% CI [-1.31, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-31.88, -1.01], t(2038) = -2.09, p = 0.037; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.65, 95% CI [-27.66, 24.36], t(2038) = -0.12, p = 0.901; Std. beta = -0.30,
## 95% CI [-1.89, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-12.09, 10.50], t(2038) = -0.14, p = 0.890; Std. beta = 0.11,
## 95% CI [-0.60, 0.82])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-9.33, 16.78], t(2038) = 0.56, p = 0.576; Std. beta = 0.16, 95%
## CI [-0.74, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.80, 95% CI [-22.72, 3.12], t(2038) = -1.49, p = 0.137; Std. beta = -0.91,
## 95% CI [-1.87, 0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-15.83, 3.76], t(2038) = -1.21, p = 0.227; Std. beta = -0.29,
## 95% CI [-0.95, 0.37])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.00, 95% CI [-30.31, 0.32], t(2038) = -1.92, p = 0.055; Std. beta = -0.12,
## 95% CI [-1.18, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.66, 95% CI [-6.96, 16.27], t(2038) = 0.79, p = 0.432; Std. beta = 0.75, 95%
## CI [-0.06, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.15, 14.18], t(2038) = 0.23, p = 0.814; Std. beta = -0.04,
## 95% CI [-0.87, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-10.49, 6.76], t(2038) = -0.42, p = 0.672; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-21.80, 30.12], t(2038) = 0.31, p = 0.753; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-15.35, 20.89], t(2038) = 0.30, p = 0.764; Std. beta = 0.45,
## 95% CI [-0.84, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.86, 95% CI [-28.91, 1.19], t(2038) = -1.81, p = 0.071; Std. beta = -0.56,
## 95% CI [-1.87, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.55, 95% CI [-18.04, -1.06], t(2038) = -2.21, p = 0.028; Std. beta = -0.89,
## 95% CI [-1.92, 0.14])
## - The effect of time firstPFT × OM 5yrPreDx is statistically significant and
## positive (beta = 0.72, 95% CI [0.17, 1.26], t(2038) = 2.56, p = 0.010; Std.
## beta = 0.09, 95% CI [0.02, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.48, 95% CI [-70.78, 1.82], t(2038) = -1.86, p = 0.063;
## Std. beta = -3.71, 95% CI [-7.61, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-13.03, 10.18], t(2038) = -0.24, p = 0.810;
## Std. beta = -0.15, 95% CI [-1.40, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-13.47, 11.00], t(2038) = -0.20, p = 0.843;
## Std. beta = -0.13, 95% CI [-1.45, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-18.09, 11.47], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.36, 95% CI [-1.95, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-7.91, 11.85], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.21, 95% CI [-0.85, 1.27])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-4.87, 0.64], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.23, 95% CI [-0.52, 0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-7.33, 9.06], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.09, 95% CI [-0.79, 0.97])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-2.58, 1.61], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.05, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.76, 2.68], t(2038) = -0.72, p = 0.474; Std.
## beta = -0.17, 95% CI [-0.62, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.44, 3.25], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.15, 95% CI [-0.05, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.63, 9.91], t(2038) = 0.71, p = 0.476; Std.
## beta = 0.28, 95% CI [-0.50, 1.07])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.47], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-1.54, 4.71], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.17, 95% CI [-0.17, 0.51])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.33, 95% CI [-29.29, 2.63], t(2038) = -1.64, p = 0.101;
## Std. beta = -1.43, 95% CI [-3.15, 0.28])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.98, 11.23], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.50, 95% CI [-0.21, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.54, 95% CI [-0.93, 10.02], t(2038) = 1.63, p = 0.104; Std.
## beta = 0.49, 95% CI [-0.10, 1.08])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.95, 9.63], t(2038) = 0.46, p = 0.643; Std.
## beta = 0.20, 95% CI [-0.64, 1.04])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-7.84, 7.51], t(2038) = -0.04, p = 0.967; Std.
## beta = -0.02, 95% CI [-0.84, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.11, 95% CI [-56.52, 36.31], t(2038) = -0.43, p = 0.669;
## Std. beta = -1.09, 95% CI [-6.08, 3.90])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-30.29, 25.13], t(2038) = -0.18, p = 0.855;
## Std. beta = -0.28, 95% CI [-3.26, 2.70])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.86, 4.34], t(2038) = -0.29, p = 0.770; Std.
## beta = -0.08, 95% CI [-0.63, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.90, 14.96], t(2038) = -0.81, p = 0.420;
## Std. beta = -1.13, 95% CI [-3.86, 1.61])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.30, 8.60], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.23, 95% CI [-0.46, 0.92])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-5.17, 8.11], t(2038) = 0.43, p = 0.664; Std.
## beta = 0.16, 95% CI [-0.56, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-4.13, 14.35], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.55, 95% CI [-0.44, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.92, 95% CI [-0.51, 10.35], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.53, 95% CI [-0.05, 1.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-11.09, 9.92], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.06, 95% CI [-1.19, 1.07])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.88, 1.78], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.33, 95% CI [-0.85, 0.19])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.82, 95% CI [-7.61, 3.97], t(2038) = -0.62, p = 0.538; Std.
## beta = -0.20, 95% CI [-0.82, 0.43])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.23, 16.00], t(2038) = -0.74, p = 0.462;
## Std. beta = -1.03, 95% CI [-3.79, 1.72])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.96, 95% CI [-11.87, 7.95], t(2038) = -0.39, p = 0.699; Std.
## beta = -0.21, 95% CI [-1.28, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-2.13, 5.49], t(2038) = 0.87, p = 0.387; Std.
## beta = 0.18, 95% CI [-0.23, 0.59])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-7.83, 6.00], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.10, 95% CI [-0.84, 0.65])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-9.85, 4.82], t(2038) = -0.67, p = 0.501; Std.
## beta = -0.27, 95% CI [-1.06, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-3.36, 5.85], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.13, 95% CI [-0.36, 0.63])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.26, 18.28], t(2038) = 2.02, p = 0.044; Std.
## beta = 1.00, 95% CI [0.03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.51, 95% CI [-1.25, 10.27], t(2038) = 1.54, p = 0.125; Std.
## beta = 0.48, 95% CI [-0.13, 1.10])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-7.01, 4.07], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.75, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.91, 95% CI [-5.59, 1.77], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.21, 95% CI [-0.60, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.14, 95% CI [-49.56, -8.73], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.13, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-6.23, 11.67], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.29, 95% CI [-0.67, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-9.15, 16.89], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.42, 95% CI [-0.98, 1.82])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.15, 9.08], t(2038) = -0.43, p = 0.669; Std.
## beta = -0.27, 95% CI [-1.52, 0.98])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## OM_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to OM_5yrPreDx = 0, is at 45.99 (95% CI [41.42, 50.55], t(2038) =
## 19.76, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.84, 95% CI [-8.93, -4.76], t(2038) = -6.45, p < .001; Std. beta = -0.49, 95%
## CI [-0.59, -0.39])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.63, 95% CI [-2.83, -0.42], t(2038) = -2.65, p = 0.008; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-28.95, 24.04], t(2038) = -0.18, p = 0.856; Std. beta = -3.51,
## 95% CI [-6.72, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.81, 95% CI [6.52, 45.10], t(2038) = 2.62, p = 0.009; Std. beta = 1.61, 95%
## CI [0.37, 2.84])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-24.63, 11.56], t(2038) = -0.71, p = 0.479; Std. beta = -0.56,
## 95% CI [-1.96, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.13, 95% CI [-28.27, 2.01], t(2038) = -1.70, p = 0.089; Std. beta = -1.21,
## 95% CI [-2.63, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.35, 95% CI [-11.60, 26.31], t(2038) = 0.76, p = 0.447; Std. beta = 0.69,
## 95% CI [-0.65, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.28, 95% CI [-2.97, 11.54], t(2038) = 1.16, p = 0.247; Std. beta = 0.08, 95%
## CI [-0.38, 0.55])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.34, 95% CI [-27.71, 9.04], t(2038) = -1.00, p = 0.319; Std. beta = -0.55,
## 95% CI [-1.79, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.89, 95% CI [13.88, 23.90], t(2038) = 7.39, p < .001; Std. beta = 1.23, 95%
## CI [0.90, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.46, 95% CI [-1.16, 18.09], t(2038) = 1.72, p = 0.085; Std. beta = 0.42, 95%
## CI [-0.21, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.36, 95% CI [-6.59, 1.87], t(2038) = -1.10, p = 0.274; Std. beta = -0.02,
## 95% CI [-0.31, 0.26])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.40, 95% CI [-21.61, -1.19], t(2038) = -2.19, p = 0.029; Std. beta = -0.51,
## 95% CI [-1.35, 0.32])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.32, 95% CI [-2.53, 7.16], t(2038) = 0.94, p = 0.349; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-10.74, 2.41], t(2038) = -1.24, p = 0.214; Std. beta = -0.13,
## 95% CI [-0.56, 0.30])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-8.39, 29.04], t(2038) = 1.08, p = 0.279; Std. beta = -0.59,
## 95% CI [-2.15, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.55, 95% CI [-24.22, 5.13], t(2038) = -1.28, p = 0.202; Std. beta = -0.20,
## 95% CI [-1.14, 0.75])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.67, 95% CI [-27.95, 24.61], t(2038) = -0.12, p = 0.901; Std. beta = -0.11,
## 95% CI [-1.89, 1.66])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-8.57, 16.43], t(2038) = 0.62, p = 0.538; Std. beta = 0.71, 95%
## CI [-0.14, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.79, 95% CI [-29.06, 7.49], t(2038) = -1.16, p = 0.247; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.72, 95% CI [-24.97, 3.52], t(2038) = -1.48, p = 0.140; Std. beta = -0.74,
## 95% CI [-1.67, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-37.89, 20.79], t(2038) = -0.57, p = 0.568; Std. beta = -1.56,
## 95% CI [-4.73, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.15, 95% CI [-48.76, 4.47], t(2038) = -1.63, p = 0.103; Std. beta = -1.75,
## 95% CI [-4.24, 0.75])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.77, 95% CI [-20.24, 2.71], t(2038) = -1.50, p = 0.134; Std. beta = -0.67,
## 95% CI [-1.45, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.73, 95% CI [32.11, 85.35], t(2038) = 4.33, p < .001; Std. beta = 3.97, 95%
## CI [2.17, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.39, 95% CI [-24.22, 13.44], t(2038) = -0.56, p = 0.575; Std. beta = -1.38,
## 95% CI [-3.77, 1.01])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.91, 95% CI [-19.99, 2.17], t(2038) = -1.58, p = 0.115; Std. beta = -0.39,
## 95% CI [-1.19, 0.40])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.09, 95% CI [-14.98, 6.80], t(2038) = -0.74, p = 0.461; Std. beta = -0.13,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.71, 12.88], t(2038) = -0.94, p = 0.346; Std. beta =
## -0.31, 95% CI [-1.88, 1.26])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.40, 95% CI [-20.77, -4.03], t(2038) = -2.91, p = 0.004; Std. beta = -0.36,
## 95% CI [-0.98, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.64, 95% CI [-31.60, -7.67], t(2038) = -3.22, p = 0.001; Std. beta = -1.38,
## 95% CI [-2.49, -0.27])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.58, 11.10], t(2038) = 0.25, p = 0.802; Std. beta = -0.21,
## 95% CI [-0.87, 0.45])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-16.82, 4.82], t(2038) = -1.09, p = 0.277; Std. beta = -0.58,
## 95% CI [-1.31, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-31.88, -1.01], t(2038) = -2.09, p = 0.037; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.65, 95% CI [-27.66, 24.36], t(2038) = -0.12, p = 0.901; Std. beta = -0.30,
## 95% CI [-1.89, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-12.09, 10.50], t(2038) = -0.14, p = 0.890; Std. beta = 0.11,
## 95% CI [-0.60, 0.82])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-9.33, 16.78], t(2038) = 0.56, p = 0.576; Std. beta = 0.16, 95%
## CI [-0.74, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.80, 95% CI [-22.72, 3.12], t(2038) = -1.49, p = 0.137; Std. beta = -0.91,
## 95% CI [-1.87, 0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-15.83, 3.76], t(2038) = -1.21, p = 0.227; Std. beta = -0.29,
## 95% CI [-0.95, 0.37])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.00, 95% CI [-30.31, 0.32], t(2038) = -1.92, p = 0.055; Std. beta = -0.12,
## 95% CI [-1.18, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.66, 95% CI [-6.96, 16.27], t(2038) = 0.79, p = 0.432; Std. beta = 0.75, 95%
## CI [-0.06, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.15, 14.18], t(2038) = 0.23, p = 0.814; Std. beta = -0.04,
## 95% CI [-0.87, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-10.49, 6.76], t(2038) = -0.42, p = 0.672; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-21.80, 30.12], t(2038) = 0.31, p = 0.753; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-15.35, 20.89], t(2038) = 0.30, p = 0.764; Std. beta = 0.45,
## 95% CI [-0.84, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.86, 95% CI [-28.91, 1.19], t(2038) = -1.81, p = 0.071; Std. beta = -0.56,
## 95% CI [-1.87, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.55, 95% CI [-18.04, -1.06], t(2038) = -2.21, p = 0.028; Std. beta = -0.89,
## 95% CI [-1.92, 0.14])
## - The effect of time firstPFT × OM 5yrPreDx is statistically significant and
## positive (beta = 0.72, 95% CI [0.17, 1.26], t(2038) = 2.56, p = 0.010; Std.
## beta = 0.09, 95% CI [0.02, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.48, 95% CI [-70.78, 1.82], t(2038) = -1.86, p = 0.063;
## Std. beta = -3.71, 95% CI [-7.61, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-13.03, 10.18], t(2038) = -0.24, p = 0.810;
## Std. beta = -0.15, 95% CI [-1.40, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-13.47, 11.00], t(2038) = -0.20, p = 0.843;
## Std. beta = -0.13, 95% CI [-1.45, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-18.09, 11.47], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.36, 95% CI [-1.95, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-7.91, 11.85], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.21, 95% CI [-0.85, 1.27])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-4.87, 0.64], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.23, 95% CI [-0.52, 0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-7.33, 9.06], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.09, 95% CI [-0.79, 0.97])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-2.58, 1.61], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.05, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.76, 2.68], t(2038) = -0.72, p = 0.474; Std.
## beta = -0.17, 95% CI [-0.62, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.44, 3.25], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.15, 95% CI [-0.05, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.63, 9.91], t(2038) = 0.71, p = 0.476; Std.
## beta = 0.28, 95% CI [-0.50, 1.07])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.47], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-1.54, 4.71], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.17, 95% CI [-0.17, 0.51])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.33, 95% CI [-29.29, 2.63], t(2038) = -1.64, p = 0.101;
## Std. beta = -1.43, 95% CI [-3.15, 0.28])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.98, 11.23], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.50, 95% CI [-0.21, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.54, 95% CI [-0.93, 10.02], t(2038) = 1.63, p = 0.104; Std.
## beta = 0.49, 95% CI [-0.10, 1.08])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.95, 9.63], t(2038) = 0.46, p = 0.643; Std.
## beta = 0.20, 95% CI [-0.64, 1.04])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-7.84, 7.51], t(2038) = -0.04, p = 0.967; Std.
## beta = -0.02, 95% CI [-0.84, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.11, 95% CI [-56.52, 36.31], t(2038) = -0.43, p = 0.669;
## Std. beta = -1.09, 95% CI [-6.08, 3.90])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-30.29, 25.13], t(2038) = -0.18, p = 0.855;
## Std. beta = -0.28, 95% CI [-3.26, 2.70])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.86, 4.34], t(2038) = -0.29, p = 0.770; Std.
## beta = -0.08, 95% CI [-0.63, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.90, 14.96], t(2038) = -0.81, p = 0.420;
## Std. beta = -1.13, 95% CI [-3.86, 1.61])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.30, 8.60], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.23, 95% CI [-0.46, 0.92])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-5.17, 8.11], t(2038) = 0.43, p = 0.664; Std.
## beta = 0.16, 95% CI [-0.56, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-4.13, 14.35], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.55, 95% CI [-0.44, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.92, 95% CI [-0.51, 10.35], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.53, 95% CI [-0.05, 1.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-11.09, 9.92], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.06, 95% CI [-1.19, 1.07])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.88, 1.78], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.33, 95% CI [-0.85, 0.19])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.82, 95% CI [-7.61, 3.97], t(2038) = -0.62, p = 0.538; Std.
## beta = -0.20, 95% CI [-0.82, 0.43])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.23, 16.00], t(2038) = -0.74, p = 0.462;
## Std. beta = -1.03, 95% CI [-3.79, 1.72])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.96, 95% CI [-11.87, 7.95], t(2038) = -0.39, p = 0.699; Std.
## beta = -0.21, 95% CI [-1.28, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-2.13, 5.49], t(2038) = 0.87, p = 0.387; Std.
## beta = 0.18, 95% CI [-0.23, 0.59])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-7.83, 6.00], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.10, 95% CI [-0.84, 0.65])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-9.85, 4.82], t(2038) = -0.67, p = 0.501; Std.
## beta = -0.27, 95% CI [-1.06, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-3.36, 5.85], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.13, 95% CI [-0.36, 0.63])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.26, 18.28], t(2038) = 2.02, p = 0.044; Std.
## beta = 1.00, 95% CI [0.03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.51, 95% CI [-1.25, 10.27], t(2038) = 1.54, p = 0.125; Std.
## beta = 0.48, 95% CI [-0.13, 1.10])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-7.01, 4.07], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.75, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.91, 95% CI [-5.59, 1.77], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.21, 95% CI [-0.60, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.14, 95% CI [-49.56, -8.73], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.13, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-6.23, 11.67], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.29, 95% CI [-0.67, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-9.15, 16.89], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.42, 95% CI [-0.98, 1.82])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.15, 9.08], t(2038) = -0.43, p = 0.669; Std.
## beta = -0.27, 95% CI [-1.52, 0.98])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.32. The model's intercept, corresponding to site =
## Simmons, is at 45.99 (95% CI [41.42, 50.55], t(2038) = 19.76, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.84, 95% CI [-8.93, -4.76], t(2038) = -6.45, p < .001; Std. beta = -0.49, 95%
## CI [-0.59, -0.39])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.63, 95% CI [-2.83, -0.42], t(2038) = -2.65, p = 0.008; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-28.95, 24.04], t(2038) = -0.18, p = 0.856; Std. beta = -3.51,
## 95% CI [-6.72, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.81, 95% CI [6.52, 45.10], t(2038) = 2.62, p = 0.009; Std. beta = 1.61, 95%
## CI [0.37, 2.84])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-24.63, 11.56], t(2038) = -0.71, p = 0.479; Std. beta = -0.56,
## 95% CI [-1.96, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.13, 95% CI [-28.27, 2.01], t(2038) = -1.70, p = 0.089; Std. beta = -1.21,
## 95% CI [-2.63, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.35, 95% CI [-11.60, 26.31], t(2038) = 0.76, p = 0.447; Std. beta = 0.69,
## 95% CI [-0.65, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.28, 95% CI [-2.97, 11.54], t(2038) = 1.16, p = 0.247; Std. beta = 0.08, 95%
## CI [-0.38, 0.55])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.34, 95% CI [-27.71, 9.04], t(2038) = -1.00, p = 0.319; Std. beta = -0.55,
## 95% CI [-1.79, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.89, 95% CI [13.88, 23.90], t(2038) = 7.39, p < .001; Std. beta = 1.23, 95%
## CI [0.90, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.46, 95% CI [-1.16, 18.09], t(2038) = 1.72, p = 0.085; Std. beta = 0.42, 95%
## CI [-0.21, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.36, 95% CI [-6.59, 1.87], t(2038) = -1.10, p = 0.274; Std. beta = -0.02,
## 95% CI [-0.31, 0.26])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.40, 95% CI [-21.61, -1.19], t(2038) = -2.19, p = 0.029; Std. beta = -0.51,
## 95% CI [-1.35, 0.32])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.32, 95% CI [-2.53, 7.16], t(2038) = 0.94, p = 0.349; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-10.74, 2.41], t(2038) = -1.24, p = 0.214; Std. beta = -0.13,
## 95% CI [-0.56, 0.30])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-8.39, 29.04], t(2038) = 1.08, p = 0.279; Std. beta = -0.59,
## 95% CI [-2.15, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.55, 95% CI [-24.22, 5.13], t(2038) = -1.28, p = 0.202; Std. beta = -0.20,
## 95% CI [-1.14, 0.75])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.67, 95% CI [-27.95, 24.61], t(2038) = -0.12, p = 0.901; Std. beta = -0.11,
## 95% CI [-1.89, 1.66])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-8.57, 16.43], t(2038) = 0.62, p = 0.538; Std. beta = 0.71, 95%
## CI [-0.14, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.79, 95% CI [-29.06, 7.49], t(2038) = -1.16, p = 0.247; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.72, 95% CI [-24.97, 3.52], t(2038) = -1.48, p = 0.140; Std. beta = -0.74,
## 95% CI [-1.67, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-37.89, 20.79], t(2038) = -0.57, p = 0.568; Std. beta = -1.56,
## 95% CI [-4.73, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.15, 95% CI [-48.76, 4.47], t(2038) = -1.63, p = 0.103; Std. beta = -1.75,
## 95% CI [-4.24, 0.75])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.77, 95% CI [-20.24, 2.71], t(2038) = -1.50, p = 0.134; Std. beta = -0.67,
## 95% CI [-1.45, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.73, 95% CI [32.11, 85.35], t(2038) = 4.33, p < .001; Std. beta = 3.97, 95%
## CI [2.17, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.39, 95% CI [-24.22, 13.44], t(2038) = -0.56, p = 0.575; Std. beta = -1.38,
## 95% CI [-3.77, 1.01])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.91, 95% CI [-19.99, 2.17], t(2038) = -1.58, p = 0.115; Std. beta = -0.39,
## 95% CI [-1.19, 0.40])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.09, 95% CI [-14.98, 6.80], t(2038) = -0.74, p = 0.461; Std. beta = -0.13,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.71, 12.88], t(2038) = -0.94, p = 0.346; Std. beta =
## -0.31, 95% CI [-1.88, 1.26])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.40, 95% CI [-20.77, -4.03], t(2038) = -2.91, p = 0.004; Std. beta = -0.36,
## 95% CI [-0.98, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.64, 95% CI [-31.60, -7.67], t(2038) = -3.22, p = 0.001; Std. beta = -1.38,
## 95% CI [-2.49, -0.27])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.58, 11.10], t(2038) = 0.25, p = 0.802; Std. beta = -0.21,
## 95% CI [-0.87, 0.45])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-16.82, 4.82], t(2038) = -1.09, p = 0.277; Std. beta = -0.58,
## 95% CI [-1.31, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-31.88, -1.01], t(2038) = -2.09, p = 0.037; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.65, 95% CI [-27.66, 24.36], t(2038) = -0.12, p = 0.901; Std. beta = -0.30,
## 95% CI [-1.89, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-12.09, 10.50], t(2038) = -0.14, p = 0.890; Std. beta = 0.11,
## 95% CI [-0.60, 0.82])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-9.33, 16.78], t(2038) = 0.56, p = 0.576; Std. beta = 0.16, 95%
## CI [-0.74, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.80, 95% CI [-22.72, 3.12], t(2038) = -1.49, p = 0.137; Std. beta = -0.91,
## 95% CI [-1.87, 0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-15.83, 3.76], t(2038) = -1.21, p = 0.227; Std. beta = -0.29,
## 95% CI [-0.95, 0.37])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.00, 95% CI [-30.31, 0.32], t(2038) = -1.92, p = 0.055; Std. beta = -0.12,
## 95% CI [-1.18, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.66, 95% CI [-6.96, 16.27], t(2038) = 0.79, p = 0.432; Std. beta = 0.75, 95%
## CI [-0.06, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.15, 14.18], t(2038) = 0.23, p = 0.814; Std. beta = -0.04,
## 95% CI [-0.87, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-10.49, 6.76], t(2038) = -0.42, p = 0.672; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-21.80, 30.12], t(2038) = 0.31, p = 0.753; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-15.35, 20.89], t(2038) = 0.30, p = 0.764; Std. beta = 0.45,
## 95% CI [-0.84, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.86, 95% CI [-28.91, 1.19], t(2038) = -1.81, p = 0.071; Std. beta = -0.56,
## 95% CI [-1.87, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.55, 95% CI [-18.04, -1.06], t(2038) = -2.21, p = 0.028; Std. beta = -0.89,
## 95% CI [-1.92, 0.14])
## - The effect of time firstPFT × OM 5yrPreDx is statistically significant and
## positive (beta = 0.72, 95% CI [0.17, 1.26], t(2038) = 2.56, p = 0.010; Std.
## beta = 0.09, 95% CI [0.02, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.48, 95% CI [-70.78, 1.82], t(2038) = -1.86, p = 0.063;
## Std. beta = -3.71, 95% CI [-7.61, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-13.03, 10.18], t(2038) = -0.24, p = 0.810;
## Std. beta = -0.15, 95% CI [-1.40, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-13.47, 11.00], t(2038) = -0.20, p = 0.843;
## Std. beta = -0.13, 95% CI [-1.45, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-18.09, 11.47], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.36, 95% CI [-1.95, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-7.91, 11.85], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.21, 95% CI [-0.85, 1.27])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-4.87, 0.64], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.23, 95% CI [-0.52, 0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-7.33, 9.06], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.09, 95% CI [-0.79, 0.97])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-2.58, 1.61], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.05, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.76, 2.68], t(2038) = -0.72, p = 0.474; Std.
## beta = -0.17, 95% CI [-0.62, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.44, 3.25], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.15, 95% CI [-0.05, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.63, 9.91], t(2038) = 0.71, p = 0.476; Std.
## beta = 0.28, 95% CI [-0.50, 1.07])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.47], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-1.54, 4.71], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.17, 95% CI [-0.17, 0.51])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.33, 95% CI [-29.29, 2.63], t(2038) = -1.64, p = 0.101;
## Std. beta = -1.43, 95% CI [-3.15, 0.28])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.98, 11.23], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.50, 95% CI [-0.21, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.54, 95% CI [-0.93, 10.02], t(2038) = 1.63, p = 0.104; Std.
## beta = 0.49, 95% CI [-0.10, 1.08])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.95, 9.63], t(2038) = 0.46, p = 0.643; Std.
## beta = 0.20, 95% CI [-0.64, 1.04])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-7.84, 7.51], t(2038) = -0.04, p = 0.967; Std.
## beta = -0.02, 95% CI [-0.84, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.11, 95% CI [-56.52, 36.31], t(2038) = -0.43, p = 0.669;
## Std. beta = -1.09, 95% CI [-6.08, 3.90])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-30.29, 25.13], t(2038) = -0.18, p = 0.855;
## Std. beta = -0.28, 95% CI [-3.26, 2.70])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.86, 4.34], t(2038) = -0.29, p = 0.770; Std.
## beta = -0.08, 95% CI [-0.63, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.90, 14.96], t(2038) = -0.81, p = 0.420;
## Std. beta = -1.13, 95% CI [-3.86, 1.61])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.30, 8.60], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.23, 95% CI [-0.46, 0.92])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-5.17, 8.11], t(2038) = 0.43, p = 0.664; Std.
## beta = 0.16, 95% CI [-0.56, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-4.13, 14.35], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.55, 95% CI [-0.44, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.92, 95% CI [-0.51, 10.35], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.53, 95% CI [-0.05, 1.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-11.09, 9.92], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.06, 95% CI [-1.19, 1.07])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.88, 1.78], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.33, 95% CI [-0.85, 0.19])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.82, 95% CI [-7.61, 3.97], t(2038) = -0.62, p = 0.538; Std.
## beta = -0.20, 95% CI [-0.82, 0.43])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.23, 16.00], t(2038) = -0.74, p = 0.462;
## Std. beta = -1.03, 95% CI [-3.79, 1.72])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.96, 95% CI [-11.87, 7.95], t(2038) = -0.39, p = 0.699; Std.
## beta = -0.21, 95% CI [-1.28, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-2.13, 5.49], t(2038) = 0.87, p = 0.387; Std.
## beta = 0.18, 95% CI [-0.23, 0.59])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-7.83, 6.00], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.10, 95% CI [-0.84, 0.65])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-9.85, 4.82], t(2038) = -0.67, p = 0.501; Std.
## beta = -0.27, 95% CI [-1.06, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-3.36, 5.85], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.13, 95% CI [-0.36, 0.63])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.26, 18.28], t(2038) = 2.02, p = 0.044; Std.
## beta = 1.00, 95% CI [0.03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.51, 95% CI [-1.25, 10.27], t(2038) = 1.54, p = 0.125; Std.
## beta = 0.48, 95% CI [-0.13, 1.10])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-7.01, 4.07], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.75, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.91, 95% CI [-5.59, 1.77], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.21, 95% CI [-0.60, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.14, 95% CI [-49.56, -8.73], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.13, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-6.23, 11.67], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.29, 95% CI [-0.67, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-9.15, 16.89], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.42, 95% CI [-0.98, 1.82])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.15, 9.08], t(2038) = -0.43, p = 0.669; Std.
## beta = -0.27, 95% CI [-1.52, 0.98])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to cohort = CARE-PF, is at 45.99 (95% CI [41.42, 50.55], t(2038)
## = 19.76, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.84, 95% CI [-8.93, -4.76], t(2038) = -6.45, p < .001; Std. beta = -0.49, 95%
## CI [-0.59, -0.39])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.63, 95% CI [-2.83, -0.42], t(2038) = -2.65, p = 0.008; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.45, 95% CI [-28.95, 24.04], t(2038) = -0.18, p = 0.856; Std. beta = -3.51,
## 95% CI [-6.72, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.81, 95% CI [6.52, 45.10], t(2038) = 2.62, p = 0.009; Std. beta = 1.61, 95%
## CI [0.37, 2.84])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-24.63, 11.56], t(2038) = -0.71, p = 0.479; Std. beta = -0.56,
## 95% CI [-1.96, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.13, 95% CI [-28.27, 2.01], t(2038) = -1.70, p = 0.089; Std. beta = -1.21,
## 95% CI [-2.63, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.35, 95% CI [-11.60, 26.31], t(2038) = 0.76, p = 0.447; Std. beta = 0.69,
## 95% CI [-0.65, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.28, 95% CI [-2.97, 11.54], t(2038) = 1.16, p = 0.247; Std. beta = 0.08, 95%
## CI [-0.38, 0.55])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.34, 95% CI [-27.71, 9.04], t(2038) = -1.00, p = 0.319; Std. beta = -0.55,
## 95% CI [-1.79, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.89, 95% CI [13.88, 23.90], t(2038) = 7.39, p < .001; Std. beta = 1.23, 95%
## CI [0.90, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.46, 95% CI [-1.16, 18.09], t(2038) = 1.72, p = 0.085; Std. beta = 0.42, 95%
## CI [-0.21, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.36, 95% CI [-6.59, 1.87], t(2038) = -1.10, p = 0.274; Std. beta = -0.02,
## 95% CI [-0.31, 0.26])
## - The effect of site [104] is statistically significant and negative (beta =
## -11.40, 95% CI [-21.61, -1.19], t(2038) = -2.19, p = 0.029; Std. beta = -0.51,
## 95% CI [-1.35, 0.32])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.32, 95% CI [-2.53, 7.16], t(2038) = 0.94, p = 0.349; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.17, 95% CI [-10.74, 2.41], t(2038) = -1.24, p = 0.214; Std. beta = -0.13,
## 95% CI [-0.56, 0.30])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 10.33, 95% CI [-8.39, 29.04], t(2038) = 1.08, p = 0.279; Std. beta = -0.59,
## 95% CI [-2.15, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.55, 95% CI [-24.22, 5.13], t(2038) = -1.28, p = 0.202; Std. beta = -0.20,
## 95% CI [-1.14, 0.75])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.67, 95% CI [-27.95, 24.61], t(2038) = -0.12, p = 0.901; Std. beta = -0.11,
## 95% CI [-1.89, 1.66])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-8.57, 16.43], t(2038) = 0.62, p = 0.538; Std. beta = 0.71, 95%
## CI [-0.14, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.79, 95% CI [-29.06, 7.49], t(2038) = -1.16, p = 0.247; Std. beta = -0.55,
## 95% CI [-1.80, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.72, 95% CI [-24.97, 3.52], t(2038) = -1.48, p = 0.140; Std. beta = -0.74,
## 95% CI [-1.67, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-37.89, 20.79], t(2038) = -0.57, p = 0.568; Std. beta = -1.56,
## 95% CI [-4.73, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.15, 95% CI [-48.76, 4.47], t(2038) = -1.63, p = 0.103; Std. beta = -1.75,
## 95% CI [-4.24, 0.75])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.77, 95% CI [-20.24, 2.71], t(2038) = -1.50, p = 0.134; Std. beta = -0.67,
## 95% CI [-1.45, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.73, 95% CI [32.11, 85.35], t(2038) = 4.33, p < .001; Std. beta = 3.97, 95%
## CI [2.17, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.39, 95% CI [-24.22, 13.44], t(2038) = -0.56, p = 0.575; Std. beta = -1.38,
## 95% CI [-3.77, 1.01])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.91, 95% CI [-19.99, 2.17], t(2038) = -1.58, p = 0.115; Std. beta = -0.39,
## 95% CI [-1.19, 0.40])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.09, 95% CI [-14.98, 6.80], t(2038) = -0.74, p = 0.461; Std. beta = -0.13,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.71, 12.88], t(2038) = -0.94, p = 0.346; Std. beta =
## -0.31, 95% CI [-1.88, 1.26])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.40, 95% CI [-20.77, -4.03], t(2038) = -2.91, p = 0.004; Std. beta = -0.36,
## 95% CI [-0.98, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.64, 95% CI [-31.60, -7.67], t(2038) = -3.22, p = 0.001; Std. beta = -1.38,
## 95% CI [-2.49, -0.27])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-8.58, 11.10], t(2038) = 0.25, p = 0.802; Std. beta = -0.21,
## 95% CI [-0.87, 0.45])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-16.82, 4.82], t(2038) = -1.09, p = 0.277; Std. beta = -0.58,
## 95% CI [-1.31, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.44, 95% CI [-31.88, -1.01], t(2038) = -2.09, p = 0.037; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.65, 95% CI [-27.66, 24.36], t(2038) = -0.12, p = 0.901; Std. beta = -0.30,
## 95% CI [-1.89, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-12.09, 10.50], t(2038) = -0.14, p = 0.890; Std. beta = 0.11,
## 95% CI [-0.60, 0.82])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.73, 95% CI [-9.33, 16.78], t(2038) = 0.56, p = 0.576; Std. beta = 0.16, 95%
## CI [-0.74, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.80, 95% CI [-22.72, 3.12], t(2038) = -1.49, p = 0.137; Std. beta = -0.91,
## 95% CI [-1.87, 0.06])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-15.83, 3.76], t(2038) = -1.21, p = 0.227; Std. beta = -0.29,
## 95% CI [-0.95, 0.37])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.00, 95% CI [-30.31, 0.32], t(2038) = -1.92, p = 0.055; Std. beta = -0.12,
## 95% CI [-1.18, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.66, 95% CI [-6.96, 16.27], t(2038) = 0.79, p = 0.432; Std. beta = 0.75, 95%
## CI [-0.06, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.15, 14.18], t(2038) = 0.23, p = 0.814; Std. beta = -0.04,
## 95% CI [-0.87, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.86, 95% CI [-10.49, 6.76], t(2038) = -0.42, p = 0.672; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.16, 95% CI [-21.80, 30.12], t(2038) = 0.31, p = 0.753; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.77, 95% CI [-15.35, 20.89], t(2038) = 0.30, p = 0.764; Std. beta = 0.45,
## 95% CI [-0.84, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.86, 95% CI [-28.91, 1.19], t(2038) = -1.81, p = 0.071; Std. beta = -0.56,
## 95% CI [-1.87, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.55, 95% CI [-18.04, -1.06], t(2038) = -2.21, p = 0.028; Std. beta = -0.89,
## 95% CI [-1.92, 0.14])
## - The effect of time firstPFT × OM 5yrPreDx is statistically significant and
## positive (beta = 0.72, 95% CI [0.17, 1.26], t(2038) = 2.56, p = 0.010; Std.
## beta = 0.09, 95% CI [0.02, 0.15])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.48, 95% CI [-70.78, 1.82], t(2038) = -1.86, p = 0.063;
## Std. beta = -3.71, 95% CI [-7.61, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-13.03, 10.18], t(2038) = -0.24, p = 0.810;
## Std. beta = -0.15, 95% CI [-1.40, 1.09])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-13.47, 11.00], t(2038) = -0.20, p = 0.843;
## Std. beta = -0.13, 95% CI [-1.45, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-18.09, 11.47], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.36, 95% CI [-1.95, 1.23])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-7.91, 11.85], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.21, 95% CI [-0.85, 1.27])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-4.87, 0.64], t(2038) = -1.50, p = 0.133; Std.
## beta = -0.23, 95% CI [-0.52, 0.07])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.87, 95% CI [-7.33, 9.06], t(2038) = 0.21, p = 0.836; Std.
## beta = 0.09, 95% CI [-0.79, 0.97])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-2.58, 1.61], t(2038) = -0.46, p = 0.647; Std.
## beta = -0.05, 95% CI [-0.28, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.76, 2.68], t(2038) = -0.72, p = 0.474; Std.
## beta = -0.17, 95% CI [-0.62, 0.29])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.44, 3.25], t(2038) = 1.49, p = 0.136; Std.
## beta = 0.15, 95% CI [-0.05, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.63, 9.91], t(2038) = 0.71, p = 0.476; Std.
## beta = 0.28, 95% CI [-0.50, 1.07])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-2.70, 1.47], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.07, 95% CI [-0.29, 0.16])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.58, 95% CI [-1.54, 4.71], t(2038) = 0.99, p = 0.321; Std.
## beta = 0.17, 95% CI [-0.17, 0.51])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.33, 95% CI [-29.29, 2.63], t(2038) = -1.64, p = 0.101;
## Std. beta = -1.43, 95% CI [-3.15, 0.28])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.98, 11.23], t(2038) = 1.37, p = 0.170; Std.
## beta = 0.50, 95% CI [-0.21, 1.21])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.54, 95% CI [-0.93, 10.02], t(2038) = 1.63, p = 0.104; Std.
## beta = 0.49, 95% CI [-0.10, 1.08])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.95, 9.63], t(2038) = 0.46, p = 0.643; Std.
## beta = 0.20, 95% CI [-0.64, 1.04])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.16, 95% CI [-7.84, 7.51], t(2038) = -0.04, p = 0.967; Std.
## beta = -0.02, 95% CI [-0.84, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.11, 95% CI [-56.52, 36.31], t(2038) = -0.43, p = 0.669;
## Std. beta = -1.09, 95% CI [-6.08, 3.90])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-30.29, 25.13], t(2038) = -0.18, p = 0.855;
## Std. beta = -0.28, 95% CI [-3.26, 2.70])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.86, 4.34], t(2038) = -0.29, p = 0.770; Std.
## beta = -0.08, 95% CI [-0.63, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.90, 14.96], t(2038) = -0.81, p = 0.420;
## Std. beta = -1.13, 95% CI [-3.86, 1.61])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-4.30, 8.60], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.23, 95% CI [-0.46, 0.92])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.47, 95% CI [-5.17, 8.11], t(2038) = 0.43, p = 0.664; Std.
## beta = 0.16, 95% CI [-0.56, 0.87])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-4.13, 14.35], t(2038) = 1.08, p = 0.278; Std.
## beta = 0.55, 95% CI [-0.44, 1.54])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.92, 95% CI [-0.51, 10.35], t(2038) = 1.78, p = 0.076; Std.
## beta = 0.53, 95% CI [-0.05, 1.11])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-11.09, 9.92], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.06, 95% CI [-1.19, 1.07])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-7.88, 1.78], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.33, 95% CI [-0.85, 0.19])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.82, 95% CI [-7.61, 3.97], t(2038) = -0.62, p = 0.538; Std.
## beta = -0.20, 95% CI [-0.82, 0.43])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.23, 16.00], t(2038) = -0.74, p = 0.462;
## Std. beta = -1.03, 95% CI [-3.79, 1.72])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.96, 95% CI [-11.87, 7.95], t(2038) = -0.39, p = 0.699; Std.
## beta = -0.21, 95% CI [-1.28, 0.86])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.68, 95% CI [-2.13, 5.49], t(2038) = 0.87, p = 0.387; Std.
## beta = 0.18, 95% CI [-0.23, 0.59])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.92, 95% CI [-7.83, 6.00], t(2038) = -0.26, p = 0.795; Std.
## beta = -0.10, 95% CI [-0.84, 0.65])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-9.85, 4.82], t(2038) = -0.67, p = 0.501; Std.
## beta = -0.27, 95% CI [-1.06, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-3.36, 5.85], t(2038) = 0.53, p = 0.596; Std.
## beta = 0.13, 95% CI [-0.36, 0.63])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.26, 18.28], t(2038) = 2.02, p = 0.044; Std.
## beta = 1.00, 95% CI [0.03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.51, 95% CI [-1.25, 10.27], t(2038) = 1.54, p = 0.125; Std.
## beta = 0.48, 95% CI [-0.13, 1.10])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-7.01, 4.07], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.16, 95% CI [-0.75, 0.44])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.91, 95% CI [-5.59, 1.77], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.21, 95% CI [-0.60, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.14, 95% CI [-49.56, -8.73], t(2038) = -2.80, p = 0.005;
## Std. beta = -3.13, 95% CI [-5.33, -0.94])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.72, 95% CI [-6.23, 11.67], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.29, 95% CI [-0.67, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.87, 95% CI [-9.15, 16.89], t(2038) = 0.58, p = 0.560; Std.
## beta = 0.42, 95% CI [-0.98, 1.82])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-14.15, 9.08], t(2038) = -0.43, p = 0.669; Std.
## beta = -0.27, 95% CI [-1.52, 0.98])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*OM_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14681.2
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1283 -0.4898 -0.0099 0.4343 7.1002
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 137.56 11.729
## time_firstPFT 10.96 3.311 -0.27
## Residual 41.72 6.459
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 41.80509 5.24038 7.977
## time_firstPFT -4.79596 2.37086 -2.023
## OM_5yrPreDx -1.27599 0.63009 -2.025
## disadv -4.92098 2.33935 -2.104
## dich_RaceNon-White -2.58414 2.28590 -1.130
## sexF -2.30271 1.42077 -1.621
## age_dx 0.13835 0.07406 1.868
## smokeHxFormer -2.83413 1.40766 -2.013
## smokeHxAlways 8.11180 7.06636 1.148
## smokeHxUnknown -2.86282 3.17132 -0.903
## site02R -5.85348 13.43586 -0.436
## site03R 21.47299 9.85743 2.178
## site04R -5.89524 9.14565 -0.645
## site05R -13.44526 7.68796 -1.749
## site06R -5.96498 13.48151 -0.442
## site07R 2.81887 3.69999 0.762
## site09R -11.21323 9.31720 -1.203
## site101 19.23536 2.58237 7.449
## site102 7.59608 4.92919 1.541
## site103 -2.14670 2.26625 -0.947
## site104 -10.07232 5.21000 -1.933
## site105 2.71311 2.49807 1.086
## site106 -5.97124 3.40175 -1.755
## site107 8.07137 9.48932 0.851
## site108 -4.41708 7.79534 -0.567
## site10R -0.58285 13.40472 -0.043
## site11R 2.47121 6.34277 0.390
## site12R -9.06664 9.24446 -0.981
## site13R -12.07851 7.24422 -1.667
## site14R -9.91045 14.92379 -0.664
## site15R -19.17255 13.49766 -1.420
## site16R -8.42544 5.89417 -1.429
## site17R 63.19925 13.58071 4.654
## site18R -3.88978 9.55966 -0.407
## site19R -9.01727 5.65512 -1.595
## site20R -4.09505 5.52389 -0.741
## site21R -11.75294 12.50985 -0.939
## site22R -14.63705 4.30605 -3.399
## site23R -25.99591 7.66602 -3.391
## site24R 1.01283 4.98241 0.203
## site25R -8.46488 5.54386 -1.527
## site28R -15.33333 7.85289 -1.953
## site29R -4.48465 13.17767 -0.340
## site31R -1.18272 5.77159 -0.205
## site32R 4.11269 6.65398 0.618
## site33R -10.09256 6.56637 -1.537
## site34R -5.82607 4.96482 -1.173
## site35R -15.35275 7.78105 -1.973
## site36R 3.92585 5.90022 0.665
## site37R -0.24166 6.49804 -0.037
## site38R -1.29591 4.37470 -0.296
## site39R 11.94636 13.37782 0.893
## site40R 0.97058 9.18245 0.106
## site41R -14.66411 7.67227 -1.911
## site42R -11.15334 4.34488 -2.567
## time_firstPFT:OM_5yrPreDx 0.57540 0.29780 1.932
## time_firstPFT:disadv 0.92678 1.12893 0.821
## time_firstPFT:dich_RaceNon-White -0.68295 1.10669 -0.617
## time_firstPFT:sexF 0.47878 0.66479 0.720
## time_firstPFT:age_dx -0.03428 0.03446 -0.995
## time_firstPFT:smokeHxFormer -0.59924 0.67277 -0.891
## time_firstPFT:smokeHxAlways -5.54180 6.04991 -0.916
## time_firstPFT:smokeHxUnknown 2.11779 1.66484 1.272
## time_firstPFT:site02R -33.16300 18.53136 -1.790
## time_firstPFT:site03R -1.06202 5.97183 -0.178
## time_firstPFT:site04R -1.93273 6.28866 -0.307
## time_firstPFT:site05R -3.11154 7.56078 -0.412
## time_firstPFT:site07R -1.72931 1.45510 -1.188
## time_firstPFT:site09R 1.80695 4.23476 0.427
## time_firstPFT:site101 -0.35216 1.10090 -0.320
## time_firstPFT:site102 -1.03295 2.19913 -0.470
## time_firstPFT:site103 1.78739 1.00920 1.771
## time_firstPFT:site104 2.41790 3.78041 0.640
## time_firstPFT:site105 -0.40440 1.09331 -0.370
## time_firstPFT:site106 2.06680 1.64703 1.255
## time_firstPFT:site107 -12.63465 8.15870 -1.549
## time_firstPFT:site108 5.36340 3.58002 1.498
## time_firstPFT:site11R 5.25796 2.86885 1.833
## time_firstPFT:site12R 2.21029 4.02250 0.549
## time_firstPFT:site13R -0.20959 3.96721 -0.053
## time_firstPFT:site14R -9.32398 23.68145 -0.394
## time_firstPFT:site15R -2.50699 14.15136 -0.177
## time_firstPFT:site16R -0.90876 2.67591 -0.340
## time_firstPFT:site18R -10.28779 12.98406 -0.792
## time_firstPFT:site19R 2.17414 3.35398 0.648
## time_firstPFT:site20R 1.13290 3.43820 0.330
## time_firstPFT:site21R 5.72229 4.74852 1.205
## time_firstPFT:site22R 5.89121 2.82320 2.087
## time_firstPFT:site23R 24.30166 26.72571 0.909
## time_firstPFT:site24R -2.79749 2.48613 -1.125
## time_firstPFT:site25R -0.99559 3.01700 -0.330
## time_firstPFT:site28R -8.41005 13.14292 -0.640
## time_firstPFT:site29R -0.85533 5.11097 -0.167
## time_firstPFT:site31R 2.27322 2.00167 1.136
## time_firstPFT:site32R -0.38879 3.58143 -0.109
## time_firstPFT:site33R -2.98882 3.83851 -0.779
## time_firstPFT:site34R 1.43821 2.41189 0.596
## time_firstPFT:site35R 9.95999 4.65757 2.138
## time_firstPFT:site36R 4.71789 2.97589 1.585
## time_firstPFT:site37R -1.06280 2.94347 -0.361
## time_firstPFT:site38R -1.79989 1.90108 -0.947
## time_firstPFT:site39R -29.07067 10.50444 -2.767
## time_firstPFT:site40R 2.38418 4.66183 0.511
## time_firstPFT:site41R 4.69676 6.67116 0.704
## time_firstPFT:site42R -3.05301 5.94521 -0.514##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.791
## Unadjusted ICC: 0.527report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## OM_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to time_firstPFT = 0, is at 41.81 (95% CI [31.53, 52.08], t(2008)
## = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## OM_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to OM_5yrPreDx =
## 0, is at 41.81 (95% CI [31.53, 52.08], t(2008) = 7.98, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to disadv = 0, is at 41.81 (95% CI [31.53,
## 52.08], t(2008) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to dich_Race = White, is at 41.81 (95% CI
## [31.53, 52.08], t(2008) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to sex = M, is at 41.81 (95% CI [31.53,
## 52.08], t(2008) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to age_dx = 0, is at 41.81 (95% CI [31.53,
## 52.08], t(2008) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to smokeHx = Never, is at 41.81 (95% CI
## [31.53, 52.08], t(2008) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to site = Simmons, is at 41.81 (95% CI [31.53,
## 52.08], t(2008) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to cohort =
## CARE-PF, is at 41.81 (95% CI [31.53, 52.08], t(2008) = 7.98, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.80, 95% CI [-9.45, -0.15], t(2008) = -2.02, p = 0.043; Std. beta = -0.49,
## 95% CI [-0.65, -0.33])
## - The effect of OM 5yrPreDx is statistically significant and negative (beta =
## -1.28, 95% CI [-2.51, -0.04], t(2008) = -2.03, p = 0.043; Std. beta = -0.03,
## 95% CI [-0.13, 0.06])
## - The effect of disadv is statistically significant and negative (beta = -4.92,
## 95% CI [-9.51, -0.33], t(2008) = -2.10, p = 0.036; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.58, 95% CI [-7.07, 1.90], t(2008) = -1.13, p = 0.258; Std.
## beta = -0.24, 95% CI [-0.55, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.30, 95% CI [-5.09, 0.48], t(2008) = -1.62, p = 0.105; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.90e-03, 0.28], t(2008) = 1.87, p = 0.062; Std. beta = 0.05,
## 95% CI [-0.04, 0.15])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.83, 95% CI [-5.59, -0.07], t(2008) = -2.01, p = 0.044; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.11, 95% CI [-5.75, 21.97], t(2008) = 1.15, p = 0.251; Std. beta =
## 8.93e-03, 95% CI [-1.20, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.86, 95% CI [-9.08, 3.36], t(2008) = -0.90, p = 0.367; Std. beta =
## 0.01, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-32.20, 20.50], t(2008) = -0.44, p = 0.663; Std. beta = -3.62,
## 95% CI [-6.84, -0.40])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.47, 95% CI [2.14, 40.80], t(2008) = 2.18, p = 0.029; Std. beta = 1.35, 95%
## CI [0.10, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-23.83, 12.04], t(2008) = -0.64, p = 0.519; Std. beta = -0.59,
## 95% CI [-1.99, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.45, 95% CI [-28.52, 1.63], t(2008) = -1.75, p = 0.080; Std. beta = -1.21,
## 95% CI [-2.64, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.96, 95% CI [-32.40, 20.47], t(2008) = -0.44, p = 0.658; Std. beta = -0.40,
## 95% CI [-2.19, 1.38])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.82, 95% CI [-4.44, 10.08], t(2008) = 0.76, p = 0.446; Std. beta = 0.02, 95%
## CI [-0.45, 0.49])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-29.49, 7.06], t(2008) = -1.20, p = 0.229; Std. beta = -0.58,
## 95% CI [-1.83, 0.67])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.24, 95% CI [14.17, 24.30], t(2008) = 7.45, p < .001; Std. beta = 1.26, 95%
## CI [0.92, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.60, 95% CI [-2.07, 17.26], t(2008) = 1.54, p = 0.123; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.15, 95% CI [-6.59, 2.30], t(2008) = -0.95, p = 0.344; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.07, 95% CI [-20.29, 0.15], t(2008) = -1.93, p = 0.053; Std. beta = -0.45,
## 95% CI [-1.29, 0.40])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.71, 95% CI [-2.19, 7.61], t(2008) = 1.09, p = 0.278; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.97, 95% CI [-12.64, 0.70], t(2008) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.64, 0.24])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.07, 95% CI [-10.54, 26.68], t(2008) = 0.85, p = 0.395; Std. beta = -0.68,
## 95% CI [-2.25, 0.88])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-19.70, 10.87], t(2008) = -0.57, p = 0.571; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.58, 95% CI [-26.87, 25.71], t(2008) = -0.04, p = 0.965; Std. beta = -0.04,
## 95% CI [-1.81, 1.74])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-9.97, 14.91], t(2008) = 0.39, p = 0.697; Std. beta = 0.68, 95%
## CI [-0.17, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-27.20, 9.06], t(2008) = -0.98, p = 0.327; Std. beta = -0.40,
## 95% CI [-1.65, 0.85])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.08, 95% CI [-26.29, 2.13], t(2008) = -1.67, p = 0.096; Std. beta = -0.84,
## 95% CI [-1.78, 0.10])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.91, 95% CI [-39.18, 19.36], t(2008) = -0.66, p = 0.507; Std. beta = -1.58,
## 95% CI [-4.76, 1.61])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.17, 95% CI [-45.64, 7.30], t(2008) = -1.42, p = 0.156; Std. beta = -1.54,
## 95% CI [-4.04, 0.97])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.43, 95% CI [-19.98, 3.13], t(2008) = -1.43, p = 0.153; Std. beta = -0.66,
## 95% CI [-1.46, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.20, 95% CI [36.57, 89.83], t(2008) = 4.65, p < .001; Std. beta = 4.27, 95%
## CI [2.47, 6.07])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-22.64, 14.86], t(2008) = -0.41, p = 0.684; Std. beta = -1.26,
## 95% CI [-3.66, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.02, 95% CI [-20.11, 2.07], t(2008) = -1.59, p = 0.111; Std. beta = -0.40,
## 95% CI [-1.20, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.10, 95% CI [-14.93, 6.74], t(2008) = -0.74, p = 0.459; Std. beta = -0.17,
## 95% CI [-0.96, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.75, 95% CI [-36.29, 12.78], t(2008) = -0.94, p = 0.348; Std. beta =
## -0.24, 95% CI [-1.80, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.64, 95% CI [-23.08, -6.19], t(2008) = -3.40, p < .001; Std. beta = -0.42,
## 95% CI [-1.04, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -26.00, 95% CI [-41.03, -10.96], t(2008) = -3.39, p < .001; Std. beta = 0.61,
## 95% CI [-4.08, 5.29])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.01, 95% CI [-8.76, 10.78], t(2008) = 0.20, p = 0.839; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.46, 95% CI [-19.34, 2.41], t(2008) = -1.53, p = 0.127; Std. beta = -0.67,
## 95% CI [-1.41, 0.08])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.33, 95% CI [-30.73, 0.07], t(2008) = -1.95, p = 0.051; Std. beta = -1.85,
## 95% CI [-4.31, 0.60])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.48, 95% CI [-30.33, 21.36], t(2008) = -0.34, p = 0.734; Std. beta = -0.39,
## 95% CI [-1.98, 1.21])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.18, 95% CI [-12.50, 10.14], t(2008) = -0.20, p = 0.838; Std. beta = 0.14,
## 95% CI [-0.58, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 4.11, 95% CI [-8.94, 17.16], t(2008) = 0.62, p = 0.537; Std. beta = 0.24, 95%
## CI [-0.67, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-22.97, 2.79], t(2008) = -1.54, p = 0.124; Std. beta = -0.97,
## 95% CI [-1.95, 1.22e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.83, 95% CI [-15.56, 3.91], t(2008) = -1.17, p = 0.241; Std. beta = -0.25,
## 95% CI [-0.92, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.35, 95% CI [-30.61, -0.09], t(2008) = -1.97, p = 0.049; Std. beta = -0.07,
## 95% CI [-1.14, 1.01])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.93, 95% CI [-7.65, 15.50], t(2008) = 0.67, p = 0.506; Std. beta = 0.72, 95%
## CI [-0.09, 1.54])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-12.99, 12.50], t(2008) = -0.04, p = 0.970; Std. beta = -0.12,
## 95% CI [-0.96, 0.72])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.30, 95% CI [-9.88, 7.28], t(2008) = -0.30, p = 0.767; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 11.95, 95% CI [-14.29, 38.18], t(2008) = 0.89, p = 0.372; Std. beta = -2.02,
## 95% CI [-4.13, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.97, 95% CI [-17.04, 18.98], t(2008) = 0.11, p = 0.916; Std. beta = 0.30,
## 95% CI [-1.00, 1.60])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.66, 95% CI [-29.71, 0.38], t(2008) = -1.91, p = 0.056; Std. beta = -0.53,
## 95% CI [-1.85, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.15, 95% CI [-19.67, -2.63], t(2008) = -2.57, p = 0.010; Std. beta = -1.05,
## 95% CI [-2.09, -0.01])
## - The effect of time firstPFT × OM 5yrPreDx is statistically non-significant
## and positive (beta = 0.58, 95% CI [-8.64e-03, 1.16], t(2008) = 1.93, p = 0.053;
## Std. beta = 0.07, 95% CI [-1.03e-03, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 0.93, 95% CI [-1.29, 3.14], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.03, 95% CI [-0.04, 0.10])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.85, 1.49], t(2008) =
## -0.62, p = 0.537; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.48, 95% CI [-0.82, 1.78], t(2008) = 0.72, p = 0.471; Std.
## beta = 0.05, 95% CI [-0.09, 0.19])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.03], t(2008) = -0.99, p = 0.320; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.60, 95% CI [-1.92, 0.72], t(2008) =
## -0.89, p = 0.373; Std. beta = -0.06, 95% CI [-0.21, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.41, 6.32], t(2008) =
## -0.92, p = 0.360; Std. beta = -0.60, 95% CI [-1.87, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.12, 95% CI [-1.15, 5.38], t(2008) =
## 1.27, p = 0.203; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.16, 95% CI [-69.51, 3.18], t(2008) = -1.79, p = 0.074;
## Std. beta = -3.57, 95% CI [-7.48, 0.34])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-12.77, 10.65], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.11, 95% CI [-1.38, 1.15])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-14.27, 10.40], t(2008) = -0.31, p = 0.759;
## Std. beta = -0.21, 95% CI [-1.54, 1.12])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-17.94, 11.72], t(2008) = -0.41, p = 0.681;
## Std. beta = -0.33, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.73, 95% CI [-4.58, 1.12], t(2008) = -1.19, p = 0.235; Std.
## beta = -0.19, 95% CI [-0.49, 0.12])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.50, 10.11], t(2008) = 0.43, p = 0.670; Std.
## beta = 0.19, 95% CI [-0.70, 1.09])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.35, 95% CI [-2.51, 1.81], t(2008) = -0.32, p = 0.749; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.03, 95% CI [-5.35, 3.28], t(2008) = -0.47, p = 0.639; Std.
## beta = -0.11, 95% CI [-0.58, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.79, 95% CI [-0.19, 3.77], t(2008) = 1.77, p = 0.077; Std.
## beta = 0.19, 95% CI [-0.02, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-5.00, 9.83], t(2008) = 0.64, p = 0.523; Std.
## beta = 0.26, 95% CI [-0.54, 1.06])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-2.55, 1.74], t(2008) = -0.37, p = 0.712; Std.
## beta = -0.04, 95% CI [-0.27, 0.19])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.16, 5.30], t(2008) = 1.25, p = 0.210; Std.
## beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.63, 95% CI [-28.64, 3.37], t(2008) = -1.55, p = 0.122;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-1.66, 12.38], t(2008) = 1.50, p = 0.134; Std.
## beta = 0.58, 95% CI [-0.18, 1.33])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.26, 95% CI [-0.37, 10.88], t(2008) = 1.83, p = 0.067; Std.
## beta = 0.57, 95% CI [-0.04, 1.17])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-5.68, 10.10], t(2008) = 0.55, p = 0.583; Std.
## beta = 0.24, 95% CI [-0.61, 1.09])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-7.99, 7.57], t(2008) = -0.05, p = 0.958; Std.
## beta = -0.02, 95% CI [-0.86, 0.81])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-55.77, 37.12], t(2008) = -0.39, p = 0.694;
## Std. beta = -1.00, 95% CI [-6.00, 4.00])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-30.26, 25.25], t(2008) = -0.18, p = 0.859;
## Std. beta = -0.27, 95% CI [-3.26, 2.72])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.91, 95% CI [-6.16, 4.34], t(2008) = -0.34, p = 0.734; Std.
## beta = -0.10, 95% CI [-0.66, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-35.75, 15.18], t(2008) = -0.79, p = 0.428;
## Std. beta = -1.11, 95% CI [-3.85, 1.63])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.17, 95% CI [-4.40, 8.75], t(2008) = 0.65, p = 0.517; Std.
## beta = 0.23, 95% CI [-0.47, 0.94])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.13, 95% CI [-5.61, 7.88], t(2008) = 0.33, p = 0.742; Std.
## beta = 0.12, 95% CI [-0.60, 0.85])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.72, 95% CI [-3.59, 15.03], t(2008) = 1.21, p = 0.228; Std.
## beta = 0.62, 95% CI [-0.39, 1.62])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.89, 95% CI [0.35, 11.43], t(2008) = 2.09, p = 0.037; Std.
## beta = 0.63, 95% CI [0.04, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.30, 95% CI [-28.11, 76.71], t(2008) = 0.91, p = 0.363; Std.
## beta = 2.62, 95% CI [-3.03, 8.26])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-7.67, 2.08], t(2008) = -1.13, p = 0.261; Std.
## beta = -0.30, 95% CI [-0.83, 0.22])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-6.91, 4.92], t(2008) = -0.33, p = 0.741; Std.
## beta = -0.11, 95% CI [-0.74, 0.53])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.41, 95% CI [-34.19, 17.37], t(2008) = -0.64, p = 0.522;
## Std. beta = -0.91, 95% CI [-3.68, 1.87])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-10.88, 9.17], t(2008) = -0.17, p = 0.867; Std.
## beta = -0.09, 95% CI [-1.17, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-1.65, 6.20], t(2008) = 1.14, p = 0.256; Std.
## beta = 0.24, 95% CI [-0.18, 0.67])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-7.41, 6.63], t(2008) = -0.11, p = 0.914; Std.
## beta = -0.04, 95% CI [-0.80, 0.71])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.99, 95% CI [-10.52, 4.54], t(2008) = -0.78, p = 0.436; Std.
## beta = -0.32, 95% CI [-1.13, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-3.29, 6.17], t(2008) = 0.60, p = 0.551; Std.
## beta = 0.15, 95% CI [-0.35, 0.66])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.96, 95% CI [0.83, 19.09], t(2008) = 2.14, p = 0.033; Std.
## beta = 1.07, 95% CI [0.09, 2.06])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.72, 95% CI [-1.12, 10.55], t(2008) = 1.59, p = 0.113; Std.
## beta = 0.51, 95% CI [-0.12, 1.14])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.84, 4.71], t(2008) = -0.36, p = 0.718; Std.
## beta = -0.11, 95% CI [-0.74, 0.51])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.80, 95% CI [-5.53, 1.93], t(2008) = -0.95, p = 0.344; Std.
## beta = -0.19, 95% CI [-0.60, 0.21])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.07, 95% CI [-49.67, -8.47], t(2008) = -2.77, p = 0.006;
## Std. beta = -3.13, 95% CI [-5.35, -0.91])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.76, 11.53], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.26, 95% CI [-0.73, 1.24])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-8.39, 17.78], t(2008) = 0.70, p = 0.481; Std.
## beta = 0.51, 95% CI [-0.90, 1.91])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.05, 95% CI [-14.71, 8.61], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*SS_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14846.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1310 -0.4953 -0.0038 0.4388 7.1030
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 142.70 11.946
## time_firstPFT 11.02 3.320 -0.30
## Residual 41.75 6.462
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 42.8287 1.5546 27.549
## time_firstPFT -5.1858 0.7280 -7.124
## SS_5yrPreDx -10.8880 5.3382 -2.040
## site02R 21.9877 17.9294 1.226
## site03R 24.7144 9.8793 2.502
## site04R -5.4151 9.2518 -0.585
## site05R -13.8802 7.7758 -1.785
## site06R 4.3569 9.6613 0.451
## site07R 5.4043 3.6799 1.469
## site09R -6.3883 9.4446 -0.676
## site101 20.0708 2.5105 7.995
## site102 7.6329 4.9731 1.535
## site103 -0.6860 2.1981 -0.312
## site104 -9.1116 5.1539 -1.768
## site105 1.7360 2.4777 0.701
## site106 -3.4959 3.3575 -1.041
## site107 11.0077 9.5773 1.149
## site108 -9.4972 7.5405 -1.259
## site10R 3.0739 14.2979 0.215
## site11R 3.7353 6.4026 0.583
## site12R -9.9949 9.3440 -1.070
## site13R -9.9311 7.2873 -1.363
## site14R -5.2883 14.9724 -0.353
## site15R -23.3347 13.6164 -1.714
## site16R -5.7659 5.9828 -0.964
## site17R 58.6854 13.6271 4.307
## site18R -1.2760 9.7689 -0.131
## site19R -6.2125 5.5375 -1.122
## site20R -3.7014 5.5723 -0.664
## site21R -12.4451 12.6934 -0.980
## site22R -9.7605 4.2778 -2.282
## site23R -16.4339 6.1928 -2.654
## site24R 1.7778 5.0269 0.354
## site25R 8.3659 8.8652 0.944
## site28R -17.5396 7.9014 -2.220
## site29R 4.3324 13.3866 0.324
## site31R 0.2006 5.7671 0.035
## site32R 5.8660 6.6446 0.883
## site33R -4.0758 6.8903 -0.592
## site34R -4.7727 4.9800 -0.958
## site35R -12.9252 7.8080 -1.655
## site36R 3.2795 5.9453 0.552
## site37R 2.0658 6.4782 0.319
## site38R -1.5942 4.4147 -0.361
## site39R 5.1277 13.2772 0.386
## site40R 3.0245 9.2890 0.326
## site41R -11.6736 7.7295 -1.510
## site42R -7.7158 4.3388 -1.778
## time_firstPFT:SS_5yrPreDx 3.7221 2.6024 1.430
## time_firstPFT:site02R -42.9200 19.3927 -2.213
## time_firstPFT:site03R -0.9911 5.9325 -0.167
## time_firstPFT:site04R -1.7625 6.2484 -0.282
## time_firstPFT:site05R -3.1553 7.5525 -0.418
## time_firstPFT:site06R 3.2952 5.0341 0.655
## time_firstPFT:site07R -2.6494 1.3983 -1.895
## time_firstPFT:site09R 0.1752 4.2235 0.041
## time_firstPFT:site101 -0.9621 1.0535 -0.913
## time_firstPFT:site102 -1.1732 2.1849 -0.537
## time_firstPFT:site103 0.8595 0.9782 0.879
## time_firstPFT:site104 2.1992 3.7147 0.592
## time_firstPFT:site105 -0.2297 1.0606 -0.217
## time_firstPFT:site106 1.3104 1.5988 0.820
## time_firstPFT:site107 -13.6231 8.1498 -1.672
## time_firstPFT:site108 4.3461 3.3974 1.279
## time_firstPFT:site11R 4.7047 2.8106 1.674
## time_firstPFT:site12R 1.5614 3.9940 0.391
## time_firstPFT:site13R -0.6441 3.9237 -0.164
## time_firstPFT:site14R -11.5149 23.6774 -0.486
## time_firstPFT:site15R -2.1015 14.1444 -0.149
## time_firstPFT:site16R -1.9025 2.6362 -0.722
## time_firstPFT:site18R -12.0807 12.9903 -0.930
## time_firstPFT:site19R 0.9485 3.2589 0.291
## time_firstPFT:site20R 1.1516 3.3926 0.339
## time_firstPFT:site21R 5.3150 4.7390 1.122
## time_firstPFT:site22R 3.6496 2.8014 1.303
## time_firstPFT:site23R -2.0423 5.4121 -0.377
## time_firstPFT:site24R -3.3214 2.4729 -1.343
## time_firstPFT:site25R -6.8832 4.2464 -1.621
## time_firstPFT:site28R -9.2471 13.0655 -0.708
## time_firstPFT:site29R -4.2872 5.1308 -0.836
## time_firstPFT:site31R 1.2376 1.9484 0.635
## time_firstPFT:site32R -1.6164 3.5465 -0.456
## time_firstPFT:site33R -4.9795 3.9025 -1.276
## time_firstPFT:site34R 0.7996 2.3564 0.339
## time_firstPFT:site35R 8.3549 4.5888 1.821
## time_firstPFT:site36R 5.1011 2.9433 1.733
## time_firstPFT:site37R -1.6008 2.8406 -0.564
## time_firstPFT:site38R -2.0930 1.8846 -1.111
## time_firstPFT:site39R -29.7806 10.4252 -2.857
## time_firstPFT:site40R 1.9168 4.5573 0.421
## time_firstPFT:site41R 3.0090 6.6597 0.452
## time_firstPFT:site42R -3.1442 5.9239 -0.531##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.792
## Unadjusted ICC: 0.542report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SS_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.32. The model's
## intercept, corresponding to time_firstPFT = 0, is at 42.83 (95% CI [39.78,
## 45.88], t(2038) = 27.55, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.19, 95% CI [-6.61, -3.76], t(2038) = -7.12, p < .001; Std. beta = -0.46, 95%
## CI [-0.56, -0.36])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -10.89, 95% CI [-21.36, -0.42], t(2038) = -2.04, p = 0.042; Std. beta = -0.07,
## 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-13.17, 57.15], t(2038) = 1.23, p = 0.220; Std. beta = -2.67,
## 95% CI [-6.24, 0.89])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.71, 95% CI [5.34, 44.09], t(2038) = 2.50, p = 0.012; Std. beta = 1.57, 95%
## CI [0.34, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.42, 95% CI [-23.56, 12.73], t(2038) = -0.59, p = 0.558; Std. beta = -0.54,
## 95% CI [-1.93, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.88, 95% CI [-29.13, 1.37], t(2038) = -1.79, p = 0.074; Std. beta = -1.24,
## 95% CI [-2.67, 0.18])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-14.59, 23.30], t(2038) = 0.45, p = 0.652; Std. beta = 0.61,
## 95% CI [-0.72, 1.95])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-1.81, 12.62], t(2038) = 1.47, p = 0.142; Std. beta = 0.11, 95%
## CI [-0.35, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-24.91, 12.13], t(2038) = -0.68, p = 0.499; Std. beta = -0.41,
## 95% CI [-1.66, 0.83])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.07, 95% CI [15.15, 24.99], t(2038) = 7.99, p < .001; Std. beta = 1.26, 95%
## CI [0.94, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.63, 95% CI [-2.12, 17.39], t(2038) = 1.53, p = 0.125; Std. beta = 0.40, 95%
## CI [-0.23, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.00, 3.62], t(2038) = -0.31, p = 0.755; Std. beta = 0.04,
## 95% CI [-0.25, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.11, 95% CI [-19.22, 1.00], t(2038) = -1.77, p = 0.077; Std. beta = -0.40,
## 95% CI [-1.23, 0.43])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.74, 95% CI [-3.12, 6.60], t(2038) = 0.70, p = 0.484; Std. beta = 0.10, 95%
## CI [-0.22, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-10.08, 3.09], t(2038) = -1.04, p = 0.298; Std. beta = -0.11,
## 95% CI [-0.54, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.01, 95% CI [-7.77, 29.79], t(2038) = 1.15, p = 0.251; Std. beta = -0.58,
## 95% CI [-2.13, 0.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.50, 95% CI [-24.29, 5.29], t(2038) = -1.26, p = 0.208; Std. beta = -0.22,
## 95% CI [-1.17, 0.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.07, 95% CI [-24.97, 31.11], t(2038) = 0.21, p = 0.830; Std. beta = 0.21,
## 95% CI [-1.69, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.82, 16.29], t(2038) = 0.58, p = 0.560; Std. beta = 0.71, 95%
## CI [-0.13, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.99, 95% CI [-28.32, 8.33], t(2038) = -1.07, p = 0.285; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-24.22, 4.36], t(2038) = -1.36, p = 0.173; Std. beta = -0.73,
## 95% CI [-1.66, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.29, 95% CI [-34.65, 24.07], t(2038) = -0.35, p = 0.724; Std. beta = -1.47,
## 95% CI [-4.64, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.33, 95% CI [-50.04, 3.37], t(2038) = -1.71, p = 0.087; Std. beta = -1.78,
## 95% CI [-4.28, 0.71])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.77, 95% CI [-17.50, 5.97], t(2038) = -0.96, p = 0.335; Std. beta = -0.57,
## 95% CI [-1.37, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.96, 85.41], t(2038) = 4.31, p < .001; Std. beta = 3.97, 95%
## CI [2.16, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.28, 95% CI [-20.43, 17.88], t(2038) = -0.13, p = 0.896; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-17.07, 4.65], t(2038) = -1.12, p = 0.262; Std. beta = -0.33,
## 95% CI [-1.11, 0.45])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.63, 7.23], t(2038) = -0.66, p = 0.507; Std. beta = -0.14,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-37.34, 12.45], t(2038) = -0.98, p = 0.327; Std. beta =
## -0.33, 95% CI [-1.89, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.76, 95% CI [-18.15, -1.37], t(2038) = -2.28, p = 0.023; Std. beta = -0.31,
## 95% CI [-0.92, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.43, 95% CI [-28.58, -4.29], t(2038) = -2.65, p = 0.008; Std. beta = -1.31,
## 95% CI [-2.43, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-8.08, 11.64], t(2038) = 0.35, p = 0.724; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 8.37, 95% CI [-9.02, 25.75], t(2038) = 0.94, p = 0.345; Std. beta = -0.10,
## 95% CI [-1.23, 1.03])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.54, 95% CI [-33.04, -2.04], t(2038) = -2.22, p = 0.027; Std. beta = -2.08,
## 95% CI [-4.51, 0.34])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-21.92, 30.59], t(2038) = 0.32, p = 0.746; Std. beta = -0.12,
## 95% CI [-1.72, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-11.11, 11.51], t(2038) = 0.03, p = 0.972; Std. beta = 0.13,
## 95% CI [-0.57, 0.84])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-7.16, 18.90], t(2038) = 0.88, p = 0.377; Std. beta = 0.24, 95%
## CI [-0.66, 1.14])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-17.59, 9.44], t(2038) = -0.59, p = 0.554; Std. beta = -0.76,
## 95% CI [-1.76, 0.24])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-14.54, 4.99], t(2038) = -0.96, p = 0.338; Std. beta = -0.25,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.24, 2.39], t(2038) = -1.66, p = 0.098; Std. beta = -0.06,
## 95% CI [-1.12, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-8.38, 14.94], t(2038) = 0.55, p = 0.581; Std. beta = 0.72, 95%
## CI [-0.09, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.07, 95% CI [-10.64, 14.77], t(2038) = 0.32, p = 0.750; Std. beta = -0.02,
## 95% CI [-0.84, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-10.25, 7.06], t(2038) = -0.36, p = 0.718; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-20.91, 31.17], t(2038) = 0.39, p = 0.699; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-15.19, 21.24], t(2038) = 0.33, p = 0.745; Std. beta = 0.39,
## 95% CI [-0.90, 1.68])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-26.83, 3.48], t(2038) = -1.51, p = 0.131; Std. beta = -0.50,
## 95% CI [-1.80, 0.81])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-16.22, 0.79], t(2038) = -1.78, p = 0.075; Std. beta = -0.83,
## 95% CI [-1.85, 0.20])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.72, 95% CI [-1.38, 8.83], t(2038) = 1.43, p = 0.153;
## Std. beta = 0.08, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -42.92, 95% CI [-80.95, -4.89], t(2038) = -2.21, p = 0.027;
## Std. beta = -4.61, 95% CI [-8.70, -0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-12.63, 10.64], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-14.02, 10.49], t(2038) = -0.28, p = 0.778;
## Std. beta = -0.19, 95% CI [-1.51, 1.13])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-17.97, 11.66], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-6.58, 13.17], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.35, 95% CI [-0.71, 1.42])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-5.39, 0.09], t(2038) = -1.89, p = 0.058; Std.
## beta = -0.28, 95% CI [-0.58, 9.98e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-8.11, 8.46], t(2038) = 0.04, p = 0.967; Std.
## beta = 0.02, 95% CI [-0.87, 0.91])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.03, 1.10], t(2038) = -0.91, p = 0.361; Std.
## beta = -0.10, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-5.46, 3.11], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-1.06, 2.78], t(2038) = 0.88, p = 0.380; Std.
## beta = 0.09, 95% CI [-0.11, 0.30])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-5.09, 9.48], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.24, 95% CI [-0.55, 1.02])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.31, 1.85], t(2038) = -0.22, p = 0.829; Std.
## beta = -0.02, 95% CI [-0.25, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-1.83, 4.45], t(2038) = 0.82, p = 0.413; Std.
## beta = 0.14, 95% CI [-0.20, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.62, 95% CI [-29.61, 2.36], t(2038) = -1.67, p = 0.095;
## Std. beta = -1.46, 95% CI [-3.18, 0.25])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.35, 95% CI [-2.32, 11.01], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.47, 95% CI [-0.25, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-0.81, 10.22], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.51, 95% CI [-0.09, 1.10])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.27, 9.39], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.17, 95% CI [-0.67, 1.01])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-8.34, 7.05], t(2038) = -0.16, p = 0.870; Std.
## beta = -0.07, 95% CI [-0.90, 0.76])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-57.95, 34.92], t(2038) = -0.49, p = 0.627;
## Std. beta = -1.24, 95% CI [-6.23, 3.75])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-29.84, 25.64], t(2038) = -0.15, p = 0.882;
## Std. beta = -0.23, 95% CI [-3.21, 2.76])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.07, 3.27], t(2038) = -0.72, p = 0.471; Std.
## beta = -0.20, 95% CI [-0.76, 0.35])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.08, 95% CI [-37.56, 13.39], t(2038) = -0.93, p = 0.352;
## Std. beta = -1.30, 95% CI [-4.04, 1.44])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-5.44, 7.34], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-5.50, 7.80], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.59, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-3.98, 14.61], t(2038) = 1.12, p = 0.262; Std.
## beta = 0.57, 95% CI [-0.43, 1.57])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-1.84, 9.14], t(2038) = 1.30, p = 0.193; Std.
## beta = 0.39, 95% CI [-0.20, 0.98])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.04, 95% CI [-12.66, 8.57], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.22, 95% CI [-1.36, 0.92])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-8.17, 1.53], t(2038) = -1.34, p = 0.179; Std.
## beta = -0.36, 95% CI [-0.88, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -6.88, 95% CI [-15.21, 1.44], t(2038) = -1.62, p = 0.105; Std.
## beta = -0.74, 95% CI [-1.64, 0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-34.87, 16.38], t(2038) = -0.71, p = 0.479;
## Std. beta = -0.99, 95% CI [-3.75, 1.76])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-14.35, 5.78], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.46, 95% CI [-1.54, 0.62])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-2.58, 5.06], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.13, 95% CI [-0.28, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-8.57, 5.34], t(2038) = -0.46, p = 0.649; Std.
## beta = -0.17, 95% CI [-0.92, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.98, 95% CI [-12.63, 2.67], t(2038) = -1.28, p = 0.202; Std.
## beta = -0.54, 95% CI [-1.36, 0.29])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.82, 5.42], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.09, 95% CI [-0.41, 0.58])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.35, 95% CI [-0.64, 17.35], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.90, 95% CI [-0.07, 1.87])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.67, 10.87], t(2038) = 1.73, p = 0.083; Std.
## beta = 0.55, 95% CI [-0.07, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.17, 3.97], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.77, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.79, 1.60], t(2038) = -1.11, p = 0.267; Std.
## beta = -0.23, 95% CI [-0.62, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.78, 95% CI [-50.23, -9.34], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.20, 95% CI [-5.40, -1.00])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-7.02, 10.85], t(2038) = 0.42, p = 0.674; Std.
## beta = 0.21, 95% CI [-0.75, 1.17])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.01, 95% CI [-10.05, 16.07], t(2038) = 0.45, p = 0.651; Std.
## beta = 0.32, 95% CI [-1.08, 1.73])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-14.76, 8.47], t(2038) = -0.53, p = 0.596; Std.
## beta = -0.34, 95% CI [-1.59, 0.91])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SS_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to SS_5yrPreDx = 0, is at 42.83 (95% CI [39.78, 45.88], t(2038) =
## 27.55, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.19, 95% CI [-6.61, -3.76], t(2038) = -7.12, p < .001; Std. beta = -0.46, 95%
## CI [-0.56, -0.36])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -10.89, 95% CI [-21.36, -0.42], t(2038) = -2.04, p = 0.042; Std. beta = -0.07,
## 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-13.17, 57.15], t(2038) = 1.23, p = 0.220; Std. beta = -2.67,
## 95% CI [-6.24, 0.89])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.71, 95% CI [5.34, 44.09], t(2038) = 2.50, p = 0.012; Std. beta = 1.57, 95%
## CI [0.34, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.42, 95% CI [-23.56, 12.73], t(2038) = -0.59, p = 0.558; Std. beta = -0.54,
## 95% CI [-1.93, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.88, 95% CI [-29.13, 1.37], t(2038) = -1.79, p = 0.074; Std. beta = -1.24,
## 95% CI [-2.67, 0.18])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-14.59, 23.30], t(2038) = 0.45, p = 0.652; Std. beta = 0.61,
## 95% CI [-0.72, 1.95])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-1.81, 12.62], t(2038) = 1.47, p = 0.142; Std. beta = 0.11, 95%
## CI [-0.35, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-24.91, 12.13], t(2038) = -0.68, p = 0.499; Std. beta = -0.41,
## 95% CI [-1.66, 0.83])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.07, 95% CI [15.15, 24.99], t(2038) = 7.99, p < .001; Std. beta = 1.26, 95%
## CI [0.94, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.63, 95% CI [-2.12, 17.39], t(2038) = 1.53, p = 0.125; Std. beta = 0.40, 95%
## CI [-0.23, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.00, 3.62], t(2038) = -0.31, p = 0.755; Std. beta = 0.04,
## 95% CI [-0.25, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.11, 95% CI [-19.22, 1.00], t(2038) = -1.77, p = 0.077; Std. beta = -0.40,
## 95% CI [-1.23, 0.43])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.74, 95% CI [-3.12, 6.60], t(2038) = 0.70, p = 0.484; Std. beta = 0.10, 95%
## CI [-0.22, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-10.08, 3.09], t(2038) = -1.04, p = 0.298; Std. beta = -0.11,
## 95% CI [-0.54, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.01, 95% CI [-7.77, 29.79], t(2038) = 1.15, p = 0.251; Std. beta = -0.58,
## 95% CI [-2.13, 0.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.50, 95% CI [-24.29, 5.29], t(2038) = -1.26, p = 0.208; Std. beta = -0.22,
## 95% CI [-1.17, 0.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.07, 95% CI [-24.97, 31.11], t(2038) = 0.21, p = 0.830; Std. beta = 0.21,
## 95% CI [-1.69, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.82, 16.29], t(2038) = 0.58, p = 0.560; Std. beta = 0.71, 95%
## CI [-0.13, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.99, 95% CI [-28.32, 8.33], t(2038) = -1.07, p = 0.285; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-24.22, 4.36], t(2038) = -1.36, p = 0.173; Std. beta = -0.73,
## 95% CI [-1.66, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.29, 95% CI [-34.65, 24.07], t(2038) = -0.35, p = 0.724; Std. beta = -1.47,
## 95% CI [-4.64, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.33, 95% CI [-50.04, 3.37], t(2038) = -1.71, p = 0.087; Std. beta = -1.78,
## 95% CI [-4.28, 0.71])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.77, 95% CI [-17.50, 5.97], t(2038) = -0.96, p = 0.335; Std. beta = -0.57,
## 95% CI [-1.37, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.96, 85.41], t(2038) = 4.31, p < .001; Std. beta = 3.97, 95%
## CI [2.16, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.28, 95% CI [-20.43, 17.88], t(2038) = -0.13, p = 0.896; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-17.07, 4.65], t(2038) = -1.12, p = 0.262; Std. beta = -0.33,
## 95% CI [-1.11, 0.45])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.63, 7.23], t(2038) = -0.66, p = 0.507; Std. beta = -0.14,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-37.34, 12.45], t(2038) = -0.98, p = 0.327; Std. beta =
## -0.33, 95% CI [-1.89, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.76, 95% CI [-18.15, -1.37], t(2038) = -2.28, p = 0.023; Std. beta = -0.31,
## 95% CI [-0.92, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.43, 95% CI [-28.58, -4.29], t(2038) = -2.65, p = 0.008; Std. beta = -1.31,
## 95% CI [-2.43, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-8.08, 11.64], t(2038) = 0.35, p = 0.724; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 8.37, 95% CI [-9.02, 25.75], t(2038) = 0.94, p = 0.345; Std. beta = -0.10,
## 95% CI [-1.23, 1.03])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.54, 95% CI [-33.04, -2.04], t(2038) = -2.22, p = 0.027; Std. beta = -2.08,
## 95% CI [-4.51, 0.34])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-21.92, 30.59], t(2038) = 0.32, p = 0.746; Std. beta = -0.12,
## 95% CI [-1.72, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-11.11, 11.51], t(2038) = 0.03, p = 0.972; Std. beta = 0.13,
## 95% CI [-0.57, 0.84])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-7.16, 18.90], t(2038) = 0.88, p = 0.377; Std. beta = 0.24, 95%
## CI [-0.66, 1.14])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-17.59, 9.44], t(2038) = -0.59, p = 0.554; Std. beta = -0.76,
## 95% CI [-1.76, 0.24])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-14.54, 4.99], t(2038) = -0.96, p = 0.338; Std. beta = -0.25,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.24, 2.39], t(2038) = -1.66, p = 0.098; Std. beta = -0.06,
## 95% CI [-1.12, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-8.38, 14.94], t(2038) = 0.55, p = 0.581; Std. beta = 0.72, 95%
## CI [-0.09, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.07, 95% CI [-10.64, 14.77], t(2038) = 0.32, p = 0.750; Std. beta = -0.02,
## 95% CI [-0.84, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-10.25, 7.06], t(2038) = -0.36, p = 0.718; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-20.91, 31.17], t(2038) = 0.39, p = 0.699; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-15.19, 21.24], t(2038) = 0.33, p = 0.745; Std. beta = 0.39,
## 95% CI [-0.90, 1.68])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-26.83, 3.48], t(2038) = -1.51, p = 0.131; Std. beta = -0.50,
## 95% CI [-1.80, 0.81])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-16.22, 0.79], t(2038) = -1.78, p = 0.075; Std. beta = -0.83,
## 95% CI [-1.85, 0.20])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.72, 95% CI [-1.38, 8.83], t(2038) = 1.43, p = 0.153;
## Std. beta = 0.08, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -42.92, 95% CI [-80.95, -4.89], t(2038) = -2.21, p = 0.027;
## Std. beta = -4.61, 95% CI [-8.70, -0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-12.63, 10.64], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-14.02, 10.49], t(2038) = -0.28, p = 0.778;
## Std. beta = -0.19, 95% CI [-1.51, 1.13])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-17.97, 11.66], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-6.58, 13.17], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.35, 95% CI [-0.71, 1.42])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-5.39, 0.09], t(2038) = -1.89, p = 0.058; Std.
## beta = -0.28, 95% CI [-0.58, 9.98e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-8.11, 8.46], t(2038) = 0.04, p = 0.967; Std.
## beta = 0.02, 95% CI [-0.87, 0.91])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.03, 1.10], t(2038) = -0.91, p = 0.361; Std.
## beta = -0.10, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-5.46, 3.11], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-1.06, 2.78], t(2038) = 0.88, p = 0.380; Std.
## beta = 0.09, 95% CI [-0.11, 0.30])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-5.09, 9.48], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.24, 95% CI [-0.55, 1.02])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.31, 1.85], t(2038) = -0.22, p = 0.829; Std.
## beta = -0.02, 95% CI [-0.25, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-1.83, 4.45], t(2038) = 0.82, p = 0.413; Std.
## beta = 0.14, 95% CI [-0.20, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.62, 95% CI [-29.61, 2.36], t(2038) = -1.67, p = 0.095;
## Std. beta = -1.46, 95% CI [-3.18, 0.25])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.35, 95% CI [-2.32, 11.01], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.47, 95% CI [-0.25, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-0.81, 10.22], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.51, 95% CI [-0.09, 1.10])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.27, 9.39], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.17, 95% CI [-0.67, 1.01])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-8.34, 7.05], t(2038) = -0.16, p = 0.870; Std.
## beta = -0.07, 95% CI [-0.90, 0.76])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-57.95, 34.92], t(2038) = -0.49, p = 0.627;
## Std. beta = -1.24, 95% CI [-6.23, 3.75])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-29.84, 25.64], t(2038) = -0.15, p = 0.882;
## Std. beta = -0.23, 95% CI [-3.21, 2.76])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.07, 3.27], t(2038) = -0.72, p = 0.471; Std.
## beta = -0.20, 95% CI [-0.76, 0.35])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.08, 95% CI [-37.56, 13.39], t(2038) = -0.93, p = 0.352;
## Std. beta = -1.30, 95% CI [-4.04, 1.44])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-5.44, 7.34], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-5.50, 7.80], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.59, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-3.98, 14.61], t(2038) = 1.12, p = 0.262; Std.
## beta = 0.57, 95% CI [-0.43, 1.57])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-1.84, 9.14], t(2038) = 1.30, p = 0.193; Std.
## beta = 0.39, 95% CI [-0.20, 0.98])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.04, 95% CI [-12.66, 8.57], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.22, 95% CI [-1.36, 0.92])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-8.17, 1.53], t(2038) = -1.34, p = 0.179; Std.
## beta = -0.36, 95% CI [-0.88, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -6.88, 95% CI [-15.21, 1.44], t(2038) = -1.62, p = 0.105; Std.
## beta = -0.74, 95% CI [-1.64, 0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-34.87, 16.38], t(2038) = -0.71, p = 0.479;
## Std. beta = -0.99, 95% CI [-3.75, 1.76])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-14.35, 5.78], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.46, 95% CI [-1.54, 0.62])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-2.58, 5.06], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.13, 95% CI [-0.28, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-8.57, 5.34], t(2038) = -0.46, p = 0.649; Std.
## beta = -0.17, 95% CI [-0.92, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.98, 95% CI [-12.63, 2.67], t(2038) = -1.28, p = 0.202; Std.
## beta = -0.54, 95% CI [-1.36, 0.29])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.82, 5.42], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.09, 95% CI [-0.41, 0.58])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.35, 95% CI [-0.64, 17.35], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.90, 95% CI [-0.07, 1.87])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.67, 10.87], t(2038) = 1.73, p = 0.083; Std.
## beta = 0.55, 95% CI [-0.07, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.17, 3.97], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.77, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.79, 1.60], t(2038) = -1.11, p = 0.267; Std.
## beta = -0.23, 95% CI [-0.62, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.78, 95% CI [-50.23, -9.34], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.20, 95% CI [-5.40, -1.00])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-7.02, 10.85], t(2038) = 0.42, p = 0.674; Std.
## beta = 0.21, 95% CI [-0.75, 1.17])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.01, 95% CI [-10.05, 16.07], t(2038) = 0.45, p = 0.651; Std.
## beta = 0.32, 95% CI [-1.08, 1.73])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-14.76, 8.47], t(2038) = -0.53, p = 0.596; Std.
## beta = -0.34, 95% CI [-1.59, 0.91])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.32. The model's intercept, corresponding to site =
## Simmons, is at 42.83 (95% CI [39.78, 45.88], t(2038) = 27.55, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.19, 95% CI [-6.61, -3.76], t(2038) = -7.12, p < .001; Std. beta = -0.46, 95%
## CI [-0.56, -0.36])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -10.89, 95% CI [-21.36, -0.42], t(2038) = -2.04, p = 0.042; Std. beta = -0.07,
## 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-13.17, 57.15], t(2038) = 1.23, p = 0.220; Std. beta = -2.67,
## 95% CI [-6.24, 0.89])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.71, 95% CI [5.34, 44.09], t(2038) = 2.50, p = 0.012; Std. beta = 1.57, 95%
## CI [0.34, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.42, 95% CI [-23.56, 12.73], t(2038) = -0.59, p = 0.558; Std. beta = -0.54,
## 95% CI [-1.93, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.88, 95% CI [-29.13, 1.37], t(2038) = -1.79, p = 0.074; Std. beta = -1.24,
## 95% CI [-2.67, 0.18])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-14.59, 23.30], t(2038) = 0.45, p = 0.652; Std. beta = 0.61,
## 95% CI [-0.72, 1.95])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-1.81, 12.62], t(2038) = 1.47, p = 0.142; Std. beta = 0.11, 95%
## CI [-0.35, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-24.91, 12.13], t(2038) = -0.68, p = 0.499; Std. beta = -0.41,
## 95% CI [-1.66, 0.83])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.07, 95% CI [15.15, 24.99], t(2038) = 7.99, p < .001; Std. beta = 1.26, 95%
## CI [0.94, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.63, 95% CI [-2.12, 17.39], t(2038) = 1.53, p = 0.125; Std. beta = 0.40, 95%
## CI [-0.23, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.00, 3.62], t(2038) = -0.31, p = 0.755; Std. beta = 0.04,
## 95% CI [-0.25, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.11, 95% CI [-19.22, 1.00], t(2038) = -1.77, p = 0.077; Std. beta = -0.40,
## 95% CI [-1.23, 0.43])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.74, 95% CI [-3.12, 6.60], t(2038) = 0.70, p = 0.484; Std. beta = 0.10, 95%
## CI [-0.22, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-10.08, 3.09], t(2038) = -1.04, p = 0.298; Std. beta = -0.11,
## 95% CI [-0.54, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.01, 95% CI [-7.77, 29.79], t(2038) = 1.15, p = 0.251; Std. beta = -0.58,
## 95% CI [-2.13, 0.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.50, 95% CI [-24.29, 5.29], t(2038) = -1.26, p = 0.208; Std. beta = -0.22,
## 95% CI [-1.17, 0.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.07, 95% CI [-24.97, 31.11], t(2038) = 0.21, p = 0.830; Std. beta = 0.21,
## 95% CI [-1.69, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.82, 16.29], t(2038) = 0.58, p = 0.560; Std. beta = 0.71, 95%
## CI [-0.13, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.99, 95% CI [-28.32, 8.33], t(2038) = -1.07, p = 0.285; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-24.22, 4.36], t(2038) = -1.36, p = 0.173; Std. beta = -0.73,
## 95% CI [-1.66, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.29, 95% CI [-34.65, 24.07], t(2038) = -0.35, p = 0.724; Std. beta = -1.47,
## 95% CI [-4.64, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.33, 95% CI [-50.04, 3.37], t(2038) = -1.71, p = 0.087; Std. beta = -1.78,
## 95% CI [-4.28, 0.71])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.77, 95% CI [-17.50, 5.97], t(2038) = -0.96, p = 0.335; Std. beta = -0.57,
## 95% CI [-1.37, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.96, 85.41], t(2038) = 4.31, p < .001; Std. beta = 3.97, 95%
## CI [2.16, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.28, 95% CI [-20.43, 17.88], t(2038) = -0.13, p = 0.896; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-17.07, 4.65], t(2038) = -1.12, p = 0.262; Std. beta = -0.33,
## 95% CI [-1.11, 0.45])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.63, 7.23], t(2038) = -0.66, p = 0.507; Std. beta = -0.14,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-37.34, 12.45], t(2038) = -0.98, p = 0.327; Std. beta =
## -0.33, 95% CI [-1.89, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.76, 95% CI [-18.15, -1.37], t(2038) = -2.28, p = 0.023; Std. beta = -0.31,
## 95% CI [-0.92, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.43, 95% CI [-28.58, -4.29], t(2038) = -2.65, p = 0.008; Std. beta = -1.31,
## 95% CI [-2.43, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-8.08, 11.64], t(2038) = 0.35, p = 0.724; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 8.37, 95% CI [-9.02, 25.75], t(2038) = 0.94, p = 0.345; Std. beta = -0.10,
## 95% CI [-1.23, 1.03])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.54, 95% CI [-33.04, -2.04], t(2038) = -2.22, p = 0.027; Std. beta = -2.08,
## 95% CI [-4.51, 0.34])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-21.92, 30.59], t(2038) = 0.32, p = 0.746; Std. beta = -0.12,
## 95% CI [-1.72, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-11.11, 11.51], t(2038) = 0.03, p = 0.972; Std. beta = 0.13,
## 95% CI [-0.57, 0.84])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-7.16, 18.90], t(2038) = 0.88, p = 0.377; Std. beta = 0.24, 95%
## CI [-0.66, 1.14])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-17.59, 9.44], t(2038) = -0.59, p = 0.554; Std. beta = -0.76,
## 95% CI [-1.76, 0.24])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-14.54, 4.99], t(2038) = -0.96, p = 0.338; Std. beta = -0.25,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.24, 2.39], t(2038) = -1.66, p = 0.098; Std. beta = -0.06,
## 95% CI [-1.12, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-8.38, 14.94], t(2038) = 0.55, p = 0.581; Std. beta = 0.72, 95%
## CI [-0.09, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.07, 95% CI [-10.64, 14.77], t(2038) = 0.32, p = 0.750; Std. beta = -0.02,
## 95% CI [-0.84, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-10.25, 7.06], t(2038) = -0.36, p = 0.718; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-20.91, 31.17], t(2038) = 0.39, p = 0.699; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-15.19, 21.24], t(2038) = 0.33, p = 0.745; Std. beta = 0.39,
## 95% CI [-0.90, 1.68])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-26.83, 3.48], t(2038) = -1.51, p = 0.131; Std. beta = -0.50,
## 95% CI [-1.80, 0.81])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-16.22, 0.79], t(2038) = -1.78, p = 0.075; Std. beta = -0.83,
## 95% CI [-1.85, 0.20])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.72, 95% CI [-1.38, 8.83], t(2038) = 1.43, p = 0.153;
## Std. beta = 0.08, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -42.92, 95% CI [-80.95, -4.89], t(2038) = -2.21, p = 0.027;
## Std. beta = -4.61, 95% CI [-8.70, -0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-12.63, 10.64], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-14.02, 10.49], t(2038) = -0.28, p = 0.778;
## Std. beta = -0.19, 95% CI [-1.51, 1.13])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-17.97, 11.66], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-6.58, 13.17], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.35, 95% CI [-0.71, 1.42])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-5.39, 0.09], t(2038) = -1.89, p = 0.058; Std.
## beta = -0.28, 95% CI [-0.58, 9.98e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-8.11, 8.46], t(2038) = 0.04, p = 0.967; Std.
## beta = 0.02, 95% CI [-0.87, 0.91])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.03, 1.10], t(2038) = -0.91, p = 0.361; Std.
## beta = -0.10, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-5.46, 3.11], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-1.06, 2.78], t(2038) = 0.88, p = 0.380; Std.
## beta = 0.09, 95% CI [-0.11, 0.30])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-5.09, 9.48], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.24, 95% CI [-0.55, 1.02])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.31, 1.85], t(2038) = -0.22, p = 0.829; Std.
## beta = -0.02, 95% CI [-0.25, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-1.83, 4.45], t(2038) = 0.82, p = 0.413; Std.
## beta = 0.14, 95% CI [-0.20, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.62, 95% CI [-29.61, 2.36], t(2038) = -1.67, p = 0.095;
## Std. beta = -1.46, 95% CI [-3.18, 0.25])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.35, 95% CI [-2.32, 11.01], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.47, 95% CI [-0.25, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-0.81, 10.22], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.51, 95% CI [-0.09, 1.10])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.27, 9.39], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.17, 95% CI [-0.67, 1.01])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-8.34, 7.05], t(2038) = -0.16, p = 0.870; Std.
## beta = -0.07, 95% CI [-0.90, 0.76])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-57.95, 34.92], t(2038) = -0.49, p = 0.627;
## Std. beta = -1.24, 95% CI [-6.23, 3.75])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-29.84, 25.64], t(2038) = -0.15, p = 0.882;
## Std. beta = -0.23, 95% CI [-3.21, 2.76])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.07, 3.27], t(2038) = -0.72, p = 0.471; Std.
## beta = -0.20, 95% CI [-0.76, 0.35])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.08, 95% CI [-37.56, 13.39], t(2038) = -0.93, p = 0.352;
## Std. beta = -1.30, 95% CI [-4.04, 1.44])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-5.44, 7.34], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-5.50, 7.80], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.59, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-3.98, 14.61], t(2038) = 1.12, p = 0.262; Std.
## beta = 0.57, 95% CI [-0.43, 1.57])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-1.84, 9.14], t(2038) = 1.30, p = 0.193; Std.
## beta = 0.39, 95% CI [-0.20, 0.98])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.04, 95% CI [-12.66, 8.57], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.22, 95% CI [-1.36, 0.92])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-8.17, 1.53], t(2038) = -1.34, p = 0.179; Std.
## beta = -0.36, 95% CI [-0.88, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -6.88, 95% CI [-15.21, 1.44], t(2038) = -1.62, p = 0.105; Std.
## beta = -0.74, 95% CI [-1.64, 0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-34.87, 16.38], t(2038) = -0.71, p = 0.479;
## Std. beta = -0.99, 95% CI [-3.75, 1.76])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-14.35, 5.78], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.46, 95% CI [-1.54, 0.62])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-2.58, 5.06], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.13, 95% CI [-0.28, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-8.57, 5.34], t(2038) = -0.46, p = 0.649; Std.
## beta = -0.17, 95% CI [-0.92, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.98, 95% CI [-12.63, 2.67], t(2038) = -1.28, p = 0.202; Std.
## beta = -0.54, 95% CI [-1.36, 0.29])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.82, 5.42], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.09, 95% CI [-0.41, 0.58])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.35, 95% CI [-0.64, 17.35], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.90, 95% CI [-0.07, 1.87])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.67, 10.87], t(2038) = 1.73, p = 0.083; Std.
## beta = 0.55, 95% CI [-0.07, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.17, 3.97], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.77, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.79, 1.60], t(2038) = -1.11, p = 0.267; Std.
## beta = -0.23, 95% CI [-0.62, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.78, 95% CI [-50.23, -9.34], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.20, 95% CI [-5.40, -1.00])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-7.02, 10.85], t(2038) = 0.42, p = 0.674; Std.
## beta = 0.21, 95% CI [-0.75, 1.17])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.01, 95% CI [-10.05, 16.07], t(2038) = 0.45, p = 0.651; Std.
## beta = 0.32, 95% CI [-1.08, 1.73])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-14.76, 8.47], t(2038) = -0.53, p = 0.596; Std.
## beta = -0.34, 95% CI [-1.59, 0.91])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to cohort = CARE-PF, is at 42.83 (95% CI [39.78, 45.88], t(2038)
## = 27.55, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.19, 95% CI [-6.61, -3.76], t(2038) = -7.12, p < .001; Std. beta = -0.46, 95%
## CI [-0.56, -0.36])
## - The effect of SS 5yrPreDx is statistically significant and negative (beta =
## -10.89, 95% CI [-21.36, -0.42], t(2038) = -2.04, p = 0.042; Std. beta = -0.07,
## 95% CI [-0.21, 0.06])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 21.99, 95% CI [-13.17, 57.15], t(2038) = 1.23, p = 0.220; Std. beta = -2.67,
## 95% CI [-6.24, 0.89])
## - The effect of site [03R] is statistically significant and positive (beta =
## 24.71, 95% CI [5.34, 44.09], t(2038) = 2.50, p = 0.012; Std. beta = 1.57, 95%
## CI [0.34, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.42, 95% CI [-23.56, 12.73], t(2038) = -0.59, p = 0.558; Std. beta = -0.54,
## 95% CI [-1.93, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.88, 95% CI [-29.13, 1.37], t(2038) = -1.79, p = 0.074; Std. beta = -1.24,
## 95% CI [-2.67, 0.18])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.36, 95% CI [-14.59, 23.30], t(2038) = 0.45, p = 0.652; Std. beta = 0.61,
## 95% CI [-0.72, 1.95])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.40, 95% CI [-1.81, 12.62], t(2038) = 1.47, p = 0.142; Std. beta = 0.11, 95%
## CI [-0.35, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-24.91, 12.13], t(2038) = -0.68, p = 0.499; Std. beta = -0.41,
## 95% CI [-1.66, 0.83])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.07, 95% CI [15.15, 24.99], t(2038) = 7.99, p < .001; Std. beta = 1.26, 95%
## CI [0.94, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.63, 95% CI [-2.12, 17.39], t(2038) = 1.53, p = 0.125; Std. beta = 0.40, 95%
## CI [-0.23, 1.04])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.00, 3.62], t(2038) = -0.31, p = 0.755; Std. beta = 0.04,
## 95% CI [-0.25, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.11, 95% CI [-19.22, 1.00], t(2038) = -1.77, p = 0.077; Std. beta = -0.40,
## 95% CI [-1.23, 0.43])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.74, 95% CI [-3.12, 6.60], t(2038) = 0.70, p = 0.484; Std. beta = 0.10, 95%
## CI [-0.22, 0.41])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-10.08, 3.09], t(2038) = -1.04, p = 0.298; Std. beta = -0.11,
## 95% CI [-0.54, 0.32])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.01, 95% CI [-7.77, 29.79], t(2038) = 1.15, p = 0.251; Std. beta = -0.58,
## 95% CI [-2.13, 0.98])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.50, 95% CI [-24.29, 5.29], t(2038) = -1.26, p = 0.208; Std. beta = -0.22,
## 95% CI [-1.17, 0.73])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.07, 95% CI [-24.97, 31.11], t(2038) = 0.21, p = 0.830; Std. beta = 0.21,
## 95% CI [-1.69, 2.10])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 3.74, 95% CI [-8.82, 16.29], t(2038) = 0.58, p = 0.560; Std. beta = 0.71, 95%
## CI [-0.13, 1.55])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.99, 95% CI [-28.32, 8.33], t(2038) = -1.07, p = 0.285; Std. beta = -0.52,
## 95% CI [-1.77, 0.72])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-24.22, 4.36], t(2038) = -1.36, p = 0.173; Std. beta = -0.73,
## 95% CI [-1.66, 0.19])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -5.29, 95% CI [-34.65, 24.07], t(2038) = -0.35, p = 0.724; Std. beta = -1.47,
## 95% CI [-4.64, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.33, 95% CI [-50.04, 3.37], t(2038) = -1.71, p = 0.087; Std. beta = -1.78,
## 95% CI [-4.28, 0.71])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.77, 95% CI [-17.50, 5.97], t(2038) = -0.96, p = 0.335; Std. beta = -0.57,
## 95% CI [-1.37, 0.22])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.69, 95% CI [31.96, 85.41], t(2038) = 4.31, p < .001; Std. beta = 3.97, 95%
## CI [2.16, 5.77])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.28, 95% CI [-20.43, 17.88], t(2038) = -0.13, p = 0.896; Std. beta = -1.26,
## 95% CI [-3.65, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-17.07, 4.65], t(2038) = -1.12, p = 0.262; Std. beta = -0.33,
## 95% CI [-1.11, 0.45])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.70, 95% CI [-14.63, 7.23], t(2038) = -0.66, p = 0.507; Std. beta = -0.14,
## 95% CI [-0.92, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-37.34, 12.45], t(2038) = -0.98, p = 0.327; Std. beta =
## -0.33, 95% CI [-1.89, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.76, 95% CI [-18.15, -1.37], t(2038) = -2.28, p = 0.023; Std. beta = -0.31,
## 95% CI [-0.92, 0.31])
## - The effect of site [23R] is statistically significant and negative (beta =
## -16.43, 95% CI [-28.58, -4.29], t(2038) = -2.65, p = 0.008; Std. beta = -1.31,
## 95% CI [-2.43, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-8.08, 11.64], t(2038) = 0.35, p = 0.724; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 8.37, 95% CI [-9.02, 25.75], t(2038) = 0.94, p = 0.345; Std. beta = -0.10,
## 95% CI [-1.23, 1.03])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.54, 95% CI [-33.04, -2.04], t(2038) = -2.22, p = 0.027; Std. beta = -2.08,
## 95% CI [-4.51, 0.34])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 4.33, 95% CI [-21.92, 30.59], t(2038) = 0.32, p = 0.746; Std. beta = -0.12,
## 95% CI [-1.72, 1.48])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.20, 95% CI [-11.11, 11.51], t(2038) = 0.03, p = 0.972; Std. beta = 0.13,
## 95% CI [-0.57, 0.84])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.87, 95% CI [-7.16, 18.90], t(2038) = 0.88, p = 0.377; Std. beta = 0.24, 95%
## CI [-0.66, 1.14])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-17.59, 9.44], t(2038) = -0.59, p = 0.554; Std. beta = -0.76,
## 95% CI [-1.76, 0.24])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.77, 95% CI [-14.54, 4.99], t(2038) = -0.96, p = 0.338; Std. beta = -0.25,
## 95% CI [-0.90, 0.41])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.24, 2.39], t(2038) = -1.66, p = 0.098; Std. beta = -0.06,
## 95% CI [-1.12, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.28, 95% CI [-8.38, 14.94], t(2038) = 0.55, p = 0.581; Std. beta = 0.72, 95%
## CI [-0.09, 1.53])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.07, 95% CI [-10.64, 14.77], t(2038) = 0.32, p = 0.750; Std. beta = -0.02,
## 95% CI [-0.84, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-10.25, 7.06], t(2038) = -0.36, p = 0.718; Std. beta = -0.31,
## 95% CI [-0.87, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 5.13, 95% CI [-20.91, 31.17], t(2038) = 0.39, p = 0.699; Std. beta = -2.54,
## 95% CI [-4.62, -0.47])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-15.19, 21.24], t(2038) = 0.33, p = 0.745; Std. beta = 0.39,
## 95% CI [-0.90, 1.68])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.67, 95% CI [-26.83, 3.48], t(2038) = -1.51, p = 0.131; Std. beta = -0.50,
## 95% CI [-1.80, 0.81])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.72, 95% CI [-16.22, 0.79], t(2038) = -1.78, p = 0.075; Std. beta = -0.83,
## 95% CI [-1.85, 0.20])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.72, 95% CI [-1.38, 8.83], t(2038) = 1.43, p = 0.153;
## Std. beta = 0.08, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -42.92, 95% CI [-80.95, -4.89], t(2038) = -2.21, p = 0.027;
## Std. beta = -4.61, 95% CI [-8.70, -0.53])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.99, 95% CI [-12.63, 10.64], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-14.02, 10.49], t(2038) = -0.28, p = 0.778;
## Std. beta = -0.19, 95% CI [-1.51, 1.13])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-17.97, 11.66], t(2038) = -0.42, p = 0.676;
## Std. beta = -0.34, 95% CI [-1.93, 1.25])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.30, 95% CI [-6.58, 13.17], t(2038) = 0.65, p = 0.513; Std.
## beta = 0.35, 95% CI [-0.71, 1.42])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.65, 95% CI [-5.39, 0.09], t(2038) = -1.89, p = 0.058; Std.
## beta = -0.28, 95% CI [-0.58, 9.98e-03])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-8.11, 8.46], t(2038) = 0.04, p = 0.967; Std.
## beta = 0.02, 95% CI [-0.87, 0.91])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.96, 95% CI [-3.03, 1.10], t(2038) = -0.91, p = 0.361; Std.
## beta = -0.10, 95% CI [-0.33, 0.12])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.17, 95% CI [-5.46, 3.11], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.86, 95% CI [-1.06, 2.78], t(2038) = 0.88, p = 0.380; Std.
## beta = 0.09, 95% CI [-0.11, 0.30])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-5.09, 9.48], t(2038) = 0.59, p = 0.554; Std.
## beta = 0.24, 95% CI [-0.55, 1.02])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-2.31, 1.85], t(2038) = -0.22, p = 0.829; Std.
## beta = -0.02, 95% CI [-0.25, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-1.83, 4.45], t(2038) = 0.82, p = 0.413; Std.
## beta = 0.14, 95% CI [-0.20, 0.48])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.62, 95% CI [-29.61, 2.36], t(2038) = -1.67, p = 0.095;
## Std. beta = -1.46, 95% CI [-3.18, 0.25])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.35, 95% CI [-2.32, 11.01], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.47, 95% CI [-0.25, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-0.81, 10.22], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.51, 95% CI [-0.09, 1.10])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.56, 95% CI [-6.27, 9.39], t(2038) = 0.39, p = 0.696; Std.
## beta = 0.17, 95% CI [-0.67, 1.01])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.64, 95% CI [-8.34, 7.05], t(2038) = -0.16, p = 0.870; Std.
## beta = -0.07, 95% CI [-0.90, 0.76])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-57.95, 34.92], t(2038) = -0.49, p = 0.627;
## Std. beta = -1.24, 95% CI [-6.23, 3.75])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.10, 95% CI [-29.84, 25.64], t(2038) = -0.15, p = 0.882;
## Std. beta = -0.23, 95% CI [-3.21, 2.76])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.07, 3.27], t(2038) = -0.72, p = 0.471; Std.
## beta = -0.20, 95% CI [-0.76, 0.35])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.08, 95% CI [-37.56, 13.39], t(2038) = -0.93, p = 0.352;
## Std. beta = -1.30, 95% CI [-4.04, 1.44])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-5.44, 7.34], t(2038) = 0.29, p = 0.771; Std.
## beta = 0.10, 95% CI [-0.59, 0.79])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-5.50, 7.80], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.59, 0.84])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-3.98, 14.61], t(2038) = 1.12, p = 0.262; Std.
## beta = 0.57, 95% CI [-0.43, 1.57])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-1.84, 9.14], t(2038) = 1.30, p = 0.193; Std.
## beta = 0.39, 95% CI [-0.20, 0.98])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.04, 95% CI [-12.66, 8.57], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.22, 95% CI [-1.36, 0.92])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-8.17, 1.53], t(2038) = -1.34, p = 0.179; Std.
## beta = -0.36, 95% CI [-0.88, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -6.88, 95% CI [-15.21, 1.44], t(2038) = -1.62, p = 0.105; Std.
## beta = -0.74, 95% CI [-1.64, 0.16])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.25, 95% CI [-34.87, 16.38], t(2038) = -0.71, p = 0.479;
## Std. beta = -0.99, 95% CI [-3.75, 1.76])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.29, 95% CI [-14.35, 5.78], t(2038) = -0.84, p = 0.403; Std.
## beta = -0.46, 95% CI [-1.54, 0.62])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.24, 95% CI [-2.58, 5.06], t(2038) = 0.64, p = 0.525; Std.
## beta = 0.13, 95% CI [-0.28, 0.54])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-8.57, 5.34], t(2038) = -0.46, p = 0.649; Std.
## beta = -0.17, 95% CI [-0.92, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.98, 95% CI [-12.63, 2.67], t(2038) = -1.28, p = 0.202; Std.
## beta = -0.54, 95% CI [-1.36, 0.29])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.82, 5.42], t(2038) = 0.34, p = 0.734; Std.
## beta = 0.09, 95% CI [-0.41, 0.58])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.35, 95% CI [-0.64, 17.35], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.90, 95% CI [-0.07, 1.87])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.67, 10.87], t(2038) = 1.73, p = 0.083; Std.
## beta = 0.55, 95% CI [-0.07, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.17, 3.97], t(2038) = -0.56, p = 0.573; Std.
## beta = -0.17, 95% CI [-0.77, 0.43])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.79, 1.60], t(2038) = -1.11, p = 0.267; Std.
## beta = -0.23, 95% CI [-0.62, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.78, 95% CI [-50.23, -9.34], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.20, 95% CI [-5.40, -1.00])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.92, 95% CI [-7.02, 10.85], t(2038) = 0.42, p = 0.674; Std.
## beta = 0.21, 95% CI [-0.75, 1.17])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.01, 95% CI [-10.05, 16.07], t(2038) = 0.45, p = 0.651; Std.
## beta = 0.32, 95% CI [-1.08, 1.73])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-14.76, 8.47], t(2038) = -0.53, p = 0.596; Std.
## beta = -0.34, 95% CI [-1.59, 0.91])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*SS_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14674.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1095 -0.4849 -0.0038 0.4379 7.0930
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 138.09 11.751
## time_firstPFT 10.99 3.315 -0.28
## Residual 41.78 6.464
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 40.13723 5.04413 7.957
## time_firstPFT -3.89552 2.27793 -1.710
## SS_5yrPreDx -9.63184 5.42816 -1.774
## disadv -5.93121 2.33731 -2.538
## dich_RaceNon-White -2.74553 2.28346 -1.202
## sexF -2.28924 1.42529 -1.606
## age_dx 0.13415 0.07418 1.808
## smokeHxFormer -2.58893 1.41132 -1.834
## smokeHxAlways 8.78304 7.05854 1.244
## smokeHxUnknown -2.59995 3.18340 -0.817
## site02R 15.26208 17.95865 0.850
## site03R 20.47351 9.87904 2.072
## site04R -4.94240 9.14958 -0.540
## site05R -14.06940 7.72386 -1.822
## site06R -8.40569 13.47046 -0.624
## site07R 3.63385 3.67871 0.988
## site09R -9.08903 9.37694 -0.969
## site101 20.18213 2.52880 7.981
## site102 6.44623 4.99282 1.291
## site103 -0.69133 2.30537 -0.300
## site104 -8.08880 5.13415 -1.575
## site105 2.23261 2.49553 0.895
## site106 -5.50222 3.40277 -1.617
## site107 8.41872 9.50650 0.886
## site108 -4.27187 7.82013 -0.546
## site10R 3.02610 14.39192 0.210
## site11R 2.57613 6.36182 0.405
## site12R -8.52330 9.24560 -0.922
## site13R -11.63761 7.25397 -1.604
## site14R -7.60992 14.93042 -0.510
## site15R -19.95298 13.51567 -1.476
## site16R -5.84710 6.00648 -0.973
## site17R 62.69604 13.61323 4.606
## site18R -0.01574 9.73776 -0.002
## site19R -6.76999 5.51149 -1.228
## site20R -3.99451 5.53510 -0.722
## site21R -12.16383 12.52937 -0.971
## site22R -12.53244 4.31934 -2.901
## site23R -23.37183 7.71791 -3.028
## site24R 1.23782 4.98480 0.248
## site25R 4.12490 8.96797 0.460
## site28R -15.93546 7.86909 -2.025
## site29R 0.05885 13.28007 0.004
## site31R -0.75580 5.77185 -0.131
## site32R 5.99397 6.61544 0.906
## site33R -5.01118 6.87649 -0.729
## site34R -4.83640 4.93719 -0.980
## site35R -13.75610 7.76389 -1.772
## site36R 2.97654 5.90815 0.504
## site37R 0.40110 6.49876 0.062
## site38R -1.04649 4.37837 -0.239
## site39R 12.77434 13.37509 0.955
## site40R 1.57711 9.22018 0.171
## site41R -12.74522 7.70627 -1.654
## site42R -9.76757 4.35349 -2.244
## time_firstPFT:SS_5yrPreDx 3.61128 2.68602 1.344
## time_firstPFT:disadv 1.42943 1.10002 1.299
## time_firstPFT:dich_RaceNon-White -0.69316 1.11727 -0.620
## time_firstPFT:sexF 0.54328 0.66222 0.820
## time_firstPFT:age_dx -0.03158 0.03452 -0.915
## time_firstPFT:smokeHxFormer -0.76858 0.66937 -1.148
## time_firstPFT:smokeHxAlways -6.11612 6.03707 -1.013
## time_firstPFT:smokeHxUnknown 2.12617 1.66425 1.278
## time_firstPFT:site02R -41.06499 19.48285 -2.108
## time_firstPFT:site03R -0.68832 5.97297 -0.115
## time_firstPFT:site04R -2.43555 6.28135 -0.388
## time_firstPFT:site05R -2.95678 7.57001 -0.391
## time_firstPFT:site07R -2.10800 1.44353 -1.460
## time_firstPFT:site09R 1.32237 4.25991 0.310
## time_firstPFT:site101 -0.75288 1.07609 -0.700
## time_firstPFT:site102 -0.46389 2.21803 -0.209
## time_firstPFT:site103 1.26552 1.02784 1.231
## time_firstPFT:site104 1.79882 3.77466 0.477
## time_firstPFT:site105 -0.06319 1.07766 -0.059
## time_firstPFT:site106 1.84777 1.64261 1.125
## time_firstPFT:site107 -12.74827 8.16424 -1.561
## time_firstPFT:site108 5.19847 3.60681 1.441
## time_firstPFT:site11R 5.30792 2.87357 1.847
## time_firstPFT:site12R 2.05867 4.01961 0.512
## time_firstPFT:site13R -0.58112 3.96105 -0.147
## time_firstPFT:site14R -10.30918 23.69222 -0.435
## time_firstPFT:site15R -2.24419 14.16109 -0.158
## time_firstPFT:site16R -1.90387 2.69442 -0.707
## time_firstPFT:site18R -11.88299 13.00802 -0.914
## time_firstPFT:site19R 1.12096 3.29986 0.340
## time_firstPFT:site20R 0.95603 3.43407 0.278
## time_firstPFT:site21R 5.90939 4.75066 1.244
## time_firstPFT:site22R 4.84754 2.86715 1.691
## time_firstPFT:site23R 21.36894 26.76229 0.798
## time_firstPFT:site24R -2.91448 2.48680 -1.172
## time_firstPFT:site25R -5.76639 4.36432 -1.321
## time_firstPFT:site28R -8.17568 13.14147 -0.622
## time_firstPFT:site29R -2.66018 5.18793 -0.513
## time_firstPFT:site31R 2.10878 2.00071 1.054
## time_firstPFT:site32R -1.07873 3.58463 -0.301
## time_firstPFT:site33R -5.45610 3.99480 -1.366
## time_firstPFT:site34R 1.01120 2.39859 0.422
## time_firstPFT:site35R 9.19162 4.63973 1.981
## time_firstPFT:site36R 5.17748 2.96679 1.745
## time_firstPFT:site37R -1.23128 2.94266 -0.418
## time_firstPFT:site38R -1.97237 1.89815 -1.039
## time_firstPFT:site39R -29.55738 10.51060 -2.812
## time_firstPFT:site40R 1.49855 4.61624 0.325
## time_firstPFT:site41R 3.87790 6.68559 0.580
## time_firstPFT:site42R -3.48925 5.94746 -0.587##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.790
## Unadjusted ICC: 0.527report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SS_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to time_firstPFT = 0, is at 40.14 (95% CI [30.24, 50.03], t(2008)
## = 7.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SS_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to SS_5yrPreDx =
## 0, is at 40.14 (95% CI [30.24, 50.03], t(2008) = 7.96, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to disadv = 0, is at 40.14 (95% CI [30.24,
## 50.03], t(2008) = 7.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to dich_Race = White, is at 40.14 (95% CI
## [30.24, 50.03], t(2008) = 7.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to sex = M, is at 40.14 (95% CI [30.24,
## 50.03], t(2008) = 7.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to age_dx = 0, is at 40.14 (95% CI [30.24,
## 50.03], t(2008) = 7.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to smokeHx = Never, is at 40.14 (95% CI
## [30.24, 50.03], t(2008) = 7.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to site = Simmons, is at 40.14 (95% CI [30.24,
## 50.03], t(2008) = 7.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to cohort =
## CARE-PF, is at 40.14 (95% CI [30.24, 50.03], t(2008) = 7.96, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.90, 95% CI [-8.36, 0.57], t(2008) = -1.71, p = 0.087; Std. beta =
## -0.45, 95% CI [-0.62, -0.29])
## - The effect of SS 5yrPreDx is statistically non-significant and negative (beta
## = -9.63, 95% CI [-20.28, 1.01], t(2008) = -1.77, p = 0.076; Std. beta = -0.06,
## 95% CI [-0.20, 0.08])
## - The effect of disadv is statistically significant and negative (beta = -5.93,
## 95% CI [-10.52, -1.35], t(2008) = -2.54, p = 0.011; Std. beta = -0.07, 95% CI
## [-0.16, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.75, 95% CI [-7.22, 1.73], t(2008) = -1.20, p = 0.229; Std.
## beta = -0.25, 95% CI [-0.56, 0.06])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.29, 95% CI [-5.08, 0.51], t(2008) = -1.61, p = 0.108; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.13, 95% CI [-0.01, 0.28], t(2008) = 1.81, p = 0.071; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.59, 95% CI [-5.36, 0.18], t(2008) = -1.83, p = 0.067; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.78, 95% CI [-5.06, 22.63], t(2008) = 1.24, p = 0.214; Std. beta =
## -1.59e-03, 95% CI [-1.20, 1.20])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.60, 95% CI [-8.84, 3.64], t(2008) = -0.82, p = 0.414; Std. beta =
## 0.03, 95% CI [-0.42, 0.48])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 15.26, 95% CI [-19.96, 50.48], t(2008) = 0.85, p = 0.396; Std. beta = -2.96,
## 95% CI [-6.56, 0.63])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.47, 95% CI [1.10, 39.85], t(2008) = 2.07, p = 0.038; Std. beta = 1.32, 95%
## CI [0.07, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.94, 95% CI [-22.89, 13.00], t(2008) = -0.54, p = 0.589; Std. beta = -0.57,
## 95% CI [-1.97, 0.82])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.07, 95% CI [-29.22, 1.08], t(2008) = -1.82, p = 0.069; Std. beta = -1.24,
## 95% CI [-2.67, 0.19])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.41, 95% CI [-34.82, 18.01], t(2008) = -0.62, p = 0.533; Std. beta = -0.57,
## 95% CI [-2.35, 1.22])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.63, 95% CI [-3.58, 10.85], t(2008) = 0.99, p = 0.323; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.09, 95% CI [-27.48, 9.30], t(2008) = -0.97, p = 0.333; Std. beta = -0.49,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.18, 95% CI [15.22, 25.14], t(2008) = 7.98, p < .001; Std. beta = 1.29, 95%
## CI [0.96, 1.62])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.45, 95% CI [-3.35, 16.24], t(2008) = 1.29, p = 0.197; Std. beta = 0.39, 95%
## CI [-0.25, 1.03])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -0.69, 95% CI [-5.21, 3.83], t(2008) = -0.30, p = 0.764; Std. beta = 0.08,
## 95% CI [-0.23, 0.38])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.09, 95% CI [-18.16, 1.98], t(2008) = -1.58, p = 0.115; Std. beta = -0.37,
## 95% CI [-1.21, 0.47])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-2.66, 7.13], t(2008) = 0.89, p = 0.371; Std. beta = 0.14, 95%
## CI [-0.18, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-12.18, 1.17], t(2008) = -1.62, p = 0.106; Std. beta = -0.19,
## 95% CI [-0.63, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.42, 95% CI [-10.22, 27.06], t(2008) = 0.89, p = 0.376; Std. beta = -0.67,
## 95% CI [-2.23, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.27, 95% CI [-19.61, 11.06], t(2008) = -0.55, p = 0.585; Std. beta = 0.22,
## 95% CI [-0.78, 1.22])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 3.03, 95% CI [-25.20, 31.25], t(2008) = 0.21, p = 0.833; Std. beta = 0.20,
## 95% CI [-1.70, 2.11])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-9.90, 15.05], t(2008) = 0.40, p = 0.686; Std. beta = 0.69, 95%
## CI [-0.16, 1.54])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-26.66, 9.61], t(2008) = -0.92, p = 0.357; Std. beta = -0.38,
## 95% CI [-1.62, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.64, 95% CI [-25.86, 2.59], t(2008) = -1.60, p = 0.109; Std. beta = -0.84,
## 95% CI [-1.78, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.61, 95% CI [-36.89, 21.67], t(2008) = -0.51, p = 0.610; Std. beta = -1.52,
## 95% CI [-4.70, 1.67])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.95, 95% CI [-46.46, 6.55], t(2008) = -1.48, p = 0.140; Std. beta = -1.57,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -5.85, 95% CI [-17.63, 5.93], t(2008) = -0.97, p = 0.330; Std. beta = -0.58,
## 95% CI [-1.39, 0.23])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.70, 95% CI [36.00, 89.39], t(2008) = 4.61, p < .001; Std. beta = 4.23, 95%
## CI [2.43, 6.04])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -0.02, 95% CI [-19.11, 19.08], t(2008) = -1.62e-03, p = 0.999; Std. beta =
## -1.16, 95% CI [-3.56, 1.25])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-17.58, 4.04], t(2008) = -1.23, p = 0.219; Std. beta = -0.35,
## 95% CI [-1.13, 0.44])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.99, 95% CI [-14.85, 6.86], t(2008) = -0.72, p = 0.471; Std. beta = -0.18,
## 95% CI [-0.97, 0.61])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.16, 95% CI [-36.74, 12.41], t(2008) = -0.97, p = 0.332; Std. beta =
## -0.25, 95% CI [-1.80, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.53, 95% CI [-21.00, -4.06], t(2008) = -2.90, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.01, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.37, 95% CI [-38.51, -8.24], t(2008) = -3.03, p = 0.002; Std. beta = 0.50,
## 95% CI [-4.19, 5.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-8.54, 11.01], t(2008) = 0.25, p = 0.804; Std. beta = -0.20,
## 95% CI [-0.86, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 4.12, 95% CI [-13.46, 21.71], t(2008) = 0.46, p = 0.646; Std. beta = -0.28,
## 95% CI [-1.44, 0.88])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.94, 95% CI [-31.37, -0.50], t(2008) = -2.03, p = 0.043; Std. beta = -1.87,
## 95% CI [-4.32, 0.58])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 0.06, 95% CI [-25.99, 26.10], t(2008) = 4.43e-03, p = 0.996; Std. beta =
## -0.25, 95% CI [-1.86, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.76, 95% CI [-12.08, 10.56], t(2008) = -0.13, p = 0.896; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.99, 95% CI [-6.98, 18.97], t(2008) = 0.91, p = 0.365; Std. beta = 0.30, 95%
## CI [-0.61, 1.21])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-18.50, 8.47], t(2008) = -0.73, p = 0.466; Std. beta = -0.87,
## 95% CI [-1.88, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.84, 95% CI [-14.52, 4.85], t(2008) = -0.98, p = 0.327; Std. beta = -0.23,
## 95% CI [-0.89, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.76, 95% CI [-28.98, 1.47], t(2008) = -1.77, p = 0.077; Std. beta = -0.04,
## 95% CI [-1.10, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.98, 95% CI [-8.61, 14.56], t(2008) = 0.50, p = 0.614; Std. beta = 0.70, 95%
## CI [-0.11, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.40, 95% CI [-12.34, 13.15], t(2008) = 0.06, p = 0.951; Std. beta = -0.09,
## 95% CI [-0.93, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.05, 95% CI [-9.63, 7.54], t(2008) = -0.24, p = 0.811; Std. beta = -0.26,
## 95% CI [-0.83, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.77, 95% CI [-13.46, 39.00], t(2008) = 0.96, p = 0.340; Std. beta = -2.01,
## 95% CI [-4.12, 0.09])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.58, 95% CI [-16.51, 19.66], t(2008) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.04, 1.54])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.75, 95% CI [-27.86, 2.37], t(2008) = -1.65, p = 0.098; Std. beta = -0.48,
## 95% CI [-1.80, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.77, 95% CI [-18.31, -1.23], t(2008) = -2.24, p = 0.025; Std. beta = -1.00,
## 95% CI [-2.04, 0.04])
## - The effect of time firstPFT × SS 5yrPreDx is statistically non-significant
## and positive (beta = 3.61, 95% CI [-1.66, 8.88], t(2008) = 1.34, p = 0.179;
## Std. beta = 0.07, 95% CI [-0.03, 0.18])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.43, 95% CI [-0.73, 3.59], t(2008) = 1.30, p = 0.194; Std.
## beta = 0.04, 95% CI [-0.02, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.69, 95% CI [-2.88, 1.50], t(2008) =
## -0.62, p = 0.535; Std. beta = -0.07, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.54, 95% CI [-0.76, 1.84], t(2008) = 0.82, p = 0.412; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.03, 95% CI [-0.10, 0.04], t(2008) = -0.91, p = 0.361; Std.
## beta = -0.03, 95% CI [-0.10, 0.04])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.77, 95% CI [-2.08, 0.54], t(2008) =
## -1.15, p = 0.251; Std. beta = -0.08, 95% CI [-0.22, 0.06])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.12, 95% CI [-17.96, 5.72], t(2008) =
## -1.01, p = 0.311; Std. beta = -0.66, 95% CI [-1.93, 0.62])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.13, 95% CI [-1.14, 5.39], t(2008) =
## 1.28, p = 0.202; Std. beta = 0.23, 95% CI [-0.12, 0.58])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -41.06, 95% CI [-79.27, -2.86], t(2008) = -2.11, p = 0.035;
## Std. beta = -4.42, 95% CI [-8.53, -0.31])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.40, 11.03], t(2008) = -0.12, p = 0.908;
## Std. beta = -0.07, 95% CI [-1.34, 1.19])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.44, 95% CI [-14.75, 9.88], t(2008) = -0.39, p = 0.698; Std.
## beta = -0.26, 95% CI [-1.59, 1.06])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-17.80, 11.89], t(2008) = -0.39, p = 0.696;
## Std. beta = -0.32, 95% CI [-1.92, 1.28])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-4.94, 0.72], t(2008) = -1.46, p = 0.144; Std.
## beta = -0.23, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-7.03, 9.68], t(2008) = 0.31, p = 0.756; Std.
## beta = 0.14, 95% CI [-0.76, 1.04])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-2.86, 1.36], t(2008) = -0.70, p = 0.484; Std.
## beta = -0.08, 95% CI [-0.31, 0.15])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.46, 95% CI [-4.81, 3.89], t(2008) = -0.21, p = 0.834; Std.
## beta = -0.05, 95% CI [-0.52, 0.42])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.27, 95% CI [-0.75, 3.28], t(2008) = 1.23, p = 0.218; Std.
## beta = 0.14, 95% CI [-0.08, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.80, 95% CI [-5.60, 9.20], t(2008) = 0.48, p = 0.634; Std.
## beta = 0.19, 95% CI [-0.60, 0.99])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.06, 95% CI [-2.18, 2.05], t(2008) = -0.06, p = 0.953; Std.
## beta = -6.80e-03, 95% CI [-0.23, 0.22])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-1.37, 5.07], t(2008) = 1.12, p = 0.261; Std.
## beta = 0.20, 95% CI [-0.15, 0.55])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.75, 95% CI [-28.76, 3.26], t(2008) = -1.56, p = 0.119;
## Std. beta = -1.37, 95% CI [-3.10, 0.35])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.20, 95% CI [-1.88, 12.27], t(2008) = 1.44, p = 0.150; Std.
## beta = 0.56, 95% CI [-0.20, 1.32])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-0.33, 10.94], t(2008) = 1.85, p = 0.065; Std.
## beta = 0.57, 95% CI [-0.04, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.06, 95% CI [-5.82, 9.94], t(2008) = 0.51, p = 0.609; Std.
## beta = 0.22, 95% CI [-0.63, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.58, 95% CI [-8.35, 7.19], t(2008) = -0.15, p = 0.883; Std.
## beta = -0.06, 95% CI [-0.90, 0.77])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.31, 95% CI [-56.77, 36.15], t(2008) = -0.44, p = 0.664;
## Std. beta = -1.11, 95% CI [-6.11, 3.89])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-30.02, 25.53], t(2008) = -0.16, p = 0.874;
## Std. beta = -0.24, 95% CI [-3.23, 2.75])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.90, 95% CI [-7.19, 3.38], t(2008) = -0.71, p = 0.480; Std.
## beta = -0.20, 95% CI [-0.77, 0.36])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.88, 95% CI [-37.39, 13.63], t(2008) = -0.91, p = 0.361;
## Std. beta = -1.28, 95% CI [-4.03, 1.47])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 1.12, 95% CI [-5.35, 7.59], t(2008) = 0.34, p = 0.734; Std.
## beta = 0.12, 95% CI [-0.58, 0.82])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.78, 7.69], t(2008) = 0.28, p = 0.781; Std.
## beta = 0.10, 95% CI [-0.62, 0.83])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.91, 95% CI [-3.41, 15.23], t(2008) = 1.24, p = 0.214; Std.
## beta = 0.64, 95% CI [-0.37, 1.64])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-0.78, 10.47], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.52, 95% CI [-0.08, 1.13])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.37, 95% CI [-31.12, 73.85], t(2008) = 0.80, p = 0.425; Std.
## beta = 2.30, 95% CI [-3.35, 7.95])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.91, 95% CI [-7.79, 1.96], t(2008) = -1.17, p = 0.241; Std.
## beta = -0.31, 95% CI [-0.84, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.77, 95% CI [-14.33, 2.79], t(2008) = -1.32, p = 0.187; Std.
## beta = -0.62, 95% CI [-1.54, 0.30])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.18, 95% CI [-33.95, 17.60], t(2008) = -0.62, p = 0.534;
## Std. beta = -0.88, 95% CI [-3.65, 1.89])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.83, 7.51], t(2008) = -0.51, p = 0.608; Std.
## beta = -0.29, 95% CI [-1.38, 0.81])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.11, 95% CI [-1.81, 6.03], t(2008) = 1.05, p = 0.292; Std.
## beta = 0.23, 95% CI [-0.20, 0.65])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.11, 5.95], t(2008) = -0.30, p = 0.763; Std.
## beta = -0.12, 95% CI [-0.87, 0.64])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -5.46, 95% CI [-13.29, 2.38], t(2008) = -1.37, p = 0.172; Std.
## beta = -0.59, 95% CI [-1.43, 0.26])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.69, 5.72], t(2008) = 0.42, p = 0.673; Std.
## beta = 0.11, 95% CI [-0.40, 0.62])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.19, 95% CI [0.09, 18.29], t(2008) = 1.98, p = 0.048; Std.
## beta = 0.99, 95% CI [9.95e-03, 1.97])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.18, 95% CI [-0.64, 11.00], t(2008) = 1.75, p = 0.081; Std.
## beta = 0.56, 95% CI [-0.07, 1.18])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.00, 4.54], t(2008) = -0.42, p = 0.676; Std.
## beta = -0.13, 95% CI [-0.75, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-5.69, 1.75], t(2008) = -1.04, p = 0.299; Std.
## beta = -0.21, 95% CI [-0.61, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.56, 95% CI [-50.17, -8.94], t(2008) = -2.81, p = 0.005;
## Std. beta = -3.18, 95% CI [-5.40, -0.96])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-7.55, 10.55], t(2008) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.88, 95% CI [-9.23, 16.99], t(2008) = 0.58, p = 0.562; Std.
## beta = 0.42, 95% CI [-0.99, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.49, 95% CI [-15.15, 8.17], t(2008) = -0.59, p = 0.557; Std.
## beta = -0.38, 95% CI [-1.63, 0.88])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*Soil_5yrPreDx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14848.7
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1442 -0.4928 -0.0109 0.4393 7.1034
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 143.82 11.993
## time_firstPFT 10.85 3.294 -0.30
## Residual 41.75 6.462
## Number of obs: 2134, groups: ID, 460
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 42.8999 2.5831 16.608
## time_firstPFT -6.4890 1.3046 -4.974
## Soil_5yrPreDx -4.8521 4.6805 -1.037
## site02R -2.4959 13.6130 -0.183
## site03R 27.0092 10.0248 2.694
## site04R -5.5404 9.2843 -0.597
## site05R -12.7995 7.7764 -1.646
## site06R 5.7422 9.7218 0.591
## site07R 4.9293 3.7557 1.312
## site09R -9.4499 9.4928 -0.995
## site101 19.4703 2.6382 7.380
## site102 8.5592 4.9706 1.722
## site103 -2.8295 2.4537 -1.153
## site104 -10.8351 5.3990 -2.007
## site105 0.8825 2.6499 0.333
## site106 -3.8685 3.3806 -1.144
## site107 9.7947 9.6501 1.015
## site108 -8.1884 7.5309 -1.087
## site10R -2.2976 13.7635 -0.167
## site11R 4.2160 6.5256 0.646
## site12R -8.8410 9.3533 -0.945
## site13R -10.5186 7.3420 -1.433
## site14R -7.8340 15.0543 -0.520
## site15R -22.9325 13.6613 -1.679
## site16R -8.7362 5.9167 -1.477
## site17R 60.1526 13.6716 4.400
## site18R -2.9297 9.7959 -0.299
## site19R -1.0930 7.0441 -0.155
## site20R -1.4720 5.6759 -0.259
## site21R -11.9032 12.7520 -0.933
## site22R -12.0921 4.4219 -2.735
## site23R -15.3850 6.7967 -2.264
## site24R 2.2539 5.0388 0.447
## site25R -6.3538 5.5816 -1.138
## site28R -17.1325 7.9221 -2.163
## site29R -0.5349 13.3969 -0.040
## site31R -0.3562 5.8295 -0.061
## site32R 13.4515 10.1164 1.330
## site33R -4.5501 7.4865 -0.608
## site34R -5.4491 5.0846 -1.072
## site35R -13.9840 7.8989 -1.770
## site36R 3.8472 5.9588 0.646
## site37R 1.5156 6.5404 0.232
## site38R -1.8803 4.4596 -0.422
## site39R 7.9065 13.3215 0.594
## site40R 3.2656 9.3997 0.347
## site41R -13.6023 7.7369 -1.758
## site42R -9.2713 4.4119 -2.101
## time_firstPFT:Soil_5yrPreDx 4.0153 2.3100 1.738
## time_firstPFT:site02R -34.1945 18.5246 -1.846
## time_firstPFT:site03R -2.7940 6.0024 -0.465
## time_firstPFT:site04R -1.4442 6.2429 -0.231
## time_firstPFT:site05R -3.2947 7.5441 -0.437
## time_firstPFT:site06R 2.4463 5.0336 0.486
## time_firstPFT:site07R -2.0764 1.4406 -1.441
## time_firstPFT:site09R 1.6154 4.2031 0.384
## time_firstPFT:site101 -0.2694 1.1405 -0.236
## time_firstPFT:site102 -1.2251 2.1662 -0.566
## time_firstPFT:site103 2.2028 1.1028 1.997
## time_firstPFT:site104 3.5289 3.7672 0.937
## time_firstPFT:site105 0.5982 1.1676 0.512
## time_firstPFT:site106 1.7210 1.6155 1.065
## time_firstPFT:site107 -12.6767 8.1588 -1.554
## time_firstPFT:site108 4.3624 3.3801 1.291
## time_firstPFT:site11R 4.0155 2.8453 1.411
## time_firstPFT:site12R 1.6678 3.9800 0.419
## time_firstPFT:site13R 0.1513 3.9428 0.038
## time_firstPFT:site14R -9.7375 23.6911 -0.411
## time_firstPFT:site15R -2.3085 14.1394 -0.163
## time_firstPFT:site16R -0.5283 2.6359 -0.200
## time_firstPFT:site18R -12.2270 12.9977 -0.941
## time_firstPFT:site19R -3.1117 3.9196 -0.794
## time_firstPFT:site20R -0.1322 3.4182 -0.039
## time_firstPFT:site21R 4.9121 4.7279 1.039
## time_firstPFT:site22R 5.2835 2.8220 1.872
## time_firstPFT:site23R -3.7689 5.5603 -0.678
## time_firstPFT:site24R -3.2943 2.4640 -1.337
## time_firstPFT:site25R -1.5993 2.9745 -0.538
## time_firstPFT:site28R -9.1219 13.0673 -0.698
## time_firstPFT:site29R -1.8355 5.0999 -0.360
## time_firstPFT:site31R 1.8291 1.9774 0.925
## time_firstPFT:site32R -8.5872 5.4982 -1.562
## time_firstPFT:site33R -6.3772 4.0823 -1.562
## time_firstPFT:site34R 1.5284 2.3916 0.639
## time_firstPFT:site35R 8.8897 4.5963 1.934
## time_firstPFT:site36R 4.9050 2.9319 1.673
## time_firstPFT:site37R -1.0573 2.8480 -0.371
## time_firstPFT:site38R -1.6398 1.9037 -0.861
## time_firstPFT:site39R -31.1092 10.4169 -2.986
## time_firstPFT:site40R 1.2026 4.5487 0.264
## time_firstPFT:site41R 3.9979 6.6492 0.601
## time_firstPFT:site42R -2.1960 5.9452 -0.369##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.792
## Unadjusted ICC: 0.540report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## Soil_5yrPreDx + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.86) and the part
## related to the fixed effects alone (marginal R2) is of 0.32. The model's
## intercept, corresponding to time_firstPFT = 0, is at 42.90 (95% CI [37.83,
## 47.97], t(2038) = 16.61, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.49, 95% CI [-9.05, -3.93], t(2038) = -4.97, p < .001; Std. beta = -0.50, 95%
## CI [-0.60, -0.40])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -4.85, 95% CI [-14.03, 4.33], t(2038) = -1.04, p = 0.300; Std. beta =
## 0.02, 95% CI [-0.15, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-29.19, 24.20], t(2038) = -0.18, p = 0.855; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.01, 95% CI [7.35, 46.67], t(2038) = 2.69, p = 0.007; Std. beta = 1.56, 95%
## CI [0.29, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-23.75, 12.67], t(2038) = -0.60, p = 0.551; Std. beta = -0.51,
## 95% CI [-1.91, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-28.05, 2.45], t(2038) = -1.65, p = 0.100; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-13.32, 24.81], t(2038) = 0.59, p = 0.555; Std. beta = 0.63,
## 95% CI [-0.71, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-2.44, 12.29], t(2038) = 1.31, p = 0.190; Std. beta = 0.13, 95%
## CI [-0.34, 0.60])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-28.07, 9.17], t(2038) = -1.00, p = 0.320; Std. beta = -0.48,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.30, 24.64], t(2038) = 7.38, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.56, 95% CI [-1.19, 18.31], t(2038) = 1.72, p = 0.085; Std. beta = 0.46, 95%
## CI [-0.17, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.83, 95% CI [-7.64, 1.98], t(2038) = -1.15, p = 0.249; Std. beta = 0.02,
## 95% CI [-0.30, 0.35])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.84, 95% CI [-21.42, -0.25], t(2038) = -2.01, p = 0.045; Std. beta = -0.39,
## 95% CI [-1.24, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-4.31, 6.08], t(2038) = 0.33, p = 0.739; Std. beta = 0.12, 95%
## CI [-0.23, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-10.50, 2.76], t(2038) = -1.14, p = 0.253; Std. beta = -0.09,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.79, 95% CI [-9.13, 28.72], t(2038) = 1.01, p = 0.310; Std. beta = -0.57,
## 95% CI [-2.13, 1.00])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-22.96, 6.58], t(2038) = -1.09, p = 0.277; Std. beta = -0.13,
## 95% CI [-1.08, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-29.29, 24.69], t(2038) = -0.17, p = 0.867; Std. beta = -0.16,
## 95% CI [-1.98, 1.67])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 4.22, 95% CI [-8.58, 17.01], t(2038) = 0.65, p = 0.518; Std. beta = 0.67, 95%
## CI [-0.18, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-27.18, 9.50], t(2038) = -0.95, p = 0.345; Std. beta = -0.44,
## 95% CI [-1.68, 0.81])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-24.92, 3.88], t(2038) = -1.43, p = 0.152; Std. beta = -0.70,
## 95% CI [-1.63, 0.24])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-37.36, 21.69], t(2038) = -0.52, p = 0.603; Std. beta = -1.47,
## 95% CI [-4.65, 1.70])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.93, 95% CI [-49.72, 3.86], t(2038) = -1.68, p = 0.093; Std. beta = -1.77,
## 95% CI [-4.27, 0.72])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.34, 2.87], t(2038) = -1.48, p = 0.140; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.15, 95% CI [33.34, 86.96], t(2038) = 4.40, p < .001; Std. beta = 4.07, 95%
## CI [2.25, 5.88])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.14, 16.28], t(2038) = -0.30, p = 0.765; Std. beta = -1.38,
## 95% CI [-3.78, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.09, 95% CI [-14.91, 12.72], t(2038) = -0.16, p = 0.877; Std. beta = -0.38,
## 95% CI [-1.36, 0.61])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.47, 95% CI [-12.60, 9.66], t(2038) = -0.26, p = 0.795; Std. beta = -0.11,
## 95% CI [-0.91, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-36.91, 13.11], t(2038) = -0.93, p = 0.351; Std. beta =
## -0.33, 95% CI [-1.90, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.09, 95% CI [-20.76, -3.42], t(2038) = -2.73, p = 0.006; Std. beta = -0.31,
## 95% CI [-0.94, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.39, 95% CI [-28.71, -2.06], t(2038) = -2.26, p = 0.024; Std. beta = -1.41,
## 95% CI [-2.58, -0.23])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-7.63, 12.14], t(2038) = 0.45, p = 0.655; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.35, 95% CI [-17.30, 4.59], t(2038) = -1.14, p = 0.255; Std. beta = -0.58,
## 95% CI [-1.32, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.13, 95% CI [-32.67, -1.60], t(2038) = -2.16, p = 0.031; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.53, 95% CI [-26.81, 25.74], t(2038) = -0.04, p = 0.968; Std. beta = -0.21,
## 95% CI [-1.82, 1.39])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-11.79, 11.08], t(2038) = -0.06, p = 0.951; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 13.45, 95% CI [-6.39, 33.29], t(2038) = 1.33, p = 0.184; Std. beta = 0.08,
## 95% CI [-1.35, 1.50])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.55, 95% CI [-19.23, 10.13], t(2038) = -0.61, p = 0.543; Std. beta = -0.93,
## 95% CI [-1.99, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.42, 4.52], t(2038) = -1.07, p = 0.284; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-29.47, 1.51], t(2038) = -1.77, p = 0.077; Std. beta = -0.08,
## 95% CI [-1.15, 0.99])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-7.84, 15.53], t(2038) = 0.65, p = 0.519; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.31, 14.34], t(2038) = 0.23, p = 0.817; Std. beta =
## -3.63e-05, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-10.63, 6.87], t(2038) = -0.42, p = 0.673; Std. beta = -0.29,
## 95% CI [-0.85, 0.28])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.91, 95% CI [-18.22, 34.03], t(2038) = 0.59, p = 0.553; Std. beta = -2.48,
## 95% CI [-4.56, -0.40])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-15.17, 21.70], t(2038) = 0.35, p = 0.728; Std. beta = 0.34,
## 95% CI [-0.96, 1.63])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.60, 95% CI [-28.78, 1.57], t(2038) = -1.76, p = 0.079; Std. beta = -0.53,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.27, 95% CI [-17.92, -0.62], t(2038) = -2.10, p = 0.036; Std. beta = -0.84,
## 95% CI [-1.87, 0.19])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 4.02, 95% CI [-0.51, 8.55], t(2038) = 1.74, p = 0.082;
## Std. beta = 0.12, 95% CI [-0.01, 0.25])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.19, 95% CI [-70.52, 2.13], t(2038) = -1.85, p = 0.065;
## Std. beta = -3.68, 95% CI [-7.58, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-14.57, 8.98], t(2038) = -0.47, p = 0.642; Std.
## beta = -0.30, 95% CI [-1.57, 0.97])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-13.69, 10.80], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.47, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.09, 11.50], t(2038) = -0.44, p = 0.662;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-7.43, 12.32], t(2038) = 0.49, p = 0.627; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-4.90, 0.75], t(2038) = -1.44, p = 0.150; Std.
## beta = -0.22, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-6.63, 9.86], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.17, 95% CI [-0.71, 1.06])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-2.51, 1.97], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.03, 95% CI [-0.27, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-5.47, 3.02], t(2038) = -0.57, p = 0.572; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.20, 95% CI [0.04, 4.37], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.24, 95% CI [4.31e-03, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-3.86, 10.92], t(2038) = 0.94, p = 0.349; Std.
## beta = 0.38, 95% CI [-0.41, 1.17])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-1.69, 2.89], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.06, 95% CI [-0.18, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-1.45, 4.89], t(2038) = 1.07, p = 0.287; Std.
## beta = 0.19, 95% CI [-0.16, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.68, 95% CI [-28.68, 3.32], t(2038) = -1.55, p = 0.120;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-2.27, 10.99], t(2038) = 1.29, p = 0.197; Std.
## beta = 0.47, 95% CI [-0.24, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.02, 95% CI [-1.56, 9.60], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.43, 95% CI [-0.17, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-6.14, 9.47], t(2038) = 0.42, p = 0.675; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-7.58, 7.88], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.82, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.74, 95% CI [-56.20, 36.72], t(2038) = -0.41, p = 0.681;
## Std. beta = -1.05, 95% CI [-6.04, 3.95])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-30.04, 25.42], t(2038) = -0.16, p = 0.870;
## Std. beta = -0.25, 95% CI [-3.23, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-5.70, 4.64], t(2038) = -0.20, p = 0.841; Std.
## beta = -0.06, 95% CI [-0.61, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-37.72, 13.26], t(2038) = -0.94, p = 0.347;
## Std. beta = -1.31, 95% CI [-4.05, 1.43])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.80, 4.58], t(2038) = -0.79, p = 0.427; Std.
## beta = -0.33, 95% CI [-1.16, 0.49])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-6.84, 6.57], t(2038) = -0.04, p = 0.969; Std.
## beta = -0.01, 95% CI [-0.73, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-4.36, 14.18], t(2038) = 1.04, p = 0.299; Std.
## beta = 0.53, 95% CI [-0.47, 1.52])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.28, 95% CI [-0.25, 10.82], t(2038) = 1.87, p = 0.061; Std.
## beta = 0.57, 95% CI [-0.03, 1.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -3.77, 95% CI [-14.67, 7.14], t(2038) = -0.68, p = 0.498; Std.
## beta = -0.41, 95% CI [-1.58, 0.77])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-8.13, 1.54], t(2038) = -1.34, p = 0.181; Std.
## beta = -0.35, 95% CI [-0.87, 0.17])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.43, 4.23], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.80, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.12, 95% CI [-34.75, 16.50], t(2038) = -0.70, p = 0.485;
## Std. beta = -0.98, 95% CI [-3.74, 1.77])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-11.84, 8.17], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.20, 95% CI [-1.27, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-2.05, 5.71], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.20, 95% CI [-0.22, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -8.59, 95% CI [-19.37, 2.20], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.92, 95% CI [-2.08, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.38, 95% CI [-14.38, 1.63], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.69, 95% CI [-1.55, 0.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.53, 95% CI [-3.16, 6.22], t(2038) = 0.64, p = 0.523; Std.
## beta = 0.16, 95% CI [-0.34, 0.67])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.89, 95% CI [-0.12, 17.90], t(2038) = 1.93, p = 0.053; Std.
## beta = 0.96, 95% CI [-0.01, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.84, 10.65], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.15])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.64, 4.53], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.11, 95% CI [-0.71, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-5.37, 2.09], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.18, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -31.11, 95% CI [-51.54, -10.68], t(2038) = -2.99, p = 0.003;
## Std. beta = -3.34, 95% CI [-5.54, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-7.72, 10.12], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.13, 95% CI [-0.83, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-9.04, 17.04], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.43, 95% CI [-0.97, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-13.86, 9.46], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.24, 95% CI [-1.49, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## Soil_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to Soil_5yrPreDx = 0, is at 42.90 (95% CI [37.83, 47.97], t(2038)
## = 16.61, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.49, 95% CI [-9.05, -3.93], t(2038) = -4.97, p < .001; Std. beta = -0.50, 95%
## CI [-0.60, -0.40])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -4.85, 95% CI [-14.03, 4.33], t(2038) = -1.04, p = 0.300; Std. beta =
## 0.02, 95% CI [-0.15, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-29.19, 24.20], t(2038) = -0.18, p = 0.855; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.01, 95% CI [7.35, 46.67], t(2038) = 2.69, p = 0.007; Std. beta = 1.56, 95%
## CI [0.29, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-23.75, 12.67], t(2038) = -0.60, p = 0.551; Std. beta = -0.51,
## 95% CI [-1.91, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-28.05, 2.45], t(2038) = -1.65, p = 0.100; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-13.32, 24.81], t(2038) = 0.59, p = 0.555; Std. beta = 0.63,
## 95% CI [-0.71, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-2.44, 12.29], t(2038) = 1.31, p = 0.190; Std. beta = 0.13, 95%
## CI [-0.34, 0.60])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-28.07, 9.17], t(2038) = -1.00, p = 0.320; Std. beta = -0.48,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.30, 24.64], t(2038) = 7.38, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.56, 95% CI [-1.19, 18.31], t(2038) = 1.72, p = 0.085; Std. beta = 0.46, 95%
## CI [-0.17, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.83, 95% CI [-7.64, 1.98], t(2038) = -1.15, p = 0.249; Std. beta = 0.02,
## 95% CI [-0.30, 0.35])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.84, 95% CI [-21.42, -0.25], t(2038) = -2.01, p = 0.045; Std. beta = -0.39,
## 95% CI [-1.24, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-4.31, 6.08], t(2038) = 0.33, p = 0.739; Std. beta = 0.12, 95%
## CI [-0.23, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-10.50, 2.76], t(2038) = -1.14, p = 0.253; Std. beta = -0.09,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.79, 95% CI [-9.13, 28.72], t(2038) = 1.01, p = 0.310; Std. beta = -0.57,
## 95% CI [-2.13, 1.00])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-22.96, 6.58], t(2038) = -1.09, p = 0.277; Std. beta = -0.13,
## 95% CI [-1.08, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-29.29, 24.69], t(2038) = -0.17, p = 0.867; Std. beta = -0.16,
## 95% CI [-1.98, 1.67])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 4.22, 95% CI [-8.58, 17.01], t(2038) = 0.65, p = 0.518; Std. beta = 0.67, 95%
## CI [-0.18, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-27.18, 9.50], t(2038) = -0.95, p = 0.345; Std. beta = -0.44,
## 95% CI [-1.68, 0.81])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-24.92, 3.88], t(2038) = -1.43, p = 0.152; Std. beta = -0.70,
## 95% CI [-1.63, 0.24])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-37.36, 21.69], t(2038) = -0.52, p = 0.603; Std. beta = -1.47,
## 95% CI [-4.65, 1.70])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.93, 95% CI [-49.72, 3.86], t(2038) = -1.68, p = 0.093; Std. beta = -1.77,
## 95% CI [-4.27, 0.72])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.34, 2.87], t(2038) = -1.48, p = 0.140; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.15, 95% CI [33.34, 86.96], t(2038) = 4.40, p < .001; Std. beta = 4.07, 95%
## CI [2.25, 5.88])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.14, 16.28], t(2038) = -0.30, p = 0.765; Std. beta = -1.38,
## 95% CI [-3.78, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.09, 95% CI [-14.91, 12.72], t(2038) = -0.16, p = 0.877; Std. beta = -0.38,
## 95% CI [-1.36, 0.61])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.47, 95% CI [-12.60, 9.66], t(2038) = -0.26, p = 0.795; Std. beta = -0.11,
## 95% CI [-0.91, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-36.91, 13.11], t(2038) = -0.93, p = 0.351; Std. beta =
## -0.33, 95% CI [-1.90, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.09, 95% CI [-20.76, -3.42], t(2038) = -2.73, p = 0.006; Std. beta = -0.31,
## 95% CI [-0.94, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.39, 95% CI [-28.71, -2.06], t(2038) = -2.26, p = 0.024; Std. beta = -1.41,
## 95% CI [-2.58, -0.23])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-7.63, 12.14], t(2038) = 0.45, p = 0.655; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.35, 95% CI [-17.30, 4.59], t(2038) = -1.14, p = 0.255; Std. beta = -0.58,
## 95% CI [-1.32, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.13, 95% CI [-32.67, -1.60], t(2038) = -2.16, p = 0.031; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.53, 95% CI [-26.81, 25.74], t(2038) = -0.04, p = 0.968; Std. beta = -0.21,
## 95% CI [-1.82, 1.39])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-11.79, 11.08], t(2038) = -0.06, p = 0.951; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 13.45, 95% CI [-6.39, 33.29], t(2038) = 1.33, p = 0.184; Std. beta = 0.08,
## 95% CI [-1.35, 1.50])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.55, 95% CI [-19.23, 10.13], t(2038) = -0.61, p = 0.543; Std. beta = -0.93,
## 95% CI [-1.99, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.42, 4.52], t(2038) = -1.07, p = 0.284; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-29.47, 1.51], t(2038) = -1.77, p = 0.077; Std. beta = -0.08,
## 95% CI [-1.15, 0.99])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-7.84, 15.53], t(2038) = 0.65, p = 0.519; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.31, 14.34], t(2038) = 0.23, p = 0.817; Std. beta =
## -3.63e-05, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-10.63, 6.87], t(2038) = -0.42, p = 0.673; Std. beta = -0.29,
## 95% CI [-0.85, 0.28])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.91, 95% CI [-18.22, 34.03], t(2038) = 0.59, p = 0.553; Std. beta = -2.48,
## 95% CI [-4.56, -0.40])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-15.17, 21.70], t(2038) = 0.35, p = 0.728; Std. beta = 0.34,
## 95% CI [-0.96, 1.63])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.60, 95% CI [-28.78, 1.57], t(2038) = -1.76, p = 0.079; Std. beta = -0.53,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.27, 95% CI [-17.92, -0.62], t(2038) = -2.10, p = 0.036; Std. beta = -0.84,
## 95% CI [-1.87, 0.19])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 4.02, 95% CI [-0.51, 8.55], t(2038) = 1.74, p = 0.082;
## Std. beta = 0.12, 95% CI [-0.01, 0.25])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.19, 95% CI [-70.52, 2.13], t(2038) = -1.85, p = 0.065;
## Std. beta = -3.68, 95% CI [-7.58, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-14.57, 8.98], t(2038) = -0.47, p = 0.642; Std.
## beta = -0.30, 95% CI [-1.57, 0.97])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-13.69, 10.80], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.47, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.09, 11.50], t(2038) = -0.44, p = 0.662;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-7.43, 12.32], t(2038) = 0.49, p = 0.627; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-4.90, 0.75], t(2038) = -1.44, p = 0.150; Std.
## beta = -0.22, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-6.63, 9.86], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.17, 95% CI [-0.71, 1.06])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-2.51, 1.97], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.03, 95% CI [-0.27, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-5.47, 3.02], t(2038) = -0.57, p = 0.572; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.20, 95% CI [0.04, 4.37], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.24, 95% CI [4.31e-03, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-3.86, 10.92], t(2038) = 0.94, p = 0.349; Std.
## beta = 0.38, 95% CI [-0.41, 1.17])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-1.69, 2.89], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.06, 95% CI [-0.18, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-1.45, 4.89], t(2038) = 1.07, p = 0.287; Std.
## beta = 0.19, 95% CI [-0.16, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.68, 95% CI [-28.68, 3.32], t(2038) = -1.55, p = 0.120;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-2.27, 10.99], t(2038) = 1.29, p = 0.197; Std.
## beta = 0.47, 95% CI [-0.24, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.02, 95% CI [-1.56, 9.60], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.43, 95% CI [-0.17, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-6.14, 9.47], t(2038) = 0.42, p = 0.675; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-7.58, 7.88], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.82, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.74, 95% CI [-56.20, 36.72], t(2038) = -0.41, p = 0.681;
## Std. beta = -1.05, 95% CI [-6.04, 3.95])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-30.04, 25.42], t(2038) = -0.16, p = 0.870;
## Std. beta = -0.25, 95% CI [-3.23, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-5.70, 4.64], t(2038) = -0.20, p = 0.841; Std.
## beta = -0.06, 95% CI [-0.61, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-37.72, 13.26], t(2038) = -0.94, p = 0.347;
## Std. beta = -1.31, 95% CI [-4.05, 1.43])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.80, 4.58], t(2038) = -0.79, p = 0.427; Std.
## beta = -0.33, 95% CI [-1.16, 0.49])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-6.84, 6.57], t(2038) = -0.04, p = 0.969; Std.
## beta = -0.01, 95% CI [-0.73, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-4.36, 14.18], t(2038) = 1.04, p = 0.299; Std.
## beta = 0.53, 95% CI [-0.47, 1.52])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.28, 95% CI [-0.25, 10.82], t(2038) = 1.87, p = 0.061; Std.
## beta = 0.57, 95% CI [-0.03, 1.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -3.77, 95% CI [-14.67, 7.14], t(2038) = -0.68, p = 0.498; Std.
## beta = -0.41, 95% CI [-1.58, 0.77])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-8.13, 1.54], t(2038) = -1.34, p = 0.181; Std.
## beta = -0.35, 95% CI [-0.87, 0.17])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.43, 4.23], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.80, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.12, 95% CI [-34.75, 16.50], t(2038) = -0.70, p = 0.485;
## Std. beta = -0.98, 95% CI [-3.74, 1.77])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-11.84, 8.17], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.20, 95% CI [-1.27, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-2.05, 5.71], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.20, 95% CI [-0.22, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -8.59, 95% CI [-19.37, 2.20], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.92, 95% CI [-2.08, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.38, 95% CI [-14.38, 1.63], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.69, 95% CI [-1.55, 0.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.53, 95% CI [-3.16, 6.22], t(2038) = 0.64, p = 0.523; Std.
## beta = 0.16, 95% CI [-0.34, 0.67])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.89, 95% CI [-0.12, 17.90], t(2038) = 1.93, p = 0.053; Std.
## beta = 0.96, 95% CI [-0.01, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.84, 10.65], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.15])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.64, 4.53], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.11, 95% CI [-0.71, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-5.37, 2.09], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.18, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -31.11, 95% CI [-51.54, -10.68], t(2038) = -2.99, p = 0.003;
## Std. beta = -3.34, 95% CI [-5.54, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-7.72, 10.12], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.13, 95% CI [-0.83, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-9.04, 17.04], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.43, 95% CI [-0.97, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-13.86, 9.46], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.24, 95% CI [-1.49, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.86) and the part related to the fixed effects
## alone (marginal R2) is of 0.32. The model's intercept, corresponding to site =
## Simmons, is at 42.90 (95% CI [37.83, 47.97], t(2038) = 16.61, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.49, 95% CI [-9.05, -3.93], t(2038) = -4.97, p < .001; Std. beta = -0.50, 95%
## CI [-0.60, -0.40])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -4.85, 95% CI [-14.03, 4.33], t(2038) = -1.04, p = 0.300; Std. beta =
## 0.02, 95% CI [-0.15, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-29.19, 24.20], t(2038) = -0.18, p = 0.855; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.01, 95% CI [7.35, 46.67], t(2038) = 2.69, p = 0.007; Std. beta = 1.56, 95%
## CI [0.29, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-23.75, 12.67], t(2038) = -0.60, p = 0.551; Std. beta = -0.51,
## 95% CI [-1.91, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-28.05, 2.45], t(2038) = -1.65, p = 0.100; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-13.32, 24.81], t(2038) = 0.59, p = 0.555; Std. beta = 0.63,
## 95% CI [-0.71, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-2.44, 12.29], t(2038) = 1.31, p = 0.190; Std. beta = 0.13, 95%
## CI [-0.34, 0.60])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-28.07, 9.17], t(2038) = -1.00, p = 0.320; Std. beta = -0.48,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.30, 24.64], t(2038) = 7.38, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.56, 95% CI [-1.19, 18.31], t(2038) = 1.72, p = 0.085; Std. beta = 0.46, 95%
## CI [-0.17, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.83, 95% CI [-7.64, 1.98], t(2038) = -1.15, p = 0.249; Std. beta = 0.02,
## 95% CI [-0.30, 0.35])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.84, 95% CI [-21.42, -0.25], t(2038) = -2.01, p = 0.045; Std. beta = -0.39,
## 95% CI [-1.24, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-4.31, 6.08], t(2038) = 0.33, p = 0.739; Std. beta = 0.12, 95%
## CI [-0.23, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-10.50, 2.76], t(2038) = -1.14, p = 0.253; Std. beta = -0.09,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.79, 95% CI [-9.13, 28.72], t(2038) = 1.01, p = 0.310; Std. beta = -0.57,
## 95% CI [-2.13, 1.00])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-22.96, 6.58], t(2038) = -1.09, p = 0.277; Std. beta = -0.13,
## 95% CI [-1.08, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-29.29, 24.69], t(2038) = -0.17, p = 0.867; Std. beta = -0.16,
## 95% CI [-1.98, 1.67])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 4.22, 95% CI [-8.58, 17.01], t(2038) = 0.65, p = 0.518; Std. beta = 0.67, 95%
## CI [-0.18, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-27.18, 9.50], t(2038) = -0.95, p = 0.345; Std. beta = -0.44,
## 95% CI [-1.68, 0.81])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-24.92, 3.88], t(2038) = -1.43, p = 0.152; Std. beta = -0.70,
## 95% CI [-1.63, 0.24])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-37.36, 21.69], t(2038) = -0.52, p = 0.603; Std. beta = -1.47,
## 95% CI [-4.65, 1.70])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.93, 95% CI [-49.72, 3.86], t(2038) = -1.68, p = 0.093; Std. beta = -1.77,
## 95% CI [-4.27, 0.72])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.34, 2.87], t(2038) = -1.48, p = 0.140; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.15, 95% CI [33.34, 86.96], t(2038) = 4.40, p < .001; Std. beta = 4.07, 95%
## CI [2.25, 5.88])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.14, 16.28], t(2038) = -0.30, p = 0.765; Std. beta = -1.38,
## 95% CI [-3.78, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.09, 95% CI [-14.91, 12.72], t(2038) = -0.16, p = 0.877; Std. beta = -0.38,
## 95% CI [-1.36, 0.61])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.47, 95% CI [-12.60, 9.66], t(2038) = -0.26, p = 0.795; Std. beta = -0.11,
## 95% CI [-0.91, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-36.91, 13.11], t(2038) = -0.93, p = 0.351; Std. beta =
## -0.33, 95% CI [-1.90, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.09, 95% CI [-20.76, -3.42], t(2038) = -2.73, p = 0.006; Std. beta = -0.31,
## 95% CI [-0.94, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.39, 95% CI [-28.71, -2.06], t(2038) = -2.26, p = 0.024; Std. beta = -1.41,
## 95% CI [-2.58, -0.23])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-7.63, 12.14], t(2038) = 0.45, p = 0.655; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.35, 95% CI [-17.30, 4.59], t(2038) = -1.14, p = 0.255; Std. beta = -0.58,
## 95% CI [-1.32, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.13, 95% CI [-32.67, -1.60], t(2038) = -2.16, p = 0.031; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.53, 95% CI [-26.81, 25.74], t(2038) = -0.04, p = 0.968; Std. beta = -0.21,
## 95% CI [-1.82, 1.39])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-11.79, 11.08], t(2038) = -0.06, p = 0.951; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 13.45, 95% CI [-6.39, 33.29], t(2038) = 1.33, p = 0.184; Std. beta = 0.08,
## 95% CI [-1.35, 1.50])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.55, 95% CI [-19.23, 10.13], t(2038) = -0.61, p = 0.543; Std. beta = -0.93,
## 95% CI [-1.99, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.42, 4.52], t(2038) = -1.07, p = 0.284; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-29.47, 1.51], t(2038) = -1.77, p = 0.077; Std. beta = -0.08,
## 95% CI [-1.15, 0.99])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-7.84, 15.53], t(2038) = 0.65, p = 0.519; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.31, 14.34], t(2038) = 0.23, p = 0.817; Std. beta =
## -3.63e-05, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-10.63, 6.87], t(2038) = -0.42, p = 0.673; Std. beta = -0.29,
## 95% CI [-0.85, 0.28])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.91, 95% CI [-18.22, 34.03], t(2038) = 0.59, p = 0.553; Std. beta = -2.48,
## 95% CI [-4.56, -0.40])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-15.17, 21.70], t(2038) = 0.35, p = 0.728; Std. beta = 0.34,
## 95% CI [-0.96, 1.63])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.60, 95% CI [-28.78, 1.57], t(2038) = -1.76, p = 0.079; Std. beta = -0.53,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.27, 95% CI [-17.92, -0.62], t(2038) = -2.10, p = 0.036; Std. beta = -0.84,
## 95% CI [-1.87, 0.19])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 4.02, 95% CI [-0.51, 8.55], t(2038) = 1.74, p = 0.082;
## Std. beta = 0.12, 95% CI [-0.01, 0.25])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.19, 95% CI [-70.52, 2.13], t(2038) = -1.85, p = 0.065;
## Std. beta = -3.68, 95% CI [-7.58, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-14.57, 8.98], t(2038) = -0.47, p = 0.642; Std.
## beta = -0.30, 95% CI [-1.57, 0.97])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-13.69, 10.80], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.47, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.09, 11.50], t(2038) = -0.44, p = 0.662;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-7.43, 12.32], t(2038) = 0.49, p = 0.627; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-4.90, 0.75], t(2038) = -1.44, p = 0.150; Std.
## beta = -0.22, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-6.63, 9.86], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.17, 95% CI [-0.71, 1.06])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-2.51, 1.97], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.03, 95% CI [-0.27, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-5.47, 3.02], t(2038) = -0.57, p = 0.572; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.20, 95% CI [0.04, 4.37], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.24, 95% CI [4.31e-03, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-3.86, 10.92], t(2038) = 0.94, p = 0.349; Std.
## beta = 0.38, 95% CI [-0.41, 1.17])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-1.69, 2.89], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.06, 95% CI [-0.18, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-1.45, 4.89], t(2038) = 1.07, p = 0.287; Std.
## beta = 0.19, 95% CI [-0.16, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.68, 95% CI [-28.68, 3.32], t(2038) = -1.55, p = 0.120;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-2.27, 10.99], t(2038) = 1.29, p = 0.197; Std.
## beta = 0.47, 95% CI [-0.24, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.02, 95% CI [-1.56, 9.60], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.43, 95% CI [-0.17, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-6.14, 9.47], t(2038) = 0.42, p = 0.675; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-7.58, 7.88], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.82, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.74, 95% CI [-56.20, 36.72], t(2038) = -0.41, p = 0.681;
## Std. beta = -1.05, 95% CI [-6.04, 3.95])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-30.04, 25.42], t(2038) = -0.16, p = 0.870;
## Std. beta = -0.25, 95% CI [-3.23, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-5.70, 4.64], t(2038) = -0.20, p = 0.841; Std.
## beta = -0.06, 95% CI [-0.61, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-37.72, 13.26], t(2038) = -0.94, p = 0.347;
## Std. beta = -1.31, 95% CI [-4.05, 1.43])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.80, 4.58], t(2038) = -0.79, p = 0.427; Std.
## beta = -0.33, 95% CI [-1.16, 0.49])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-6.84, 6.57], t(2038) = -0.04, p = 0.969; Std.
## beta = -0.01, 95% CI [-0.73, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-4.36, 14.18], t(2038) = 1.04, p = 0.299; Std.
## beta = 0.53, 95% CI [-0.47, 1.52])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.28, 95% CI [-0.25, 10.82], t(2038) = 1.87, p = 0.061; Std.
## beta = 0.57, 95% CI [-0.03, 1.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -3.77, 95% CI [-14.67, 7.14], t(2038) = -0.68, p = 0.498; Std.
## beta = -0.41, 95% CI [-1.58, 0.77])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-8.13, 1.54], t(2038) = -1.34, p = 0.181; Std.
## beta = -0.35, 95% CI [-0.87, 0.17])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.43, 4.23], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.80, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.12, 95% CI [-34.75, 16.50], t(2038) = -0.70, p = 0.485;
## Std. beta = -0.98, 95% CI [-3.74, 1.77])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-11.84, 8.17], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.20, 95% CI [-1.27, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-2.05, 5.71], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.20, 95% CI [-0.22, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -8.59, 95% CI [-19.37, 2.20], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.92, 95% CI [-2.08, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.38, 95% CI [-14.38, 1.63], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.69, 95% CI [-1.55, 0.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.53, 95% CI [-3.16, 6.22], t(2038) = 0.64, p = 0.523; Std.
## beta = 0.16, 95% CI [-0.34, 0.67])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.89, 95% CI [-0.12, 17.90], t(2038) = 1.93, p = 0.053; Std.
## beta = 0.96, 95% CI [-0.01, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.84, 10.65], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.15])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.64, 4.53], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.11, 95% CI [-0.71, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-5.37, 2.09], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.18, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -31.11, 95% CI [-51.54, -10.68], t(2038) = -2.99, p = 0.003;
## Std. beta = -3.34, 95% CI [-5.54, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-7.72, 10.12], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.13, 95% CI [-0.83, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-9.04, 17.04], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.43, 95% CI [-0.97, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-13.86, 9.46], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.24, 95% CI [-1.49, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.32. The model's intercept,
## corresponding to cohort = CARE-PF, is at 42.90 (95% CI [37.83, 47.97], t(2038)
## = 16.61, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.49, 95% CI [-9.05, -3.93], t(2038) = -4.97, p < .001; Std. beta = -0.50, 95%
## CI [-0.60, -0.40])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -4.85, 95% CI [-14.03, 4.33], t(2038) = -1.04, p = 0.300; Std. beta =
## 0.02, 95% CI [-0.15, 0.19])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-29.19, 24.20], t(2038) = -0.18, p = 0.855; Std. beta = -3.48,
## 95% CI [-6.70, -0.27])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.01, 95% CI [7.35, 46.67], t(2038) = 2.69, p = 0.007; Std. beta = 1.56, 95%
## CI [0.29, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.54, 95% CI [-23.75, 12.67], t(2038) = -0.60, p = 0.551; Std. beta = -0.51,
## 95% CI [-1.91, 0.88])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-28.05, 2.45], t(2038) = -1.65, p = 0.100; Std. beta = -1.18,
## 95% CI [-2.61, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.74, 95% CI [-13.32, 24.81], t(2038) = 0.59, p = 0.555; Std. beta = 0.63,
## 95% CI [-0.71, 1.96])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-2.44, 12.29], t(2038) = 1.31, p = 0.190; Std. beta = 0.13, 95%
## CI [-0.34, 0.60])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-28.07, 9.17], t(2038) = -1.00, p = 0.320; Std. beta = -0.48,
## 95% CI [-1.74, 0.77])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.47, 95% CI [14.30, 24.64], t(2038) = 7.38, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.56, 95% CI [-1.19, 18.31], t(2038) = 1.72, p = 0.085; Std. beta = 0.46, 95%
## CI [-0.17, 1.09])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.83, 95% CI [-7.64, 1.98], t(2038) = -1.15, p = 0.249; Std. beta = 0.02,
## 95% CI [-0.30, 0.35])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.84, 95% CI [-21.42, -0.25], t(2038) = -2.01, p = 0.045; Std. beta = -0.39,
## 95% CI [-1.24, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 0.88, 95% CI [-4.31, 6.08], t(2038) = 0.33, p = 0.739; Std. beta = 0.12, 95%
## CI [-0.23, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.87, 95% CI [-10.50, 2.76], t(2038) = -1.14, p = 0.253; Std. beta = -0.09,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.79, 95% CI [-9.13, 28.72], t(2038) = 1.01, p = 0.310; Std. beta = -0.57,
## 95% CI [-2.13, 1.00])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-22.96, 6.58], t(2038) = -1.09, p = 0.277; Std. beta = -0.13,
## 95% CI [-1.08, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.30, 95% CI [-29.29, 24.69], t(2038) = -0.17, p = 0.867; Std. beta = -0.16,
## 95% CI [-1.98, 1.67])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 4.22, 95% CI [-8.58, 17.01], t(2038) = 0.65, p = 0.518; Std. beta = 0.67, 95%
## CI [-0.18, 1.53])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-27.18, 9.50], t(2038) = -0.95, p = 0.345; Std. beta = -0.44,
## 95% CI [-1.68, 0.81])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.52, 95% CI [-24.92, 3.88], t(2038) = -1.43, p = 0.152; Std. beta = -0.70,
## 95% CI [-1.63, 0.24])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.83, 95% CI [-37.36, 21.69], t(2038) = -0.52, p = 0.603; Std. beta = -1.47,
## 95% CI [-4.65, 1.70])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.93, 95% CI [-49.72, 3.86], t(2038) = -1.68, p = 0.093; Std. beta = -1.77,
## 95% CI [-4.27, 0.72])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.74, 95% CI [-20.34, 2.87], t(2038) = -1.48, p = 0.140; Std. beta = -0.64,
## 95% CI [-1.43, 0.15])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.15, 95% CI [33.34, 86.96], t(2038) = 4.40, p < .001; Std. beta = 4.07, 95%
## CI [2.25, 5.88])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-22.14, 16.28], t(2038) = -0.30, p = 0.765; Std. beta = -1.38,
## 95% CI [-3.78, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.09, 95% CI [-14.91, 12.72], t(2038) = -0.16, p = 0.877; Std. beta = -0.38,
## 95% CI [-1.36, 0.61])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.47, 95% CI [-12.60, 9.66], t(2038) = -0.26, p = 0.795; Std. beta = -0.11,
## 95% CI [-0.91, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-36.91, 13.11], t(2038) = -0.93, p = 0.351; Std. beta =
## -0.33, 95% CI [-1.90, 1.24])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.09, 95% CI [-20.76, -3.42], t(2038) = -2.73, p = 0.006; Std. beta = -0.31,
## 95% CI [-0.94, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.39, 95% CI [-28.71, -2.06], t(2038) = -2.26, p = 0.024; Std. beta = -1.41,
## 95% CI [-2.58, -0.23])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.25, 95% CI [-7.63, 12.14], t(2038) = 0.45, p = 0.655; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -6.35, 95% CI [-17.30, 4.59], t(2038) = -1.14, p = 0.255; Std. beta = -0.58,
## 95% CI [-1.32, 0.15])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.13, 95% CI [-32.67, -1.60], t(2038) = -2.16, p = 0.031; Std. beta = -2.04,
## 95% CI [-4.47, 0.38])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.53, 95% CI [-26.81, 25.74], t(2038) = -0.04, p = 0.968; Std. beta = -0.21,
## 95% CI [-1.82, 1.39])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.36, 95% CI [-11.79, 11.08], t(2038) = -0.06, p = 0.951; Std. beta = 0.15,
## 95% CI [-0.56, 0.87])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 13.45, 95% CI [-6.39, 33.29], t(2038) = 1.33, p = 0.184; Std. beta = 0.08,
## 95% CI [-1.35, 1.50])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.55, 95% CI [-19.23, 10.13], t(2038) = -0.61, p = 0.543; Std. beta = -0.93,
## 95% CI [-1.99, 0.14])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-15.42, 4.52], t(2038) = -1.07, p = 0.284; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.98, 95% CI [-29.47, 1.51], t(2038) = -1.77, p = 0.077; Std. beta = -0.08,
## 95% CI [-1.15, 0.99])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.85, 95% CI [-7.84, 15.53], t(2038) = 0.65, p = 0.519; Std. beta = 0.74, 95%
## CI [-0.08, 1.55])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.52, 95% CI [-11.31, 14.34], t(2038) = 0.23, p = 0.817; Std. beta =
## -3.63e-05, 95% CI [-0.84, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.88, 95% CI [-10.63, 6.87], t(2038) = -0.42, p = 0.673; Std. beta = -0.29,
## 95% CI [-0.85, 0.28])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.91, 95% CI [-18.22, 34.03], t(2038) = 0.59, p = 0.553; Std. beta = -2.48,
## 95% CI [-4.56, -0.40])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-15.17, 21.70], t(2038) = 0.35, p = 0.728; Std. beta = 0.34,
## 95% CI [-0.96, 1.63])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.60, 95% CI [-28.78, 1.57], t(2038) = -1.76, p = 0.079; Std. beta = -0.53,
## 95% CI [-1.84, 0.77])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.27, 95% CI [-17.92, -0.62], t(2038) = -2.10, p = 0.036; Std. beta = -0.84,
## 95% CI [-1.87, 0.19])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 4.02, 95% CI [-0.51, 8.55], t(2038) = 1.74, p = 0.082;
## Std. beta = 0.12, 95% CI [-0.01, 0.25])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.19, 95% CI [-70.52, 2.13], t(2038) = -1.85, p = 0.065;
## Std. beta = -3.68, 95% CI [-7.58, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.79, 95% CI [-14.57, 8.98], t(2038) = -0.47, p = 0.642; Std.
## beta = -0.30, 95% CI [-1.57, 0.97])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.44, 95% CI [-13.69, 10.80], t(2038) = -0.23, p = 0.817;
## Std. beta = -0.16, 95% CI [-1.47, 1.16])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-18.09, 11.50], t(2038) = -0.44, p = 0.662;
## Std. beta = -0.35, 95% CI [-1.94, 1.24])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.45, 95% CI [-7.43, 12.32], t(2038) = 0.49, p = 0.627; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.08, 95% CI [-4.90, 0.75], t(2038) = -1.44, p = 0.150; Std.
## beta = -0.22, 95% CI [-0.53, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-6.63, 9.86], t(2038) = 0.38, p = 0.701; Std.
## beta = 0.17, 95% CI [-0.71, 1.06])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-2.51, 1.97], t(2038) = -0.24, p = 0.813; Std.
## beta = -0.03, 95% CI [-0.27, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-5.47, 3.02], t(2038) = -0.57, p = 0.572; Std.
## beta = -0.13, 95% CI [-0.59, 0.33])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.20, 95% CI [0.04, 4.37], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.24, 95% CI [4.31e-03, 0.47])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.53, 95% CI [-3.86, 10.92], t(2038) = 0.94, p = 0.349; Std.
## beta = 0.38, 95% CI [-0.41, 1.17])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.60, 95% CI [-1.69, 2.89], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.06, 95% CI [-0.18, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.72, 95% CI [-1.45, 4.89], t(2038) = 1.07, p = 0.287; Std.
## beta = 0.19, 95% CI [-0.16, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.68, 95% CI [-28.68, 3.32], t(2038) = -1.55, p = 0.120;
## Std. beta = -1.36, 95% CI [-3.08, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.36, 95% CI [-2.27, 10.99], t(2038) = 1.29, p = 0.197; Std.
## beta = 0.47, 95% CI [-0.24, 1.18])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.02, 95% CI [-1.56, 9.60], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.43, 95% CI [-0.17, 1.03])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.67, 95% CI [-6.14, 9.47], t(2038) = 0.42, p = 0.675; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-7.58, 7.88], t(2038) = 0.04, p = 0.969; Std.
## beta = 0.02, 95% CI [-0.82, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.74, 95% CI [-56.20, 36.72], t(2038) = -0.41, p = 0.681;
## Std. beta = -1.05, 95% CI [-6.04, 3.95])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-30.04, 25.42], t(2038) = -0.16, p = 0.870;
## Std. beta = -0.25, 95% CI [-3.23, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-5.70, 4.64], t(2038) = -0.20, p = 0.841; Std.
## beta = -0.06, 95% CI [-0.61, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-37.72, 13.26], t(2038) = -0.94, p = 0.347;
## Std. beta = -1.31, 95% CI [-4.05, 1.43])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -3.11, 95% CI [-10.80, 4.58], t(2038) = -0.79, p = 0.427; Std.
## beta = -0.33, 95% CI [-1.16, 0.49])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.13, 95% CI [-6.84, 6.57], t(2038) = -0.04, p = 0.969; Std.
## beta = -0.01, 95% CI [-0.73, 0.71])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-4.36, 14.18], t(2038) = 1.04, p = 0.299; Std.
## beta = 0.53, 95% CI [-0.47, 1.52])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.28, 95% CI [-0.25, 10.82], t(2038) = 1.87, p = 0.061; Std.
## beta = 0.57, 95% CI [-0.03, 1.16])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -3.77, 95% CI [-14.67, 7.14], t(2038) = -0.68, p = 0.498; Std.
## beta = -0.41, 95% CI [-1.58, 0.77])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.29, 95% CI [-8.13, 1.54], t(2038) = -1.34, p = 0.181; Std.
## beta = -0.35, 95% CI [-0.87, 0.17])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.60, 95% CI [-7.43, 4.23], t(2038) = -0.54, p = 0.591; Std.
## beta = -0.17, 95% CI [-0.80, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.12, 95% CI [-34.75, 16.50], t(2038) = -0.70, p = 0.485;
## Std. beta = -0.98, 95% CI [-3.74, 1.77])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.84, 95% CI [-11.84, 8.17], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.20, 95% CI [-1.27, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-2.05, 5.71], t(2038) = 0.93, p = 0.355; Std.
## beta = 0.20, 95% CI [-0.22, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -8.59, 95% CI [-19.37, 2.20], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.92, 95% CI [-2.08, 0.24])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.38, 95% CI [-14.38, 1.63], t(2038) = -1.56, p = 0.118; Std.
## beta = -0.69, 95% CI [-1.55, 0.18])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.53, 95% CI [-3.16, 6.22], t(2038) = 0.64, p = 0.523; Std.
## beta = 0.16, 95% CI [-0.34, 0.67])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.89, 95% CI [-0.12, 17.90], t(2038) = 1.93, p = 0.053; Std.
## beta = 0.96, 95% CI [-0.01, 1.92])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.84, 10.65], t(2038) = 1.67, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.15])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.64, 4.53], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.11, 95% CI [-0.71, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-5.37, 2.09], t(2038) = -0.86, p = 0.389; Std.
## beta = -0.18, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -31.11, 95% CI [-51.54, -10.68], t(2038) = -2.99, p = 0.003;
## Std. beta = -3.34, 95% CI [-5.54, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.20, 95% CI [-7.72, 10.12], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.13, 95% CI [-0.83, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.00, 95% CI [-9.04, 17.04], t(2038) = 0.60, p = 0.548; Std.
## beta = 0.43, 95% CI [-0.97, 1.83])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.20, 95% CI [-13.86, 9.46], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.24, 95% CI [-1.49, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*Soil_5yrPreDx + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14677.1
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1223 -0.4896 -0.0085 0.4328 7.0993
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 139.07 11.793
## time_firstPFT 10.90 3.302 -0.28
## Residual 41.79 6.464
## Number of obs: 2117, groups: ID, 455
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 39.39483 5.34711 7.368
## time_firstPFT -4.53844 2.46339 -1.842
## Soil_5yrPreDx -3.13387 4.72212 -0.664
## disadv -5.45024 2.33546 -2.334
## dich_RaceNon-White -2.92320 2.30602 -1.268
## sexF -2.44256 1.42615 -1.713
## age_dx 0.13730 0.07447 1.844
## smokeHxFormer -2.74283 1.41406 -1.940
## smokeHxAlways 9.49292 7.06300 1.344
## smokeHxUnknown -2.87644 3.18754 -0.902
## site02R -6.14390 13.50315 -0.455
## site03R 22.10088 10.02052 2.206
## site04R -5.07006 9.17839 -0.552
## site05R -13.10647 7.72401 -1.697
## site06R -7.39872 13.53102 -0.547
## site07R 3.31021 3.74852 0.883
## site09R -11.43177 9.41292 -1.214
## site101 19.79359 2.65930 7.443
## site102 7.50701 4.97461 1.509
## site103 -2.36633 2.57042 -0.921
## site104 -9.29445 5.39961 -1.721
## site105 1.68378 2.66003 0.633
## site106 -5.81841 3.42412 -1.699
## site107 7.57512 9.56909 0.792
## site108 -2.87107 7.82177 -0.367
## site10R -1.58512 13.80122 -0.115
## site11R 2.53394 6.47710 0.391
## site12R -7.50719 9.25211 -0.811
## site13R -11.98846 7.30063 -1.642
## site14R -9.41306 15.00351 -0.627
## site15R -19.68890 13.55528 -1.452
## site16R -8.28631 5.95167 -1.392
## site17R 64.12880 13.65234 4.697
## site18R -2.11702 9.73682 -0.217
## site19R -3.44098 7.01345 -0.491
## site20R -2.27878 5.64411 -0.404
## site21R -11.91604 12.58579 -0.947
## site22R -14.34545 4.45458 -3.220
## site23R -22.90594 8.28846 -2.764
## site24R 1.72263 4.99376 0.345
## site25R -8.77770 5.59600 -1.569
## site28R -15.66427 7.89048 -1.985
## site29R -3.76153 13.27943 -0.283
## site31R -0.88882 5.83090 -0.152
## site32R 10.73610 10.08054 1.065
## site33R -6.43286 7.43990 -0.865
## site34R -5.24143 5.04011 -1.040
## site35R -14.46518 7.85239 -1.842
## site36R 3.35378 5.92164 0.566
## site37R -0.05295 6.57092 -0.008
## site38R -1.21811 4.42397 -0.275
## site39R 15.21117 13.37528 1.137
## site40R 1.21135 9.31869 0.130
## site41R -14.33302 7.72237 -1.856
## site42R -10.95781 4.42037 -2.479
## time_firstPFT:Soil_5yrPreDx 3.13281 2.40321 1.304
## time_firstPFT:disadv 1.25080 1.10224 1.135
## time_firstPFT:dich_RaceNon-White -0.70216 1.11274 -0.631
## time_firstPFT:sexF 0.56825 0.65914 0.862
## time_firstPFT:age_dx -0.03530 0.03438 -1.027
## time_firstPFT:smokeHxFormer -0.66385 0.66867 -0.993
## time_firstPFT:smokeHxAlways -6.22235 6.03406 -1.031
## time_firstPFT:smokeHxUnknown 2.07724 1.66287 1.249
## time_firstPFT:site02R -32.75364 18.54467 -1.766
## time_firstPFT:site03R -2.11908 6.05466 -0.350
## time_firstPFT:site04R -2.16642 6.28193 -0.345
## time_firstPFT:site05R -3.13461 7.56372 -0.414
## time_firstPFT:site07R -1.65858 1.48158 -1.119
## time_firstPFT:site09R 2.50627 4.23621 0.592
## time_firstPFT:site101 -0.21060 1.16779 -0.180
## time_firstPFT:site102 -0.67513 2.19817 -0.307
## time_firstPFT:site103 2.39753 1.18397 2.025
## time_firstPFT:site104 2.94296 3.84803 0.765
## time_firstPFT:site105 0.55547 1.18162 0.470
## time_firstPFT:site106 2.19958 1.66497 1.321
## time_firstPFT:site107 -12.02459 8.17274 -1.471
## time_firstPFT:site108 5.10388 3.58938 1.422
## time_firstPFT:site11R 4.89176 2.91644 1.677
## time_firstPFT:site12R 2.08497 4.01433 0.519
## time_firstPFT:site13R 0.06527 3.98316 0.016
## time_firstPFT:site14R -8.91192 23.70614 -0.376
## time_firstPFT:site15R -2.40144 14.15904 -0.170
## time_firstPFT:site16R -0.74271 2.69936 -0.275
## time_firstPFT:site18R -11.73987 13.01795 -0.902
## time_firstPFT:site19R -2.02413 4.01000 -0.505
## time_firstPFT:site20R -0.10411 3.47254 -0.030
## time_firstPFT:site21R 5.59891 4.75074 1.179
## time_firstPFT:site22R 6.24976 2.86991 2.178
## time_firstPFT:site23R 20.36062 26.91683 0.756
## time_firstPFT:site24R -2.97042 2.48066 -1.197
## time_firstPFT:site25R -0.75610 3.03860 -0.249
## time_firstPFT:site28R -8.03162 13.14706 -0.611
## time_firstPFT:site29R -0.58817 5.14267 -0.114
## time_firstPFT:site31R 2.47760 2.03060 1.220
## time_firstPFT:site32R -6.43019 5.62550 -1.143
## time_firstPFT:site33R -6.13490 4.16658 -1.472
## time_firstPFT:site34R 1.58690 2.44341 0.649
## time_firstPFT:site35R 9.62280 4.65035 2.069
## time_firstPFT:site36R 5.01502 2.96165 1.693
## time_firstPFT:site37R -0.72648 2.96533 -0.245
## time_firstPFT:site38R -1.62131 1.92079 -0.844
## time_firstPFT:site39R -30.73806 10.48786 -2.931
## time_firstPFT:site40R 1.06093 4.61703 0.230
## time_firstPFT:site41R 4.79051 6.67752 0.717
## time_firstPFT:site42R -2.72085 5.96574 -0.456##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.791
## Unadjusted ICC: 0.527report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## Soil_5yrPreDx + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.86) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to time_firstPFT = 0, is at 39.39 (95% CI [28.91, 49.88], t(2008)
## = 7.37, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## Soil_5yrPreDx (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to Soil_5yrPreDx
## = 0, is at 39.39 (95% CI [28.91, 49.88], t(2008) = 7.37, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to disadv = 0, is at 39.39 (95% CI [28.91,
## 49.88], t(2008) = 7.37, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to dich_Race =
## White, is at 39.39 (95% CI [28.91, 49.88], t(2008) = 7.37, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to sex = M, is at 39.39 (95% CI [28.91,
## 49.88], t(2008) = 7.37, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to age_dx = 0, is at 39.39 (95% CI [28.91,
## 49.88], t(2008) = 7.37, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to smokeHx = Never, is at 39.39 (95% CI
## [28.91, 49.88], t(2008) = 7.37, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.86)
## and the part related to the fixed effects alone (marginal R2) is of 0.33. The
## model's intercept, corresponding to site = Simmons, is at 39.39 (95% CI [28.91,
## 49.88], t(2008) = 7.37, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreDx +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.86) and the part related to the fixed effects alone
## (marginal R2) is of 0.33. The model's intercept, corresponding to cohort =
## CARE-PF, is at 39.39 (95% CI [28.91, 49.88], t(2008) = 7.37, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.54, 95% CI [-9.37, 0.29], t(2008) = -1.84, p = 0.066; Std. beta =
## -0.50, 95% CI [-0.66, -0.33])
## - The effect of Soil 5yrPreDx is statistically non-significant and negative
## (beta = -3.13, 95% CI [-12.39, 6.13], t(2008) = -0.66, p = 0.507; Std. beta =
## 0.02, 95% CI [-0.15, 0.20])
## - The effect of disadv is statistically significant and negative (beta = -5.45,
## 95% CI [-10.03, -0.87], t(2008) = -2.33, p = 0.020; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-7.45, 1.60], t(2008) = -1.27, p = 0.205; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.44, 95% CI [-5.24, 0.35], t(2008) = -1.71, p = 0.087; Std. beta = -0.11, 95%
## CI [-0.30, 0.08])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-8.76e-03, 0.28], t(2008) = 1.84, p = 0.065; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2008) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.49, 95% CI [-4.36, 23.34], t(2008) = 1.34, p = 0.179; Std. beta =
## 0.04, 95% CI [-1.17, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.88, 95% CI [-9.13, 3.37], t(2008) = -0.90, p = 0.367; Std. beta =
## 7.74e-03, 95% CI [-0.44, 0.46])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-32.63, 20.34], t(2008) = -0.45, p = 0.649; Std. beta = -3.60,
## 95% CI [-6.83, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.10, 95% CI [2.45, 41.75], t(2008) = 2.21, p = 0.028; Std. beta = 1.29, 95%
## CI [0.01, 2.56])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.07, 12.93], t(2008) = -0.55, p = 0.581; Std. beta = -0.55,
## 95% CI [-1.95, 0.85])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.11, 95% CI [-28.25, 2.04], t(2008) = -1.70, p = 0.090; Std. beta = -1.19,
## 95% CI [-2.62, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.40, 95% CI [-33.94, 19.14], t(2008) = -0.55, p = 0.585; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.31, 95% CI [-4.04, 10.66], t(2008) = 0.88, p = 0.377; Std. beta = 0.06, 95%
## CI [-0.41, 0.54])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.43, 95% CI [-29.89, 7.03], t(2008) = -1.21, p = 0.225; Std. beta = -0.53,
## 95% CI [-1.78, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.79, 95% CI [14.58, 25.01], t(2008) = 7.44, p < .001; Std. beta = 1.32, 95%
## CI [0.96, 1.67])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.51, 95% CI [-2.25, 17.26], t(2008) = 1.51, p = 0.131; Std. beta = 0.44, 95%
## CI [-0.20, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.37, 95% CI [-7.41, 2.67], t(2008) = -0.92, p = 0.357; Std. beta = 0.07,
## 95% CI [-0.27, 0.42])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.29, 95% CI [-19.88, 1.29], t(2008) = -1.72, p = 0.085; Std. beta = -0.34,
## 95% CI [-1.21, 0.53])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.68, 95% CI [-3.53, 6.90], t(2008) = 0.63, p = 0.527; Std. beta = 0.17, 95%
## CI [-0.18, 0.52])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.82, 95% CI [-12.53, 0.90], t(2008) = -1.70, p = 0.089; Std. beta = -0.18,
## 95% CI [-0.62, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.58, 95% CI [-11.19, 26.34], t(2008) = 0.79, p = 0.429; Std. beta = -0.66,
## 95% CI [-2.22, 0.91])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.87, 95% CI [-18.21, 12.47], t(2008) = -0.37, p = 0.714; Std. beta = 0.30,
## 95% CI [-0.70, 1.30])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.59, 95% CI [-28.65, 25.48], t(2008) = -0.11, p = 0.909; Std. beta = -0.11,
## 95% CI [-1.93, 1.72])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 2.53, 95% CI [-10.17, 15.24], t(2008) = 0.39, p = 0.696; Std. beta = 0.65,
## 95% CI [-0.21, 1.51])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.51, 95% CI [-25.65, 10.64], t(2008) = -0.81, p = 0.417; Std. beta = -0.30,
## 95% CI [-1.55, 0.94])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.99, 95% CI [-26.31, 2.33], t(2008) = -1.64, p = 0.101; Std. beta = -0.80,
## 95% CI [-1.75, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.41, 95% CI [-38.84, 20.01], t(2008) = -0.63, p = 0.530; Std. beta = -1.50,
## 95% CI [-4.69, 1.69])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.69, 95% CI [-46.27, 6.89], t(2008) = -1.45, p = 0.147; Std. beta = -1.56,
## 95% CI [-4.07, 0.94])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.29, 95% CI [-19.96, 3.39], t(2008) = -1.39, p = 0.164; Std. beta = -0.63,
## 95% CI [-1.44, 0.17])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.13, 95% CI [37.35, 90.90], t(2008) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.52, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.12, 95% CI [-21.21, 16.98], t(2008) = -0.22, p = 0.828; Std. beta = -1.28,
## 95% CI [-3.69, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.44, 95% CI [-17.20, 10.31], t(2008) = -0.49, p = 0.624; Std. beta = -0.43,
## 95% CI [-1.43, 0.57])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.28, 95% CI [-13.35, 8.79], t(2008) = -0.40, p = 0.686; Std. beta = -0.16,
## 95% CI [-0.97, 0.64])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-36.60, 12.77], t(2008) = -0.95, p = 0.344; Std. beta =
## -0.26, 95% CI [-1.82, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.35, 95% CI [-23.08, -5.61], t(2008) = -3.22, p = 0.001; Std. beta = -0.36,
## 95% CI [-1.01, 0.28])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.91, 95% CI [-39.16, -6.65], t(2008) = -2.76, p = 0.006; Std. beta = 0.43,
## 95% CI [-4.26, 5.13])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.72, 95% CI [-8.07, 11.52], t(2008) = 0.34, p = 0.730; Std. beta = -0.17,
## 95% CI [-0.83, 0.49])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.78, 95% CI [-19.75, 2.20], t(2008) = -1.57, p = 0.117; Std. beta = -0.67,
## 95% CI [-1.42, 0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.66, 95% CI [-31.14, -0.19], t(2008) = -1.99, p = 0.047; Std. beta = -1.84,
## 95% CI [-4.29, 0.62])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-29.80, 22.28], t(2008) = -0.28, p = 0.777; Std. beta = -0.31,
## 95% CI [-1.91, 1.29])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.89, 95% CI [-12.32, 10.55], t(2008) = -0.15, p = 0.879; Std. beta = 0.18,
## 95% CI [-0.54, 0.91])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.74, 95% CI [-9.03, 30.51], t(2008) = 1.07, p = 0.287; Std. beta = 0.10,
## 95% CI [-1.34, 1.54])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.43, 95% CI [-21.02, 8.16], t(2008) = -0.86, p = 0.387; Std. beta = -1.03,
## 95% CI [-2.11, 0.05])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.24, 95% CI [-15.13, 4.64], t(2008) = -1.04, p = 0.298; Std. beta = -0.20,
## 95% CI [-0.87, 0.47])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.47, 95% CI [-29.86, 0.93], t(2008) = -1.84, p = 0.066; Std. beta = -0.04,
## 95% CI [-1.12, 1.04])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.26, 14.97], t(2008) = 0.57, p = 0.571; Std. beta = 0.71, 95%
## CI [-0.10, 1.53])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.05, 95% CI [-12.94, 12.83], t(2008) = -8.06e-03, p = 0.994; Std. beta =
## -0.07, 95% CI [-0.93, 0.78])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-9.89, 7.46], t(2008) = -0.28, p = 0.783; Std. beta = -0.24,
## 95% CI [-0.81, 0.33])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.21, 95% CI [-11.02, 41.44], t(2008) = 1.14, p = 0.256; Std. beta = -1.96,
## 95% CI [-4.06, 0.14])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-17.06, 19.49], t(2008) = 0.13, p = 0.897; Std. beta = 0.18,
## 95% CI [-1.12, 1.49])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.33, 95% CI [-29.48, 0.81], t(2008) = -1.86, p = 0.064; Std. beta = -0.50,
## 95% CI [-1.82, 0.81])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.96, 95% CI [-19.63, -2.29], t(2008) = -2.48, p = 0.013; Std. beta = -1.00,
## 95% CI [-2.05, 0.04])
## - The effect of time firstPFT × Soil 5yrPreDx is statistically non-significant
## and positive (beta = 3.13, 95% CI [-1.58, 7.85], t(2008) = 1.30, p = 0.193;
## Std. beta = 0.09, 95% CI [-0.05, 0.22])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.25, 95% CI [-0.91, 3.41], t(2008) = 1.13, p = 0.257; Std.
## beta = 0.04, 95% CI [-0.03, 0.11])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.70, 95% CI [-2.88, 1.48], t(2008) =
## -0.63, p = 0.528; Std. beta = -0.08, 95% CI [-0.31, 0.16])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.57, 95% CI [-0.72, 1.86], t(2008) = 0.86, p = 0.389; Std.
## beta = 0.06, 95% CI [-0.08, 0.20])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.10, 0.03], t(2008) = -1.03, p = 0.305; Std.
## beta = -0.03, 95% CI [-0.10, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-1.98, 0.65], t(2008) =
## -0.99, p = 0.321; Std. beta = -0.07, 95% CI [-0.21, 0.07])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.22, 95% CI [-18.06, 5.61], t(2008) =
## -1.03, p = 0.303; Std. beta = -0.67, 95% CI [-1.94, 0.60])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.08, 95% CI [-1.18, 5.34], t(2008) =
## 1.25, p = 0.212; Std. beta = 0.22, 95% CI [-0.13, 0.57])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.75, 95% CI [-69.12, 3.62], t(2008) = -1.77, p = 0.078;
## Std. beta = -3.53, 95% CI [-7.44, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.12, 95% CI [-13.99, 9.76], t(2008) = -0.35, p = 0.726; Std.
## beta = -0.23, 95% CI [-1.51, 1.05])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.17, 95% CI [-14.49, 10.15], t(2008) = -0.34, p = 0.730;
## Std. beta = -0.23, 95% CI [-1.56, 1.09])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.13, 95% CI [-17.97, 11.70], t(2008) = -0.41, p = 0.679;
## Std. beta = -0.34, 95% CI [-1.93, 1.26])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-4.56, 1.25], t(2008) = -1.12, p = 0.263; Std.
## beta = -0.18, 95% CI [-0.49, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.80, 10.81], t(2008) = 0.59, p = 0.554; Std.
## beta = 0.27, 95% CI [-0.62, 1.16])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.21, 95% CI [-2.50, 2.08], t(2008) = -0.18, p = 0.857; Std.
## beta = -0.02, 95% CI [-0.27, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-4.99, 3.64], t(2008) = -0.31, p = 0.759; Std.
## beta = -0.07, 95% CI [-0.54, 0.39])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.40, 95% CI [0.08, 4.72], t(2008) = 2.02, p = 0.043; Std.
## beta = 0.26, 95% CI [8.14e-03, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.94, 95% CI [-4.60, 10.49], t(2008) = 0.76, p = 0.444; Std.
## beta = 0.32, 95% CI [-0.50, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.56, 95% CI [-1.76, 2.87], t(2008) = 0.47, p = 0.638; Std.
## beta = 0.06, 95% CI [-0.19, 0.31])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2008) = 1.32, p = 0.187; Std.
## beta = 0.24, 95% CI [-0.11, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.02, 95% CI [-28.05, 4.00], t(2008) = -1.47, p = 0.141;
## Std. beta = -1.29, 95% CI [-3.02, 0.43])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-1.94, 12.14], t(2008) = 1.42, p = 0.155; Std.
## beta = 0.55, 95% CI [-0.21, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.89, 95% CI [-0.83, 10.61], t(2008) = 1.68, p = 0.094; Std.
## beta = 0.53, 95% CI [-0.09, 1.14])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.08, 95% CI [-5.79, 9.96], t(2008) = 0.52, p = 0.604; Std.
## beta = 0.22, 95% CI [-0.62, 1.07])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-7.75, 7.88], t(2008) = 0.02, p = 0.987; Std.
## beta = 7.03e-03, 95% CI [-0.83, 0.85])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -8.91, 95% CI [-55.40, 37.58], t(2008) = -0.38, p = 0.707;
## Std. beta = -0.96, 95% CI [-5.96, 4.05])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.40, 95% CI [-30.17, 25.37], t(2008) = -0.17, p = 0.865;
## Std. beta = -0.26, 95% CI [-3.25, 2.73])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-6.04, 4.55], t(2008) = -0.28, p = 0.783; Std.
## beta = -0.08, 95% CI [-0.65, 0.49])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.74, 95% CI [-37.27, 13.79], t(2008) = -0.90, p = 0.367;
## Std. beta = -1.26, 95% CI [-4.01, 1.48])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## negative (beta = -2.02, 95% CI [-9.89, 5.84], t(2008) = -0.50, p = 0.614; Std.
## beta = -0.22, 95% CI [-1.06, 0.63])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## negative (beta = -0.10, 95% CI [-6.91, 6.71], t(2008) = -0.03, p = 0.976; Std.
## beta = -0.01, 95% CI [-0.74, 0.72])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.60, 95% CI [-3.72, 14.92], t(2008) = 1.18, p = 0.239; Std.
## beta = 0.60, 95% CI [-0.40, 1.61])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.25, 95% CI [0.62, 11.88], t(2008) = 2.18, p = 0.030; Std.
## beta = 0.67, 95% CI [0.07, 1.28])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 20.36, 95% CI [-32.43, 73.15], t(2008) = 0.76, p = 0.449; Std.
## beta = 2.19, 95% CI [-3.49, 7.87])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.84, 1.89], t(2008) = -1.20, p = 0.231; Std.
## beta = -0.32, 95% CI [-0.84, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-6.72, 5.20], t(2008) = -0.25, p = 0.804; Std.
## beta = -0.08, 95% CI [-0.72, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.03, 95% CI [-33.81, 17.75], t(2008) = -0.61, p = 0.541;
## Std. beta = -0.86, 95% CI [-3.64, 1.91])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-10.67, 9.50], t(2008) = -0.11, p = 0.909; Std.
## beta = -0.06, 95% CI [-1.15, 1.02])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.48, 95% CI [-1.50, 6.46], t(2008) = 1.22, p = 0.223; Std.
## beta = 0.27, 95% CI [-0.16, 0.70])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -6.43, 95% CI [-17.46, 4.60], t(2008) = -1.14, p = 0.253; Std.
## beta = -0.69, 95% CI [-1.88, 0.50])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -6.13, 95% CI [-14.31, 2.04], t(2008) = -1.47, p = 0.141; Std.
## beta = -0.66, 95% CI [-1.54, 0.22])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2008) = 0.65, p = 0.516; Std.
## beta = 0.17, 95% CI [-0.35, 0.69])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.62, 95% CI [0.50, 18.74], t(2008) = 2.07, p = 0.039; Std.
## beta = 1.04, 95% CI [0.05, 2.02])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.79, 10.82], t(2008) = 1.69, p = 0.091; Std.
## beta = 0.54, 95% CI [-0.09, 1.17])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-6.54, 5.09], t(2008) = -0.24, p = 0.806; Std.
## beta = -0.08, 95% CI [-0.70, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-5.39, 2.15], t(2008) = -0.84, p = 0.399; Std.
## beta = -0.17, 95% CI [-0.58, 0.23])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.74, 95% CI [-51.31, -10.17], t(2008) = -2.93, p = 0.003;
## Std. beta = -3.31, 95% CI [-5.52, -1.09])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.06, 95% CI [-7.99, 10.12], t(2008) = 0.23, p = 0.818; Std.
## beta = 0.11, 95% CI [-0.86, 1.09])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.79, 95% CI [-8.31, 17.89], t(2008) = 0.72, p = 0.473; Std.
## beta = 0.52, 95% CI [-0.89, 1.93])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-14.42, 8.98], t(2008) = -0.46, p = 0.648; Std.
## beta = -0.29, 95% CI [-1.55, 0.97])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.Linear mixed models with random intercept and slope will be used to evaluate the impact of PM During Disease on DLCO decline.
DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*PM_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15068.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1356 -0.4972 -0.0044 0.4367 7.1074
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 142.67 11.944
## time_firstPFT 11.15 3.340 -0.31
## Residual 41.83 6.467
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 47.7567 3.6788 12.982
## time_firstPFT -6.3281 1.8118 -3.493
## PM_5yrPreCensor -0.6546 0.3100 -2.112
## site02R -3.3024 13.5806 -0.243
## site03R 23.1878 9.9408 2.333
## site04R -6.5959 9.2759 -0.711
## site05R -14.1574 7.7929 -1.817
## site06R 4.2473 9.6655 0.439
## site07R 3.3921 3.8473 0.882
## site09R -10.8811 9.4866 -1.147
## site101 17.4049 2.8918 6.019
## site102 5.3035 5.2636 1.008
## site103 -5.0145 2.7120 -1.849
## site104 -13.2672 5.5201 -2.403
## site105 -1.0365 2.8617 -0.362
## site106 -5.6402 3.5282 -1.599
## site107 7.6180 9.7017 0.785
## site108 -11.5196 7.7353 -1.489
## site10R -2.5697 13.3884 -0.192
## site11R -1.6952 5.7823 -0.293
## site12R -11.9983 9.4659 -1.268
## site13R -11.9747 7.3772 -1.623
## site14R -8.4720 15.0136 -0.564
## site15R -25.2965 13.6571 -1.852
## site16R -10.2381 5.9680 -1.716
## site17R 57.8917 13.6493 4.241
## site18R -6.2125 9.6676 -0.643
## site19R -9.2658 6.4426 -1.438
## site20R -5.1810 5.6934 -0.910
## site21R -13.5124 12.7042 -1.064
## site22R -12.5812 4.3296 -2.906
## site23R -20.4591 6.1911 -3.305
## site24R -0.2620 5.2054 -0.050
## site25R -7.3098 5.5954 -1.306
## site28R -17.9435 7.9139 -2.267
## site29R -2.0804 13.3651 -0.156
## site31R -2.4980 5.9395 -0.421
## site32R 3.2690 6.7455 0.485
## site33R -10.3292 6.6747 -1.548
## site34R -7.1965 5.1596 -1.395
## site35R -16.7617 8.0206 -2.090
## site36R 1.6918 6.0359 0.280
## site37R 0.2292 6.5546 0.035
## site38R -3.7637 4.5788 -0.822
## site39R 3.2322 13.3737 0.242
## site40R 0.8563 9.2884 0.092
## site41R -15.3755 7.7817 -1.976
## site42R -10.0359 4.4032 -2.279
## time_firstPFT:PM_5yrPreCensor 0.1823 0.1569 1.162
## time_firstPFT:site02R -34.4399 18.5486 -1.857
## time_firstPFT:site03R -0.6851 5.9633 -0.115
## time_firstPFT:site04R -1.5397 6.2726 -0.245
## time_firstPFT:site05R -3.2445 7.5676 -0.429
## time_firstPFT:site06R 3.2342 5.0482 0.641
## time_firstPFT:site07R -2.1781 1.5058 -1.446
## time_firstPFT:site09R 1.4445 4.2484 0.340
## time_firstPFT:site101 -0.3353 1.2486 -0.269
## time_firstPFT:site102 -0.6970 2.3388 -0.298
## time_firstPFT:site103 2.0433 1.2441 1.642
## time_firstPFT:site104 3.2376 3.8143 0.849
## time_firstPFT:site105 0.4334 1.2606 0.344
## time_firstPFT:site106 1.8137 1.6994 1.067
## time_firstPFT:site107 -12.7407 8.1957 -1.555
## time_firstPFT:site108 4.6988 3.5108 1.338
## time_firstPFT:site11R 5.2369 2.7853 1.880
## time_firstPFT:site12R 1.9762 4.0644 0.486
## time_firstPFT:site13R -0.1097 3.9776 -0.028
## time_firstPFT:site14R -10.5950 23.7038 -0.447
## time_firstPFT:site15R -1.6394 14.1697 -0.116
## time_firstPFT:site16R -0.7124 2.6869 -0.265
## time_firstPFT:site18R -10.4712 12.9896 -0.806
## time_firstPFT:site19R 3.3138 4.9171 0.674
## time_firstPFT:site20R 1.4326 3.4536 0.415
## time_firstPFT:site21R 5.5385 4.7606 1.163
## time_firstPFT:site22R 4.6916 2.8133 1.668
## time_firstPFT:site23R -0.6123 5.3983 -0.113
## time_firstPFT:site24R -2.8761 2.5695 -1.119
## time_firstPFT:site25R -1.8326 3.0031 -0.610
## time_firstPFT:site28R -9.3302 13.0810 -0.713
## time_firstPFT:site29R -2.3635 5.1284 -0.461
## time_firstPFT:site31R 1.8780 2.0789 0.903
## time_firstPFT:site32R -0.8711 3.5713 -0.244
## time_firstPFT:site33R -2.8717 3.8023 -0.755
## time_firstPFT:site34R 1.3429 2.4490 0.548
## time_firstPFT:site35R 9.2657 4.6961 1.973
## time_firstPFT:site36R 5.4806 3.0001 1.827
## time_firstPFT:site37R -1.2058 2.8784 -0.419
## time_firstPFT:site38R -1.5904 1.9738 -0.806
## time_firstPFT:site39R -29.4471 10.4693 -2.813
## time_firstPFT:site40R 2.3714 4.6241 0.513
## time_firstPFT:site41R 4.0692 6.6804 0.609
## time_firstPFT:site42R -2.6321 5.9398 -0.443##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.801
## Unadjusted ICC: 0.527report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## PM_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.34. The model's
## intercept, corresponding to time_firstPFT = 0, is at 47.76 (95% CI [40.54,
## 54.97], t(2068) = 12.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.33, 95% CI [-9.88, -2.78], t(2068) = -3.49, p < .001; Std. beta = -0.59, 95%
## CI [-0.73, -0.44])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.65, 95% CI [-1.26, -0.05], t(2068) = -2.11, p = 0.035; Std. beta = -0.07,
## 95% CI [-0.20, 0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-29.94, 23.33], t(2068) = -0.24, p = 0.808; Std. beta = -3.76,
## 95% CI [-7.17, -0.36])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.19, 95% CI [3.69, 42.68], t(2068) = 2.33, p = 0.020; Std. beta = 1.51, 95%
## CI [0.23, 2.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.60, 95% CI [-24.79, 11.60], t(2068) = -0.71, p = 0.477; Std. beta = -0.61,
## 95% CI [-2.05, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.16, 95% CI [-29.44, 1.13], t(2068) = -1.82, p = 0.069; Std. beta = -1.30,
## 95% CI [-2.79, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.71, 23.20], t(2068) = 0.44, p = 0.660; Std. beta = 0.62,
## 95% CI [-0.74, 1.98])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-4.15, 10.94], t(2068) = 0.88, p = 0.378; Std. beta = 6.82e-03,
## 95% CI [-0.48, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.88, 95% CI [-29.49, 7.72], t(2068) = -1.15, p = 0.252; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.40, 95% CI [11.73, 23.08], t(2068) = 6.02, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.54])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-5.02, 15.63], t(2068) = 1.01, p = 0.314; Std. beta = 0.29, 95%
## CI [-0.40, 0.98])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-10.33, 0.30], t(2068) = -1.85, p = 0.065; Std. beta = -0.13,
## 95% CI [-0.50, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.27, 95% CI [-24.09, -2.44], t(2068) = -2.40, p = 0.016; Std. beta = -0.57,
## 95% CI [-1.47, 0.33])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.65, 4.58], t(2068) = -0.36, p = 0.717; Std. beta = -0.03,
## 95% CI [-0.41, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-12.56, 1.28], t(2068) = -1.60, p = 0.110; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.62, 95% CI [-11.41, 26.64], t(2068) = 0.79, p = 0.432; Std. beta = -0.79,
## 95% CI [-2.43, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-26.69, 3.65], t(2068) = -1.49, p = 0.137; Std. beta = -0.30,
## 95% CI [-1.29, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-28.83, 23.69], t(2068) = -0.19, p = 0.848; Std. beta = -0.17,
## 95% CI [-1.96, 1.61])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-13.03, 9.64], t(2068) = -0.29, p = 0.769; Std. beta = 0.42,
## 95% CI [-0.37, 1.22])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-30.56, 6.57], t(2068) = -1.27, p = 0.205; Std. beta = -0.61,
## 95% CI [-1.90, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.97, 95% CI [-26.44, 2.49], t(2068) = -1.62, p = 0.105; Std. beta = -0.83,
## 95% CI [-1.79, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.47, 95% CI [-37.92, 20.97], t(2068) = -0.56, p = 0.573; Std. beta = -1.67,
## 95% CI [-5.08, 1.75])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -25.30, 95% CI [-52.08, 1.49], t(2068) = -1.85, p = 0.064; Std. beta = -1.89,
## 95% CI [-4.52, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.94, 1.47], t(2068) = -1.72, p = 0.086; Std. beta = -0.77,
## 95% CI [-1.58, 0.05])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.89, 95% CI [31.12, 84.66], t(2068) = 4.24, p < .001; Std. beta = 3.94, 95%
## CI [2.12, 5.76])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-25.17, 12.75], t(2068) = -0.64, p = 0.521; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-21.90, 3.37], t(2068) = -1.44, p = 0.151; Std. beta = -0.29,
## 95% CI [-1.36, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.18, 95% CI [-16.35, 5.98], t(2068) = -0.91, p = 0.363; Std. beta = -0.21,
## 95% CI [-1.03, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-38.43, 11.40], t(2068) = -1.06, p = 0.288; Std. beta =
## -0.35, 95% CI [-1.93, 1.23])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.58, 95% CI [-21.07, -4.09], t(2068) = -2.91, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.02, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.46, 95% CI [-32.60, -8.32], t(2068) = -3.30, p < .001; Std. beta = -1.45,
## 95% CI [-2.62, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.47, 9.95], t(2068) = -0.05, p = 0.960; Std. beta = -0.31,
## 95% CI [-1.01, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-18.28, 3.66], t(2068) = -1.31, p = 0.192; Std. beta = -0.69,
## 95% CI [-1.44, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.94, 95% CI [-33.46, -2.42], t(2068) = -2.27, p = 0.023; Std. beta = -2.18,
## 95% CI [-4.75, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.08, 95% CI [-28.29, 24.13], t(2068) = -0.16, p = 0.876; Std. beta = -0.38,
## 95% CI [-2.00, 1.23])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-14.15, 9.15], t(2068) = -0.42, p = 0.674; Std. beta = 0.02,
## 95% CI [-0.72, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-9.96, 16.50], t(2068) = 0.48, p = 0.628; Std. beta = 0.13, 95%
## CI [-0.80, 1.06])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2068) = -1.55, p = 0.122; Std. beta = -1.00,
## 95% CI [-1.99, -1.43e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.20, 95% CI [-17.31, 2.92], t(2068) = -1.39, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [35R] is statistically significant and negative (beta =
## -16.76, 95% CI [-32.49, -1.03], t(2068) = -2.09, p = 0.037; Std. beta = -0.19,
## 95% CI [-1.31, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 1.69, 95% CI [-10.15, 13.53], t(2068) = 0.28, p = 0.779; Std. beta = 0.68,
## 95% CI [-0.16, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-12.63, 13.08], t(2068) = 0.03, p = 0.972; Std. beta = -0.11,
## 95% CI [-0.96, 0.74])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-12.74, 5.22], t(2068) = -0.82, p = 0.411; Std. beta = -0.42,
## 95% CI [-1.01, 0.18])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 3.23, 95% CI [-23.00, 29.46], t(2068) = 0.24, p = 0.809; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.86, 95% CI [-17.36, 19.07], t(2068) = 0.09, p = 0.927; Std. beta = 0.30,
## 95% CI [-1.02, 1.62])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.38, 95% CI [-30.64, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.63,
## 95% CI [-2.00, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.04, 95% CI [-18.67, -1.40], t(2068) = -2.28, p = 0.023; Std. beta = -0.95,
## 95% CI [-2.04, 0.14])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.18, 95% CI [-0.13, 0.49], t(2068) =
## 1.16, p = 0.245; Std. beta = 0.06, 95% CI [-0.04, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.44, 95% CI [-70.82, 1.94], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.27, 95% CI [-8.77, 0.24])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.38, 11.01], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.08, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-13.84, 10.76], t(2068) = -0.25, p = 0.806;
## Std. beta = -0.19, 95% CI [-1.71, 1.33])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.24, 95% CI [-18.09, 11.60], t(2068) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.24, 1.44])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-6.67, 13.13], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.13, 0.78], t(2068) = -1.45, p = 0.148; Std.
## beta = -0.27, 95% CI [-0.64, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.89, 9.78], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.18, 95% CI [-0.85, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-2.78, 2.11], t(2068) = -0.27, p = 0.788; Std.
## beta = -0.04, 95% CI [-0.34, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-5.28, 3.89], t(2068) = -0.30, p = 0.766; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-0.40, 4.48], t(2068) = 1.64, p = 0.101; Std.
## beta = 0.25, 95% CI [-0.05, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.24, 10.72], t(2068) = 0.85, p = 0.396; Std.
## beta = 0.40, 95% CI [-0.53, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.43, 95% CI [-2.04, 2.91], t(2068) = 0.34, p = 0.731; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.52, 5.15], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.22, 95% CI [-0.19, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.74, 95% CI [-28.81, 3.33], t(2068) = -1.55, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.19, 11.58], t(2068) = 1.34, p = 0.181; Std.
## beta = 0.58, 95% CI [-0.27, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.23, 10.70], t(2068) = 1.88, p = 0.060; Std.
## beta = 0.65, 95% CI [-0.03, 1.33])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-5.99, 9.95], t(2068) = 0.49, p = 0.627; Std.
## beta = 0.24, 95% CI [-0.74, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-7.91, 7.69], t(2068) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.98, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.60, 95% CI [-57.08, 35.89], t(2068) = -0.45, p = 0.655;
## Std. beta = -1.31, 95% CI [-7.07, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.43, 26.15], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.65, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-5.98, 4.56], t(2068) = -0.27, p = 0.791; Std.
## beta = -0.09, 95% CI [-0.74, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.95, 15.00], t(2068) = -0.81, p = 0.420;
## Std. beta = -1.30, 95% CI [-4.45, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-6.33, 12.96], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.41, 95% CI [-0.78, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-5.34, 8.21], t(2068) = 0.41, p = 0.678; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.54, 95% CI [-3.80, 14.87], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.69, 95% CI [-0.47, 1.84])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-0.83, 10.21], t(2068) = 1.67, p = 0.096; Std.
## beta = 0.58, 95% CI [-0.10, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-11.20, 9.97], t(2068) = -0.11, p = 0.910; Std.
## beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-7.92, 2.16], t(2068) = -1.12, p = 0.263; Std.
## beta = -0.36, 95% CI [-0.98, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.72, 4.06], t(2068) = -0.61, p = 0.542; Std.
## beta = -0.23, 95% CI [-0.96, 0.50])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.33, 95% CI [-34.98, 16.32], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-12.42, 7.69], t(2068) = -0.46, p = 0.645; Std.
## beta = -0.29, 95% CI [-1.54, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.20, 5.96], t(2068) = 0.90, p = 0.366; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-7.87, 6.13], t(2068) = -0.24, p = 0.807; Std.
## beta = -0.11, 95% CI [-0.98, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-10.33, 4.59], t(2068) = -0.76, p = 0.450; Std.
## beta = -0.36, 95% CI [-1.28, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-3.46, 6.15], t(2068) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.06, 18.48], t(2068) = 1.97, p = 0.049; Std.
## beta = 1.15, 95% CI [6.95e-03, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.40, 11.36], t(2068) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-6.85, 4.44], t(2068) = -0.42, p = 0.675; Std.
## beta = -0.15, 95% CI [-0.85, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-5.46, 2.28], t(2068) = -0.81, p = 0.420; Std.
## beta = -0.20, 95% CI [-0.68, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.45, 95% CI [-49.98, -8.92], t(2068) = -2.81, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.10])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-6.70, 11.44], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.29, 95% CI [-0.83, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.07, 95% CI [-9.03, 17.17], t(2068) = 0.61, p = 0.543; Std.
## beta = 0.50, 95% CI [-1.12, 2.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-14.28, 9.02], t(2068) = -0.44, p = 0.658; Std.
## beta = -0.33, 95% CI [-1.77, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## PM_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to PM_5yrPreCensor = 0, is at 47.76 (95% CI [40.54, 54.97],
## t(2068) = 12.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.33, 95% CI [-9.88, -2.78], t(2068) = -3.49, p < .001; Std. beta = -0.59, 95%
## CI [-0.73, -0.44])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.65, 95% CI [-1.26, -0.05], t(2068) = -2.11, p = 0.035; Std. beta = -0.07,
## 95% CI [-0.20, 0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-29.94, 23.33], t(2068) = -0.24, p = 0.808; Std. beta = -3.76,
## 95% CI [-7.17, -0.36])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.19, 95% CI [3.69, 42.68], t(2068) = 2.33, p = 0.020; Std. beta = 1.51, 95%
## CI [0.23, 2.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.60, 95% CI [-24.79, 11.60], t(2068) = -0.71, p = 0.477; Std. beta = -0.61,
## 95% CI [-2.05, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.16, 95% CI [-29.44, 1.13], t(2068) = -1.82, p = 0.069; Std. beta = -1.30,
## 95% CI [-2.79, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.71, 23.20], t(2068) = 0.44, p = 0.660; Std. beta = 0.62,
## 95% CI [-0.74, 1.98])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-4.15, 10.94], t(2068) = 0.88, p = 0.378; Std. beta = 6.82e-03,
## 95% CI [-0.48, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.88, 95% CI [-29.49, 7.72], t(2068) = -1.15, p = 0.252; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.40, 95% CI [11.73, 23.08], t(2068) = 6.02, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.54])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-5.02, 15.63], t(2068) = 1.01, p = 0.314; Std. beta = 0.29, 95%
## CI [-0.40, 0.98])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-10.33, 0.30], t(2068) = -1.85, p = 0.065; Std. beta = -0.13,
## 95% CI [-0.50, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.27, 95% CI [-24.09, -2.44], t(2068) = -2.40, p = 0.016; Std. beta = -0.57,
## 95% CI [-1.47, 0.33])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.65, 4.58], t(2068) = -0.36, p = 0.717; Std. beta = -0.03,
## 95% CI [-0.41, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-12.56, 1.28], t(2068) = -1.60, p = 0.110; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.62, 95% CI [-11.41, 26.64], t(2068) = 0.79, p = 0.432; Std. beta = -0.79,
## 95% CI [-2.43, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-26.69, 3.65], t(2068) = -1.49, p = 0.137; Std. beta = -0.30,
## 95% CI [-1.29, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-28.83, 23.69], t(2068) = -0.19, p = 0.848; Std. beta = -0.17,
## 95% CI [-1.96, 1.61])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-13.03, 9.64], t(2068) = -0.29, p = 0.769; Std. beta = 0.42,
## 95% CI [-0.37, 1.22])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-30.56, 6.57], t(2068) = -1.27, p = 0.205; Std. beta = -0.61,
## 95% CI [-1.90, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.97, 95% CI [-26.44, 2.49], t(2068) = -1.62, p = 0.105; Std. beta = -0.83,
## 95% CI [-1.79, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.47, 95% CI [-37.92, 20.97], t(2068) = -0.56, p = 0.573; Std. beta = -1.67,
## 95% CI [-5.08, 1.75])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -25.30, 95% CI [-52.08, 1.49], t(2068) = -1.85, p = 0.064; Std. beta = -1.89,
## 95% CI [-4.52, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.94, 1.47], t(2068) = -1.72, p = 0.086; Std. beta = -0.77,
## 95% CI [-1.58, 0.05])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.89, 95% CI [31.12, 84.66], t(2068) = 4.24, p < .001; Std. beta = 3.94, 95%
## CI [2.12, 5.76])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-25.17, 12.75], t(2068) = -0.64, p = 0.521; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-21.90, 3.37], t(2068) = -1.44, p = 0.151; Std. beta = -0.29,
## 95% CI [-1.36, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.18, 95% CI [-16.35, 5.98], t(2068) = -0.91, p = 0.363; Std. beta = -0.21,
## 95% CI [-1.03, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-38.43, 11.40], t(2068) = -1.06, p = 0.288; Std. beta =
## -0.35, 95% CI [-1.93, 1.23])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.58, 95% CI [-21.07, -4.09], t(2068) = -2.91, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.02, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.46, 95% CI [-32.60, -8.32], t(2068) = -3.30, p < .001; Std. beta = -1.45,
## 95% CI [-2.62, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.47, 9.95], t(2068) = -0.05, p = 0.960; Std. beta = -0.31,
## 95% CI [-1.01, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-18.28, 3.66], t(2068) = -1.31, p = 0.192; Std. beta = -0.69,
## 95% CI [-1.44, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.94, 95% CI [-33.46, -2.42], t(2068) = -2.27, p = 0.023; Std. beta = -2.18,
## 95% CI [-4.75, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.08, 95% CI [-28.29, 24.13], t(2068) = -0.16, p = 0.876; Std. beta = -0.38,
## 95% CI [-2.00, 1.23])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-14.15, 9.15], t(2068) = -0.42, p = 0.674; Std. beta = 0.02,
## 95% CI [-0.72, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-9.96, 16.50], t(2068) = 0.48, p = 0.628; Std. beta = 0.13, 95%
## CI [-0.80, 1.06])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2068) = -1.55, p = 0.122; Std. beta = -1.00,
## 95% CI [-1.99, -1.43e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.20, 95% CI [-17.31, 2.92], t(2068) = -1.39, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [35R] is statistically significant and negative (beta =
## -16.76, 95% CI [-32.49, -1.03], t(2068) = -2.09, p = 0.037; Std. beta = -0.19,
## 95% CI [-1.31, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 1.69, 95% CI [-10.15, 13.53], t(2068) = 0.28, p = 0.779; Std. beta = 0.68,
## 95% CI [-0.16, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-12.63, 13.08], t(2068) = 0.03, p = 0.972; Std. beta = -0.11,
## 95% CI [-0.96, 0.74])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-12.74, 5.22], t(2068) = -0.82, p = 0.411; Std. beta = -0.42,
## 95% CI [-1.01, 0.18])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 3.23, 95% CI [-23.00, 29.46], t(2068) = 0.24, p = 0.809; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.86, 95% CI [-17.36, 19.07], t(2068) = 0.09, p = 0.927; Std. beta = 0.30,
## 95% CI [-1.02, 1.62])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.38, 95% CI [-30.64, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.63,
## 95% CI [-2.00, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.04, 95% CI [-18.67, -1.40], t(2068) = -2.28, p = 0.023; Std. beta = -0.95,
## 95% CI [-2.04, 0.14])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.18, 95% CI [-0.13, 0.49], t(2068) =
## 1.16, p = 0.245; Std. beta = 0.06, 95% CI [-0.04, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.44, 95% CI [-70.82, 1.94], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.27, 95% CI [-8.77, 0.24])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.38, 11.01], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.08, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-13.84, 10.76], t(2068) = -0.25, p = 0.806;
## Std. beta = -0.19, 95% CI [-1.71, 1.33])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.24, 95% CI [-18.09, 11.60], t(2068) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.24, 1.44])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-6.67, 13.13], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.13, 0.78], t(2068) = -1.45, p = 0.148; Std.
## beta = -0.27, 95% CI [-0.64, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.89, 9.78], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.18, 95% CI [-0.85, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-2.78, 2.11], t(2068) = -0.27, p = 0.788; Std.
## beta = -0.04, 95% CI [-0.34, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-5.28, 3.89], t(2068) = -0.30, p = 0.766; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-0.40, 4.48], t(2068) = 1.64, p = 0.101; Std.
## beta = 0.25, 95% CI [-0.05, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.24, 10.72], t(2068) = 0.85, p = 0.396; Std.
## beta = 0.40, 95% CI [-0.53, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.43, 95% CI [-2.04, 2.91], t(2068) = 0.34, p = 0.731; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.52, 5.15], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.22, 95% CI [-0.19, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.74, 95% CI [-28.81, 3.33], t(2068) = -1.55, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.19, 11.58], t(2068) = 1.34, p = 0.181; Std.
## beta = 0.58, 95% CI [-0.27, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.23, 10.70], t(2068) = 1.88, p = 0.060; Std.
## beta = 0.65, 95% CI [-0.03, 1.33])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-5.99, 9.95], t(2068) = 0.49, p = 0.627; Std.
## beta = 0.24, 95% CI [-0.74, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-7.91, 7.69], t(2068) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.98, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.60, 95% CI [-57.08, 35.89], t(2068) = -0.45, p = 0.655;
## Std. beta = -1.31, 95% CI [-7.07, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.43, 26.15], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.65, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-5.98, 4.56], t(2068) = -0.27, p = 0.791; Std.
## beta = -0.09, 95% CI [-0.74, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.95, 15.00], t(2068) = -0.81, p = 0.420;
## Std. beta = -1.30, 95% CI [-4.45, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-6.33, 12.96], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.41, 95% CI [-0.78, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-5.34, 8.21], t(2068) = 0.41, p = 0.678; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.54, 95% CI [-3.80, 14.87], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.69, 95% CI [-0.47, 1.84])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-0.83, 10.21], t(2068) = 1.67, p = 0.096; Std.
## beta = 0.58, 95% CI [-0.10, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-11.20, 9.97], t(2068) = -0.11, p = 0.910; Std.
## beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-7.92, 2.16], t(2068) = -1.12, p = 0.263; Std.
## beta = -0.36, 95% CI [-0.98, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.72, 4.06], t(2068) = -0.61, p = 0.542; Std.
## beta = -0.23, 95% CI [-0.96, 0.50])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.33, 95% CI [-34.98, 16.32], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-12.42, 7.69], t(2068) = -0.46, p = 0.645; Std.
## beta = -0.29, 95% CI [-1.54, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.20, 5.96], t(2068) = 0.90, p = 0.366; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-7.87, 6.13], t(2068) = -0.24, p = 0.807; Std.
## beta = -0.11, 95% CI [-0.98, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-10.33, 4.59], t(2068) = -0.76, p = 0.450; Std.
## beta = -0.36, 95% CI [-1.28, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-3.46, 6.15], t(2068) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.06, 18.48], t(2068) = 1.97, p = 0.049; Std.
## beta = 1.15, 95% CI [6.95e-03, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.40, 11.36], t(2068) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-6.85, 4.44], t(2068) = -0.42, p = 0.675; Std.
## beta = -0.15, 95% CI [-0.85, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-5.46, 2.28], t(2068) = -0.81, p = 0.420; Std.
## beta = -0.20, 95% CI [-0.68, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.45, 95% CI [-49.98, -8.92], t(2068) = -2.81, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.10])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-6.70, 11.44], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.29, 95% CI [-0.83, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.07, 95% CI [-9.03, 17.17], t(2068) = 0.61, p = 0.543; Std.
## beta = 0.50, 95% CI [-1.12, 2.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-14.28, 9.02], t(2068) = -0.44, p = 0.658; Std.
## beta = -0.33, 95% CI [-1.77, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.34. The model's intercept, corresponding to site =
## Simmons, is at 47.76 (95% CI [40.54, 54.97], t(2068) = 12.98, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.33, 95% CI [-9.88, -2.78], t(2068) = -3.49, p < .001; Std. beta = -0.59, 95%
## CI [-0.73, -0.44])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.65, 95% CI [-1.26, -0.05], t(2068) = -2.11, p = 0.035; Std. beta = -0.07,
## 95% CI [-0.20, 0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-29.94, 23.33], t(2068) = -0.24, p = 0.808; Std. beta = -3.76,
## 95% CI [-7.17, -0.36])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.19, 95% CI [3.69, 42.68], t(2068) = 2.33, p = 0.020; Std. beta = 1.51, 95%
## CI [0.23, 2.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.60, 95% CI [-24.79, 11.60], t(2068) = -0.71, p = 0.477; Std. beta = -0.61,
## 95% CI [-2.05, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.16, 95% CI [-29.44, 1.13], t(2068) = -1.82, p = 0.069; Std. beta = -1.30,
## 95% CI [-2.79, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.71, 23.20], t(2068) = 0.44, p = 0.660; Std. beta = 0.62,
## 95% CI [-0.74, 1.98])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-4.15, 10.94], t(2068) = 0.88, p = 0.378; Std. beta = 6.82e-03,
## 95% CI [-0.48, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.88, 95% CI [-29.49, 7.72], t(2068) = -1.15, p = 0.252; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.40, 95% CI [11.73, 23.08], t(2068) = 6.02, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.54])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-5.02, 15.63], t(2068) = 1.01, p = 0.314; Std. beta = 0.29, 95%
## CI [-0.40, 0.98])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-10.33, 0.30], t(2068) = -1.85, p = 0.065; Std. beta = -0.13,
## 95% CI [-0.50, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.27, 95% CI [-24.09, -2.44], t(2068) = -2.40, p = 0.016; Std. beta = -0.57,
## 95% CI [-1.47, 0.33])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.65, 4.58], t(2068) = -0.36, p = 0.717; Std. beta = -0.03,
## 95% CI [-0.41, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-12.56, 1.28], t(2068) = -1.60, p = 0.110; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.62, 95% CI [-11.41, 26.64], t(2068) = 0.79, p = 0.432; Std. beta = -0.79,
## 95% CI [-2.43, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-26.69, 3.65], t(2068) = -1.49, p = 0.137; Std. beta = -0.30,
## 95% CI [-1.29, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-28.83, 23.69], t(2068) = -0.19, p = 0.848; Std. beta = -0.17,
## 95% CI [-1.96, 1.61])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-13.03, 9.64], t(2068) = -0.29, p = 0.769; Std. beta = 0.42,
## 95% CI [-0.37, 1.22])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-30.56, 6.57], t(2068) = -1.27, p = 0.205; Std. beta = -0.61,
## 95% CI [-1.90, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.97, 95% CI [-26.44, 2.49], t(2068) = -1.62, p = 0.105; Std. beta = -0.83,
## 95% CI [-1.79, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.47, 95% CI [-37.92, 20.97], t(2068) = -0.56, p = 0.573; Std. beta = -1.67,
## 95% CI [-5.08, 1.75])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -25.30, 95% CI [-52.08, 1.49], t(2068) = -1.85, p = 0.064; Std. beta = -1.89,
## 95% CI [-4.52, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.94, 1.47], t(2068) = -1.72, p = 0.086; Std. beta = -0.77,
## 95% CI [-1.58, 0.05])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.89, 95% CI [31.12, 84.66], t(2068) = 4.24, p < .001; Std. beta = 3.94, 95%
## CI [2.12, 5.76])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-25.17, 12.75], t(2068) = -0.64, p = 0.521; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-21.90, 3.37], t(2068) = -1.44, p = 0.151; Std. beta = -0.29,
## 95% CI [-1.36, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.18, 95% CI [-16.35, 5.98], t(2068) = -0.91, p = 0.363; Std. beta = -0.21,
## 95% CI [-1.03, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-38.43, 11.40], t(2068) = -1.06, p = 0.288; Std. beta =
## -0.35, 95% CI [-1.93, 1.23])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.58, 95% CI [-21.07, -4.09], t(2068) = -2.91, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.02, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.46, 95% CI [-32.60, -8.32], t(2068) = -3.30, p < .001; Std. beta = -1.45,
## 95% CI [-2.62, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.47, 9.95], t(2068) = -0.05, p = 0.960; Std. beta = -0.31,
## 95% CI [-1.01, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-18.28, 3.66], t(2068) = -1.31, p = 0.192; Std. beta = -0.69,
## 95% CI [-1.44, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.94, 95% CI [-33.46, -2.42], t(2068) = -2.27, p = 0.023; Std. beta = -2.18,
## 95% CI [-4.75, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.08, 95% CI [-28.29, 24.13], t(2068) = -0.16, p = 0.876; Std. beta = -0.38,
## 95% CI [-2.00, 1.23])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-14.15, 9.15], t(2068) = -0.42, p = 0.674; Std. beta = 0.02,
## 95% CI [-0.72, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-9.96, 16.50], t(2068) = 0.48, p = 0.628; Std. beta = 0.13, 95%
## CI [-0.80, 1.06])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2068) = -1.55, p = 0.122; Std. beta = -1.00,
## 95% CI [-1.99, -1.43e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.20, 95% CI [-17.31, 2.92], t(2068) = -1.39, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [35R] is statistically significant and negative (beta =
## -16.76, 95% CI [-32.49, -1.03], t(2068) = -2.09, p = 0.037; Std. beta = -0.19,
## 95% CI [-1.31, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 1.69, 95% CI [-10.15, 13.53], t(2068) = 0.28, p = 0.779; Std. beta = 0.68,
## 95% CI [-0.16, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-12.63, 13.08], t(2068) = 0.03, p = 0.972; Std. beta = -0.11,
## 95% CI [-0.96, 0.74])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-12.74, 5.22], t(2068) = -0.82, p = 0.411; Std. beta = -0.42,
## 95% CI [-1.01, 0.18])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 3.23, 95% CI [-23.00, 29.46], t(2068) = 0.24, p = 0.809; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.86, 95% CI [-17.36, 19.07], t(2068) = 0.09, p = 0.927; Std. beta = 0.30,
## 95% CI [-1.02, 1.62])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.38, 95% CI [-30.64, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.63,
## 95% CI [-2.00, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.04, 95% CI [-18.67, -1.40], t(2068) = -2.28, p = 0.023; Std. beta = -0.95,
## 95% CI [-2.04, 0.14])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.18, 95% CI [-0.13, 0.49], t(2068) =
## 1.16, p = 0.245; Std. beta = 0.06, 95% CI [-0.04, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.44, 95% CI [-70.82, 1.94], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.27, 95% CI [-8.77, 0.24])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.38, 11.01], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.08, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-13.84, 10.76], t(2068) = -0.25, p = 0.806;
## Std. beta = -0.19, 95% CI [-1.71, 1.33])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.24, 95% CI [-18.09, 11.60], t(2068) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.24, 1.44])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-6.67, 13.13], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.13, 0.78], t(2068) = -1.45, p = 0.148; Std.
## beta = -0.27, 95% CI [-0.64, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.89, 9.78], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.18, 95% CI [-0.85, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-2.78, 2.11], t(2068) = -0.27, p = 0.788; Std.
## beta = -0.04, 95% CI [-0.34, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-5.28, 3.89], t(2068) = -0.30, p = 0.766; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-0.40, 4.48], t(2068) = 1.64, p = 0.101; Std.
## beta = 0.25, 95% CI [-0.05, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.24, 10.72], t(2068) = 0.85, p = 0.396; Std.
## beta = 0.40, 95% CI [-0.53, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.43, 95% CI [-2.04, 2.91], t(2068) = 0.34, p = 0.731; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.52, 5.15], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.22, 95% CI [-0.19, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.74, 95% CI [-28.81, 3.33], t(2068) = -1.55, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.19, 11.58], t(2068) = 1.34, p = 0.181; Std.
## beta = 0.58, 95% CI [-0.27, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.23, 10.70], t(2068) = 1.88, p = 0.060; Std.
## beta = 0.65, 95% CI [-0.03, 1.33])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-5.99, 9.95], t(2068) = 0.49, p = 0.627; Std.
## beta = 0.24, 95% CI [-0.74, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-7.91, 7.69], t(2068) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.98, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.60, 95% CI [-57.08, 35.89], t(2068) = -0.45, p = 0.655;
## Std. beta = -1.31, 95% CI [-7.07, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.43, 26.15], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.65, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-5.98, 4.56], t(2068) = -0.27, p = 0.791; Std.
## beta = -0.09, 95% CI [-0.74, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.95, 15.00], t(2068) = -0.81, p = 0.420;
## Std. beta = -1.30, 95% CI [-4.45, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-6.33, 12.96], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.41, 95% CI [-0.78, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-5.34, 8.21], t(2068) = 0.41, p = 0.678; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.54, 95% CI [-3.80, 14.87], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.69, 95% CI [-0.47, 1.84])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-0.83, 10.21], t(2068) = 1.67, p = 0.096; Std.
## beta = 0.58, 95% CI [-0.10, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-11.20, 9.97], t(2068) = -0.11, p = 0.910; Std.
## beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-7.92, 2.16], t(2068) = -1.12, p = 0.263; Std.
## beta = -0.36, 95% CI [-0.98, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.72, 4.06], t(2068) = -0.61, p = 0.542; Std.
## beta = -0.23, 95% CI [-0.96, 0.50])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.33, 95% CI [-34.98, 16.32], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-12.42, 7.69], t(2068) = -0.46, p = 0.645; Std.
## beta = -0.29, 95% CI [-1.54, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.20, 5.96], t(2068) = 0.90, p = 0.366; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-7.87, 6.13], t(2068) = -0.24, p = 0.807; Std.
## beta = -0.11, 95% CI [-0.98, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-10.33, 4.59], t(2068) = -0.76, p = 0.450; Std.
## beta = -0.36, 95% CI [-1.28, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-3.46, 6.15], t(2068) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.06, 18.48], t(2068) = 1.97, p = 0.049; Std.
## beta = 1.15, 95% CI [6.95e-03, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.40, 11.36], t(2068) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-6.85, 4.44], t(2068) = -0.42, p = 0.675; Std.
## beta = -0.15, 95% CI [-0.85, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-5.46, 2.28], t(2068) = -0.81, p = 0.420; Std.
## beta = -0.20, 95% CI [-0.68, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.45, 95% CI [-49.98, -8.92], t(2068) = -2.81, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.10])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-6.70, 11.44], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.29, 95% CI [-0.83, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.07, 95% CI [-9.03, 17.17], t(2068) = 0.61, p = 0.543; Std.
## beta = 0.50, 95% CI [-1.12, 2.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-14.28, 9.02], t(2068) = -0.44, p = 0.658; Std.
## beta = -0.33, 95% CI [-1.77, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to cohort = CARE-PF, is at 47.76 (95% CI [40.54, 54.97], t(2068)
## = 12.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.33, 95% CI [-9.88, -2.78], t(2068) = -3.49, p < .001; Std. beta = -0.59, 95%
## CI [-0.73, -0.44])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.65, 95% CI [-1.26, -0.05], t(2068) = -2.11, p = 0.035; Std. beta = -0.07,
## 95% CI [-0.20, 0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-29.94, 23.33], t(2068) = -0.24, p = 0.808; Std. beta = -3.76,
## 95% CI [-7.17, -0.36])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.19, 95% CI [3.69, 42.68], t(2068) = 2.33, p = 0.020; Std. beta = 1.51, 95%
## CI [0.23, 2.78])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.60, 95% CI [-24.79, 11.60], t(2068) = -0.71, p = 0.477; Std. beta = -0.61,
## 95% CI [-2.05, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.16, 95% CI [-29.44, 1.13], t(2068) = -1.82, p = 0.069; Std. beta = -1.30,
## 95% CI [-2.79, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.25, 95% CI [-14.71, 23.20], t(2068) = 0.44, p = 0.660; Std. beta = 0.62,
## 95% CI [-0.74, 1.98])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.39, 95% CI [-4.15, 10.94], t(2068) = 0.88, p = 0.378; Std. beta = 6.82e-03,
## 95% CI [-0.48, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.88, 95% CI [-29.49, 7.72], t(2068) = -1.15, p = 0.252; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.40, 95% CI [11.73, 23.08], t(2068) = 6.02, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.54])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.30, 95% CI [-5.02, 15.63], t(2068) = 1.01, p = 0.314; Std. beta = 0.29, 95%
## CI [-0.40, 0.98])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -5.01, 95% CI [-10.33, 0.30], t(2068) = -1.85, p = 0.065; Std. beta = -0.13,
## 95% CI [-0.50, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.27, 95% CI [-24.09, -2.44], t(2068) = -2.40, p = 0.016; Std. beta = -0.57,
## 95% CI [-1.47, 0.33])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-6.65, 4.58], t(2068) = -0.36, p = 0.717; Std. beta = -0.03,
## 95% CI [-0.41, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.64, 95% CI [-12.56, 1.28], t(2068) = -1.60, p = 0.110; Std. beta = -0.20,
## 95% CI [-0.66, 0.26])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.62, 95% CI [-11.41, 26.64], t(2068) = 0.79, p = 0.432; Std. beta = -0.79,
## 95% CI [-2.43, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -11.52, 95% CI [-26.69, 3.65], t(2068) = -1.49, p = 0.137; Std. beta = -0.30,
## 95% CI [-1.29, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.57, 95% CI [-28.83, 23.69], t(2068) = -0.19, p = 0.848; Std. beta = -0.17,
## 95% CI [-1.96, 1.61])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-13.03, 9.64], t(2068) = -0.29, p = 0.769; Std. beta = 0.42,
## 95% CI [-0.37, 1.22])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-30.56, 6.57], t(2068) = -1.27, p = 0.205; Std. beta = -0.61,
## 95% CI [-1.90, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.97, 95% CI [-26.44, 2.49], t(2068) = -1.62, p = 0.105; Std. beta = -0.83,
## 95% CI [-1.79, 0.14])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.47, 95% CI [-37.92, 20.97], t(2068) = -0.56, p = 0.573; Std. beta = -1.67,
## 95% CI [-5.08, 1.75])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -25.30, 95% CI [-52.08, 1.49], t(2068) = -1.85, p = 0.064; Std. beta = -1.89,
## 95% CI [-4.52, 0.74])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.94, 1.47], t(2068) = -1.72, p = 0.086; Std. beta = -0.77,
## 95% CI [-1.58, 0.05])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.89, 95% CI [31.12, 84.66], t(2068) = 4.24, p < .001; Std. beta = 3.94, 95%
## CI [2.12, 5.76])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.21, 95% CI [-25.17, 12.75], t(2068) = -0.64, p = 0.521; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.27, 95% CI [-21.90, 3.37], t(2068) = -1.44, p = 0.151; Std. beta = -0.29,
## 95% CI [-1.36, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.18, 95% CI [-16.35, 5.98], t(2068) = -0.91, p = 0.363; Std. beta = -0.21,
## 95% CI [-1.03, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.51, 95% CI [-38.43, 11.40], t(2068) = -1.06, p = 0.288; Std. beta =
## -0.35, 95% CI [-1.93, 1.23])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.58, 95% CI [-21.07, -4.09], t(2068) = -2.91, p = 0.004; Std. beta = -0.37,
## 95% CI [-1.02, 0.27])
## - The effect of site [23R] is statistically significant and negative (beta =
## -20.46, 95% CI [-32.60, -8.32], t(2068) = -3.30, p < .001; Std. beta = -1.45,
## 95% CI [-2.62, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -0.26, 95% CI [-10.47, 9.95], t(2068) = -0.05, p = 0.960; Std. beta = -0.31,
## 95% CI [-1.01, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-18.28, 3.66], t(2068) = -1.31, p = 0.192; Std. beta = -0.69,
## 95% CI [-1.44, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.94, 95% CI [-33.46, -2.42], t(2068) = -2.27, p = 0.023; Std. beta = -2.18,
## 95% CI [-4.75, 0.39])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.08, 95% CI [-28.29, 24.13], t(2068) = -0.16, p = 0.876; Std. beta = -0.38,
## 95% CI [-2.00, 1.23])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.50, 95% CI [-14.15, 9.15], t(2068) = -0.42, p = 0.674; Std. beta = 0.02,
## 95% CI [-0.72, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.27, 95% CI [-9.96, 16.50], t(2068) = 0.48, p = 0.628; Std. beta = 0.13, 95%
## CI [-0.80, 1.06])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.33, 95% CI [-23.42, 2.76], t(2068) = -1.55, p = 0.122; Std. beta = -1.00,
## 95% CI [-1.99, -1.43e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.20, 95% CI [-17.31, 2.92], t(2068) = -1.39, p = 0.163; Std. beta = -0.35,
## 95% CI [-1.04, 0.34])
## - The effect of site [35R] is statistically significant and negative (beta =
## -16.76, 95% CI [-32.49, -1.03], t(2068) = -2.09, p = 0.037; Std. beta = -0.19,
## 95% CI [-1.31, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 1.69, 95% CI [-10.15, 13.53], t(2068) = 0.28, p = 0.779; Std. beta = 0.68,
## 95% CI [-0.16, 1.52])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.23, 95% CI [-12.63, 13.08], t(2068) = 0.03, p = 0.972; Std. beta = -0.11,
## 95% CI [-0.96, 0.74])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-12.74, 5.22], t(2068) = -0.82, p = 0.411; Std. beta = -0.42,
## 95% CI [-1.01, 0.18])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 3.23, 95% CI [-23.00, 29.46], t(2068) = 0.24, p = 0.809; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.86, 95% CI [-17.36, 19.07], t(2068) = 0.09, p = 0.927; Std. beta = 0.30,
## 95% CI [-1.02, 1.62])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.38, 95% CI [-30.64, -0.11], t(2068) = -1.98, p = 0.048; Std. beta = -0.63,
## 95% CI [-2.00, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.04, 95% CI [-18.67, -1.40], t(2068) = -2.28, p = 0.023; Std. beta = -0.95,
## 95% CI [-2.04, 0.14])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.18, 95% CI [-0.13, 0.49], t(2068) =
## 1.16, p = 0.245; Std. beta = 0.06, 95% CI [-0.04, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.44, 95% CI [-70.82, 1.94], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.27, 95% CI [-8.77, 0.24])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.69, 95% CI [-12.38, 11.01], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.08, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-13.84, 10.76], t(2068) = -0.25, p = 0.806;
## Std. beta = -0.19, 95% CI [-1.71, 1.33])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.24, 95% CI [-18.09, 11.60], t(2068) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.24, 1.44])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.23, 95% CI [-6.67, 13.13], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.13, 0.78], t(2068) = -1.45, p = 0.148; Std.
## beta = -0.27, 95% CI [-0.64, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-6.89, 9.78], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.18, 95% CI [-0.85, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.34, 95% CI [-2.78, 2.11], t(2068) = -0.27, p = 0.788; Std.
## beta = -0.04, 95% CI [-0.34, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-5.28, 3.89], t(2068) = -0.30, p = 0.766; Std.
## beta = -0.09, 95% CI [-0.65, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.04, 95% CI [-0.40, 4.48], t(2068) = 1.64, p = 0.101; Std.
## beta = 0.25, 95% CI [-0.05, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-4.24, 10.72], t(2068) = 0.85, p = 0.396; Std.
## beta = 0.40, 95% CI [-0.53, 1.33])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.43, 95% CI [-2.04, 2.91], t(2068) = 0.34, p = 0.731; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-1.52, 5.15], t(2068) = 1.07, p = 0.286; Std.
## beta = 0.22, 95% CI [-0.19, 0.64])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.74, 95% CI [-28.81, 3.33], t(2068) = -1.55, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.19, 11.58], t(2068) = 1.34, p = 0.181; Std.
## beta = 0.58, 95% CI [-0.27, 1.43])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.24, 95% CI [-0.23, 10.70], t(2068) = 1.88, p = 0.060; Std.
## beta = 0.65, 95% CI [-0.03, 1.33])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.98, 95% CI [-5.99, 9.95], t(2068) = 0.49, p = 0.627; Std.
## beta = 0.24, 95% CI [-0.74, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-7.91, 7.69], t(2068) = -0.03, p = 0.978; Std.
## beta = -0.01, 95% CI [-0.98, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.60, 95% CI [-57.08, 35.89], t(2068) = -0.45, p = 0.655;
## Std. beta = -1.31, 95% CI [-7.07, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.43, 26.15], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.65, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-5.98, 4.56], t(2068) = -0.27, p = 0.791; Std.
## beta = -0.09, 95% CI [-0.74, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.47, 95% CI [-35.95, 15.00], t(2068) = -0.81, p = 0.420;
## Std. beta = -1.30, 95% CI [-4.45, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.31, 95% CI [-6.33, 12.96], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.41, 95% CI [-0.78, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-5.34, 8.21], t(2068) = 0.41, p = 0.678; Std.
## beta = 0.18, 95% CI [-0.66, 1.02])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.54, 95% CI [-3.80, 14.87], t(2068) = 1.16, p = 0.245; Std.
## beta = 0.69, 95% CI [-0.47, 1.84])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-0.83, 10.21], t(2068) = 1.67, p = 0.096; Std.
## beta = 0.58, 95% CI [-0.10, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.61, 95% CI [-11.20, 9.97], t(2068) = -0.11, p = 0.910; Std.
## beta = -0.08, 95% CI [-1.39, 1.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.88, 95% CI [-7.92, 2.16], t(2068) = -1.12, p = 0.263; Std.
## beta = -0.36, 95% CI [-0.98, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-7.72, 4.06], t(2068) = -0.61, p = 0.542; Std.
## beta = -0.23, 95% CI [-0.96, 0.50])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.33, 95% CI [-34.98, 16.32], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.36, 95% CI [-12.42, 7.69], t(2068) = -0.46, p = 0.645; Std.
## beta = -0.29, 95% CI [-1.54, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.20, 5.96], t(2068) = 0.90, p = 0.366; Std.
## beta = 0.23, 95% CI [-0.27, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.87, 95% CI [-7.87, 6.13], t(2068) = -0.24, p = 0.807; Std.
## beta = -0.11, 95% CI [-0.98, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.87, 95% CI [-10.33, 4.59], t(2068) = -0.76, p = 0.450; Std.
## beta = -0.36, 95% CI [-1.28, 0.57])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-3.46, 6.15], t(2068) = 0.55, p = 0.584; Std.
## beta = 0.17, 95% CI [-0.43, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.27, 95% CI [0.06, 18.48], t(2068) = 1.97, p = 0.049; Std.
## beta = 1.15, 95% CI [6.95e-03, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.40, 11.36], t(2068) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-6.85, 4.44], t(2068) = -0.42, p = 0.675; Std.
## beta = -0.15, 95% CI [-0.85, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.59, 95% CI [-5.46, 2.28], t(2068) = -0.81, p = 0.420; Std.
## beta = -0.20, 95% CI [-0.68, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.45, 95% CI [-49.98, -8.92], t(2068) = -2.81, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.10])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.37, 95% CI [-6.70, 11.44], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.29, 95% CI [-0.83, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.07, 95% CI [-9.03, 17.17], t(2068) = 0.61, p = 0.543; Std.
## beta = 0.50, 95% CI [-1.12, 2.13])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.63, 95% CI [-14.28, 9.02], t(2068) = -0.44, p = 0.658; Std.
## beta = -0.33, 95% CI [-1.77, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*PM_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14894.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1124 -0.4921 -0.0077 0.4486 7.0938
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 136.84 11.698
## time_firstPFT 11.00 3.316 -0.28
## Residual 41.89 6.472
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 45.88953 5.93128 7.737
## time_firstPFT -4.38696 2.84619 -1.541
## PM_5yrPreCensor -0.74417 0.31691 -2.348
## disadv -5.87782 2.32898 -2.524
## dich_RaceNon-White -2.41445 2.28724 -1.056
## sexF -2.34314 1.41059 -1.661
## age_dx 0.14357 0.07367 1.949
## smokeHxFormer -2.77669 1.40292 -1.979
## smokeHxAlways 12.07414 7.09917 1.701
## smokeHxUnknown -2.07052 3.18604 -0.650
## site02R -7.47707 13.43559 -0.557
## site03R 18.36445 9.91557 1.852
## site04R -6.30189 9.13589 -0.690
## site05R -14.77080 7.71281 -1.915
## site06R -8.57083 13.42814 -0.638
## site07R 1.23583 3.82204 0.323
## site09R -13.67525 9.38817 -1.457
## site101 17.06355 2.89353 5.897
## site102 3.52354 5.26140 0.670
## site103 -5.62966 2.84752 -1.977
## site104 -12.85602 5.49720 -2.339
## site105 -0.90127 2.85316 -0.316
## site106 -8.18074 3.57792 -2.286
## site107 4.63014 9.59458 0.483
## site108 -7.35646 8.02524 -0.917
## site10R -2.15941 13.37852 -0.161
## site11R -2.99024 5.71411 -0.523
## site12R -11.08712 9.33324 -1.188
## site13R -14.01093 7.31397 -1.916
## site14R -10.94307 14.95474 -0.732
## site15R -22.12748 13.51001 -1.638
## site16R -10.45307 5.98623 -1.746
## site17R 61.88119 13.58057 4.557
## site18R -4.78641 9.56422 -0.500
## site19R -11.19972 6.41688 -1.745
## site20R -5.94853 5.63683 -1.055
## site21R -13.30986 12.48760 -1.066
## site22R -15.55369 4.35311 -3.573
## site23R -27.25663 7.70443 -3.538
## site24R -1.22699 5.14006 -0.239
## site25R -10.24075 5.59574 -1.830
## site28R -16.66729 7.85563 -2.122
## site29R -6.37169 13.22072 -0.482
## site31R -3.84298 5.94514 -0.646
## site32R 2.96397 6.70005 0.442
## site33R -11.21250 6.60843 -1.697
## site34R -7.63841 5.09573 -1.499
## site35R -18.09608 7.95632 -2.274
## site36R 0.92284 5.97725 0.154
## site37R -1.96385 6.55390 -0.300
## site38R -3.59571 4.52366 -0.795
## site39R 10.00843 13.44746 0.744
## site40R -0.72436 9.17033 -0.079
## site41R -16.79095 7.75241 -2.166
## site42R -12.27426 4.40104 -2.789
## time_firstPFT:PM_5yrPreCensor 0.14657 0.16448 0.891
## time_firstPFT:disadv 1.57755 1.10587 1.427
## time_firstPFT:dich_RaceNon-White -0.65620 1.11551 -0.588
## time_firstPFT:sexF 0.69593 0.65549 1.062
## time_firstPFT:age_dx -0.04047 0.03426 -1.181
## time_firstPFT:smokeHxFormer -0.62332 0.67248 -0.927
## time_firstPFT:smokeHxAlways -7.20927 6.06712 -1.188
## time_firstPFT:smokeHxUnknown 2.05344 1.68442 1.219
## time_firstPFT:site02R -32.71234 18.57002 -1.762
## time_firstPFT:site03R -0.25753 6.00643 -0.043
## time_firstPFT:site04R -2.26265 6.30176 -0.359
## time_firstPFT:site05R -3.14066 7.58493 -0.414
## time_firstPFT:site07R -1.62818 1.54119 -1.056
## time_firstPFT:site09R 2.50831 4.26641 0.588
## time_firstPFT:site101 -0.26089 1.26385 -0.206
## time_firstPFT:site102 -0.16546 2.36526 -0.070
## time_firstPFT:site103 2.25828 1.31715 1.715
## time_firstPFT:site104 2.63735 3.87284 0.681
## time_firstPFT:site105 0.43796 1.26731 0.346
## time_firstPFT:site106 2.35692 1.74531 1.350
## time_firstPFT:site107 -11.93898 8.20837 -1.454
## time_firstPFT:site108 5.27163 3.71954 1.417
## time_firstPFT:site11R 5.92671 2.83300 2.092
## time_firstPFT:site12R 2.37952 4.07507 0.584
## time_firstPFT:site13R -0.05450 4.00834 -0.014
## time_firstPFT:site14R -9.40431 23.72512 -0.396
## time_firstPFT:site15R -2.02876 14.18533 -0.143
## time_firstPFT:site16R -0.88136 2.74215 -0.321
## time_firstPFT:site18R -10.38705 13.00366 -0.799
## time_firstPFT:site19R 3.24263 4.98838 0.650
## time_firstPFT:site20R 1.22843 3.50164 0.351
## time_firstPFT:site21R 6.10609 4.75648 1.284
## time_firstPFT:site22R 5.92160 2.85999 2.070
## time_firstPFT:site23R 22.99806 26.72871 0.860
## time_firstPFT:site24R -2.61657 2.57325 -1.017
## time_firstPFT:site25R -0.84112 3.06294 -0.275
## time_firstPFT:site28R -8.56072 13.16100 -0.650
## time_firstPFT:site29R -0.75706 5.16113 -0.147
## time_firstPFT:site31R 2.59623 2.13729 1.215
## time_firstPFT:site32R -0.33484 3.60540 -0.093
## time_firstPFT:site33R -3.39875 3.85636 -0.881
## time_firstPFT:site34R 1.37923 2.47437 0.557
## time_firstPFT:site35R 9.99826 4.73451 2.112
## time_firstPFT:site36R 5.51440 3.01560 1.829
## time_firstPFT:site37R -0.75381 2.98860 -0.252
## time_firstPFT:site38R -1.57746 1.98103 -0.796
## time_firstPFT:site39R -29.67417 10.55288 -2.812
## time_firstPFT:site40R 1.86065 4.67697 0.398
## time_firstPFT:site41R 4.92589 6.70403 0.735
## time_firstPFT:site42R -2.93877 5.95709 -0.493##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.799
## Unadjusted ICC: 0.522report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## PM_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.35. The model's intercept,
## corresponding to time_firstPFT = 0, is at 45.89 (95% CI [34.26, 57.52], t(2038)
## = 7.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## PM_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to
## PM_5yrPreCensor = 0, is at 45.89 (95% CI [34.26, 57.52], t(2038) = 7.74, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to disadv = 0, is at 45.89 (95% CI [34.26,
## 57.52], t(2038) = 7.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to dich_Race =
## White, is at 45.89 (95% CI [34.26, 57.52], t(2038) = 7.74, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to sex = M, is at 45.89 (95% CI [34.26,
## 57.52], t(2038) = 7.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to age_dx = 0, is at 45.89 (95% CI [34.26,
## 57.52], t(2038) = 7.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to smokeHx =
## Never, is at 45.89 (95% CI [34.26, 57.52], t(2038) = 7.74, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to site = Simmons, is at 45.89 (95% CI [34.26,
## 57.52], t(2038) = 7.74, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * PM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to cohort =
## CARE-PF, is at 45.89 (95% CI [34.26, 57.52], t(2038) = 7.74, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.39, 95% CI [-9.97, 1.19], t(2038) = -1.54, p = 0.123; Std. beta =
## -0.59, 95% CI [-0.80, -0.38])
## - The effect of PM 5yrPreCensor is statistically significant and negative (beta
## = -0.74, 95% CI [-1.37, -0.12], t(2038) = -2.35, p = 0.019; Std. beta = -0.10,
## 95% CI [-0.23, 0.03])
## - The effect of disadv is statistically significant and negative (beta = -5.88,
## 95% CI [-10.45, -1.31], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.41, 95% CI [-6.90, 2.07], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.23, 95% CI [-0.55, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.11, 0.42], t(2038) = -1.66, p = 0.097; Std. beta = -0.09, 95%
## CI [-0.28, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.06e-04, 0.29], t(2038) = 1.95, p = 0.051; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.78, 95% CI [-5.53, -0.03], t(2038) = -1.98, p = 0.048; Std. beta =
## -0.25, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 12.07, 95% CI [-1.85, 26.00], t(2038) = 1.70, p = 0.089; Std. beta =
## 0.08, 95% CI [-1.18, 1.33])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.07, 95% CI [-8.32, 4.18], t(2038) = -0.65, p = 0.516; Std. beta =
## 0.07, 95% CI [-0.39, 0.53])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-33.83, 18.87], t(2038) = -0.56, p = 0.578; Std. beta = -3.88,
## 95% CI [-7.30, -0.47])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 18.36, 95% CI [-1.08, 37.81], t(2038) = 1.85, p = 0.064; Std. beta = 1.22,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.30, 95% CI [-24.22, 11.61], t(2038) = -0.69, p = 0.490; Std. beta = -0.66,
## 95% CI [-2.11, 0.78])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.77, 95% CI [-29.90, 0.36], t(2038) = -1.92, p = 0.056; Std. beta = -1.33,
## 95% CI [-2.83, 0.17])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-34.91, 17.76], t(2038) = -0.64, p = 0.523; Std. beta = -0.58,
## 95% CI [-2.37, 1.21])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.24, 95% CI [-6.26, 8.73], t(2038) = 0.32, p = 0.746; Std. beta = -0.08, 95%
## CI [-0.58, 0.41])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.68, 95% CI [-32.09, 4.74], t(2038) = -1.46, p = 0.145; Std. beta = -0.67,
## 95% CI [-1.95, 0.61])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.06, 95% CI [11.39, 22.74], t(2038) = 5.90, p < .001; Std. beta = 1.13, 95%
## CI [0.74, 1.52])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.52, 95% CI [-6.79, 13.84], t(2038) = 0.67, p = 0.503; Std. beta = 0.22, 95%
## CI [-0.48, 0.92])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.63, 95% CI [-11.21, -0.05], t(2038) = -1.98, p = 0.048; Std. beta = -0.15,
## 95% CI [-0.54, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.86, 95% CI [-23.64, -2.08], t(2038) = -2.34, p = 0.019; Std. beta = -0.60,
## 95% CI [-1.51, 0.31])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.90, 95% CI [-6.50, 4.69], t(2038) = -0.32, p = 0.752; Std. beta = -0.02,
## 95% CI [-0.40, 0.37])
## - The effect of site [106] is statistically significant and negative (beta =
## -8.18, 95% CI [-15.20, -1.16], t(2038) = -2.29, p = 0.022; Std. beta = -0.31,
## 95% CI [-0.79, 0.16])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.63, 95% CI [-14.19, 23.45], t(2038) = 0.48, p = 0.629; Std. beta = -0.92,
## 95% CI [-2.56, 0.73])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-23.09, 8.38], t(2038) = -0.92, p = 0.359; Std. beta = 0.04,
## 95% CI [-1.01, 1.10])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.16, 95% CI [-28.40, 24.08], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.93, 1.64])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-14.20, 8.22], t(2038) = -0.52, p = 0.601; Std. beta = 0.41,
## 95% CI [-0.39, 1.21])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.09, 95% CI [-29.39, 7.22], t(2038) = -1.19, p = 0.235; Std. beta = -0.51,
## 95% CI [-1.79, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.01, 95% CI [-28.35, 0.33], t(2038) = -1.92, p = 0.056; Std. beta = -0.96,
## 95% CI [-1.93, 0.01])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.94, 95% CI [-40.27, 18.39], t(2038) = -0.73, p = 0.464; Std. beta =
## -1.71, 95% CI [-5.15, 1.72])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.13, 95% CI [-48.62, 4.37], t(2038) = -1.64, p = 0.102; Std. beta = -1.71,
## 95% CI [-4.35, 0.92])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-22.19, 1.29], t(2038) = -1.75, p = 0.081; Std. beta = -0.80,
## 95% CI [-1.63, 0.03])
## - The effect of site [17R] is statistically significant and positive (beta =
## 61.88, 95% CI [35.25, 88.51], t(2038) = 4.56, p < .001; Std. beta = 4.20, 95%
## CI [2.40, 6.01])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.79, 95% CI [-23.54, 13.97], t(2038) = -0.50, p = 0.617; Std. beta = -1.40,
## 95% CI [-3.93, 1.13])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.20, 95% CI [-23.78, 1.38], t(2038) = -1.75, p = 0.081; Std. beta = -0.43,
## 95% CI [-1.52, 0.66])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.95, 95% CI [-17.00, 5.11], t(2038) = -1.06, p = 0.291; Std. beta = -0.28,
## 95% CI [-1.11, 0.56])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -13.31, 95% CI [-37.80, 11.18], t(2038) = -1.07, p = 0.287; Std. beta =
## -0.27, 95% CI [-1.85, 1.30])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.55, 95% CI [-24.09, -7.02], t(2038) = -3.57, p < .001; Std. beta = -0.45,
## 95% CI [-1.10, 0.21])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.26, 95% CI [-42.37, -12.15], t(2038) = -3.54, p < .001; Std. beta = 0.52,
## 95% CI [-4.47, 5.51])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.23, 95% CI [-11.31, 8.85], t(2038) = -0.24, p = 0.811; Std. beta = -0.35,
## 95% CI [-1.05, 0.34])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.24, 95% CI [-21.21, 0.73], t(2038) = -1.83, p = 0.067; Std. beta = -0.78,
## 95% CI [-1.55, -0.01])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.67, 95% CI [-32.07, -1.26], t(2038) = -2.12, p = 0.034; Std. beta = -2.02,
## 95% CI [-4.61, 0.58])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-32.30, 19.56], t(2038) = -0.48, p = 0.630; Std. beta = -0.51,
## 95% CI [-2.13, 1.10])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.84, 95% CI [-15.50, 7.82], t(2038) = -0.65, p = 0.518; Std. beta =
## 6.62e-03, 95% CI [-0.75, 0.76])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-10.18, 16.10], t(2038) = 0.44, p = 0.658; Std. beta = 0.17,
## 95% CI [-0.77, 1.10])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.21, 95% CI [-24.17, 1.75], t(2038) = -1.70, p = 0.090; Std. beta = -1.11,
## 95% CI [-2.12, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.64, 95% CI [-17.63, 2.35], t(2038) = -1.50, p = 0.134; Std. beta = -0.38,
## 95% CI [-1.07, 0.32])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.10, 95% CI [-33.70, -2.49], t(2038) = -2.27, p = 0.023; Std. beta = -0.20,
## 95% CI [-1.32, 0.93])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-10.80, 12.65], t(2038) = 0.15, p = 0.877; Std. beta = 0.63,
## 95% CI [-0.21, 1.48])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.96, 95% CI [-14.82, 10.89], t(2038) = -0.30, p = 0.764; Std. beta = -0.21,
## 95% CI [-1.08, 0.66])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.60, 95% CI [-12.47, 5.28], t(2038) = -0.79, p = 0.427; Std. beta = -0.41,
## 95% CI [-1.00, 0.19])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.01, 95% CI [-16.36, 36.38], t(2038) = 0.74, p = 0.457; Std. beta = -2.38,
## 95% CI [-4.58, -0.18])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -0.72, 95% CI [-18.71, 17.26], t(2038) = -0.08, p = 0.937; Std. beta = 0.14,
## 95% CI [-1.18, 1.47])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.79, 95% CI [-31.99, -1.59], t(2038) = -2.17, p = 0.030; Std. beta = -0.63,
## 95% CI [-2.01, 0.74])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.27, 95% CI [-20.91, -3.64], t(2038) = -2.79, p = 0.005; Std. beta = -1.14,
## 95% CI [-2.24, -0.04])
## - The effect of time firstPFT × PM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.18, 0.47], t(2038) =
## 0.89, p = 0.373; Std. beta = 0.05, 95% CI [-0.06, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.58, 95% CI [-0.59, 3.75], t(2038) = 1.43, p = 0.154; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.66, 95% CI [-2.84, 1.53], t(2038) =
## -0.59, p = 0.556; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.59, 1.98], t(2038) = 1.06, p = 0.288; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.18, p = 0.238; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.62, 95% CI [-1.94, 0.70], t(2038) =
## -0.93, p = 0.354; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -7.21, 95% CI [-19.11, 4.69], t(2038) =
## -1.19, p = 0.235; Std. beta = -0.89, 95% CI [-2.37, 0.58])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.05, 95% CI [-1.25, 5.36], t(2038) =
## 1.22, p = 0.223; Std. beta = 0.25, 95% CI [-0.16, 0.66])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.71, 95% CI [-69.13, 3.71], t(2038) = -1.76, p = 0.078;
## Std. beta = -4.06, 95% CI [-8.58, 0.46])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.04, 11.52], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-14.62, 10.10], t(2038) = -0.36, p = 0.720;
## Std. beta = -0.28, 95% CI [-1.81, 1.25])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-18.02, 11.73], t(2038) = -0.41, p = 0.679;
## Std. beta = -0.39, 95% CI [-2.24, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-4.65, 1.39], t(2038) = -1.06, p = 0.291; Std.
## beta = -0.20, 95% CI [-0.58, 0.17])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.51, 95% CI [-5.86, 10.88], t(2038) = 0.59, p = 0.557; Std.
## beta = 0.31, 95% CI [-0.73, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-2.74, 2.22], t(2038) = -0.21, p = 0.836; Std.
## beta = -0.03, 95% CI [-0.34, 0.28])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.17, 95% CI [-4.80, 4.47], t(2038) = -0.07, p = 0.944; Std.
## beta = -0.02, 95% CI [-0.60, 0.55])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.26, 95% CI [-0.32, 4.84], t(2038) = 1.71, p = 0.087; Std.
## beta = 0.28, 95% CI [-0.04, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.64, 95% CI [-4.96, 10.23], t(2038) = 0.68, p = 0.496; Std.
## beta = 0.33, 95% CI [-0.62, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-2.05, 2.92], t(2038) = 0.35, p = 0.730; Std.
## beta = 0.05, 95% CI [-0.25, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-1.07, 5.78], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.29, 95% CI [-0.13, 0.72])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-28.04, 4.16], t(2038) = -1.45, p = 0.146;
## Std. beta = -1.48, 95% CI [-3.48, 0.52])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-2.02, 12.57], t(2038) = 1.42, p = 0.157; Std.
## beta = 0.65, 95% CI [-0.25, 1.56])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.93, 95% CI [0.37, 11.48], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.74, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-5.61, 10.37], t(2038) = 0.58, p = 0.559; Std.
## beta = 0.30, 95% CI [-0.70, 1.29])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.05, 95% CI [-7.92, 7.81], t(2038) = -0.01, p = 0.989; Std.
## beta = -6.76e-03, 95% CI [-0.98, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.40, 95% CI [-55.93, 37.12], t(2038) = -0.40, p = 0.692;
## Std. beta = -1.17, 95% CI [-6.94, 4.61])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.03, 95% CI [-29.85, 25.79], t(2038) = -0.14, p = 0.886;
## Std. beta = -0.25, 95% CI [-3.70, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.26, 4.50], t(2038) = -0.32, p = 0.748; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.39, 95% CI [-35.89, 15.11], t(2038) = -0.80, p = 0.425;
## Std. beta = -1.29, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.54, 13.03], t(2038) = 0.65, p = 0.516; Std.
## beta = 0.40, 95% CI [-0.81, 1.62])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.23, 95% CI [-5.64, 8.10], t(2038) = 0.35, p = 0.726; Std.
## beta = 0.15, 95% CI [-0.70, 1.00])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.11, 95% CI [-3.22, 15.43], t(2038) = 1.28, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.91])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.31, 11.53], t(2038) = 2.07, p = 0.039; Std.
## beta = 0.73, 95% CI [0.04, 1.43])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.00, 95% CI [-29.42, 75.42], t(2038) = 0.86, p = 0.390; Std.
## beta = 2.85, 95% CI [-3.65, 9.36])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.66, 2.43], t(2038) = -1.02, p = 0.309; Std.
## beta = -0.32, 95% CI [-0.95, 0.30])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.85, 5.17], t(2038) = -0.27, p = 0.784; Std.
## beta = -0.10, 95% CI [-0.85, 0.64])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.56, 95% CI [-34.37, 17.25], t(2038) = -0.65, p = 0.515;
## Std. beta = -1.06, 95% CI [-4.26, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-10.88, 9.36], t(2038) = -0.15, p = 0.883; Std.
## beta = -0.09, 95% CI [-1.35, 1.16])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.60, 95% CI [-1.60, 6.79], t(2038) = 1.21, p = 0.225; Std.
## beta = 0.32, 95% CI [-0.20, 0.84])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-7.41, 6.74], t(2038) = -0.09, p = 0.926; Std.
## beta = -0.04, 95% CI [-0.92, 0.84])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.40, 95% CI [-10.96, 4.16], t(2038) = -0.88, p = 0.378; Std.
## beta = -0.42, 95% CI [-1.36, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-3.47, 6.23], t(2038) = 0.56, p = 0.577; Std.
## beta = 0.17, 95% CI [-0.43, 0.77])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.00, 95% CI [0.71, 19.28], t(2038) = 2.11, p = 0.035; Std.
## beta = 1.24, 95% CI [0.09, 2.39])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.51, 95% CI [-0.40, 11.43], t(2038) = 1.83, p = 0.068; Std.
## beta = 0.68, 95% CI [-0.05, 1.42])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.75, 95% CI [-6.61, 5.11], t(2038) = -0.25, p = 0.801; Std.
## beta = -0.09, 95% CI [-0.82, 0.63])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.58, 95% CI [-5.46, 2.31], t(2038) = -0.80, p = 0.426; Std.
## beta = -0.20, 95% CI [-0.68, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.67, 95% CI [-50.37, -8.98], t(2038) = -2.81, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.25, -1.11])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-7.31, 11.03], t(2038) = 0.40, p = 0.691; Std.
## beta = 0.23, 95% CI [-0.91, 1.37])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.93, 95% CI [-8.22, 18.07], t(2038) = 0.73, p = 0.463; Std.
## beta = 0.61, 95% CI [-1.02, 2.24])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.94, 95% CI [-14.62, 8.74], t(2038) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*SO4_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15065.5
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1332 -0.4904 -0.0036 0.4426 7.1159
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 142.92 11.955
## time_firstPFT 11.37 3.372 -0.32
## Residual 41.80 6.465
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 46.1023 2.8893 15.956
## time_firstPFT -5.0400 1.2677 -3.976
## SO4_5yrPreCensor -1.5915 0.7419 -2.145
## site02R -6.4582 13.7429 -0.470
## site03R 21.0531 10.1069 2.083
## site04R -8.8084 9.4113 -0.936
## site05R -15.2660 7.8680 -1.940
## site06R 2.1282 9.7585 0.218
## site07R 2.0368 4.0739 0.500
## site09R -12.2555 9.5960 -1.277
## site101 16.4724 3.1136 5.290
## site102 4.1438 5.4677 0.758
## site103 -6.5800 3.1829 -2.067
## site104 -14.3183 5.6993 -2.512
## site105 -2.2728 3.1756 -0.716
## site106 -6.8682 3.7434 -1.835
## site107 6.6102 9.7880 0.675
## site108 -12.4483 7.8530 -1.585
## site10R -4.4948 13.4428 -0.334
## site11R -3.4244 5.9437 -0.576
## site12R -13.0352 9.5614 -1.363
## site13R -13.1420 7.4824 -1.756
## site14R -9.8844 15.0738 -0.656
## site15R -26.7271 13.7298 -1.947
## site16R -11.7781 6.1382 -1.919
## site17R 56.3400 13.7212 4.106
## site18R -7.9020 9.7698 -0.809
## site19R -9.8760 6.5292 -1.513
## site20R -6.1722 5.8119 -1.062
## site21R -15.6790 12.7949 -1.225
## site22R -14.2180 4.5407 -3.131
## site23R -21.5792 6.2954 -3.428
## site24R -1.6155 5.4062 -0.299
## site25R -10.3088 5.9591 -1.730
## site28R -19.7136 8.0130 -2.460
## site29R -3.1897 13.4371 -0.237
## site31R -3.3411 6.0441 -0.553
## site32R 0.8992 7.0211 0.128
## site33R -11.1604 6.7489 -1.654
## site34R -8.1265 5.2862 -1.537
## site35R -17.3940 8.0933 -2.149
## site36R 0.5241 6.1551 0.085
## site37R -1.4829 6.7201 -0.221
## site38R -4.8727 4.7367 -1.029
## site39R 1.9785 13.4690 0.147
## site40R -2.2728 9.4914 -0.239
## site41R -16.9886 7.9271 -2.143
## site42R -11.5827 4.5912 -2.523
## time_firstPFT:SO4_5yrPreCensor 0.2129 0.3389 0.628
## time_firstPFT:site02R -34.2234 18.5687 -1.843
## time_firstPFT:site03R -0.7738 6.0192 -0.129
## time_firstPFT:site04R -1.4749 6.3122 -0.234
## time_firstPFT:site05R -3.3560 7.5805 -0.443
## time_firstPFT:site06R 3.4375 5.0927 0.675
## time_firstPFT:site07R -2.3364 1.6035 -1.457
## time_firstPFT:site09R 1.3017 4.3089 0.302
## time_firstPFT:site101 -0.5948 1.3178 -0.451
## time_firstPFT:site102 -1.0800 2.4067 -0.449
## time_firstPFT:site103 1.7776 1.3912 1.278
## time_firstPFT:site104 2.8483 3.8643 0.737
## time_firstPFT:site105 0.1788 1.3630 0.131
## time_firstPFT:site106 1.6172 1.7638 0.917
## time_firstPFT:site107 -13.0831 8.2109 -1.593
## time_firstPFT:site108 4.2175 3.5381 1.192
## time_firstPFT:site11R 5.2687 2.8593 1.843
## time_firstPFT:site12R 1.7111 4.1229 0.415
## time_firstPFT:site13R -0.2659 4.0196 -0.066
## time_firstPFT:site14R -10.7162 23.7013 -0.452
## time_firstPFT:site15R -1.7524 14.1820 -0.124
## time_firstPFT:site16R -0.8802 2.7564 -0.319
## time_firstPFT:site18R -10.5034 12.9982 -0.808
## time_firstPFT:site19R 2.8150 4.9313 0.571
## time_firstPFT:site20R 1.1719 3.4814 0.337
## time_firstPFT:site21R 5.6774 4.8201 1.178
## time_firstPFT:site22R 4.6184 2.8687 1.610
## time_firstPFT:site23R -0.7570 5.4168 -0.140
## time_firstPFT:site24R -3.1365 2.6360 -1.190
## time_firstPFT:site25R -1.7469 3.1218 -0.560
## time_firstPFT:site28R -9.2111 13.0829 -0.704
## time_firstPFT:site29R -2.6564 5.1685 -0.514
## time_firstPFT:site31R 1.5506 2.1164 0.733
## time_firstPFT:site32R -0.8430 3.6817 -0.229
## time_firstPFT:site33R -3.1479 3.8271 -0.823
## time_firstPFT:site34R 1.0767 2.5056 0.430
## time_firstPFT:site35R 8.7507 4.6981 1.863
## time_firstPFT:site36R 5.2990 3.0432 1.741
## time_firstPFT:site37R -1.2126 2.9603 -0.410
## time_firstPFT:site38R -1.7799 2.0326 -0.876
## time_firstPFT:site39R -29.8260 10.4894 -2.843
## time_firstPFT:site40R 2.3602 4.6757 0.505
## time_firstPFT:site41R 3.9392 6.7108 0.587
## time_firstPFT:site42R -2.6701 5.9609 -0.448##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.801
## Unadjusted ICC: 0.531report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SO4_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.34. The model's
## intercept, corresponding to time_firstPFT = 0, is at 46.10 (95% CI [40.44,
## 51.77], t(2068) = 15.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.04, 95% CI [-7.53, -2.55], t(2068) = -3.98, p < .001; Std. beta = -0.57, 95%
## CI [-0.74, -0.41])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.59, 95% CI [-3.05, -0.14], t(2068) = -2.14, p = 0.032; Std. beta =
## -0.13, 95% CI [-0.29, 0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-33.41, 20.49], t(2068) = -0.47, p = 0.638; Std. beta = -3.96,
## 95% CI [-7.37, -0.55])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.05, 95% CI [1.23, 40.87], t(2068) = 2.08, p = 0.037; Std. beta = 1.35, 95%
## CI [0.06, 2.65])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.81, 95% CI [-27.27, 9.65], t(2068) = -0.94, p = 0.349; Std. beta = -0.75,
## 95% CI [-2.20, 0.70])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -15.27, 95% CI [-30.70, 0.16], t(2068) = -1.94, p = 0.052; Std. beta = -1.38,
## 95% CI [-2.88, 0.11])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 2.13, 95% CI [-17.01, 21.27], t(2068) = 0.22, p = 0.827; Std. beta = 0.50,
## 95% CI [-0.87, 1.87])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.04, 95% CI [-5.95, 10.03], t(2068) = 0.50, p = 0.617; Std. beta = -0.10,
## 95% CI [-0.62, 0.42])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.26, 95% CI [-31.07, 6.56], t(2068) = -1.28, p = 0.202; Std. beta = -0.70,
## 95% CI [-1.99, 0.59])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.47, 95% CI [10.37, 22.58], t(2068) = 5.29, p < .001; Std. beta = 1.06, 95%
## CI [0.65, 1.47])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-6.58, 14.87], t(2068) = 0.76, p = 0.449; Std. beta = 0.17, 95%
## CI [-0.54, 0.88])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.58, 95% CI [-12.82, -0.34], t(2068) = -2.07, p = 0.039; Std. beta = -0.26,
## 95% CI [-0.69, 0.16])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.32, 95% CI [-25.50, -3.14], t(2068) = -2.51, p = 0.012; Std. beta = -0.68,
## 95% CI [-1.60, 0.23])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-8.50, 3.95], t(2068) = -0.72, p = 0.474; Std. beta = -0.14,
## 95% CI [-0.55, 0.28])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.87, 95% CI [-14.21, 0.47], t(2068) = -1.83, p = 0.067; Std. beta = -0.30,
## 95% CI [-0.79, 0.19])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-12.59, 25.81], t(2068) = 0.68, p = 0.500; Std. beta = -0.90,
## 95% CI [-2.54, 0.75])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-27.85, 2.95], t(2068) = -1.59, p = 0.113; Std. beta = -0.41,
## 95% CI [-1.42, 0.59])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-30.86, 21.87], t(2068) = -0.33, p = 0.738; Std. beta = -0.31,
## 95% CI [-2.10, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-15.08, 8.23], t(2068) = -0.58, p = 0.565; Std. beta = 0.31,
## 95% CI [-0.51, 1.12])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.79, 5.72], t(2068) = -1.36, p = 0.173; Std. beta = -0.71,
## 95% CI [-2.00, 0.58])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -13.14, 95% CI [-27.82, 1.53], t(2068) = -1.76, p = 0.079; Std. beta = -0.92,
## 95% CI [-1.90, 0.05])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-39.45, 19.68], t(2068) = -0.66, p = 0.512; Std. beta = -1.77,
## 95% CI [-5.19, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.73, 95% CI [-53.65, 0.20], t(2068) = -1.95, p = 0.052; Std. beta = -2.00,
## 95% CI [-4.63, 0.63])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -11.78, 95% CI [-23.82, 0.26], t(2068) = -1.92, p = 0.055; Std. beta = -0.89,
## 95% CI [-1.73, -0.06])
## - The effect of site [17R] is statistically significant and positive (beta =
## 56.34, 95% CI [29.43, 83.25], t(2068) = 4.11, p < .001; Std. beta = 3.83, 95%
## CI [2.00, 5.66])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.90, 95% CI [-27.06, 11.26], t(2068) = -0.81, p = 0.419; Std. beta = -1.62,
## 95% CI [-4.14, 0.91])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-22.68, 2.93], t(2068) = -1.51, p = 0.131; Std. beta = -0.38,
## 95% CI [-1.46, 0.70])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-17.57, 5.23], t(2068) = -1.06, p = 0.288; Std. beta = -0.30,
## 95% CI [-1.14, 0.54])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.68, 95% CI [-40.77, 9.41], t(2068) = -1.23, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.07, 1.10])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.22, 95% CI [-23.12, -5.31], t(2068) = -3.13, p = 0.002; Std. beta = -0.49,
## 95% CI [-1.16, 0.18])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.58, 95% CI [-33.93, -9.23], t(2068) = -3.43, p < .001; Std. beta = -1.55,
## 95% CI [-2.72, -0.37])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std. beta = -0.43,
## 95% CI [-1.15, 0.29])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-22.00, 1.38], t(2068) = -1.73, p = 0.084; Std. beta = -0.88,
## 95% CI [-1.68, -0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.71, 95% CI [-35.43, -4.00], t(2068) = -2.46, p = 0.014; Std. beta = -2.29,
## 95% CI [-4.86, 0.28])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-29.54, 23.16], t(2068) = -0.24, p = 0.812; Std. beta = -0.49,
## 95% CI [-2.11, 1.13])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-15.19, 8.51], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.82, 0.68])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-12.87, 14.67], t(2068) = 0.13, p = 0.898; Std. beta = -0.03,
## 95% CI [-0.99, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.16, 95% CI [-24.40, 2.07], t(2068) = -1.65, p = 0.098; Std. beta = -1.08,
## 95% CI [-2.08, -0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-18.49, 2.24], t(2068) = -1.54, p = 0.124; Std. beta = -0.44,
## 95% CI [-1.15, 0.26])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.39, 95% CI [-33.27, -1.52], t(2068) = -2.15, p = 0.032; Std. beta = -0.28,
## 95% CI [-1.41, 0.84])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-11.55, 12.59], t(2068) = 0.09, p = 0.932; Std. beta = 0.58,
## 95% CI [-0.27, 1.43])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.66, 11.70], t(2068) = -0.22, p = 0.825; Std. beta = -0.23,
## 95% CI [-1.10, 0.64])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-14.16, 4.42], t(2068) = -1.03, p = 0.304; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.44, 28.39], t(2068) = 0.15, p = 0.883; Std. beta = -2.93,
## 95% CI [-5.10, -0.76])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-20.89, 16.34], t(2068) = -0.24, p = 0.811; Std. beta = 0.09,
## 95% CI [-1.25, 1.42])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.99, 95% CI [-32.53, -1.44], t(2068) = -2.14, p = 0.032; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.58, 95% CI [-20.59, -2.58], t(2068) = -2.52, p = 0.012; Std. beta = -1.06,
## 95% CI [-2.17, 0.04])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.21, 95% CI [-0.45, 0.88], t(2068) =
## 0.63, p = 0.530; Std. beta = 0.04, 95% CI [-0.09, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.22, 95% CI [-70.64, 2.19], t(2068) = -1.84, p = 0.065;
## Std. beta = -4.24, 95% CI [-8.75, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.58, 11.03], t(2068) = -0.13, p = 0.898;
## Std. beta = -0.10, 95% CI [-1.56, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-13.85, 10.90], t(2068) = -0.23, p = 0.815;
## Std. beta = -0.18, 95% CI [-1.72, 1.35])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.36, 95% CI [-18.22, 11.51], t(2068) = -0.44, p = 0.658;
## Std. beta = -0.42, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-6.55, 13.42], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.43, 95% CI [-0.81, 1.66])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-5.48, 0.81], t(2068) = -1.46, p = 0.145; Std.
## beta = -0.29, 95% CI [-0.68, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-7.15, 9.75], t(2068) = 0.30, p = 0.763; Std.
## beta = 0.16, 95% CI [-0.89, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-3.18, 1.99], t(2068) = -0.45, p = 0.652; Std.
## beta = -0.07, 95% CI [-0.39, 0.25])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-5.80, 3.64], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.13, 95% CI [-0.72, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.78, 95% CI [-0.95, 4.51], t(2068) = 1.28, p = 0.201; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.73, 10.43], t(2068) = 0.74, p = 0.461; Std.
## beta = 0.35, 95% CI [-0.59, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-2.49, 2.85], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.02, 95% CI [-0.31, 0.35])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-1.84, 5.08], t(2068) = 0.92, p = 0.359; Std.
## beta = 0.20, 95% CI [-0.23, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.08, 95% CI [-29.19, 3.02], t(2068) = -1.59, p = 0.111;
## Std. beta = -1.62, 95% CI [-3.62, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-2.72, 11.16], t(2068) = 1.19, p = 0.233; Std.
## beta = 0.52, 95% CI [-0.34, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.34, 10.88], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.65, 95% CI [-0.04, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-6.37, 9.80], t(2068) = 0.42, p = 0.678; Std.
## beta = 0.21, 95% CI [-0.79, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.15, 7.62], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.01, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.72, 95% CI [-57.20, 35.76], t(2068) = -0.45, p = 0.651;
## Std. beta = -1.33, 95% CI [-7.09, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-29.56, 26.06], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.22, 95% CI [-3.66, 3.23])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.29, 4.53], t(2068) = -0.32, p = 0.750; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.50, 95% CI [-35.99, 14.99], t(2068) = -0.81, p = 0.419;
## Std. beta = -1.30, 95% CI [-4.46, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.86, 12.49], t(2068) = 0.57, p = 0.568; Std.
## beta = 0.35, 95% CI [-0.85, 1.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-5.66, 8.00], t(2068) = 0.34, p = 0.736; Std.
## beta = 0.15, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.68, 95% CI [-3.78, 15.13], t(2068) = 1.18, p = 0.239; Std.
## beta = 0.70, 95% CI [-0.47, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.01, 10.24], t(2068) = 1.61, p = 0.108; Std.
## beta = 0.57, 95% CI [-0.12, 1.27])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-11.38, 9.87], t(2068) = -0.14, p = 0.889; Std.
## beta = -0.09, 95% CI [-1.41, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-8.31, 2.03], t(2068) = -1.19, p = 0.234; Std.
## beta = -0.39, 95% CI [-1.03, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.87, 4.38], t(2068) = -0.56, p = 0.576; Std.
## beta = -0.22, 95% CI [-0.97, 0.54])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.21, 95% CI [-34.87, 16.45], t(2068) = -0.70, p = 0.481;
## Std. beta = -1.14, 95% CI [-4.32, 2.04])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.79, 7.48], t(2068) = -0.51, p = 0.607; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.60, 5.70], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.19, 95% CI [-0.32, 0.71])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-8.06, 6.38], t(2068) = -0.23, p = 0.819; Std.
## beta = -0.10, 95% CI [-1.00, 0.79])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-10.65, 4.36], t(2068) = -0.82, p = 0.411; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-3.84, 5.99], t(2068) = 0.43, p = 0.667; Std.
## beta = 0.13, 95% CI [-0.48, 0.74])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.75, 95% CI [-0.46, 17.96], t(2068) = 1.86, p = 0.063; Std.
## beta = 1.08, 95% CI [-0.06, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-0.67, 11.27], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.66, 95% CI [-0.08, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.02, 4.59], t(2068) = -0.41, p = 0.682; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.77, 2.21], t(2068) = -0.88, p = 0.381; Std.
## beta = -0.22, 95% CI [-0.71, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.83, 95% CI [-50.40, -9.26], t(2068) = -2.84, p = 0.005;
## Std. beta = -3.69, 95% CI [-6.24, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-6.81, 11.53], t(2068) = 0.50, p = 0.614; Std.
## beta = 0.29, 95% CI [-0.84, 1.43])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.94, 95% CI [-9.22, 17.10], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-14.36, 9.02], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.33, 95% CI [-1.78, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SO4_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to SO4_5yrPreCensor = 0, is at 46.10 (95% CI [40.44, 51.77],
## t(2068) = 15.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.04, 95% CI [-7.53, -2.55], t(2068) = -3.98, p < .001; Std. beta = -0.57, 95%
## CI [-0.74, -0.41])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.59, 95% CI [-3.05, -0.14], t(2068) = -2.14, p = 0.032; Std. beta =
## -0.13, 95% CI [-0.29, 0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-33.41, 20.49], t(2068) = -0.47, p = 0.638; Std. beta = -3.96,
## 95% CI [-7.37, -0.55])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.05, 95% CI [1.23, 40.87], t(2068) = 2.08, p = 0.037; Std. beta = 1.35, 95%
## CI [0.06, 2.65])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.81, 95% CI [-27.27, 9.65], t(2068) = -0.94, p = 0.349; Std. beta = -0.75,
## 95% CI [-2.20, 0.70])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -15.27, 95% CI [-30.70, 0.16], t(2068) = -1.94, p = 0.052; Std. beta = -1.38,
## 95% CI [-2.88, 0.11])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 2.13, 95% CI [-17.01, 21.27], t(2068) = 0.22, p = 0.827; Std. beta = 0.50,
## 95% CI [-0.87, 1.87])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.04, 95% CI [-5.95, 10.03], t(2068) = 0.50, p = 0.617; Std. beta = -0.10,
## 95% CI [-0.62, 0.42])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.26, 95% CI [-31.07, 6.56], t(2068) = -1.28, p = 0.202; Std. beta = -0.70,
## 95% CI [-1.99, 0.59])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.47, 95% CI [10.37, 22.58], t(2068) = 5.29, p < .001; Std. beta = 1.06, 95%
## CI [0.65, 1.47])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-6.58, 14.87], t(2068) = 0.76, p = 0.449; Std. beta = 0.17, 95%
## CI [-0.54, 0.88])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.58, 95% CI [-12.82, -0.34], t(2068) = -2.07, p = 0.039; Std. beta = -0.26,
## 95% CI [-0.69, 0.16])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.32, 95% CI [-25.50, -3.14], t(2068) = -2.51, p = 0.012; Std. beta = -0.68,
## 95% CI [-1.60, 0.23])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-8.50, 3.95], t(2068) = -0.72, p = 0.474; Std. beta = -0.14,
## 95% CI [-0.55, 0.28])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.87, 95% CI [-14.21, 0.47], t(2068) = -1.83, p = 0.067; Std. beta = -0.30,
## 95% CI [-0.79, 0.19])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-12.59, 25.81], t(2068) = 0.68, p = 0.500; Std. beta = -0.90,
## 95% CI [-2.54, 0.75])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-27.85, 2.95], t(2068) = -1.59, p = 0.113; Std. beta = -0.41,
## 95% CI [-1.42, 0.59])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-30.86, 21.87], t(2068) = -0.33, p = 0.738; Std. beta = -0.31,
## 95% CI [-2.10, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-15.08, 8.23], t(2068) = -0.58, p = 0.565; Std. beta = 0.31,
## 95% CI [-0.51, 1.12])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.79, 5.72], t(2068) = -1.36, p = 0.173; Std. beta = -0.71,
## 95% CI [-2.00, 0.58])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -13.14, 95% CI [-27.82, 1.53], t(2068) = -1.76, p = 0.079; Std. beta = -0.92,
## 95% CI [-1.90, 0.05])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-39.45, 19.68], t(2068) = -0.66, p = 0.512; Std. beta = -1.77,
## 95% CI [-5.19, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.73, 95% CI [-53.65, 0.20], t(2068) = -1.95, p = 0.052; Std. beta = -2.00,
## 95% CI [-4.63, 0.63])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -11.78, 95% CI [-23.82, 0.26], t(2068) = -1.92, p = 0.055; Std. beta = -0.89,
## 95% CI [-1.73, -0.06])
## - The effect of site [17R] is statistically significant and positive (beta =
## 56.34, 95% CI [29.43, 83.25], t(2068) = 4.11, p < .001; Std. beta = 3.83, 95%
## CI [2.00, 5.66])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.90, 95% CI [-27.06, 11.26], t(2068) = -0.81, p = 0.419; Std. beta = -1.62,
## 95% CI [-4.14, 0.91])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-22.68, 2.93], t(2068) = -1.51, p = 0.131; Std. beta = -0.38,
## 95% CI [-1.46, 0.70])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-17.57, 5.23], t(2068) = -1.06, p = 0.288; Std. beta = -0.30,
## 95% CI [-1.14, 0.54])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.68, 95% CI [-40.77, 9.41], t(2068) = -1.23, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.07, 1.10])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.22, 95% CI [-23.12, -5.31], t(2068) = -3.13, p = 0.002; Std. beta = -0.49,
## 95% CI [-1.16, 0.18])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.58, 95% CI [-33.93, -9.23], t(2068) = -3.43, p < .001; Std. beta = -1.55,
## 95% CI [-2.72, -0.37])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std. beta = -0.43,
## 95% CI [-1.15, 0.29])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-22.00, 1.38], t(2068) = -1.73, p = 0.084; Std. beta = -0.88,
## 95% CI [-1.68, -0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.71, 95% CI [-35.43, -4.00], t(2068) = -2.46, p = 0.014; Std. beta = -2.29,
## 95% CI [-4.86, 0.28])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-29.54, 23.16], t(2068) = -0.24, p = 0.812; Std. beta = -0.49,
## 95% CI [-2.11, 1.13])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-15.19, 8.51], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.82, 0.68])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-12.87, 14.67], t(2068) = 0.13, p = 0.898; Std. beta = -0.03,
## 95% CI [-0.99, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.16, 95% CI [-24.40, 2.07], t(2068) = -1.65, p = 0.098; Std. beta = -1.08,
## 95% CI [-2.08, -0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-18.49, 2.24], t(2068) = -1.54, p = 0.124; Std. beta = -0.44,
## 95% CI [-1.15, 0.26])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.39, 95% CI [-33.27, -1.52], t(2068) = -2.15, p = 0.032; Std. beta = -0.28,
## 95% CI [-1.41, 0.84])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-11.55, 12.59], t(2068) = 0.09, p = 0.932; Std. beta = 0.58,
## 95% CI [-0.27, 1.43])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.66, 11.70], t(2068) = -0.22, p = 0.825; Std. beta = -0.23,
## 95% CI [-1.10, 0.64])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-14.16, 4.42], t(2068) = -1.03, p = 0.304; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.44, 28.39], t(2068) = 0.15, p = 0.883; Std. beta = -2.93,
## 95% CI [-5.10, -0.76])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-20.89, 16.34], t(2068) = -0.24, p = 0.811; Std. beta = 0.09,
## 95% CI [-1.25, 1.42])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.99, 95% CI [-32.53, -1.44], t(2068) = -2.14, p = 0.032; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.58, 95% CI [-20.59, -2.58], t(2068) = -2.52, p = 0.012; Std. beta = -1.06,
## 95% CI [-2.17, 0.04])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.21, 95% CI [-0.45, 0.88], t(2068) =
## 0.63, p = 0.530; Std. beta = 0.04, 95% CI [-0.09, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.22, 95% CI [-70.64, 2.19], t(2068) = -1.84, p = 0.065;
## Std. beta = -4.24, 95% CI [-8.75, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.58, 11.03], t(2068) = -0.13, p = 0.898;
## Std. beta = -0.10, 95% CI [-1.56, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-13.85, 10.90], t(2068) = -0.23, p = 0.815;
## Std. beta = -0.18, 95% CI [-1.72, 1.35])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.36, 95% CI [-18.22, 11.51], t(2068) = -0.44, p = 0.658;
## Std. beta = -0.42, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-6.55, 13.42], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.43, 95% CI [-0.81, 1.66])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-5.48, 0.81], t(2068) = -1.46, p = 0.145; Std.
## beta = -0.29, 95% CI [-0.68, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-7.15, 9.75], t(2068) = 0.30, p = 0.763; Std.
## beta = 0.16, 95% CI [-0.89, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-3.18, 1.99], t(2068) = -0.45, p = 0.652; Std.
## beta = -0.07, 95% CI [-0.39, 0.25])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-5.80, 3.64], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.13, 95% CI [-0.72, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.78, 95% CI [-0.95, 4.51], t(2068) = 1.28, p = 0.201; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.73, 10.43], t(2068) = 0.74, p = 0.461; Std.
## beta = 0.35, 95% CI [-0.59, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-2.49, 2.85], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.02, 95% CI [-0.31, 0.35])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-1.84, 5.08], t(2068) = 0.92, p = 0.359; Std.
## beta = 0.20, 95% CI [-0.23, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.08, 95% CI [-29.19, 3.02], t(2068) = -1.59, p = 0.111;
## Std. beta = -1.62, 95% CI [-3.62, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-2.72, 11.16], t(2068) = 1.19, p = 0.233; Std.
## beta = 0.52, 95% CI [-0.34, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.34, 10.88], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.65, 95% CI [-0.04, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-6.37, 9.80], t(2068) = 0.42, p = 0.678; Std.
## beta = 0.21, 95% CI [-0.79, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.15, 7.62], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.01, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.72, 95% CI [-57.20, 35.76], t(2068) = -0.45, p = 0.651;
## Std. beta = -1.33, 95% CI [-7.09, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-29.56, 26.06], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.22, 95% CI [-3.66, 3.23])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.29, 4.53], t(2068) = -0.32, p = 0.750; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.50, 95% CI [-35.99, 14.99], t(2068) = -0.81, p = 0.419;
## Std. beta = -1.30, 95% CI [-4.46, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.86, 12.49], t(2068) = 0.57, p = 0.568; Std.
## beta = 0.35, 95% CI [-0.85, 1.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-5.66, 8.00], t(2068) = 0.34, p = 0.736; Std.
## beta = 0.15, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.68, 95% CI [-3.78, 15.13], t(2068) = 1.18, p = 0.239; Std.
## beta = 0.70, 95% CI [-0.47, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.01, 10.24], t(2068) = 1.61, p = 0.108; Std.
## beta = 0.57, 95% CI [-0.12, 1.27])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-11.38, 9.87], t(2068) = -0.14, p = 0.889; Std.
## beta = -0.09, 95% CI [-1.41, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-8.31, 2.03], t(2068) = -1.19, p = 0.234; Std.
## beta = -0.39, 95% CI [-1.03, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.87, 4.38], t(2068) = -0.56, p = 0.576; Std.
## beta = -0.22, 95% CI [-0.97, 0.54])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.21, 95% CI [-34.87, 16.45], t(2068) = -0.70, p = 0.481;
## Std. beta = -1.14, 95% CI [-4.32, 2.04])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.79, 7.48], t(2068) = -0.51, p = 0.607; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.60, 5.70], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.19, 95% CI [-0.32, 0.71])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-8.06, 6.38], t(2068) = -0.23, p = 0.819; Std.
## beta = -0.10, 95% CI [-1.00, 0.79])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-10.65, 4.36], t(2068) = -0.82, p = 0.411; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-3.84, 5.99], t(2068) = 0.43, p = 0.667; Std.
## beta = 0.13, 95% CI [-0.48, 0.74])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.75, 95% CI [-0.46, 17.96], t(2068) = 1.86, p = 0.063; Std.
## beta = 1.08, 95% CI [-0.06, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-0.67, 11.27], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.66, 95% CI [-0.08, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.02, 4.59], t(2068) = -0.41, p = 0.682; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.77, 2.21], t(2068) = -0.88, p = 0.381; Std.
## beta = -0.22, 95% CI [-0.71, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.83, 95% CI [-50.40, -9.26], t(2068) = -2.84, p = 0.005;
## Std. beta = -3.69, 95% CI [-6.24, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-6.81, 11.53], t(2068) = 0.50, p = 0.614; Std.
## beta = 0.29, 95% CI [-0.84, 1.43])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.94, 95% CI [-9.22, 17.10], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-14.36, 9.02], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.33, 95% CI [-1.78, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.34. The model's intercept, corresponding to site =
## Simmons, is at 46.10 (95% CI [40.44, 51.77], t(2068) = 15.96, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.04, 95% CI [-7.53, -2.55], t(2068) = -3.98, p < .001; Std. beta = -0.57, 95%
## CI [-0.74, -0.41])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.59, 95% CI [-3.05, -0.14], t(2068) = -2.14, p = 0.032; Std. beta =
## -0.13, 95% CI [-0.29, 0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-33.41, 20.49], t(2068) = -0.47, p = 0.638; Std. beta = -3.96,
## 95% CI [-7.37, -0.55])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.05, 95% CI [1.23, 40.87], t(2068) = 2.08, p = 0.037; Std. beta = 1.35, 95%
## CI [0.06, 2.65])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.81, 95% CI [-27.27, 9.65], t(2068) = -0.94, p = 0.349; Std. beta = -0.75,
## 95% CI [-2.20, 0.70])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -15.27, 95% CI [-30.70, 0.16], t(2068) = -1.94, p = 0.052; Std. beta = -1.38,
## 95% CI [-2.88, 0.11])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 2.13, 95% CI [-17.01, 21.27], t(2068) = 0.22, p = 0.827; Std. beta = 0.50,
## 95% CI [-0.87, 1.87])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.04, 95% CI [-5.95, 10.03], t(2068) = 0.50, p = 0.617; Std. beta = -0.10,
## 95% CI [-0.62, 0.42])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.26, 95% CI [-31.07, 6.56], t(2068) = -1.28, p = 0.202; Std. beta = -0.70,
## 95% CI [-1.99, 0.59])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.47, 95% CI [10.37, 22.58], t(2068) = 5.29, p < .001; Std. beta = 1.06, 95%
## CI [0.65, 1.47])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-6.58, 14.87], t(2068) = 0.76, p = 0.449; Std. beta = 0.17, 95%
## CI [-0.54, 0.88])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.58, 95% CI [-12.82, -0.34], t(2068) = -2.07, p = 0.039; Std. beta = -0.26,
## 95% CI [-0.69, 0.16])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.32, 95% CI [-25.50, -3.14], t(2068) = -2.51, p = 0.012; Std. beta = -0.68,
## 95% CI [-1.60, 0.23])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-8.50, 3.95], t(2068) = -0.72, p = 0.474; Std. beta = -0.14,
## 95% CI [-0.55, 0.28])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.87, 95% CI [-14.21, 0.47], t(2068) = -1.83, p = 0.067; Std. beta = -0.30,
## 95% CI [-0.79, 0.19])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-12.59, 25.81], t(2068) = 0.68, p = 0.500; Std. beta = -0.90,
## 95% CI [-2.54, 0.75])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-27.85, 2.95], t(2068) = -1.59, p = 0.113; Std. beta = -0.41,
## 95% CI [-1.42, 0.59])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-30.86, 21.87], t(2068) = -0.33, p = 0.738; Std. beta = -0.31,
## 95% CI [-2.10, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-15.08, 8.23], t(2068) = -0.58, p = 0.565; Std. beta = 0.31,
## 95% CI [-0.51, 1.12])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.79, 5.72], t(2068) = -1.36, p = 0.173; Std. beta = -0.71,
## 95% CI [-2.00, 0.58])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -13.14, 95% CI [-27.82, 1.53], t(2068) = -1.76, p = 0.079; Std. beta = -0.92,
## 95% CI [-1.90, 0.05])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-39.45, 19.68], t(2068) = -0.66, p = 0.512; Std. beta = -1.77,
## 95% CI [-5.19, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.73, 95% CI [-53.65, 0.20], t(2068) = -1.95, p = 0.052; Std. beta = -2.00,
## 95% CI [-4.63, 0.63])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -11.78, 95% CI [-23.82, 0.26], t(2068) = -1.92, p = 0.055; Std. beta = -0.89,
## 95% CI [-1.73, -0.06])
## - The effect of site [17R] is statistically significant and positive (beta =
## 56.34, 95% CI [29.43, 83.25], t(2068) = 4.11, p < .001; Std. beta = 3.83, 95%
## CI [2.00, 5.66])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.90, 95% CI [-27.06, 11.26], t(2068) = -0.81, p = 0.419; Std. beta = -1.62,
## 95% CI [-4.14, 0.91])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-22.68, 2.93], t(2068) = -1.51, p = 0.131; Std. beta = -0.38,
## 95% CI [-1.46, 0.70])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-17.57, 5.23], t(2068) = -1.06, p = 0.288; Std. beta = -0.30,
## 95% CI [-1.14, 0.54])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.68, 95% CI [-40.77, 9.41], t(2068) = -1.23, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.07, 1.10])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.22, 95% CI [-23.12, -5.31], t(2068) = -3.13, p = 0.002; Std. beta = -0.49,
## 95% CI [-1.16, 0.18])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.58, 95% CI [-33.93, -9.23], t(2068) = -3.43, p < .001; Std. beta = -1.55,
## 95% CI [-2.72, -0.37])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std. beta = -0.43,
## 95% CI [-1.15, 0.29])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-22.00, 1.38], t(2068) = -1.73, p = 0.084; Std. beta = -0.88,
## 95% CI [-1.68, -0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.71, 95% CI [-35.43, -4.00], t(2068) = -2.46, p = 0.014; Std. beta = -2.29,
## 95% CI [-4.86, 0.28])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-29.54, 23.16], t(2068) = -0.24, p = 0.812; Std. beta = -0.49,
## 95% CI [-2.11, 1.13])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-15.19, 8.51], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.82, 0.68])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-12.87, 14.67], t(2068) = 0.13, p = 0.898; Std. beta = -0.03,
## 95% CI [-0.99, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.16, 95% CI [-24.40, 2.07], t(2068) = -1.65, p = 0.098; Std. beta = -1.08,
## 95% CI [-2.08, -0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-18.49, 2.24], t(2068) = -1.54, p = 0.124; Std. beta = -0.44,
## 95% CI [-1.15, 0.26])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.39, 95% CI [-33.27, -1.52], t(2068) = -2.15, p = 0.032; Std. beta = -0.28,
## 95% CI [-1.41, 0.84])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-11.55, 12.59], t(2068) = 0.09, p = 0.932; Std. beta = 0.58,
## 95% CI [-0.27, 1.43])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.66, 11.70], t(2068) = -0.22, p = 0.825; Std. beta = -0.23,
## 95% CI [-1.10, 0.64])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-14.16, 4.42], t(2068) = -1.03, p = 0.304; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.44, 28.39], t(2068) = 0.15, p = 0.883; Std. beta = -2.93,
## 95% CI [-5.10, -0.76])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-20.89, 16.34], t(2068) = -0.24, p = 0.811; Std. beta = 0.09,
## 95% CI [-1.25, 1.42])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.99, 95% CI [-32.53, -1.44], t(2068) = -2.14, p = 0.032; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.58, 95% CI [-20.59, -2.58], t(2068) = -2.52, p = 0.012; Std. beta = -1.06,
## 95% CI [-2.17, 0.04])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.21, 95% CI [-0.45, 0.88], t(2068) =
## 0.63, p = 0.530; Std. beta = 0.04, 95% CI [-0.09, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.22, 95% CI [-70.64, 2.19], t(2068) = -1.84, p = 0.065;
## Std. beta = -4.24, 95% CI [-8.75, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.58, 11.03], t(2068) = -0.13, p = 0.898;
## Std. beta = -0.10, 95% CI [-1.56, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-13.85, 10.90], t(2068) = -0.23, p = 0.815;
## Std. beta = -0.18, 95% CI [-1.72, 1.35])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.36, 95% CI [-18.22, 11.51], t(2068) = -0.44, p = 0.658;
## Std. beta = -0.42, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-6.55, 13.42], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.43, 95% CI [-0.81, 1.66])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-5.48, 0.81], t(2068) = -1.46, p = 0.145; Std.
## beta = -0.29, 95% CI [-0.68, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-7.15, 9.75], t(2068) = 0.30, p = 0.763; Std.
## beta = 0.16, 95% CI [-0.89, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-3.18, 1.99], t(2068) = -0.45, p = 0.652; Std.
## beta = -0.07, 95% CI [-0.39, 0.25])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-5.80, 3.64], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.13, 95% CI [-0.72, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.78, 95% CI [-0.95, 4.51], t(2068) = 1.28, p = 0.201; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.73, 10.43], t(2068) = 0.74, p = 0.461; Std.
## beta = 0.35, 95% CI [-0.59, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-2.49, 2.85], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.02, 95% CI [-0.31, 0.35])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-1.84, 5.08], t(2068) = 0.92, p = 0.359; Std.
## beta = 0.20, 95% CI [-0.23, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.08, 95% CI [-29.19, 3.02], t(2068) = -1.59, p = 0.111;
## Std. beta = -1.62, 95% CI [-3.62, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-2.72, 11.16], t(2068) = 1.19, p = 0.233; Std.
## beta = 0.52, 95% CI [-0.34, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.34, 10.88], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.65, 95% CI [-0.04, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-6.37, 9.80], t(2068) = 0.42, p = 0.678; Std.
## beta = 0.21, 95% CI [-0.79, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.15, 7.62], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.01, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.72, 95% CI [-57.20, 35.76], t(2068) = -0.45, p = 0.651;
## Std. beta = -1.33, 95% CI [-7.09, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-29.56, 26.06], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.22, 95% CI [-3.66, 3.23])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.29, 4.53], t(2068) = -0.32, p = 0.750; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.50, 95% CI [-35.99, 14.99], t(2068) = -0.81, p = 0.419;
## Std. beta = -1.30, 95% CI [-4.46, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.86, 12.49], t(2068) = 0.57, p = 0.568; Std.
## beta = 0.35, 95% CI [-0.85, 1.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-5.66, 8.00], t(2068) = 0.34, p = 0.736; Std.
## beta = 0.15, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.68, 95% CI [-3.78, 15.13], t(2068) = 1.18, p = 0.239; Std.
## beta = 0.70, 95% CI [-0.47, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.01, 10.24], t(2068) = 1.61, p = 0.108; Std.
## beta = 0.57, 95% CI [-0.12, 1.27])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-11.38, 9.87], t(2068) = -0.14, p = 0.889; Std.
## beta = -0.09, 95% CI [-1.41, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-8.31, 2.03], t(2068) = -1.19, p = 0.234; Std.
## beta = -0.39, 95% CI [-1.03, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.87, 4.38], t(2068) = -0.56, p = 0.576; Std.
## beta = -0.22, 95% CI [-0.97, 0.54])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.21, 95% CI [-34.87, 16.45], t(2068) = -0.70, p = 0.481;
## Std. beta = -1.14, 95% CI [-4.32, 2.04])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.79, 7.48], t(2068) = -0.51, p = 0.607; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.60, 5.70], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.19, 95% CI [-0.32, 0.71])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-8.06, 6.38], t(2068) = -0.23, p = 0.819; Std.
## beta = -0.10, 95% CI [-1.00, 0.79])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-10.65, 4.36], t(2068) = -0.82, p = 0.411; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-3.84, 5.99], t(2068) = 0.43, p = 0.667; Std.
## beta = 0.13, 95% CI [-0.48, 0.74])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.75, 95% CI [-0.46, 17.96], t(2068) = 1.86, p = 0.063; Std.
## beta = 1.08, 95% CI [-0.06, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-0.67, 11.27], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.66, 95% CI [-0.08, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.02, 4.59], t(2068) = -0.41, p = 0.682; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.77, 2.21], t(2068) = -0.88, p = 0.381; Std.
## beta = -0.22, 95% CI [-0.71, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.83, 95% CI [-50.40, -9.26], t(2068) = -2.84, p = 0.005;
## Std. beta = -3.69, 95% CI [-6.24, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-6.81, 11.53], t(2068) = 0.50, p = 0.614; Std.
## beta = 0.29, 95% CI [-0.84, 1.43])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.94, 95% CI [-9.22, 17.10], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-14.36, 9.02], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.33, 95% CI [-1.78, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to cohort = CARE-PF, is at 46.10 (95% CI [40.44, 51.77], t(2068)
## = 15.96, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.04, 95% CI [-7.53, -2.55], t(2068) = -3.98, p < .001; Std. beta = -0.57, 95%
## CI [-0.74, -0.41])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.59, 95% CI [-3.05, -0.14], t(2068) = -2.14, p = 0.032; Std. beta =
## -0.13, 95% CI [-0.29, 0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -6.46, 95% CI [-33.41, 20.49], t(2068) = -0.47, p = 0.638; Std. beta = -3.96,
## 95% CI [-7.37, -0.55])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.05, 95% CI [1.23, 40.87], t(2068) = 2.08, p = 0.037; Std. beta = 1.35, 95%
## CI [0.06, 2.65])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.81, 95% CI [-27.27, 9.65], t(2068) = -0.94, p = 0.349; Std. beta = -0.75,
## 95% CI [-2.20, 0.70])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -15.27, 95% CI [-30.70, 0.16], t(2068) = -1.94, p = 0.052; Std. beta = -1.38,
## 95% CI [-2.88, 0.11])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 2.13, 95% CI [-17.01, 21.27], t(2068) = 0.22, p = 0.827; Std. beta = 0.50,
## 95% CI [-0.87, 1.87])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.04, 95% CI [-5.95, 10.03], t(2068) = 0.50, p = 0.617; Std. beta = -0.10,
## 95% CI [-0.62, 0.42])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.26, 95% CI [-31.07, 6.56], t(2068) = -1.28, p = 0.202; Std. beta = -0.70,
## 95% CI [-1.99, 0.59])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.47, 95% CI [10.37, 22.58], t(2068) = 5.29, p < .001; Std. beta = 1.06, 95%
## CI [0.65, 1.47])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.14, 95% CI [-6.58, 14.87], t(2068) = 0.76, p = 0.449; Std. beta = 0.17, 95%
## CI [-0.54, 0.88])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.58, 95% CI [-12.82, -0.34], t(2068) = -2.07, p = 0.039; Std. beta = -0.26,
## 95% CI [-0.69, 0.16])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.32, 95% CI [-25.50, -3.14], t(2068) = -2.51, p = 0.012; Std. beta = -0.68,
## 95% CI [-1.60, 0.23])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-8.50, 3.95], t(2068) = -0.72, p = 0.474; Std. beta = -0.14,
## 95% CI [-0.55, 0.28])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.87, 95% CI [-14.21, 0.47], t(2068) = -1.83, p = 0.067; Std. beta = -0.30,
## 95% CI [-0.79, 0.19])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.61, 95% CI [-12.59, 25.81], t(2068) = 0.68, p = 0.500; Std. beta = -0.90,
## 95% CI [-2.54, 0.75])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.45, 95% CI [-27.85, 2.95], t(2068) = -1.59, p = 0.113; Std. beta = -0.41,
## 95% CI [-1.42, 0.59])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.49, 95% CI [-30.86, 21.87], t(2068) = -0.33, p = 0.738; Std. beta = -0.31,
## 95% CI [-2.10, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-15.08, 8.23], t(2068) = -0.58, p = 0.565; Std. beta = 0.31,
## 95% CI [-0.51, 1.12])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.79, 5.72], t(2068) = -1.36, p = 0.173; Std. beta = -0.71,
## 95% CI [-2.00, 0.58])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -13.14, 95% CI [-27.82, 1.53], t(2068) = -1.76, p = 0.079; Std. beta = -0.92,
## 95% CI [-1.90, 0.05])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-39.45, 19.68], t(2068) = -0.66, p = 0.512; Std. beta = -1.77,
## 95% CI [-5.19, 1.65])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.73, 95% CI [-53.65, 0.20], t(2068) = -1.95, p = 0.052; Std. beta = -2.00,
## 95% CI [-4.63, 0.63])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -11.78, 95% CI [-23.82, 0.26], t(2068) = -1.92, p = 0.055; Std. beta = -0.89,
## 95% CI [-1.73, -0.06])
## - The effect of site [17R] is statistically significant and positive (beta =
## 56.34, 95% CI [29.43, 83.25], t(2068) = 4.11, p < .001; Std. beta = 3.83, 95%
## CI [2.00, 5.66])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -7.90, 95% CI [-27.06, 11.26], t(2068) = -0.81, p = 0.419; Std. beta = -1.62,
## 95% CI [-4.14, 0.91])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.88, 95% CI [-22.68, 2.93], t(2068) = -1.51, p = 0.131; Std. beta = -0.38,
## 95% CI [-1.46, 0.70])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -6.17, 95% CI [-17.57, 5.23], t(2068) = -1.06, p = 0.288; Std. beta = -0.30,
## 95% CI [-1.14, 0.54])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.68, 95% CI [-40.77, 9.41], t(2068) = -1.23, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.07, 1.10])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.22, 95% CI [-23.12, -5.31], t(2068) = -3.13, p = 0.002; Std. beta = -0.49,
## 95% CI [-1.16, 0.18])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.58, 95% CI [-33.93, -9.23], t(2068) = -3.43, p < .001; Std. beta = -1.55,
## 95% CI [-2.72, -0.37])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std. beta = -0.43,
## 95% CI [-1.15, 0.29])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.31, 95% CI [-22.00, 1.38], t(2068) = -1.73, p = 0.084; Std. beta = -0.88,
## 95% CI [-1.68, -0.08])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.71, 95% CI [-35.43, -4.00], t(2068) = -2.46, p = 0.014; Std. beta = -2.29,
## 95% CI [-4.86, 0.28])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.19, 95% CI [-29.54, 23.16], t(2068) = -0.24, p = 0.812; Std. beta = -0.49,
## 95% CI [-2.11, 1.13])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-15.19, 8.51], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.82, 0.68])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-12.87, 14.67], t(2068) = 0.13, p = 0.898; Std. beta = -0.03,
## 95% CI [-0.99, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.16, 95% CI [-24.40, 2.07], t(2068) = -1.65, p = 0.098; Std. beta = -1.08,
## 95% CI [-2.08, -0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-18.49, 2.24], t(2068) = -1.54, p = 0.124; Std. beta = -0.44,
## 95% CI [-1.15, 0.26])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.39, 95% CI [-33.27, -1.52], t(2068) = -2.15, p = 0.032; Std. beta = -0.28,
## 95% CI [-1.41, 0.84])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 0.52, 95% CI [-11.55, 12.59], t(2068) = 0.09, p = 0.932; Std. beta = 0.58,
## 95% CI [-0.27, 1.43])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.66, 11.70], t(2068) = -0.22, p = 0.825; Std. beta = -0.23,
## 95% CI [-1.10, 0.64])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.87, 95% CI [-14.16, 4.42], t(2068) = -1.03, p = 0.304; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 1.98, 95% CI [-24.44, 28.39], t(2068) = 0.15, p = 0.883; Std. beta = -2.93,
## 95% CI [-5.10, -0.76])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -2.27, 95% CI [-20.89, 16.34], t(2068) = -0.24, p = 0.811; Std. beta = 0.09,
## 95% CI [-1.25, 1.42])
## - The effect of site [41R] is statistically significant and negative (beta =
## -16.99, 95% CI [-32.53, -1.44], t(2068) = -2.14, p = 0.032; Std. beta = -0.75,
## 95% CI [-2.13, 0.63])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.58, 95% CI [-20.59, -2.58], t(2068) = -2.52, p = 0.012; Std. beta = -1.06,
## 95% CI [-2.17, 0.04])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.21, 95% CI [-0.45, 0.88], t(2068) =
## 0.63, p = 0.530; Std. beta = 0.04, 95% CI [-0.09, 0.17])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.22, 95% CI [-70.64, 2.19], t(2068) = -1.84, p = 0.065;
## Std. beta = -4.24, 95% CI [-8.75, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-12.58, 11.03], t(2068) = -0.13, p = 0.898;
## Std. beta = -0.10, 95% CI [-1.56, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-13.85, 10.90], t(2068) = -0.23, p = 0.815;
## Std. beta = -0.18, 95% CI [-1.72, 1.35])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.36, 95% CI [-18.22, 11.51], t(2068) = -0.44, p = 0.658;
## Std. beta = -0.42, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.44, 95% CI [-6.55, 13.42], t(2068) = 0.67, p = 0.500; Std.
## beta = 0.43, 95% CI [-0.81, 1.66])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-5.48, 0.81], t(2068) = -1.46, p = 0.145; Std.
## beta = -0.29, 95% CI [-0.68, 0.10])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-7.15, 9.75], t(2068) = 0.30, p = 0.763; Std.
## beta = 0.16, 95% CI [-0.89, 1.21])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.59, 95% CI [-3.18, 1.99], t(2068) = -0.45, p = 0.652; Std.
## beta = -0.07, 95% CI [-0.39, 0.25])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-5.80, 3.64], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.13, 95% CI [-0.72, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.78, 95% CI [-0.95, 4.51], t(2068) = 1.28, p = 0.201; Std.
## beta = 0.22, 95% CI [-0.12, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.85, 95% CI [-4.73, 10.43], t(2068) = 0.74, p = 0.461; Std.
## beta = 0.35, 95% CI [-0.59, 1.29])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.18, 95% CI [-2.49, 2.85], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.02, 95% CI [-0.31, 0.35])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.62, 95% CI [-1.84, 5.08], t(2068) = 0.92, p = 0.359; Std.
## beta = 0.20, 95% CI [-0.23, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.08, 95% CI [-29.19, 3.02], t(2068) = -1.59, p = 0.111;
## Std. beta = -1.62, 95% CI [-3.62, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.22, 95% CI [-2.72, 11.16], t(2068) = 1.19, p = 0.233; Std.
## beta = 0.52, 95% CI [-0.34, 1.38])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.27, 95% CI [-0.34, 10.88], t(2068) = 1.84, p = 0.066; Std.
## beta = 0.65, 95% CI [-0.04, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-6.37, 9.80], t(2068) = 0.42, p = 0.678; Std.
## beta = 0.21, 95% CI [-0.79, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.15, 7.62], t(2068) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.01, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.72, 95% CI [-57.20, 35.76], t(2068) = -0.45, p = 0.651;
## Std. beta = -1.33, 95% CI [-7.09, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-29.56, 26.06], t(2068) = -0.12, p = 0.902;
## Std. beta = -0.22, 95% CI [-3.66, 3.23])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.88, 95% CI [-6.29, 4.53], t(2068) = -0.32, p = 0.750; Std.
## beta = -0.11, 95% CI [-0.78, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.50, 95% CI [-35.99, 14.99], t(2068) = -0.81, p = 0.419;
## Std. beta = -1.30, 95% CI [-4.46, 1.86])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.86, 12.49], t(2068) = 0.57, p = 0.568; Std.
## beta = 0.35, 95% CI [-0.85, 1.55])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-5.66, 8.00], t(2068) = 0.34, p = 0.736; Std.
## beta = 0.15, 95% CI [-0.70, 0.99])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.68, 95% CI [-3.78, 15.13], t(2068) = 1.18, p = 0.239; Std.
## beta = 0.70, 95% CI [-0.47, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.62, 95% CI [-1.01, 10.24], t(2068) = 1.61, p = 0.108; Std.
## beta = 0.57, 95% CI [-0.12, 1.27])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-11.38, 9.87], t(2068) = -0.14, p = 0.889; Std.
## beta = -0.09, 95% CI [-1.41, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.14, 95% CI [-8.31, 2.03], t(2068) = -1.19, p = 0.234; Std.
## beta = -0.39, 95% CI [-1.03, 0.25])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-7.87, 4.38], t(2068) = -0.56, p = 0.576; Std.
## beta = -0.22, 95% CI [-0.97, 0.54])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.21, 95% CI [-34.87, 16.45], t(2068) = -0.70, p = 0.481;
## Std. beta = -1.14, 95% CI [-4.32, 2.04])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.66, 95% CI [-12.79, 7.48], t(2068) = -0.51, p = 0.607; Std.
## beta = -0.33, 95% CI [-1.58, 0.93])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-2.60, 5.70], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.19, 95% CI [-0.32, 0.71])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-8.06, 6.38], t(2068) = -0.23, p = 0.819; Std.
## beta = -0.10, 95% CI [-1.00, 0.79])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.15, 95% CI [-10.65, 4.36], t(2068) = -0.82, p = 0.411; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.08, 95% CI [-3.84, 5.99], t(2068) = 0.43, p = 0.667; Std.
## beta = 0.13, 95% CI [-0.48, 0.74])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.75, 95% CI [-0.46, 17.96], t(2068) = 1.86, p = 0.063; Std.
## beta = 1.08, 95% CI [-0.06, 2.23])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.30, 95% CI [-0.67, 11.27], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.66, 95% CI [-0.08, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.02, 4.59], t(2068) = -0.41, p = 0.682; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.77, 2.21], t(2068) = -0.88, p = 0.381; Std.
## beta = -0.22, 95% CI [-0.71, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.83, 95% CI [-50.40, -9.26], t(2068) = -2.84, p = 0.005;
## Std. beta = -3.69, 95% CI [-6.24, -1.15])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-6.81, 11.53], t(2068) = 0.50, p = 0.614; Std.
## beta = 0.29, 95% CI [-0.84, 1.43])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.94, 95% CI [-9.22, 17.10], t(2068) = 0.59, p = 0.557; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-14.36, 9.02], t(2068) = -0.45, p = 0.654; Std.
## beta = -0.33, 95% CI [-1.78, 1.12])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*SO4_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14890.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1099 -0.4920 -0.0077 0.4425 7.1004
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 136.91 11.701
## time_firstPFT 11.19 3.346 -0.29
## Residual 41.85 6.469
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 44.48395 5.53950 8.030
## time_firstPFT -3.35633 2.53125 -1.326
## SO4_5yrPreCensor -1.88115 0.76043 -2.474
## disadv -6.18152 2.34179 -2.640
## dich_RaceNon-White -2.67166 2.27416 -1.175
## sexF -2.50550 1.40715 -1.781
## age_dx 0.14243 0.07367 1.933
## smokeHxFormer -2.81594 1.40300 -2.007
## smokeHxAlways 9.63607 7.02014 1.373
## smokeHxUnknown -1.43624 3.22247 -0.446
## site02R -11.34762 13.60783 -0.834
## site03R 15.75010 10.08668 1.561
## site04R -8.87002 9.25992 -0.958
## site05R -16.02889 7.77722 -2.061
## site06R -10.91951 13.48290 -0.810
## site07R -0.45035 4.04756 -0.111
## site09R -15.47267 9.50281 -1.628
## site101 15.92660 3.09981 5.138
## site102 1.94635 5.47741 0.355
## site103 -7.32883 3.24621 -2.258
## site104 -14.09020 5.65275 -2.493
## site105 -2.40309 3.15104 -0.763
## site106 -9.56656 3.77201 -2.536
## site107 3.23644 9.68421 0.334
## site108 -8.22262 8.09558 -1.016
## site10R -4.37705 13.42916 -0.326
## site11R -4.99639 5.86224 -0.852
## site12R -12.31209 9.41423 -1.308
## site13R -15.52950 7.42256 -2.092
## site14R -12.75758 15.01575 -0.850
## site15R -23.63769 13.56511 -1.743
## site16R -12.27245 6.15291 -1.995
## site17R 60.08422 13.64274 4.404
## site18R -6.70326 9.64677 -0.695
## site19R -11.99505 6.49070 -1.848
## site20R -7.15854 5.74977 -1.245
## site21R -15.85770 12.56586 -1.262
## site22R -17.53735 4.56523 -3.842
## site23R -28.69340 7.79067 -3.683
## site24R -2.92788 5.33920 -0.548
## site25R -13.84466 5.97425 -2.317
## site28R -18.59841 7.94128 -2.342
## site29R -7.90811 13.29620 -0.595
## site31R -4.92999 6.04974 -0.815
## site32R 0.22057 6.96647 0.032
## site33R -12.19886 6.67387 -1.828
## site34R -8.76251 5.21120 -1.681
## site35R -18.92463 8.01809 -2.360
## site36R -0.43454 6.08484 -0.071
## site37R -3.93172 6.71204 -0.586
## site38R -4.89674 4.66847 -1.049
## site39R 8.86958 13.50901 0.657
## site40R -4.37851 9.35613 -0.468
## site41R -18.64433 7.89274 -2.362
## site42R -14.16145 4.59016 -3.085
## time_firstPFT:SO4_5yrPreCensor 0.15365 0.35619 0.431
## time_firstPFT:disadv 1.56443 1.12198 1.394
## time_firstPFT:dich_RaceNon-White -0.54377 1.11200 -0.489
## time_firstPFT:sexF 0.73425 0.65712 1.117
## time_firstPFT:age_dx -0.03953 0.03442 -1.148
## time_firstPFT:smokeHxFormer -0.64465 0.67541 -0.954
## time_firstPFT:smokeHxAlways -6.40390 6.04203 -1.060
## time_firstPFT:smokeHxUnknown 2.17314 1.70050 1.278
## time_firstPFT:site02R -32.56440 18.59185 -1.752
## time_firstPFT:site03R -0.42386 6.07205 -0.070
## time_firstPFT:site04R -2.22341 6.34127 -0.351
## time_firstPFT:site05R -3.26257 7.59725 -0.429
## time_firstPFT:site07R -1.77576 1.64891 -1.077
## time_firstPFT:site09R 2.38226 4.33189 0.550
## time_firstPFT:site101 -0.49209 1.33071 -0.370
## time_firstPFT:site102 -0.49826 2.44674 -0.204
## time_firstPFT:site103 1.96829 1.45320 1.354
## time_firstPFT:site104 2.26609 3.91116 0.579
## time_firstPFT:site105 0.20581 1.37328 0.150
## time_firstPFT:site106 2.14116 1.81403 1.180
## time_firstPFT:site107 -12.23265 8.22701 -1.487
## time_firstPFT:site108 4.74780 3.72220 1.276
## time_firstPFT:site11R 5.91538 2.91127 2.032
## time_firstPFT:site12R 2.12504 4.13331 0.514
## time_firstPFT:site13R -0.20204 4.05672 -0.050
## time_firstPFT:site14R -9.50645 23.72157 -0.401
## time_firstPFT:site15R -2.15582 14.19406 -0.152
## time_firstPFT:site16R -1.04616 2.81522 -0.372
## time_firstPFT:site18R -10.44543 13.00877 -0.803
## time_firstPFT:site19R 2.74032 5.00713 0.547
## time_firstPFT:site20R 0.95960 3.53658 0.271
## time_firstPFT:site21R 6.22264 4.81091 1.293
## time_firstPFT:site22R 5.84380 2.92482 1.998
## time_firstPFT:site23R 23.08686 26.71919 0.864
## time_firstPFT:site24R -2.83887 2.64234 -1.074
## time_firstPFT:site25R -0.81701 3.19396 -0.256
## time_firstPFT:site28R -8.42195 13.15848 -0.640
## time_firstPFT:site29R -1.01263 5.21011 -0.194
## time_firstPFT:site31R 2.28460 2.18121 1.047
## time_firstPFT:site32R -0.40398 3.71404 -0.109
## time_firstPFT:site33R -3.63696 3.87685 -0.938
## time_firstPFT:site34R 1.15018 2.52073 0.456
## time_firstPFT:site35R 9.56419 4.73400 2.020
## time_firstPFT:site36R 5.34510 3.05986 1.747
## time_firstPFT:site37R -0.85584 3.07832 -0.278
## time_firstPFT:site38R -1.76091 2.04021 -0.863
## time_firstPFT:site39R -30.13397 10.56257 -2.853
## time_firstPFT:site40R 1.89879 4.72354 0.402
## time_firstPFT:site41R 4.77037 6.73360 0.708
## time_firstPFT:site42R -3.00820 5.97975 -0.503##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.799
## Unadjusted ICC: 0.525report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SO4_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 44.48 (95% CI [33.62, 55.35], t(2038)
## = 8.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SO4_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to
## SO4_5yrPreCensor = 0, is at 44.48 (95% CI [33.62, 55.35], t(2038) = 8.03, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to disadv = 0,
## is at 44.48 (95% CI [33.62, 55.35], t(2038) = 8.03, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to dich_Race =
## White, is at 44.48 (95% CI [33.62, 55.35], t(2038) = 8.03, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 44.48 (95% CI [33.62,
## 55.35], t(2038) = 8.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to age_dx = 0,
## is at 44.48 (95% CI [33.62, 55.35], t(2038) = 8.03, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to smokeHx =
## Never, is at 44.48 (95% CI [33.62, 55.35], t(2038) = 8.03, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 44.48 (95% CI [33.62,
## 55.35], t(2038) = 8.03, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SO4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 44.48 (95% CI [33.62, 55.35], t(2038) = 8.03, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.36, 95% CI [-8.32, 1.61], t(2038) = -1.33, p = 0.185; Std. beta =
## -0.58, 95% CI [-0.80, -0.35])
## - The effect of SO4 5yrPreCensor is statistically significant and negative
## (beta = -1.88, 95% CI [-3.37, -0.39], t(2038) = -2.47, p = 0.013; Std. beta =
## -0.17, 95% CI [-0.33, -0.01])
## - The effect of disadv is statistically significant and negative (beta = -6.18,
## 95% CI [-10.77, -1.59], t(2038) = -2.64, p = 0.008; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.13, 1.79], t(2038) = -1.17, p = 0.240; Std.
## beta = -0.24, 95% CI [-0.55, 0.08])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.51, 95% CI [-5.27, 0.25], t(2038) = -1.78, p = 0.075; Std. beta = -0.09, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-2.05e-03, 0.29], t(2038) = 1.93, p = 0.053; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.82, 95% CI [-5.57, -0.06], t(2038) = -2.01, p = 0.045; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.64, 95% CI [-4.13, 23.40], t(2038) = 1.37, p = 0.170; Std. beta =
## -5.68e-03, 95% CI [-1.26, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.44, 95% CI [-7.76, 4.88], t(2038) = -0.45, p = 0.656; Std. beta =
## 0.13, 95% CI [-0.34, 0.59])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -11.35, 95% CI [-38.03, 15.34], t(2038) = -0.83, p = 0.404; Std. beta =
## -4.13, 95% CI [-7.55, -0.71])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 15.75, 95% CI [-4.03, 35.53], t(2038) = 1.56, p = 0.119; Std. beta = 1.03,
## 95% CI [-0.28, 2.33])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -8.87, 95% CI [-27.03, 9.29], t(2038) = -0.96, p = 0.338; Std. beta = -0.83,
## 95% CI [-2.29, 0.62])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.03, 95% CI [-31.28, -0.78], t(2038) = -2.06, p = 0.039; Std. beta = -1.43,
## 95% CI [-2.93, 0.08])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -10.92, 95% CI [-37.36, 15.52], t(2038) = -0.81, p = 0.418; Std. beta =
## -0.74, 95% CI [-2.54, 1.05])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.45, 95% CI [-8.39, 7.49], t(2038) = -0.11, p = 0.911; Std. beta = -0.21,
## 95% CI [-0.74, 0.31])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -15.47, 95% CI [-34.11, 3.16], t(2038) = -1.63, p = 0.104; Std. beta = -0.81,
## 95% CI [-2.10, 0.49])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.93, 95% CI [9.85, 22.01], t(2038) = 5.14, p < .001; Std. beta = 1.03, 95% CI
## [0.62, 1.45])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.95, 95% CI [-8.80, 12.69], t(2038) = 0.36, p = 0.722; Std. beta = 0.08, 95%
## CI [-0.64, 0.80])
## - The effect of site [103] is statistically significant and negative (beta =
## -7.33, 95% CI [-13.70, -0.96], t(2038) = -2.26, p = 0.024; Std. beta = -0.29,
## 95% CI [-0.73, 0.14])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.09, 95% CI [-25.18, -3.00], t(2038) = -2.49, p = 0.013; Std. beta = -0.72,
## 95% CI [-1.65, 0.20])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-8.58, 3.78], t(2038) = -0.76, p = 0.446; Std. beta = -0.14,
## 95% CI [-0.56, 0.28])
## - The effect of site [106] is statistically significant and negative (beta =
## -9.57, 95% CI [-16.96, -2.17], t(2038) = -2.54, p = 0.011; Std. beta = -0.43,
## 95% CI [-0.93, 0.07])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 3.24, 95% CI [-15.76, 22.23], t(2038) = 0.33, p = 0.738; Std. beta = -1.04,
## 95% CI [-2.69, 0.61])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.22, 95% CI [-24.10, 7.65], t(2038) = -1.02, p = 0.310; Std. beta = -0.07,
## 95% CI [-1.12, 0.99])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.71, 21.96], t(2038) = -0.33, p = 0.745; Std. beta = -0.30,
## 95% CI [-2.09, 1.49])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-16.49, 6.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.27,
## 95% CI [-0.55, 1.09])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-30.77, 6.15], t(2038) = -1.31, p = 0.191; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically significant and negative (beta =
## -15.53, 95% CI [-30.09, -0.97], t(2038) = -2.09, p = 0.037; Std. beta = -1.08,
## 95% CI [-2.06, -0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -12.76, 95% CI [-42.21, 16.69], t(2038) = -0.85, p = 0.396; Std. beta =
## -1.85, 95% CI [-5.29, 1.59])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -23.64, 95% CI [-50.24, 2.97], t(2038) = -1.74, p = 0.082; Std. beta = -1.83,
## 95% CI [-4.47, 0.81])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.27, 95% CI [-24.34, -0.21], t(2038) = -1.99, p = 0.046; Std. beta = -0.94,
## 95% CI [-1.79, -0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.08, 95% CI [33.33, 86.84], t(2038) = 4.40, p < .001; Std. beta = 4.08, 95%
## CI [2.26, 5.90])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.70, 95% CI [-25.62, 12.22], t(2038) = -0.69, p = 0.487; Std. beta = -1.53,
## 95% CI [-4.07, 1.00])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-24.72, 0.73], t(2038) = -1.85, p = 0.065; Std. beta = -0.53,
## 95% CI [-1.63, 0.56])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-18.43, 4.12], t(2038) = -1.25, p = 0.213; Std. beta = -0.39,
## 95% CI [-1.23, 0.46])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.86, 95% CI [-40.50, 8.79], t(2038) = -1.26, p = 0.207; Std. beta = -0.44,
## 95% CI [-2.01, 1.14])
## - The effect of site [22R] is statistically significant and negative (beta =
## -17.54, 95% CI [-26.49, -8.58], t(2038) = -3.84, p < .001; Std. beta = -0.59,
## 95% CI [-1.27, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -28.69, 95% CI [-43.97, -13.41], t(2038) = -3.68, p < .001; Std. beta = 0.43,
## 95% CI [-4.56, 5.42])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.93, 95% CI [-13.40, 7.54], t(2038) = -0.55, p = 0.583; Std. beta = -0.49,
## 95% CI [-1.21, 0.23])
## - The effect of site [25R] is statistically significant and negative (beta =
## -13.84, 95% CI [-25.56, -2.13], t(2038) = -2.32, p = 0.021; Std. beta = -1.03,
## 95% CI [-1.84, -0.21])
## - The effect of site [28R] is statistically significant and negative (beta =
## -18.60, 95% CI [-34.17, -3.02], t(2038) = -2.34, p = 0.019; Std. beta = -2.13,
## 95% CI [-4.73, 0.46])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -7.91, 95% CI [-33.98, 18.17], t(2038) = -0.59, p = 0.552; Std. beta = -0.64,
## 95% CI [-2.26, 0.98])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-16.79, 6.93], t(2038) = -0.81, p = 0.415; Std. beta = -0.10,
## 95% CI [-0.86, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 0.22, 95% CI [-13.44, 13.88], t(2038) = 0.03, p = 0.975; Std. beta = -0.03,
## 95% CI [-1.00, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -12.20, 95% CI [-25.29, 0.89], t(2038) = -1.83, p = 0.068; Std. beta = -1.20,
## 95% CI [-2.21, -0.20])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -8.76, 95% CI [-18.98, 1.46], t(2038) = -1.68, p = 0.093; Std. beta = -0.48,
## 95% CI [-1.18, 0.23])
## - The effect of site [35R] is statistically significant and negative (beta =
## -18.92, 95% CI [-34.65, -3.20], t(2038) = -2.36, p = 0.018; Std. beta = -0.30,
## 95% CI [-1.43, 0.83])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.43, 95% CI [-12.37, 11.50], t(2038) = -0.07, p = 0.943; Std. beta = 0.52,
## 95% CI [-0.33, 1.38])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -3.93, 95% CI [-17.09, 9.23], t(2038) = -0.59, p = 0.558; Std. beta = -0.36,
## 95% CI [-1.24, 0.53])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.90, 95% CI [-14.05, 4.26], t(2038) = -1.05, p = 0.294; Std. beta = -0.51,
## 95% CI [-1.13, 0.10])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 8.87, 95% CI [-17.62, 35.36], t(2038) = 0.66, p = 0.512; Std. beta = -2.51,
## 95% CI [-4.71, -0.30])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-22.73, 13.97], t(2038) = -0.47, p = 0.640; Std. beta = -0.10,
## 95% CI [-1.44, 1.24])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.64, 95% CI [-34.12, -3.17], t(2038) = -2.36, p = 0.018; Std. beta = -0.77,
## 95% CI [-2.16, 0.61])
## - The effect of site [42R] is statistically significant and negative (beta =
## -14.16, 95% CI [-23.16, -5.16], t(2038) = -3.09, p = 0.002; Std. beta = -1.27,
## 95% CI [-2.39, -0.16])
## - The effect of time firstPFT × SO4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.15, 95% CI [-0.54, 0.85], t(2038) =
## 0.43, p = 0.666; Std. beta = 0.03, 95% CI [-0.10, 0.16])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.64, 3.76], t(2038) = 1.39, p = 0.163; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.54, 95% CI [-2.72, 1.64], t(2038) =
## -0.49, p = 0.625; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.55, 2.02], t(2038) = 1.12, p = 0.264; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.64, 95% CI [-1.97, 0.68], t(2038) =
## -0.95, p = 0.340; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.40, 95% CI [-18.25, 5.45], t(2038) =
## -1.06, p = 0.289; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.17, 95% CI [-1.16, 5.51], t(2038) =
## 1.28, p = 0.201; Std. beta = 0.27, 95% CI [-0.14, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.56, 95% CI [-69.03, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.04, 95% CI [-8.56, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-12.33, 11.48], t(2038) = -0.07, p = 0.944;
## Std. beta = -0.05, 95% CI [-1.53, 1.42])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.22, 95% CI [-14.66, 10.21], t(2038) = -0.35, p = 0.726;
## Std. beta = -0.28, 95% CI [-1.82, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-18.16, 11.64], t(2038) = -0.43, p = 0.668;
## Std. beta = -0.40, 95% CI [-2.25, 1.44])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-5.01, 1.46], t(2038) = -1.08, p = 0.282; Std.
## beta = -0.22, 95% CI [-0.62, 0.18])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.38, 95% CI [-6.11, 10.88], t(2038) = 0.55, p = 0.582; Std.
## beta = 0.30, 95% CI [-0.76, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.49, 95% CI [-3.10, 2.12], t(2038) = -0.37, p = 0.712; Std.
## beta = -0.06, 95% CI [-0.38, 0.26])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-5.30, 4.30], t(2038) = -0.20, p = 0.839; Std.
## beta = -0.06, 95% CI [-0.66, 0.53])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-0.88, 4.82], t(2038) = 1.35, p = 0.176; Std.
## beta = 0.24, 95% CI [-0.11, 0.60])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.40, 9.94], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.67, 1.23])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.21, 95% CI [-2.49, 2.90], t(2038) = 0.15, p = 0.881; Std.
## beta = 0.03, 95% CI [-0.31, 0.36])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.42, 5.70], t(2038) = 1.18, p = 0.238; Std.
## beta = 0.27, 95% CI [-0.18, 0.71])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.23, 95% CI [-28.37, 3.90], t(2038) = -1.49, p = 0.137;
## Std. beta = -1.52, 95% CI [-3.52, 0.48])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.75, 95% CI [-2.55, 12.05], t(2038) = 1.28, p = 0.202; Std.
## beta = 0.59, 95% CI [-0.32, 1.49])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.21, 11.62], t(2038) = 2.03, p = 0.042; Std.
## beta = 0.73, 95% CI [0.03, 1.44])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.13, 95% CI [-5.98, 10.23], t(2038) = 0.51, p = 0.607; Std.
## beta = 0.26, 95% CI [-0.74, 1.27])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.20, 95% CI [-8.16, 7.75], t(2038) = -0.05, p = 0.960; Std.
## beta = -0.03, 95% CI [-1.01, 0.96])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.51, 95% CI [-56.03, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.16, 95% CI [-29.99, 25.68], t(2038) = -0.15, p = 0.879;
## Std. beta = -0.27, 95% CI [-3.72, 3.19])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.05, 95% CI [-6.57, 4.47], t(2038) = -0.37, p = 0.710; Std.
## beta = -0.13, 95% CI [-0.81, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.45, 95% CI [-35.96, 15.07], t(2038) = -0.80, p = 0.422;
## Std. beta = -1.30, 95% CI [-4.46, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.74, 95% CI [-7.08, 12.56], t(2038) = 0.55, p = 0.584; Std.
## beta = 0.34, 95% CI [-0.88, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-5.98, 7.90], t(2038) = 0.27, p = 0.786; Std.
## beta = 0.12, 95% CI [-0.74, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.22, 95% CI [-3.21, 15.66], t(2038) = 1.29, p = 0.196; Std.
## beta = 0.77, 95% CI [-0.40, 1.94])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.84, 95% CI [0.11, 11.58], t(2038) = 2.00, p = 0.046; Std.
## beta = 0.73, 95% CI [0.01, 1.44])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.09, 95% CI [-29.31, 75.49], t(2038) = 0.86, p = 0.388; Std.
## beta = 2.86, 95% CI [-3.64, 9.37])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-8.02, 2.34], t(2038) = -1.07, p = 0.283; Std.
## beta = -0.35, 95% CI [-1.00, 0.29])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-7.08, 5.45], t(2038) = -0.26, p = 0.798; Std.
## beta = -0.10, 95% CI [-0.88, 0.68])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.42, 95% CI [-34.23, 17.38], t(2038) = -0.64, p = 0.522;
## Std. beta = -1.04, 95% CI [-4.25, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.01, 95% CI [-11.23, 9.21], t(2038) = -0.19, p = 0.846; Std.
## beta = -0.13, 95% CI [-1.39, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.28, 95% CI [-1.99, 6.56], t(2038) = 1.05, p = 0.295; Std.
## beta = 0.28, 95% CI [-0.25, 0.81])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.40, 95% CI [-7.69, 6.88], t(2038) = -0.11, p = 0.913; Std.
## beta = -0.05, 95% CI [-0.95, 0.85])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.64, 95% CI [-11.24, 3.97], t(2038) = -0.94, p = 0.348; Std.
## beta = -0.45, 95% CI [-1.39, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.15, 95% CI [-3.79, 6.09], t(2038) = 0.46, p = 0.648; Std.
## beta = 0.14, 95% CI [-0.47, 0.76])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.56, 95% CI [0.28, 18.85], t(2038) = 2.02, p = 0.043; Std.
## beta = 1.19, 95% CI [0.03, 2.34])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.66, 11.35], t(2038) = 1.75, p = 0.081; Std.
## beta = 0.66, 95% CI [-0.08, 1.41])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-6.89, 5.18], t(2038) = -0.28, p = 0.781; Std.
## beta = -0.11, 95% CI [-0.86, 0.64])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.76, 95% CI [-5.76, 2.24], t(2038) = -0.86, p = 0.388; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.13, 95% CI [-50.85, -9.42], t(2038) = -2.85, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.31, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-7.36, 11.16], t(2038) = 0.40, p = 0.688; Std.
## beta = 0.24, 95% CI [-0.91, 1.38])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.77, 95% CI [-8.44, 17.98], t(2038) = 0.71, p = 0.479; Std.
## beta = 0.59, 95% CI [-1.05, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-14.74, 8.72], t(2038) = -0.50, p = 0.615; Std.
## beta = -0.37, 95% CI [-1.83, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*NO3_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15055.9
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1398 -0.4968 -0.0038 0.4359 7.0938
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 140.87 11.869
## time_firstPFT 11.32 3.364 -0.31
## Residual 41.81 6.466
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 47.29214 2.46216 19.208
## time_firstPFT -5.12594 1.31609 -3.895
## NO3_5yrPreCensor -6.33101 2.03481 -3.111
## site02R -0.19947 13.50404 -0.015
## site03R 25.09655 9.82752 2.554
## site04R -1.31651 9.28522 -0.142
## site05R -13.30383 7.71219 -1.725
## site06R 3.46454 9.62361 0.360
## site07R 6.84795 3.67188 1.865
## site09R -10.09296 9.36959 -1.077
## site101 19.10802 2.52766 7.560
## site102 6.46616 4.97311 1.300
## site103 -6.07202 2.58113 -2.352
## site104 -14.61729 5.42230 -2.696
## site105 -0.81898 2.62167 -0.312
## site106 -3.53035 3.34049 -1.057
## site107 8.03911 9.57245 0.840
## site108 -12.16845 7.59355 -1.602
## site10R -5.05666 13.34346 -0.379
## site11R -4.64641 5.88378 -0.790
## site12R -10.44457 9.29206 -1.124
## site13R -11.46027 7.28376 -1.573
## site14R -7.27982 14.94327 -0.487
## site15R -28.03731 13.64232 -2.055
## site16R -8.19019 5.83689 -1.403
## site17R 58.99676 13.55577 4.352
## site18R -8.49959 9.67104 -0.879
## site19R -10.91248 6.36775 -1.714
## site20R -3.89228 5.53668 -0.703
## site21R -15.50944 12.66081 -1.225
## site22R -9.91362 4.23254 -2.342
## site23R -21.72392 6.17530 -3.518
## site24R 3.28523 4.98767 0.659
## site25R -4.42056 5.52366 -0.800
## site28R -16.21977 7.86070 -2.063
## site29R -1.70282 13.24269 -0.129
## site31R -3.24213 5.85905 -0.553
## site32R 1.63214 6.73859 0.242
## site33R -11.40852 6.63994 -1.718
## site34R -6.20282 4.98675 -1.244
## site35R -17.27761 7.89711 -2.188
## site36R 3.90745 5.90710 0.661
## site37R 2.26034 6.44188 0.351
## site38R -5.49525 4.60002 -1.195
## site39R 2.73958 13.25238 0.207
## site40R 5.85271 9.30370 0.629
## site41R -12.79762 7.65743 -1.671
## site42R -8.36462 4.30456 -1.943
## time_firstPFT:NO3_5yrPreCensor 0.78723 1.15249 0.683
## time_firstPFT:site02R -35.05292 18.54998 -1.890
## time_firstPFT:site03R -1.34583 5.94531 -0.226
## time_firstPFT:site04R -2.47289 6.29460 -0.393
## time_firstPFT:site05R -3.65401 7.55858 -0.483
## time_firstPFT:site06R 3.23958 5.06189 0.640
## time_firstPFT:site07R -2.95842 1.41816 -2.086
## time_firstPFT:site09R 1.01587 4.22631 0.240
## time_firstPFT:site101 -0.97010 1.07177 -0.905
## time_firstPFT:site102 -1.46662 2.19237 -0.669
## time_firstPFT:site103 1.64786 1.21004 1.362
## time_firstPFT:site104 2.82855 3.80022 0.744
## time_firstPFT:site105 -0.04422 1.16479 -0.038
## time_firstPFT:site106 1.19166 1.60969 0.740
## time_firstPFT:site107 -13.29947 8.17738 -1.626
## time_firstPFT:site108 4.12255 3.47838 1.185
## time_firstPFT:site11R 5.37503 2.87962 1.867
## time_firstPFT:site12R 1.34477 4.02598 0.334
## time_firstPFT:site13R -0.52521 3.95035 -0.133
## time_firstPFT:site14R -10.91998 23.69092 -0.461
## time_firstPFT:site15R -1.63088 14.19040 -0.115
## time_firstPFT:site16R -1.34951 2.63137 -0.513
## time_firstPFT:site18R -10.39685 12.99272 -0.800
## time_firstPFT:site19R 2.92944 4.93024 0.594
## time_firstPFT:site20R 0.80896 3.40853 0.237
## time_firstPFT:site21R 5.61790 4.80054 1.170
## time_firstPFT:site22R 4.04543 2.77454 1.458
## time_firstPFT:site23R -0.79582 5.43160 -0.147
## time_firstPFT:site24R -3.78529 2.48058 -1.526
## time_firstPFT:site25R -2.55180 2.96765 -0.860
## time_firstPFT:site28R -9.86869 13.06382 -0.755
## time_firstPFT:site29R -2.88863 5.11463 -0.565
## time_firstPFT:site31R 1.49651 2.07191 0.722
## time_firstPFT:site32R -0.94444 3.59402 -0.263
## time_firstPFT:site33R -3.15805 3.82473 -0.826
## time_firstPFT:site34R 0.79715 2.39755 0.332
## time_firstPFT:site35R 8.73640 4.67074 1.870
## time_firstPFT:site36R 4.82780 2.95797 1.632
## time_firstPFT:site37R -1.74144 2.86066 -0.609
## time_firstPFT:site38R -1.74703 2.02640 -0.862
## time_firstPFT:site39R -29.97615 10.46456 -2.865
## time_firstPFT:site40R 1.18503 4.59023 0.258
## time_firstPFT:site41R 3.37621 6.66200 0.507
## time_firstPFT:site42R -3.15846 5.91466 -0.534##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.799
## Unadjusted ICC: 0.529report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NO3_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.34. The model's
## intercept, corresponding to time_firstPFT = 0, is at 47.29 (95% CI [42.46,
## 52.12], t(2068) = 19.21, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.13, 95% CI [-7.71, -2.54], t(2068) = -3.89, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.42])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -6.33, 95% CI [-10.32, -2.34], t(2068) = -3.11, p = 0.002; Std. beta =
## -0.13, 95% CI [-0.25, -0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-26.68, 26.28], t(2068) = -0.01, p = 0.988; Std. beta = -3.62,
## 95% CI [-7.01, -0.22])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.10, 95% CI [5.82, 44.37], t(2068) = 2.55, p = 0.011; Std. beta = 1.57, 95%
## CI [0.31, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.32, 95% CI [-19.53, 16.89], t(2068) = -0.14, p = 0.887; Std. beta = -0.34,
## 95% CI [-1.78, 1.10])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.43, 1.82], t(2068) = -1.73, p = 0.085; Std. beta = -1.28,
## 95% CI [-2.76, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.46, 95% CI [-15.41, 22.34], t(2068) = 0.36, p = 0.719; Std. beta = 0.57,
## 95% CI [-0.79, 1.92])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.85, 95% CI [-0.35, 14.05], t(2068) = 1.86, p = 0.062; Std. beta = 0.16, 95%
## CI [-0.30, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-28.47, 8.28], t(2068) = -1.08, p = 0.282; Std. beta = -0.58,
## 95% CI [-1.84, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.11, 95% CI [14.15, 24.07], t(2068) = 7.56, p < .001; Std. beta = 1.20, 95%
## CI [0.87, 1.53])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.47, 95% CI [-3.29, 16.22], t(2068) = 1.30, p = 0.194; Std. beta = 0.29, 95%
## CI [-0.35, 0.93])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.07, 95% CI [-11.13, -1.01], t(2068) = -2.35, p = 0.019; Std. beta = -0.24,
## 95% CI [-0.60, 0.11])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.62, 95% CI [-25.25, -3.98], t(2068) = -2.70, p = 0.007; Std. beta = -0.70,
## 95% CI [-1.59, 0.18])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-5.96, 4.32], t(2068) = -0.31, p = 0.755; Std. beta = -0.06,
## 95% CI [-0.41, 0.29])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.53, 95% CI [-10.08, 3.02], t(2068) = -1.06, p = 0.291; Std. beta = -0.12,
## 95% CI [-0.55, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.04, 95% CI [-10.73, 26.81], t(2068) = 0.84, p = 0.401; Std. beta = -0.82,
## 95% CI [-2.44, 0.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.17, 95% CI [-27.06, 2.72], t(2068) = -1.60, p = 0.109; Std. beta = -0.40,
## 95% CI [-1.38, 0.57])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -5.06, 95% CI [-31.22, 21.11], t(2068) = -0.38, p = 0.705; Std. beta = -0.34,
## 95% CI [-2.12, 1.44])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -4.65, 95% CI [-16.19, 6.89], t(2068) = -0.79, p = 0.430; Std. beta = 0.24,
## 95% CI [-0.58, 1.05])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.44, 95% CI [-28.67, 7.78], t(2068) = -1.12, p = 0.261; Std. beta = -0.57,
## 95% CI [-1.83, 0.69])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-25.74, 2.82], t(2068) = -1.57, p = 0.116; Std. beta = -0.83,
## 95% CI [-1.78, 0.11])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.28, 95% CI [-36.59, 22.03], t(2068) = -0.49, p = 0.626; Std. beta = -1.62,
## 95% CI [-5.03, 1.79])
## - The effect of site [15R] is statistically significant and negative (beta =
## -28.04, 95% CI [-54.79, -1.28], t(2068) = -2.06, p = 0.040; Std. beta = -2.07,
## 95% CI [-4.70, 0.55])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-19.64, 3.26], t(2068) = -1.40, p = 0.161; Std. beta = -0.70,
## 95% CI [-1.49, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.00, 95% CI [32.41, 85.58], t(2068) = 4.35, p < .001; Std. beta = 4.01, 95%
## CI [2.20, 5.82])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.50, 95% CI [-27.47, 10.47], t(2068) = -0.88, p = 0.380; Std. beta = -1.65,
## 95% CI [-4.17, 0.87])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-23.40, 1.58], t(2068) = -1.71, p = 0.087; Std. beta = -0.44,
## 95% CI [-1.51, 0.63])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-14.75, 6.97], t(2068) = -0.70, p = 0.482; Std. beta = -0.18,
## 95% CI [-0.99, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.51, 95% CI [-40.34, 9.32], t(2068) = -1.22, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.05, 1.09])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.91, 95% CI [-18.21, -1.61], t(2068) = -2.34, p = 0.019; Std. beta = -0.26,
## 95% CI [-0.89, 0.37])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.72, 95% CI [-33.83, -9.61], t(2068) = -3.52, p < .001; Std. beta = -1.56,
## 95% CI [-2.73, -0.39])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-6.50, 13.07], t(2068) = 0.66, p = 0.510; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-15.25, 6.41], t(2068) = -0.80, p = 0.424; Std. beta = -0.56,
## 95% CI [-1.31, 0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.22, 95% CI [-31.64, -0.80], t(2068) = -2.06, p = 0.039; Std. beta = -2.12,
## 95% CI [-4.68, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-27.67, 24.27], t(2068) = -0.13, p = 0.898; Std. beta = -0.41,
## 95% CI [-2.00, 1.18])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-14.73, 8.25], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.80, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.63, 95% CI [-11.58, 14.85], t(2068) = 0.24, p = 0.809; Std. beta = 0.01,
## 95% CI [-0.91, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.41, 95% CI [-24.43, 1.61], t(2068) = -1.72, p = 0.086; Std. beta = -1.10,
## 95% CI [-2.09, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.20, 95% CI [-15.98, 3.58], t(2068) = -1.24, p = 0.214; Std. beta = -0.34,
## 95% CI [-1.01, 0.33])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.28, 95% CI [-32.76, -1.79], t(2068) = -2.19, p = 0.029; Std. beta = -0.28,
## 95% CI [-1.38, 0.82])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.91, 95% CI [-7.68, 15.49], t(2068) = 0.66, p = 0.508; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.37, 14.89], t(2068) = 0.35, p = 0.726; Std. beta = -0.03,
## 95% CI [-0.86, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-14.52, 3.53], t(2068) = -1.19, p = 0.232; Std. beta = -0.55,
## 95% CI [-1.15, 0.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-23.25, 28.73], t(2068) = 0.21, p = 0.836; Std. beta = -2.90,
## 95% CI [-5.05, -0.74])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-12.39, 24.10], t(2068) = 0.63, p = 0.529; Std. beta = 0.52,
## 95% CI [-0.79, 1.83])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-27.81, 2.22], t(2068) = -1.67, p = 0.095; Std. beta = -0.52,
## 95% CI [-1.88, 0.83])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.36, 95% CI [-16.81, 0.08], t(2068) = -1.94, p = 0.052; Std. beta = -0.89,
## 95% CI [-1.97, 0.19])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.79, 95% CI [-1.47, 3.05], t(2068) =
## 0.68, p = 0.495; Std. beta = 0.04, 95% CI [-0.07, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.43, 1.33], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.34, 95% CI [-8.85, 0.16])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-13.01, 10.31], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-14.82, 9.87], t(2068) = -0.39, p = 0.694; Std.
## beta = -0.31, 95% CI [-1.84, 1.22])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.65, 95% CI [-18.48, 11.17], t(2068) = -0.48, p = 0.629;
## Std. beta = -0.45, 95% CI [-2.29, 1.38])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.69, 13.17], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.74, -0.18], t(2068) = -2.09, p = 0.037; Std.
## beta = -0.37, 95% CI [-0.71, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.27, 9.30], t(2068) = 0.24, p = 0.810; Std.
## beta = 0.13, 95% CI [-0.90, 1.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-3.07, 1.13], t(2068) = -0.91, p = 0.365; Std.
## beta = -0.12, 95% CI [-0.38, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.77, 2.83], t(2068) = -0.67, p = 0.504; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.73, 4.02], t(2068) = 1.36, p = 0.173; Std.
## beta = 0.20, 95% CI [-0.09, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.62, 10.28], t(2068) = 0.74, p = 0.457; Std.
## beta = 0.35, 95% CI [-0.57, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.33, 2.24], t(2068) = -0.04, p = 0.970; Std.
## beta = -5.48e-03, 95% CI [-0.29, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-1.97, 4.35], t(2068) = 0.74, p = 0.459; Std.
## beta = 0.15, 95% CI [-0.24, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.30, 95% CI [-29.34, 2.74], t(2068) = -1.63, p = 0.104;
## Std. beta = -1.65, 95% CI [-3.63, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.12, 95% CI [-2.70, 10.94], t(2068) = 1.19, p = 0.236; Std.
## beta = 0.51, 95% CI [-0.33, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.38, 95% CI [-0.27, 11.02], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.67, 95% CI [-0.03, 1.37])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.55, 9.24], t(2068) = 0.33, p = 0.738; Std.
## beta = 0.17, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.27, 7.22], t(2068) = -0.13, p = 0.894; Std.
## beta = -0.07, 95% CI [-1.02, 0.89])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-57.38, 35.54], t(2068) = -0.46, p = 0.645;
## Std. beta = -1.35, 95% CI [-7.11, 4.40])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-29.46, 26.20], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.20, 95% CI [-3.65, 3.25])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-6.51, 3.81], t(2068) = -0.51, p = 0.608; Std.
## beta = -0.17, 95% CI [-0.81, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-35.88, 15.08], t(2068) = -0.80, p = 0.424;
## Std. beta = -1.29, 95% CI [-4.44, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-6.74, 12.60], t(2068) = 0.59, p = 0.552; Std.
## beta = 0.36, 95% CI [-0.83, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.81, 95% CI [-5.88, 7.49], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.10, 95% CI [-0.73, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.62, 95% CI [-3.80, 15.03], t(2068) = 1.17, p = 0.242; Std.
## beta = 0.70, 95% CI [-0.47, 1.86])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.40, 9.49], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.50, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-11.45, 9.86], t(2068) = -0.15, p = 0.884; Std.
## beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.65, 1.08], t(2068) = -1.53, p = 0.127; Std.
## beta = -0.47, 95% CI [-1.07, 0.13])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-8.37, 3.27], t(2068) = -0.86, p = 0.390; Std.
## beta = -0.32, 95% CI [-1.04, 0.40])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.87, 95% CI [-35.49, 15.75], t(2068) = -0.76, p = 0.450;
## Std. beta = -1.22, 95% CI [-4.40, 1.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-12.92, 7.14], t(2068) = -0.56, p = 0.572; Std.
## beta = -0.36, 95% CI [-1.60, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-2.57, 5.56], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.19, 95% CI [-0.32, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-7.99, 6.10], t(2068) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.99, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-10.66, 4.34], t(2068) = -0.83, p = 0.409; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.90, 5.50], t(2068) = 0.33, p = 0.740; Std.
## beta = 0.10, 95% CI [-0.48, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.74, 95% CI [-0.42, 17.90], t(2068) = 1.87, p = 0.062; Std.
## beta = 1.08, 95% CI [-0.05, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-0.97, 10.63], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.74, 95% CI [-7.35, 3.87], t(2068) = -0.61, p = 0.543; Std.
## beta = -0.22, 95% CI [-0.91, 0.48])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.72, 2.23], t(2068) = -0.86, p = 0.389; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.98, 95% CI [-50.50, -9.45], t(2068) = -2.86, p = 0.004;
## Std. beta = -3.71, 95% CI [-6.26, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-7.82, 10.19], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-9.69, 16.44], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.42, 95% CI [-1.20, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-14.76, 8.44], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.83, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NO3_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to NO3_5yrPreCensor = 0, is at 47.29 (95% CI [42.46, 52.12],
## t(2068) = 19.21, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.13, 95% CI [-7.71, -2.54], t(2068) = -3.89, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.42])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -6.33, 95% CI [-10.32, -2.34], t(2068) = -3.11, p = 0.002; Std. beta =
## -0.13, 95% CI [-0.25, -0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-26.68, 26.28], t(2068) = -0.01, p = 0.988; Std. beta = -3.62,
## 95% CI [-7.01, -0.22])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.10, 95% CI [5.82, 44.37], t(2068) = 2.55, p = 0.011; Std. beta = 1.57, 95%
## CI [0.31, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.32, 95% CI [-19.53, 16.89], t(2068) = -0.14, p = 0.887; Std. beta = -0.34,
## 95% CI [-1.78, 1.10])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.43, 1.82], t(2068) = -1.73, p = 0.085; Std. beta = -1.28,
## 95% CI [-2.76, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.46, 95% CI [-15.41, 22.34], t(2068) = 0.36, p = 0.719; Std. beta = 0.57,
## 95% CI [-0.79, 1.92])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.85, 95% CI [-0.35, 14.05], t(2068) = 1.86, p = 0.062; Std. beta = 0.16, 95%
## CI [-0.30, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-28.47, 8.28], t(2068) = -1.08, p = 0.282; Std. beta = -0.58,
## 95% CI [-1.84, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.11, 95% CI [14.15, 24.07], t(2068) = 7.56, p < .001; Std. beta = 1.20, 95%
## CI [0.87, 1.53])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.47, 95% CI [-3.29, 16.22], t(2068) = 1.30, p = 0.194; Std. beta = 0.29, 95%
## CI [-0.35, 0.93])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.07, 95% CI [-11.13, -1.01], t(2068) = -2.35, p = 0.019; Std. beta = -0.24,
## 95% CI [-0.60, 0.11])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.62, 95% CI [-25.25, -3.98], t(2068) = -2.70, p = 0.007; Std. beta = -0.70,
## 95% CI [-1.59, 0.18])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-5.96, 4.32], t(2068) = -0.31, p = 0.755; Std. beta = -0.06,
## 95% CI [-0.41, 0.29])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.53, 95% CI [-10.08, 3.02], t(2068) = -1.06, p = 0.291; Std. beta = -0.12,
## 95% CI [-0.55, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.04, 95% CI [-10.73, 26.81], t(2068) = 0.84, p = 0.401; Std. beta = -0.82,
## 95% CI [-2.44, 0.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.17, 95% CI [-27.06, 2.72], t(2068) = -1.60, p = 0.109; Std. beta = -0.40,
## 95% CI [-1.38, 0.57])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -5.06, 95% CI [-31.22, 21.11], t(2068) = -0.38, p = 0.705; Std. beta = -0.34,
## 95% CI [-2.12, 1.44])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -4.65, 95% CI [-16.19, 6.89], t(2068) = -0.79, p = 0.430; Std. beta = 0.24,
## 95% CI [-0.58, 1.05])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.44, 95% CI [-28.67, 7.78], t(2068) = -1.12, p = 0.261; Std. beta = -0.57,
## 95% CI [-1.83, 0.69])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-25.74, 2.82], t(2068) = -1.57, p = 0.116; Std. beta = -0.83,
## 95% CI [-1.78, 0.11])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.28, 95% CI [-36.59, 22.03], t(2068) = -0.49, p = 0.626; Std. beta = -1.62,
## 95% CI [-5.03, 1.79])
## - The effect of site [15R] is statistically significant and negative (beta =
## -28.04, 95% CI [-54.79, -1.28], t(2068) = -2.06, p = 0.040; Std. beta = -2.07,
## 95% CI [-4.70, 0.55])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-19.64, 3.26], t(2068) = -1.40, p = 0.161; Std. beta = -0.70,
## 95% CI [-1.49, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.00, 95% CI [32.41, 85.58], t(2068) = 4.35, p < .001; Std. beta = 4.01, 95%
## CI [2.20, 5.82])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.50, 95% CI [-27.47, 10.47], t(2068) = -0.88, p = 0.380; Std. beta = -1.65,
## 95% CI [-4.17, 0.87])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-23.40, 1.58], t(2068) = -1.71, p = 0.087; Std. beta = -0.44,
## 95% CI [-1.51, 0.63])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-14.75, 6.97], t(2068) = -0.70, p = 0.482; Std. beta = -0.18,
## 95% CI [-0.99, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.51, 95% CI [-40.34, 9.32], t(2068) = -1.22, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.05, 1.09])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.91, 95% CI [-18.21, -1.61], t(2068) = -2.34, p = 0.019; Std. beta = -0.26,
## 95% CI [-0.89, 0.37])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.72, 95% CI [-33.83, -9.61], t(2068) = -3.52, p < .001; Std. beta = -1.56,
## 95% CI [-2.73, -0.39])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-6.50, 13.07], t(2068) = 0.66, p = 0.510; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-15.25, 6.41], t(2068) = -0.80, p = 0.424; Std. beta = -0.56,
## 95% CI [-1.31, 0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.22, 95% CI [-31.64, -0.80], t(2068) = -2.06, p = 0.039; Std. beta = -2.12,
## 95% CI [-4.68, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-27.67, 24.27], t(2068) = -0.13, p = 0.898; Std. beta = -0.41,
## 95% CI [-2.00, 1.18])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-14.73, 8.25], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.80, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.63, 95% CI [-11.58, 14.85], t(2068) = 0.24, p = 0.809; Std. beta = 0.01,
## 95% CI [-0.91, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.41, 95% CI [-24.43, 1.61], t(2068) = -1.72, p = 0.086; Std. beta = -1.10,
## 95% CI [-2.09, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.20, 95% CI [-15.98, 3.58], t(2068) = -1.24, p = 0.214; Std. beta = -0.34,
## 95% CI [-1.01, 0.33])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.28, 95% CI [-32.76, -1.79], t(2068) = -2.19, p = 0.029; Std. beta = -0.28,
## 95% CI [-1.38, 0.82])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.91, 95% CI [-7.68, 15.49], t(2068) = 0.66, p = 0.508; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.37, 14.89], t(2068) = 0.35, p = 0.726; Std. beta = -0.03,
## 95% CI [-0.86, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-14.52, 3.53], t(2068) = -1.19, p = 0.232; Std. beta = -0.55,
## 95% CI [-1.15, 0.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-23.25, 28.73], t(2068) = 0.21, p = 0.836; Std. beta = -2.90,
## 95% CI [-5.05, -0.74])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-12.39, 24.10], t(2068) = 0.63, p = 0.529; Std. beta = 0.52,
## 95% CI [-0.79, 1.83])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-27.81, 2.22], t(2068) = -1.67, p = 0.095; Std. beta = -0.52,
## 95% CI [-1.88, 0.83])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.36, 95% CI [-16.81, 0.08], t(2068) = -1.94, p = 0.052; Std. beta = -0.89,
## 95% CI [-1.97, 0.19])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.79, 95% CI [-1.47, 3.05], t(2068) =
## 0.68, p = 0.495; Std. beta = 0.04, 95% CI [-0.07, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.43, 1.33], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.34, 95% CI [-8.85, 0.16])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-13.01, 10.31], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-14.82, 9.87], t(2068) = -0.39, p = 0.694; Std.
## beta = -0.31, 95% CI [-1.84, 1.22])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.65, 95% CI [-18.48, 11.17], t(2068) = -0.48, p = 0.629;
## Std. beta = -0.45, 95% CI [-2.29, 1.38])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.69, 13.17], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.74, -0.18], t(2068) = -2.09, p = 0.037; Std.
## beta = -0.37, 95% CI [-0.71, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.27, 9.30], t(2068) = 0.24, p = 0.810; Std.
## beta = 0.13, 95% CI [-0.90, 1.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-3.07, 1.13], t(2068) = -0.91, p = 0.365; Std.
## beta = -0.12, 95% CI [-0.38, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.77, 2.83], t(2068) = -0.67, p = 0.504; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.73, 4.02], t(2068) = 1.36, p = 0.173; Std.
## beta = 0.20, 95% CI [-0.09, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.62, 10.28], t(2068) = 0.74, p = 0.457; Std.
## beta = 0.35, 95% CI [-0.57, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.33, 2.24], t(2068) = -0.04, p = 0.970; Std.
## beta = -5.48e-03, 95% CI [-0.29, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-1.97, 4.35], t(2068) = 0.74, p = 0.459; Std.
## beta = 0.15, 95% CI [-0.24, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.30, 95% CI [-29.34, 2.74], t(2068) = -1.63, p = 0.104;
## Std. beta = -1.65, 95% CI [-3.63, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.12, 95% CI [-2.70, 10.94], t(2068) = 1.19, p = 0.236; Std.
## beta = 0.51, 95% CI [-0.33, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.38, 95% CI [-0.27, 11.02], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.67, 95% CI [-0.03, 1.37])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.55, 9.24], t(2068) = 0.33, p = 0.738; Std.
## beta = 0.17, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.27, 7.22], t(2068) = -0.13, p = 0.894; Std.
## beta = -0.07, 95% CI [-1.02, 0.89])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-57.38, 35.54], t(2068) = -0.46, p = 0.645;
## Std. beta = -1.35, 95% CI [-7.11, 4.40])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-29.46, 26.20], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.20, 95% CI [-3.65, 3.25])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-6.51, 3.81], t(2068) = -0.51, p = 0.608; Std.
## beta = -0.17, 95% CI [-0.81, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-35.88, 15.08], t(2068) = -0.80, p = 0.424;
## Std. beta = -1.29, 95% CI [-4.44, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-6.74, 12.60], t(2068) = 0.59, p = 0.552; Std.
## beta = 0.36, 95% CI [-0.83, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.81, 95% CI [-5.88, 7.49], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.10, 95% CI [-0.73, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.62, 95% CI [-3.80, 15.03], t(2068) = 1.17, p = 0.242; Std.
## beta = 0.70, 95% CI [-0.47, 1.86])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.40, 9.49], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.50, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-11.45, 9.86], t(2068) = -0.15, p = 0.884; Std.
## beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.65, 1.08], t(2068) = -1.53, p = 0.127; Std.
## beta = -0.47, 95% CI [-1.07, 0.13])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-8.37, 3.27], t(2068) = -0.86, p = 0.390; Std.
## beta = -0.32, 95% CI [-1.04, 0.40])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.87, 95% CI [-35.49, 15.75], t(2068) = -0.76, p = 0.450;
## Std. beta = -1.22, 95% CI [-4.40, 1.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-12.92, 7.14], t(2068) = -0.56, p = 0.572; Std.
## beta = -0.36, 95% CI [-1.60, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-2.57, 5.56], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.19, 95% CI [-0.32, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-7.99, 6.10], t(2068) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.99, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-10.66, 4.34], t(2068) = -0.83, p = 0.409; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.90, 5.50], t(2068) = 0.33, p = 0.740; Std.
## beta = 0.10, 95% CI [-0.48, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.74, 95% CI [-0.42, 17.90], t(2068) = 1.87, p = 0.062; Std.
## beta = 1.08, 95% CI [-0.05, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-0.97, 10.63], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.74, 95% CI [-7.35, 3.87], t(2068) = -0.61, p = 0.543; Std.
## beta = -0.22, 95% CI [-0.91, 0.48])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.72, 2.23], t(2068) = -0.86, p = 0.389; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.98, 95% CI [-50.50, -9.45], t(2068) = -2.86, p = 0.004;
## Std. beta = -3.71, 95% CI [-6.26, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-7.82, 10.19], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-9.69, 16.44], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.42, 95% CI [-1.20, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-14.76, 8.44], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.83, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.34. The model's intercept, corresponding to site =
## Simmons, is at 47.29 (95% CI [42.46, 52.12], t(2068) = 19.21, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.13, 95% CI [-7.71, -2.54], t(2068) = -3.89, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.42])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -6.33, 95% CI [-10.32, -2.34], t(2068) = -3.11, p = 0.002; Std. beta =
## -0.13, 95% CI [-0.25, -0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-26.68, 26.28], t(2068) = -0.01, p = 0.988; Std. beta = -3.62,
## 95% CI [-7.01, -0.22])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.10, 95% CI [5.82, 44.37], t(2068) = 2.55, p = 0.011; Std. beta = 1.57, 95%
## CI [0.31, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.32, 95% CI [-19.53, 16.89], t(2068) = -0.14, p = 0.887; Std. beta = -0.34,
## 95% CI [-1.78, 1.10])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.43, 1.82], t(2068) = -1.73, p = 0.085; Std. beta = -1.28,
## 95% CI [-2.76, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.46, 95% CI [-15.41, 22.34], t(2068) = 0.36, p = 0.719; Std. beta = 0.57,
## 95% CI [-0.79, 1.92])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.85, 95% CI [-0.35, 14.05], t(2068) = 1.86, p = 0.062; Std. beta = 0.16, 95%
## CI [-0.30, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-28.47, 8.28], t(2068) = -1.08, p = 0.282; Std. beta = -0.58,
## 95% CI [-1.84, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.11, 95% CI [14.15, 24.07], t(2068) = 7.56, p < .001; Std. beta = 1.20, 95%
## CI [0.87, 1.53])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.47, 95% CI [-3.29, 16.22], t(2068) = 1.30, p = 0.194; Std. beta = 0.29, 95%
## CI [-0.35, 0.93])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.07, 95% CI [-11.13, -1.01], t(2068) = -2.35, p = 0.019; Std. beta = -0.24,
## 95% CI [-0.60, 0.11])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.62, 95% CI [-25.25, -3.98], t(2068) = -2.70, p = 0.007; Std. beta = -0.70,
## 95% CI [-1.59, 0.18])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-5.96, 4.32], t(2068) = -0.31, p = 0.755; Std. beta = -0.06,
## 95% CI [-0.41, 0.29])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.53, 95% CI [-10.08, 3.02], t(2068) = -1.06, p = 0.291; Std. beta = -0.12,
## 95% CI [-0.55, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.04, 95% CI [-10.73, 26.81], t(2068) = 0.84, p = 0.401; Std. beta = -0.82,
## 95% CI [-2.44, 0.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.17, 95% CI [-27.06, 2.72], t(2068) = -1.60, p = 0.109; Std. beta = -0.40,
## 95% CI [-1.38, 0.57])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -5.06, 95% CI [-31.22, 21.11], t(2068) = -0.38, p = 0.705; Std. beta = -0.34,
## 95% CI [-2.12, 1.44])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -4.65, 95% CI [-16.19, 6.89], t(2068) = -0.79, p = 0.430; Std. beta = 0.24,
## 95% CI [-0.58, 1.05])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.44, 95% CI [-28.67, 7.78], t(2068) = -1.12, p = 0.261; Std. beta = -0.57,
## 95% CI [-1.83, 0.69])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-25.74, 2.82], t(2068) = -1.57, p = 0.116; Std. beta = -0.83,
## 95% CI [-1.78, 0.11])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.28, 95% CI [-36.59, 22.03], t(2068) = -0.49, p = 0.626; Std. beta = -1.62,
## 95% CI [-5.03, 1.79])
## - The effect of site [15R] is statistically significant and negative (beta =
## -28.04, 95% CI [-54.79, -1.28], t(2068) = -2.06, p = 0.040; Std. beta = -2.07,
## 95% CI [-4.70, 0.55])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-19.64, 3.26], t(2068) = -1.40, p = 0.161; Std. beta = -0.70,
## 95% CI [-1.49, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.00, 95% CI [32.41, 85.58], t(2068) = 4.35, p < .001; Std. beta = 4.01, 95%
## CI [2.20, 5.82])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.50, 95% CI [-27.47, 10.47], t(2068) = -0.88, p = 0.380; Std. beta = -1.65,
## 95% CI [-4.17, 0.87])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-23.40, 1.58], t(2068) = -1.71, p = 0.087; Std. beta = -0.44,
## 95% CI [-1.51, 0.63])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-14.75, 6.97], t(2068) = -0.70, p = 0.482; Std. beta = -0.18,
## 95% CI [-0.99, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.51, 95% CI [-40.34, 9.32], t(2068) = -1.22, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.05, 1.09])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.91, 95% CI [-18.21, -1.61], t(2068) = -2.34, p = 0.019; Std. beta = -0.26,
## 95% CI [-0.89, 0.37])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.72, 95% CI [-33.83, -9.61], t(2068) = -3.52, p < .001; Std. beta = -1.56,
## 95% CI [-2.73, -0.39])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-6.50, 13.07], t(2068) = 0.66, p = 0.510; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-15.25, 6.41], t(2068) = -0.80, p = 0.424; Std. beta = -0.56,
## 95% CI [-1.31, 0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.22, 95% CI [-31.64, -0.80], t(2068) = -2.06, p = 0.039; Std. beta = -2.12,
## 95% CI [-4.68, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-27.67, 24.27], t(2068) = -0.13, p = 0.898; Std. beta = -0.41,
## 95% CI [-2.00, 1.18])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-14.73, 8.25], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.80, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.63, 95% CI [-11.58, 14.85], t(2068) = 0.24, p = 0.809; Std. beta = 0.01,
## 95% CI [-0.91, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.41, 95% CI [-24.43, 1.61], t(2068) = -1.72, p = 0.086; Std. beta = -1.10,
## 95% CI [-2.09, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.20, 95% CI [-15.98, 3.58], t(2068) = -1.24, p = 0.214; Std. beta = -0.34,
## 95% CI [-1.01, 0.33])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.28, 95% CI [-32.76, -1.79], t(2068) = -2.19, p = 0.029; Std. beta = -0.28,
## 95% CI [-1.38, 0.82])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.91, 95% CI [-7.68, 15.49], t(2068) = 0.66, p = 0.508; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.37, 14.89], t(2068) = 0.35, p = 0.726; Std. beta = -0.03,
## 95% CI [-0.86, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-14.52, 3.53], t(2068) = -1.19, p = 0.232; Std. beta = -0.55,
## 95% CI [-1.15, 0.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-23.25, 28.73], t(2068) = 0.21, p = 0.836; Std. beta = -2.90,
## 95% CI [-5.05, -0.74])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-12.39, 24.10], t(2068) = 0.63, p = 0.529; Std. beta = 0.52,
## 95% CI [-0.79, 1.83])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-27.81, 2.22], t(2068) = -1.67, p = 0.095; Std. beta = -0.52,
## 95% CI [-1.88, 0.83])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.36, 95% CI [-16.81, 0.08], t(2068) = -1.94, p = 0.052; Std. beta = -0.89,
## 95% CI [-1.97, 0.19])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.79, 95% CI [-1.47, 3.05], t(2068) =
## 0.68, p = 0.495; Std. beta = 0.04, 95% CI [-0.07, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.43, 1.33], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.34, 95% CI [-8.85, 0.16])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-13.01, 10.31], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-14.82, 9.87], t(2068) = -0.39, p = 0.694; Std.
## beta = -0.31, 95% CI [-1.84, 1.22])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.65, 95% CI [-18.48, 11.17], t(2068) = -0.48, p = 0.629;
## Std. beta = -0.45, 95% CI [-2.29, 1.38])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.69, 13.17], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.74, -0.18], t(2068) = -2.09, p = 0.037; Std.
## beta = -0.37, 95% CI [-0.71, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.27, 9.30], t(2068) = 0.24, p = 0.810; Std.
## beta = 0.13, 95% CI [-0.90, 1.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-3.07, 1.13], t(2068) = -0.91, p = 0.365; Std.
## beta = -0.12, 95% CI [-0.38, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.77, 2.83], t(2068) = -0.67, p = 0.504; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.73, 4.02], t(2068) = 1.36, p = 0.173; Std.
## beta = 0.20, 95% CI [-0.09, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.62, 10.28], t(2068) = 0.74, p = 0.457; Std.
## beta = 0.35, 95% CI [-0.57, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.33, 2.24], t(2068) = -0.04, p = 0.970; Std.
## beta = -5.48e-03, 95% CI [-0.29, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-1.97, 4.35], t(2068) = 0.74, p = 0.459; Std.
## beta = 0.15, 95% CI [-0.24, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.30, 95% CI [-29.34, 2.74], t(2068) = -1.63, p = 0.104;
## Std. beta = -1.65, 95% CI [-3.63, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.12, 95% CI [-2.70, 10.94], t(2068) = 1.19, p = 0.236; Std.
## beta = 0.51, 95% CI [-0.33, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.38, 95% CI [-0.27, 11.02], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.67, 95% CI [-0.03, 1.37])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.55, 9.24], t(2068) = 0.33, p = 0.738; Std.
## beta = 0.17, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.27, 7.22], t(2068) = -0.13, p = 0.894; Std.
## beta = -0.07, 95% CI [-1.02, 0.89])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-57.38, 35.54], t(2068) = -0.46, p = 0.645;
## Std. beta = -1.35, 95% CI [-7.11, 4.40])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-29.46, 26.20], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.20, 95% CI [-3.65, 3.25])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-6.51, 3.81], t(2068) = -0.51, p = 0.608; Std.
## beta = -0.17, 95% CI [-0.81, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-35.88, 15.08], t(2068) = -0.80, p = 0.424;
## Std. beta = -1.29, 95% CI [-4.44, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-6.74, 12.60], t(2068) = 0.59, p = 0.552; Std.
## beta = 0.36, 95% CI [-0.83, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.81, 95% CI [-5.88, 7.49], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.10, 95% CI [-0.73, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.62, 95% CI [-3.80, 15.03], t(2068) = 1.17, p = 0.242; Std.
## beta = 0.70, 95% CI [-0.47, 1.86])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.40, 9.49], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.50, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-11.45, 9.86], t(2068) = -0.15, p = 0.884; Std.
## beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.65, 1.08], t(2068) = -1.53, p = 0.127; Std.
## beta = -0.47, 95% CI [-1.07, 0.13])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-8.37, 3.27], t(2068) = -0.86, p = 0.390; Std.
## beta = -0.32, 95% CI [-1.04, 0.40])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.87, 95% CI [-35.49, 15.75], t(2068) = -0.76, p = 0.450;
## Std. beta = -1.22, 95% CI [-4.40, 1.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-12.92, 7.14], t(2068) = -0.56, p = 0.572; Std.
## beta = -0.36, 95% CI [-1.60, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-2.57, 5.56], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.19, 95% CI [-0.32, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-7.99, 6.10], t(2068) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.99, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-10.66, 4.34], t(2068) = -0.83, p = 0.409; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.90, 5.50], t(2068) = 0.33, p = 0.740; Std.
## beta = 0.10, 95% CI [-0.48, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.74, 95% CI [-0.42, 17.90], t(2068) = 1.87, p = 0.062; Std.
## beta = 1.08, 95% CI [-0.05, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-0.97, 10.63], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.74, 95% CI [-7.35, 3.87], t(2068) = -0.61, p = 0.543; Std.
## beta = -0.22, 95% CI [-0.91, 0.48])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.72, 2.23], t(2068) = -0.86, p = 0.389; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.98, 95% CI [-50.50, -9.45], t(2068) = -2.86, p = 0.004;
## Std. beta = -3.71, 95% CI [-6.26, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-7.82, 10.19], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-9.69, 16.44], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.42, 95% CI [-1.20, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-14.76, 8.44], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.83, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to cohort = CARE-PF, is at 47.29 (95% CI [42.46, 52.12], t(2068)
## = 19.21, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.13, 95% CI [-7.71, -2.54], t(2068) = -3.89, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.42])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -6.33, 95% CI [-10.32, -2.34], t(2068) = -3.11, p = 0.002; Std. beta =
## -0.13, 95% CI [-0.25, -0.02])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-26.68, 26.28], t(2068) = -0.01, p = 0.988; Std. beta = -3.62,
## 95% CI [-7.01, -0.22])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.10, 95% CI [5.82, 44.37], t(2068) = 2.55, p = 0.011; Std. beta = 1.57, 95%
## CI [0.31, 2.82])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.32, 95% CI [-19.53, 16.89], t(2068) = -0.14, p = 0.887; Std. beta = -0.34,
## 95% CI [-1.78, 1.10])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.43, 1.82], t(2068) = -1.73, p = 0.085; Std. beta = -1.28,
## 95% CI [-2.76, 0.20])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 3.46, 95% CI [-15.41, 22.34], t(2068) = 0.36, p = 0.719; Std. beta = 0.57,
## 95% CI [-0.79, 1.92])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 6.85, 95% CI [-0.35, 14.05], t(2068) = 1.86, p = 0.062; Std. beta = 0.16, 95%
## CI [-0.30, 0.63])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -10.09, 95% CI [-28.47, 8.28], t(2068) = -1.08, p = 0.282; Std. beta = -0.58,
## 95% CI [-1.84, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.11, 95% CI [14.15, 24.07], t(2068) = 7.56, p < .001; Std. beta = 1.20, 95%
## CI [0.87, 1.53])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 6.47, 95% CI [-3.29, 16.22], t(2068) = 1.30, p = 0.194; Std. beta = 0.29, 95%
## CI [-0.35, 0.93])
## - The effect of site [103] is statistically significant and negative (beta =
## -6.07, 95% CI [-11.13, -1.01], t(2068) = -2.35, p = 0.019; Std. beta = -0.24,
## 95% CI [-0.60, 0.11])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.62, 95% CI [-25.25, -3.98], t(2068) = -2.70, p = 0.007; Std. beta = -0.70,
## 95% CI [-1.59, 0.18])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.82, 95% CI [-5.96, 4.32], t(2068) = -0.31, p = 0.755; Std. beta = -0.06,
## 95% CI [-0.41, 0.29])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.53, 95% CI [-10.08, 3.02], t(2068) = -1.06, p = 0.291; Std. beta = -0.12,
## 95% CI [-0.55, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.04, 95% CI [-10.73, 26.81], t(2068) = 0.84, p = 0.401; Std. beta = -0.82,
## 95% CI [-2.44, 0.80])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -12.17, 95% CI [-27.06, 2.72], t(2068) = -1.60, p = 0.109; Std. beta = -0.40,
## 95% CI [-1.38, 0.57])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -5.06, 95% CI [-31.22, 21.11], t(2068) = -0.38, p = 0.705; Std. beta = -0.34,
## 95% CI [-2.12, 1.44])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -4.65, 95% CI [-16.19, 6.89], t(2068) = -0.79, p = 0.430; Std. beta = 0.24,
## 95% CI [-0.58, 1.05])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -10.44, 95% CI [-28.67, 7.78], t(2068) = -1.12, p = 0.261; Std. beta = -0.57,
## 95% CI [-1.83, 0.69])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.46, 95% CI [-25.74, 2.82], t(2068) = -1.57, p = 0.116; Std. beta = -0.83,
## 95% CI [-1.78, 0.11])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.28, 95% CI [-36.59, 22.03], t(2068) = -0.49, p = 0.626; Std. beta = -1.62,
## 95% CI [-5.03, 1.79])
## - The effect of site [15R] is statistically significant and negative (beta =
## -28.04, 95% CI [-54.79, -1.28], t(2068) = -2.06, p = 0.040; Std. beta = -2.07,
## 95% CI [-4.70, 0.55])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.19, 95% CI [-19.64, 3.26], t(2068) = -1.40, p = 0.161; Std. beta = -0.70,
## 95% CI [-1.49, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.00, 95% CI [32.41, 85.58], t(2068) = 4.35, p < .001; Std. beta = 4.01, 95%
## CI [2.20, 5.82])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.50, 95% CI [-27.47, 10.47], t(2068) = -0.88, p = 0.380; Std. beta = -1.65,
## 95% CI [-4.17, 0.87])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-23.40, 1.58], t(2068) = -1.71, p = 0.087; Std. beta = -0.44,
## 95% CI [-1.51, 0.63])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.89, 95% CI [-14.75, 6.97], t(2068) = -0.70, p = 0.482; Std. beta = -0.18,
## 95% CI [-0.99, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -15.51, 95% CI [-40.34, 9.32], t(2068) = -1.22, p = 0.221; Std. beta = -0.48,
## 95% CI [-2.05, 1.09])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.91, 95% CI [-18.21, -1.61], t(2068) = -2.34, p = 0.019; Std. beta = -0.26,
## 95% CI [-0.89, 0.37])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.72, 95% CI [-33.83, -9.61], t(2068) = -3.52, p < .001; Std. beta = -1.56,
## 95% CI [-2.73, -0.39])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-6.50, 13.07], t(2068) = 0.66, p = 0.510; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-15.25, 6.41], t(2068) = -0.80, p = 0.424; Std. beta = -0.56,
## 95% CI [-1.31, 0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.22, 95% CI [-31.64, -0.80], t(2068) = -2.06, p = 0.039; Std. beta = -2.12,
## 95% CI [-4.68, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.70, 95% CI [-27.67, 24.27], t(2068) = -0.13, p = 0.898; Std. beta = -0.41,
## 95% CI [-2.00, 1.18])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.24, 95% CI [-14.73, 8.25], t(2068) = -0.55, p = 0.580; Std. beta = -0.07,
## 95% CI [-0.80, 0.66])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.63, 95% CI [-11.58, 14.85], t(2068) = 0.24, p = 0.809; Std. beta = 0.01,
## 95% CI [-0.91, 0.94])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.41, 95% CI [-24.43, 1.61], t(2068) = -1.72, p = 0.086; Std. beta = -1.10,
## 95% CI [-2.09, -0.11])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.20, 95% CI [-15.98, 3.58], t(2068) = -1.24, p = 0.214; Std. beta = -0.34,
## 95% CI [-1.01, 0.33])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.28, 95% CI [-32.76, -1.79], t(2068) = -2.19, p = 0.029; Std. beta = -0.28,
## 95% CI [-1.38, 0.82])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.91, 95% CI [-7.68, 15.49], t(2068) = 0.66, p = 0.508; Std. beta = 0.76, 95%
## CI [-0.06, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.26, 95% CI [-10.37, 14.89], t(2068) = 0.35, p = 0.726; Std. beta = -0.03,
## 95% CI [-0.86, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -5.50, 95% CI [-14.52, 3.53], t(2068) = -1.19, p = 0.232; Std. beta = -0.55,
## 95% CI [-1.15, 0.05])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.74, 95% CI [-23.25, 28.73], t(2068) = 0.21, p = 0.836; Std. beta = -2.90,
## 95% CI [-5.05, -0.74])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 5.85, 95% CI [-12.39, 24.10], t(2068) = 0.63, p = 0.529; Std. beta = 0.52,
## 95% CI [-0.79, 1.83])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.80, 95% CI [-27.81, 2.22], t(2068) = -1.67, p = 0.095; Std. beta = -0.52,
## 95% CI [-1.88, 0.83])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -8.36, 95% CI [-16.81, 0.08], t(2068) = -1.94, p = 0.052; Std. beta = -0.89,
## 95% CI [-1.97, 0.19])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.79, 95% CI [-1.47, 3.05], t(2068) =
## 0.68, p = 0.495; Std. beta = 0.04, 95% CI [-0.07, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -35.05, 95% CI [-71.43, 1.33], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.34, 95% CI [-8.85, 0.16])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-13.01, 10.31], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.47, 95% CI [-14.82, 9.87], t(2068) = -0.39, p = 0.694; Std.
## beta = -0.31, 95% CI [-1.84, 1.22])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.65, 95% CI [-18.48, 11.17], t(2068) = -0.48, p = 0.629;
## Std. beta = -0.45, 95% CI [-2.29, 1.38])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.24, 95% CI [-6.69, 13.17], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.40, 95% CI [-0.83, 1.63])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.96, 95% CI [-5.74, -0.18], t(2068) = -2.09, p = 0.037; Std.
## beta = -0.37, 95% CI [-0.71, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.27, 9.30], t(2068) = 0.24, p = 0.810; Std.
## beta = 0.13, 95% CI [-0.90, 1.15])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.97, 95% CI [-3.07, 1.13], t(2068) = -0.91, p = 0.365; Std.
## beta = -0.12, 95% CI [-0.38, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.77, 2.83], t(2068) = -0.67, p = 0.504; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-0.73, 4.02], t(2068) = 1.36, p = 0.173; Std.
## beta = 0.20, 95% CI [-0.09, 0.50])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.83, 95% CI [-4.62, 10.28], t(2068) = 0.74, p = 0.457; Std.
## beta = 0.35, 95% CI [-0.57, 1.27])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.04, 95% CI [-2.33, 2.24], t(2068) = -0.04, p = 0.970; Std.
## beta = -5.48e-03, 95% CI [-0.29, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-1.97, 4.35], t(2068) = 0.74, p = 0.459; Std.
## beta = 0.15, 95% CI [-0.24, 0.54])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.30, 95% CI [-29.34, 2.74], t(2068) = -1.63, p = 0.104;
## Std. beta = -1.65, 95% CI [-3.63, 0.34])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.12, 95% CI [-2.70, 10.94], t(2068) = 1.19, p = 0.236; Std.
## beta = 0.51, 95% CI [-0.33, 1.36])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.38, 95% CI [-0.27, 11.02], t(2068) = 1.87, p = 0.062; Std.
## beta = 0.67, 95% CI [-0.03, 1.37])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.34, 95% CI [-6.55, 9.24], t(2068) = 0.33, p = 0.738; Std.
## beta = 0.17, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.27, 7.22], t(2068) = -0.13, p = 0.894; Std.
## beta = -0.07, 95% CI [-1.02, 0.89])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.92, 95% CI [-57.38, 35.54], t(2068) = -0.46, p = 0.645;
## Std. beta = -1.35, 95% CI [-7.11, 4.40])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.63, 95% CI [-29.46, 26.20], t(2068) = -0.11, p = 0.909;
## Std. beta = -0.20, 95% CI [-3.65, 3.25])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.35, 95% CI [-6.51, 3.81], t(2068) = -0.51, p = 0.608; Std.
## beta = -0.17, 95% CI [-0.81, 0.47])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-35.88, 15.08], t(2068) = -0.80, p = 0.424;
## Std. beta = -1.29, 95% CI [-4.44, 1.87])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.93, 95% CI [-6.74, 12.60], t(2068) = 0.59, p = 0.552; Std.
## beta = 0.36, 95% CI [-0.83, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.81, 95% CI [-5.88, 7.49], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.10, 95% CI [-0.73, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.62, 95% CI [-3.80, 15.03], t(2068) = 1.17, p = 0.242; Std.
## beta = 0.70, 95% CI [-0.47, 1.86])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.05, 95% CI [-1.40, 9.49], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.50, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-11.45, 9.86], t(2068) = -0.15, p = 0.884; Std.
## beta = -0.10, 95% CI [-1.42, 1.22])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.79, 95% CI [-8.65, 1.08], t(2068) = -1.53, p = 0.127; Std.
## beta = -0.47, 95% CI [-1.07, 0.13])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.55, 95% CI [-8.37, 3.27], t(2068) = -0.86, p = 0.390; Std.
## beta = -0.32, 95% CI [-1.04, 0.40])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.87, 95% CI [-35.49, 15.75], t(2068) = -0.76, p = 0.450;
## Std. beta = -1.22, 95% CI [-4.40, 1.95])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.89, 95% CI [-12.92, 7.14], t(2068) = -0.56, p = 0.572; Std.
## beta = -0.36, 95% CI [-1.60, 0.88])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.50, 95% CI [-2.57, 5.56], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.19, 95% CI [-0.32, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.94, 95% CI [-7.99, 6.10], t(2068) = -0.26, p = 0.793; Std.
## beta = -0.12, 95% CI [-0.99, 0.76])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-10.66, 4.34], t(2068) = -0.83, p = 0.409; Std.
## beta = -0.39, 95% CI [-1.32, 0.54])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.80, 95% CI [-3.90, 5.50], t(2068) = 0.33, p = 0.740; Std.
## beta = 0.10, 95% CI [-0.48, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.74, 95% CI [-0.42, 17.90], t(2068) = 1.87, p = 0.062; Std.
## beta = 1.08, 95% CI [-0.05, 2.22])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.83, 95% CI [-0.97, 10.63], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.74, 95% CI [-7.35, 3.87], t(2068) = -0.61, p = 0.543; Std.
## beta = -0.22, 95% CI [-0.91, 0.48])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.72, 2.23], t(2068) = -0.86, p = 0.389; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.98, 95% CI [-50.50, -9.45], t(2068) = -2.86, p = 0.004;
## Std. beta = -3.71, 95% CI [-6.26, -1.17])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.19, 95% CI [-7.82, 10.19], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.15, 95% CI [-0.97, 1.26])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.38, 95% CI [-9.69, 16.44], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.42, 95% CI [-1.20, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-14.76, 8.44], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.83, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*NO3_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14884.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1159 -0.4945 -0.0102 0.4397 7.0857
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 136.46 11.681
## time_firstPFT 11.16 3.341 -0.28
## Residual 41.85 6.469
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 43.78395 5.31125 8.244
## time_firstPFT -3.34501 2.52761 -1.323
## NO3_5yrPreCensor -5.58728 2.05500 -2.719
## disadv -5.84805 2.32374 -2.517
## dich_RaceNon-White -2.41577 2.27947 -1.060
## sexF -2.14771 1.41436 -1.519
## age_dx 0.13881 0.07353 1.888
## smokeHxFormer -2.62605 1.40319 -1.871
## smokeHxAlways 9.30599 7.01224 1.327
## smokeHxUnknown -2.57422 3.16338 -0.814
## site02R -4.37574 13.40772 -0.326
## site03R 20.68441 9.83277 2.104
## site04R -1.40251 9.19165 -0.153
## site05R -13.66867 7.66528 -1.783
## site06R -8.89294 13.41436 -0.663
## site07R 4.87711 3.68033 1.325
## site09R -12.34459 9.30751 -1.326
## site101 19.26129 2.54653 7.564
## site102 5.44887 4.99178 1.092
## site103 -5.61361 2.69436 -2.083
## site104 -13.10823 5.42400 -2.417
## site105 -0.06185 2.63794 -0.023
## site106 -5.64868 3.38702 -1.668
## site107 5.82019 9.50247 0.612
## site108 -7.02001 7.90431 -0.888
## site10R -3.71428 13.37775 -0.278
## site11R -5.20950 5.83932 -0.892
## site12R -9.00095 9.20005 -0.978
## site13R -12.98195 7.24825 -1.791
## site14R -9.35844 14.90664 -0.628
## site15R -24.26592 13.55861 -1.790
## site16R -8.13112 5.86930 -1.385
## site17R 62.95399 13.54051 4.649
## site18R -6.43758 9.60355 -0.670
## site19R -11.54627 6.35721 -1.816
## site20R -4.24007 5.50216 -0.771
## site21R -14.86842 12.50008 -1.189
## site22R -12.76521 4.27201 -2.988
## site23R -27.69063 7.69918 -3.597
## site24R 2.57680 4.95066 0.520
## site25R -7.25324 5.54066 -1.309
## site28R -14.94180 7.83210 -1.908
## site29R -5.26993 13.14712 -0.401
## site31R -3.86225 5.88959 -0.656
## site32R 2.07782 6.72251 0.309
## site33R -11.59194 6.59991 -1.756
## site34R -6.14226 4.94714 -1.242
## site35R -17.67040 7.86305 -2.247
## site36R 3.42513 5.87547 0.583
## site37R 0.40830 6.46640 0.063
## site38R -4.57274 4.57232 -1.000
## site39R 10.23010 13.37635 0.765
## site40R 3.99946 9.24713 0.433
## site41R -13.95587 7.64112 -1.826
## site42R -10.37255 4.31929 -2.401
## time_firstPFT:NO3_5yrPreCensor 0.53043 1.19607 0.443
## time_firstPFT:disadv 1.56301 1.10789 1.411
## time_firstPFT:dich_RaceNon-White -0.57572 1.12821 -0.510
## time_firstPFT:sexF 0.69887 0.66008 1.059
## time_firstPFT:age_dx -0.03965 0.03439 -1.153
## time_firstPFT:smokeHxFormer -0.66896 0.67272 -0.994
## time_firstPFT:smokeHxAlways -6.39183 6.04195 -1.058
## time_firstPFT:smokeHxUnknown 2.20576 1.67680 1.315
## time_firstPFT:site02R -33.15204 18.56917 -1.785
## time_firstPFT:site03R -0.82454 5.98390 -0.138
## time_firstPFT:site04R -2.92499 6.33081 -0.462
## time_firstPFT:site05R -3.47848 7.57450 -0.459
## time_firstPFT:site07R -2.22508 1.46986 -1.514
## time_firstPFT:site09R 2.18096 4.24761 0.513
## time_firstPFT:site101 -0.76832 1.08965 -0.705
## time_firstPFT:site102 -0.77773 2.21824 -0.351
## time_firstPFT:site103 1.85697 1.29303 1.436
## time_firstPFT:site104 2.23811 3.86076 0.580
## time_firstPFT:site105 0.03795 1.17410 0.032
## time_firstPFT:site106 1.82385 1.65171 1.104
## time_firstPFT:site107 -12.40683 8.18753 -1.515
## time_firstPFT:site108 4.69683 3.70314 1.268
## time_firstPFT:site11R 5.97621 2.92118 2.046
## time_firstPFT:site12R 1.87685 4.04108 0.464
## time_firstPFT:site13R -0.39044 3.97955 -0.098
## time_firstPFT:site14R -9.63330 23.71035 -0.406
## time_firstPFT:site15R -2.06077 14.20637 -0.145
## time_firstPFT:site16R -1.39322 2.68256 -0.519
## time_firstPFT:site18R -10.34725 13.00797 -0.795
## time_firstPFT:site19R 2.81742 4.99147 0.564
## time_firstPFT:site20R 0.71147 3.44945 0.206
## time_firstPFT:site21R 6.16202 4.79503 1.285
## time_firstPFT:site22R 5.42427 2.82462 1.920
## time_firstPFT:site23R 22.60643 26.70232 0.847
## time_firstPFT:site24R -3.30713 2.49227 -1.327
## time_firstPFT:site25R -1.42892 3.02164 -0.473
## time_firstPFT:site28R -8.95455 13.14384 -0.681
## time_firstPFT:site29R -1.19542 5.14543 -0.232
## time_firstPFT:site31R 2.24134 2.13404 1.050
## time_firstPFT:site32R -0.48016 3.63208 -0.132
## time_firstPFT:site33R -3.67455 3.87489 -0.948
## time_firstPFT:site34R 0.94509 2.43022 0.389
## time_firstPFT:site35R 9.54596 4.71147 2.026
## time_firstPFT:site36R 5.02321 2.97924 1.686
## time_firstPFT:site37R -1.22918 2.95606 -0.416
## time_firstPFT:site38R -1.75054 2.03648 -0.860
## time_firstPFT:site39R -30.20100 10.55355 -2.862
## time_firstPFT:site40R 0.93209 4.64175 0.201
## time_firstPFT:site41R 4.39007 6.68457 0.657
## time_firstPFT:site42R -3.31211 5.93944 -0.558##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.798
## Unadjusted ICC: 0.524report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NO3_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 43.78 (95% CI [33.37, 54.20], t(2038)
## = 8.24, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NO3_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to
## NO3_5yrPreCensor = 0, is at 43.78 (95% CI [33.37, 54.20], t(2038) = 8.24, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to disadv = 0,
## is at 43.78 (95% CI [33.37, 54.20], t(2038) = 8.24, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to dich_Race =
## White, is at 43.78 (95% CI [33.37, 54.20], t(2038) = 8.24, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 43.78 (95% CI [33.37,
## 54.20], t(2038) = 8.24, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to age_dx = 0,
## is at 43.78 (95% CI [33.37, 54.20], t(2038) = 8.24, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to smokeHx =
## Never, is at 43.78 (95% CI [33.37, 54.20], t(2038) = 8.24, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 43.78 (95% CI [33.37,
## 54.20], t(2038) = 8.24, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NO3_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 43.78 (95% CI [33.37, 54.20], t(2038) = 8.24, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.35, 95% CI [-8.30, 1.61], t(2038) = -1.32, p = 0.186; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of NO3 5yrPreCensor is statistically significant and negative
## (beta = -5.59, 95% CI [-9.62, -1.56], t(2038) = -2.72, p = 0.007; Std. beta =
## -0.12, 95% CI [-0.24, -5.44e-03])
## - The effect of disadv is statistically significant and negative (beta = -5.85,
## 95% CI [-10.41, -1.29], t(2038) = -2.52, p = 0.012; Std. beta = -0.07, 95% CI
## [-0.16, 0.02])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-6.89, 2.05], t(2038) = -1.06, p = 0.289; Std.
## beta = -0.22, 95% CI [-0.54, 0.09])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.15, 95% CI [-4.92, 0.63], t(2038) = -1.52, p = 0.129; Std. beta = -0.07, 95%
## CI [-0.27, 0.12])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-5.39e-03, 0.28], t(2038) = 1.89, p = 0.059; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.63, 95% CI [-5.38, 0.13], t(2038) = -1.87, p = 0.061; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.31, 95% CI [-4.45, 23.06], t(2038) = 1.33, p = 0.185; Std. beta =
## -0.03, 95% CI [-1.28, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.57, 95% CI [-8.78, 3.63], t(2038) = -0.81, p = 0.416; Std. beta =
## 0.05, 95% CI [-0.41, 0.51])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -4.38, 95% CI [-30.67, 21.92], t(2038) = -0.33, p = 0.744; Std. beta = -3.72,
## 95% CI [-7.13, -0.31])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.68, 95% CI [1.40, 39.97], t(2038) = 2.10, p = 0.036; Std. beta = 1.32, 95%
## CI [0.05, 2.59])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-19.43, 16.62], t(2038) = -0.15, p = 0.879; Std. beta = -0.40,
## 95% CI [-1.85, 1.05])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.67, 95% CI [-28.70, 1.36], t(2038) = -1.78, p = 0.075; Std. beta = -1.29,
## 95% CI [-2.78, 0.20])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.89, 95% CI [-35.20, 17.41], t(2038) = -0.66, p = 0.507; Std. beta = -0.60,
## 95% CI [-2.39, 1.18])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-2.34, 12.09], t(2038) = 1.33, p = 0.185; Std. beta = 0.10, 95%
## CI [-0.37, 0.58])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.34, 95% CI [-30.60, 5.91], t(2038) = -1.33, p = 0.185; Std. beta = -0.61,
## 95% CI [-1.88, 0.65])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.26, 95% CI [14.27, 24.26], t(2038) = 7.56, p < .001; Std. beta = 1.23, 95%
## CI [0.89, 1.57])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 5.45, 95% CI [-4.34, 15.24], t(2038) = 1.09, p = 0.275; Std. beta = 0.29, 95%
## CI [-0.36, 0.94])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.61, 95% CI [-10.90, -0.33], t(2038) = -2.08, p = 0.037; Std. beta = -0.19,
## 95% CI [-0.56, 0.18])
## - The effect of site [104] is statistically significant and negative (beta =
## -13.11, 95% CI [-23.75, -2.47], t(2038) = -2.42, p = 0.016; Std. beta = -0.66,
## 95% CI [-1.56, 0.24])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.06, 95% CI [-5.24, 5.11], t(2038) = -0.02, p = 0.981; Std. beta =
## -2.88e-04, 95% CI [-0.35, 0.35])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-12.29, 0.99], t(2038) = -1.67, p = 0.096; Std. beta = -0.20,
## 95% CI [-0.64, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.82, 95% CI [-12.82, 24.46], t(2038) = 0.61, p = 0.540; Std. beta = -0.88,
## 95% CI [-2.51, 0.74])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.02, 95% CI [-22.52, 8.48], t(2038) = -0.89, p = 0.375; Std. beta =
## 7.38e-03, 95% CI [-1.03, 1.04])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -3.71, 95% CI [-29.95, 22.52], t(2038) = -0.28, p = 0.781; Std. beta = -0.25,
## 95% CI [-2.04, 1.53])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -5.21, 95% CI [-16.66, 6.24], t(2038) = -0.89, p = 0.372; Std. beta = 0.26,
## 95% CI [-0.56, 1.08])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.00, 95% CI [-27.04, 9.04], t(2038) = -0.98, p = 0.328; Std. beta = -0.42,
## 95% CI [-1.68, 0.84])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.98, 95% CI [-27.20, 1.23], t(2038) = -1.79, p = 0.073; Std. beta = -0.92,
## 95% CI [-1.88, 0.04])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.36, 95% CI [-38.59, 19.88], t(2038) = -0.63, p = 0.530; Std. beta = -1.63,
## 95% CI [-5.06, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.27, 95% CI [-50.86, 2.32], t(2038) = -1.79, p = 0.074; Std. beta = -1.86,
## 95% CI [-4.50, 0.78])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.13, 95% CI [-19.64, 3.38], t(2038) = -1.39, p = 0.166; Std. beta = -0.70,
## 95% CI [-1.51, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.95, 95% CI [36.40, 89.51], t(2038) = 4.65, p < .001; Std. beta = 4.28, 95%
## CI [2.47, 6.08])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.44, 95% CI [-25.27, 12.40], t(2038) = -0.67, p = 0.503; Std. beta = -1.50,
## 95% CI [-4.03, 1.03])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.55, 95% CI [-24.01, 0.92], t(2038) = -1.82, p = 0.069; Std. beta = -0.49,
## 95% CI [-1.58, 0.59])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -4.24, 95% CI [-15.03, 6.55], t(2038) = -0.77, p = 0.441; Std. beta = -0.21,
## 95% CI [-1.03, 0.60])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -14.87, 95% CI [-39.38, 9.65], t(2038) = -1.19, p = 0.234; Std. beta = -0.37,
## 95% CI [-1.95, 1.20])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.77, 95% CI [-21.14, -4.39], t(2038) = -2.99, p = 0.003; Std. beta = -0.31,
## 95% CI [-0.95, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.69, 95% CI [-42.79, -12.59], t(2038) = -3.60, p < .001; Std. beta = 0.45,
## 95% CI [-4.53, 5.43])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-7.13, 12.29], t(2038) = 0.52, p = 0.603; Std. beta = -0.17,
## 95% CI [-0.83, 0.50])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -7.25, 95% CI [-18.12, 3.61], t(2038) = -1.31, p = 0.191; Std. beta = -0.64,
## 95% CI [-1.40, 0.12])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -14.94, 95% CI [-30.30, 0.42], t(2038) = -1.91, p = 0.057; Std. beta = -1.94,
## 95% CI [-4.53, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.27, 95% CI [-31.05, 20.51], t(2038) = -0.40, p = 0.689; Std. beta = -0.48,
## 95% CI [-2.08, 1.12])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -3.86, 95% CI [-15.41, 7.69], t(2038) = -0.66, p = 0.512; Std. beta = -0.03,
## 95% CI [-0.77, 0.71])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.08, 95% CI [-11.11, 15.26], t(2038) = 0.31, p = 0.757; Std. beta = 0.09,
## 95% CI [-0.85, 1.03])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.59, 95% CI [-24.54, 1.35], t(2038) = -1.76, p = 0.079; Std. beta = -1.17,
## 95% CI [-2.17, -0.16])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.14, 95% CI [-15.84, 3.56], t(2038) = -1.24, p = 0.215; Std. beta = -0.32,
## 95% CI [-0.99, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.67, 95% CI [-33.09, -2.25], t(2038) = -2.25, p = 0.025; Std. beta = -0.22,
## 95% CI [-1.33, 0.89])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.43, 95% CI [-8.10, 14.95], t(2038) = 0.58, p = 0.560; Std. beta = 0.75, 95%
## CI [-0.08, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.41, 95% CI [-12.27, 13.09], t(2038) = 0.06, p = 0.950; Std. beta = -0.10,
## 95% CI [-0.95, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -4.57, 95% CI [-13.54, 4.39], t(2038) = -1.00, p = 0.317; Std. beta = -0.49,
## 95% CI [-1.09, 0.11])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.23, 95% CI [-16.00, 36.46], t(2038) = 0.76, p = 0.444; Std. beta = -2.42,
## 95% CI [-4.61, -0.23])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 4.00, 95% CI [-14.14, 22.13], t(2038) = 0.43, p = 0.665; Std. beta = 0.37,
## 95% CI [-0.95, 1.69])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.96, 95% CI [-28.94, 1.03], t(2038) = -1.83, p = 0.068; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.37, 95% CI [-18.84, -1.90], t(2038) = -2.40, p = 0.016; Std. beta = -1.05,
## 95% CI [-2.14, 0.05])
## - The effect of time firstPFT × NO3 5yrPreCensor is statistically
## non-significant and positive (beta = 0.53, 95% CI [-1.82, 2.88], t(2038) =
## 0.44, p = 0.657; Std. beta = 0.03, 95% CI [-0.09, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.56, 95% CI [-0.61, 3.74], t(2038) = 1.41, p = 0.158; Std.
## beta = 0.06, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.79, 1.64], t(2038) =
## -0.51, p = 0.610; Std. beta = -0.07, 95% CI [-0.35, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.70, 95% CI [-0.60, 1.99], t(2038) = 1.06, p = 0.290; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.249; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.67, 95% CI [-1.99, 0.65], t(2038) =
## -0.99, p = 0.320; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.39, 95% CI [-18.24, 5.46], t(2038) =
## -1.06, p = 0.290; Std. beta = -0.79, 95% CI [-2.26, 0.68])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.21, 95% CI [-1.08, 5.49], t(2038) =
## 1.32, p = 0.189; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.15, 95% CI [-69.57, 3.26], t(2038) = -1.79, p = 0.074;
## Std. beta = -4.11, 95% CI [-8.63, 0.41])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.82, 95% CI [-12.56, 10.91], t(2038) = -0.14, p = 0.890;
## Std. beta = -0.10, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-15.34, 9.49], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.36, 95% CI [-1.90, 1.18])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-18.33, 11.38], t(2038) = -0.46, p = 0.646;
## Std. beta = -0.43, 95% CI [-2.27, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.23, 95% CI [-5.11, 0.66], t(2038) = -1.51, p = 0.130; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.18, 95% CI [-6.15, 10.51], t(2038) = 0.51, p = 0.608; Std.
## beta = 0.27, 95% CI [-0.76, 1.30])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.77, 95% CI [-2.91, 1.37], t(2038) = -0.71, p = 0.481; Std.
## beta = -0.10, 95% CI [-0.36, 0.17])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.78, 95% CI [-5.13, 3.57], t(2038) = -0.35, p = 0.726; Std.
## beta = -0.10, 95% CI [-0.64, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-0.68, 4.39], t(2038) = 1.44, p = 0.151; Std.
## beta = 0.23, 95% CI [-0.08, 0.55])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-5.33, 9.81], t(2038) = 0.58, p = 0.562; Std.
## beta = 0.28, 95% CI [-0.66, 1.22])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.04, 95% CI [-2.26, 2.34], t(2038) = 0.03, p = 0.974; Std.
## beta = 4.71e-03, 95% CI [-0.28, 0.29])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.42, 5.06], t(2038) = 1.10, p = 0.270; Std.
## beta = 0.23, 95% CI [-0.18, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.41, 95% CI [-28.46, 3.65], t(2038) = -1.52, p = 0.130;
## Std. beta = -1.54, 95% CI [-3.53, 0.45])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.57, 11.96], t(2038) = 1.27, p = 0.205; Std.
## beta = 0.58, 95% CI [-0.32, 1.48])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.98, 95% CI [0.25, 11.71], t(2038) = 2.05, p = 0.041; Std.
## beta = 0.74, 95% CI [0.03, 1.45])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-6.05, 9.80], t(2038) = 0.46, p = 0.642; Std.
## beta = 0.23, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.39, 95% CI [-8.19, 7.41], t(2038) = -0.10, p = 0.922; Std.
## beta = -0.05, 95% CI [-1.02, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.63, 95% CI [-56.13, 36.87], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.20, 95% CI [-6.96, 4.57])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-29.92, 25.80], t(2038) = -0.15, p = 0.885;
## Std. beta = -0.26, 95% CI [-3.71, 3.20])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.39, 95% CI [-6.65, 3.87], t(2038) = -0.52, p = 0.604; Std.
## beta = -0.17, 95% CI [-0.83, 0.48])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.35, 95% CI [-35.86, 15.16], t(2038) = -0.80, p = 0.426;
## Std. beta = -1.28, 95% CI [-4.45, 1.88])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.82, 95% CI [-6.97, 12.61], t(2038) = 0.56, p = 0.573; Std.
## beta = 0.35, 95% CI [-0.86, 1.56])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-6.05, 7.48], t(2038) = 0.21, p = 0.837; Std.
## beta = 0.09, 95% CI [-0.75, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.16, 95% CI [-3.24, 15.57], t(2038) = 1.29, p = 0.199; Std.
## beta = 0.76, 95% CI [-0.40, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.12, 10.96], t(2038) = 1.92, p = 0.055; Std.
## beta = 0.67, 95% CI [-0.01, 1.36])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.61, 95% CI [-29.76, 74.97], t(2038) = 0.85, p = 0.397; Std.
## beta = 2.80, 95% CI [-3.69, 9.30])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-8.19, 1.58], t(2038) = -1.33, p = 0.185; Std.
## beta = -0.41, 95% CI [-1.02, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-7.35, 4.50], t(2038) = -0.47, p = 0.636; Std.
## beta = -0.18, 95% CI [-0.91, 0.56])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.95, 95% CI [-34.73, 16.82], t(2038) = -0.68, p = 0.496;
## Std. beta = -1.11, 95% CI [-4.31, 2.09])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.20, 95% CI [-11.29, 8.90], t(2038) = -0.23, p = 0.816; Std.
## beta = -0.15, 95% CI [-1.40, 1.10])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.24, 95% CI [-1.94, 6.43], t(2038) = 1.05, p = 0.294; Std.
## beta = 0.28, 95% CI [-0.24, 0.80])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.48, 95% CI [-7.60, 6.64], t(2038) = -0.13, p = 0.895; Std.
## beta = -0.06, 95% CI [-0.94, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.67, 95% CI [-11.27, 3.92], t(2038) = -0.95, p = 0.343; Std.
## beta = -0.46, 95% CI [-1.40, 0.49])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-3.82, 5.71], t(2038) = 0.39, p = 0.697; Std.
## beta = 0.12, 95% CI [-0.47, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.55, 95% CI [0.31, 18.79], t(2038) = 2.03, p = 0.043; Std.
## beta = 1.18, 95% CI [0.04, 2.33])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.82, 10.87], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.23, 95% CI [-7.03, 4.57], t(2038) = -0.42, p = 0.678; Std.
## beta = -0.15, 95% CI [-0.87, 0.57])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-5.74, 2.24], t(2038) = -0.86, p = 0.390; Std.
## beta = -0.22, 95% CI [-0.71, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.90, -9.50], t(2038) = -2.86, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.18])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-8.17, 10.04], t(2038) = 0.20, p = 0.841; Std.
## beta = 0.12, 95% CI [-1.01, 1.25])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.72, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.54, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.31, 95% CI [-14.96, 8.34], t(2038) = -0.56, p = 0.577; Std.
## beta = -0.41, 95% CI [-1.86, 1.03])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*NH4_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15057.9
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1346 -0.4883 -0.0041 0.4378 7.1103
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 141.61 11.900
## time_firstPFT 11.42 3.379 -0.32
## Residual 41.80 6.465
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 47.6138 2.7666 17.210
## time_firstPFT -4.6244 1.2185 -3.795
## NH4_5yrPreCensor -5.3109 1.8731 -2.835
## site02R -7.6674 13.6784 -0.561
## site03R 19.7043 10.0639 1.958
## site04R -9.2314 9.3317 -0.989
## site05R -16.6385 7.8669 -2.115
## site06R 0.6975 9.7497 0.072
## site07R 1.2630 3.9975 0.316
## site09R -13.5279 9.5575 -1.415
## site101 15.4317 3.0538 5.053
## site102 3.0177 5.3692 0.562
## site103 -8.1957 3.1706 -2.585
## site104 -15.8756 5.6626 -2.804
## site105 -3.5598 3.1474 -1.131
## site106 -7.6328 3.6755 -2.077
## site107 5.3575 9.7446 0.550
## site108 -14.1044 7.8235 -1.803
## site10R -7.4965 13.4463 -0.558
## site11R -6.0417 6.0857 -0.993
## site12R -14.5016 9.5271 -1.522
## site13R -14.5543 7.4818 -1.945
## site14R -11.2969 15.0584 -0.750
## site15R -29.2226 13.7468 -2.126
## site16R -12.9935 6.1139 -2.125
## site17R 54.9531 13.6849 4.016
## site18R -10.3351 9.8228 -1.052
## site19R -11.7562 6.5422 -1.797
## site20R -7.6827 5.8261 -1.319
## site21R -18.2915 12.8201 -1.427
## site22R -14.9747 4.4847 -3.339
## site23R -23.5940 6.3639 -3.707
## site24R -2.4431 5.3161 -0.460
## site25R -10.9140 5.8301 -1.872
## site28R -20.8224 7.9959 -2.604
## site29R -5.1426 13.4194 -0.383
## site31R -5.3046 6.1015 -0.869
## site32R -0.6279 6.9926 -0.090
## site33R -13.0829 6.8006 -1.924
## site34R -9.2971 5.2625 -1.767
## site35R -19.2102 8.0996 -2.372
## site36R -0.4008 6.1156 -0.066
## site37R -2.5158 6.6759 -0.377
## site38R -7.1112 4.8658 -1.461
## site39R 0.9041 13.3849 0.068
## site40R -1.9066 9.3450 -0.204
## site41R -18.2481 7.8953 -2.311
## site42R -12.6182 4.5732 -2.759
## time_firstPFT:NH4_5yrPreCensor 0.2524 0.8631 0.292
## time_firstPFT:site02R -34.5550 18.5682 -1.861
## time_firstPFT:site03R -1.1032 6.0172 -0.183
## time_firstPFT:site04R -1.7774 6.3019 -0.282
## time_firstPFT:site05R -3.5480 7.5863 -0.468
## time_firstPFT:site06R 3.2710 5.1025 0.641
## time_firstPFT:site07R -2.6168 1.5819 -1.654
## time_firstPFT:site09R 1.0229 4.3109 0.237
## time_firstPFT:site101 -0.8506 1.2938 -0.657
## time_firstPFT:site102 -1.4327 2.3601 -0.607
## time_firstPFT:site103 1.4428 1.3872 1.040
## time_firstPFT:site104 2.4450 3.8686 0.632
## time_firstPFT:site105 -0.1066 1.3585 -0.078
## time_firstPFT:site106 1.3610 1.7460 0.780
## time_firstPFT:site107 -13.4017 8.2101 -1.632
## time_firstPFT:site108 3.8621 3.5411 1.091
## time_firstPFT:site11R 5.1103 2.9343 1.742
## time_firstPFT:site12R 1.4049 4.1322 0.340
## time_firstPFT:site13R -0.5176 4.0291 -0.128
## time_firstPFT:site14R -10.8324 23.6974 -0.457
## time_firstPFT:site15R -1.9328 14.1966 -0.136
## time_firstPFT:site16R -1.1843 2.7683 -0.428
## time_firstPFT:site18R -10.6891 13.0050 -0.822
## time_firstPFT:site19R 2.5047 4.9416 0.507
## time_firstPFT:site20R 0.9038 3.4987 0.258
## time_firstPFT:site21R 5.5304 4.8652 1.137
## time_firstPFT:site22R 4.2912 2.8740 1.493
## time_firstPFT:site23R -0.9297 5.4382 -0.171
## time_firstPFT:site24R -3.4789 2.6113 -1.332
## time_firstPFT:site25R -2.1142 3.0854 -0.685
## time_firstPFT:site28R -9.5943 13.0771 -0.734
## time_firstPFT:site29R -2.9166 5.1900 -0.562
## time_firstPFT:site31R 1.3181 2.1623 0.610
## time_firstPFT:site32R -1.1456 3.6829 -0.311
## time_firstPFT:site33R -3.3441 3.8536 -0.868
## time_firstPFT:site34R 0.7934 2.5123 0.316
## time_firstPFT:site35R 8.4551 4.7128 1.794
## time_firstPFT:site36R 5.0342 3.0356 1.658
## time_firstPFT:site37R -1.4772 2.9518 -0.500
## time_firstPFT:site38R -1.9713 2.1021 -0.938
## time_firstPFT:site39R -30.2030 10.4835 -2.881
## time_firstPFT:site40R 1.8784 4.6468 0.404
## time_firstPFT:site41R 3.6493 6.7109 0.544
## time_firstPFT:site42R -2.9338 5.9523 -0.493##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.799
## Unadjusted ICC: 0.535report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NH4_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.33. The model's
## intercept, corresponding to time_firstPFT = 0, is at 47.61 (95% CI [42.19,
## 53.04], t(2068) = 17.21, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.62, 95% CI [-7.01, -2.23], t(2068) = -3.80, p < .001; Std. beta = -0.55, 95%
## CI [-0.72, -0.38])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.31, 95% CI [-8.98, -1.64], t(2068) = -2.84, p = 0.005; Std. beta =
## -0.20, 95% CI [-0.35, -0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.67, 95% CI [-34.49, 19.16], t(2068) = -0.56, p = 0.575; Std. beta = -4.07,
## 95% CI [-7.48, -0.67])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 19.70, 95% CI [-0.03, 39.44], t(2068) = 1.96, p = 0.050; Std. beta = 1.23,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-27.53, 9.07], t(2068) = -0.99, p = 0.323; Std. beta = -0.81,
## 95% CI [-2.25, 0.63])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.64, 95% CI [-32.07, -1.21], t(2068) = -2.12, p = 0.035; Std. beta = -1.50,
## 95% CI [-2.99, -1.56e-03])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 0.70, 95% CI [-18.42, 19.82], t(2068) = 0.07, p = 0.943; Std. beta = 0.38,
## 95% CI [-0.99, 1.75])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-6.58, 9.10], t(2068) = 0.32, p = 0.752; Std. beta = -0.18, 95%
## CI [-0.69, 0.32])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.53, 95% CI [-32.27, 5.22], t(2068) = -1.42, p = 0.157; Std. beta = -0.81,
## 95% CI [-2.10, 0.47])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.43, 95% CI [9.44, 21.42], t(2068) = 5.05, p < .001; Std. beta = 0.96, 95% CI
## [0.56, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-7.51, 13.55], t(2068) = 0.56, p = 0.574; Std. beta = 0.06, 95%
## CI [-0.64, 0.75])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.20, 95% CI [-14.41, -1.98], t(2068) = -2.58, p = 0.010; Std. beta = -0.41,
## 95% CI [-0.83, 0.01])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.88, 95% CI [-26.98, -4.77], t(2068) = -2.80, p = 0.005; Std. beta = -0.83,
## 95% CI [-1.74, 0.08])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.56, 95% CI [-9.73, 2.61], t(2068) = -1.13, p = 0.258; Std. beta = -0.25,
## 95% CI [-0.67, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.63, 95% CI [-14.84, -0.42], t(2068) = -2.08, p = 0.038; Std. beta = -0.38,
## 95% CI [-0.86, 0.10])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-13.75, 24.47], t(2068) = 0.55, p = 0.583; Std. beta = -1.01,
## 95% CI [-2.65, 0.62])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -14.10, 95% CI [-29.45, 1.24], t(2068) = -1.80, p = 0.072; Std. beta = -0.56,
## 95% CI [-1.56, 0.44])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.50, 95% CI [-33.87, 18.87], t(2068) = -0.56, p = 0.577; Std. beta = -0.51,
## 95% CI [-2.30, 1.28])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-17.98, 5.89], t(2068) = -0.99, p = 0.321; Std. beta = 0.11,
## 95% CI [-0.72, 0.95])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -14.50, 95% CI [-33.19, 4.18], t(2068) = -1.52, p = 0.128; Std. beta = -0.84,
## 95% CI [-2.13, 0.44])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.55, 95% CI [-29.23, 0.12], t(2068) = -1.95, p = 0.052; Std. beta = -1.04,
## 95% CI [-2.02, -0.07])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -11.30, 95% CI [-40.83, 18.23], t(2068) = -0.75, p = 0.453; Std. beta =
## -1.88, 95% CI [-5.30, 1.54])
## - The effect of site [15R] is statistically significant and negative (beta =
## -29.22, 95% CI [-56.18, -2.26], t(2068) = -2.13, p = 0.034; Std. beta = -2.19,
## 95% CI [-4.82, 0.44])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.99, 95% CI [-24.98, -1.00], t(2068) = -2.13, p = 0.034; Std. beta = -1.01,
## 95% CI [-1.84, -0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 54.95, 95% CI [28.12, 81.79], t(2068) = 4.02, p < .001; Std. beta = 3.74, 95%
## CI [1.91, 5.56])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.34, 95% CI [-29.60, 8.93], t(2068) = -1.05, p = 0.293; Std. beta = -1.80,
## 95% CI [-4.33, 0.72])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.76, 95% CI [-24.59, 1.07], t(2068) = -1.80, p = 0.072; Std. beta = -0.54,
## 95% CI [-1.62, 0.54])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-19.11, 3.74], t(2068) = -1.32, p = 0.187; Std. beta = -0.43,
## 95% CI [-1.27, 0.41])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.29, 95% CI [-43.43, 6.85], t(2068) = -1.43, p = 0.154; Std. beta = -0.68,
## 95% CI [-2.26, 0.91])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.97, 95% CI [-23.77, -6.18], t(2068) = -3.34, p < .001; Std. beta = -0.58,
## 95% CI [-1.24, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.59, 95% CI [-36.07, -11.11], t(2068) = -3.71, p < .001; Std. beta = -1.70,
## 95% CI [-2.88, -0.52])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-12.87, 7.98], t(2068) = -0.46, p = 0.646; Std. beta = -0.52,
## 95% CI [-1.23, 0.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-22.35, 0.52], t(2068) = -1.87, p = 0.061; Std. beta = -0.96,
## 95% CI [-1.74, -0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -20.82, 95% CI [-36.50, -5.14], t(2068) = -2.60, p = 0.009; Std. beta = -2.40,
## 95% CI [-4.97, 0.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-31.46, 21.17], t(2068) = -0.38, p = 0.702; Std. beta = -0.65,
## 95% CI [-2.26, 0.96])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -5.30, 95% CI [-17.27, 6.66], t(2068) = -0.87, p = 0.385; Std. beta = -0.23,
## 95% CI [-0.98, 0.53])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-14.34, 13.09], t(2068) = -0.09, p = 0.928; Std. beta = -0.16,
## 95% CI [-1.12, 0.80])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-26.42, 0.25], t(2068) = -1.92, p = 0.055; Std. beta = -1.23,
## 95% CI [-2.24, -0.23])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-19.62, 1.02], t(2068) = -1.77, p = 0.077; Std. beta = -0.55,
## 95% CI [-1.25, 0.15])
## - The effect of site [35R] is statistically significant and negative (beta =
## -19.21, 95% CI [-35.09, -3.33], t(2068) = -2.37, p = 0.018; Std. beta = -0.44,
## 95% CI [-1.56, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.40, 95% CI [-12.39, 11.59], t(2068) = -0.07, p = 0.948; Std. beta = 0.49,
## 95% CI [-0.36, 1.34])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -2.52, 95% CI [-15.61, 10.58], t(2068) = -0.38, p = 0.706; Std. beta = -0.32,
## 95% CI [-1.19, 0.54])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.11, 95% CI [-16.65, 2.43], t(2068) = -1.46, p = 0.144; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-25.35, 27.15], t(2068) = 0.07, p = 0.946; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.23, 16.42], t(2068) = -0.20, p = 0.838; Std. beta = 0.06,
## 95% CI [-1.25, 1.38])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.25, 95% CI [-33.73, -2.76], t(2068) = -2.31, p = 0.021; Std. beta = -0.87,
## 95% CI [-2.24, 0.51])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.62, 95% CI [-21.59, -3.65], t(2068) = -2.76, p = 0.006; Std. beta = -1.16,
## 95% CI [-2.26, -0.06])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.25, 95% CI [-1.44, 1.95], t(2068) =
## 0.29, p = 0.770; Std. beta = 0.02, 95% CI [-0.11, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.55, 95% CI [-70.97, 1.86], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.28, 95% CI [-8.79, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-12.90, 10.70], t(2068) = -0.18, p = 0.855;
## Std. beta = -0.14, 95% CI [-1.60, 1.33])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-14.14, 10.58], t(2068) = -0.28, p = 0.778;
## Std. beta = -0.22, 95% CI [-1.75, 1.31])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.43, 11.33], t(2068) = -0.47, p = 0.640;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.27, 95% CI [-6.74, 13.28], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.41, 95% CI [-0.83, 1.64])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-5.72, 0.49], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.43, 9.48], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.13, 95% CI [-0.92, 1.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.39, 1.69], t(2068) = -0.66, p = 0.511; Std.
## beta = -0.11, 95% CI [-0.42, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-6.06, 3.20], t(2068) = -0.61, p = 0.544; Std.
## beta = -0.18, 95% CI [-0.75, 0.40])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-1.28, 4.16], t(2068) = 1.04, p = 0.298; Std.
## beta = 0.18, 95% CI [-0.16, 0.52])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.44, 95% CI [-5.14, 10.03], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.30, 95% CI [-0.64, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-2.77, 2.56], t(2068) = -0.08, p = 0.937; Std.
## beta = -0.01, 95% CI [-0.34, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-2.06, 4.79], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.17, 95% CI [-0.26, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.40, 95% CI [-29.50, 2.70], t(2068) = -1.63, p = 0.103;
## Std. beta = -1.66, 95% CI [-3.65, 0.33])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-3.08, 10.81], t(2068) = 1.09, p = 0.276; Std.
## beta = 0.48, 95% CI [-0.38, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-0.64, 10.86], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.63, 95% CI [-0.08, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-6.70, 9.51], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.17, 95% CI [-0.83, 1.18])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-8.42, 7.38], t(2068) = -0.13, p = 0.898; Std.
## beta = -0.06, 95% CI [-1.04, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-57.31, 35.64], t(2068) = -0.46, p = 0.648;
## Std. beta = -1.34, 95% CI [-7.10, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-29.77, 25.91], t(2068) = -0.14, p = 0.892;
## Std. beta = -0.24, 95% CI [-3.69, 3.21])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-6.61, 4.24], t(2068) = -0.43, p = 0.669; Std.
## beta = -0.15, 95% CI [-0.82, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.19, 14.82], t(2068) = -0.82, p = 0.411;
## Std. beta = -1.32, 95% CI [-4.48, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-7.19, 12.20], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.31, 95% CI [-0.89, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.96, 7.77], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.53, 95% CI [-4.01, 15.07], t(2068) = 1.14, p = 0.256; Std.
## beta = 0.69, 95% CI [-0.50, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-1.35, 9.93], t(2068) = 1.49, p = 0.136; Std.
## beta = 0.53, 95% CI [-0.17, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-11.59, 9.74], t(2068) = -0.17, p = 0.864; Std.
## beta = -0.12, 95% CI [-1.44, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-8.60, 1.64], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.43, 95% CI [-1.07, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-8.17, 3.94], t(2068) = -0.69, p = 0.493; Std.
## beta = -0.26, 95% CI [-1.01, 0.49])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.59, 95% CI [-35.24, 16.05], t(2068) = -0.73, p = 0.463;
## Std. beta = -1.19, 95% CI [-4.37, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-13.09, 7.26], t(2068) = -0.56, p = 0.574; Std.
## beta = -0.36, 95% CI [-1.62, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-2.92, 5.56], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-8.37, 6.08], t(2068) = -0.31, p = 0.756; Std.
## beta = -0.14, 95% CI [-1.04, 0.75])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-10.90, 4.21], t(2068) = -0.87, p = 0.386; Std.
## beta = -0.41, 95% CI [-1.35, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.79, 95% CI [-4.13, 5.72], t(2068) = 0.32, p = 0.752; Std.
## beta = 0.10, 95% CI [-0.51, 0.71])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.46, 95% CI [-0.79, 17.70], t(2068) = 1.79, p = 0.073; Std.
## beta = 1.05, 95% CI [-0.10, 2.19])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-0.92, 10.99], t(2068) = 1.66, p = 0.097; Std.
## beta = 0.62, 95% CI [-0.11, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.27, 4.31], t(2068) = -0.50, p = 0.617; Std.
## beta = -0.18, 95% CI [-0.90, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-6.09, 2.15], t(2068) = -0.94, p = 0.348; Std.
## beta = -0.24, 95% CI [-0.75, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.76, -9.64], t(2068) = -2.88, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.29, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-7.23, 10.99], t(2068) = 0.40, p = 0.686; Std.
## beta = 0.23, 95% CI [-0.90, 1.36])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-9.51, 16.81], t(2068) = 0.54, p = 0.587; Std.
## beta = 0.45, 95% CI [-1.18, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-14.61, 8.74], t(2068) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NH4_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to NH4_5yrPreCensor = 0, is at 47.61 (95% CI [42.19, 53.04],
## t(2068) = 17.21, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.62, 95% CI [-7.01, -2.23], t(2068) = -3.80, p < .001; Std. beta = -0.55, 95%
## CI [-0.72, -0.38])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.31, 95% CI [-8.98, -1.64], t(2068) = -2.84, p = 0.005; Std. beta =
## -0.20, 95% CI [-0.35, -0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.67, 95% CI [-34.49, 19.16], t(2068) = -0.56, p = 0.575; Std. beta = -4.07,
## 95% CI [-7.48, -0.67])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 19.70, 95% CI [-0.03, 39.44], t(2068) = 1.96, p = 0.050; Std. beta = 1.23,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-27.53, 9.07], t(2068) = -0.99, p = 0.323; Std. beta = -0.81,
## 95% CI [-2.25, 0.63])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.64, 95% CI [-32.07, -1.21], t(2068) = -2.12, p = 0.035; Std. beta = -1.50,
## 95% CI [-2.99, -1.56e-03])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 0.70, 95% CI [-18.42, 19.82], t(2068) = 0.07, p = 0.943; Std. beta = 0.38,
## 95% CI [-0.99, 1.75])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-6.58, 9.10], t(2068) = 0.32, p = 0.752; Std. beta = -0.18, 95%
## CI [-0.69, 0.32])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.53, 95% CI [-32.27, 5.22], t(2068) = -1.42, p = 0.157; Std. beta = -0.81,
## 95% CI [-2.10, 0.47])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.43, 95% CI [9.44, 21.42], t(2068) = 5.05, p < .001; Std. beta = 0.96, 95% CI
## [0.56, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-7.51, 13.55], t(2068) = 0.56, p = 0.574; Std. beta = 0.06, 95%
## CI [-0.64, 0.75])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.20, 95% CI [-14.41, -1.98], t(2068) = -2.58, p = 0.010; Std. beta = -0.41,
## 95% CI [-0.83, 0.01])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.88, 95% CI [-26.98, -4.77], t(2068) = -2.80, p = 0.005; Std. beta = -0.83,
## 95% CI [-1.74, 0.08])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.56, 95% CI [-9.73, 2.61], t(2068) = -1.13, p = 0.258; Std. beta = -0.25,
## 95% CI [-0.67, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.63, 95% CI [-14.84, -0.42], t(2068) = -2.08, p = 0.038; Std. beta = -0.38,
## 95% CI [-0.86, 0.10])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-13.75, 24.47], t(2068) = 0.55, p = 0.583; Std. beta = -1.01,
## 95% CI [-2.65, 0.62])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -14.10, 95% CI [-29.45, 1.24], t(2068) = -1.80, p = 0.072; Std. beta = -0.56,
## 95% CI [-1.56, 0.44])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.50, 95% CI [-33.87, 18.87], t(2068) = -0.56, p = 0.577; Std. beta = -0.51,
## 95% CI [-2.30, 1.28])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-17.98, 5.89], t(2068) = -0.99, p = 0.321; Std. beta = 0.11,
## 95% CI [-0.72, 0.95])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -14.50, 95% CI [-33.19, 4.18], t(2068) = -1.52, p = 0.128; Std. beta = -0.84,
## 95% CI [-2.13, 0.44])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.55, 95% CI [-29.23, 0.12], t(2068) = -1.95, p = 0.052; Std. beta = -1.04,
## 95% CI [-2.02, -0.07])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -11.30, 95% CI [-40.83, 18.23], t(2068) = -0.75, p = 0.453; Std. beta =
## -1.88, 95% CI [-5.30, 1.54])
## - The effect of site [15R] is statistically significant and negative (beta =
## -29.22, 95% CI [-56.18, -2.26], t(2068) = -2.13, p = 0.034; Std. beta = -2.19,
## 95% CI [-4.82, 0.44])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.99, 95% CI [-24.98, -1.00], t(2068) = -2.13, p = 0.034; Std. beta = -1.01,
## 95% CI [-1.84, -0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 54.95, 95% CI [28.12, 81.79], t(2068) = 4.02, p < .001; Std. beta = 3.74, 95%
## CI [1.91, 5.56])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.34, 95% CI [-29.60, 8.93], t(2068) = -1.05, p = 0.293; Std. beta = -1.80,
## 95% CI [-4.33, 0.72])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.76, 95% CI [-24.59, 1.07], t(2068) = -1.80, p = 0.072; Std. beta = -0.54,
## 95% CI [-1.62, 0.54])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-19.11, 3.74], t(2068) = -1.32, p = 0.187; Std. beta = -0.43,
## 95% CI [-1.27, 0.41])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.29, 95% CI [-43.43, 6.85], t(2068) = -1.43, p = 0.154; Std. beta = -0.68,
## 95% CI [-2.26, 0.91])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.97, 95% CI [-23.77, -6.18], t(2068) = -3.34, p < .001; Std. beta = -0.58,
## 95% CI [-1.24, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.59, 95% CI [-36.07, -11.11], t(2068) = -3.71, p < .001; Std. beta = -1.70,
## 95% CI [-2.88, -0.52])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-12.87, 7.98], t(2068) = -0.46, p = 0.646; Std. beta = -0.52,
## 95% CI [-1.23, 0.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-22.35, 0.52], t(2068) = -1.87, p = 0.061; Std. beta = -0.96,
## 95% CI [-1.74, -0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -20.82, 95% CI [-36.50, -5.14], t(2068) = -2.60, p = 0.009; Std. beta = -2.40,
## 95% CI [-4.97, 0.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-31.46, 21.17], t(2068) = -0.38, p = 0.702; Std. beta = -0.65,
## 95% CI [-2.26, 0.96])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -5.30, 95% CI [-17.27, 6.66], t(2068) = -0.87, p = 0.385; Std. beta = -0.23,
## 95% CI [-0.98, 0.53])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-14.34, 13.09], t(2068) = -0.09, p = 0.928; Std. beta = -0.16,
## 95% CI [-1.12, 0.80])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-26.42, 0.25], t(2068) = -1.92, p = 0.055; Std. beta = -1.23,
## 95% CI [-2.24, -0.23])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-19.62, 1.02], t(2068) = -1.77, p = 0.077; Std. beta = -0.55,
## 95% CI [-1.25, 0.15])
## - The effect of site [35R] is statistically significant and negative (beta =
## -19.21, 95% CI [-35.09, -3.33], t(2068) = -2.37, p = 0.018; Std. beta = -0.44,
## 95% CI [-1.56, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.40, 95% CI [-12.39, 11.59], t(2068) = -0.07, p = 0.948; Std. beta = 0.49,
## 95% CI [-0.36, 1.34])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -2.52, 95% CI [-15.61, 10.58], t(2068) = -0.38, p = 0.706; Std. beta = -0.32,
## 95% CI [-1.19, 0.54])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.11, 95% CI [-16.65, 2.43], t(2068) = -1.46, p = 0.144; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-25.35, 27.15], t(2068) = 0.07, p = 0.946; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.23, 16.42], t(2068) = -0.20, p = 0.838; Std. beta = 0.06,
## 95% CI [-1.25, 1.38])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.25, 95% CI [-33.73, -2.76], t(2068) = -2.31, p = 0.021; Std. beta = -0.87,
## 95% CI [-2.24, 0.51])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.62, 95% CI [-21.59, -3.65], t(2068) = -2.76, p = 0.006; Std. beta = -1.16,
## 95% CI [-2.26, -0.06])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.25, 95% CI [-1.44, 1.95], t(2068) =
## 0.29, p = 0.770; Std. beta = 0.02, 95% CI [-0.11, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.55, 95% CI [-70.97, 1.86], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.28, 95% CI [-8.79, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-12.90, 10.70], t(2068) = -0.18, p = 0.855;
## Std. beta = -0.14, 95% CI [-1.60, 1.33])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-14.14, 10.58], t(2068) = -0.28, p = 0.778;
## Std. beta = -0.22, 95% CI [-1.75, 1.31])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.43, 11.33], t(2068) = -0.47, p = 0.640;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.27, 95% CI [-6.74, 13.28], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.41, 95% CI [-0.83, 1.64])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-5.72, 0.49], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.43, 9.48], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.13, 95% CI [-0.92, 1.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.39, 1.69], t(2068) = -0.66, p = 0.511; Std.
## beta = -0.11, 95% CI [-0.42, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-6.06, 3.20], t(2068) = -0.61, p = 0.544; Std.
## beta = -0.18, 95% CI [-0.75, 0.40])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-1.28, 4.16], t(2068) = 1.04, p = 0.298; Std.
## beta = 0.18, 95% CI [-0.16, 0.52])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.44, 95% CI [-5.14, 10.03], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.30, 95% CI [-0.64, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-2.77, 2.56], t(2068) = -0.08, p = 0.937; Std.
## beta = -0.01, 95% CI [-0.34, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-2.06, 4.79], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.17, 95% CI [-0.26, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.40, 95% CI [-29.50, 2.70], t(2068) = -1.63, p = 0.103;
## Std. beta = -1.66, 95% CI [-3.65, 0.33])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-3.08, 10.81], t(2068) = 1.09, p = 0.276; Std.
## beta = 0.48, 95% CI [-0.38, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-0.64, 10.86], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.63, 95% CI [-0.08, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-6.70, 9.51], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.17, 95% CI [-0.83, 1.18])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-8.42, 7.38], t(2068) = -0.13, p = 0.898; Std.
## beta = -0.06, 95% CI [-1.04, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-57.31, 35.64], t(2068) = -0.46, p = 0.648;
## Std. beta = -1.34, 95% CI [-7.10, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-29.77, 25.91], t(2068) = -0.14, p = 0.892;
## Std. beta = -0.24, 95% CI [-3.69, 3.21])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-6.61, 4.24], t(2068) = -0.43, p = 0.669; Std.
## beta = -0.15, 95% CI [-0.82, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.19, 14.82], t(2068) = -0.82, p = 0.411;
## Std. beta = -1.32, 95% CI [-4.48, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-7.19, 12.20], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.31, 95% CI [-0.89, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.96, 7.77], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.53, 95% CI [-4.01, 15.07], t(2068) = 1.14, p = 0.256; Std.
## beta = 0.69, 95% CI [-0.50, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-1.35, 9.93], t(2068) = 1.49, p = 0.136; Std.
## beta = 0.53, 95% CI [-0.17, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-11.59, 9.74], t(2068) = -0.17, p = 0.864; Std.
## beta = -0.12, 95% CI [-1.44, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-8.60, 1.64], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.43, 95% CI [-1.07, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-8.17, 3.94], t(2068) = -0.69, p = 0.493; Std.
## beta = -0.26, 95% CI [-1.01, 0.49])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.59, 95% CI [-35.24, 16.05], t(2068) = -0.73, p = 0.463;
## Std. beta = -1.19, 95% CI [-4.37, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-13.09, 7.26], t(2068) = -0.56, p = 0.574; Std.
## beta = -0.36, 95% CI [-1.62, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-2.92, 5.56], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-8.37, 6.08], t(2068) = -0.31, p = 0.756; Std.
## beta = -0.14, 95% CI [-1.04, 0.75])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-10.90, 4.21], t(2068) = -0.87, p = 0.386; Std.
## beta = -0.41, 95% CI [-1.35, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.79, 95% CI [-4.13, 5.72], t(2068) = 0.32, p = 0.752; Std.
## beta = 0.10, 95% CI [-0.51, 0.71])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.46, 95% CI [-0.79, 17.70], t(2068) = 1.79, p = 0.073; Std.
## beta = 1.05, 95% CI [-0.10, 2.19])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-0.92, 10.99], t(2068) = 1.66, p = 0.097; Std.
## beta = 0.62, 95% CI [-0.11, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.27, 4.31], t(2068) = -0.50, p = 0.617; Std.
## beta = -0.18, 95% CI [-0.90, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-6.09, 2.15], t(2068) = -0.94, p = 0.348; Std.
## beta = -0.24, 95% CI [-0.75, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.76, -9.64], t(2068) = -2.88, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.29, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-7.23, 10.99], t(2068) = 0.40, p = 0.686; Std.
## beta = 0.23, 95% CI [-0.90, 1.36])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-9.51, 16.81], t(2068) = 0.54, p = 0.587; Std.
## beta = 0.45, 95% CI [-1.18, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-14.61, 8.74], t(2068) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.33. The model's intercept, corresponding to site =
## Simmons, is at 47.61 (95% CI [42.19, 53.04], t(2068) = 17.21, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.62, 95% CI [-7.01, -2.23], t(2068) = -3.80, p < .001; Std. beta = -0.55, 95%
## CI [-0.72, -0.38])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.31, 95% CI [-8.98, -1.64], t(2068) = -2.84, p = 0.005; Std. beta =
## -0.20, 95% CI [-0.35, -0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.67, 95% CI [-34.49, 19.16], t(2068) = -0.56, p = 0.575; Std. beta = -4.07,
## 95% CI [-7.48, -0.67])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 19.70, 95% CI [-0.03, 39.44], t(2068) = 1.96, p = 0.050; Std. beta = 1.23,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-27.53, 9.07], t(2068) = -0.99, p = 0.323; Std. beta = -0.81,
## 95% CI [-2.25, 0.63])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.64, 95% CI [-32.07, -1.21], t(2068) = -2.12, p = 0.035; Std. beta = -1.50,
## 95% CI [-2.99, -1.56e-03])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 0.70, 95% CI [-18.42, 19.82], t(2068) = 0.07, p = 0.943; Std. beta = 0.38,
## 95% CI [-0.99, 1.75])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-6.58, 9.10], t(2068) = 0.32, p = 0.752; Std. beta = -0.18, 95%
## CI [-0.69, 0.32])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.53, 95% CI [-32.27, 5.22], t(2068) = -1.42, p = 0.157; Std. beta = -0.81,
## 95% CI [-2.10, 0.47])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.43, 95% CI [9.44, 21.42], t(2068) = 5.05, p < .001; Std. beta = 0.96, 95% CI
## [0.56, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-7.51, 13.55], t(2068) = 0.56, p = 0.574; Std. beta = 0.06, 95%
## CI [-0.64, 0.75])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.20, 95% CI [-14.41, -1.98], t(2068) = -2.58, p = 0.010; Std. beta = -0.41,
## 95% CI [-0.83, 0.01])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.88, 95% CI [-26.98, -4.77], t(2068) = -2.80, p = 0.005; Std. beta = -0.83,
## 95% CI [-1.74, 0.08])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.56, 95% CI [-9.73, 2.61], t(2068) = -1.13, p = 0.258; Std. beta = -0.25,
## 95% CI [-0.67, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.63, 95% CI [-14.84, -0.42], t(2068) = -2.08, p = 0.038; Std. beta = -0.38,
## 95% CI [-0.86, 0.10])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-13.75, 24.47], t(2068) = 0.55, p = 0.583; Std. beta = -1.01,
## 95% CI [-2.65, 0.62])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -14.10, 95% CI [-29.45, 1.24], t(2068) = -1.80, p = 0.072; Std. beta = -0.56,
## 95% CI [-1.56, 0.44])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.50, 95% CI [-33.87, 18.87], t(2068) = -0.56, p = 0.577; Std. beta = -0.51,
## 95% CI [-2.30, 1.28])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-17.98, 5.89], t(2068) = -0.99, p = 0.321; Std. beta = 0.11,
## 95% CI [-0.72, 0.95])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -14.50, 95% CI [-33.19, 4.18], t(2068) = -1.52, p = 0.128; Std. beta = -0.84,
## 95% CI [-2.13, 0.44])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.55, 95% CI [-29.23, 0.12], t(2068) = -1.95, p = 0.052; Std. beta = -1.04,
## 95% CI [-2.02, -0.07])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -11.30, 95% CI [-40.83, 18.23], t(2068) = -0.75, p = 0.453; Std. beta =
## -1.88, 95% CI [-5.30, 1.54])
## - The effect of site [15R] is statistically significant and negative (beta =
## -29.22, 95% CI [-56.18, -2.26], t(2068) = -2.13, p = 0.034; Std. beta = -2.19,
## 95% CI [-4.82, 0.44])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.99, 95% CI [-24.98, -1.00], t(2068) = -2.13, p = 0.034; Std. beta = -1.01,
## 95% CI [-1.84, -0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 54.95, 95% CI [28.12, 81.79], t(2068) = 4.02, p < .001; Std. beta = 3.74, 95%
## CI [1.91, 5.56])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.34, 95% CI [-29.60, 8.93], t(2068) = -1.05, p = 0.293; Std. beta = -1.80,
## 95% CI [-4.33, 0.72])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.76, 95% CI [-24.59, 1.07], t(2068) = -1.80, p = 0.072; Std. beta = -0.54,
## 95% CI [-1.62, 0.54])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-19.11, 3.74], t(2068) = -1.32, p = 0.187; Std. beta = -0.43,
## 95% CI [-1.27, 0.41])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.29, 95% CI [-43.43, 6.85], t(2068) = -1.43, p = 0.154; Std. beta = -0.68,
## 95% CI [-2.26, 0.91])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.97, 95% CI [-23.77, -6.18], t(2068) = -3.34, p < .001; Std. beta = -0.58,
## 95% CI [-1.24, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.59, 95% CI [-36.07, -11.11], t(2068) = -3.71, p < .001; Std. beta = -1.70,
## 95% CI [-2.88, -0.52])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-12.87, 7.98], t(2068) = -0.46, p = 0.646; Std. beta = -0.52,
## 95% CI [-1.23, 0.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-22.35, 0.52], t(2068) = -1.87, p = 0.061; Std. beta = -0.96,
## 95% CI [-1.74, -0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -20.82, 95% CI [-36.50, -5.14], t(2068) = -2.60, p = 0.009; Std. beta = -2.40,
## 95% CI [-4.97, 0.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-31.46, 21.17], t(2068) = -0.38, p = 0.702; Std. beta = -0.65,
## 95% CI [-2.26, 0.96])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -5.30, 95% CI [-17.27, 6.66], t(2068) = -0.87, p = 0.385; Std. beta = -0.23,
## 95% CI [-0.98, 0.53])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-14.34, 13.09], t(2068) = -0.09, p = 0.928; Std. beta = -0.16,
## 95% CI [-1.12, 0.80])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-26.42, 0.25], t(2068) = -1.92, p = 0.055; Std. beta = -1.23,
## 95% CI [-2.24, -0.23])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-19.62, 1.02], t(2068) = -1.77, p = 0.077; Std. beta = -0.55,
## 95% CI [-1.25, 0.15])
## - The effect of site [35R] is statistically significant and negative (beta =
## -19.21, 95% CI [-35.09, -3.33], t(2068) = -2.37, p = 0.018; Std. beta = -0.44,
## 95% CI [-1.56, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.40, 95% CI [-12.39, 11.59], t(2068) = -0.07, p = 0.948; Std. beta = 0.49,
## 95% CI [-0.36, 1.34])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -2.52, 95% CI [-15.61, 10.58], t(2068) = -0.38, p = 0.706; Std. beta = -0.32,
## 95% CI [-1.19, 0.54])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.11, 95% CI [-16.65, 2.43], t(2068) = -1.46, p = 0.144; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-25.35, 27.15], t(2068) = 0.07, p = 0.946; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.23, 16.42], t(2068) = -0.20, p = 0.838; Std. beta = 0.06,
## 95% CI [-1.25, 1.38])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.25, 95% CI [-33.73, -2.76], t(2068) = -2.31, p = 0.021; Std. beta = -0.87,
## 95% CI [-2.24, 0.51])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.62, 95% CI [-21.59, -3.65], t(2068) = -2.76, p = 0.006; Std. beta = -1.16,
## 95% CI [-2.26, -0.06])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.25, 95% CI [-1.44, 1.95], t(2068) =
## 0.29, p = 0.770; Std. beta = 0.02, 95% CI [-0.11, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.55, 95% CI [-70.97, 1.86], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.28, 95% CI [-8.79, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-12.90, 10.70], t(2068) = -0.18, p = 0.855;
## Std. beta = -0.14, 95% CI [-1.60, 1.33])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-14.14, 10.58], t(2068) = -0.28, p = 0.778;
## Std. beta = -0.22, 95% CI [-1.75, 1.31])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.43, 11.33], t(2068) = -0.47, p = 0.640;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.27, 95% CI [-6.74, 13.28], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.41, 95% CI [-0.83, 1.64])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-5.72, 0.49], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.43, 9.48], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.13, 95% CI [-0.92, 1.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.39, 1.69], t(2068) = -0.66, p = 0.511; Std.
## beta = -0.11, 95% CI [-0.42, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-6.06, 3.20], t(2068) = -0.61, p = 0.544; Std.
## beta = -0.18, 95% CI [-0.75, 0.40])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-1.28, 4.16], t(2068) = 1.04, p = 0.298; Std.
## beta = 0.18, 95% CI [-0.16, 0.52])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.44, 95% CI [-5.14, 10.03], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.30, 95% CI [-0.64, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-2.77, 2.56], t(2068) = -0.08, p = 0.937; Std.
## beta = -0.01, 95% CI [-0.34, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-2.06, 4.79], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.17, 95% CI [-0.26, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.40, 95% CI [-29.50, 2.70], t(2068) = -1.63, p = 0.103;
## Std. beta = -1.66, 95% CI [-3.65, 0.33])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-3.08, 10.81], t(2068) = 1.09, p = 0.276; Std.
## beta = 0.48, 95% CI [-0.38, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-0.64, 10.86], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.63, 95% CI [-0.08, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-6.70, 9.51], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.17, 95% CI [-0.83, 1.18])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-8.42, 7.38], t(2068) = -0.13, p = 0.898; Std.
## beta = -0.06, 95% CI [-1.04, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-57.31, 35.64], t(2068) = -0.46, p = 0.648;
## Std. beta = -1.34, 95% CI [-7.10, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-29.77, 25.91], t(2068) = -0.14, p = 0.892;
## Std. beta = -0.24, 95% CI [-3.69, 3.21])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-6.61, 4.24], t(2068) = -0.43, p = 0.669; Std.
## beta = -0.15, 95% CI [-0.82, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.19, 14.82], t(2068) = -0.82, p = 0.411;
## Std. beta = -1.32, 95% CI [-4.48, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-7.19, 12.20], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.31, 95% CI [-0.89, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.96, 7.77], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.53, 95% CI [-4.01, 15.07], t(2068) = 1.14, p = 0.256; Std.
## beta = 0.69, 95% CI [-0.50, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-1.35, 9.93], t(2068) = 1.49, p = 0.136; Std.
## beta = 0.53, 95% CI [-0.17, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-11.59, 9.74], t(2068) = -0.17, p = 0.864; Std.
## beta = -0.12, 95% CI [-1.44, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-8.60, 1.64], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.43, 95% CI [-1.07, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-8.17, 3.94], t(2068) = -0.69, p = 0.493; Std.
## beta = -0.26, 95% CI [-1.01, 0.49])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.59, 95% CI [-35.24, 16.05], t(2068) = -0.73, p = 0.463;
## Std. beta = -1.19, 95% CI [-4.37, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-13.09, 7.26], t(2068) = -0.56, p = 0.574; Std.
## beta = -0.36, 95% CI [-1.62, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-2.92, 5.56], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-8.37, 6.08], t(2068) = -0.31, p = 0.756; Std.
## beta = -0.14, 95% CI [-1.04, 0.75])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-10.90, 4.21], t(2068) = -0.87, p = 0.386; Std.
## beta = -0.41, 95% CI [-1.35, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.79, 95% CI [-4.13, 5.72], t(2068) = 0.32, p = 0.752; Std.
## beta = 0.10, 95% CI [-0.51, 0.71])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.46, 95% CI [-0.79, 17.70], t(2068) = 1.79, p = 0.073; Std.
## beta = 1.05, 95% CI [-0.10, 2.19])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-0.92, 10.99], t(2068) = 1.66, p = 0.097; Std.
## beta = 0.62, 95% CI [-0.11, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.27, 4.31], t(2068) = -0.50, p = 0.617; Std.
## beta = -0.18, 95% CI [-0.90, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-6.09, 2.15], t(2068) = -0.94, p = 0.348; Std.
## beta = -0.24, 95% CI [-0.75, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.76, -9.64], t(2068) = -2.88, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.29, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-7.23, 10.99], t(2068) = 0.40, p = 0.686; Std.
## beta = 0.23, 95% CI [-0.90, 1.36])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-9.51, 16.81], t(2068) = 0.54, p = 0.587; Std.
## beta = 0.45, 95% CI [-1.18, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-14.61, 8.74], t(2068) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to cohort = CARE-PF, is at 47.61 (95% CI [42.19, 53.04], t(2068)
## = 17.21, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.62, 95% CI [-7.01, -2.23], t(2068) = -3.80, p < .001; Std. beta = -0.55, 95%
## CI [-0.72, -0.38])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.31, 95% CI [-8.98, -1.64], t(2068) = -2.84, p = 0.005; Std. beta =
## -0.20, 95% CI [-0.35, -0.05])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.67, 95% CI [-34.49, 19.16], t(2068) = -0.56, p = 0.575; Std. beta = -4.07,
## 95% CI [-7.48, -0.67])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 19.70, 95% CI [-0.03, 39.44], t(2068) = 1.96, p = 0.050; Std. beta = 1.23,
## 95% CI [-0.06, 2.51])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.23, 95% CI [-27.53, 9.07], t(2068) = -0.99, p = 0.323; Std. beta = -0.81,
## 95% CI [-2.25, 0.63])
## - The effect of site [05R] is statistically significant and negative (beta =
## -16.64, 95% CI [-32.07, -1.21], t(2068) = -2.12, p = 0.035; Std. beta = -1.50,
## 95% CI [-2.99, -1.56e-03])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 0.70, 95% CI [-18.42, 19.82], t(2068) = 0.07, p = 0.943; Std. beta = 0.38,
## 95% CI [-0.99, 1.75])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.26, 95% CI [-6.58, 9.10], t(2068) = 0.32, p = 0.752; Std. beta = -0.18, 95%
## CI [-0.69, 0.32])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -13.53, 95% CI [-32.27, 5.22], t(2068) = -1.42, p = 0.157; Std. beta = -0.81,
## 95% CI [-2.10, 0.47])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.43, 95% CI [9.44, 21.42], t(2068) = 5.05, p < .001; Std. beta = 0.96, 95% CI
## [0.56, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 3.02, 95% CI [-7.51, 13.55], t(2068) = 0.56, p = 0.574; Std. beta = 0.06, 95%
## CI [-0.64, 0.75])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.20, 95% CI [-14.41, -1.98], t(2068) = -2.58, p = 0.010; Std. beta = -0.41,
## 95% CI [-0.83, 0.01])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.88, 95% CI [-26.98, -4.77], t(2068) = -2.80, p = 0.005; Std. beta = -0.83,
## 95% CI [-1.74, 0.08])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.56, 95% CI [-9.73, 2.61], t(2068) = -1.13, p = 0.258; Std. beta = -0.25,
## 95% CI [-0.67, 0.16])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.63, 95% CI [-14.84, -0.42], t(2068) = -2.08, p = 0.038; Std. beta = -0.38,
## 95% CI [-0.86, 0.10])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 5.36, 95% CI [-13.75, 24.47], t(2068) = 0.55, p = 0.583; Std. beta = -1.01,
## 95% CI [-2.65, 0.62])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -14.10, 95% CI [-29.45, 1.24], t(2068) = -1.80, p = 0.072; Std. beta = -0.56,
## 95% CI [-1.56, 0.44])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.50, 95% CI [-33.87, 18.87], t(2068) = -0.56, p = 0.577; Std. beta = -0.51,
## 95% CI [-2.30, 1.28])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -6.04, 95% CI [-17.98, 5.89], t(2068) = -0.99, p = 0.321; Std. beta = 0.11,
## 95% CI [-0.72, 0.95])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -14.50, 95% CI [-33.19, 4.18], t(2068) = -1.52, p = 0.128; Std. beta = -0.84,
## 95% CI [-2.13, 0.44])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -14.55, 95% CI [-29.23, 0.12], t(2068) = -1.95, p = 0.052; Std. beta = -1.04,
## 95% CI [-2.02, -0.07])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -11.30, 95% CI [-40.83, 18.23], t(2068) = -0.75, p = 0.453; Std. beta =
## -1.88, 95% CI [-5.30, 1.54])
## - The effect of site [15R] is statistically significant and negative (beta =
## -29.22, 95% CI [-56.18, -2.26], t(2068) = -2.13, p = 0.034; Std. beta = -2.19,
## 95% CI [-4.82, 0.44])
## - The effect of site [16R] is statistically significant and negative (beta =
## -12.99, 95% CI [-24.98, -1.00], t(2068) = -2.13, p = 0.034; Std. beta = -1.01,
## 95% CI [-1.84, -0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 54.95, 95% CI [28.12, 81.79], t(2068) = 4.02, p < .001; Std. beta = 3.74, 95%
## CI [1.91, 5.56])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -10.34, 95% CI [-29.60, 8.93], t(2068) = -1.05, p = 0.293; Std. beta = -1.80,
## 95% CI [-4.33, 0.72])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -11.76, 95% CI [-24.59, 1.07], t(2068) = -1.80, p = 0.072; Std. beta = -0.54,
## 95% CI [-1.62, 0.54])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -7.68, 95% CI [-19.11, 3.74], t(2068) = -1.32, p = 0.187; Std. beta = -0.43,
## 95% CI [-1.27, 0.41])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.29, 95% CI [-43.43, 6.85], t(2068) = -1.43, p = 0.154; Std. beta = -0.68,
## 95% CI [-2.26, 0.91])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.97, 95% CI [-23.77, -6.18], t(2068) = -3.34, p < .001; Std. beta = -0.58,
## 95% CI [-1.24, 0.09])
## - The effect of site [23R] is statistically significant and negative (beta =
## -23.59, 95% CI [-36.07, -11.11], t(2068) = -3.71, p < .001; Std. beta = -1.70,
## 95% CI [-2.88, -0.52])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -2.44, 95% CI [-12.87, 7.98], t(2068) = -0.46, p = 0.646; Std. beta = -0.52,
## 95% CI [-1.23, 0.18])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.91, 95% CI [-22.35, 0.52], t(2068) = -1.87, p = 0.061; Std. beta = -0.96,
## 95% CI [-1.74, -0.18])
## - The effect of site [28R] is statistically significant and negative (beta =
## -20.82, 95% CI [-36.50, -5.14], t(2068) = -2.60, p = 0.009; Std. beta = -2.40,
## 95% CI [-4.97, 0.16])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.14, 95% CI [-31.46, 21.17], t(2068) = -0.38, p = 0.702; Std. beta = -0.65,
## 95% CI [-2.26, 0.96])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -5.30, 95% CI [-17.27, 6.66], t(2068) = -0.87, p = 0.385; Std. beta = -0.23,
## 95% CI [-0.98, 0.53])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -0.63, 95% CI [-14.34, 13.09], t(2068) = -0.09, p = 0.928; Std. beta = -0.16,
## 95% CI [-1.12, 0.80])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -13.08, 95% CI [-26.42, 0.25], t(2068) = -1.92, p = 0.055; Std. beta = -1.23,
## 95% CI [-2.24, -0.23])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-19.62, 1.02], t(2068) = -1.77, p = 0.077; Std. beta = -0.55,
## 95% CI [-1.25, 0.15])
## - The effect of site [35R] is statistically significant and negative (beta =
## -19.21, 95% CI [-35.09, -3.33], t(2068) = -2.37, p = 0.018; Std. beta = -0.44,
## 95% CI [-1.56, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -0.40, 95% CI [-12.39, 11.59], t(2068) = -0.07, p = 0.948; Std. beta = 0.49,
## 95% CI [-0.36, 1.34])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -2.52, 95% CI [-15.61, 10.58], t(2068) = -0.38, p = 0.706; Std. beta = -0.32,
## 95% CI [-1.19, 0.54])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.11, 95% CI [-16.65, 2.43], t(2068) = -1.46, p = 0.144; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 0.90, 95% CI [-25.35, 27.15], t(2068) = 0.07, p = 0.946; Std. beta = -3.04,
## 95% CI [-5.20, -0.88])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -1.91, 95% CI [-20.23, 16.42], t(2068) = -0.20, p = 0.838; Std. beta = 0.06,
## 95% CI [-1.25, 1.38])
## - The effect of site [41R] is statistically significant and negative (beta =
## -18.25, 95% CI [-33.73, -2.76], t(2068) = -2.31, p = 0.021; Std. beta = -0.87,
## 95% CI [-2.24, 0.51])
## - The effect of site [42R] is statistically significant and negative (beta =
## -12.62, 95% CI [-21.59, -3.65], t(2068) = -2.76, p = 0.006; Std. beta = -1.16,
## 95% CI [-2.26, -0.06])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.25, 95% CI [-1.44, 1.95], t(2068) =
## 0.29, p = 0.770; Std. beta = 0.02, 95% CI [-0.11, 0.14])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.55, 95% CI [-70.97, 1.86], t(2068) = -1.86, p = 0.063;
## Std. beta = -4.28, 95% CI [-8.79, 0.23])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-12.90, 10.70], t(2068) = -0.18, p = 0.855;
## Std. beta = -0.14, 95% CI [-1.60, 1.33])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.78, 95% CI [-14.14, 10.58], t(2068) = -0.28, p = 0.778;
## Std. beta = -0.22, 95% CI [-1.75, 1.31])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.43, 11.33], t(2068) = -0.47, p = 0.640;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.27, 95% CI [-6.74, 13.28], t(2068) = 0.64, p = 0.522; Std.
## beta = 0.41, 95% CI [-0.83, 1.64])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-5.72, 0.49], t(2068) = -1.65, p = 0.098; Std.
## beta = -0.32, 95% CI [-0.71, 0.06])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-7.43, 9.48], t(2068) = 0.24, p = 0.812; Std.
## beta = 0.13, 95% CI [-0.92, 1.17])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-3.39, 1.69], t(2068) = -0.66, p = 0.511; Std.
## beta = -0.11, 95% CI [-0.42, 0.21])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.43, 95% CI [-6.06, 3.20], t(2068) = -0.61, p = 0.544; Std.
## beta = -0.18, 95% CI [-0.75, 0.40])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.44, 95% CI [-1.28, 4.16], t(2068) = 1.04, p = 0.298; Std.
## beta = 0.18, 95% CI [-0.16, 0.52])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.44, 95% CI [-5.14, 10.03], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.30, 95% CI [-0.64, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.11, 95% CI [-2.77, 2.56], t(2068) = -0.08, p = 0.937; Std.
## beta = -0.01, 95% CI [-0.34, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.36, 95% CI [-2.06, 4.79], t(2068) = 0.78, p = 0.436; Std.
## beta = 0.17, 95% CI [-0.26, 0.59])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.40, 95% CI [-29.50, 2.70], t(2068) = -1.63, p = 0.103;
## Std. beta = -1.66, 95% CI [-3.65, 0.33])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.86, 95% CI [-3.08, 10.81], t(2068) = 1.09, p = 0.276; Std.
## beta = 0.48, 95% CI [-0.38, 1.34])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.11, 95% CI [-0.64, 10.86], t(2068) = 1.74, p = 0.082; Std.
## beta = 0.63, 95% CI [-0.08, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-6.70, 9.51], t(2068) = 0.34, p = 0.734; Std.
## beta = 0.17, 95% CI [-0.83, 1.18])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-8.42, 7.38], t(2068) = -0.13, p = 0.898; Std.
## beta = -0.06, 95% CI [-1.04, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.83, 95% CI [-57.31, 35.64], t(2068) = -0.46, p = 0.648;
## Std. beta = -1.34, 95% CI [-7.10, 4.41])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.93, 95% CI [-29.77, 25.91], t(2068) = -0.14, p = 0.892;
## Std. beta = -0.24, 95% CI [-3.69, 3.21])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-6.61, 4.24], t(2068) = -0.43, p = 0.669; Std.
## beta = -0.15, 95% CI [-0.82, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.19, 14.82], t(2068) = -0.82, p = 0.411;
## Std. beta = -1.32, 95% CI [-4.48, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.50, 95% CI [-7.19, 12.20], t(2068) = 0.51, p = 0.612; Std.
## beta = 0.31, 95% CI [-0.89, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.90, 95% CI [-5.96, 7.77], t(2068) = 0.26, p = 0.796; Std.
## beta = 0.11, 95% CI [-0.74, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.53, 95% CI [-4.01, 15.07], t(2068) = 1.14, p = 0.256; Std.
## beta = 0.69, 95% CI [-0.50, 1.87])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.29, 95% CI [-1.35, 9.93], t(2068) = 1.49, p = 0.136; Std.
## beta = 0.53, 95% CI [-0.17, 1.23])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-11.59, 9.74], t(2068) = -0.17, p = 0.864; Std.
## beta = -0.12, 95% CI [-1.44, 1.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.48, 95% CI [-8.60, 1.64], t(2068) = -1.33, p = 0.183; Std.
## beta = -0.43, 95% CI [-1.07, 0.20])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-8.17, 3.94], t(2068) = -0.69, p = 0.493; Std.
## beta = -0.26, 95% CI [-1.01, 0.49])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.59, 95% CI [-35.24, 16.05], t(2068) = -0.73, p = 0.463;
## Std. beta = -1.19, 95% CI [-4.37, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.92, 95% CI [-13.09, 7.26], t(2068) = -0.56, p = 0.574; Std.
## beta = -0.36, 95% CI [-1.62, 0.90])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.32, 95% CI [-2.92, 5.56], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.16, 95% CI [-0.36, 0.69])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.15, 95% CI [-8.37, 6.08], t(2068) = -0.31, p = 0.756; Std.
## beta = -0.14, 95% CI [-1.04, 0.75])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-10.90, 4.21], t(2068) = -0.87, p = 0.386; Std.
## beta = -0.41, 95% CI [-1.35, 0.52])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.79, 95% CI [-4.13, 5.72], t(2068) = 0.32, p = 0.752; Std.
## beta = 0.10, 95% CI [-0.51, 0.71])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.46, 95% CI [-0.79, 17.70], t(2068) = 1.79, p = 0.073; Std.
## beta = 1.05, 95% CI [-0.10, 2.19])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.03, 95% CI [-0.92, 10.99], t(2068) = 1.66, p = 0.097; Std.
## beta = 0.62, 95% CI [-0.11, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.48, 95% CI [-7.27, 4.31], t(2068) = -0.50, p = 0.617; Std.
## beta = -0.18, 95% CI [-0.90, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.97, 95% CI [-6.09, 2.15], t(2068) = -0.94, p = 0.348; Std.
## beta = -0.24, 95% CI [-0.75, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.20, 95% CI [-50.76, -9.64], t(2068) = -2.88, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.29, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-7.23, 10.99], t(2068) = 0.40, p = 0.686; Std.
## beta = 0.23, 95% CI [-0.90, 1.36])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.65, 95% CI [-9.51, 16.81], t(2068) = 0.54, p = 0.587; Std.
## beta = 0.45, 95% CI [-1.18, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.93, 95% CI [-14.61, 8.74], t(2068) = -0.49, p = 0.622; Std.
## beta = -0.36, 95% CI [-1.81, 1.08])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*NH4_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14882.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1119 -0.4869 -0.0080 0.4455 7.0972
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 135.79 11.653
## time_firstPFT 11.28 3.358 -0.29
## Residual 41.84 6.468
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 45.66459 5.46762 8.352
## time_firstPFT -2.92965 2.50465 -1.170
## NH4_5yrPreCensor -5.85957 1.91990 -3.052
## disadv -6.48607 2.34034 -2.771
## dich_RaceNon-White -2.33559 2.27463 -1.027
## sexF -2.34226 1.40425 -1.668
## age_dx 0.14303 0.07341 1.948
## smokeHxFormer -2.71042 1.39874 -1.938
## smokeHxAlways 9.81601 6.99851 1.403
## smokeHxUnknown -1.33232 3.19660 -0.417
## site02R -12.41145 13.55137 -0.916
## site03R 14.58896 10.04959 1.452
## site04R -9.02685 9.18671 -0.983
## site05R -17.30298 7.78210 -2.223
## site06R -12.18878 13.45787 -0.906
## site07R -0.96131 3.97245 -0.242
## site09R -16.61694 9.47247 -1.754
## site101 15.09140 3.04894 4.950
## site102 1.04448 5.38744 0.194
## site103 -8.77220 3.25724 -2.693
## site104 -15.42963 5.62858 -2.741
## site105 -3.48427 3.13397 -1.112
## site106 -10.15937 3.71204 -2.737
## site107 2.20746 9.64516 0.229
## site108 -9.92517 8.09562 -1.226
## site10R -7.30733 13.43050 -0.544
## site11R -7.53406 6.00568 -1.254
## site12R -13.58140 9.38891 -1.447
## site13R -16.81881 7.42813 -2.264
## site14R -14.07991 15.00422 -0.938
## site15R -26.16078 13.59335 -1.925
## site16R -13.40961 6.14104 -2.184
## site17R 58.64900 13.62007 4.306
## site18R -8.96959 9.69677 -0.925
## site19R -13.67714 6.51198 -2.100
## site20R -8.56755 5.77509 -1.484
## site21R -18.42269 12.59780 -1.462
## site22R -18.11538 4.51400 -4.013
## site23R -30.61599 7.84206 -3.904
## site24R -3.49644 5.25384 -0.666
## site25R -14.18138 5.84745 -2.425
## site28R -19.59608 7.93047 -2.471
## site29R -9.83308 13.29165 -0.740
## site31R -6.96801 6.13325 -1.136
## site32R -1.11962 6.94802 -0.161
## site33R -14.05034 6.73129 -2.087
## site34R -9.76839 5.19547 -1.880
## site35R -20.59543 8.03412 -2.563
## site36R -1.14967 6.04951 -0.190
## site37R -4.73690 6.67222 -0.710
## site38R -7.08010 4.80972 -1.472
## site39R 7.69597 13.44848 0.572
## site40R -3.49189 9.21414 -0.379
## site41R -19.84086 7.87328 -2.520
## site42R -15.05588 4.57737 -3.289
## time_firstPFT:NH4_5yrPreCensor 0.06961 0.91270 0.076
## time_firstPFT:disadv 1.51513 1.12645 1.345
## time_firstPFT:dich_RaceNon-White -0.49761 1.12144 -0.444
## time_firstPFT:sexF 0.73444 0.65884 1.115
## time_firstPFT:age_dx -0.03864 0.03447 -1.121
## time_firstPFT:smokeHxFormer -0.67684 0.67539 -1.002
## time_firstPFT:smokeHxAlways -6.43580 6.03849 -1.066
## time_firstPFT:smokeHxUnknown 2.30920 1.69670 1.361
## time_firstPFT:site02R -32.92611 18.58932 -1.771
## time_firstPFT:site03R -0.79897 6.07072 -0.132
## time_firstPFT:site04R -2.50818 6.33015 -0.396
## time_firstPFT:site05R -3.51381 7.60450 -0.462
## time_firstPFT:site07R -2.07089 1.62620 -1.273
## time_firstPFT:site09R 2.09864 4.33771 0.484
## time_firstPFT:site101 -0.74474 1.30927 -0.569
## time_firstPFT:site102 -0.85204 2.40261 -0.355
## time_firstPFT:site103 1.60358 1.46765 1.093
## time_firstPFT:site104 1.84355 3.91864 0.470
## time_firstPFT:site105 -0.09284 1.37333 -0.068
## time_firstPFT:site106 1.86182 1.79941 1.035
## time_firstPFT:site107 -12.57930 8.22594 -1.529
## time_firstPFT:site108 4.34333 3.74798 1.159
## time_firstPFT:site11R 5.66648 2.99193 1.894
## time_firstPFT:site12R 1.80569 4.14637 0.435
## time_firstPFT:site13R -0.49772 4.06838 -0.122
## time_firstPFT:site14R -9.62212 23.71355 -0.406
## time_firstPFT:site15R -2.37384 14.20850 -0.167
## time_firstPFT:site16R -1.36880 2.83195 -0.483
## time_firstPFT:site18R -10.69014 13.01268 -0.822
## time_firstPFT:site19R 2.35621 5.01822 0.470
## time_firstPFT:site20R 0.62668 3.55783 0.176
## time_firstPFT:site21R 6.02641 4.85953 1.240
## time_firstPFT:site22R 5.47799 2.93255 1.868
## time_firstPFT:site23R 21.95066 26.67591 0.823
## time_firstPFT:site24R -3.17310 2.61870 -1.212
## time_firstPFT:site25R -1.20630 3.15972 -0.382
## time_firstPFT:site28R -8.87128 13.15278 -0.674
## time_firstPFT:site29R -1.32944 5.23864 -0.254
## time_firstPFT:site31R 1.99523 2.24609 0.888
## time_firstPFT:site32R -0.73791 3.72114 -0.198
## time_firstPFT:site33R -3.85145 3.90295 -0.987
## time_firstPFT:site34R 0.87538 2.53065 0.346
## time_firstPFT:site35R 9.27580 4.74955 1.953
## time_firstPFT:site36R 5.08832 3.05226 1.667
## time_firstPFT:site37R -1.18234 3.07621 -0.384
## time_firstPFT:site38R -2.00316 2.11730 -0.946
## time_firstPFT:site39R -30.53320 10.56443 -2.890
## time_firstPFT:site40R 1.43401 4.69416 0.305
## time_firstPFT:site41R 4.47353 6.73549 0.664
## time_firstPFT:site42R -3.26192 5.97079 -0.546##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.797
## Unadjusted ICC: 0.528report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## NH4_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 45.66 (95% CI [34.94, 56.39], t(2038)
## = 8.35, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## NH4_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to
## NH4_5yrPreCensor = 0, is at 45.66 (95% CI [34.94, 56.39], t(2038) = 8.35, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to disadv = 0,
## is at 45.66 (95% CI [34.94, 56.39], t(2038) = 8.35, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to dich_Race =
## White, is at 45.66 (95% CI [34.94, 56.39], t(2038) = 8.35, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 45.66 (95% CI [34.94,
## 56.39], t(2038) = 8.35, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to age_dx = 0,
## is at 45.66 (95% CI [34.94, 56.39], t(2038) = 8.35, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to smokeHx =
## Never, is at 45.66 (95% CI [34.94, 56.39], t(2038) = 8.35, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 45.66 (95% CI [34.94,
## 56.39], t(2038) = 8.35, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * NH4_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 45.66 (95% CI [34.94, 56.39], t(2038) = 8.35, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -2.93, 95% CI [-7.84, 1.98], t(2038) = -1.17, p = 0.242; Std. beta =
## -0.55, 95% CI [-0.77, -0.33])
## - The effect of NH4 5yrPreCensor is statistically significant and negative
## (beta = -5.86, 95% CI [-9.62, -2.09], t(2038) = -3.05, p = 0.002; Std. beta =
## -0.23, 95% CI [-0.39, -0.07])
## - The effect of disadv is statistically significant and negative (beta = -6.49,
## 95% CI [-11.08, -1.90], t(2038) = -2.77, p = 0.006; Std. beta = -0.08, 95% CI
## [-0.17, 0.01])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.34, 95% CI [-6.80, 2.13], t(2038) = -1.03, p = 0.305; Std.
## beta = -0.21, 95% CI [-0.52, 0.10])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.34, 95% CI [-5.10, 0.41], t(2038) = -1.67, p = 0.095; Std. beta = -0.08, 95%
## CI [-0.27, 0.11])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-9.41e-04, 0.29], t(2038) = 1.95, p = 0.052; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.71, 95% CI [-5.45, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.25, 95% CI [-0.44, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.82, 95% CI [-3.91, 23.54], t(2038) = 1.40, p = 0.161; Std. beta =
## 3.26e-03, 95% CI [-1.24, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -1.33, 95% CI [-7.60, 4.94], t(2038) = -0.42, p = 0.677; Std. beta =
## 0.15, 95% CI [-0.32, 0.61])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -12.41, 95% CI [-38.99, 14.16], t(2038) = -0.92, p = 0.360; Std. beta =
## -4.24, 95% CI [-7.66, -0.82])
## - The effect of site [03R] is statistically non-significant and positive (beta
## = 14.59, 95% CI [-5.12, 34.30], t(2038) = 1.45, p = 0.147; Std. beta = 0.91,
## 95% CI [-0.39, 2.21])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -9.03, 95% CI [-27.04, 8.99], t(2038) = -0.98, p = 0.326; Std. beta = -0.87,
## 95% CI [-2.32, 0.57])
## - The effect of site [05R] is statistically significant and negative (beta =
## -17.30, 95% CI [-32.56, -2.04], t(2038) = -2.22, p = 0.026; Std. beta = -1.54,
## 95% CI [-3.04, -0.04])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -12.19, 95% CI [-38.58, 14.20], t(2038) = -0.91, p = 0.365; Std. beta =
## -0.83, 95% CI [-2.62, 0.97])
## - The effect of site [07R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-8.75, 6.83], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.79, 0.23])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -16.62, 95% CI [-35.19, 1.96], t(2038) = -1.75, p = 0.080; Std. beta = -0.91,
## 95% CI [-2.20, 0.37])
## - The effect of site [101] is statistically significant and positive (beta =
## 15.09, 95% CI [9.11, 21.07], t(2038) = 4.95, p < .001; Std. beta = 0.95, 95% CI
## [0.54, 1.36])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 1.04, 95% CI [-9.52, 11.61], t(2038) = 0.19, p = 0.846; Std. beta = -0.02,
## 95% CI [-0.72, 0.69])
## - The effect of site [103] is statistically significant and negative (beta =
## -8.77, 95% CI [-15.16, -2.38], t(2038) = -2.69, p = 0.007; Std. beta = -0.43,
## 95% CI [-0.87, 8.75e-03])
## - The effect of site [104] is statistically significant and negative (beta =
## -15.43, 95% CI [-26.47, -4.39], t(2038) = -2.74, p = 0.006; Std. beta = -0.86,
## 95% CI [-1.78, 0.06])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -3.48, 95% CI [-9.63, 2.66], t(2038) = -1.11, p = 0.266; Std. beta = -0.25,
## 95% CI [-0.66, 0.17])
## - The effect of site [106] is statistically significant and negative (beta =
## -10.16, 95% CI [-17.44, -2.88], t(2038) = -2.74, p = 0.006; Std. beta = -0.50,
## 95% CI [-0.99, -8.30e-03])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 2.21, 95% CI [-16.71, 21.12], t(2038) = 0.23, p = 0.819; Std. beta = -1.15,
## 95% CI [-2.79, 0.49])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.93, 95% CI [-25.80, 5.95], t(2038) = -1.23, p = 0.220; Std. beta = -0.23,
## 95% CI [-1.28, 0.83])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -7.31, 95% CI [-33.65, 19.03], t(2038) = -0.54, p = 0.586; Std. beta = -0.50,
## 95% CI [-2.29, 1.29])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-19.31, 4.24], t(2038) = -1.25, p = 0.210; Std. beta = 0.07,
## 95% CI [-0.77, 0.91])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.58, 95% CI [-31.99, 4.83], t(2038) = -1.45, p = 0.148; Std. beta = -0.74,
## 95% CI [-2.02, 0.55])
## - The effect of site [13R] is statistically significant and negative (beta =
## -16.82, 95% CI [-31.39, -2.25], t(2038) = -2.26, p = 0.024; Std. beta = -1.19,
## 95% CI [-2.18, -0.21])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -14.08, 95% CI [-43.51, 15.35], t(2038) = -0.94, p = 0.348; Std. beta =
## -1.95, 95% CI [-5.38, 1.49])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -26.16, 95% CI [-52.82, 0.50], t(2038) = -1.92, p = 0.054; Std. beta = -2.02,
## 95% CI [-4.66, 0.62])
## - The effect of site [16R] is statistically significant and negative (beta =
## -13.41, 95% CI [-25.45, -1.37], t(2038) = -2.18, p = 0.029; Std. beta = -1.05,
## 95% CI [-1.90, -0.21])
## - The effect of site [17R] is statistically significant and positive (beta =
## 58.65, 95% CI [31.94, 85.36], t(2038) = 4.31, p < .001; Std. beta = 3.99, 95%
## CI [2.17, 5.80])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -8.97, 95% CI [-27.99, 10.05], t(2038) = -0.93, p = 0.355; Std. beta = -1.71,
## 95% CI [-4.24, 0.82])
## - The effect of site [19R] is statistically significant and negative (beta =
## -13.68, 95% CI [-26.45, -0.91], t(2038) = -2.10, p = 0.036; Std. beta = -0.69,
## 95% CI [-1.78, 0.41])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -8.57, 95% CI [-19.89, 2.76], t(2038) = -1.48, p = 0.138; Std. beta = -0.52,
## 95% CI [-1.37, 0.33])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -18.42, 95% CI [-43.13, 6.28], t(2038) = -1.46, p = 0.144; Std. beta = -0.63,
## 95% CI [-2.21, 0.95])
## - The effect of site [22R] is statistically significant and negative (beta =
## -18.12, 95% CI [-26.97, -9.26], t(2038) = -4.01, p < .001; Std. beta = -0.67,
## 95% CI [-1.34, 9.29e-03])
## - The effect of site [23R] is statistically significant and negative (beta =
## -30.62, 95% CI [-46.00, -15.24], t(2038) = -3.90, p < .001; Std. beta = 0.18,
## 95% CI [-4.80, 5.17])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -3.50, 95% CI [-13.80, 6.81], t(2038) = -0.67, p = 0.506; Std. beta = -0.56,
## 95% CI [-1.27, 0.14])
## - The effect of site [25R] is statistically significant and negative (beta =
## -14.18, 95% CI [-25.65, -2.71], t(2038) = -2.43, p = 0.015; Std. beta = -1.09,
## 95% CI [-1.89, -0.29])
## - The effect of site [28R] is statistically significant and negative (beta =
## -19.60, 95% CI [-35.15, -4.04], t(2038) = -2.47, p = 0.014; Std. beta = -2.25,
## 95% CI [-4.84, 0.35])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-35.90, 16.23], t(2038) = -0.74, p = 0.460; Std. beta = -0.81,
## 95% CI [-2.42, 0.81])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -6.97, 95% CI [-19.00, 5.06], t(2038) = -1.14, p = 0.256; Std. beta = -0.27,
## 95% CI [-1.04, 0.51])
## - The effect of site [32R] is statistically non-significant and negative (beta
## = -1.12, 95% CI [-14.75, 12.51], t(2038) = -0.16, p = 0.872; Std. beta = -0.15,
## 95% CI [-1.12, 0.81])
## - The effect of site [33R] is statistically significant and negative (beta =
## -14.05, 95% CI [-27.25, -0.85], t(2038) = -2.09, p = 0.037; Std. beta = -1.35,
## 95% CI [-2.37, -0.34])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -9.77, 95% CI [-19.96, 0.42], t(2038) = -1.88, p = 0.060; Std. beta = -0.57,
## 95% CI [-1.28, 0.13])
## - The effect of site [35R] is statistically significant and negative (beta =
## -20.60, 95% CI [-36.35, -4.84], t(2038) = -2.56, p = 0.010; Std. beta = -0.44,
## 95% CI [-1.57, 0.68])
## - The effect of site [36R] is statistically non-significant and negative (beta
## = -1.15, 95% CI [-13.01, 10.71], t(2038) = -0.19, p = 0.849; Std. beta = 0.45,
## 95% CI [-0.40, 1.30])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -4.74, 95% CI [-17.82, 8.35], t(2038) = -0.71, p = 0.478; Std. beta = -0.44,
## 95% CI [-1.32, 0.44])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -7.08, 95% CI [-16.51, 2.35], t(2038) = -1.47, p = 0.141; Std. beta = -0.69,
## 95% CI [-1.32, -0.06])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.70, 95% CI [-18.68, 34.07], t(2038) = 0.57, p = 0.567; Std. beta = -2.63,
## 95% CI [-4.82, -0.43])
## - The effect of site [40R] is statistically non-significant and negative (beta
## = -3.49, 95% CI [-21.56, 14.58], t(2038) = -0.38, p = 0.705; Std. beta = -0.09,
## 95% CI [-1.41, 1.23])
## - The effect of site [41R] is statistically significant and negative (beta =
## -19.84, 95% CI [-35.28, -4.40], t(2038) = -2.52, p = 0.012; Std. beta = -0.89,
## 95% CI [-2.27, 0.50])
## - The effect of site [42R] is statistically significant and negative (beta =
## -15.06, 95% CI [-24.03, -6.08], t(2038) = -3.29, p = 0.001; Std. beta = -1.36,
## 95% CI [-2.47, -0.25])
## - The effect of time firstPFT × NH4 5yrPreCensor is statistically
## non-significant and positive (beta = 0.07, 95% CI [-1.72, 1.86], t(2038) =
## 0.08, p = 0.939; Std. beta = 5.18e-03, 95% CI [-0.13, 0.14])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.52, 95% CI [-0.69, 3.72], t(2038) = 1.35, p = 0.179; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.50, 95% CI [-2.70, 1.70], t(2038) =
## -0.44, p = 0.657; Std. beta = -0.06, 95% CI [-0.33, 0.21])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.03], t(2038) = 1.11, p = 0.265; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.12, p = 0.262; Std.
## beta = -0.04, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.65], t(2038) =
## -1.00, p = 0.316; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.44, 95% CI [-18.28, 5.41], t(2038) =
## -1.07, p = 0.287; Std. beta = -0.80, 95% CI [-2.27, 0.67])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.31, 95% CI [-1.02, 5.64], t(2038) =
## 1.36, p = 0.174; Std. beta = 0.29, 95% CI [-0.13, 0.70])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.93, 95% CI [-69.38, 3.53], t(2038) = -1.77, p = 0.077;
## Std. beta = -4.09, 95% CI [-8.61, 0.44])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-12.70, 11.11], t(2038) = -0.13, p = 0.895;
## Std. beta = -0.10, 95% CI [-1.58, 1.38])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.51, 95% CI [-14.92, 9.91], t(2038) = -0.40, p = 0.692; Std.
## beta = -0.31, 95% CI [-1.85, 1.23])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.51, 95% CI [-18.43, 11.40], t(2038) = -0.46, p = 0.644;
## Std. beta = -0.44, 95% CI [-2.29, 1.41])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-5.26, 1.12], t(2038) = -1.27, p = 0.203; Std.
## beta = -0.26, 95% CI [-0.65, 0.14])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.10, 95% CI [-6.41, 10.61], t(2038) = 0.48, p = 0.629; Std.
## beta = 0.26, 95% CI [-0.80, 1.32])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-3.31, 1.82], t(2038) = -0.57, p = 0.570; Std.
## beta = -0.09, 95% CI [-0.41, 0.23])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-5.56, 3.86], t(2038) = -0.35, p = 0.723; Std.
## beta = -0.11, 95% CI [-0.69, 0.48])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-1.27, 4.48], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.20, 95% CI [-0.16, 0.56])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.84, 95% CI [-5.84, 9.53], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.23, 95% CI [-0.72, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.09, 95% CI [-2.79, 2.60], t(2038) = -0.07, p = 0.946; Std.
## beta = -0.01, 95% CI [-0.35, 0.32])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.86, 95% CI [-1.67, 5.39], t(2038) = 1.03, p = 0.301; Std.
## beta = 0.23, 95% CI [-0.21, 0.67])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.58, 95% CI [-28.71, 3.55], t(2038) = -1.53, p = 0.126;
## Std. beta = -1.56, 95% CI [-3.56, 0.44])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.34, 95% CI [-3.01, 11.69], t(2038) = 1.16, p = 0.247; Std.
## beta = 0.54, 95% CI [-0.37, 1.45])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.67, 95% CI [-0.20, 11.53], t(2038) = 1.89, p = 0.058; Std.
## beta = 0.70, 95% CI [-0.02, 1.43])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.81, 95% CI [-6.33, 9.94], t(2038) = 0.44, p = 0.663; Std.
## beta = 0.22, 95% CI [-0.78, 1.23])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.50, 95% CI [-8.48, 7.48], t(2038) = -0.12, p = 0.903; Std.
## beta = -0.06, 95% CI [-1.05, 0.93])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-56.13, 36.88], t(2038) = -0.41, p = 0.685;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.37, 95% CI [-30.24, 25.49], t(2038) = -0.17, p = 0.867;
## Std. beta = -0.29, 95% CI [-3.75, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.37, 95% CI [-6.92, 4.19], t(2038) = -0.48, p = 0.629; Std.
## beta = -0.17, 95% CI [-0.86, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-36.21, 14.83], t(2038) = -0.82, p = 0.411;
## Std. beta = -1.33, 95% CI [-4.49, 1.84])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.36, 95% CI [-7.49, 12.20], t(2038) = 0.47, p = 0.639; Std.
## beta = 0.29, 95% CI [-0.93, 1.51])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.63, 95% CI [-6.35, 7.60], t(2038) = 0.18, p = 0.860; Std.
## beta = 0.08, 95% CI [-0.79, 0.94])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 6.03, 95% CI [-3.50, 15.56], t(2038) = 1.24, p = 0.215; Std.
## beta = 0.75, 95% CI [-0.43, 1.93])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 5.48, 95% CI [-0.27, 11.23], t(2038) = 1.87, p = 0.062; Std.
## beta = 0.68, 95% CI [-0.03, 1.39])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.95, 95% CI [-30.36, 74.27], t(2038) = 0.82, p = 0.411; Std.
## beta = 2.72, 95% CI [-3.77, 9.21])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-8.31, 1.96], t(2038) = -1.21, p = 0.226; Std.
## beta = -0.39, 95% CI [-1.03, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-7.40, 4.99], t(2038) = -0.38, p = 0.703; Std.
## beta = -0.15, 95% CI [-0.92, 0.62])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.87, 95% CI [-34.67, 16.92], t(2038) = -0.67, p = 0.500;
## Std. beta = -1.10, 95% CI [-4.30, 2.10])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-11.60, 8.94], t(2038) = -0.25, p = 0.800; Std.
## beta = -0.16, 95% CI [-1.44, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.00, 95% CI [-2.41, 6.40], t(2038) = 0.89, p = 0.374; Std.
## beta = 0.25, 95% CI [-0.30, 0.79])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.74, 95% CI [-8.04, 6.56], t(2038) = -0.20, p = 0.843; Std.
## beta = -0.09, 95% CI [-1.00, 0.81])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.85, 95% CI [-11.51, 3.80], t(2038) = -0.99, p = 0.324; Std.
## beta = -0.48, 95% CI [-1.43, 0.47])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.88, 95% CI [-4.09, 5.84], t(2038) = 0.35, p = 0.729; Std.
## beta = 0.11, 95% CI [-0.51, 0.72])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 9.28, 95% CI [-0.04, 18.59], t(2038) = 1.95, p = 0.051; Std.
## beta = 1.15, 95% CI [-4.80e-03, 2.31])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.09, 95% CI [-0.90, 11.07], t(2038) = 1.67, p = 0.096; Std.
## beta = 0.63, 95% CI [-0.11, 1.37])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.22, 4.85], t(2038) = -0.38, p = 0.701; Std.
## beta = -0.15, 95% CI [-0.90, 0.60])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.00, 95% CI [-6.16, 2.15], t(2038) = -0.95, p = 0.344; Std.
## beta = -0.25, 95% CI [-0.76, 0.27])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.53, 95% CI [-51.25, -9.81], t(2038) = -2.89, p = 0.004;
## Std. beta = -3.79, 95% CI [-6.36, -1.22])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-7.77, 10.64], t(2038) = 0.31, p = 0.760; Std.
## beta = 0.18, 95% CI [-0.96, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.47, 95% CI [-8.74, 17.68], t(2038) = 0.66, p = 0.507; Std.
## beta = 0.56, 95% CI [-1.08, 2.19])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.26, 95% CI [-14.97, 8.45], t(2038) = -0.55, p = 0.585; Std.
## beta = -0.40, 95% CI [-1.86, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*BC_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15056.8
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1489 -0.4976 -0.0123 0.4405 7.0939
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 142.57 11.940
## time_firstPFT 11.22 3.350 -0.31
## Residual 41.78 6.463
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 48.24185 3.49562 13.801
## time_firstPFT -7.05581 1.72868 -4.082
## BC_5yrPreCensor -9.20047 3.87083 -2.377
## site02R -3.75795 13.58134 -0.277
## site03R 23.78880 9.89866 2.403
## site04R -7.22234 9.28737 -0.778
## site05R -14.33979 7.78763 -1.841
## site06R 5.38086 9.65513 0.557
## site07R 2.75716 3.89022 0.709
## site09R -11.01810 9.47132 -1.163
## site101 16.72508 2.95576 5.658
## site102 4.93435 5.24389 0.941
## site103 -5.30302 2.67819 -1.980
## site104 -14.07530 5.56979 -2.527
## site105 -1.88542 2.96579 -0.636
## site106 -6.10619 3.55125 -1.719
## site107 6.69306 9.73488 0.688
## site108 -13.08684 7.85666 -1.666
## site10R -2.99147 13.49636 -0.222
## site11R -0.90711 5.73890 -0.158
## site12R -13.03969 9.50974 -1.371
## site13R -11.47777 7.33182 -1.565
## site14R -8.83687 15.00770 -0.589
## site15R -24.76347 13.62973 -1.817
## site16R -9.80613 5.91658 -1.657
## site17R 57.34356 13.65283 4.200
## site18R -6.73468 9.67534 -0.696
## site19R -10.26337 6.50515 -1.578
## site20R -5.65347 5.70400 -0.991
## site21R -12.56797 12.68816 -0.991
## site22R -12.64599 4.31471 -2.931
## site23R -21.41439 6.24157 -3.431
## site24R -1.11060 5.26256 -0.211
## site25R -8.51312 5.66635 -1.502
## site28R -17.53270 7.89892 -2.220
## site29R -2.22407 13.34833 -0.167
## site31R -1.83897 5.84820 -0.314
## site32R 1.77505 6.85251 0.259
## site33R -11.36376 6.72988 -1.689
## site34R -7.48066 5.15322 -1.452
## site35R -17.31250 8.02127 -2.158
## site36R 2.62823 5.96254 0.441
## site37R 0.91776 6.50436 0.141
## site38R -3.33715 4.50260 -0.741
## site39R 2.15744 13.40448 0.161
## site40R 1.95604 9.26809 0.211
## site41R -14.35549 7.71660 -1.860
## site42R -9.96084 4.37926 -2.275
## time_firstPFT:BC_5yrPreCensor 3.21863 1.92926 1.668
## time_firstPFT:site02R -34.14714 18.54095 -1.842
## time_firstPFT:site03R -0.69853 5.94769 -0.117
## time_firstPFT:site04R -1.12302 6.28500 -0.179
## time_firstPFT:site05R -3.00554 7.56676 -0.397
## time_firstPFT:site06R 2.89670 5.05035 0.574
## time_firstPFT:site07R -1.77263 1.54060 -1.151
## time_firstPFT:site09R 1.50817 4.23391 0.356
## time_firstPFT:site101 0.14098 1.30042 0.108
## time_firstPFT:site102 -0.26992 2.34354 -0.115
## time_firstPFT:site103 2.35303 1.20134 1.959
## time_firstPFT:site104 3.48492 3.77788 0.922
## time_firstPFT:site105 0.96251 1.33177 0.723
## time_firstPFT:site106 2.14359 1.71105 1.253
## time_firstPFT:site107 -12.16581 8.20426 -1.483
## time_firstPFT:site108 5.57007 3.58517 1.554
## time_firstPFT:site11R 5.13768 2.77405 1.852
## time_firstPFT:site12R 2.59243 4.10210 0.632
## time_firstPFT:site13R -0.07377 3.96310 -0.019
## time_firstPFT:site14R -10.29155 23.69141 -0.434
## time_firstPFT:site15R -1.64382 14.15960 -0.116
## time_firstPFT:site16R -0.62914 2.66264 -0.236
## time_firstPFT:site18R -10.13726 12.98537 -0.781
## time_firstPFT:site19R 3.89808 4.92054 0.792
## time_firstPFT:site20R 1.83219 3.46493 0.529
## time_firstPFT:site21R 5.31454 4.76089 1.116
## time_firstPFT:site22R 4.90441 2.81253 1.744
## time_firstPFT:site23R -0.07305 5.41833 -0.013
## time_firstPFT:site24R -2.37594 2.59776 -0.915
## time_firstPFT:site25R -1.18363 3.06269 -0.386
## time_firstPFT:site28R -9.32445 13.07176 -0.713
## time_firstPFT:site29R -2.06364 5.12960 -0.402
## time_firstPFT:site31R 1.87649 2.02107 0.928
## time_firstPFT:site32R -0.36636 3.59640 -0.102
## time_firstPFT:site33R -2.30602 3.83628 -0.601
## time_firstPFT:site34R 1.59434 2.44231 0.653
## time_firstPFT:site35R 9.80505 4.70616 2.083
## time_firstPFT:site36R 5.35018 2.96783 1.803
## time_firstPFT:site37R -1.34378 2.86028 -0.470
## time_firstPFT:site38R -1.53649 1.94091 -0.792
## time_firstPFT:site39R -28.76968 10.48012 -2.745
## time_firstPFT:site40R 2.81172 4.67412 0.602
## time_firstPFT:site41R 3.89395 6.66248 0.584
## time_firstPFT:site42R -2.45904 5.93519 -0.414##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.801
## Unadjusted ICC: 0.531report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## BC_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.34. The model's
## intercept, corresponding to time_firstPFT = 0, is at 48.24 (95% CI [41.39,
## 55.10], t(2068) = 13.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.06, 95% CI [-10.45, -3.67], t(2068) = -4.08, p < .001; Std. beta = -0.61,
## 95% CI [-0.76, -0.46])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -9.20, 95% CI [-16.79, -1.61], t(2068) = -2.38, p = 0.018; Std. beta = -0.07,
## 95% CI [-0.20, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-30.39, 22.88], t(2068) = -0.28, p = 0.782; Std. beta = -3.77,
## 95% CI [-7.16, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.79, 95% CI [4.38, 43.20], t(2068) = 2.40, p = 0.016; Std. beta = 1.55, 95%
## CI [0.28, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -7.22, 95% CI [-25.44, 10.99], t(2068) = -0.78, p = 0.437; Std. beta = -0.61,
## 95% CI [-2.05, 0.84])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.34, 95% CI [-29.61, 0.93], t(2068) = -1.84, p = 0.066; Std. beta = -1.28,
## 95% CI [-2.78, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.55, 24.32], t(2068) = 0.56, p = 0.577; Std. beta = 0.66,
## 95% CI [-0.70, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.87, 10.39], t(2068) = 0.71, p = 0.479; Std. beta = 5.31e-03,
## 95% CI [-0.49, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-29.59, 7.56], t(2068) = -1.16, p = 0.245; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.73, 95% CI [10.93, 22.52], t(2068) = 5.66, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-5.35, 15.22], t(2068) = 0.94, p = 0.347; Std. beta = 0.31, 95%
## CI [-0.38, 0.99])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.30, 95% CI [-10.56, -0.05], t(2068) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-0.48, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.08, 95% CI [-25.00, -3.15], t(2068) = -2.53, p = 0.012; Std. beta = -0.60,
## 95% CI [-1.49, 0.29])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.89, 95% CI [-7.70, 3.93], t(2068) = -0.64, p = 0.525; Std. beta = -0.03,
## 95% CI [-0.42, 0.37])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.11, 95% CI [-13.07, 0.86], t(2068) = -1.72, p = 0.086; Std. beta = -0.19,
## 95% CI [-0.66, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-12.40, 25.78], t(2068) = 0.69, p = 0.492; Std. beta = -0.80,
## 95% CI [-2.44, 0.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-28.49, 2.32], t(2068) = -1.67, p = 0.096; Std. beta = -0.32,
## 95% CI [-1.33, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-29.46, 23.48], t(2068) = -0.22, p = 0.825; Std. beta = -0.20,
## 95% CI [-2.00, 1.60])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-12.16, 10.35], t(2068) = -0.16, p = 0.874; Std. beta = 0.47,
## 95% CI [-0.32, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.69, 5.61], t(2068) = -1.37, p = 0.170; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.48, 95% CI [-25.86, 2.90], t(2068) = -1.57, p = 0.118; Std. beta = -0.79,
## 95% CI [-1.74, 0.17])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-38.27, 20.59], t(2068) = -0.59, p = 0.556; Std. beta = -1.66,
## 95% CI [-5.08, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.76, 95% CI [-51.49, 1.97], t(2068) = -1.82, p = 0.069; Std. beta = -1.85,
## 95% CI [-4.48, 0.77])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-21.41, 1.80], t(2068) = -1.66, p = 0.098; Std. beta = -0.73,
## 95% CI [-1.54, 0.07])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.34, 95% CI [30.57, 84.12], t(2068) = 4.20, p < .001; Std. beta = 3.90, 95%
## CI [2.08, 5.72])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-25.71, 12.24], t(2068) = -0.70, p = 0.486; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-23.02, 2.49], t(2068) = -1.58, p = 0.115; Std. beta = -0.30,
## 95% CI [-1.37, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-16.84, 5.53], t(2068) = -0.99, p = 0.322; Std. beta = -0.20,
## 95% CI [-1.02, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.57, 95% CI [-37.45, 12.31], t(2068) = -0.99, p = 0.322; Std. beta =
## -0.31, 95% CI [-1.89, 1.27])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.65, 95% CI [-21.11, -4.18], t(2068) = -2.93, p = 0.003; Std. beta = -0.36,
## 95% CI [-1.00, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.41, 95% CI [-33.65, -9.17], t(2068) = -3.43, p < .001; Std. beta = -1.46,
## 95% CI [-2.63, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-11.43, 9.21], t(2068) = -0.21, p = 0.833; Std. beta = -0.32,
## 95% CI [-1.02, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.51, 95% CI [-19.63, 2.60], t(2068) = -1.50, p = 0.133; Std. beta = -0.70,
## 95% CI [-1.47, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.53, 95% CI [-33.02, -2.04], t(2068) = -2.22, p = 0.027; Std. beta = -2.15,
## 95% CI [-4.71, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-28.40, 23.95], t(2068) = -0.17, p = 0.868; Std. beta = -0.36,
## 95% CI [-1.97, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.84, 95% CI [-13.31, 9.63], t(2068) = -0.31, p = 0.753; Std. beta = 0.07,
## 95% CI [-0.66, 0.79])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-11.66, 15.21], t(2068) = 0.26, p = 0.796; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-24.56, 1.83], t(2068) = -1.69, p = 0.091; Std. beta = -1.01,
## 95% CI [-2.01, -6.26e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-17.59, 2.63], t(2068) = -1.45, p = 0.147; Std. beta = -0.34,
## 95% CI [-1.04, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.31, 95% CI [-33.04, -1.58], t(2068) = -2.16, p = 0.031; Std. beta = -0.17,
## 95% CI [-1.29, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.06, 14.32], t(2068) = 0.44, p = 0.659; Std. beta = 0.73, 95%
## CI [-0.10, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-11.84, 13.67], t(2068) = 0.14, p = 0.888; Std. beta = -0.08,
## 95% CI [-0.92, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-12.17, 5.49], t(2068) = -0.74, p = 0.459; Std. beta = -0.38,
## 95% CI [-0.97, 0.20])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-24.13, 28.45], t(2068) = 0.16, p = 0.872; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.96, 95% CI [-16.22, 20.13], t(2068) = 0.21, p = 0.833; Std. beta = 0.42,
## 95% CI [-0.90, 1.75])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.36, 95% CI [-29.49, 0.78], t(2068) = -1.86, p = 0.063; Std. beta = -0.58,
## 95% CI [-1.94, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.96, 95% CI [-18.55, -1.37], t(2068) = -2.27, p = 0.023; Std. beta = -0.93,
## 95% CI [-2.02, 0.16])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 3.22, 95% CI [-0.56, 7.00], t(2068) =
## 1.67, p = 0.095; Std. beta = 0.10, 95% CI [-0.02, 0.21])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.15, 95% CI [-70.51, 2.21], t(2068) = -1.84, p = 0.066;
## Std. beta = -4.23, 95% CI [-8.73, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-12.36, 10.97], t(2068) = -0.12, p = 0.907;
## Std. beta = -0.09, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-13.45, 11.20], t(2068) = -0.18, p = 0.858;
## Std. beta = -0.14, 95% CI [-1.67, 1.39])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-17.84, 11.83], t(2068) = -0.40, p = 0.691;
## Std. beta = -0.37, 95% CI [-2.21, 1.47])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-7.01, 12.80], t(2068) = 0.57, p = 0.566; Std.
## beta = 0.36, 95% CI [-0.87, 1.59])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.77, 95% CI [-4.79, 1.25], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.22, 95% CI [-0.59, 0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-6.79, 9.81], t(2068) = 0.36, p = 0.722; Std.
## beta = 0.19, 95% CI [-0.84, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-2.41, 2.69], t(2068) = 0.11, p = 0.914; Std.
## beta = 0.02, 95% CI [-0.30, 0.33])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-4.87, 4.33], t(2068) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.60, 0.54])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.35, 95% CI [-2.92e-03, 4.71], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.29, 95% CI [-3.63e-04, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.48, 95% CI [-3.92, 10.89], t(2068) = 0.92, p = 0.356; Std.
## beta = 0.43, 95% CI [-0.49, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-1.65, 3.57], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.12, 95% CI [-0.20, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.21, 5.50], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.27, 95% CI [-0.15, 0.68])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.17, 95% CI [-28.26, 3.92], t(2068) = -1.48, p = 0.138;
## Std. beta = -1.51, 95% CI [-3.50, 0.49])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.57, 95% CI [-1.46, 12.60], t(2068) = 1.55, p = 0.120; Std.
## beta = 0.69, 95% CI [-0.18, 1.56])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-0.30, 10.58], t(2068) = 1.85, p = 0.064; Std.
## beta = 0.64, 95% CI [-0.04, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.59, 95% CI [-5.45, 10.64], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.32, 95% CI [-0.68, 1.32])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-7.85, 7.70], t(2068) = -0.02, p = 0.985; Std.
## beta = -9.13e-03, 95% CI [-0.97, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.75, 36.17], t(2068) = -0.43, p = 0.664;
## Std. beta = -1.27, 95% CI [-7.03, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.41, 26.12], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.64, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-5.85, 4.59], t(2068) = -0.24, p = 0.813; Std.
## beta = -0.08, 95% CI [-0.72, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.14, 95% CI [-35.60, 15.33], t(2068) = -0.78, p = 0.435;
## Std. beta = -1.26, 95% CI [-4.41, 1.90])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-5.75, 13.55], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.48, 95% CI [-0.71, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-4.96, 8.63], t(2068) = 0.53, p = 0.597; Std.
## beta = 0.23, 95% CI [-0.61, 1.07])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-4.02, 14.65], t(2068) = 1.12, p = 0.264; Std.
## beta = 0.66, 95% CI [-0.50, 1.81])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.61, 10.42], t(2068) = 1.74, p = 0.081; Std.
## beta = 0.61, 95% CI [-0.08, 1.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-10.70, 10.55], t(2068) = -0.01, p = 0.989;
## Std. beta = -9.04e-03, 95% CI [-1.33, 1.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-7.47, 2.72], t(2068) = -0.91, p = 0.361; Std.
## beta = -0.29, 95% CI [-0.93, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.19, 4.82], t(2068) = -0.39, p = 0.699; Std.
## beta = -0.15, 95% CI [-0.89, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-34.96, 16.31], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-12.12, 8.00], t(2068) = -0.40, p = 0.688; Std.
## beta = -0.26, 95% CI [-1.50, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.09, 5.84], t(2068) = 0.93, p = 0.353; Std.
## beta = 0.23, 95% CI [-0.26, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-7.42, 6.69], t(2068) = -0.10, p = 0.919; Std.
## beta = -0.05, 95% CI [-0.92, 0.83])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-9.83, 5.22], t(2068) = -0.60, p = 0.548; Std.
## beta = -0.29, 95% CI [-1.22, 0.65])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2068) = 0.65, p = 0.514; Std.
## beta = 0.20, 95% CI [-0.40, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.81, 95% CI [0.58, 19.03], t(2068) = 2.08, p = 0.037; Std.
## beta = 1.21, 95% CI [0.07, 2.36])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.47, 11.17], t(2068) = 1.80, p = 0.072; Std.
## beta = 0.66, 95% CI [-0.06, 1.38])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.95, 4.27], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.17, 95% CI [-0.86, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.34, 2.27], t(2068) = -0.79, p = 0.429; Std.
## beta = -0.19, 95% CI [-0.66, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.77, 95% CI [-49.32, -8.22], t(2068) = -2.75, p = 0.006;
## Std. beta = -3.56, 95% CI [-6.11, -1.02])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.35, 11.98], t(2068) = 0.60, p = 0.548; Std.
## beta = 0.35, 95% CI [-0.79, 1.48])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-9.17, 16.96], t(2068) = 0.58, p = 0.559; Std.
## beta = 0.48, 95% CI [-1.14, 2.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-14.10, 9.18], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.30, 95% CI [-1.75, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## BC_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to BC_5yrPreCensor = 0, is at 48.24 (95% CI [41.39, 55.10],
## t(2068) = 13.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.06, 95% CI [-10.45, -3.67], t(2068) = -4.08, p < .001; Std. beta = -0.61,
## 95% CI [-0.76, -0.46])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -9.20, 95% CI [-16.79, -1.61], t(2068) = -2.38, p = 0.018; Std. beta = -0.07,
## 95% CI [-0.20, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-30.39, 22.88], t(2068) = -0.28, p = 0.782; Std. beta = -3.77,
## 95% CI [-7.16, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.79, 95% CI [4.38, 43.20], t(2068) = 2.40, p = 0.016; Std. beta = 1.55, 95%
## CI [0.28, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -7.22, 95% CI [-25.44, 10.99], t(2068) = -0.78, p = 0.437; Std. beta = -0.61,
## 95% CI [-2.05, 0.84])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.34, 95% CI [-29.61, 0.93], t(2068) = -1.84, p = 0.066; Std. beta = -1.28,
## 95% CI [-2.78, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.55, 24.32], t(2068) = 0.56, p = 0.577; Std. beta = 0.66,
## 95% CI [-0.70, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.87, 10.39], t(2068) = 0.71, p = 0.479; Std. beta = 5.31e-03,
## 95% CI [-0.49, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-29.59, 7.56], t(2068) = -1.16, p = 0.245; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.73, 95% CI [10.93, 22.52], t(2068) = 5.66, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-5.35, 15.22], t(2068) = 0.94, p = 0.347; Std. beta = 0.31, 95%
## CI [-0.38, 0.99])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.30, 95% CI [-10.56, -0.05], t(2068) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-0.48, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.08, 95% CI [-25.00, -3.15], t(2068) = -2.53, p = 0.012; Std. beta = -0.60,
## 95% CI [-1.49, 0.29])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.89, 95% CI [-7.70, 3.93], t(2068) = -0.64, p = 0.525; Std. beta = -0.03,
## 95% CI [-0.42, 0.37])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.11, 95% CI [-13.07, 0.86], t(2068) = -1.72, p = 0.086; Std. beta = -0.19,
## 95% CI [-0.66, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-12.40, 25.78], t(2068) = 0.69, p = 0.492; Std. beta = -0.80,
## 95% CI [-2.44, 0.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-28.49, 2.32], t(2068) = -1.67, p = 0.096; Std. beta = -0.32,
## 95% CI [-1.33, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-29.46, 23.48], t(2068) = -0.22, p = 0.825; Std. beta = -0.20,
## 95% CI [-2.00, 1.60])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-12.16, 10.35], t(2068) = -0.16, p = 0.874; Std. beta = 0.47,
## 95% CI [-0.32, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.69, 5.61], t(2068) = -1.37, p = 0.170; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.48, 95% CI [-25.86, 2.90], t(2068) = -1.57, p = 0.118; Std. beta = -0.79,
## 95% CI [-1.74, 0.17])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-38.27, 20.59], t(2068) = -0.59, p = 0.556; Std. beta = -1.66,
## 95% CI [-5.08, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.76, 95% CI [-51.49, 1.97], t(2068) = -1.82, p = 0.069; Std. beta = -1.85,
## 95% CI [-4.48, 0.77])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-21.41, 1.80], t(2068) = -1.66, p = 0.098; Std. beta = -0.73,
## 95% CI [-1.54, 0.07])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.34, 95% CI [30.57, 84.12], t(2068) = 4.20, p < .001; Std. beta = 3.90, 95%
## CI [2.08, 5.72])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-25.71, 12.24], t(2068) = -0.70, p = 0.486; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-23.02, 2.49], t(2068) = -1.58, p = 0.115; Std. beta = -0.30,
## 95% CI [-1.37, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-16.84, 5.53], t(2068) = -0.99, p = 0.322; Std. beta = -0.20,
## 95% CI [-1.02, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.57, 95% CI [-37.45, 12.31], t(2068) = -0.99, p = 0.322; Std. beta =
## -0.31, 95% CI [-1.89, 1.27])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.65, 95% CI [-21.11, -4.18], t(2068) = -2.93, p = 0.003; Std. beta = -0.36,
## 95% CI [-1.00, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.41, 95% CI [-33.65, -9.17], t(2068) = -3.43, p < .001; Std. beta = -1.46,
## 95% CI [-2.63, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-11.43, 9.21], t(2068) = -0.21, p = 0.833; Std. beta = -0.32,
## 95% CI [-1.02, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.51, 95% CI [-19.63, 2.60], t(2068) = -1.50, p = 0.133; Std. beta = -0.70,
## 95% CI [-1.47, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.53, 95% CI [-33.02, -2.04], t(2068) = -2.22, p = 0.027; Std. beta = -2.15,
## 95% CI [-4.71, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-28.40, 23.95], t(2068) = -0.17, p = 0.868; Std. beta = -0.36,
## 95% CI [-1.97, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.84, 95% CI [-13.31, 9.63], t(2068) = -0.31, p = 0.753; Std. beta = 0.07,
## 95% CI [-0.66, 0.79])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-11.66, 15.21], t(2068) = 0.26, p = 0.796; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-24.56, 1.83], t(2068) = -1.69, p = 0.091; Std. beta = -1.01,
## 95% CI [-2.01, -6.26e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-17.59, 2.63], t(2068) = -1.45, p = 0.147; Std. beta = -0.34,
## 95% CI [-1.04, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.31, 95% CI [-33.04, -1.58], t(2068) = -2.16, p = 0.031; Std. beta = -0.17,
## 95% CI [-1.29, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.06, 14.32], t(2068) = 0.44, p = 0.659; Std. beta = 0.73, 95%
## CI [-0.10, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-11.84, 13.67], t(2068) = 0.14, p = 0.888; Std. beta = -0.08,
## 95% CI [-0.92, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-12.17, 5.49], t(2068) = -0.74, p = 0.459; Std. beta = -0.38,
## 95% CI [-0.97, 0.20])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-24.13, 28.45], t(2068) = 0.16, p = 0.872; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.96, 95% CI [-16.22, 20.13], t(2068) = 0.21, p = 0.833; Std. beta = 0.42,
## 95% CI [-0.90, 1.75])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.36, 95% CI [-29.49, 0.78], t(2068) = -1.86, p = 0.063; Std. beta = -0.58,
## 95% CI [-1.94, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.96, 95% CI [-18.55, -1.37], t(2068) = -2.27, p = 0.023; Std. beta = -0.93,
## 95% CI [-2.02, 0.16])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 3.22, 95% CI [-0.56, 7.00], t(2068) =
## 1.67, p = 0.095; Std. beta = 0.10, 95% CI [-0.02, 0.21])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.15, 95% CI [-70.51, 2.21], t(2068) = -1.84, p = 0.066;
## Std. beta = -4.23, 95% CI [-8.73, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-12.36, 10.97], t(2068) = -0.12, p = 0.907;
## Std. beta = -0.09, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-13.45, 11.20], t(2068) = -0.18, p = 0.858;
## Std. beta = -0.14, 95% CI [-1.67, 1.39])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-17.84, 11.83], t(2068) = -0.40, p = 0.691;
## Std. beta = -0.37, 95% CI [-2.21, 1.47])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-7.01, 12.80], t(2068) = 0.57, p = 0.566; Std.
## beta = 0.36, 95% CI [-0.87, 1.59])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.77, 95% CI [-4.79, 1.25], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.22, 95% CI [-0.59, 0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-6.79, 9.81], t(2068) = 0.36, p = 0.722; Std.
## beta = 0.19, 95% CI [-0.84, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-2.41, 2.69], t(2068) = 0.11, p = 0.914; Std.
## beta = 0.02, 95% CI [-0.30, 0.33])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-4.87, 4.33], t(2068) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.60, 0.54])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.35, 95% CI [-2.92e-03, 4.71], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.29, 95% CI [-3.63e-04, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.48, 95% CI [-3.92, 10.89], t(2068) = 0.92, p = 0.356; Std.
## beta = 0.43, 95% CI [-0.49, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-1.65, 3.57], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.12, 95% CI [-0.20, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.21, 5.50], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.27, 95% CI [-0.15, 0.68])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.17, 95% CI [-28.26, 3.92], t(2068) = -1.48, p = 0.138;
## Std. beta = -1.51, 95% CI [-3.50, 0.49])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.57, 95% CI [-1.46, 12.60], t(2068) = 1.55, p = 0.120; Std.
## beta = 0.69, 95% CI [-0.18, 1.56])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-0.30, 10.58], t(2068) = 1.85, p = 0.064; Std.
## beta = 0.64, 95% CI [-0.04, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.59, 95% CI [-5.45, 10.64], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.32, 95% CI [-0.68, 1.32])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-7.85, 7.70], t(2068) = -0.02, p = 0.985; Std.
## beta = -9.13e-03, 95% CI [-0.97, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.75, 36.17], t(2068) = -0.43, p = 0.664;
## Std. beta = -1.27, 95% CI [-7.03, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.41, 26.12], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.64, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-5.85, 4.59], t(2068) = -0.24, p = 0.813; Std.
## beta = -0.08, 95% CI [-0.72, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.14, 95% CI [-35.60, 15.33], t(2068) = -0.78, p = 0.435;
## Std. beta = -1.26, 95% CI [-4.41, 1.90])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-5.75, 13.55], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.48, 95% CI [-0.71, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-4.96, 8.63], t(2068) = 0.53, p = 0.597; Std.
## beta = 0.23, 95% CI [-0.61, 1.07])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-4.02, 14.65], t(2068) = 1.12, p = 0.264; Std.
## beta = 0.66, 95% CI [-0.50, 1.81])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.61, 10.42], t(2068) = 1.74, p = 0.081; Std.
## beta = 0.61, 95% CI [-0.08, 1.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-10.70, 10.55], t(2068) = -0.01, p = 0.989;
## Std. beta = -9.04e-03, 95% CI [-1.33, 1.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-7.47, 2.72], t(2068) = -0.91, p = 0.361; Std.
## beta = -0.29, 95% CI [-0.93, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.19, 4.82], t(2068) = -0.39, p = 0.699; Std.
## beta = -0.15, 95% CI [-0.89, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-34.96, 16.31], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-12.12, 8.00], t(2068) = -0.40, p = 0.688; Std.
## beta = -0.26, 95% CI [-1.50, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.09, 5.84], t(2068) = 0.93, p = 0.353; Std.
## beta = 0.23, 95% CI [-0.26, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-7.42, 6.69], t(2068) = -0.10, p = 0.919; Std.
## beta = -0.05, 95% CI [-0.92, 0.83])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-9.83, 5.22], t(2068) = -0.60, p = 0.548; Std.
## beta = -0.29, 95% CI [-1.22, 0.65])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2068) = 0.65, p = 0.514; Std.
## beta = 0.20, 95% CI [-0.40, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.81, 95% CI [0.58, 19.03], t(2068) = 2.08, p = 0.037; Std.
## beta = 1.21, 95% CI [0.07, 2.36])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.47, 11.17], t(2068) = 1.80, p = 0.072; Std.
## beta = 0.66, 95% CI [-0.06, 1.38])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.95, 4.27], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.17, 95% CI [-0.86, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.34, 2.27], t(2068) = -0.79, p = 0.429; Std.
## beta = -0.19, 95% CI [-0.66, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.77, 95% CI [-49.32, -8.22], t(2068) = -2.75, p = 0.006;
## Std. beta = -3.56, 95% CI [-6.11, -1.02])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.35, 11.98], t(2068) = 0.60, p = 0.548; Std.
## beta = 0.35, 95% CI [-0.79, 1.48])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-9.17, 16.96], t(2068) = 0.58, p = 0.559; Std.
## beta = 0.48, 95% CI [-1.14, 2.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-14.10, 9.18], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.30, 95% CI [-1.75, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.34. The model's intercept, corresponding to site =
## Simmons, is at 48.24 (95% CI [41.39, 55.10], t(2068) = 13.80, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.06, 95% CI [-10.45, -3.67], t(2068) = -4.08, p < .001; Std. beta = -0.61,
## 95% CI [-0.76, -0.46])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -9.20, 95% CI [-16.79, -1.61], t(2068) = -2.38, p = 0.018; Std. beta = -0.07,
## 95% CI [-0.20, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-30.39, 22.88], t(2068) = -0.28, p = 0.782; Std. beta = -3.77,
## 95% CI [-7.16, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.79, 95% CI [4.38, 43.20], t(2068) = 2.40, p = 0.016; Std. beta = 1.55, 95%
## CI [0.28, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -7.22, 95% CI [-25.44, 10.99], t(2068) = -0.78, p = 0.437; Std. beta = -0.61,
## 95% CI [-2.05, 0.84])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.34, 95% CI [-29.61, 0.93], t(2068) = -1.84, p = 0.066; Std. beta = -1.28,
## 95% CI [-2.78, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.55, 24.32], t(2068) = 0.56, p = 0.577; Std. beta = 0.66,
## 95% CI [-0.70, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.87, 10.39], t(2068) = 0.71, p = 0.479; Std. beta = 5.31e-03,
## 95% CI [-0.49, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-29.59, 7.56], t(2068) = -1.16, p = 0.245; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.73, 95% CI [10.93, 22.52], t(2068) = 5.66, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-5.35, 15.22], t(2068) = 0.94, p = 0.347; Std. beta = 0.31, 95%
## CI [-0.38, 0.99])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.30, 95% CI [-10.56, -0.05], t(2068) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-0.48, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.08, 95% CI [-25.00, -3.15], t(2068) = -2.53, p = 0.012; Std. beta = -0.60,
## 95% CI [-1.49, 0.29])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.89, 95% CI [-7.70, 3.93], t(2068) = -0.64, p = 0.525; Std. beta = -0.03,
## 95% CI [-0.42, 0.37])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.11, 95% CI [-13.07, 0.86], t(2068) = -1.72, p = 0.086; Std. beta = -0.19,
## 95% CI [-0.66, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-12.40, 25.78], t(2068) = 0.69, p = 0.492; Std. beta = -0.80,
## 95% CI [-2.44, 0.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-28.49, 2.32], t(2068) = -1.67, p = 0.096; Std. beta = -0.32,
## 95% CI [-1.33, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-29.46, 23.48], t(2068) = -0.22, p = 0.825; Std. beta = -0.20,
## 95% CI [-2.00, 1.60])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-12.16, 10.35], t(2068) = -0.16, p = 0.874; Std. beta = 0.47,
## 95% CI [-0.32, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.69, 5.61], t(2068) = -1.37, p = 0.170; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.48, 95% CI [-25.86, 2.90], t(2068) = -1.57, p = 0.118; Std. beta = -0.79,
## 95% CI [-1.74, 0.17])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-38.27, 20.59], t(2068) = -0.59, p = 0.556; Std. beta = -1.66,
## 95% CI [-5.08, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.76, 95% CI [-51.49, 1.97], t(2068) = -1.82, p = 0.069; Std. beta = -1.85,
## 95% CI [-4.48, 0.77])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-21.41, 1.80], t(2068) = -1.66, p = 0.098; Std. beta = -0.73,
## 95% CI [-1.54, 0.07])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.34, 95% CI [30.57, 84.12], t(2068) = 4.20, p < .001; Std. beta = 3.90, 95%
## CI [2.08, 5.72])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-25.71, 12.24], t(2068) = -0.70, p = 0.486; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-23.02, 2.49], t(2068) = -1.58, p = 0.115; Std. beta = -0.30,
## 95% CI [-1.37, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-16.84, 5.53], t(2068) = -0.99, p = 0.322; Std. beta = -0.20,
## 95% CI [-1.02, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.57, 95% CI [-37.45, 12.31], t(2068) = -0.99, p = 0.322; Std. beta =
## -0.31, 95% CI [-1.89, 1.27])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.65, 95% CI [-21.11, -4.18], t(2068) = -2.93, p = 0.003; Std. beta = -0.36,
## 95% CI [-1.00, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.41, 95% CI [-33.65, -9.17], t(2068) = -3.43, p < .001; Std. beta = -1.46,
## 95% CI [-2.63, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-11.43, 9.21], t(2068) = -0.21, p = 0.833; Std. beta = -0.32,
## 95% CI [-1.02, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.51, 95% CI [-19.63, 2.60], t(2068) = -1.50, p = 0.133; Std. beta = -0.70,
## 95% CI [-1.47, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.53, 95% CI [-33.02, -2.04], t(2068) = -2.22, p = 0.027; Std. beta = -2.15,
## 95% CI [-4.71, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-28.40, 23.95], t(2068) = -0.17, p = 0.868; Std. beta = -0.36,
## 95% CI [-1.97, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.84, 95% CI [-13.31, 9.63], t(2068) = -0.31, p = 0.753; Std. beta = 0.07,
## 95% CI [-0.66, 0.79])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-11.66, 15.21], t(2068) = 0.26, p = 0.796; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-24.56, 1.83], t(2068) = -1.69, p = 0.091; Std. beta = -1.01,
## 95% CI [-2.01, -6.26e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-17.59, 2.63], t(2068) = -1.45, p = 0.147; Std. beta = -0.34,
## 95% CI [-1.04, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.31, 95% CI [-33.04, -1.58], t(2068) = -2.16, p = 0.031; Std. beta = -0.17,
## 95% CI [-1.29, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.06, 14.32], t(2068) = 0.44, p = 0.659; Std. beta = 0.73, 95%
## CI [-0.10, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-11.84, 13.67], t(2068) = 0.14, p = 0.888; Std. beta = -0.08,
## 95% CI [-0.92, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-12.17, 5.49], t(2068) = -0.74, p = 0.459; Std. beta = -0.38,
## 95% CI [-0.97, 0.20])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-24.13, 28.45], t(2068) = 0.16, p = 0.872; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.96, 95% CI [-16.22, 20.13], t(2068) = 0.21, p = 0.833; Std. beta = 0.42,
## 95% CI [-0.90, 1.75])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.36, 95% CI [-29.49, 0.78], t(2068) = -1.86, p = 0.063; Std. beta = -0.58,
## 95% CI [-1.94, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.96, 95% CI [-18.55, -1.37], t(2068) = -2.27, p = 0.023; Std. beta = -0.93,
## 95% CI [-2.02, 0.16])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 3.22, 95% CI [-0.56, 7.00], t(2068) =
## 1.67, p = 0.095; Std. beta = 0.10, 95% CI [-0.02, 0.21])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.15, 95% CI [-70.51, 2.21], t(2068) = -1.84, p = 0.066;
## Std. beta = -4.23, 95% CI [-8.73, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-12.36, 10.97], t(2068) = -0.12, p = 0.907;
## Std. beta = -0.09, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-13.45, 11.20], t(2068) = -0.18, p = 0.858;
## Std. beta = -0.14, 95% CI [-1.67, 1.39])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-17.84, 11.83], t(2068) = -0.40, p = 0.691;
## Std. beta = -0.37, 95% CI [-2.21, 1.47])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-7.01, 12.80], t(2068) = 0.57, p = 0.566; Std.
## beta = 0.36, 95% CI [-0.87, 1.59])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.77, 95% CI [-4.79, 1.25], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.22, 95% CI [-0.59, 0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-6.79, 9.81], t(2068) = 0.36, p = 0.722; Std.
## beta = 0.19, 95% CI [-0.84, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-2.41, 2.69], t(2068) = 0.11, p = 0.914; Std.
## beta = 0.02, 95% CI [-0.30, 0.33])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-4.87, 4.33], t(2068) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.60, 0.54])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.35, 95% CI [-2.92e-03, 4.71], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.29, 95% CI [-3.63e-04, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.48, 95% CI [-3.92, 10.89], t(2068) = 0.92, p = 0.356; Std.
## beta = 0.43, 95% CI [-0.49, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-1.65, 3.57], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.12, 95% CI [-0.20, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.21, 5.50], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.27, 95% CI [-0.15, 0.68])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.17, 95% CI [-28.26, 3.92], t(2068) = -1.48, p = 0.138;
## Std. beta = -1.51, 95% CI [-3.50, 0.49])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.57, 95% CI [-1.46, 12.60], t(2068) = 1.55, p = 0.120; Std.
## beta = 0.69, 95% CI [-0.18, 1.56])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-0.30, 10.58], t(2068) = 1.85, p = 0.064; Std.
## beta = 0.64, 95% CI [-0.04, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.59, 95% CI [-5.45, 10.64], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.32, 95% CI [-0.68, 1.32])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-7.85, 7.70], t(2068) = -0.02, p = 0.985; Std.
## beta = -9.13e-03, 95% CI [-0.97, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.75, 36.17], t(2068) = -0.43, p = 0.664;
## Std. beta = -1.27, 95% CI [-7.03, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.41, 26.12], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.64, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-5.85, 4.59], t(2068) = -0.24, p = 0.813; Std.
## beta = -0.08, 95% CI [-0.72, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.14, 95% CI [-35.60, 15.33], t(2068) = -0.78, p = 0.435;
## Std. beta = -1.26, 95% CI [-4.41, 1.90])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-5.75, 13.55], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.48, 95% CI [-0.71, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-4.96, 8.63], t(2068) = 0.53, p = 0.597; Std.
## beta = 0.23, 95% CI [-0.61, 1.07])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-4.02, 14.65], t(2068) = 1.12, p = 0.264; Std.
## beta = 0.66, 95% CI [-0.50, 1.81])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.61, 10.42], t(2068) = 1.74, p = 0.081; Std.
## beta = 0.61, 95% CI [-0.08, 1.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-10.70, 10.55], t(2068) = -0.01, p = 0.989;
## Std. beta = -9.04e-03, 95% CI [-1.33, 1.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-7.47, 2.72], t(2068) = -0.91, p = 0.361; Std.
## beta = -0.29, 95% CI [-0.93, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.19, 4.82], t(2068) = -0.39, p = 0.699; Std.
## beta = -0.15, 95% CI [-0.89, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-34.96, 16.31], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-12.12, 8.00], t(2068) = -0.40, p = 0.688; Std.
## beta = -0.26, 95% CI [-1.50, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.09, 5.84], t(2068) = 0.93, p = 0.353; Std.
## beta = 0.23, 95% CI [-0.26, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-7.42, 6.69], t(2068) = -0.10, p = 0.919; Std.
## beta = -0.05, 95% CI [-0.92, 0.83])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-9.83, 5.22], t(2068) = -0.60, p = 0.548; Std.
## beta = -0.29, 95% CI [-1.22, 0.65])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2068) = 0.65, p = 0.514; Std.
## beta = 0.20, 95% CI [-0.40, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.81, 95% CI [0.58, 19.03], t(2068) = 2.08, p = 0.037; Std.
## beta = 1.21, 95% CI [0.07, 2.36])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.47, 11.17], t(2068) = 1.80, p = 0.072; Std.
## beta = 0.66, 95% CI [-0.06, 1.38])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.95, 4.27], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.17, 95% CI [-0.86, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.34, 2.27], t(2068) = -0.79, p = 0.429; Std.
## beta = -0.19, 95% CI [-0.66, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.77, 95% CI [-49.32, -8.22], t(2068) = -2.75, p = 0.006;
## Std. beta = -3.56, 95% CI [-6.11, -1.02])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.35, 11.98], t(2068) = 0.60, p = 0.548; Std.
## beta = 0.35, 95% CI [-0.79, 1.48])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-9.17, 16.96], t(2068) = 0.58, p = 0.559; Std.
## beta = 0.48, 95% CI [-1.14, 2.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-14.10, 9.18], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.30, 95% CI [-1.75, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to cohort = CARE-PF, is at 48.24 (95% CI [41.39, 55.10], t(2068)
## = 13.80, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -7.06, 95% CI [-10.45, -3.67], t(2068) = -4.08, p < .001; Std. beta = -0.61,
## 95% CI [-0.76, -0.46])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -9.20, 95% CI [-16.79, -1.61], t(2068) = -2.38, p = 0.018; Std. beta = -0.07,
## 95% CI [-0.20, 0.06])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -3.76, 95% CI [-30.39, 22.88], t(2068) = -0.28, p = 0.782; Std. beta = -3.77,
## 95% CI [-7.16, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 23.79, 95% CI [4.38, 43.20], t(2068) = 2.40, p = 0.016; Std. beta = 1.55, 95%
## CI [0.28, 2.81])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -7.22, 95% CI [-25.44, 10.99], t(2068) = -0.78, p = 0.437; Std. beta = -0.61,
## 95% CI [-2.05, 0.84])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.34, 95% CI [-29.61, 0.93], t(2068) = -1.84, p = 0.066; Std. beta = -1.28,
## 95% CI [-2.78, 0.21])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 5.38, 95% CI [-13.55, 24.32], t(2068) = 0.56, p = 0.577; Std. beta = 0.66,
## 95% CI [-0.70, 2.03])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.76, 95% CI [-4.87, 10.39], t(2068) = 0.71, p = 0.479; Std. beta = 5.31e-03,
## 95% CI [-0.49, 0.50])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.02, 95% CI [-29.59, 7.56], t(2068) = -1.16, p = 0.245; Std. beta = -0.59,
## 95% CI [-1.87, 0.68])
## - The effect of site [101] is statistically significant and positive (beta =
## 16.73, 95% CI [10.93, 22.52], t(2068) = 5.66, p < .001; Std. beta = 1.15, 95%
## CI [0.76, 1.55])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.93, 95% CI [-5.35, 15.22], t(2068) = 0.94, p = 0.347; Std. beta = 0.31, 95%
## CI [-0.38, 0.99])
## - The effect of site [103] is statistically significant and negative (beta =
## -5.30, 95% CI [-10.56, -0.05], t(2068) = -1.98, p = 0.048; Std. beta = -0.12,
## 95% CI [-0.48, 0.24])
## - The effect of site [104] is statistically significant and negative (beta =
## -14.08, 95% CI [-25.00, -3.15], t(2068) = -2.53, p = 0.012; Std. beta = -0.60,
## 95% CI [-1.49, 0.29])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -1.89, 95% CI [-7.70, 3.93], t(2068) = -0.64, p = 0.525; Std. beta = -0.03,
## 95% CI [-0.42, 0.37])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -6.11, 95% CI [-13.07, 0.86], t(2068) = -1.72, p = 0.086; Std. beta = -0.19,
## 95% CI [-0.66, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 6.69, 95% CI [-12.40, 25.78], t(2068) = 0.69, p = 0.492; Std. beta = -0.80,
## 95% CI [-2.44, 0.84])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -13.09, 95% CI [-28.49, 2.32], t(2068) = -1.67, p = 0.096; Std. beta = -0.32,
## 95% CI [-1.33, 0.69])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-29.46, 23.48], t(2068) = -0.22, p = 0.825; Std. beta = -0.20,
## 95% CI [-2.00, 1.60])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-12.16, 10.35], t(2068) = -0.16, p = 0.874; Std. beta = 0.47,
## 95% CI [-0.32, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -13.04, 95% CI [-31.69, 5.61], t(2068) = -1.37, p = 0.170; Std. beta = -0.62,
## 95% CI [-1.91, 0.67])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.48, 95% CI [-25.86, 2.90], t(2068) = -1.57, p = 0.118; Std. beta = -0.79,
## 95% CI [-1.74, 0.17])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.84, 95% CI [-38.27, 20.59], t(2068) = -0.59, p = 0.556; Std. beta = -1.66,
## 95% CI [-5.08, 1.76])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -24.76, 95% CI [-51.49, 1.97], t(2068) = -1.82, p = 0.069; Std. beta = -1.85,
## 95% CI [-4.48, 0.77])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.81, 95% CI [-21.41, 1.80], t(2068) = -1.66, p = 0.098; Std. beta = -0.73,
## 95% CI [-1.54, 0.07])
## - The effect of site [17R] is statistically significant and positive (beta =
## 57.34, 95% CI [30.57, 84.12], t(2068) = 4.20, p < .001; Std. beta = 3.90, 95%
## CI [2.08, 5.72])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -6.73, 95% CI [-25.71, 12.24], t(2068) = -0.70, p = 0.486; Std. beta = -1.50,
## 95% CI [-4.02, 1.02])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-23.02, 2.49], t(2068) = -1.58, p = 0.115; Std. beta = -0.30,
## 95% CI [-1.37, 0.78])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.65, 95% CI [-16.84, 5.53], t(2068) = -0.99, p = 0.322; Std. beta = -0.20,
## 95% CI [-1.02, 0.63])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.57, 95% CI [-37.45, 12.31], t(2068) = -0.99, p = 0.322; Std. beta =
## -0.31, 95% CI [-1.89, 1.27])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.65, 95% CI [-21.11, -4.18], t(2068) = -2.93, p = 0.003; Std. beta = -0.36,
## 95% CI [-1.00, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -21.41, 95% CI [-33.65, -9.17], t(2068) = -3.43, p < .001; Std. beta = -1.46,
## 95% CI [-2.63, -0.29])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.11, 95% CI [-11.43, 9.21], t(2068) = -0.21, p = 0.833; Std. beta = -0.32,
## 95% CI [-1.02, 0.38])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.51, 95% CI [-19.63, 2.60], t(2068) = -1.50, p = 0.133; Std. beta = -0.70,
## 95% CI [-1.47, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.53, 95% CI [-33.02, -2.04], t(2068) = -2.22, p = 0.027; Std. beta = -2.15,
## 95% CI [-4.71, 0.41])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -2.22, 95% CI [-28.40, 23.95], t(2068) = -0.17, p = 0.868; Std. beta = -0.36,
## 95% CI [-1.97, 1.25])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -1.84, 95% CI [-13.31, 9.63], t(2068) = -0.31, p = 0.753; Std. beta = 0.07,
## 95% CI [-0.66, 0.79])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 1.78, 95% CI [-11.66, 15.21], t(2068) = 0.26, p = 0.796; Std. beta = 0.08,
## 95% CI [-0.86, 1.02])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.36, 95% CI [-24.56, 1.83], t(2068) = -1.69, p = 0.091; Std. beta = -1.01,
## 95% CI [-2.01, -6.26e-03])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.48, 95% CI [-17.59, 2.63], t(2068) = -1.45, p = 0.147; Std. beta = -0.34,
## 95% CI [-1.04, 0.35])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.31, 95% CI [-33.04, -1.58], t(2068) = -2.16, p = 0.031; Std. beta = -0.17,
## 95% CI [-1.29, 0.95])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.63, 95% CI [-9.06, 14.32], t(2068) = 0.44, p = 0.659; Std. beta = 0.73, 95%
## CI [-0.10, 1.56])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.92, 95% CI [-11.84, 13.67], t(2068) = 0.14, p = 0.888; Std. beta = -0.08,
## 95% CI [-0.92, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -3.34, 95% CI [-12.17, 5.49], t(2068) = -0.74, p = 0.459; Std. beta = -0.38,
## 95% CI [-0.97, 0.20])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 2.16, 95% CI [-24.13, 28.45], t(2068) = 0.16, p = 0.872; Std. beta = -2.81,
## 95% CI [-4.98, -0.64])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.96, 95% CI [-16.22, 20.13], t(2068) = 0.21, p = 0.833; Std. beta = 0.42,
## 95% CI [-0.90, 1.75])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.36, 95% CI [-29.49, 0.78], t(2068) = -1.86, p = 0.063; Std. beta = -0.58,
## 95% CI [-1.94, 0.78])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.96, 95% CI [-18.55, -1.37], t(2068) = -2.27, p = 0.023; Std. beta = -0.93,
## 95% CI [-2.02, 0.16])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 3.22, 95% CI [-0.56, 7.00], t(2068) =
## 1.67, p = 0.095; Std. beta = 0.10, 95% CI [-0.02, 0.21])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.15, 95% CI [-70.51, 2.21], t(2068) = -1.84, p = 0.066;
## Std. beta = -4.23, 95% CI [-8.73, 0.27])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.70, 95% CI [-12.36, 10.97], t(2068) = -0.12, p = 0.907;
## Std. beta = -0.09, 95% CI [-1.53, 1.36])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.12, 95% CI [-13.45, 11.20], t(2068) = -0.18, p = 0.858;
## Std. beta = -0.14, 95% CI [-1.67, 1.39])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.01, 95% CI [-17.84, 11.83], t(2068) = -0.40, p = 0.691;
## Std. beta = -0.37, 95% CI [-2.21, 1.47])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.90, 95% CI [-7.01, 12.80], t(2068) = 0.57, p = 0.566; Std.
## beta = 0.36, 95% CI [-0.87, 1.59])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.77, 95% CI [-4.79, 1.25], t(2068) = -1.15, p = 0.250; Std.
## beta = -0.22, 95% CI [-0.59, 0.15])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.51, 95% CI [-6.79, 9.81], t(2068) = 0.36, p = 0.722; Std.
## beta = 0.19, 95% CI [-0.84, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.14, 95% CI [-2.41, 2.69], t(2068) = 0.11, p = 0.914; Std.
## beta = 0.02, 95% CI [-0.30, 0.33])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-4.87, 4.33], t(2068) = -0.12, p = 0.908; Std.
## beta = -0.03, 95% CI [-0.60, 0.54])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 2.35, 95% CI [-2.92e-03, 4.71], t(2068) = 1.96, p = 0.050;
## Std. beta = 0.29, 95% CI [-3.63e-04, 0.58])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 3.48, 95% CI [-3.92, 10.89], t(2068) = 0.92, p = 0.356; Std.
## beta = 0.43, 95% CI [-0.49, 1.35])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-1.65, 3.57], t(2068) = 0.72, p = 0.470; Std.
## beta = 0.12, 95% CI [-0.20, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.21, 5.50], t(2068) = 1.25, p = 0.210; Std.
## beta = 0.27, 95% CI [-0.15, 0.68])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.17, 95% CI [-28.26, 3.92], t(2068) = -1.48, p = 0.138;
## Std. beta = -1.51, 95% CI [-3.50, 0.49])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.57, 95% CI [-1.46, 12.60], t(2068) = 1.55, p = 0.120; Std.
## beta = 0.69, 95% CI [-0.18, 1.56])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-0.30, 10.58], t(2068) = 1.85, p = 0.064; Std.
## beta = 0.64, 95% CI [-0.04, 1.31])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.59, 95% CI [-5.45, 10.64], t(2068) = 0.63, p = 0.527; Std.
## beta = 0.32, 95% CI [-0.68, 1.32])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-7.85, 7.70], t(2068) = -0.02, p = 0.985; Std.
## beta = -9.13e-03, 95% CI [-0.97, 0.95])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.29, 95% CI [-56.75, 36.17], t(2068) = -0.43, p = 0.664;
## Std. beta = -1.27, 95% CI [-7.03, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.64, 95% CI [-29.41, 26.12], t(2068) = -0.12, p = 0.908;
## Std. beta = -0.20, 95% CI [-3.64, 3.24])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.63, 95% CI [-5.85, 4.59], t(2068) = -0.24, p = 0.813; Std.
## beta = -0.08, 95% CI [-0.72, 0.57])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.14, 95% CI [-35.60, 15.33], t(2068) = -0.78, p = 0.435;
## Std. beta = -1.26, 95% CI [-4.41, 1.90])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-5.75, 13.55], t(2068) = 0.79, p = 0.428; Std.
## beta = 0.48, 95% CI [-0.71, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-4.96, 8.63], t(2068) = 0.53, p = 0.597; Std.
## beta = 0.23, 95% CI [-0.61, 1.07])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.31, 95% CI [-4.02, 14.65], t(2068) = 1.12, p = 0.264; Std.
## beta = 0.66, 95% CI [-0.50, 1.81])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.61, 10.42], t(2068) = 1.74, p = 0.081; Std.
## beta = 0.61, 95% CI [-0.08, 1.29])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-10.70, 10.55], t(2068) = -0.01, p = 0.989;
## Std. beta = -9.04e-03, 95% CI [-1.33, 1.31])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-7.47, 2.72], t(2068) = -0.91, p = 0.361; Std.
## beta = -0.29, 95% CI [-0.93, 0.34])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.18, 95% CI [-7.19, 4.82], t(2068) = -0.39, p = 0.699; Std.
## beta = -0.15, 95% CI [-0.89, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.32, 95% CI [-34.96, 16.31], t(2068) = -0.71, p = 0.476;
## Std. beta = -1.16, 95% CI [-4.33, 2.02])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.06, 95% CI [-12.12, 8.00], t(2068) = -0.40, p = 0.688; Std.
## beta = -0.26, 95% CI [-1.50, 0.99])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.88, 95% CI [-2.09, 5.84], t(2068) = 0.93, p = 0.353; Std.
## beta = 0.23, 95% CI [-0.26, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.37, 95% CI [-7.42, 6.69], t(2068) = -0.10, p = 0.919; Std.
## beta = -0.05, 95% CI [-0.92, 0.83])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-9.83, 5.22], t(2068) = -0.60, p = 0.548; Std.
## beta = -0.29, 95% CI [-1.22, 0.65])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.59, 95% CI [-3.20, 6.38], t(2068) = 0.65, p = 0.514; Std.
## beta = 0.20, 95% CI [-0.40, 0.79])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.81, 95% CI [0.58, 19.03], t(2068) = 2.08, p = 0.037; Std.
## beta = 1.21, 95% CI [0.07, 2.36])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.35, 95% CI [-0.47, 11.17], t(2068) = 1.80, p = 0.072; Std.
## beta = 0.66, 95% CI [-0.06, 1.38])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-6.95, 4.27], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.17, 95% CI [-0.86, 0.53])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.54, 95% CI [-5.34, 2.27], t(2068) = -0.79, p = 0.429; Std.
## beta = -0.19, 95% CI [-0.66, 0.28])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.77, 95% CI [-49.32, -8.22], t(2068) = -2.75, p = 0.006;
## Std. beta = -3.56, 95% CI [-6.11, -1.02])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.81, 95% CI [-6.35, 11.98], t(2068) = 0.60, p = 0.548; Std.
## beta = 0.35, 95% CI [-0.79, 1.48])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-9.17, 16.96], t(2068) = 0.58, p = 0.559; Std.
## beta = 0.48, 95% CI [-1.14, 2.10])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.46, 95% CI [-14.10, 9.18], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.30, 95% CI [-1.75, 1.14])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*BC_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14885
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1243 -0.4910 -0.0112 0.4507 7.0876
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 137.79 11.738
## time_firstPFT 11.06 3.325 -0.28
## Residual 41.83 6.468
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 43.93186 5.69229 7.718
## time_firstPFT -4.90400 2.65534 -1.847
## BC_5yrPreCensor -7.98584 3.88919 -2.053
## disadv -5.33336 2.32858 -2.290
## dich_RaceNon-White -2.61597 2.28641 -1.144
## sexF -2.34976 1.41512 -1.660
## age_dx 0.14731 0.07402 1.990
## smokeHxFormer -2.80534 1.40653 -1.995
## smokeHxAlways 8.33806 7.06167 1.181
## smokeHxUnknown -2.89481 3.17336 -0.912
## site02R -7.36325 13.47291 -0.547
## site03R 19.53579 9.89811 1.974
## site04R -6.57436 9.17868 -0.716
## site05R -14.56812 7.73508 -1.883
## site06R -7.56798 13.45876 -0.562
## site07R 1.25272 3.87904 0.323
## site09R -12.99028 9.39425 -1.383
## site101 17.21949 2.96707 5.804
## site102 4.33869 5.23313 0.829
## site103 -4.78246 2.76383 -1.730
## site104 -12.55779 5.57212 -2.254
## site105 -0.90777 2.96707 -0.306
## site106 -7.83269 3.58427 -2.185
## site107 4.74728 9.64655 0.492
## site108 -7.58567 8.17875 -0.927
## site10R -1.78905 13.52988 -0.132
## site11R -2.04767 5.69805 -0.359
## site12R -11.21898 9.41420 -1.192
## site13R -12.89962 7.28473 -1.771
## site14R -10.56385 14.96308 -0.706
## site15R -21.29112 13.52580 -1.574
## site16R -9.39786 5.94496 -1.581
## site17R 62.01242 13.61839 4.554
## site18R -5.06908 9.60852 -0.528
## site19R -10.97181 6.50202 -1.687
## site20R -5.66324 5.66205 -1.000
## site21R -12.30991 12.51693 -0.983
## site22R -15.17650 4.35257 -3.487
## site23R -27.57986 7.76650 -3.551
## site24R -1.22439 5.21165 -0.235
## site25R -10.84962 5.68413 -1.909
## site28R -16.14202 7.86552 -2.052
## site29R -5.52631 13.23540 -0.418
## site31R -2.34262 5.85147 -0.400
## site32R 2.19844 6.84346 0.321
## site33R -11.60058 6.68956 -1.734
## site34R -7.23110 5.11092 -1.415
## site35R -17.68116 7.98667 -2.214
## site36R 2.22874 5.92686 0.376
## site37R -0.87763 6.52634 -0.134
## site38R -2.62646 4.46529 -0.588
## site39R 10.15316 13.52070 0.751
## site40R 0.29939 9.18491 0.033
## site41R -15.29167 7.70345 -1.985
## site42R -11.76042 4.38844 -2.680
## time_firstPFT:BC_5yrPreCensor 2.77699 1.99073 1.395
## time_firstPFT:disadv 1.40605 1.10718 1.270
## time_firstPFT:dich_RaceNon-White -0.72408 1.11778 -0.648
## time_firstPFT:sexF 0.62169 0.66088 0.941
## time_firstPFT:age_dx -0.04262 0.03438 -1.240
## time_firstPFT:smokeHxFormer -0.63342 0.67144 -0.943
## time_firstPFT:smokeHxAlways -5.81250 6.05513 -0.960
## time_firstPFT:smokeHxUnknown 2.19496 1.66796 1.316
## time_firstPFT:site02R -32.49554 18.56093 -1.751
## time_firstPFT:site03R -0.25573 5.98735 -0.043
## time_firstPFT:site04R -1.88076 6.31238 -0.298
## time_firstPFT:site05R -2.83520 7.58600 -0.374
## time_firstPFT:site07R -1.26089 1.57289 -0.802
## time_firstPFT:site09R 2.53425 4.25096 0.596
## time_firstPFT:site101 0.20429 1.32605 0.154
## time_firstPFT:site102 0.21744 2.36022 0.092
## time_firstPFT:site103 2.59124 1.28137 2.022
## time_firstPFT:site104 2.99269 3.84964 0.777
## time_firstPFT:site105 0.94543 1.34571 0.703
## time_firstPFT:site106 2.66281 1.75925 1.514
## time_firstPFT:site107 -11.44325 8.21262 -1.393
## time_firstPFT:site108 6.20626 3.82209 1.624
## time_firstPFT:site11R 5.86897 2.82320 2.079
## time_firstPFT:site12R 2.95313 4.11712 0.717
## time_firstPFT:site13R -0.02037 3.98893 -0.005
## time_firstPFT:site14R -9.18227 23.71325 -0.387
## time_firstPFT:site15R -1.88884 14.17715 -0.133
## time_firstPFT:site16R -0.79899 2.70865 -0.295
## time_firstPFT:site18R -10.01046 13.00320 -0.770
## time_firstPFT:site19R 3.78547 4.99048 0.759
## time_firstPFT:site20R 1.60376 3.50663 0.457
## time_firstPFT:site21R 5.93258 4.75830 1.247
## time_firstPFT:site22R 6.13807 2.85790 2.148
## time_firstPFT:site23R 24.13028 26.75143 0.902
## time_firstPFT:site24R -2.14556 2.60208 -0.825
## time_firstPFT:site25R -0.23134 3.12626 -0.074
## time_firstPFT:site28R -8.35323 13.15526 -0.635
## time_firstPFT:site29R -0.51665 5.15675 -0.100
## time_firstPFT:site31R 2.62956 2.06972 1.270
## time_firstPFT:site32R 0.14595 3.63966 0.040
## time_firstPFT:site33R -2.84154 3.89423 -0.730
## time_firstPFT:site34R 1.70890 2.48654 0.687
## time_firstPFT:site35R 10.55826 4.75920 2.218
## time_firstPFT:site36R 5.42379 2.98361 1.818
## time_firstPFT:site37R -0.84233 2.96120 -0.284
## time_firstPFT:site38R -1.47182 1.95292 -0.754
## time_firstPFT:site39R -28.87773 10.57454 -2.731
## time_firstPFT:site40R 2.42129 4.73531 0.511
## time_firstPFT:site41R 4.84920 6.68730 0.725
## time_firstPFT:site42R -2.79700 5.95805 -0.469##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.800
## Unadjusted ICC: 0.524report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## BC_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.35. The model's intercept,
## corresponding to time_firstPFT = 0, is at 43.93 (95% CI [32.77, 55.10], t(2038)
## = 7.72, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## BC_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to
## BC_5yrPreCensor = 0, is at 43.93 (95% CI [32.77, 55.10], t(2038) = 7.72, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to disadv = 0, is at 43.93 (95% CI [32.77,
## 55.10], t(2038) = 7.72, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to dich_Race =
## White, is at 43.93 (95% CI [32.77, 55.10], t(2038) = 7.72, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to sex = M, is at 43.93 (95% CI [32.77,
## 55.10], t(2038) = 7.72, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to age_dx = 0, is at 43.93 (95% CI [32.77,
## 55.10], t(2038) = 7.72, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to smokeHx =
## Never, is at 43.93 (95% CI [32.77, 55.10], t(2038) = 7.72, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.35. The
## model's intercept, corresponding to site = Simmons, is at 43.93 (95% CI [32.77,
## 55.10], t(2038) = 7.72, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * BC_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.35. The model's intercept, corresponding to cohort =
## CARE-PF, is at 43.93 (95% CI [32.77, 55.10], t(2038) = 7.72, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.90, 95% CI [-10.11, 0.30], t(2038) = -1.85, p = 0.065; Std. beta =
## -0.61, 95% CI [-0.82, -0.41])
## - The effect of BC 5yrPreCensor is statistically significant and negative (beta
## = -7.99, 95% CI [-15.61, -0.36], t(2038) = -2.05, p = 0.040; Std. beta = -0.06,
## 95% CI [-0.20, 0.07])
## - The effect of disadv is statistically significant and negative (beta = -5.33,
## 95% CI [-9.90, -0.77], t(2038) = -2.29, p = 0.022; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.62, 95% CI [-7.10, 1.87], t(2038) = -1.14, p = 0.253; Std.
## beta = -0.25, 95% CI [-0.57, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.35, 95% CI [-5.12, 0.43], t(2038) = -1.66, p = 0.097; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [2.15e-03, 0.29], t(2038) = 1.99, p = 0.047; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.81, 95% CI [-5.56, -0.05], t(2038) = -1.99, p = 0.046; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.34, 95% CI [-5.51, 22.19], t(2038) = 1.18, p = 0.238; Std. beta =
## -0.03, 95% CI [-1.29, 1.22])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.12, 3.33], t(2038) = -0.91, p = 0.362; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -7.36, 95% CI [-33.79, 19.06], t(2038) = -0.55, p = 0.585; Std. beta = -3.85,
## 95% CI [-7.27, -0.44])
## - The effect of site [03R] is statistically significant and positive (beta =
## 19.54, 95% CI [0.12, 38.95], t(2038) = 1.97, p = 0.049; Std. beta = 1.30, 95%
## CI [0.02, 2.58])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-24.57, 11.43], t(2038) = -0.72, p = 0.474; Std. beta = -0.64,
## 95% CI [-2.09, 0.81])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -14.57, 95% CI [-29.74, 0.60], t(2038) = -1.88, p = 0.060; Std. beta = -1.28,
## 95% CI [-2.78, 0.22])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.57, 95% CI [-33.96, 18.83], t(2038) = -0.56, p = 0.574; Std. beta = -0.51,
## 95% CI [-2.31, 1.28])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 1.25, 95% CI [-6.35, 8.86], t(2038) = 0.32, p = 0.747; Std. beta = -0.04, 95%
## CI [-0.55, 0.46])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -12.99, 95% CI [-31.41, 5.43], t(2038) = -1.38, p = 0.167; Std. beta = -0.62,
## 95% CI [-1.90, 0.66])
## - The effect of site [101] is statistically significant and positive (beta =
## 17.22, 95% CI [11.40, 23.04], t(2038) = 5.80, p < .001; Std. beta = 1.19, 95%
## CI [0.79, 1.59])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 4.34, 95% CI [-5.92, 14.60], t(2038) = 0.83, p = 0.407; Std. beta = 0.32, 95%
## CI [-0.38, 1.01])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -4.78, 95% CI [-10.20, 0.64], t(2038) = -1.73, p = 0.084; Std. beta = -0.06,
## 95% CI [-0.44, 0.32])
## - The effect of site [104] is statistically significant and negative (beta =
## -12.56, 95% CI [-23.49, -1.63], t(2038) = -2.25, p = 0.024; Std. beta = -0.54,
## 95% CI [-1.45, 0.36])
## - The effect of site [105] is statistically non-significant and negative (beta
## = -0.91, 95% CI [-6.73, 4.91], t(2038) = -0.31, p = 0.760; Std. beta = 0.04,
## 95% CI [-0.36, 0.43])
## - The effect of site [106] is statistically significant and negative (beta =
## -7.83, 95% CI [-14.86, -0.80], t(2038) = -2.19, p = 0.029; Std. beta = -0.26,
## 95% CI [-0.73, 0.22])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 4.75, 95% CI [-14.17, 23.67], t(2038) = 0.49, p = 0.623; Std. beta = -0.86,
## 95% CI [-2.50, 0.79])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.59, 95% CI [-23.63, 8.45], t(2038) = -0.93, p = 0.354; Std. beta = 0.12,
## 95% CI [-0.95, 1.20])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -1.79, 95% CI [-28.32, 24.74], t(2038) = -0.13, p = 0.895; Std. beta = -0.12,
## 95% CI [-1.92, 1.68])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -2.05, 95% CI [-13.22, 9.13], t(2038) = -0.36, p = 0.719; Std. beta = 0.47,
## 95% CI [-0.33, 1.26])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-29.68, 7.24], t(2038) = -1.19, p = 0.234; Std. beta = -0.46,
## 95% CI [-1.75, 0.83])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -12.90, 95% CI [-27.19, 1.39], t(2038) = -1.77, p = 0.077; Std. beta = -0.88,
## 95% CI [-1.84, 0.09])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -10.56, 95% CI [-39.91, 18.78], t(2038) = -0.71, p = 0.480; Std. beta =
## -1.66, 95% CI [-5.10, 1.77])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -21.29, 95% CI [-47.82, 5.23], t(2038) = -1.57, p = 0.116; Std. beta = -1.64,
## 95% CI [-4.28, 0.99])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.40, 95% CI [-21.06, 2.26], t(2038) = -1.58, p = 0.114; Std. beta = -0.72,
## 95% CI [-1.54, 0.10])
## - The effect of site [17R] is statistically significant and positive (beta =
## 62.01, 95% CI [35.31, 88.72], t(2038) = 4.55, p < .001; Std. beta = 4.21, 95%
## CI [2.40, 6.03])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -5.07, 95% CI [-23.91, 13.77], t(2038) = -0.53, p = 0.598; Std. beta = -1.38,
## 95% CI [-3.91, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -10.97, 95% CI [-23.72, 1.78], t(2038) = -1.69, p = 0.092; Std. beta = -0.36,
## 95% CI [-1.45, 0.74])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -5.66, 95% CI [-16.77, 5.44], t(2038) = -1.00, p = 0.317; Std. beta = -0.22,
## 95% CI [-1.06, 0.62])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.31, 95% CI [-36.86, 12.24], t(2038) = -0.98, p = 0.325; Std. beta =
## -0.22, 95% CI [-1.80, 1.35])
## - The effect of site [22R] is statistically significant and negative (beta =
## -15.18, 95% CI [-23.71, -6.64], t(2038) = -3.49, p < .001; Std. beta = -0.40,
## 95% CI [-1.05, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -27.58, 95% CI [-42.81, -12.35], t(2038) = -3.55, p < .001; Std. beta = 0.61,
## 95% CI [-4.38, 5.61])
## - The effect of site [24R] is statistically non-significant and negative (beta
## = -1.22, 95% CI [-11.45, 9.00], t(2038) = -0.23, p = 0.814; Std. beta = -0.30,
## 95% CI [-1.01, 0.40])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -10.85, 95% CI [-22.00, 0.30], t(2038) = -1.91, p = 0.056; Std. beta = -0.76,
## 95% CI [-1.55, 0.02])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.14, 95% CI [-31.57, -0.72], t(2038) = -2.05, p = 0.040; Std. beta = -1.96,
## 95% CI [-4.55, 0.64])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -5.53, 95% CI [-31.48, 20.43], t(2038) = -0.42, p = 0.676; Std. beta = -0.43,
## 95% CI [-2.04, 1.19])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -2.34, 95% CI [-13.82, 9.13], t(2038) = -0.40, p = 0.689; Std. beta = 0.11,
## 95% CI [-0.63, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 2.20, 95% CI [-11.22, 15.62], t(2038) = 0.32, p = 0.748; Std. beta = 0.16,
## 95% CI [-0.79, 1.12])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -11.60, 95% CI [-24.72, 1.52], t(2038) = -1.73, p = 0.083; Std. beta = -1.08,
## 95% CI [-2.10, -0.07])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -7.23, 95% CI [-17.25, 2.79], t(2038) = -1.41, p = 0.157; Std. beta = -0.32,
## 95% CI [-1.01, 0.38])
## - The effect of site [35R] is statistically significant and negative (beta =
## -17.68, 95% CI [-33.34, -2.02], t(2038) = -2.21, p = 0.027; Std. beta = -0.11,
## 95% CI [-1.24, 1.02])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-9.39, 13.85], t(2038) = 0.38, p = 0.707; Std. beta = 0.71, 95%
## CI [-0.12, 1.55])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.88, 95% CI [-13.68, 11.92], t(2038) = -0.13, p = 0.893; Std. beta = -0.15,
## 95% CI [-1.01, 0.71])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -2.63, 95% CI [-11.38, 6.13], t(2038) = -0.59, p = 0.556; Std. beta = -0.33,
## 95% CI [-0.92, 0.26])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 10.15, 95% CI [-16.36, 36.67], t(2038) = 0.75, p = 0.453; Std. beta = -2.29,
## 95% CI [-4.50, -0.08])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.30, 95% CI [-17.71, 18.31], t(2038) = 0.03, p = 0.974; Std. beta = 0.27,
## 95% CI [-1.07, 1.61])
## - The effect of site [41R] is statistically significant and negative (beta =
## -15.29, 95% CI [-30.40, -0.18], t(2038) = -1.99, p = 0.047; Std. beta = -0.54,
## 95% CI [-1.91, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.76, 95% CI [-20.37, -3.15], t(2038) = -2.68, p = 0.007; Std. beta = -1.09,
## 95% CI [-2.19, 0.01])
## - The effect of time firstPFT × BC 5yrPreCensor is statistically
## non-significant and positive (beta = 2.78, 95% CI [-1.13, 6.68], t(2038) =
## 1.39, p = 0.163; Std. beta = 0.08, 95% CI [-0.03, 0.20])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.41, 95% CI [-0.77, 3.58], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.72, 95% CI [-2.92, 1.47], t(2038) =
## -0.65, p = 0.517; Std. beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.62, 95% CI [-0.67, 1.92], t(2038) = 0.94, p = 0.347; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.02], t(2038) = -1.24, p = 0.215; Std.
## beta = -0.05, 95% CI [-0.13, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-1.95, 0.68], t(2038) =
## -0.94, p = 0.346; Std. beta = -0.08, 95% CI [-0.24, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.81, 95% CI [-17.69, 6.06], t(2038) =
## -0.96, p = 0.337; Std. beta = -0.72, 95% CI [-2.19, 0.75])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.19, 95% CI [-1.08, 5.47], t(2038) =
## 1.32, p = 0.188; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -32.50, 95% CI [-68.90, 3.90], t(2038) = -1.75, p = 0.080;
## Std. beta = -4.03, 95% CI [-8.55, 0.48])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.26, 95% CI [-12.00, 11.49], t(2038) = -0.04, p = 0.966;
## Std. beta = -0.03, 95% CI [-1.49, 1.43])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.88, 95% CI [-14.26, 10.50], t(2038) = -0.30, p = 0.766;
## Std. beta = -0.23, 95% CI [-1.77, 1.30])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-17.71, 12.04], t(2038) = -0.37, p = 0.709;
## Std. beta = -0.35, 95% CI [-2.20, 1.49])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.26, 95% CI [-4.35, 1.82], t(2038) = -0.80, p = 0.423; Std.
## beta = -0.16, 95% CI [-0.54, 0.23])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.53, 95% CI [-5.80, 10.87], t(2038) = 0.60, p = 0.551; Std.
## beta = 0.31, 95% CI [-0.72, 1.35])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## positive (beta = 0.20, 95% CI [-2.40, 2.80], t(2038) = 0.15, p = 0.878; Std.
## beta = 0.03, 95% CI [-0.30, 0.35])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## positive (beta = 0.22, 95% CI [-4.41, 4.85], t(2038) = 0.09, p = 0.927; Std.
## beta = 0.03, 95% CI [-0.55, 0.60])
## - The effect of time firstPFT × site [103] is statistically significant and
## positive (beta = 2.59, 95% CI [0.08, 5.10], t(2038) = 2.02, p = 0.043; Std.
## beta = 0.32, 95% CI [9.72e-03, 0.63])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.99, 95% CI [-4.56, 10.54], t(2038) = 0.78, p = 0.437; Std.
## beta = 0.37, 95% CI [-0.57, 1.31])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.95, 95% CI [-1.69, 3.58], t(2038) = 0.70, p = 0.482; Std.
## beta = 0.12, 95% CI [-0.21, 0.44])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.66, 95% CI [-0.79, 6.11], t(2038) = 1.51, p = 0.130; Std.
## beta = 0.33, 95% CI [-0.10, 0.76])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -11.44, 95% CI [-27.55, 4.66], t(2038) = -1.39, p = 0.164;
## Std. beta = -1.42, 95% CI [-3.42, 0.58])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 6.21, 95% CI [-1.29, 13.70], t(2038) = 1.62, p = 0.105; Std.
## beta = 0.77, 95% CI [-0.16, 1.70])
## - The effect of time firstPFT × site [11R] is statistically significant and
## positive (beta = 5.87, 95% CI [0.33, 11.41], t(2038) = 2.08, p = 0.038; Std.
## beta = 0.73, 95% CI [0.04, 1.42])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.95, 95% CI [-5.12, 11.03], t(2038) = 0.72, p = 0.473; Std.
## beta = 0.37, 95% CI [-0.64, 1.37])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.02, 95% CI [-7.84, 7.80], t(2038) = -5.11e-03, p = 0.996;
## Std. beta = -2.53e-03, 95% CI [-0.97, 0.97])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.18, 95% CI [-55.69, 37.32], t(2038) = -0.39, p = 0.699;
## Std. beta = -1.14, 95% CI [-6.91, 4.63])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -1.89, 95% CI [-29.69, 25.91], t(2038) = -0.13, p = 0.894;
## Std. beta = -0.23, 95% CI [-3.68, 3.22])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-6.11, 4.51], t(2038) = -0.29, p = 0.768; Std.
## beta = -0.10, 95% CI [-0.76, 0.56])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.01, 95% CI [-35.51, 15.49], t(2038) = -0.77, p = 0.441;
## Std. beta = -1.24, 95% CI [-4.41, 1.92])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.79, 95% CI [-6.00, 13.57], t(2038) = 0.76, p = 0.448; Std.
## beta = 0.47, 95% CI [-0.74, 1.68])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.60, 95% CI [-5.27, 8.48], t(2038) = 0.46, p = 0.647; Std.
## beta = 0.20, 95% CI [-0.65, 1.05])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.93, 95% CI [-3.40, 15.26], t(2038) = 1.25, p = 0.213; Std.
## beta = 0.74, 95% CI [-0.42, 1.89])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 6.14, 95% CI [0.53, 11.74], t(2038) = 2.15, p = 0.032; Std.
## beta = 0.76, 95% CI [0.07, 1.46])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 24.13, 95% CI [-28.33, 76.59], t(2038) = 0.90, p = 0.367; Std.
## beta = 2.99, 95% CI [-3.52, 9.50])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.25, 2.96], t(2038) = -0.82, p = 0.410; Std.
## beta = -0.27, 95% CI [-0.90, 0.37])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -0.23, 95% CI [-6.36, 5.90], t(2038) = -0.07, p = 0.941; Std.
## beta = -0.03, 95% CI [-0.79, 0.73])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.35, 95% CI [-34.15, 17.45], t(2038) = -0.63, p = 0.526;
## Std. beta = -1.04, 95% CI [-4.24, 2.16])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.52, 95% CI [-10.63, 9.60], t(2038) = -0.10, p = 0.920; Std.
## beta = -0.06, 95% CI [-1.32, 1.19])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.63, 95% CI [-1.43, 6.69], t(2038) = 1.27, p = 0.204; Std.
## beta = 0.33, 95% CI [-0.18, 0.83])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## positive (beta = 0.15, 95% CI [-6.99, 7.28], t(2038) = 0.04, p = 0.968; Std.
## beta = 0.02, 95% CI [-0.87, 0.90])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.84, 95% CI [-10.48, 4.80], t(2038) = -0.73, p = 0.466; Std.
## beta = -0.35, 95% CI [-1.30, 0.59])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.71, 95% CI [-3.17, 6.59], t(2038) = 0.69, p = 0.492; Std.
## beta = 0.21, 95% CI [-0.39, 0.82])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 10.56, 95% CI [1.22, 19.89], t(2038) = 2.22, p = 0.027; Std.
## beta = 1.31, 95% CI [0.15, 2.47])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.42, 95% CI [-0.43, 11.28], t(2038) = 1.82, p = 0.069; Std.
## beta = 0.67, 95% CI [-0.05, 1.40])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -0.84, 95% CI [-6.65, 4.96], t(2038) = -0.28, p = 0.776; Std.
## beta = -0.10, 95% CI [-0.83, 0.62])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.30, 2.36], t(2038) = -0.75, p = 0.451; Std.
## beta = -0.18, 95% CI [-0.66, 0.29])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -28.88, 95% CI [-49.62, -8.14], t(2038) = -2.73, p = 0.006;
## Std. beta = -3.58, 95% CI [-6.16, -1.01])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.42, 95% CI [-6.87, 11.71], t(2038) = 0.51, p = 0.609; Std.
## beta = 0.30, 95% CI [-0.85, 1.45])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.85, 95% CI [-8.27, 17.96], t(2038) = 0.73, p = 0.468; Std.
## beta = 0.60, 95% CI [-1.03, 2.23])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.80, 95% CI [-14.48, 8.89], t(2038) = -0.47, p = 0.639; Std.
## beta = -0.35, 95% CI [-1.80, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*OM_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15062
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1455 -0.4978 -0.0109 0.4434 7.1034
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 142.12 11.922
## time_firstPFT 11.06 3.325 -0.30
## Residual 41.78 6.464
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 46.4566 2.6278 17.679
## time_firstPFT -6.6662 1.2372 -5.388
## OM_5yrPreCensor -1.8495 0.7269 -2.544
## site02R -1.5570 13.5402 -0.115
## site03R 25.0213 9.8602 2.538
## site04R -6.3693 9.2477 -0.689
## site05R -13.2744 7.7421 -1.715
## site06R 7.9278 9.7090 0.817
## site07R 4.5225 3.7039 1.221
## site09R -9.6051 9.3999 -1.022
## site101 18.7735 2.5879 7.254
## site102 8.0270 4.9351 1.627
## site103 -2.0628 2.1534 -0.958
## site104 -10.8065 5.1932 -2.081
## site105 1.4683 2.4791 0.592
## site106 -4.0827 3.3624 -1.214
## site107 9.2742 9.5827 0.968
## site108 -9.8323 7.5250 -1.307
## site10R -2.0217 13.3629 -0.151
## site11R 1.3828 5.7470 0.241
## site12R -11.1237 9.3618 -1.188
## site13R -10.4468 7.2840 -1.434
## site14R -8.0467 14.9765 -0.537
## site15R -22.6517 13.5968 -1.666
## site16R -9.0727 5.8745 -1.544
## site17R 59.2116 13.6008 4.354
## site18R -4.6668 9.6168 -0.485
## site19R -8.5206 6.2563 -1.362
## site20R -3.8299 5.5630 -0.688
## site21R -10.7483 12.6865 -0.847
## site22R -12.2298 4.2761 -2.860
## site23R -19.3842 6.1143 -3.170
## site24R 0.6928 5.0665 0.137
## site25R -5.9863 5.5309 -1.082
## site28R -16.6948 7.8846 -2.117
## site29R -1.3080 13.2927 -0.098
## site31R -0.3193 5.7647 -0.055
## site32R 3.6432 6.6859 0.545
## site33R -9.6398 6.6055 -1.459
## site34R -5.9995 5.0142 -1.196
## site35R -15.2948 7.8500 -1.948
## site36R 3.7454 5.9291 0.632
## site37R 1.7724 6.4705 0.274
## site38R -1.4002 4.4047 -0.318
## site39R 4.4326 13.2671 0.334
## site40R 2.4698 9.2576 0.267
## site41R -13.8143 7.6919 -1.796
## site42R -9.2572 4.3342 -2.136
## time_firstPFT:OM_5yrPreCensor 0.7233 0.3495 2.070
## time_firstPFT:site02R -34.9461 18.5338 -1.886
## time_firstPFT:site03R -1.1434 5.9336 -0.193
## time_firstPFT:site04R -1.4500 6.2578 -0.232
## time_firstPFT:site05R -3.3694 7.5517 -0.446
## time_firstPFT:site06R 1.8158 5.0750 0.358
## time_firstPFT:site07R -2.3791 1.4132 -1.684
## time_firstPFT:site09R 0.9717 4.2035 0.231
## time_firstPFT:site101 -0.5492 1.0878 -0.505
## time_firstPFT:site102 -1.3343 2.1734 -0.614
## time_firstPFT:site103 1.1767 0.9451 1.245
## time_firstPFT:site104 2.2259 3.7204 0.598
## time_firstPFT:site105 -0.1941 1.0628 -0.183
## time_firstPFT:site106 1.4570 1.6048 0.908
## time_firstPFT:site107 -13.0314 8.1580 -1.597
## time_firstPFT:site108 4.5560 3.4002 1.340
## time_firstPFT:site11R 4.1067 2.7798 1.477
## time_firstPFT:site12R 1.8499 4.0062 0.462
## time_firstPFT:site13R -0.4110 3.9318 -0.105
## time_firstPFT:site14R -10.5141 23.6890 -0.444
## time_firstPFT:site15R -2.4205 14.1512 -0.171
## time_firstPFT:site16R -0.9021 2.6213 -0.344
## time_firstPFT:site18R -10.8741 12.9779 -0.838
## time_firstPFT:site19R 3.3592 4.8495 0.693
## time_firstPFT:site20R 1.2129 3.3963 0.357
## time_firstPFT:site21R 4.5913 4.7547 0.966
## time_firstPFT:site22R 4.7391 2.7799 1.705
## time_firstPFT:site23R -0.8527 5.3698 -0.159
## time_firstPFT:site24R -2.9740 2.4904 -1.194
## time_firstPFT:site25R -2.0666 2.9619 -0.698
## time_firstPFT:site28R -9.6220 13.0702 -0.736
## time_firstPFT:site29R -2.3058 5.0856 -0.453
## time_firstPFT:site31R 1.3683 1.9546 0.700
## time_firstPFT:site32R -1.0039 3.5455 -0.283
## time_firstPFT:site33R -2.8493 3.7614 -0.758
## time_firstPFT:site34R 1.1061 2.3695 0.467
## time_firstPFT:site35R 9.1761 4.6186 1.987
## time_firstPFT:site36R 4.9480 2.9452 1.680
## time_firstPFT:site37R -1.6185 2.8435 -0.569
## time_firstPFT:site38R -2.2578 1.8851 -1.198
## time_firstPFT:site39R -29.4749 10.4333 -2.825
## time_firstPFT:site40R 2.4715 4.5892 0.539
## time_firstPFT:site41R 3.7288 6.6539 0.560
## time_firstPFT:site42R -2.7087 5.9242 -0.457##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.801
## Unadjusted ICC: 0.531report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## OM_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.34. The model's
## intercept, corresponding to time_firstPFT = 0, is at 46.46 (95% CI [41.30,
## 51.61], t(2068) = 17.68, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-9.09, -4.24], t(2068) = -5.39, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.44])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.85, 95% CI [-3.28, -0.42], t(2068) = -2.54, p = 0.011; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-28.11, 25.00], t(2068) = -0.11, p = 0.908; Std. beta = -3.70,
## 95% CI [-7.10, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.02, 95% CI [5.68, 44.36], t(2068) = 2.54, p = 0.011; Std. beta = 1.58, 95%
## CI [0.32, 2.85])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-24.51, 11.77], t(2068) = -0.69, p = 0.491; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-28.46, 1.91], t(2068) = -1.71, p = 0.087; Std. beta = -1.25,
## 95% CI [-2.74, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.93, 95% CI [-11.11, 26.97], t(2068) = 0.82, p = 0.414; Std. beta = 0.73,
## 95% CI [-0.65, 2.10])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.52, 95% CI [-2.74, 11.79], t(2068) = 1.22, p = 0.222; Std. beta = 0.06, 95%
## CI [-0.41, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.61, 95% CI [-28.04, 8.83], t(2068) = -1.02, p = 0.307; Std. beta = -0.55,
## 95% CI [-1.82, 0.71])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.77, 95% CI [13.70, 23.85], t(2068) = 7.25, p < .001; Std. beta = 1.22, 95%
## CI [0.88, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.03, 95% CI [-1.65, 17.71], t(2068) = 1.63, p = 0.104; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-6.29, 2.16], t(2068) = -0.96, p = 0.338; Std. beta = -0.02,
## 95% CI [-0.30, 0.27])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.81, 95% CI [-20.99, -0.62], t(2068) = -2.08, p = 0.038; Std. beta = -0.51,
## 95% CI [-1.37, 0.35])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-3.39, 6.33], t(2068) = 0.59, p = 0.554; Std. beta = 0.08, 95%
## CI [-0.24, 0.40])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-10.68, 2.51], t(2068) = -1.21, p = 0.225; Std. beta = -0.13,
## 95% CI [-0.56, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-9.52, 28.07], t(2068) = 0.97, p = 0.333; Std. beta = -0.71,
## 95% CI [-2.33, 0.92])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-24.59, 4.93], t(2068) = -1.31, p = 0.191; Std. beta = -0.20,
## 95% CI [-1.16, 0.76])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-28.23, 24.18], t(2068) = -0.15, p = 0.880; Std. beta = -0.14,
## 95% CI [-1.92, 1.64])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.38, 95% CI [-9.89, 12.65], t(2068) = 0.24, p = 0.810; Std. beta = 0.52, 95%
## CI [-0.28, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.12, 95% CI [-29.48, 7.24], t(2068) = -1.19, p = 0.235; Std. beta = -0.57,
## 95% CI [-1.84, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-24.73, 3.84], t(2068) = -1.43, p = 0.152; Std. beta = -0.75,
## 95% CI [-1.70, 0.20])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.05, 95% CI [-37.42, 21.32], t(2068) = -0.54, p = 0.591; Std. beta = -1.63,
## 95% CI [-5.04, 1.79])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.65, 95% CI [-49.32, 4.01], t(2068) = -1.67, p = 0.096; Std. beta = -1.79,
## 95% CI [-4.41, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-20.59, 2.45], t(2068) = -1.54, p = 0.123; Std. beta = -0.71,
## 95% CI [-1.51, 0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.21, 95% CI [32.54, 85.88], t(2068) = 4.35, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.84])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-23.53, 14.19], t(2068) = -0.49, p = 0.628; Std. beta = -1.44,
## 95% CI [-3.95, 1.08])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-20.79, 3.75], t(2068) = -1.36, p = 0.173; Std. beta = -0.23,
## 95% CI [-1.28, 0.82])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.83, 95% CI [-14.74, 7.08], t(2068) = -0.69, p = 0.491; Std. beta = -0.14,
## 95% CI [-0.94, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-35.63, 14.13], t(2068) = -0.85, p = 0.397; Std. beta =
## -0.26, 95% CI [-1.84, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.23, 95% CI [-20.62, -3.84], t(2068) = -2.86, p = 0.004; Std. beta = -0.34,
## 95% CI [-0.98, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.38, 95% CI [-31.37, -7.39], t(2068) = -3.17, p = 0.002; Std. beta = -1.41,
## 95% CI [-2.56, -0.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.69, 95% CI [-9.24, 10.63], t(2068) = 0.14, p = 0.891; Std. beta = -0.26,
## 95% CI [-0.94, 0.42])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.83, 4.86], t(2068) = -1.08, p = 0.279; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.69, 95% CI [-32.16, -1.23], t(2068) = -2.12, p = 0.034; Std. beta = -2.12,
## 95% CI [-4.69, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-27.38, 24.76], t(2068) = -0.10, p = 0.922; Std. beta = -0.33,
## 95% CI [-1.93, 1.28])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.32, 95% CI [-11.62, 10.99], t(2068) = -0.06, p = 0.956; Std. beta = 0.12,
## 95% CI [-0.60, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-9.47, 16.76], t(2068) = 0.54, p = 0.586; Std. beta = 0.14, 95%
## CI [-0.78, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.64, 95% CI [-22.59, 3.31], t(2068) = -1.46, p = 0.145; Std. beta = -0.95,
## 95% CI [-1.94, 0.04])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-15.83, 3.83], t(2068) = -1.20, p = 0.232; Std. beta = -0.29,
## 95% CI [-0.97, 0.38])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.29, 95% CI [-30.69, 0.10], t(2068) = -1.95, p = 0.052; Std. beta = -0.10,
## 95% CI [-1.19, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-7.88, 15.37], t(2068) = 0.63, p = 0.528; Std. beta = 0.76, 95%
## CI [-0.06, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.77, 95% CI [-10.92, 14.46], t(2068) = 0.27, p = 0.784; Std. beta = -0.05,
## 95% CI [-0.89, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-10.04, 7.24], t(2068) = -0.32, p = 0.751; Std. beta = -0.33,
## 95% CI [-0.90, 0.24])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-21.59, 30.45], t(2068) = 0.33, p = 0.738; Std. beta = -2.73,
## 95% CI [-4.89, -0.57])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-15.69, 20.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.42,
## 95% CI [-0.89, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.81, 95% CI [-28.90, 1.27], t(2068) = -1.80, p = 0.073; Std. beta = -0.56,
## 95% CI [-1.92, 0.80])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.26, 95% CI [-17.76, -0.76], t(2068) = -2.14, p = 0.033; Std. beta = -0.91,
## 95% CI [-1.99, 0.18])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically significant
## and positive (beta = 0.72, 95% CI [0.04, 1.41], t(2068) = 2.07, p = 0.039; Std.
## beta = 0.08, 95% CI [4.29e-03, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.95, 95% CI [-71.29, 1.40], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.33, 95% CI [-8.83, 0.17])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-12.78, 10.49], t(2068) = -0.19, p = 0.847;
## Std. beta = -0.14, 95% CI [-1.58, 1.30])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.72, 10.82], t(2068) = -0.23, p = 0.817;
## Std. beta = -0.18, 95% CI [-1.70, 1.34])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.37, 95% CI [-18.18, 11.44], t(2068) = -0.45, p = 0.656;
## Std. beta = -0.42, 95% CI [-2.25, 1.42])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.14, 11.77], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.22, 95% CI [-1.01, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-5.15, 0.39], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.29, 95% CI [-0.64, 0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-7.27, 9.22], t(2068) = 0.23, p = 0.817; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-2.68, 1.58], t(2068) = -0.50, p = 0.614; Std.
## beta = -0.07, 95% CI [-0.33, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-5.60, 2.93], t(2068) = -0.61, p = 0.539; Std.
## beta = -0.17, 95% CI [-0.69, 0.36])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-0.68, 3.03], t(2068) = 1.25, p = 0.213; Std.
## beta = 0.15, 95% CI [-0.08, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.23, 95% CI [-5.07, 9.52], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.28, 95% CI [-0.63, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.19, 95% CI [-2.28, 1.89], t(2068) = -0.18, p = 0.855; Std.
## beta = -0.02, 95% CI [-0.28, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.69, 4.60], t(2068) = 0.91, p = 0.364; Std.
## beta = 0.18, 95% CI [-0.21, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.03, 95% CI [-29.03, 2.97], t(2068) = -1.60, p = 0.110;
## Std. beta = -1.61, 95% CI [-3.60, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-2.11, 11.22], t(2068) = 1.34, p = 0.180; Std.
## beta = 0.56, 95% CI [-0.26, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.11, 95% CI [-1.34, 9.56], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.51, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-6.01, 9.71], t(2068) = 0.46, p = 0.644; Std.
## beta = 0.23, 95% CI [-0.74, 1.20])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-8.12, 7.30], t(2068) = -0.10, p = 0.917; Std.
## beta = -0.05, 95% CI [-1.01, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.51, 95% CI [-56.97, 35.94], t(2068) = -0.44, p = 0.657;
## Std. beta = -1.30, 95% CI [-7.06, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-30.17, 25.33], t(2068) = -0.17, p = 0.864;
## Std. beta = -0.30, 95% CI [-3.74, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-6.04, 4.24], t(2068) = -0.34, p = 0.731; Std.
## beta = -0.11, 95% CI [-0.75, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.87, 95% CI [-36.33, 14.58], t(2068) = -0.84, p = 0.402;
## Std. beta = -1.35, 95% CI [-4.50, 1.81])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-6.15, 12.87], t(2068) = 0.69, p = 0.489; Std.
## beta = 0.42, 95% CI [-0.76, 1.59])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-5.45, 7.87], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.15, 95% CI [-0.67, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.59, 95% CI [-4.73, 13.92], t(2068) = 0.97, p = 0.334; Std.
## beta = 0.57, 95% CI [-0.59, 1.72])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.74, 95% CI [-0.71, 10.19], t(2068) = 1.70, p = 0.088; Std.
## beta = 0.59, 95% CI [-0.09, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-11.38, 9.68], t(2068) = -0.16, p = 0.874; Std.
## beta = -0.11, 95% CI [-1.41, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.86, 1.91], t(2068) = -1.19, p = 0.233; Std.
## beta = -0.37, 95% CI [-0.97, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.88, 3.74], t(2068) = -0.70, p = 0.485; Std.
## beta = -0.26, 95% CI [-0.98, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.25, 16.01], t(2068) = -0.74, p = 0.462;
## Std. beta = -1.19, 95% CI [-4.37, 1.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-12.28, 7.67], t(2068) = -0.45, p = 0.650; Std.
## beta = -0.29, 95% CI [-1.52, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.37, 95% CI [-2.46, 5.20], t(2068) = 0.70, p = 0.484; Std.
## beta = 0.17, 95% CI [-0.31, 0.64])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-7.96, 5.95], t(2068) = -0.28, p = 0.777; Std.
## beta = -0.12, 95% CI [-0.99, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-10.23, 4.53], t(2068) = -0.76, p = 0.449; Std.
## beta = -0.35, 95% CI [-1.27, 0.56])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-3.54, 5.75], t(2068) = 0.47, p = 0.641; Std.
## beta = 0.14, 95% CI [-0.44, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.18, 95% CI [0.12, 18.23], t(2068) = 1.99, p = 0.047; Std.
## beta = 1.14, 95% CI [0.01, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.95, 95% CI [-0.83, 10.72], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.61, 95% CI [-0.10, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-7.19, 3.96], t(2068) = -0.57, p = 0.569; Std.
## beta = -0.20, 95% CI [-0.89, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-5.95, 1.44], t(2068) = -1.20, p = 0.231; Std.
## beta = -0.28, 95% CI [-0.74, 0.18])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.47, 95% CI [-49.94, -9.01], t(2068) = -2.83, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-6.53, 11.47], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.31, 95% CI [-0.81, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-9.32, 16.78], t(2068) = 0.56, p = 0.575; Std.
## beta = 0.46, 95% CI [-1.15, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-14.33, 8.91], t(2068) = -0.46, p = 0.648; Std.
## beta = -0.34, 95% CI [-1.77, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## OM_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to OM_5yrPreCensor = 0, is at 46.46 (95% CI [41.30, 51.61],
## t(2068) = 17.68, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-9.09, -4.24], t(2068) = -5.39, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.44])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.85, 95% CI [-3.28, -0.42], t(2068) = -2.54, p = 0.011; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-28.11, 25.00], t(2068) = -0.11, p = 0.908; Std. beta = -3.70,
## 95% CI [-7.10, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.02, 95% CI [5.68, 44.36], t(2068) = 2.54, p = 0.011; Std. beta = 1.58, 95%
## CI [0.32, 2.85])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-24.51, 11.77], t(2068) = -0.69, p = 0.491; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-28.46, 1.91], t(2068) = -1.71, p = 0.087; Std. beta = -1.25,
## 95% CI [-2.74, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.93, 95% CI [-11.11, 26.97], t(2068) = 0.82, p = 0.414; Std. beta = 0.73,
## 95% CI [-0.65, 2.10])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.52, 95% CI [-2.74, 11.79], t(2068) = 1.22, p = 0.222; Std. beta = 0.06, 95%
## CI [-0.41, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.61, 95% CI [-28.04, 8.83], t(2068) = -1.02, p = 0.307; Std. beta = -0.55,
## 95% CI [-1.82, 0.71])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.77, 95% CI [13.70, 23.85], t(2068) = 7.25, p < .001; Std. beta = 1.22, 95%
## CI [0.88, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.03, 95% CI [-1.65, 17.71], t(2068) = 1.63, p = 0.104; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-6.29, 2.16], t(2068) = -0.96, p = 0.338; Std. beta = -0.02,
## 95% CI [-0.30, 0.27])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.81, 95% CI [-20.99, -0.62], t(2068) = -2.08, p = 0.038; Std. beta = -0.51,
## 95% CI [-1.37, 0.35])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-3.39, 6.33], t(2068) = 0.59, p = 0.554; Std. beta = 0.08, 95%
## CI [-0.24, 0.40])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-10.68, 2.51], t(2068) = -1.21, p = 0.225; Std. beta = -0.13,
## 95% CI [-0.56, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-9.52, 28.07], t(2068) = 0.97, p = 0.333; Std. beta = -0.71,
## 95% CI [-2.33, 0.92])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-24.59, 4.93], t(2068) = -1.31, p = 0.191; Std. beta = -0.20,
## 95% CI [-1.16, 0.76])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-28.23, 24.18], t(2068) = -0.15, p = 0.880; Std. beta = -0.14,
## 95% CI [-1.92, 1.64])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.38, 95% CI [-9.89, 12.65], t(2068) = 0.24, p = 0.810; Std. beta = 0.52, 95%
## CI [-0.28, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.12, 95% CI [-29.48, 7.24], t(2068) = -1.19, p = 0.235; Std. beta = -0.57,
## 95% CI [-1.84, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-24.73, 3.84], t(2068) = -1.43, p = 0.152; Std. beta = -0.75,
## 95% CI [-1.70, 0.20])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.05, 95% CI [-37.42, 21.32], t(2068) = -0.54, p = 0.591; Std. beta = -1.63,
## 95% CI [-5.04, 1.79])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.65, 95% CI [-49.32, 4.01], t(2068) = -1.67, p = 0.096; Std. beta = -1.79,
## 95% CI [-4.41, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-20.59, 2.45], t(2068) = -1.54, p = 0.123; Std. beta = -0.71,
## 95% CI [-1.51, 0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.21, 95% CI [32.54, 85.88], t(2068) = 4.35, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.84])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-23.53, 14.19], t(2068) = -0.49, p = 0.628; Std. beta = -1.44,
## 95% CI [-3.95, 1.08])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-20.79, 3.75], t(2068) = -1.36, p = 0.173; Std. beta = -0.23,
## 95% CI [-1.28, 0.82])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.83, 95% CI [-14.74, 7.08], t(2068) = -0.69, p = 0.491; Std. beta = -0.14,
## 95% CI [-0.94, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-35.63, 14.13], t(2068) = -0.85, p = 0.397; Std. beta =
## -0.26, 95% CI [-1.84, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.23, 95% CI [-20.62, -3.84], t(2068) = -2.86, p = 0.004; Std. beta = -0.34,
## 95% CI [-0.98, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.38, 95% CI [-31.37, -7.39], t(2068) = -3.17, p = 0.002; Std. beta = -1.41,
## 95% CI [-2.56, -0.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.69, 95% CI [-9.24, 10.63], t(2068) = 0.14, p = 0.891; Std. beta = -0.26,
## 95% CI [-0.94, 0.42])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.83, 4.86], t(2068) = -1.08, p = 0.279; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.69, 95% CI [-32.16, -1.23], t(2068) = -2.12, p = 0.034; Std. beta = -2.12,
## 95% CI [-4.69, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-27.38, 24.76], t(2068) = -0.10, p = 0.922; Std. beta = -0.33,
## 95% CI [-1.93, 1.28])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.32, 95% CI [-11.62, 10.99], t(2068) = -0.06, p = 0.956; Std. beta = 0.12,
## 95% CI [-0.60, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-9.47, 16.76], t(2068) = 0.54, p = 0.586; Std. beta = 0.14, 95%
## CI [-0.78, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.64, 95% CI [-22.59, 3.31], t(2068) = -1.46, p = 0.145; Std. beta = -0.95,
## 95% CI [-1.94, 0.04])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-15.83, 3.83], t(2068) = -1.20, p = 0.232; Std. beta = -0.29,
## 95% CI [-0.97, 0.38])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.29, 95% CI [-30.69, 0.10], t(2068) = -1.95, p = 0.052; Std. beta = -0.10,
## 95% CI [-1.19, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-7.88, 15.37], t(2068) = 0.63, p = 0.528; Std. beta = 0.76, 95%
## CI [-0.06, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.77, 95% CI [-10.92, 14.46], t(2068) = 0.27, p = 0.784; Std. beta = -0.05,
## 95% CI [-0.89, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-10.04, 7.24], t(2068) = -0.32, p = 0.751; Std. beta = -0.33,
## 95% CI [-0.90, 0.24])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-21.59, 30.45], t(2068) = 0.33, p = 0.738; Std. beta = -2.73,
## 95% CI [-4.89, -0.57])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-15.69, 20.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.42,
## 95% CI [-0.89, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.81, 95% CI [-28.90, 1.27], t(2068) = -1.80, p = 0.073; Std. beta = -0.56,
## 95% CI [-1.92, 0.80])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.26, 95% CI [-17.76, -0.76], t(2068) = -2.14, p = 0.033; Std. beta = -0.91,
## 95% CI [-1.99, 0.18])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically significant
## and positive (beta = 0.72, 95% CI [0.04, 1.41], t(2068) = 2.07, p = 0.039; Std.
## beta = 0.08, 95% CI [4.29e-03, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.95, 95% CI [-71.29, 1.40], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.33, 95% CI [-8.83, 0.17])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-12.78, 10.49], t(2068) = -0.19, p = 0.847;
## Std. beta = -0.14, 95% CI [-1.58, 1.30])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.72, 10.82], t(2068) = -0.23, p = 0.817;
## Std. beta = -0.18, 95% CI [-1.70, 1.34])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.37, 95% CI [-18.18, 11.44], t(2068) = -0.45, p = 0.656;
## Std. beta = -0.42, 95% CI [-2.25, 1.42])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.14, 11.77], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.22, 95% CI [-1.01, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-5.15, 0.39], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.29, 95% CI [-0.64, 0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-7.27, 9.22], t(2068) = 0.23, p = 0.817; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-2.68, 1.58], t(2068) = -0.50, p = 0.614; Std.
## beta = -0.07, 95% CI [-0.33, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-5.60, 2.93], t(2068) = -0.61, p = 0.539; Std.
## beta = -0.17, 95% CI [-0.69, 0.36])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-0.68, 3.03], t(2068) = 1.25, p = 0.213; Std.
## beta = 0.15, 95% CI [-0.08, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.23, 95% CI [-5.07, 9.52], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.28, 95% CI [-0.63, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.19, 95% CI [-2.28, 1.89], t(2068) = -0.18, p = 0.855; Std.
## beta = -0.02, 95% CI [-0.28, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.69, 4.60], t(2068) = 0.91, p = 0.364; Std.
## beta = 0.18, 95% CI [-0.21, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.03, 95% CI [-29.03, 2.97], t(2068) = -1.60, p = 0.110;
## Std. beta = -1.61, 95% CI [-3.60, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-2.11, 11.22], t(2068) = 1.34, p = 0.180; Std.
## beta = 0.56, 95% CI [-0.26, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.11, 95% CI [-1.34, 9.56], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.51, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-6.01, 9.71], t(2068) = 0.46, p = 0.644; Std.
## beta = 0.23, 95% CI [-0.74, 1.20])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-8.12, 7.30], t(2068) = -0.10, p = 0.917; Std.
## beta = -0.05, 95% CI [-1.01, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.51, 95% CI [-56.97, 35.94], t(2068) = -0.44, p = 0.657;
## Std. beta = -1.30, 95% CI [-7.06, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-30.17, 25.33], t(2068) = -0.17, p = 0.864;
## Std. beta = -0.30, 95% CI [-3.74, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-6.04, 4.24], t(2068) = -0.34, p = 0.731; Std.
## beta = -0.11, 95% CI [-0.75, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.87, 95% CI [-36.33, 14.58], t(2068) = -0.84, p = 0.402;
## Std. beta = -1.35, 95% CI [-4.50, 1.81])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-6.15, 12.87], t(2068) = 0.69, p = 0.489; Std.
## beta = 0.42, 95% CI [-0.76, 1.59])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-5.45, 7.87], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.15, 95% CI [-0.67, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.59, 95% CI [-4.73, 13.92], t(2068) = 0.97, p = 0.334; Std.
## beta = 0.57, 95% CI [-0.59, 1.72])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.74, 95% CI [-0.71, 10.19], t(2068) = 1.70, p = 0.088; Std.
## beta = 0.59, 95% CI [-0.09, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-11.38, 9.68], t(2068) = -0.16, p = 0.874; Std.
## beta = -0.11, 95% CI [-1.41, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.86, 1.91], t(2068) = -1.19, p = 0.233; Std.
## beta = -0.37, 95% CI [-0.97, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.88, 3.74], t(2068) = -0.70, p = 0.485; Std.
## beta = -0.26, 95% CI [-0.98, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.25, 16.01], t(2068) = -0.74, p = 0.462;
## Std. beta = -1.19, 95% CI [-4.37, 1.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-12.28, 7.67], t(2068) = -0.45, p = 0.650; Std.
## beta = -0.29, 95% CI [-1.52, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.37, 95% CI [-2.46, 5.20], t(2068) = 0.70, p = 0.484; Std.
## beta = 0.17, 95% CI [-0.31, 0.64])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-7.96, 5.95], t(2068) = -0.28, p = 0.777; Std.
## beta = -0.12, 95% CI [-0.99, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-10.23, 4.53], t(2068) = -0.76, p = 0.449; Std.
## beta = -0.35, 95% CI [-1.27, 0.56])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-3.54, 5.75], t(2068) = 0.47, p = 0.641; Std.
## beta = 0.14, 95% CI [-0.44, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.18, 95% CI [0.12, 18.23], t(2068) = 1.99, p = 0.047; Std.
## beta = 1.14, 95% CI [0.01, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.95, 95% CI [-0.83, 10.72], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.61, 95% CI [-0.10, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-7.19, 3.96], t(2068) = -0.57, p = 0.569; Std.
## beta = -0.20, 95% CI [-0.89, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-5.95, 1.44], t(2068) = -1.20, p = 0.231; Std.
## beta = -0.28, 95% CI [-0.74, 0.18])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.47, 95% CI [-49.94, -9.01], t(2068) = -2.83, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-6.53, 11.47], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.31, 95% CI [-0.81, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-9.32, 16.78], t(2068) = 0.56, p = 0.575; Std.
## beta = 0.46, 95% CI [-1.15, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-14.33, 8.91], t(2068) = -0.46, p = 0.648; Std.
## beta = -0.34, 95% CI [-1.77, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.34. The model's intercept, corresponding to site =
## Simmons, is at 46.46 (95% CI [41.30, 51.61], t(2068) = 17.68, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-9.09, -4.24], t(2068) = -5.39, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.44])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.85, 95% CI [-3.28, -0.42], t(2068) = -2.54, p = 0.011; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-28.11, 25.00], t(2068) = -0.11, p = 0.908; Std. beta = -3.70,
## 95% CI [-7.10, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.02, 95% CI [5.68, 44.36], t(2068) = 2.54, p = 0.011; Std. beta = 1.58, 95%
## CI [0.32, 2.85])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-24.51, 11.77], t(2068) = -0.69, p = 0.491; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-28.46, 1.91], t(2068) = -1.71, p = 0.087; Std. beta = -1.25,
## 95% CI [-2.74, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.93, 95% CI [-11.11, 26.97], t(2068) = 0.82, p = 0.414; Std. beta = 0.73,
## 95% CI [-0.65, 2.10])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.52, 95% CI [-2.74, 11.79], t(2068) = 1.22, p = 0.222; Std. beta = 0.06, 95%
## CI [-0.41, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.61, 95% CI [-28.04, 8.83], t(2068) = -1.02, p = 0.307; Std. beta = -0.55,
## 95% CI [-1.82, 0.71])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.77, 95% CI [13.70, 23.85], t(2068) = 7.25, p < .001; Std. beta = 1.22, 95%
## CI [0.88, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.03, 95% CI [-1.65, 17.71], t(2068) = 1.63, p = 0.104; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-6.29, 2.16], t(2068) = -0.96, p = 0.338; Std. beta = -0.02,
## 95% CI [-0.30, 0.27])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.81, 95% CI [-20.99, -0.62], t(2068) = -2.08, p = 0.038; Std. beta = -0.51,
## 95% CI [-1.37, 0.35])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-3.39, 6.33], t(2068) = 0.59, p = 0.554; Std. beta = 0.08, 95%
## CI [-0.24, 0.40])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-10.68, 2.51], t(2068) = -1.21, p = 0.225; Std. beta = -0.13,
## 95% CI [-0.56, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-9.52, 28.07], t(2068) = 0.97, p = 0.333; Std. beta = -0.71,
## 95% CI [-2.33, 0.92])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-24.59, 4.93], t(2068) = -1.31, p = 0.191; Std. beta = -0.20,
## 95% CI [-1.16, 0.76])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-28.23, 24.18], t(2068) = -0.15, p = 0.880; Std. beta = -0.14,
## 95% CI [-1.92, 1.64])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.38, 95% CI [-9.89, 12.65], t(2068) = 0.24, p = 0.810; Std. beta = 0.52, 95%
## CI [-0.28, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.12, 95% CI [-29.48, 7.24], t(2068) = -1.19, p = 0.235; Std. beta = -0.57,
## 95% CI [-1.84, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-24.73, 3.84], t(2068) = -1.43, p = 0.152; Std. beta = -0.75,
## 95% CI [-1.70, 0.20])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.05, 95% CI [-37.42, 21.32], t(2068) = -0.54, p = 0.591; Std. beta = -1.63,
## 95% CI [-5.04, 1.79])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.65, 95% CI [-49.32, 4.01], t(2068) = -1.67, p = 0.096; Std. beta = -1.79,
## 95% CI [-4.41, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-20.59, 2.45], t(2068) = -1.54, p = 0.123; Std. beta = -0.71,
## 95% CI [-1.51, 0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.21, 95% CI [32.54, 85.88], t(2068) = 4.35, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.84])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-23.53, 14.19], t(2068) = -0.49, p = 0.628; Std. beta = -1.44,
## 95% CI [-3.95, 1.08])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-20.79, 3.75], t(2068) = -1.36, p = 0.173; Std. beta = -0.23,
## 95% CI [-1.28, 0.82])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.83, 95% CI [-14.74, 7.08], t(2068) = -0.69, p = 0.491; Std. beta = -0.14,
## 95% CI [-0.94, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-35.63, 14.13], t(2068) = -0.85, p = 0.397; Std. beta =
## -0.26, 95% CI [-1.84, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.23, 95% CI [-20.62, -3.84], t(2068) = -2.86, p = 0.004; Std. beta = -0.34,
## 95% CI [-0.98, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.38, 95% CI [-31.37, -7.39], t(2068) = -3.17, p = 0.002; Std. beta = -1.41,
## 95% CI [-2.56, -0.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.69, 95% CI [-9.24, 10.63], t(2068) = 0.14, p = 0.891; Std. beta = -0.26,
## 95% CI [-0.94, 0.42])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.83, 4.86], t(2068) = -1.08, p = 0.279; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.69, 95% CI [-32.16, -1.23], t(2068) = -2.12, p = 0.034; Std. beta = -2.12,
## 95% CI [-4.69, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-27.38, 24.76], t(2068) = -0.10, p = 0.922; Std. beta = -0.33,
## 95% CI [-1.93, 1.28])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.32, 95% CI [-11.62, 10.99], t(2068) = -0.06, p = 0.956; Std. beta = 0.12,
## 95% CI [-0.60, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-9.47, 16.76], t(2068) = 0.54, p = 0.586; Std. beta = 0.14, 95%
## CI [-0.78, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.64, 95% CI [-22.59, 3.31], t(2068) = -1.46, p = 0.145; Std. beta = -0.95,
## 95% CI [-1.94, 0.04])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-15.83, 3.83], t(2068) = -1.20, p = 0.232; Std. beta = -0.29,
## 95% CI [-0.97, 0.38])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.29, 95% CI [-30.69, 0.10], t(2068) = -1.95, p = 0.052; Std. beta = -0.10,
## 95% CI [-1.19, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-7.88, 15.37], t(2068) = 0.63, p = 0.528; Std. beta = 0.76, 95%
## CI [-0.06, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.77, 95% CI [-10.92, 14.46], t(2068) = 0.27, p = 0.784; Std. beta = -0.05,
## 95% CI [-0.89, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-10.04, 7.24], t(2068) = -0.32, p = 0.751; Std. beta = -0.33,
## 95% CI [-0.90, 0.24])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-21.59, 30.45], t(2068) = 0.33, p = 0.738; Std. beta = -2.73,
## 95% CI [-4.89, -0.57])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-15.69, 20.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.42,
## 95% CI [-0.89, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.81, 95% CI [-28.90, 1.27], t(2068) = -1.80, p = 0.073; Std. beta = -0.56,
## 95% CI [-1.92, 0.80])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.26, 95% CI [-17.76, -0.76], t(2068) = -2.14, p = 0.033; Std. beta = -0.91,
## 95% CI [-1.99, 0.18])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically significant
## and positive (beta = 0.72, 95% CI [0.04, 1.41], t(2068) = 2.07, p = 0.039; Std.
## beta = 0.08, 95% CI [4.29e-03, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.95, 95% CI [-71.29, 1.40], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.33, 95% CI [-8.83, 0.17])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-12.78, 10.49], t(2068) = -0.19, p = 0.847;
## Std. beta = -0.14, 95% CI [-1.58, 1.30])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.72, 10.82], t(2068) = -0.23, p = 0.817;
## Std. beta = -0.18, 95% CI [-1.70, 1.34])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.37, 95% CI [-18.18, 11.44], t(2068) = -0.45, p = 0.656;
## Std. beta = -0.42, 95% CI [-2.25, 1.42])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.14, 11.77], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.22, 95% CI [-1.01, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-5.15, 0.39], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.29, 95% CI [-0.64, 0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-7.27, 9.22], t(2068) = 0.23, p = 0.817; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-2.68, 1.58], t(2068) = -0.50, p = 0.614; Std.
## beta = -0.07, 95% CI [-0.33, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-5.60, 2.93], t(2068) = -0.61, p = 0.539; Std.
## beta = -0.17, 95% CI [-0.69, 0.36])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-0.68, 3.03], t(2068) = 1.25, p = 0.213; Std.
## beta = 0.15, 95% CI [-0.08, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.23, 95% CI [-5.07, 9.52], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.28, 95% CI [-0.63, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.19, 95% CI [-2.28, 1.89], t(2068) = -0.18, p = 0.855; Std.
## beta = -0.02, 95% CI [-0.28, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.69, 4.60], t(2068) = 0.91, p = 0.364; Std.
## beta = 0.18, 95% CI [-0.21, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.03, 95% CI [-29.03, 2.97], t(2068) = -1.60, p = 0.110;
## Std. beta = -1.61, 95% CI [-3.60, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-2.11, 11.22], t(2068) = 1.34, p = 0.180; Std.
## beta = 0.56, 95% CI [-0.26, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.11, 95% CI [-1.34, 9.56], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.51, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-6.01, 9.71], t(2068) = 0.46, p = 0.644; Std.
## beta = 0.23, 95% CI [-0.74, 1.20])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-8.12, 7.30], t(2068) = -0.10, p = 0.917; Std.
## beta = -0.05, 95% CI [-1.01, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.51, 95% CI [-56.97, 35.94], t(2068) = -0.44, p = 0.657;
## Std. beta = -1.30, 95% CI [-7.06, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-30.17, 25.33], t(2068) = -0.17, p = 0.864;
## Std. beta = -0.30, 95% CI [-3.74, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-6.04, 4.24], t(2068) = -0.34, p = 0.731; Std.
## beta = -0.11, 95% CI [-0.75, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.87, 95% CI [-36.33, 14.58], t(2068) = -0.84, p = 0.402;
## Std. beta = -1.35, 95% CI [-4.50, 1.81])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-6.15, 12.87], t(2068) = 0.69, p = 0.489; Std.
## beta = 0.42, 95% CI [-0.76, 1.59])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-5.45, 7.87], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.15, 95% CI [-0.67, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.59, 95% CI [-4.73, 13.92], t(2068) = 0.97, p = 0.334; Std.
## beta = 0.57, 95% CI [-0.59, 1.72])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.74, 95% CI [-0.71, 10.19], t(2068) = 1.70, p = 0.088; Std.
## beta = 0.59, 95% CI [-0.09, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-11.38, 9.68], t(2068) = -0.16, p = 0.874; Std.
## beta = -0.11, 95% CI [-1.41, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.86, 1.91], t(2068) = -1.19, p = 0.233; Std.
## beta = -0.37, 95% CI [-0.97, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.88, 3.74], t(2068) = -0.70, p = 0.485; Std.
## beta = -0.26, 95% CI [-0.98, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.25, 16.01], t(2068) = -0.74, p = 0.462;
## Std. beta = -1.19, 95% CI [-4.37, 1.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-12.28, 7.67], t(2068) = -0.45, p = 0.650; Std.
## beta = -0.29, 95% CI [-1.52, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.37, 95% CI [-2.46, 5.20], t(2068) = 0.70, p = 0.484; Std.
## beta = 0.17, 95% CI [-0.31, 0.64])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-7.96, 5.95], t(2068) = -0.28, p = 0.777; Std.
## beta = -0.12, 95% CI [-0.99, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-10.23, 4.53], t(2068) = -0.76, p = 0.449; Std.
## beta = -0.35, 95% CI [-1.27, 0.56])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-3.54, 5.75], t(2068) = 0.47, p = 0.641; Std.
## beta = 0.14, 95% CI [-0.44, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.18, 95% CI [0.12, 18.23], t(2068) = 1.99, p = 0.047; Std.
## beta = 1.14, 95% CI [0.01, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.95, 95% CI [-0.83, 10.72], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.61, 95% CI [-0.10, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-7.19, 3.96], t(2068) = -0.57, p = 0.569; Std.
## beta = -0.20, 95% CI [-0.89, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-5.95, 1.44], t(2068) = -1.20, p = 0.231; Std.
## beta = -0.28, 95% CI [-0.74, 0.18])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.47, 95% CI [-49.94, -9.01], t(2068) = -2.83, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-6.53, 11.47], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.31, 95% CI [-0.81, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-9.32, 16.78], t(2068) = 0.56, p = 0.575; Std.
## beta = 0.46, 95% CI [-1.15, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-14.33, 8.91], t(2068) = -0.46, p = 0.648; Std.
## beta = -0.34, 95% CI [-1.77, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to cohort = CARE-PF, is at 46.46 (95% CI [41.30, 51.61], t(2068)
## = 17.68, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -6.67, 95% CI [-9.09, -4.24], t(2068) = -5.39, p < .001; Std. beta = -0.55, 95%
## CI [-0.67, -0.44])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.85, 95% CI [-3.28, -0.42], t(2068) = -2.54, p = 0.011; Std. beta = -0.05,
## 95% CI [-0.14, 0.04])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-28.11, 25.00], t(2068) = -0.11, p = 0.908; Std. beta = -3.70,
## 95% CI [-7.10, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.02, 95% CI [5.68, 44.36], t(2068) = 2.54, p = 0.011; Std. beta = 1.58, 95%
## CI [0.32, 2.85])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -6.37, 95% CI [-24.51, 11.77], t(2068) = -0.69, p = 0.491; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.27, 95% CI [-28.46, 1.91], t(2068) = -1.71, p = 0.087; Std. beta = -1.25,
## 95% CI [-2.74, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 7.93, 95% CI [-11.11, 26.97], t(2068) = 0.82, p = 0.414; Std. beta = 0.73,
## 95% CI [-0.65, 2.10])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 4.52, 95% CI [-2.74, 11.79], t(2068) = 1.22, p = 0.222; Std. beta = 0.06, 95%
## CI [-0.41, 0.53])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.61, 95% CI [-28.04, 8.83], t(2068) = -1.02, p = 0.307; Std. beta = -0.55,
## 95% CI [-1.82, 0.71])
## - The effect of site [101] is statistically significant and positive (beta =
## 18.77, 95% CI [13.70, 23.85], t(2068) = 7.25, p < .001; Std. beta = 1.22, 95%
## CI [0.88, 1.56])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.03, 95% CI [-1.65, 17.71], t(2068) = 1.63, p = 0.104; Std. beta = 0.41, 95%
## CI [-0.23, 1.05])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.06, 95% CI [-6.29, 2.16], t(2068) = -0.96, p = 0.338; Std. beta = -0.02,
## 95% CI [-0.30, 0.27])
## - The effect of site [104] is statistically significant and negative (beta =
## -10.81, 95% CI [-20.99, -0.62], t(2068) = -2.08, p = 0.038; Std. beta = -0.51,
## 95% CI [-1.37, 0.35])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.47, 95% CI [-3.39, 6.33], t(2068) = 0.59, p = 0.554; Std. beta = 0.08, 95%
## CI [-0.24, 0.40])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -4.08, 95% CI [-10.68, 2.51], t(2068) = -1.21, p = 0.225; Std. beta = -0.13,
## 95% CI [-0.56, 0.31])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.27, 95% CI [-9.52, 28.07], t(2068) = 0.97, p = 0.333; Std. beta = -0.71,
## 95% CI [-2.33, 0.92])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -9.83, 95% CI [-24.59, 4.93], t(2068) = -1.31, p = 0.191; Std. beta = -0.20,
## 95% CI [-1.16, 0.76])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -2.02, 95% CI [-28.23, 24.18], t(2068) = -0.15, p = 0.880; Std. beta = -0.14,
## 95% CI [-1.92, 1.64])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.38, 95% CI [-9.89, 12.65], t(2068) = 0.24, p = 0.810; Std. beta = 0.52, 95%
## CI [-0.28, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -11.12, 95% CI [-29.48, 7.24], t(2068) = -1.19, p = 0.235; Std. beta = -0.57,
## 95% CI [-1.84, 0.70])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.45, 95% CI [-24.73, 3.84], t(2068) = -1.43, p = 0.152; Std. beta = -0.75,
## 95% CI [-1.70, 0.20])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -8.05, 95% CI [-37.42, 21.32], t(2068) = -0.54, p = 0.591; Std. beta = -1.63,
## 95% CI [-5.04, 1.79])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.65, 95% CI [-49.32, 4.01], t(2068) = -1.67, p = 0.096; Std. beta = -1.79,
## 95% CI [-4.41, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -9.07, 95% CI [-20.59, 2.45], t(2068) = -1.54, p = 0.123; Std. beta = -0.71,
## 95% CI [-1.51, 0.09])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.21, 95% CI [32.54, 85.88], t(2068) = 4.35, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.84])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-23.53, 14.19], t(2068) = -0.49, p = 0.628; Std. beta = -1.44,
## 95% CI [-3.95, 1.08])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -8.52, 95% CI [-20.79, 3.75], t(2068) = -1.36, p = 0.173; Std. beta = -0.23,
## 95% CI [-1.28, 0.82])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.83, 95% CI [-14.74, 7.08], t(2068) = -0.69, p = 0.491; Std. beta = -0.14,
## 95% CI [-0.94, 0.67])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.75, 95% CI [-35.63, 14.13], t(2068) = -0.85, p = 0.397; Std. beta =
## -0.26, 95% CI [-1.84, 1.32])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.23, 95% CI [-20.62, -3.84], t(2068) = -2.86, p = 0.004; Std. beta = -0.34,
## 95% CI [-0.98, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -19.38, 95% CI [-31.37, -7.39], t(2068) = -3.17, p = 0.002; Std. beta = -1.41,
## 95% CI [-2.56, -0.25])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.69, 95% CI [-9.24, 10.63], t(2068) = 0.14, p = 0.891; Std. beta = -0.26,
## 95% CI [-0.94, 0.42])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-16.83, 4.86], t(2068) = -1.08, p = 0.279; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.69, 95% CI [-32.16, -1.23], t(2068) = -2.12, p = 0.034; Std. beta = -2.12,
## 95% CI [-4.69, 0.44])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -1.31, 95% CI [-27.38, 24.76], t(2068) = -0.10, p = 0.922; Std. beta = -0.33,
## 95% CI [-1.93, 1.28])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.32, 95% CI [-11.62, 10.99], t(2068) = -0.06, p = 0.956; Std. beta = 0.12,
## 95% CI [-0.60, 0.83])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-9.47, 16.76], t(2068) = 0.54, p = 0.586; Std. beta = 0.14, 95%
## CI [-0.78, 1.07])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -9.64, 95% CI [-22.59, 3.31], t(2068) = -1.46, p = 0.145; Std. beta = -0.95,
## 95% CI [-1.94, 0.04])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-15.83, 3.83], t(2068) = -1.20, p = 0.232; Std. beta = -0.29,
## 95% CI [-0.97, 0.38])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -15.29, 95% CI [-30.69, 0.10], t(2068) = -1.95, p = 0.052; Std. beta = -0.10,
## 95% CI [-1.19, 1.00])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.75, 95% CI [-7.88, 15.37], t(2068) = 0.63, p = 0.528; Std. beta = 0.76, 95%
## CI [-0.06, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.77, 95% CI [-10.92, 14.46], t(2068) = 0.27, p = 0.784; Std. beta = -0.05,
## 95% CI [-0.89, 0.79])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.40, 95% CI [-10.04, 7.24], t(2068) = -0.32, p = 0.751; Std. beta = -0.33,
## 95% CI [-0.90, 0.24])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 4.43, 95% CI [-21.59, 30.45], t(2068) = 0.33, p = 0.738; Std. beta = -2.73,
## 95% CI [-4.89, -0.57])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 2.47, 95% CI [-15.69, 20.62], t(2068) = 0.27, p = 0.790; Std. beta = 0.42,
## 95% CI [-0.89, 1.74])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.81, 95% CI [-28.90, 1.27], t(2068) = -1.80, p = 0.073; Std. beta = -0.56,
## 95% CI [-1.92, 0.80])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.26, 95% CI [-17.76, -0.76], t(2068) = -2.14, p = 0.033; Std. beta = -0.91,
## 95% CI [-1.99, 0.18])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically significant
## and positive (beta = 0.72, 95% CI [0.04, 1.41], t(2068) = 2.07, p = 0.039; Std.
## beta = 0.08, 95% CI [4.29e-03, 0.16])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.95, 95% CI [-71.29, 1.40], t(2068) = -1.89, p = 0.059;
## Std. beta = -4.33, 95% CI [-8.83, 0.17])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-12.78, 10.49], t(2068) = -0.19, p = 0.847;
## Std. beta = -0.14, 95% CI [-1.58, 1.30])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -1.45, 95% CI [-13.72, 10.82], t(2068) = -0.23, p = 0.817;
## Std. beta = -0.18, 95% CI [-1.70, 1.34])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.37, 95% CI [-18.18, 11.44], t(2068) = -0.45, p = 0.656;
## Std. beta = -0.42, 95% CI [-2.25, 1.42])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-8.14, 11.77], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.22, 95% CI [-1.01, 1.46])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.38, 95% CI [-5.15, 0.39], t(2068) = -1.68, p = 0.092; Std.
## beta = -0.29, 95% CI [-0.64, 0.05])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.97, 95% CI [-7.27, 9.22], t(2068) = 0.23, p = 0.817; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.55, 95% CI [-2.68, 1.58], t(2068) = -0.50, p = 0.614; Std.
## beta = -0.07, 95% CI [-0.33, 0.20])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.33, 95% CI [-5.60, 2.93], t(2068) = -0.61, p = 0.539; Std.
## beta = -0.17, 95% CI [-0.69, 0.36])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.18, 95% CI [-0.68, 3.03], t(2068) = 1.25, p = 0.213; Std.
## beta = 0.15, 95% CI [-0.08, 0.38])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.23, 95% CI [-5.07, 9.52], t(2068) = 0.60, p = 0.550; Std.
## beta = 0.28, 95% CI [-0.63, 1.18])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.19, 95% CI [-2.28, 1.89], t(2068) = -0.18, p = 0.855; Std.
## beta = -0.02, 95% CI [-0.28, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.46, 95% CI [-1.69, 4.60], t(2068) = 0.91, p = 0.364; Std.
## beta = 0.18, 95% CI [-0.21, 0.57])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.03, 95% CI [-29.03, 2.97], t(2068) = -1.60, p = 0.110;
## Std. beta = -1.61, 95% CI [-3.60, 0.37])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.56, 95% CI [-2.11, 11.22], t(2068) = 1.34, p = 0.180; Std.
## beta = 0.56, 95% CI [-0.26, 1.39])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.11, 95% CI [-1.34, 9.56], t(2068) = 1.48, p = 0.140; Std.
## beta = 0.51, 95% CI [-0.17, 1.18])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.85, 95% CI [-6.01, 9.71], t(2068) = 0.46, p = 0.644; Std.
## beta = 0.23, 95% CI [-0.74, 1.20])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.41, 95% CI [-8.12, 7.30], t(2068) = -0.10, p = 0.917; Std.
## beta = -0.05, 95% CI [-1.01, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.51, 95% CI [-56.97, 35.94], t(2068) = -0.44, p = 0.657;
## Std. beta = -1.30, 95% CI [-7.06, 4.45])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.42, 95% CI [-30.17, 25.33], t(2068) = -0.17, p = 0.864;
## Std. beta = -0.30, 95% CI [-3.74, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -0.90, 95% CI [-6.04, 4.24], t(2068) = -0.34, p = 0.731; Std.
## beta = -0.11, 95% CI [-0.75, 0.53])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.87, 95% CI [-36.33, 14.58], t(2068) = -0.84, p = 0.402;
## Std. beta = -1.35, 95% CI [-4.50, 1.81])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.36, 95% CI [-6.15, 12.87], t(2068) = 0.69, p = 0.489; Std.
## beta = 0.42, 95% CI [-0.76, 1.59])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.21, 95% CI [-5.45, 7.87], t(2068) = 0.36, p = 0.721; Std.
## beta = 0.15, 95% CI [-0.67, 0.98])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.59, 95% CI [-4.73, 13.92], t(2068) = 0.97, p = 0.334; Std.
## beta = 0.57, 95% CI [-0.59, 1.72])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.74, 95% CI [-0.71, 10.19], t(2068) = 1.70, p = 0.088; Std.
## beta = 0.59, 95% CI [-0.09, 1.26])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -0.85, 95% CI [-11.38, 9.68], t(2068) = -0.16, p = 0.874; Std.
## beta = -0.11, 95% CI [-1.41, 1.20])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.97, 95% CI [-7.86, 1.91], t(2068) = -1.19, p = 0.233; Std.
## beta = -0.37, 95% CI [-0.97, 0.24])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.07, 95% CI [-7.88, 3.74], t(2068) = -0.70, p = 0.485; Std.
## beta = -0.26, 95% CI [-0.98, 0.46])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.62, 95% CI [-35.25, 16.01], t(2068) = -0.74, p = 0.462;
## Std. beta = -1.19, 95% CI [-4.37, 1.98])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.31, 95% CI [-12.28, 7.67], t(2068) = -0.45, p = 0.650; Std.
## beta = -0.29, 95% CI [-1.52, 0.95])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.37, 95% CI [-2.46, 5.20], t(2068) = 0.70, p = 0.484; Std.
## beta = 0.17, 95% CI [-0.31, 0.64])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.00, 95% CI [-7.96, 5.95], t(2068) = -0.28, p = 0.777; Std.
## beta = -0.12, 95% CI [-0.99, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -2.85, 95% CI [-10.23, 4.53], t(2068) = -0.76, p = 0.449; Std.
## beta = -0.35, 95% CI [-1.27, 0.56])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.11, 95% CI [-3.54, 5.75], t(2068) = 0.47, p = 0.641; Std.
## beta = 0.14, 95% CI [-0.44, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.18, 95% CI [0.12, 18.23], t(2068) = 1.99, p = 0.047; Std.
## beta = 1.14, 95% CI [0.01, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.95, 95% CI [-0.83, 10.72], t(2068) = 1.68, p = 0.093; Std.
## beta = 0.61, 95% CI [-0.10, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-7.19, 3.96], t(2068) = -0.57, p = 0.569; Std.
## beta = -0.20, 95% CI [-0.89, 0.49])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.26, 95% CI [-5.95, 1.44], t(2068) = -1.20, p = 0.231; Std.
## beta = -0.28, 95% CI [-0.74, 0.18])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.47, 95% CI [-49.94, -9.01], t(2068) = -2.83, p = 0.005;
## Std. beta = -3.65, 95% CI [-6.19, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-6.53, 11.47], t(2068) = 0.54, p = 0.590; Std.
## beta = 0.31, 95% CI [-0.81, 1.42])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.73, 95% CI [-9.32, 16.78], t(2068) = 0.56, p = 0.575; Std.
## beta = 0.46, 95% CI [-1.15, 2.08])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.71, 95% CI [-14.33, 8.91], t(2068) = -0.46, p = 0.648; Std.
## beta = -0.34, 95% CI [-1.77, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*OM_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14891.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1226 -0.4945 -0.0112 0.4428 7.0984
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 137.62 11.731
## time_firstPFT 11.01 3.318 -0.27
## Residual 41.83 6.468
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 42.15949 5.28601 7.976
## time_firstPFT -4.40274 2.40883 -1.828
## OM_5yrPreCensor -1.54872 0.74625 -2.075
## disadv -4.92708 2.33876 -2.107
## dich_RaceNon-White -2.66593 2.28326 -1.168
## sexF -2.40303 1.41252 -1.701
## age_dx 0.14562 0.07392 1.970
## smokeHxFormer -2.91205 1.40596 -2.071
## smokeHxAlways 8.05448 7.06852 1.139
## smokeHxUnknown -2.78246 3.17238 -0.877
## site02R -5.22876 13.44365 -0.389
## site03R 20.72100 9.86341 2.101
## site04R -5.80880 9.14723 -0.635
## site05R -13.61443 7.69440 -1.769
## site06R -5.45932 13.50046 -0.404
## site07R 2.86625 3.70041 0.775
## site09R -11.54038 9.32846 -1.237
## site101 19.06050 2.60575 7.315
## site102 7.21156 4.93971 1.460
## site103 -1.92222 2.25403 -0.853
## site104 -9.68285 5.18403 -1.868
## site105 2.04852 2.49237 0.822
## site106 -5.98792 3.40459 -1.759
## site107 7.12369 9.50775 0.749
## site108 -4.67013 7.82042 -0.597
## site10R -0.95544 13.39685 -0.071
## site11R -0.12395 5.71160 -0.022
## site12R -9.45205 9.27026 -1.020
## site13R -11.89982 7.24694 -1.642
## site14R -9.65322 14.93378 -0.646
## site15R -19.46876 13.49717 -1.442
## site16R -8.69172 5.90587 -1.472
## site17R 63.79100 13.57895 4.698
## site18R -3.36873 9.55854 -0.352
## site19R -9.34845 6.25654 -1.494
## site20R -3.96010 5.52198 -0.717
## site21R -10.76432 12.53059 -0.859
## site22R -14.67884 4.31235 -3.404
## site23R -25.87377 7.66811 -3.374
## site24R 0.46376 5.02017 0.092
## site25R -8.53903 5.54698 -1.539
## site28R -15.49700 7.85476 -1.973
## site29R -4.41885 13.18388 -0.335
## site31R -0.80908 5.76534 -0.140
## site32R 3.88477 6.67232 0.582
## site33R -10.08301 6.56997 -1.535
## site34R -5.86651 4.97291 -1.180
## site35R -15.77294 7.81174 -2.019
## site36R 3.16965 5.89696 0.538
## site37R -0.15021 6.49674 -0.023
## site38R -0.92810 4.36927 -0.212
## site39R 12.25347 13.37192 0.916
## site40R 0.65320 9.18138 0.071
## site41R -14.72390 7.67882 -1.917
## site42R -11.03463 4.34468 -2.540
## time_firstPFT:OM_5yrPreCensor 0.57639 0.36336 1.586
## time_firstPFT:disadv 1.20775 1.12118 1.077
## time_firstPFT:dich_RaceNon-White -0.62997 1.10587 -0.570
## time_firstPFT:sexF 0.64603 0.65747 0.983
## time_firstPFT:age_dx -0.04186 0.03429 -1.221
## time_firstPFT:smokeHxFormer -0.58350 0.67200 -0.868
## time_firstPFT:smokeHxAlways -5.54422 6.06542 -0.914
## time_firstPFT:smokeHxUnknown 2.10275 1.66853 1.260
## time_firstPFT:site02R -33.27501 18.55664 -1.793
## time_firstPFT:site03R -0.67833 5.97701 -0.113
## time_firstPFT:site04R -2.14976 6.29422 -0.342
## time_firstPFT:site05R -3.18733 7.57084 -0.421
## time_firstPFT:site07R -1.82564 1.45578 -1.254
## time_firstPFT:site09R 2.01078 4.23636 0.475
## time_firstPFT:site101 -0.41955 1.11273 -0.377
## time_firstPFT:site102 -0.79575 2.20132 -0.361
## time_firstPFT:site103 1.54987 1.00255 1.546
## time_firstPFT:site104 1.96754 3.77921 0.521
## time_firstPFT:site105 -0.07412 1.07771 -0.069
## time_firstPFT:site106 2.03116 1.65057 1.231
## time_firstPFT:site107 -12.26371 8.17154 -1.501
## time_firstPFT:site108 5.20503 3.59758 1.447
## time_firstPFT:site11R 5.02456 2.84369 1.767
## time_firstPFT:site12R 2.26986 4.03370 0.563
## time_firstPFT:site13R -0.33391 3.96917 -0.084
## time_firstPFT:site14R -9.48922 23.70981 -0.400
## time_firstPFT:site15R -2.53104 14.16914 -0.179
## time_firstPFT:site16R -1.06757 2.67752 -0.399
## time_firstPFT:site18R -10.58074 12.99781 -0.814
## time_firstPFT:site19R 3.25827 4.91870 0.662
## time_firstPFT:site20R 1.00783 3.44088 0.293
## time_firstPFT:site21R 5.35895 4.76785 1.124
## time_firstPFT:site22R 5.91879 2.82953 2.092
## time_firstPFT:site23R 23.93008 26.74263 0.895
## time_firstPFT:site24R -2.71693 2.50222 -1.086
## time_firstPFT:site25R -1.06243 3.01946 -0.352
## time_firstPFT:site28R -8.63198 13.15345 -0.656
## time_firstPFT:site29R -0.88709 5.12127 -0.173
## time_firstPFT:site31R 2.07400 2.00175 1.036
## time_firstPFT:site32R -0.42772 3.58694 -0.119
## time_firstPFT:site33R -3.27408 3.83447 -0.854
## time_firstPFT:site34R 1.27510 2.41701 0.528
## time_firstPFT:site35R 9.95497 4.67410 2.130
## time_firstPFT:site36R 5.09855 2.97061 1.716
## time_firstPFT:site37R -1.10549 2.94749 -0.375
## time_firstPFT:site38R -2.09082 1.89919 -1.101
## time_firstPFT:site39R -29.62886 10.51365 -2.818
## time_firstPFT:site40R 2.15269 4.66445 0.462
## time_firstPFT:site41R 4.66872 6.68035 0.699
## time_firstPFT:site42R -3.07898 5.94870 -0.518##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.800
## Unadjusted ICC: 0.524report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## OM_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 42.16 (95% CI [31.79, 52.53], t(2038)
## = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## OM_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to
## OM_5yrPreCensor = 0, is at 42.16 (95% CI [31.79, 52.53], t(2038) = 7.98, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to disadv = 0, is at 42.16 (95% CI [31.79,
## 52.53], t(2038) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to dich_Race =
## White, is at 42.16 (95% CI [31.79, 52.53], t(2038) = 7.98, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 42.16 (95% CI [31.79,
## 52.53], t(2038) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to age_dx = 0, is at 42.16 (95% CI [31.79,
## 52.53], t(2038) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to smokeHx =
## Never, is at 42.16 (95% CI [31.79, 52.53], t(2038) = 7.98, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 42.16 (95% CI [31.79,
## 52.53], t(2038) = 7.98, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * OM_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 42.16 (95% CI [31.79, 52.53], t(2038) = 7.98, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -4.40, 95% CI [-9.13, 0.32], t(2038) = -1.83, p = 0.068; Std. beta =
## -0.56, 95% CI [-0.75, -0.38])
## - The effect of OM 5yrPreCensor is statistically significant and negative (beta
## = -1.55, 95% CI [-3.01, -0.09], t(2038) = -2.08, p = 0.038; Std. beta = -0.04,
## 95% CI [-0.13, 0.05])
## - The effect of disadv is statistically significant and negative (beta = -4.93,
## 95% CI [-9.51, -0.34], t(2038) = -2.11, p = 0.035; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-7.14, 1.81], t(2038) = -1.17, p = 0.243; Std.
## beta = -0.25, 95% CI [-0.56, 0.07])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.40, 95% CI [-5.17, 0.37], t(2038) = -1.70, p = 0.089; Std. beta = -0.10, 95%
## CI [-0.29, 0.10])
## - The effect of age dx is statistically significant and positive (beta = 0.15,
## 95% CI [6.53e-04, 0.29], t(2038) = 1.97, p = 0.049; Std. beta = 0.05, 95% CI
## [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.91, 95% CI [-5.67, -0.15], t(2038) = -2.07, p = 0.038; Std. beta =
## -0.26, 95% CI [-0.45, -0.07])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 8.05, 95% CI [-5.81, 21.92], t(2038) = 1.14, p = 0.255; Std. beta =
## -0.02, 95% CI [-1.28, 1.24])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.78, 95% CI [-9.00, 3.44], t(2038) = -0.88, p = 0.381; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.23, 95% CI [-31.59, 21.14], t(2038) = -0.39, p = 0.697; Std. beta = -3.79,
## 95% CI [-7.20, -0.37])
## - The effect of site [03R] is statistically significant and positive (beta =
## 20.72, 95% CI [1.38, 40.06], t(2038) = 2.10, p = 0.036; Std. beta = 1.34, 95%
## CI [0.06, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -5.81, 95% CI [-23.75, 12.13], t(2038) = -0.64, p = 0.525; Std. beta = -0.62,
## 95% CI [-2.06, 0.83])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.70, 1.48], t(2038) = -1.77, p = 0.077; Std. beta = -1.25,
## 95% CI [-2.75, 0.24])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -5.46, 95% CI [-31.94, 21.02], t(2038) = -0.40, p = 0.686; Std. beta = -0.37,
## 95% CI [-2.17, 1.43])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 2.87, 95% CI [-4.39, 10.12], t(2038) = 0.77, p = 0.439; Std. beta = 6.48e-03,
## 95% CI [-0.47, 0.48])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.54, 95% CI [-29.83, 6.75], t(2038) = -1.24, p = 0.216; Std. beta = -0.58,
## 95% CI [-1.85, 0.70])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.06, 95% CI [13.95, 24.17], t(2038) = 7.31, p < .001; Std. beta = 1.25, 95%
## CI [0.90, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.21, 95% CI [-2.48, 16.90], t(2038) = 1.46, p = 0.144; Std. beta = 0.41, 95%
## CI [-0.24, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.92, 95% CI [-6.34, 2.50], t(2038) = -0.85, p = 0.394; Std. beta = 0.03,
## 95% CI [-0.27, 0.33])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.68, 95% CI [-19.85, 0.48], t(2038) = -1.87, p = 0.062; Std. beta = -0.46,
## 95% CI [-1.33, 0.42])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.05, 95% CI [-2.84, 6.94], t(2038) = 0.82, p = 0.411; Std. beta = 0.13, 95%
## CI [-0.20, 0.46])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.99, 95% CI [-12.66, 0.69], t(2038) = -1.76, p = 0.079; Std. beta = -0.20,
## 95% CI [-0.65, 0.25])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.12, 95% CI [-11.52, 25.77], t(2038) = 0.75, p = 0.454; Std. beta = -0.78,
## 95% CI [-2.41, 0.85])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -4.67, 95% CI [-20.01, 10.67], t(2038) = -0.60, p = 0.550; Std. beta = 0.22,
## 95% CI [-0.80, 1.24])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.96, 95% CI [-27.23, 25.32], t(2038) = -0.07, p = 0.943; Std. beta = -0.06,
## 95% CI [-1.85, 1.72])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.12, 95% CI [-11.33, 11.08], t(2038) = -0.02, p = 0.983; Std. beta = 0.51,
## 95% CI [-0.29, 1.31])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.45, 95% CI [-27.63, 8.73], t(2038) = -1.02, p = 0.308; Std. beta = -0.41,
## 95% CI [-1.68, 0.87])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.11, 2.31], t(2038) = -1.64, p = 0.101; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.65, 95% CI [-38.94, 19.63], t(2038) = -0.65, p = 0.518; Std. beta = -1.63,
## 95% CI [-5.07, 1.80])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.47, 95% CI [-45.94, 7.00], t(2038) = -1.44, p = 0.149; Std. beta = -1.58,
## 95% CI [-4.22, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.69, 95% CI [-20.27, 2.89], t(2038) = -1.47, p = 0.141; Std. beta = -0.70,
## 95% CI [-1.52, 0.12])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.79, 95% CI [37.16, 90.42], t(2038) = 4.70, p < .001; Std. beta = 4.33, 95%
## CI [2.53, 6.14])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -3.37, 95% CI [-22.11, 15.38], t(2038) = -0.35, p = 0.725; Std. beta = -1.32,
## 95% CI [-3.85, 1.21])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -9.35, 95% CI [-21.62, 2.92], t(2038) = -1.49, p = 0.135; Std. beta = -0.30,
## 95% CI [-1.37, 0.77])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.96, 95% CI [-14.79, 6.87], t(2038) = -0.72, p = 0.473; Std. beta = -0.17,
## 95% CI [-0.98, 0.65])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -10.76, 95% CI [-35.34, 13.81], t(2038) = -0.86, p = 0.390; Std. beta =
## -0.18, 95% CI [-1.76, 1.40])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.68, 95% CI [-23.14, -6.22], t(2038) = -3.40, p < .001; Std. beta = -0.39,
## 95% CI [-1.04, 0.26])
## - The effect of site [23R] is statistically significant and negative (beta =
## -25.87, 95% CI [-40.91, -10.84], t(2038) = -3.37, p < .001; Std. beta = 0.71,
## 95% CI [-4.28, 5.70])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 0.46, 95% CI [-9.38, 10.31], t(2038) = 0.09, p = 0.926; Std. beta = -0.25,
## 95% CI [-0.93, 0.43])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.54, 95% CI [-19.42, 2.34], t(2038) = -1.54, p = 0.124; Std. beta = -0.69,
## 95% CI [-1.45, 0.07])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.50, 95% CI [-30.90, -0.09], t(2038) = -1.97, p = 0.049; Std. beta = -1.94,
## 95% CI [-4.54, 0.65])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -4.42, 95% CI [-30.27, 21.44], t(2038) = -0.34, p = 0.738; Std. beta = -0.39,
## 95% CI [-2.00, 1.22])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.81, 95% CI [-12.12, 10.50], t(2038) = -0.14, p = 0.888; Std. beta = 0.16,
## 95% CI [-0.57, 0.88])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 3.88, 95% CI [-9.20, 16.97], t(2038) = 0.58, p = 0.560; Std. beta = 0.22, 95%
## CI [-0.71, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -10.08, 95% CI [-22.97, 2.80], t(2038) = -1.53, p = 0.125; Std. beta = -1.02,
## 95% CI [-2.02, -0.02])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.87, 95% CI [-15.62, 3.89], t(2038) = -1.18, p = 0.238; Std. beta = -0.27,
## 95% CI [-0.94, 0.41])
## - The effect of site [35R] is statistically significant and negative (beta =
## -15.77, 95% CI [-31.09, -0.45], t(2038) = -2.02, p = 0.044; Std. beta = -0.05,
## 95% CI [-1.15, 1.06])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.17, 95% CI [-8.40, 14.73], t(2038) = 0.54, p = 0.591; Std. beta = 0.74, 95%
## CI [-0.09, 1.57])
## - The effect of site [37R] is statistically non-significant and negative (beta
## = -0.15, 95% CI [-12.89, 12.59], t(2038) = -0.02, p = 0.982; Std. beta = -0.12,
## 95% CI [-0.98, 0.73])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.93, 95% CI [-9.50, 7.64], t(2038) = -0.21, p = 0.832; Std. beta = -0.28,
## 95% CI [-0.85, 0.29])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 12.25, 95% CI [-13.97, 38.48], t(2038) = 0.92, p = 0.360; Std. beta = -2.22,
## 95% CI [-4.41, -0.03])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 0.65, 95% CI [-17.35, 18.66], t(2038) = 0.07, p = 0.943; Std. beta = 0.27,
## 95% CI [-1.06, 1.59])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -14.72, 95% CI [-29.78, 0.34], t(2038) = -1.92, p = 0.055; Std. beta = -0.52,
## 95% CI [-1.89, 0.85])
## - The effect of site [42R] is statistically significant and negative (beta =
## -11.03, 95% CI [-19.56, -2.51], t(2038) = -2.54, p = 0.011; Std. beta = -1.07,
## 95% CI [-2.16, 0.03])
## - The effect of time firstPFT × OM 5yrPreCensor is statistically
## non-significant and positive (beta = 0.58, 95% CI [-0.14, 1.29], t(2038) =
## 1.59, p = 0.113; Std. beta = 0.06, 95% CI [-0.02, 0.15])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.21, 95% CI [-0.99, 3.41], t(2038) = 1.08, p = 0.282; Std.
## beta = 0.04, 95% CI [-0.03, 0.12])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.63, 95% CI [-2.80, 1.54], t(2038) =
## -0.57, p = 0.569; Std. beta = -0.08, 95% CI [-0.35, 0.19])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.65, 95% CI [-0.64, 1.94], t(2038) = 0.98, p = 0.326; Std.
## beta = 0.08, 95% CI [-0.08, 0.24])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.22, p = 0.222; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-1.90, 0.73], t(2038) =
## -0.87, p = 0.385; Std. beta = -0.07, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -5.54, 95% CI [-17.44, 6.35], t(2038) =
## -0.91, p = 0.361; Std. beta = -0.69, 95% CI [-2.16, 0.79])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.10, 95% CI [-1.17, 5.37], t(2038) =
## 1.26, p = 0.208; Std. beta = 0.26, 95% CI [-0.15, 0.67])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.28, 95% CI [-69.67, 3.12], t(2038) = -1.79, p = 0.073;
## Std. beta = -4.13, 95% CI [-8.64, 0.39])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.68, 95% CI [-12.40, 11.04], t(2038) = -0.11, p = 0.910;
## Std. beta = -0.08, 95% CI [-1.54, 1.37])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-14.49, 10.19], t(2038) = -0.34, p = 0.733;
## Std. beta = -0.27, 95% CI [-1.80, 1.26])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.19, 95% CI [-18.03, 11.66], t(2038) = -0.42, p = 0.674;
## Std. beta = -0.40, 95% CI [-2.24, 1.45])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -1.83, 95% CI [-4.68, 1.03], t(2038) = -1.25, p = 0.210; Std.
## beta = -0.23, 95% CI [-0.58, 0.13])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.01, 95% CI [-6.30, 10.32], t(2038) = 0.47, p = 0.635; Std.
## beta = 0.25, 95% CI [-0.78, 1.28])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.42, 95% CI [-2.60, 1.76], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.05, 95% CI [-0.32, 0.22])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.80, 95% CI [-5.11, 3.52], t(2038) = -0.36, p = 0.718; Std.
## beta = -0.10, 95% CI [-0.63, 0.44])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.55, 95% CI [-0.42, 3.52], t(2038) = 1.55, p = 0.122; Std.
## beta = 0.19, 95% CI [-0.05, 0.44])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.97, 95% CI [-5.44, 9.38], t(2038) = 0.52, p = 0.603; Std.
## beta = 0.24, 95% CI [-0.68, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.07, 95% CI [-2.19, 2.04], t(2038) = -0.07, p = 0.945; Std.
## beta = -9.20e-03, 95% CI [-0.27, 0.25])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 2.03, 95% CI [-1.21, 5.27], t(2038) = 1.23, p = 0.219; Std.
## beta = 0.25, 95% CI [-0.15, 0.65])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.26, 95% CI [-28.29, 3.76], t(2038) = -1.50, p = 0.134;
## Std. beta = -1.52, 95% CI [-3.51, 0.47])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 5.21, 95% CI [-1.85, 12.26], t(2038) = 1.45, p = 0.148; Std.
## beta = 0.65, 95% CI [-0.23, 1.52])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.55, 10.60], t(2038) = 1.77, p = 0.077; Std.
## beta = 0.62, 95% CI [-0.07, 1.32])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 2.27, 95% CI [-5.64, 10.18], t(2038) = 0.56, p = 0.574; Std.
## beta = 0.28, 95% CI [-0.70, 1.26])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.33, 95% CI [-8.12, 7.45], t(2038) = -0.08, p = 0.933; Std.
## beta = -0.04, 95% CI [-1.01, 0.92])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.49, 95% CI [-55.99, 37.01], t(2038) = -0.40, p = 0.689;
## Std. beta = -1.18, 95% CI [-6.95, 4.59])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.53, 95% CI [-30.32, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.31, 95% CI [-3.76, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.07, 95% CI [-6.32, 4.18], t(2038) = -0.40, p = 0.690; Std.
## beta = -0.13, 95% CI [-0.78, 0.52])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -10.58, 95% CI [-36.07, 14.91], t(2038) = -0.81, p = 0.416;
## Std. beta = -1.31, 95% CI [-4.48, 1.85])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 3.26, 95% CI [-6.39, 12.90], t(2038) = 0.66, p = 0.508; Std.
## beta = 0.40, 95% CI [-0.79, 1.60])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-5.74, 7.76], t(2038) = 0.29, p = 0.770; Std.
## beta = 0.13, 95% CI [-0.71, 0.96])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.36, 95% CI [-3.99, 14.71], t(2038) = 1.12, p = 0.261; Std.
## beta = 0.66, 95% CI [-0.50, 1.83])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.92, 95% CI [0.37, 11.47], t(2038) = 2.09, p = 0.037; Std.
## beta = 0.73, 95% CI [0.05, 1.42])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 23.93, 95% CI [-28.52, 76.38], t(2038) = 0.89, p = 0.371; Std.
## beta = 2.97, 95% CI [-3.54, 9.48])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -2.72, 95% CI [-7.62, 2.19], t(2038) = -1.09, p = 0.278; Std.
## beta = -0.34, 95% CI [-0.95, 0.27])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.98, 4.86], t(2038) = -0.35, p = 0.725; Std.
## beta = -0.13, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.63, 95% CI [-34.43, 17.16], t(2038) = -0.66, p = 0.512;
## Std. beta = -1.07, 95% CI [-4.27, 2.13])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -0.89, 95% CI [-10.93, 9.16], t(2038) = -0.17, p = 0.862; Std.
## beta = -0.11, 95% CI [-1.36, 1.14])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-1.85, 6.00], t(2038) = 1.04, p = 0.300; Std.
## beta = 0.26, 95% CI [-0.23, 0.74])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -0.43, 95% CI [-7.46, 6.61], t(2038) = -0.12, p = 0.905; Std.
## beta = -0.05, 95% CI [-0.93, 0.82])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -3.27, 95% CI [-10.79, 4.25], t(2038) = -0.85, p = 0.393; Std.
## beta = -0.41, 95% CI [-1.34, 0.53])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.28, 95% CI [-3.46, 6.02], t(2038) = 0.53, p = 0.598; Std.
## beta = 0.16, 95% CI [-0.43, 0.75])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.95, 95% CI [0.79, 19.12], t(2038) = 2.13, p = 0.033; Std.
## beta = 1.24, 95% CI [0.10, 2.37])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.73, 10.92], t(2038) = 1.72, p = 0.086; Std.
## beta = 0.63, 95% CI [-0.09, 1.36])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-6.89, 4.67], t(2038) = -0.38, p = 0.708; Std.
## beta = -0.14, 95% CI [-0.85, 0.58])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.09, 95% CI [-5.82, 1.63], t(2038) = -1.10, p = 0.271; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -29.63, 95% CI [-50.25, -9.01], t(2038) = -2.82, p = 0.005;
## Std. beta = -3.68, 95% CI [-6.23, -1.12])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 2.15, 95% CI [-6.99, 11.30], t(2038) = 0.46, p = 0.644; Std.
## beta = 0.27, 95% CI [-0.87, 1.40])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.67, 95% CI [-8.43, 17.77], t(2038) = 0.70, p = 0.485; Std.
## beta = 0.58, 95% CI [-1.05, 2.20])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-14.75, 8.59], t(2038) = -0.52, p = 0.605; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*SS_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15060.2
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1439 -0.4956 -0.0078 0.4482 7.1089
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 144.24 12.010
## time_firstPFT 11.32 3.364 -0.32
## Residual 41.81 6.466
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 41.7063 1.5192 27.453
## time_firstPFT -4.7110 0.7064 -6.669
## SS_5yrPreCensor -6.8811 5.4816 -1.255
## site02R 14.1836 18.6385 0.761
## site03R 25.5306 9.9131 2.575
## site04R -4.9274 9.2961 -0.530
## site05R -12.9412 7.7940 -1.660
## site06R 4.8776 9.6995 0.503
## site07R 5.9523 3.6964 1.610
## site09R -6.5409 9.5273 -0.687
## site101 20.6128 2.5214 8.175
## site102 8.4375 4.9861 1.692
## site103 -1.0442 2.1875 -0.477
## site104 -8.9888 5.1758 -1.737
## site105 2.1442 2.4893 0.861
## site106 -2.9907 3.3810 -0.885
## site107 11.0237 9.6182 1.146
## site108 -8.4385 7.5627 -1.116
## site10R 2.9644 15.5285 0.191
## site11R 0.4324 5.7718 0.075
## site12R -9.2972 9.3836 -0.991
## site13R -9.6907 7.3226 -1.323
## site14R -4.8894 15.0292 -0.325
## site15R -22.9730 13.6749 -1.680
## site16R -6.6642 5.9861 -1.113
## site17R 59.3076 13.6825 4.335
## site18R -2.4033 9.8103 -0.245
## site19R -5.1098 6.1269 -0.834
## site20R -3.0320 5.5889 -0.543
## site21R -12.1354 12.7560 -0.951
## site22R -9.5264 4.3709 -2.180
## site23R -17.3699 6.1873 -2.807
## site24R 2.2261 5.0496 0.441
## site25R 3.5916 9.2054 0.390
## site28R -17.0583 7.9319 -2.151
## site29R 3.5392 13.4859 0.262
## site31R 0.5544 5.7936 0.096
## site32R 5.9447 6.6748 0.891
## site33R -5.9965 6.8196 -0.879
## site34R -4.1390 5.0034 -0.827
## site35R -12.6744 7.8450 -1.616
## site36R 3.8265 5.9667 0.641
## site37R 2.6456 6.5131 0.406
## site38R -1.1645 4.4321 -0.263
## site39R 6.1463 13.3280 0.461
## site40R 3.2878 9.3691 0.351
## site41R -11.9200 7.7756 -1.533
## site42R -7.6192 4.3734 -1.742
## time_firstPFT:SS_5yrPreCensor 2.2548 2.7734 0.813
## time_firstPFT:site02R -40.0970 19.6447 -2.041
## time_firstPFT:site03R -1.3431 5.9456 -0.226
## time_firstPFT:site04R -2.0081 6.2649 -0.321
## time_firstPFT:site05R -3.5489 7.5598 -0.469
## time_firstPFT:site06R 3.0788 5.0532 0.609
## time_firstPFT:site07R -2.9126 1.4112 -2.064
## time_firstPFT:site09R 0.2561 4.2634 0.060
## time_firstPFT:site101 -1.2096 1.0672 -1.133
## time_firstPFT:site102 -1.5241 2.1925 -0.695
## time_firstPFT:site103 0.9627 0.9679 0.995
## time_firstPFT:site104 2.0685 3.7274 0.555
## time_firstPFT:site105 -0.4531 1.0713 -0.423
## time_firstPFT:site106 1.0246 1.6151 0.634
## time_firstPFT:site107 -13.7007 8.1638 -1.678
## time_firstPFT:site108 3.8889 3.4063 1.142
## time_firstPFT:site11R 4.5995 2.7876 1.650
## time_firstPFT:site12R 1.3063 4.0196 0.325
## time_firstPFT:site13R -0.7118 3.9449 -0.180
## time_firstPFT:site14R -11.6979 23.6976 -0.494
## time_firstPFT:site15R -2.2945 14.1639 -0.162
## time_firstPFT:site16R -1.7510 2.6596 -0.658
## time_firstPFT:site18R -11.7333 13.0029 -0.902
## time_firstPFT:site19R 2.1414 4.8310 0.443
## time_firstPFT:site20R 0.8507 3.4002 0.250
## time_firstPFT:site21R 5.1415 4.7737 1.077
## time_firstPFT:site22R 3.6203 2.8909 1.252
## time_firstPFT:site23R -1.6166 5.4078 -0.299
## time_firstPFT:site24R -3.5514 2.4866 -1.428
## time_firstPFT:site25R -5.2886 4.5258 -1.169
## time_firstPFT:site28R -9.4845 13.0734 -0.725
## time_firstPFT:site29R -4.0521 5.1991 -0.779
## time_firstPFT:site31R 1.0348 1.9636 0.527
## time_firstPFT:site32R -1.6739 3.5689 -0.469
## time_firstPFT:site33R -4.1788 3.8330 -1.090
## time_firstPFT:site34R 0.4870 2.3737 0.205
## time_firstPFT:site35R 8.1769 4.6046 1.776
## time_firstPFT:site36R 4.8588 2.9568 1.643
## time_firstPFT:site37R -1.8593 2.8652 -0.649
## time_firstPFT:site38R -2.3166 1.8971 -1.221
## time_firstPFT:site39R -30.2134 10.4426 -2.893
## time_firstPFT:site40R 1.6517 4.5778 0.361
## time_firstPFT:site41R 3.0328 6.6790 0.454
## time_firstPFT:site42R -3.1789 5.9422 -0.535##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.801
## Unadjusted ICC: 0.536report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SS_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.33. The model's
## intercept, corresponding to time_firstPFT = 0, is at 41.71 (95% CI [38.73,
## 44.69], t(2068) = 27.45, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.71, 95% CI [-6.10, -3.33], t(2068) = -6.67, p < .001; Std. beta = -0.52, 95%
## CI [-0.64, -0.40])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.88, 95% CI [-17.63, 3.87], t(2068) = -1.26, p = 0.210; Std. beta =
## -0.05, 95% CI [-0.19, 0.10])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-22.37, 50.74], t(2068) = 0.76, p = 0.447; Std. beta = -3.16,
## 95% CI [-6.97, 0.66])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.53, 95% CI [6.09, 44.97], t(2068) = 2.58, p = 0.010; Std. beta = 1.60, 95%
## CI [0.33, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-23.16, 13.30], t(2068) = -0.53, p = 0.596; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.94, 95% CI [-28.23, 2.34], t(2068) = -1.66, p = 0.097; Std. beta = -1.25,
## 95% CI [-2.73, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-14.14, 23.90], t(2068) = 0.50, p = 0.615; Std. beta = 0.65,
## 95% CI [-0.71, 2.01])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-1.30, 13.20], t(2068) = 1.61, p = 0.107; Std. beta = 0.11, 95%
## CI [-0.36, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-25.22, 12.14], t(2068) = -0.69, p = 0.492; Std. beta = -0.42,
## 95% CI [-1.69, 0.86])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.61, 95% CI [15.67, 25.56], t(2068) = 8.18, p < .001; Std. beta = 1.28, 95%
## CI [0.95, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-1.34, 18.22], t(2068) = 1.69, p = 0.091; Std. beta = 0.42, 95%
## CI [-0.23, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-5.33, 3.25], t(2068) = -0.48, p = 0.633; Std. beta = 0.03,
## 95% CI [-0.26, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.99, 95% CI [-19.14, 1.16], t(2068) = -1.74, p = 0.083; Std. beta = -0.40,
## 95% CI [-1.26, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-2.74, 7.03], t(2068) = 0.86, p = 0.389; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-9.62, 3.64], t(2068) = -0.88, p = 0.376; Std. beta = -0.10,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-7.84, 29.89], t(2068) = 1.15, p = 0.252; Std. beta = -0.66,
## 95% CI [-2.28, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.44, 95% CI [-23.27, 6.39], t(2068) = -1.12, p = 0.265; Std. beta = -0.17,
## 95% CI [-1.14, 0.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-27.49, 33.42], t(2068) = 0.19, p = 0.849; Std. beta = 0.20,
## 95% CI [-1.87, 2.27])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-10.89, 11.75], t(2068) = 0.07, p = 0.940; Std. beta = 0.50,
## 95% CI [-0.29, 1.29])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-27.70, 9.11], t(2068) = -0.99, p = 0.322; Std. beta = -0.50,
## 95% CI [-1.76, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-24.05, 4.67], t(2068) = -1.32, p = 0.186; Std. beta = -0.73,
## 95% CI [-1.68, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-34.36, 24.58], t(2068) = -0.33, p = 0.745; Std. beta = -1.54,
## 95% CI [-4.95, 1.88])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.97, 95% CI [-49.79, 3.85], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.82])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.66, 95% CI [-18.40, 5.08], t(2068) = -1.11, p = 0.266; Std. beta = -0.63,
## 95% CI [-1.44, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.31, 95% CI [32.47, 86.14], t(2068) = 4.33, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-21.64, 16.84], t(2068) = -0.24, p = 0.806; Std. beta = -1.37,
## 95% CI [-3.89, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.11, 95% CI [-17.13, 6.91], t(2068) = -0.83, p = 0.404; Std. beta = -0.13,
## 95% CI [-1.16, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-13.99, 7.93], t(2068) = -0.54, p = 0.588; Std. beta = -0.12,
## 95% CI [-0.93, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.14, 95% CI [-37.15, 12.88], t(2068) = -0.95, p = 0.342; Std. beta =
## -0.30, 95% CI [-1.88, 1.28])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.53, 95% CI [-18.10, -0.95], t(2068) = -2.18, p = 0.029; Std. beta = -0.28,
## 95% CI [-0.93, 0.38])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.37, 95% CI [-29.50, -5.24], t(2068) = -2.81, p = 0.005; Std. beta = -1.35,
## 95% CI [-2.51, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-7.68, 12.13], t(2068) = 0.44, p = 0.659; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.59, 95% CI [-14.46, 21.64], t(2068) = 0.39, p = 0.696; Std. beta = -0.30,
## 95% CI [-1.50, 0.91])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.06, 95% CI [-32.61, -1.50], t(2068) = -2.15, p = 0.032; Std. beta = -2.14,
## 95% CI [-4.70, 0.43])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-22.91, 29.99], t(2068) = 0.26, p = 0.793; Std. beta = -0.18,
## 95% CI [-1.80, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-10.81, 11.92], t(2068) = 0.10, p = 0.924; Std. beta = 0.14,
## 95% CI [-0.57, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.94, 95% CI [-7.15, 19.03], t(2068) = 0.89, p = 0.373; Std. beta = 0.23, 95%
## CI [-0.69, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-19.37, 7.38], t(2068) = -0.88, p = 0.379; Std. beta = -0.84,
## 95% CI [-1.84, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.14, 95% CI [-13.95, 5.67], t(2068) = -0.83, p = 0.408; Std. beta = -0.23,
## 95% CI [-0.90, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.67, 95% CI [-28.06, 2.71], t(2068) = -1.62, p = 0.106; Std. beta = -0.02,
## 95% CI [-1.11, 1.07])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.83, 95% CI [-7.87, 15.53], t(2068) = 0.64, p = 0.521; Std. beta = 0.76, 95%
## CI [-0.07, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.65, 95% CI [-10.13, 15.42], t(2068) = 0.41, p = 0.685; Std. beta = -0.01,
## 95% CI [-0.85, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-9.86, 7.53], t(2068) = -0.26, p = 0.793; Std. beta = -0.32,
## 95% CI [-0.89, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-19.99, 32.28], t(2068) = 0.46, p = 0.645; Std. beta = -2.69,
## 95% CI [-4.84, -0.53])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-15.09, 21.66], t(2068) = 0.35, p = 0.726; Std. beta = 0.39,
## 95% CI [-0.92, 1.71])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.17, 3.33], t(2068) = -1.53, p = 0.125; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.62, 95% CI [-16.20, 0.96], t(2068) = -1.74, p = 0.082; Std. beta = -0.84,
## 95% CI [-1.94, 0.25])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.25, 95% CI [-3.18, 7.69], t(2068) =
## 0.81, p = 0.416; Std. beta = 0.05, 95% CI [-0.08, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -40.10, 95% CI [-78.62, -1.57], t(2068) = -2.04, p = 0.041;
## Std. beta = -4.97, 95% CI [-9.74, -0.19])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-13.00, 10.32], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.29, 10.28], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.37, 11.28], t(2068) = -0.47, p = 0.639;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-6.83, 12.99], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.38, 95% CI [-0.85, 1.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.91, 95% CI [-5.68, -0.15], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-8.10, 8.62], t(2068) = 0.06, p = 0.952; Std.
## beta = 0.03, 95% CI [-1.00, 1.07])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-3.30, 0.88], t(2068) = -1.13, p = 0.257; Std.
## beta = -0.15, 95% CI [-0.41, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.52, 95% CI [-5.82, 2.78], t(2068) = -0.70, p = 0.487; Std.
## beta = -0.19, 95% CI [-0.72, 0.34])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-0.94, 2.86], t(2068) = 0.99, p = 0.320; Std.
## beta = 0.12, 95% CI [-0.12, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-5.24, 9.38], t(2068) = 0.55, p = 0.579; Std.
## beta = 0.26, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.55, 1.65], t(2068) = -0.42, p = 0.672; Std.
## beta = -0.06, 95% CI [-0.32, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.14, 4.19], t(2068) = 0.63, p = 0.526; Std.
## beta = 0.13, 95% CI [-0.27, 0.52])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.70, 95% CI [-29.71, 2.31], t(2068) = -1.68, p = 0.093;
## Std. beta = -1.70, 95% CI [-3.68, 0.29])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-2.79, 10.57], t(2068) = 1.14, p = 0.254; Std.
## beta = 0.48, 95% CI [-0.35, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-0.87, 10.07], t(2068) = 1.65, p = 0.099; Std.
## beta = 0.57, 95% CI [-0.11, 1.25])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-6.58, 9.19], t(2068) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-8.45, 7.02], t(2068) = -0.18, p = 0.857; Std.
## beta = -0.09, 95% CI [-1.05, 0.87])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.70, 95% CI [-58.17, 34.78], t(2068) = -0.49, p = 0.622;
## Std. beta = -1.45, 95% CI [-7.21, 4.31])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.29, 95% CI [-30.07, 25.48], t(2068) = -0.16, p = 0.871;
## Std. beta = -0.28, 95% CI [-3.73, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-6.97, 3.46], t(2068) = -0.66, p = 0.510; Std.
## beta = -0.22, 95% CI [-0.86, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.73, 95% CI [-37.23, 13.77], t(2068) = -0.90, p = 0.367;
## Std. beta = -1.45, 95% CI [-4.61, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-7.33, 11.62], t(2068) = 0.44, p = 0.658; Std.
## beta = 0.27, 95% CI [-0.91, 1.44])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-5.82, 7.52], t(2068) = 0.25, p = 0.802; Std.
## beta = 0.11, 95% CI [-0.72, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-4.22, 14.50], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.64, 95% CI [-0.52, 1.80])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.05, 9.29], t(2068) = 1.25, p = 0.211; Std.
## beta = 0.45, 95% CI [-0.25, 1.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std.
## beta = -0.20, 95% CI [-1.51, 1.11])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-8.43, 1.33], t(2068) = -1.43, p = 0.153; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.16, 3.59], t(2068) = -1.17, p = 0.243; Std.
## beta = -0.66, 95% CI [-1.75, 0.44])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.48, 95% CI [-35.12, 16.15], t(2068) = -0.73, p = 0.468;
## Std. beta = -1.17, 95% CI [-4.35, 2.00])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.05, 95% CI [-14.25, 6.14], t(2068) = -0.78, p = 0.436; Std.
## beta = -0.50, 95% CI [-1.76, 0.76])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.03, 95% CI [-2.82, 4.89], t(2068) = 0.53, p = 0.598; Std.
## beta = 0.13, 95% CI [-0.35, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-8.67, 5.33], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.21, 95% CI [-1.07, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-11.70, 3.34], t(2068) = -1.09, p = 0.276; Std.
## beta = -0.52, 95% CI [-1.45, 0.41])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-4.17, 5.14], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.06, 95% CI [-0.52, 0.64])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.18, 95% CI [-0.85, 17.21], t(2068) = 1.78, p = 0.076; Std.
## beta = 1.01, 95% CI [-0.11, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-0.94, 10.66], t(2068) = 1.64, p = 0.100; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.48, 3.76], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.23, 95% CI [-0.93, 0.47])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-6.04, 1.40], t(2068) = -1.22, p = 0.222; Std.
## beta = -0.29, 95% CI [-0.75, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.21, 95% CI [-50.69, -9.73], t(2068) = -2.89, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.28, -1.21])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-7.33, 10.63], t(2068) = 0.36, p = 0.718; Std.
## beta = 0.20, 95% CI [-0.91, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-10.07, 16.13], t(2068) = 0.45, p = 0.650; Std.
## beta = 0.38, 95% CI [-1.25, 2.00])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.18, 95% CI [-14.83, 8.47], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.84, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SS_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to SS_5yrPreCensor = 0, is at 41.71 (95% CI [38.73, 44.69],
## t(2068) = 27.45, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.71, 95% CI [-6.10, -3.33], t(2068) = -6.67, p < .001; Std. beta = -0.52, 95%
## CI [-0.64, -0.40])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.88, 95% CI [-17.63, 3.87], t(2068) = -1.26, p = 0.210; Std. beta =
## -0.05, 95% CI [-0.19, 0.10])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-22.37, 50.74], t(2068) = 0.76, p = 0.447; Std. beta = -3.16,
## 95% CI [-6.97, 0.66])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.53, 95% CI [6.09, 44.97], t(2068) = 2.58, p = 0.010; Std. beta = 1.60, 95%
## CI [0.33, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-23.16, 13.30], t(2068) = -0.53, p = 0.596; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.94, 95% CI [-28.23, 2.34], t(2068) = -1.66, p = 0.097; Std. beta = -1.25,
## 95% CI [-2.73, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-14.14, 23.90], t(2068) = 0.50, p = 0.615; Std. beta = 0.65,
## 95% CI [-0.71, 2.01])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-1.30, 13.20], t(2068) = 1.61, p = 0.107; Std. beta = 0.11, 95%
## CI [-0.36, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-25.22, 12.14], t(2068) = -0.69, p = 0.492; Std. beta = -0.42,
## 95% CI [-1.69, 0.86])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.61, 95% CI [15.67, 25.56], t(2068) = 8.18, p < .001; Std. beta = 1.28, 95%
## CI [0.95, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-1.34, 18.22], t(2068) = 1.69, p = 0.091; Std. beta = 0.42, 95%
## CI [-0.23, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-5.33, 3.25], t(2068) = -0.48, p = 0.633; Std. beta = 0.03,
## 95% CI [-0.26, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.99, 95% CI [-19.14, 1.16], t(2068) = -1.74, p = 0.083; Std. beta = -0.40,
## 95% CI [-1.26, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-2.74, 7.03], t(2068) = 0.86, p = 0.389; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-9.62, 3.64], t(2068) = -0.88, p = 0.376; Std. beta = -0.10,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-7.84, 29.89], t(2068) = 1.15, p = 0.252; Std. beta = -0.66,
## 95% CI [-2.28, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.44, 95% CI [-23.27, 6.39], t(2068) = -1.12, p = 0.265; Std. beta = -0.17,
## 95% CI [-1.14, 0.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-27.49, 33.42], t(2068) = 0.19, p = 0.849; Std. beta = 0.20,
## 95% CI [-1.87, 2.27])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-10.89, 11.75], t(2068) = 0.07, p = 0.940; Std. beta = 0.50,
## 95% CI [-0.29, 1.29])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-27.70, 9.11], t(2068) = -0.99, p = 0.322; Std. beta = -0.50,
## 95% CI [-1.76, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-24.05, 4.67], t(2068) = -1.32, p = 0.186; Std. beta = -0.73,
## 95% CI [-1.68, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-34.36, 24.58], t(2068) = -0.33, p = 0.745; Std. beta = -1.54,
## 95% CI [-4.95, 1.88])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.97, 95% CI [-49.79, 3.85], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.82])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.66, 95% CI [-18.40, 5.08], t(2068) = -1.11, p = 0.266; Std. beta = -0.63,
## 95% CI [-1.44, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.31, 95% CI [32.47, 86.14], t(2068) = 4.33, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-21.64, 16.84], t(2068) = -0.24, p = 0.806; Std. beta = -1.37,
## 95% CI [-3.89, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.11, 95% CI [-17.13, 6.91], t(2068) = -0.83, p = 0.404; Std. beta = -0.13,
## 95% CI [-1.16, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-13.99, 7.93], t(2068) = -0.54, p = 0.588; Std. beta = -0.12,
## 95% CI [-0.93, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.14, 95% CI [-37.15, 12.88], t(2068) = -0.95, p = 0.342; Std. beta =
## -0.30, 95% CI [-1.88, 1.28])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.53, 95% CI [-18.10, -0.95], t(2068) = -2.18, p = 0.029; Std. beta = -0.28,
## 95% CI [-0.93, 0.38])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.37, 95% CI [-29.50, -5.24], t(2068) = -2.81, p = 0.005; Std. beta = -1.35,
## 95% CI [-2.51, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-7.68, 12.13], t(2068) = 0.44, p = 0.659; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.59, 95% CI [-14.46, 21.64], t(2068) = 0.39, p = 0.696; Std. beta = -0.30,
## 95% CI [-1.50, 0.91])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.06, 95% CI [-32.61, -1.50], t(2068) = -2.15, p = 0.032; Std. beta = -2.14,
## 95% CI [-4.70, 0.43])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-22.91, 29.99], t(2068) = 0.26, p = 0.793; Std. beta = -0.18,
## 95% CI [-1.80, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-10.81, 11.92], t(2068) = 0.10, p = 0.924; Std. beta = 0.14,
## 95% CI [-0.57, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.94, 95% CI [-7.15, 19.03], t(2068) = 0.89, p = 0.373; Std. beta = 0.23, 95%
## CI [-0.69, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-19.37, 7.38], t(2068) = -0.88, p = 0.379; Std. beta = -0.84,
## 95% CI [-1.84, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.14, 95% CI [-13.95, 5.67], t(2068) = -0.83, p = 0.408; Std. beta = -0.23,
## 95% CI [-0.90, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.67, 95% CI [-28.06, 2.71], t(2068) = -1.62, p = 0.106; Std. beta = -0.02,
## 95% CI [-1.11, 1.07])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.83, 95% CI [-7.87, 15.53], t(2068) = 0.64, p = 0.521; Std. beta = 0.76, 95%
## CI [-0.07, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.65, 95% CI [-10.13, 15.42], t(2068) = 0.41, p = 0.685; Std. beta = -0.01,
## 95% CI [-0.85, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-9.86, 7.53], t(2068) = -0.26, p = 0.793; Std. beta = -0.32,
## 95% CI [-0.89, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-19.99, 32.28], t(2068) = 0.46, p = 0.645; Std. beta = -2.69,
## 95% CI [-4.84, -0.53])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-15.09, 21.66], t(2068) = 0.35, p = 0.726; Std. beta = 0.39,
## 95% CI [-0.92, 1.71])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.17, 3.33], t(2068) = -1.53, p = 0.125; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.62, 95% CI [-16.20, 0.96], t(2068) = -1.74, p = 0.082; Std. beta = -0.84,
## 95% CI [-1.94, 0.25])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.25, 95% CI [-3.18, 7.69], t(2068) =
## 0.81, p = 0.416; Std. beta = 0.05, 95% CI [-0.08, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -40.10, 95% CI [-78.62, -1.57], t(2068) = -2.04, p = 0.041;
## Std. beta = -4.97, 95% CI [-9.74, -0.19])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-13.00, 10.32], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.29, 10.28], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.37, 11.28], t(2068) = -0.47, p = 0.639;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-6.83, 12.99], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.38, 95% CI [-0.85, 1.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.91, 95% CI [-5.68, -0.15], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-8.10, 8.62], t(2068) = 0.06, p = 0.952; Std.
## beta = 0.03, 95% CI [-1.00, 1.07])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-3.30, 0.88], t(2068) = -1.13, p = 0.257; Std.
## beta = -0.15, 95% CI [-0.41, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.52, 95% CI [-5.82, 2.78], t(2068) = -0.70, p = 0.487; Std.
## beta = -0.19, 95% CI [-0.72, 0.34])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-0.94, 2.86], t(2068) = 0.99, p = 0.320; Std.
## beta = 0.12, 95% CI [-0.12, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-5.24, 9.38], t(2068) = 0.55, p = 0.579; Std.
## beta = 0.26, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.55, 1.65], t(2068) = -0.42, p = 0.672; Std.
## beta = -0.06, 95% CI [-0.32, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.14, 4.19], t(2068) = 0.63, p = 0.526; Std.
## beta = 0.13, 95% CI [-0.27, 0.52])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.70, 95% CI [-29.71, 2.31], t(2068) = -1.68, p = 0.093;
## Std. beta = -1.70, 95% CI [-3.68, 0.29])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-2.79, 10.57], t(2068) = 1.14, p = 0.254; Std.
## beta = 0.48, 95% CI [-0.35, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-0.87, 10.07], t(2068) = 1.65, p = 0.099; Std.
## beta = 0.57, 95% CI [-0.11, 1.25])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-6.58, 9.19], t(2068) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-8.45, 7.02], t(2068) = -0.18, p = 0.857; Std.
## beta = -0.09, 95% CI [-1.05, 0.87])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.70, 95% CI [-58.17, 34.78], t(2068) = -0.49, p = 0.622;
## Std. beta = -1.45, 95% CI [-7.21, 4.31])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.29, 95% CI [-30.07, 25.48], t(2068) = -0.16, p = 0.871;
## Std. beta = -0.28, 95% CI [-3.73, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-6.97, 3.46], t(2068) = -0.66, p = 0.510; Std.
## beta = -0.22, 95% CI [-0.86, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.73, 95% CI [-37.23, 13.77], t(2068) = -0.90, p = 0.367;
## Std. beta = -1.45, 95% CI [-4.61, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-7.33, 11.62], t(2068) = 0.44, p = 0.658; Std.
## beta = 0.27, 95% CI [-0.91, 1.44])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-5.82, 7.52], t(2068) = 0.25, p = 0.802; Std.
## beta = 0.11, 95% CI [-0.72, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-4.22, 14.50], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.64, 95% CI [-0.52, 1.80])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.05, 9.29], t(2068) = 1.25, p = 0.211; Std.
## beta = 0.45, 95% CI [-0.25, 1.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std.
## beta = -0.20, 95% CI [-1.51, 1.11])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-8.43, 1.33], t(2068) = -1.43, p = 0.153; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.16, 3.59], t(2068) = -1.17, p = 0.243; Std.
## beta = -0.66, 95% CI [-1.75, 0.44])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.48, 95% CI [-35.12, 16.15], t(2068) = -0.73, p = 0.468;
## Std. beta = -1.17, 95% CI [-4.35, 2.00])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.05, 95% CI [-14.25, 6.14], t(2068) = -0.78, p = 0.436; Std.
## beta = -0.50, 95% CI [-1.76, 0.76])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.03, 95% CI [-2.82, 4.89], t(2068) = 0.53, p = 0.598; Std.
## beta = 0.13, 95% CI [-0.35, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-8.67, 5.33], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.21, 95% CI [-1.07, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-11.70, 3.34], t(2068) = -1.09, p = 0.276; Std.
## beta = -0.52, 95% CI [-1.45, 0.41])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-4.17, 5.14], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.06, 95% CI [-0.52, 0.64])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.18, 95% CI [-0.85, 17.21], t(2068) = 1.78, p = 0.076; Std.
## beta = 1.01, 95% CI [-0.11, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-0.94, 10.66], t(2068) = 1.64, p = 0.100; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.48, 3.76], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.23, 95% CI [-0.93, 0.47])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-6.04, 1.40], t(2068) = -1.22, p = 0.222; Std.
## beta = -0.29, 95% CI [-0.75, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.21, 95% CI [-50.69, -9.73], t(2068) = -2.89, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.28, -1.21])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-7.33, 10.63], t(2068) = 0.36, p = 0.718; Std.
## beta = 0.20, 95% CI [-0.91, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-10.07, 16.13], t(2068) = 0.45, p = 0.650; Std.
## beta = 0.38, 95% CI [-1.25, 2.00])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.18, 95% CI [-14.83, 8.47], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.84, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.33. The model's intercept, corresponding to site =
## Simmons, is at 41.71 (95% CI [38.73, 44.69], t(2068) = 27.45, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.71, 95% CI [-6.10, -3.33], t(2068) = -6.67, p < .001; Std. beta = -0.52, 95%
## CI [-0.64, -0.40])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.88, 95% CI [-17.63, 3.87], t(2068) = -1.26, p = 0.210; Std. beta =
## -0.05, 95% CI [-0.19, 0.10])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-22.37, 50.74], t(2068) = 0.76, p = 0.447; Std. beta = -3.16,
## 95% CI [-6.97, 0.66])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.53, 95% CI [6.09, 44.97], t(2068) = 2.58, p = 0.010; Std. beta = 1.60, 95%
## CI [0.33, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-23.16, 13.30], t(2068) = -0.53, p = 0.596; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.94, 95% CI [-28.23, 2.34], t(2068) = -1.66, p = 0.097; Std. beta = -1.25,
## 95% CI [-2.73, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-14.14, 23.90], t(2068) = 0.50, p = 0.615; Std. beta = 0.65,
## 95% CI [-0.71, 2.01])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-1.30, 13.20], t(2068) = 1.61, p = 0.107; Std. beta = 0.11, 95%
## CI [-0.36, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-25.22, 12.14], t(2068) = -0.69, p = 0.492; Std. beta = -0.42,
## 95% CI [-1.69, 0.86])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.61, 95% CI [15.67, 25.56], t(2068) = 8.18, p < .001; Std. beta = 1.28, 95%
## CI [0.95, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-1.34, 18.22], t(2068) = 1.69, p = 0.091; Std. beta = 0.42, 95%
## CI [-0.23, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-5.33, 3.25], t(2068) = -0.48, p = 0.633; Std. beta = 0.03,
## 95% CI [-0.26, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.99, 95% CI [-19.14, 1.16], t(2068) = -1.74, p = 0.083; Std. beta = -0.40,
## 95% CI [-1.26, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-2.74, 7.03], t(2068) = 0.86, p = 0.389; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-9.62, 3.64], t(2068) = -0.88, p = 0.376; Std. beta = -0.10,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-7.84, 29.89], t(2068) = 1.15, p = 0.252; Std. beta = -0.66,
## 95% CI [-2.28, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.44, 95% CI [-23.27, 6.39], t(2068) = -1.12, p = 0.265; Std. beta = -0.17,
## 95% CI [-1.14, 0.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-27.49, 33.42], t(2068) = 0.19, p = 0.849; Std. beta = 0.20,
## 95% CI [-1.87, 2.27])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-10.89, 11.75], t(2068) = 0.07, p = 0.940; Std. beta = 0.50,
## 95% CI [-0.29, 1.29])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-27.70, 9.11], t(2068) = -0.99, p = 0.322; Std. beta = -0.50,
## 95% CI [-1.76, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-24.05, 4.67], t(2068) = -1.32, p = 0.186; Std. beta = -0.73,
## 95% CI [-1.68, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-34.36, 24.58], t(2068) = -0.33, p = 0.745; Std. beta = -1.54,
## 95% CI [-4.95, 1.88])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.97, 95% CI [-49.79, 3.85], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.82])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.66, 95% CI [-18.40, 5.08], t(2068) = -1.11, p = 0.266; Std. beta = -0.63,
## 95% CI [-1.44, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.31, 95% CI [32.47, 86.14], t(2068) = 4.33, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-21.64, 16.84], t(2068) = -0.24, p = 0.806; Std. beta = -1.37,
## 95% CI [-3.89, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.11, 95% CI [-17.13, 6.91], t(2068) = -0.83, p = 0.404; Std. beta = -0.13,
## 95% CI [-1.16, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-13.99, 7.93], t(2068) = -0.54, p = 0.588; Std. beta = -0.12,
## 95% CI [-0.93, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.14, 95% CI [-37.15, 12.88], t(2068) = -0.95, p = 0.342; Std. beta =
## -0.30, 95% CI [-1.88, 1.28])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.53, 95% CI [-18.10, -0.95], t(2068) = -2.18, p = 0.029; Std. beta = -0.28,
## 95% CI [-0.93, 0.38])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.37, 95% CI [-29.50, -5.24], t(2068) = -2.81, p = 0.005; Std. beta = -1.35,
## 95% CI [-2.51, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-7.68, 12.13], t(2068) = 0.44, p = 0.659; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.59, 95% CI [-14.46, 21.64], t(2068) = 0.39, p = 0.696; Std. beta = -0.30,
## 95% CI [-1.50, 0.91])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.06, 95% CI [-32.61, -1.50], t(2068) = -2.15, p = 0.032; Std. beta = -2.14,
## 95% CI [-4.70, 0.43])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-22.91, 29.99], t(2068) = 0.26, p = 0.793; Std. beta = -0.18,
## 95% CI [-1.80, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-10.81, 11.92], t(2068) = 0.10, p = 0.924; Std. beta = 0.14,
## 95% CI [-0.57, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.94, 95% CI [-7.15, 19.03], t(2068) = 0.89, p = 0.373; Std. beta = 0.23, 95%
## CI [-0.69, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-19.37, 7.38], t(2068) = -0.88, p = 0.379; Std. beta = -0.84,
## 95% CI [-1.84, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.14, 95% CI [-13.95, 5.67], t(2068) = -0.83, p = 0.408; Std. beta = -0.23,
## 95% CI [-0.90, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.67, 95% CI [-28.06, 2.71], t(2068) = -1.62, p = 0.106; Std. beta = -0.02,
## 95% CI [-1.11, 1.07])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.83, 95% CI [-7.87, 15.53], t(2068) = 0.64, p = 0.521; Std. beta = 0.76, 95%
## CI [-0.07, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.65, 95% CI [-10.13, 15.42], t(2068) = 0.41, p = 0.685; Std. beta = -0.01,
## 95% CI [-0.85, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-9.86, 7.53], t(2068) = -0.26, p = 0.793; Std. beta = -0.32,
## 95% CI [-0.89, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-19.99, 32.28], t(2068) = 0.46, p = 0.645; Std. beta = -2.69,
## 95% CI [-4.84, -0.53])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-15.09, 21.66], t(2068) = 0.35, p = 0.726; Std. beta = 0.39,
## 95% CI [-0.92, 1.71])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.17, 3.33], t(2068) = -1.53, p = 0.125; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.62, 95% CI [-16.20, 0.96], t(2068) = -1.74, p = 0.082; Std. beta = -0.84,
## 95% CI [-1.94, 0.25])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.25, 95% CI [-3.18, 7.69], t(2068) =
## 0.81, p = 0.416; Std. beta = 0.05, 95% CI [-0.08, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -40.10, 95% CI [-78.62, -1.57], t(2068) = -2.04, p = 0.041;
## Std. beta = -4.97, 95% CI [-9.74, -0.19])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-13.00, 10.32], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.29, 10.28], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.37, 11.28], t(2068) = -0.47, p = 0.639;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-6.83, 12.99], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.38, 95% CI [-0.85, 1.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.91, 95% CI [-5.68, -0.15], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-8.10, 8.62], t(2068) = 0.06, p = 0.952; Std.
## beta = 0.03, 95% CI [-1.00, 1.07])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-3.30, 0.88], t(2068) = -1.13, p = 0.257; Std.
## beta = -0.15, 95% CI [-0.41, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.52, 95% CI [-5.82, 2.78], t(2068) = -0.70, p = 0.487; Std.
## beta = -0.19, 95% CI [-0.72, 0.34])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-0.94, 2.86], t(2068) = 0.99, p = 0.320; Std.
## beta = 0.12, 95% CI [-0.12, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-5.24, 9.38], t(2068) = 0.55, p = 0.579; Std.
## beta = 0.26, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.55, 1.65], t(2068) = -0.42, p = 0.672; Std.
## beta = -0.06, 95% CI [-0.32, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.14, 4.19], t(2068) = 0.63, p = 0.526; Std.
## beta = 0.13, 95% CI [-0.27, 0.52])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.70, 95% CI [-29.71, 2.31], t(2068) = -1.68, p = 0.093;
## Std. beta = -1.70, 95% CI [-3.68, 0.29])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-2.79, 10.57], t(2068) = 1.14, p = 0.254; Std.
## beta = 0.48, 95% CI [-0.35, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-0.87, 10.07], t(2068) = 1.65, p = 0.099; Std.
## beta = 0.57, 95% CI [-0.11, 1.25])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-6.58, 9.19], t(2068) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-8.45, 7.02], t(2068) = -0.18, p = 0.857; Std.
## beta = -0.09, 95% CI [-1.05, 0.87])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.70, 95% CI [-58.17, 34.78], t(2068) = -0.49, p = 0.622;
## Std. beta = -1.45, 95% CI [-7.21, 4.31])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.29, 95% CI [-30.07, 25.48], t(2068) = -0.16, p = 0.871;
## Std. beta = -0.28, 95% CI [-3.73, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-6.97, 3.46], t(2068) = -0.66, p = 0.510; Std.
## beta = -0.22, 95% CI [-0.86, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.73, 95% CI [-37.23, 13.77], t(2068) = -0.90, p = 0.367;
## Std. beta = -1.45, 95% CI [-4.61, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-7.33, 11.62], t(2068) = 0.44, p = 0.658; Std.
## beta = 0.27, 95% CI [-0.91, 1.44])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-5.82, 7.52], t(2068) = 0.25, p = 0.802; Std.
## beta = 0.11, 95% CI [-0.72, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-4.22, 14.50], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.64, 95% CI [-0.52, 1.80])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.05, 9.29], t(2068) = 1.25, p = 0.211; Std.
## beta = 0.45, 95% CI [-0.25, 1.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std.
## beta = -0.20, 95% CI [-1.51, 1.11])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-8.43, 1.33], t(2068) = -1.43, p = 0.153; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.16, 3.59], t(2068) = -1.17, p = 0.243; Std.
## beta = -0.66, 95% CI [-1.75, 0.44])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.48, 95% CI [-35.12, 16.15], t(2068) = -0.73, p = 0.468;
## Std. beta = -1.17, 95% CI [-4.35, 2.00])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.05, 95% CI [-14.25, 6.14], t(2068) = -0.78, p = 0.436; Std.
## beta = -0.50, 95% CI [-1.76, 0.76])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.03, 95% CI [-2.82, 4.89], t(2068) = 0.53, p = 0.598; Std.
## beta = 0.13, 95% CI [-0.35, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-8.67, 5.33], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.21, 95% CI [-1.07, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-11.70, 3.34], t(2068) = -1.09, p = 0.276; Std.
## beta = -0.52, 95% CI [-1.45, 0.41])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-4.17, 5.14], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.06, 95% CI [-0.52, 0.64])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.18, 95% CI [-0.85, 17.21], t(2068) = 1.78, p = 0.076; Std.
## beta = 1.01, 95% CI [-0.11, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-0.94, 10.66], t(2068) = 1.64, p = 0.100; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.48, 3.76], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.23, 95% CI [-0.93, 0.47])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-6.04, 1.40], t(2068) = -1.22, p = 0.222; Std.
## beta = -0.29, 95% CI [-0.75, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.21, 95% CI [-50.69, -9.73], t(2068) = -2.89, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.28, -1.21])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-7.33, 10.63], t(2068) = 0.36, p = 0.718; Std.
## beta = 0.20, 95% CI [-0.91, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-10.07, 16.13], t(2068) = 0.45, p = 0.650; Std.
## beta = 0.38, 95% CI [-1.25, 2.00])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.18, 95% CI [-14.83, 8.47], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.84, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to cohort = CARE-PF, is at 41.71 (95% CI [38.73, 44.69], t(2068)
## = 27.45, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -4.71, 95% CI [-6.10, -3.33], t(2068) = -6.67, p < .001; Std. beta = -0.52, 95%
## CI [-0.64, -0.40])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.88, 95% CI [-17.63, 3.87], t(2068) = -1.26, p = 0.210; Std. beta =
## -0.05, 95% CI [-0.19, 0.10])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 14.18, 95% CI [-22.37, 50.74], t(2068) = 0.76, p = 0.447; Std. beta = -3.16,
## 95% CI [-6.97, 0.66])
## - The effect of site [03R] is statistically significant and positive (beta =
## 25.53, 95% CI [6.09, 44.97], t(2068) = 2.58, p = 0.010; Std. beta = 1.60, 95%
## CI [0.33, 2.86])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.93, 95% CI [-23.16, 13.30], t(2068) = -0.53, p = 0.596; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.94, 95% CI [-28.23, 2.34], t(2068) = -1.66, p = 0.097; Std. beta = -1.25,
## 95% CI [-2.73, 0.24])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 4.88, 95% CI [-14.14, 23.90], t(2068) = 0.50, p = 0.615; Std. beta = 0.65,
## 95% CI [-0.71, 2.01])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.95, 95% CI [-1.30, 13.20], t(2068) = 1.61, p = 0.107; Std. beta = 0.11, 95%
## CI [-0.36, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -6.54, 95% CI [-25.22, 12.14], t(2068) = -0.69, p = 0.492; Std. beta = -0.42,
## 95% CI [-1.69, 0.86])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.61, 95% CI [15.67, 25.56], t(2068) = 8.18, p < .001; Std. beta = 1.28, 95%
## CI [0.95, 1.61])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.44, 95% CI [-1.34, 18.22], t(2068) = 1.69, p = 0.091; Std. beta = 0.42, 95%
## CI [-0.23, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.04, 95% CI [-5.33, 3.25], t(2068) = -0.48, p = 0.633; Std. beta = 0.03,
## 95% CI [-0.26, 0.32])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -8.99, 95% CI [-19.14, 1.16], t(2068) = -1.74, p = 0.083; Std. beta = -0.40,
## 95% CI [-1.26, 0.46])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.14, 95% CI [-2.74, 7.03], t(2068) = 0.86, p = 0.389; Std. beta = 0.10, 95%
## CI [-0.22, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -2.99, 95% CI [-9.62, 3.64], t(2068) = -0.88, p = 0.376; Std. beta = -0.10,
## 95% CI [-0.53, 0.34])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 11.02, 95% CI [-7.84, 29.89], t(2068) = 1.15, p = 0.252; Std. beta = -0.66,
## 95% CI [-2.28, 0.96])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -8.44, 95% CI [-23.27, 6.39], t(2068) = -1.12, p = 0.265; Std. beta = -0.17,
## 95% CI [-1.14, 0.79])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.96, 95% CI [-27.49, 33.42], t(2068) = 0.19, p = 0.849; Std. beta = 0.20,
## 95% CI [-1.87, 2.27])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 0.43, 95% CI [-10.89, 11.75], t(2068) = 0.07, p = 0.940; Std. beta = 0.50,
## 95% CI [-0.29, 1.29])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -9.30, 95% CI [-27.70, 9.11], t(2068) = -0.99, p = 0.322; Std. beta = -0.50,
## 95% CI [-1.76, 0.77])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -9.69, 95% CI [-24.05, 4.67], t(2068) = -1.32, p = 0.186; Std. beta = -0.73,
## 95% CI [-1.68, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-34.36, 24.58], t(2068) = -0.33, p = 0.745; Std. beta = -1.54,
## 95% CI [-4.95, 1.88])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.97, 95% CI [-49.79, 3.85], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.82])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.66, 95% CI [-18.40, 5.08], t(2068) = -1.11, p = 0.266; Std. beta = -0.63,
## 95% CI [-1.44, 0.18])
## - The effect of site [17R] is statistically significant and positive (beta =
## 59.31, 95% CI [32.47, 86.14], t(2068) = 4.33, p < .001; Std. beta = 4.03, 95%
## CI [2.21, 5.86])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.40, 95% CI [-21.64, 16.84], t(2068) = -0.24, p = 0.806; Std. beta = -1.37,
## 95% CI [-3.89, 1.15])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -5.11, 95% CI [-17.13, 6.91], t(2068) = -0.83, p = 0.404; Std. beta = -0.13,
## 95% CI [-1.16, 0.91])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.03, 95% CI [-13.99, 7.93], t(2068) = -0.54, p = 0.588; Std. beta = -0.12,
## 95% CI [-0.93, 0.69])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.14, 95% CI [-37.15, 12.88], t(2068) = -0.95, p = 0.342; Std. beta =
## -0.30, 95% CI [-1.88, 1.28])
## - The effect of site [22R] is statistically significant and negative (beta =
## -9.53, 95% CI [-18.10, -0.95], t(2068) = -2.18, p = 0.029; Std. beta = -0.28,
## 95% CI [-0.93, 0.38])
## - The effect of site [23R] is statistically significant and negative (beta =
## -17.37, 95% CI [-29.50, -5.24], t(2068) = -2.81, p = 0.005; Std. beta = -1.35,
## 95% CI [-2.51, -0.19])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.23, 95% CI [-7.68, 12.13], t(2068) = 0.44, p = 0.659; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 3.59, 95% CI [-14.46, 21.64], t(2068) = 0.39, p = 0.696; Std. beta = -0.30,
## 95% CI [-1.50, 0.91])
## - The effect of site [28R] is statistically significant and negative (beta =
## -17.06, 95% CI [-32.61, -1.50], t(2068) = -2.15, p = 0.032; Std. beta = -2.14,
## 95% CI [-4.70, 0.43])
## - The effect of site [29R] is statistically non-significant and positive (beta
## = 3.54, 95% CI [-22.91, 29.99], t(2068) = 0.26, p = 0.793; Std. beta = -0.18,
## 95% CI [-1.80, 1.45])
## - The effect of site [31R] is statistically non-significant and positive (beta
## = 0.55, 95% CI [-10.81, 11.92], t(2068) = 0.10, p = 0.924; Std. beta = 0.14,
## 95% CI [-0.57, 0.86])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 5.94, 95% CI [-7.15, 19.03], t(2068) = 0.89, p = 0.373; Std. beta = 0.23, 95%
## CI [-0.69, 1.15])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.00, 95% CI [-19.37, 7.38], t(2068) = -0.88, p = 0.379; Std. beta = -0.84,
## 95% CI [-1.84, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.14, 95% CI [-13.95, 5.67], t(2068) = -0.83, p = 0.408; Std. beta = -0.23,
## 95% CI [-0.90, 0.43])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -12.67, 95% CI [-28.06, 2.71], t(2068) = -1.62, p = 0.106; Std. beta = -0.02,
## 95% CI [-1.11, 1.07])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.83, 95% CI [-7.87, 15.53], t(2068) = 0.64, p = 0.521; Std. beta = 0.76, 95%
## CI [-0.07, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 2.65, 95% CI [-10.13, 15.42], t(2068) = 0.41, p = 0.685; Std. beta = -0.01,
## 95% CI [-0.85, 0.83])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-9.86, 7.53], t(2068) = -0.26, p = 0.793; Std. beta = -0.32,
## 95% CI [-0.89, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 6.15, 95% CI [-19.99, 32.28], t(2068) = 0.46, p = 0.645; Std. beta = -2.69,
## 95% CI [-4.84, -0.53])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.29, 95% CI [-15.09, 21.66], t(2068) = 0.35, p = 0.726; Std. beta = 0.39,
## 95% CI [-0.92, 1.71])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -11.92, 95% CI [-27.17, 3.33], t(2068) = -1.53, p = 0.125; Std. beta = -0.50,
## 95% CI [-1.86, 0.87])
## - The effect of site [42R] is statistically non-significant and negative (beta
## = -7.62, 95% CI [-16.20, 0.96], t(2068) = -1.74, p = 0.082; Std. beta = -0.84,
## 95% CI [-1.94, 0.25])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.25, 95% CI [-3.18, 7.69], t(2068) =
## 0.81, p = 0.416; Std. beta = 0.05, 95% CI [-0.08, 0.18])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -40.10, 95% CI [-78.62, -1.57], t(2068) = -2.04, p = 0.041;
## Std. beta = -4.97, 95% CI [-9.74, -0.19])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.34, 95% CI [-13.00, 10.32], t(2068) = -0.23, p = 0.821;
## Std. beta = -0.17, 95% CI [-1.61, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.29, 10.28], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-18.37, 11.28], t(2068) = -0.47, p = 0.639;
## Std. beta = -0.44, 95% CI [-2.28, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 3.08, 95% CI [-6.83, 12.99], t(2068) = 0.61, p = 0.542; Std.
## beta = 0.38, 95% CI [-0.85, 1.61])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.91, 95% CI [-5.68, -0.15], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.26, 95% CI [-8.10, 8.62], t(2068) = 0.06, p = 0.952; Std.
## beta = 0.03, 95% CI [-1.00, 1.07])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -1.21, 95% CI [-3.30, 0.88], t(2068) = -1.13, p = 0.257; Std.
## beta = -0.15, 95% CI [-0.41, 0.11])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.52, 95% CI [-5.82, 2.78], t(2068) = -0.70, p = 0.487; Std.
## beta = -0.19, 95% CI [-0.72, 0.34])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 0.96, 95% CI [-0.94, 2.86], t(2068) = 0.99, p = 0.320; Std.
## beta = 0.12, 95% CI [-0.12, 0.35])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.07, 95% CI [-5.24, 9.38], t(2068) = 0.55, p = 0.579; Std.
## beta = 0.26, 95% CI [-0.65, 1.16])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.45, 95% CI [-2.55, 1.65], t(2068) = -0.42, p = 0.672; Std.
## beta = -0.06, 95% CI [-0.32, 0.20])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.02, 95% CI [-2.14, 4.19], t(2068) = 0.63, p = 0.526; Std.
## beta = 0.13, 95% CI [-0.27, 0.52])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.70, 95% CI [-29.71, 2.31], t(2068) = -1.68, p = 0.093;
## Std. beta = -1.70, 95% CI [-3.68, 0.29])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.89, 95% CI [-2.79, 10.57], t(2068) = 1.14, p = 0.254; Std.
## beta = 0.48, 95% CI [-0.35, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-0.87, 10.07], t(2068) = 1.65, p = 0.099; Std.
## beta = 0.57, 95% CI [-0.11, 1.25])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.31, 95% CI [-6.58, 9.19], t(2068) = 0.32, p = 0.745; Std.
## beta = 0.16, 95% CI [-0.81, 1.14])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.71, 95% CI [-8.45, 7.02], t(2068) = -0.18, p = 0.857; Std.
## beta = -0.09, 95% CI [-1.05, 0.87])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -11.70, 95% CI [-58.17, 34.78], t(2068) = -0.49, p = 0.622;
## Std. beta = -1.45, 95% CI [-7.21, 4.31])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.29, 95% CI [-30.07, 25.48], t(2068) = -0.16, p = 0.871;
## Std. beta = -0.28, 95% CI [-3.73, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.75, 95% CI [-6.97, 3.46], t(2068) = -0.66, p = 0.510; Std.
## beta = -0.22, 95% CI [-0.86, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.73, 95% CI [-37.23, 13.77], t(2068) = -0.90, p = 0.367;
## Std. beta = -1.45, 95% CI [-4.61, 1.71])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-7.33, 11.62], t(2068) = 0.44, p = 0.658; Std.
## beta = 0.27, 95% CI [-0.91, 1.44])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-5.82, 7.52], t(2068) = 0.25, p = 0.802; Std.
## beta = 0.11, 95% CI [-0.72, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.14, 95% CI [-4.22, 14.50], t(2068) = 1.08, p = 0.282; Std.
## beta = 0.64, 95% CI [-0.52, 1.80])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 3.62, 95% CI [-2.05, 9.29], t(2068) = 1.25, p = 0.211; Std.
## beta = 0.45, 95% CI [-0.25, 1.15])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -1.62, 95% CI [-12.22, 8.99], t(2068) = -0.30, p = 0.765; Std.
## beta = -0.20, 95% CI [-1.51, 1.11])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.55, 95% CI [-8.43, 1.33], t(2068) = -1.43, p = 0.153; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -5.29, 95% CI [-14.16, 3.59], t(2068) = -1.17, p = 0.243; Std.
## beta = -0.66, 95% CI [-1.75, 0.44])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.48, 95% CI [-35.12, 16.15], t(2068) = -0.73, p = 0.468;
## Std. beta = -1.17, 95% CI [-4.35, 2.00])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -4.05, 95% CI [-14.25, 6.14], t(2068) = -0.78, p = 0.436; Std.
## beta = -0.50, 95% CI [-1.76, 0.76])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.03, 95% CI [-2.82, 4.89], t(2068) = 0.53, p = 0.598; Std.
## beta = 0.13, 95% CI [-0.35, 0.61])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.67, 95% CI [-8.67, 5.33], t(2068) = -0.47, p = 0.639; Std.
## beta = -0.21, 95% CI [-1.07, 0.66])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.18, 95% CI [-11.70, 3.34], t(2068) = -1.09, p = 0.276; Std.
## beta = -0.52, 95% CI [-1.45, 0.41])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.49, 95% CI [-4.17, 5.14], t(2068) = 0.21, p = 0.837; Std.
## beta = 0.06, 95% CI [-0.52, 0.64])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.18, 95% CI [-0.85, 17.21], t(2068) = 1.78, p = 0.076; Std.
## beta = 1.01, 95% CI [-0.11, 2.13])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.86, 95% CI [-0.94, 10.66], t(2068) = 1.64, p = 0.100; Std.
## beta = 0.60, 95% CI [-0.12, 1.32])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.86, 95% CI [-7.48, 3.76], t(2068) = -0.65, p = 0.516; Std.
## beta = -0.23, 95% CI [-0.93, 0.47])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.32, 95% CI [-6.04, 1.40], t(2068) = -1.22, p = 0.222; Std.
## beta = -0.29, 95% CI [-0.75, 0.17])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.21, 95% CI [-50.69, -9.73], t(2068) = -2.89, p = 0.004;
## Std. beta = -3.74, 95% CI [-6.28, -1.21])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-7.33, 10.63], t(2068) = 0.36, p = 0.718; Std.
## beta = 0.20, 95% CI [-0.91, 1.32])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.03, 95% CI [-10.07, 16.13], t(2068) = 0.45, p = 0.650; Std.
## beta = 0.38, 95% CI [-1.25, 2.00])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.18, 95% CI [-14.83, 8.47], t(2068) = -0.53, p = 0.593; Std.
## beta = -0.39, 95% CI [-1.84, 1.05])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*SS_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14886.9
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1207 -0.4893 -0.0068 0.4452 7.0958
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 138.99 11.789
## time_firstPFT 11.14 3.338 -0.29
## Residual 41.84 6.469
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 39.02615 4.99053 7.820
## time_firstPFT -3.21638 2.23611 -1.438
## SS_5yrPreCensor -6.34125 5.50907 -1.151
## disadv -5.64149 2.34448 -2.406
## dich_RaceNon-White -3.03463 2.28237 -1.330
## sexF -2.54122 1.41650 -1.794
## age_dx 0.13883 0.07413 1.873
## smokeHxFormer -2.74239 1.41437 -1.939
## smokeHxAlways 9.18867 7.06944 1.300
## smokeHxUnknown -2.75786 3.18903 -0.865
## site02R 8.92472 18.53265 0.482
## site03R 21.11241 9.89805 2.133
## site04R -4.55636 9.17739 -0.496
## site05R -13.30063 7.72690 -1.721
## site06R -8.03944 13.50456 -0.595
## site07R 3.98606 3.69177 1.080
## site09R -9.18530 9.43778 -0.973
## site101 20.61678 2.53728 8.126
## site102 7.16607 4.99451 1.435
## site103 -1.01289 2.29086 -0.442
## site104 -7.98854 5.14633 -1.552
## site105 2.58234 2.50161 1.032
## site106 -5.13353 3.42346 -1.500
## site107 8.34802 9.53134 0.876
## site108 -3.17338 7.81340 -0.406
## site10R 2.78249 15.64028 0.178
## site11R -0.79753 5.72650 -0.139
## site12R -7.95992 9.26805 -0.859
## site13R -11.49790 7.27445 -1.581
## site14R -7.24151 14.97614 -0.484
## site15R -19.54967 13.54929 -1.443
## site16R -6.56746 6.00617 -1.093
## site17R 63.54318 13.63630 4.660
## site18R -1.15626 9.74907 -0.119
## site19R -6.39184 6.09522 -1.049
## site20R -3.42283 5.53951 -0.618
## site21R -11.99801 12.56736 -0.955
## site22R -12.38300 4.39923 -2.815
## site23R -24.03353 7.72074 -3.113
## site24R 1.56332 4.99941 0.313
## site25R 0.16342 9.21813 0.018
## site28R -15.57096 7.88579 -1.975
## site29R -0.55713 13.34778 -0.042
## site31R -0.29668 5.78449 -0.051
## site32R 5.99698 6.63367 0.904
## site33R -6.77068 6.78021 -0.999
## site34R -4.28871 4.95097 -0.866
## site35R -13.60562 7.78652 -1.747
## site36R 3.34525 5.92062 0.565
## site37R 0.79428 6.52536 0.122
## site38R -0.70161 4.38738 -0.160
## site39R 14.06489 13.38544 1.051
## site40R 1.58923 9.28371 0.171
## site41R -12.92822 7.73826 -1.671
## site42R -9.74423 4.37907 -2.225
## time_firstPFT:SS_5yrPreCensor 2.43384 2.81209 0.865
## time_firstPFT:disadv 1.49490 1.10709 1.350
## time_firstPFT:dich_RaceNon-White -0.58372 1.11383 -0.524
## time_firstPFT:sexF 0.72600 0.65617 1.106
## time_firstPFT:age_dx -0.03946 0.03437 -1.148
## time_firstPFT:smokeHxFormer -0.67622 0.67351 -1.004
## time_firstPFT:smokeHxAlways -6.24985 6.04387 -1.034
## time_firstPFT:smokeHxUnknown 2.15075 1.67212 1.286
## time_firstPFT:site02R -38.71181 19.69570 -1.965
## time_firstPFT:site03R -0.86419 5.98360 -0.144
## time_firstPFT:site04R -2.63981 6.29402 -0.419
## time_firstPFT:site05R -3.31903 7.57445 -0.438
## time_firstPFT:site07R -2.23662 1.45642 -1.536
## time_firstPFT:site09R 1.42778 4.28729 0.333
## time_firstPFT:site101 -0.98419 1.08828 -0.904
## time_firstPFT:site102 -0.76236 2.21829 -0.344
## time_firstPFT:site103 1.33129 1.01815 1.308
## time_firstPFT:site104 1.65268 3.78442 0.437
## time_firstPFT:site105 -0.28279 1.08541 -0.261
## time_firstPFT:site106 1.65465 1.65872 0.998
## time_firstPFT:site107 -12.71441 8.17511 -1.555
## time_firstPFT:site108 4.69871 3.60040 1.305
## time_firstPFT:site11R 5.34455 2.84126 1.881
## time_firstPFT:site12R 1.90106 4.03672 0.471
## time_firstPFT:site13R -0.53304 3.97509 -0.134
## time_firstPFT:site14R -10.40444 23.71611 -0.439
## time_firstPFT:site15R -2.54391 14.17639 -0.179
## time_firstPFT:site16R -1.81437 2.71225 -0.669
## time_firstPFT:site18R -11.51204 13.01965 -0.884
## time_firstPFT:site19R 2.21024 4.89659 0.451
## time_firstPFT:site20R 0.77640 3.44013 0.226
## time_firstPFT:site21R 5.80582 4.77013 1.217
## time_firstPFT:site22R 4.90251 2.94911 1.662
## time_firstPFT:site23R 22.24237 26.79822 0.830
## time_firstPFT:site24R -3.07929 2.49550 -1.234
## time_firstPFT:site25R -4.38880 4.58596 -0.957
## time_firstPFT:site28R -8.49194 13.15250 -0.646
## time_firstPFT:site29R -2.34847 5.23583 -0.449
## time_firstPFT:site31R 1.90191 2.00696 0.948
## time_firstPFT:site32R -1.08226 3.59965 -0.301
## time_firstPFT:site33R -4.60815 3.89719 -1.182
## time_firstPFT:site34R 0.70924 2.40870 0.294
## time_firstPFT:site35R 9.13013 4.65122 1.963
## time_firstPFT:site36R 5.02224 2.97611 1.688
## time_firstPFT:site37R -1.38236 2.96004 -0.467
## time_firstPFT:site38R -2.17687 1.90694 -1.142
## time_firstPFT:site39R -30.24438 10.51441 -2.876
## time_firstPFT:site40R 1.38430 4.63118 0.299
## time_firstPFT:site41R 3.97279 6.69990 0.593
## time_firstPFT:site42R -3.44301 5.96652 -0.577##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.800
## Unadjusted ICC: 0.528report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## SS_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 39.03 (95% CI [29.24, 48.81], t(2038)
## = 7.82, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## SS_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to
## SS_5yrPreCensor = 0, is at 39.03 (95% CI [29.24, 48.81], t(2038) = 7.82, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to disadv = 0, is at 39.03 (95% CI [29.24,
## 48.81], t(2038) = 7.82, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to dich_Race =
## White, is at 39.03 (95% CI [29.24, 48.81], t(2038) = 7.82, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 39.03 (95% CI [29.24,
## 48.81], t(2038) = 7.82, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to age_dx = 0, is at 39.03 (95% CI [29.24,
## 48.81], t(2038) = 7.82, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to smokeHx =
## Never, is at 39.03 (95% CI [29.24, 48.81], t(2038) = 7.82, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 39.03 (95% CI [29.24,
## 48.81], t(2038) = 7.82, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * SS_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 39.03 (95% CI [29.24, 48.81], t(2038) = 7.82, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.22, 95% CI [-7.60, 1.17], t(2038) = -1.44, p = 0.150; Std. beta =
## -0.53, 95% CI [-0.72, -0.34])
## - The effect of SS 5yrPreCensor is statistically non-significant and negative
## (beta = -6.34, 95% CI [-17.15, 4.46], t(2038) = -1.15, p = 0.250; Std. beta =
## -0.03, 95% CI [-0.18, 0.11])
## - The effect of disadv is statistically significant and negative (beta = -5.64,
## 95% CI [-10.24, -1.04], t(2038) = -2.41, p = 0.016; Std. beta = -0.07, 95% CI
## [-0.16, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -3.03, 95% CI [-7.51, 1.44], t(2038) = -1.33, p = 0.184; Std.
## beta = -0.27, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.54, 95% CI [-5.32, 0.24], t(2038) = -1.79, p = 0.073; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.54e-03, 0.28], t(2038) = 1.87, p = 0.061; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically non-significant and negative
## (beta = -2.74, 95% CI [-5.52, 0.03], t(2038) = -1.94, p = 0.053; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.19, 95% CI [-4.68, 23.05], t(2038) = 1.30, p = 0.194; Std. beta =
## -0.02, 95% CI [-1.28, 1.23])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.76, 95% CI [-9.01, 3.50], t(2038) = -0.86, p = 0.387; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and positive (beta
## = 8.92, 95% CI [-27.42, 45.27], t(2038) = 0.48, p = 0.630; Std. beta = -3.39,
## 95% CI [-7.22, 0.45])
## - The effect of site [03R] is statistically significant and positive (beta =
## 21.11, 95% CI [1.70, 40.52], t(2038) = 2.13, p = 0.033; Std. beta = 1.35, 95%
## CI [0.07, 2.62])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.56, 95% CI [-22.55, 13.44], t(2038) = -0.50, p = 0.620; Std. beta = -0.58,
## 95% CI [-2.03, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.30, 95% CI [-28.45, 1.85], t(2038) = -1.72, p = 0.085; Std. beta = -1.25,
## 95% CI [-2.74, 0.25])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -8.04, 95% CI [-34.52, 18.44], t(2038) = -0.60, p = 0.552; Std. beta = -0.55,
## 95% CI [-2.35, 1.25])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.99, 95% CI [-3.25, 11.23], t(2038) = 1.08, p = 0.280; Std. beta = 0.04, 95%
## CI [-0.43, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.19, 95% CI [-27.69, 9.32], t(2038) = -0.97, p = 0.331; Std. beta = -0.48,
## 95% CI [-1.76, 0.80])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.62, 95% CI [15.64, 25.59], t(2038) = 8.13, p < .001; Std. beta = 1.30, 95%
## CI [0.96, 1.64])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.17, 95% CI [-2.63, 16.96], t(2038) = 1.43, p = 0.152; Std. beta = 0.41, 95%
## CI [-0.25, 1.06])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -1.01, 95% CI [-5.51, 3.48], t(2038) = -0.44, p = 0.658; Std. beta = 0.07,
## 95% CI [-0.24, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-18.08, 2.10], t(2038) = -1.55, p = 0.121; Std. beta = -0.37,
## 95% CI [-1.24, 0.50])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 2.58, 95% CI [-2.32, 7.49], t(2038) = 1.03, p = 0.302; Std. beta = 0.15, 95%
## CI [-0.18, 0.48])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.13, 95% CI [-11.85, 1.58], t(2038) = -1.50, p = 0.134; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 8.35, 95% CI [-10.34, 27.04], t(2038) = 0.88, p = 0.381; Std. beta = -0.74,
## 95% CI [-2.37, 0.89])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -3.17, 95% CI [-18.50, 12.15], t(2038) = -0.41, p = 0.685; Std. beta = 0.27,
## 95% CI [-0.75, 1.28])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 2.78, 95% CI [-27.89, 33.46], t(2038) = 0.18, p = 0.859; Std. beta = 0.19,
## 95% CI [-1.90, 2.27])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.03, 10.43], t(2038) = -0.14, p = 0.889; Std. beta = 0.50,
## 95% CI [-0.30, 1.30])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.96, 95% CI [-26.14, 10.22], t(2038) = -0.86, p = 0.391; Std. beta = -0.34,
## 95% CI [-1.61, 0.92])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.50, 95% CI [-25.76, 2.77], t(2038) = -1.58, p = 0.114; Std. beta = -0.84,
## 95% CI [-1.80, 0.12])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.24, 95% CI [-36.61, 22.13], t(2038) = -0.48, p = 0.629; Std. beta = -1.57,
## 95% CI [-5.00, 1.87])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.55, 95% CI [-46.12, 7.02], t(2038) = -1.44, p = 0.149; Std. beta = -1.59,
## 95% CI [-4.23, 1.04])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -6.57, 95% CI [-18.35, 5.21], t(2038) = -1.09, p = 0.274; Std. beta = -0.63,
## 95% CI [-1.46, 0.19])
## - The effect of site [17R] is statistically significant and positive (beta =
## 63.54, 95% CI [36.80, 90.29], t(2038) = 4.66, p < .001; Std. beta = 4.32, 95%
## CI [2.50, 6.13])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.16, 95% CI [-20.28, 17.96], t(2038) = -0.12, p = 0.906; Std. beta = -1.27,
## 95% CI [-3.80, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -6.39, 95% CI [-18.35, 5.56], t(2038) = -1.05, p = 0.294; Std. beta = -0.21,
## 95% CI [-1.26, 0.85])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -3.42, 95% CI [-14.29, 7.44], t(2038) = -0.62, p = 0.537; Std. beta = -0.15,
## 95% CI [-0.97, 0.66])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -12.00, 95% CI [-36.64, 12.65], t(2038) = -0.95, p = 0.340; Std. beta =
## -0.22, 95% CI [-1.79, 1.36])
## - The effect of site [22R] is statistically significant and negative (beta =
## -12.38, 95% CI [-21.01, -3.76], t(2038) = -2.81, p = 0.005; Std. beta = -0.34,
## 95% CI [-1.00, 0.33])
## - The effect of site [23R] is statistically significant and negative (beta =
## -24.03, 95% CI [-39.17, -8.89], t(2038) = -3.11, p = 0.002; Std. beta = 0.66,
## 95% CI [-4.33, 5.66])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.56, 95% CI [-8.24, 11.37], t(2038) = 0.31, p = 0.755; Std. beta = -0.21,
## 95% CI [-0.88, 0.46])
## - The effect of site [25R] is statistically non-significant and positive (beta
## = 0.16, 95% CI [-17.91, 18.24], t(2038) = 0.02, p = 0.986; Std. beta = -0.44,
## 95% CI [-1.67, 0.78])
## - The effect of site [28R] is statistically significant and negative (beta =
## -15.57, 95% CI [-31.04, -0.11], t(2038) = -1.97, p = 0.048; Std. beta = -1.93,
## 95% CI [-4.53, 0.66])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.56, 95% CI [-26.73, 25.62], t(2038) = -0.04, p = 0.967; Std. beta = -0.28,
## 95% CI [-1.91, 1.35])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.30, 95% CI [-11.64, 11.05], t(2038) = -0.05, p = 0.959; Std. beta = 0.18,
## 95% CI [-0.55, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 6.00, 95% CI [-7.01, 19.01], t(2038) = 0.90, p = 0.366; Std. beta = 0.30, 95%
## CI [-0.63, 1.23])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -6.77, 95% CI [-20.07, 6.53], t(2038) = -1.00, p = 0.318; Std. beta = -0.94,
## 95% CI [-1.95, 0.08])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -4.29, 95% CI [-14.00, 5.42], t(2038) = -0.87, p = 0.386; Std. beta = -0.22,
## 95% CI [-0.89, 0.45])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.61, 95% CI [-28.88, 1.66], t(2038) = -1.75, p = 0.081; Std. beta = 0.02,
## 95% CI [-1.08, 1.12])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.35, 95% CI [-8.27, 14.96], t(2038) = 0.57, p = 0.572; Std. beta = 0.75, 95%
## CI [-0.09, 1.58])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.79, 95% CI [-12.00, 13.59], t(2038) = 0.12, p = 0.903; Std. beta = -0.09,
## 95% CI [-0.95, 0.77])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -0.70, 95% CI [-9.31, 7.90], t(2038) = -0.16, p = 0.873; Std. beta = -0.27,
## 95% CI [-0.84, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 14.06, 95% CI [-12.19, 40.32], t(2038) = 1.05, p = 0.293; Std. beta = -2.16,
## 95% CI [-4.35, 0.02])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.59, 95% CI [-16.62, 19.80], t(2038) = 0.17, p = 0.864; Std. beta = 0.25,
## 95% CI [-1.08, 1.58])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -12.93, 95% CI [-28.10, 2.25], t(2038) = -1.67, p = 0.095; Std. beta = -0.47,
## 95% CI [-1.84, 0.91])
## - The effect of site [42R] is statistically significant and negative (beta =
## -9.74, 95% CI [-18.33, -1.16], t(2038) = -2.23, p = 0.026; Std. beta = -1.02,
## 95% CI [-2.12, 0.09])
## - The effect of time firstPFT × SS 5yrPreCensor is statistically
## non-significant and positive (beta = 2.43, 95% CI [-3.08, 7.95], t(2038) =
## 0.87, p = 0.387; Std. beta = 0.06, 95% CI [-0.07, 0.19])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.49, 95% CI [-0.68, 3.67], t(2038) = 1.35, p = 0.177; Std.
## beta = 0.05, 95% CI [-0.02, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.58, 95% CI [-2.77, 1.60], t(2038) =
## -0.52, p = 0.600; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.73, 95% CI [-0.56, 2.01], t(2038) = 1.11, p = 0.269; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.15, p = 0.251; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.68, 95% CI [-2.00, 0.64], t(2038) =
## -1.00, p = 0.315; Std. beta = -0.08, 95% CI [-0.25, 0.08])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.25, 95% CI [-18.10, 5.60], t(2038) =
## -1.03, p = 0.301; Std. beta = -0.78, 95% CI [-2.25, 0.70])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.15, 95% CI [-1.13, 5.43], t(2038) =
## 1.29, p = 0.199; Std. beta = 0.27, 95% CI [-0.14, 0.67])
## - The effect of time firstPFT × site [02R] is statistically significant and
## negative (beta = -38.71, 95% CI [-77.34, -0.09], t(2038) = -1.97, p = 0.049;
## Std. beta = -4.80, 95% CI [-9.60, -0.01])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -0.86, 95% CI [-12.60, 10.87], t(2038) = -0.14, p = 0.885;
## Std. beta = -0.11, 95% CI [-1.56, 1.35])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.64, 95% CI [-14.98, 9.70], t(2038) = -0.42, p = 0.675; Std.
## beta = -0.33, 95% CI [-1.86, 1.20])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.32, 95% CI [-18.17, 11.54], t(2038) = -0.44, p = 0.661;
## Std. beta = -0.41, 95% CI [-2.25, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.24, 95% CI [-5.09, 0.62], t(2038) = -1.54, p = 0.125; Std.
## beta = -0.28, 95% CI [-0.63, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 1.43, 95% CI [-6.98, 9.84], t(2038) = 0.33, p = 0.739; Std.
## beta = 0.18, 95% CI [-0.87, 1.22])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.98, 95% CI [-3.12, 1.15], t(2038) = -0.90, p = 0.366; Std.
## beta = -0.12, 95% CI [-0.39, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.76, 95% CI [-5.11, 3.59], t(2038) = -0.34, p = 0.731; Std.
## beta = -0.09, 95% CI [-0.63, 0.45])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-0.67, 3.33], t(2038) = 1.31, p = 0.191; Std.
## beta = 0.17, 95% CI [-0.08, 0.41])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-5.77, 9.07], t(2038) = 0.44, p = 0.662; Std.
## beta = 0.21, 95% CI [-0.72, 1.13])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -0.28, 95% CI [-2.41, 1.85], t(2038) = -0.26, p = 0.794; Std.
## beta = -0.04, 95% CI [-0.30, 0.23])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.65, 95% CI [-1.60, 4.91], t(2038) = 1.00, p = 0.319; Std.
## beta = 0.21, 95% CI [-0.20, 0.61])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.71, 95% CI [-28.75, 3.32], t(2038) = -1.56, p = 0.120;
## Std. beta = -1.58, 95% CI [-3.57, 0.41])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.70, 95% CI [-2.36, 11.76], t(2038) = 1.31, p = 0.192; Std.
## beta = 0.58, 95% CI [-0.29, 1.46])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.34, 95% CI [-0.23, 10.92], t(2038) = 1.88, p = 0.060; Std.
## beta = 0.66, 95% CI [-0.03, 1.35])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-6.02, 9.82], t(2038) = 0.47, p = 0.638; Std.
## beta = 0.24, 95% CI [-0.75, 1.22])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.53, 95% CI [-8.33, 7.26], t(2038) = -0.13, p = 0.893; Std.
## beta = -0.07, 95% CI [-1.03, 0.90])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.40, 95% CI [-56.91, 36.11], t(2038) = -0.44, p = 0.661;
## Std. beta = -1.29, 95% CI [-7.06, 4.48])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.54, 95% CI [-30.35, 25.26], t(2038) = -0.18, p = 0.858;
## Std. beta = -0.32, 95% CI [-3.77, 3.13])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.81, 95% CI [-7.13, 3.50], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.23, 95% CI [-0.89, 0.43])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.51, 95% CI [-37.05, 14.02], t(2038) = -0.88, p = 0.377;
## Std. beta = -1.43, 95% CI [-4.60, 1.74])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 2.21, 95% CI [-7.39, 11.81], t(2038) = 0.45, p = 0.652; Std.
## beta = 0.27, 95% CI [-0.92, 1.47])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.78, 95% CI [-5.97, 7.52], t(2038) = 0.23, p = 0.821; Std.
## beta = 0.10, 95% CI [-0.74, 0.93])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.81, 95% CI [-3.55, 15.16], t(2038) = 1.22, p = 0.224; Std.
## beta = 0.72, 95% CI [-0.44, 1.88])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.90, 95% CI [-0.88, 10.69], t(2038) = 1.66, p = 0.097; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 22.24, 95% CI [-30.31, 74.80], t(2038) = 0.83, p = 0.407; Std.
## beta = 2.76, 95% CI [-3.76, 9.28])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.08, 95% CI [-7.97, 1.81], t(2038) = -1.23, p = 0.217; Std.
## beta = -0.38, 95% CI [-0.99, 0.23])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -4.39, 95% CI [-13.38, 4.60], t(2038) = -0.96, p = 0.339; Std.
## beta = -0.54, 95% CI [-1.66, 0.57])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.49, 95% CI [-34.29, 17.30], t(2038) = -0.65, p = 0.519;
## Std. beta = -1.05, 95% CI [-4.25, 2.15])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.35, 95% CI [-12.62, 7.92], t(2038) = -0.45, p = 0.654; Std.
## beta = -0.29, 95% CI [-1.57, 0.98])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.90, 95% CI [-2.03, 5.84], t(2038) = 0.95, p = 0.343; Std.
## beta = 0.24, 95% CI [-0.25, 0.72])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -1.08, 95% CI [-8.14, 5.98], t(2038) = -0.30, p = 0.764; Std.
## beta = -0.13, 95% CI [-1.01, 0.74])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.61, 95% CI [-12.25, 3.03], t(2038) = -1.18, p = 0.237; Std.
## beta = -0.57, 95% CI [-1.52, 0.38])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-4.01, 5.43], t(2038) = 0.29, p = 0.768; Std.
## beta = 0.09, 95% CI [-0.50, 0.67])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.13, 95% CI [8.48e-03, 18.25], t(2038) = 1.96, p = 0.050;
## Std. beta = 1.13, 95% CI [1.05e-03, 2.26])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 5.02, 95% CI [-0.81, 10.86], t(2038) = 1.69, p = 0.092; Std.
## beta = 0.62, 95% CI [-0.10, 1.35])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.38, 95% CI [-7.19, 4.42], t(2038) = -0.47, p = 0.641; Std.
## beta = -0.17, 95% CI [-0.89, 0.55])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.18, 95% CI [-5.92, 1.56], t(2038) = -1.14, p = 0.254; Std.
## beta = -0.27, 95% CI [-0.73, 0.19])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.24, 95% CI [-50.86, -9.62], t(2038) = -2.88, p = 0.004;
## Std. beta = -3.75, 95% CI [-6.31, -1.19])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.38, 95% CI [-7.70, 10.47], t(2038) = 0.30, p = 0.765; Std.
## beta = 0.17, 95% CI [-0.96, 1.30])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.97, 95% CI [-9.17, 17.11], t(2038) = 0.59, p = 0.553; Std.
## beta = 0.49, 95% CI [-1.14, 2.12])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.44, 95% CI [-15.14, 8.26], t(2038) = -0.58, p = 0.564; Std.
## beta = -0.43, 95% CI [-1.88, 1.02])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer1 <- lmer(dlco_pct ~ 1 + time_firstPFT*Soil_5yrPreCensor + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientssummary(DLCO_lmer1)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 15061.3
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1379 -0.4983 -0.0082 0.4445 7.0970
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 144.12 12.005
## time_firstPFT 11.08 3.329 -0.31
## Residual 41.85 6.469
## Number of obs: 2164, groups: ID, 462
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 42.495976 2.263441 18.775
## time_firstPFT -5.331948 1.104932 -4.826
## Soil_5yrPreCensor -4.550448 4.166075 -1.092
## site02R -1.944669 13.616936 -0.143
## site03R 27.843043 10.124584 2.750
## site04R -4.889371 9.295163 -0.526
## site05R -12.739536 7.786320 -1.636
## site06R 6.079765 9.742735 0.624
## site07R 5.830071 3.692953 1.579
## site09R -9.013422 9.470428 -0.952
## site101 19.955917 2.557769 7.802
## site102 8.648126 4.972127 1.739
## site103 -2.616935 2.383428 -1.098
## site104 -10.428292 5.319543 -1.960
## site105 1.214682 2.586142 0.470
## site106 -3.301261 3.370010 -0.980
## site107 9.862771 9.662600 1.021
## site108 -7.994272 7.531892 -1.061
## site10R -0.791439 13.378258 -0.059
## site11R 1.320108 5.892630 0.224
## site12R -8.850668 9.365834 -0.945
## site13R -10.255651 7.340834 -1.397
## site14R -7.266235 15.034760 -0.483
## site15R -22.978796 13.672177 -1.681
## site16R -8.374056 5.905984 -1.418
## site17R 60.619798 13.698017 4.425
## site18R -2.430193 9.846755 -0.247
## site19R -1.477724 6.856296 -0.216
## site20R -1.732259 5.612113 -0.309
## site21R -11.222833 12.793948 -0.877
## site22R -11.573973 4.326532 -2.675
## site23R -15.316470 6.734076 -2.274
## site24R 2.364516 5.044039 0.469
## site25R -5.919256 5.567767 -1.063
## site28R -16.663542 7.930448 -2.101
## site29R -0.074874 13.378171 -0.006
## site31R -0.195250 5.827547 -0.034
## site32R 12.025302 8.852764 1.358
## site33R -4.448508 7.406191 -0.601
## site34R -5.003357 5.039701 -0.993
## site35R -13.754351 7.885141 -1.744
## site36R 4.287081 5.970753 0.718
## site37R 1.897680 6.520247 0.291
## site38R -1.564428 4.445011 -0.352
## site39R 7.461247 13.307019 0.561
## site40R 3.512089 9.410947 0.373
## site41R -13.022070 7.729777 -1.685
## site42R -8.913389 4.379050 -2.035
## time_firstPFT:Soil_5yrPreCensor 2.184614 2.058863 1.061
## time_firstPFT:site02R -34.761973 18.548986 -1.874
## time_firstPFT:site03R -2.515661 6.076815 -0.414
## time_firstPFT:site04R -2.005375 6.253997 -0.321
## time_firstPFT:site05R -3.522427 7.557314 -0.466
## time_firstPFT:site06R 2.471599 5.067296 0.488
## time_firstPFT:site07R -2.886255 1.399666 -2.062
## time_firstPFT:site09R 0.983783 4.204956 0.234
## time_firstPFT:site101 -0.925273 1.068678 -0.866
## time_firstPFT:site102 -1.468587 2.179828 -0.674
## time_firstPFT:site103 1.608652 1.055979 1.523
## time_firstPFT:site104 2.691246 3.740814 0.719
## time_firstPFT:site105 -0.008689 1.114359 -0.008
## time_firstPFT:site106 1.170062 1.598668 0.732
## time_firstPFT:site107 -13.154578 8.171618 -1.610
## time_firstPFT:site108 3.903772 3.387030 1.153
## time_firstPFT:site11R 4.128746 2.830201 1.459
## time_firstPFT:site12R 1.304886 3.996791 0.326
## time_firstPFT:site13R -0.363347 3.948345 -0.092
## time_firstPFT:site14R -10.694888 23.709609 -0.451
## time_firstPFT:site15R -2.284873 14.162582 -0.161
## time_firstPFT:site16R -1.143246 2.621581 -0.436
## time_firstPFT:site18R -11.941507 13.027001 -0.917
## time_firstPFT:site19R 0.279263 5.172520 0.054
## time_firstPFT:site20R 0.443356 3.392472 0.131
## time_firstPFT:site21R 4.692868 4.776217 0.983
## time_firstPFT:site22R 4.549708 2.790448 1.630
## time_firstPFT:site23R -2.689154 5.543321 -0.485
## time_firstPFT:site24R -3.560986 2.472294 -1.440
## time_firstPFT:site25R -2.154135 2.966536 -0.726
## time_firstPFT:site28R -9.567567 13.079423 -0.731
## time_firstPFT:site29R -2.668250 5.098741 -0.523
## time_firstPFT:site31R 1.404214 1.981000 0.709
## time_firstPFT:site32R -4.709423 4.766096 -0.988
## time_firstPFT:site33R -4.994872 3.955467 -1.263
## time_firstPFT:site34R 0.852588 2.370001 0.360
## time_firstPFT:site35R 8.451757 4.602107 1.836
## time_firstPFT:site36R 4.681375 2.948039 1.588
## time_firstPFT:site37R -1.559959 2.847734 -0.548
## time_firstPFT:site38R -2.110171 1.892014 -1.115
## time_firstPFT:site39R -30.672798 10.431913 -2.940
## time_firstPFT:site40R 1.332572 4.568996 0.292
## time_firstPFT:site41R 3.417684 6.656618 0.513
## time_firstPFT:site42R -2.772386 5.937954 -0.467##
## Correlation matrix not shown by default, as p = 92 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficientsicc(DLCO_lmer1)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.801
## Unadjusted ICC: 0.534report(DLCO_lmer1)## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 4 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## Soil_5yrPreCensor + time_firstPFT * site + cluster(cohort)). The model included
## time_firstPFT as random effects (formula: ~1 + time_firstPFT | ID). The model's
## total explanatory power is substantial (conditional R2 = 0.87) and the part
## related to the fixed effects alone (marginal R2) is of 0.33. The model's
## intercept, corresponding to time_firstPFT = 0, is at 42.50 (95% CI [38.06,
## 46.93], t(2068) = 18.77, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.33, 95% CI [-7.50, -3.17], t(2068) = -4.83, p < .001; Std. beta = -0.54, 95%
## CI [-0.65, -0.42])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -4.55, 95% CI [-12.72, 3.62], t(2068) = -1.09, p = 0.275; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.94, 95% CI [-28.65, 24.76], t(2068) = -0.14, p = 0.886; Std. beta = -3.71,
## 95% CI [-7.11, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.84, 95% CI [7.99, 47.70], t(2068) = 2.75, p = 0.006; Std. beta = 1.64, 95%
## CI [0.32, 2.95])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-23.12, 13.34], t(2068) = -0.53, p = 0.599; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.74, 95% CI [-28.01, 2.53], t(2068) = -1.64, p = 0.102; Std. beta = -1.23,
## 95% CI [-2.72, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.08, 95% CI [-13.03, 25.19], t(2068) = 0.62, p = 0.533; Std. beta = 0.67,
## 95% CI [-0.70, 2.04])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-1.41, 13.07], t(2068) = 1.58, p = 0.115; Std. beta = 0.10, 95%
## CI [-0.37, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-27.59, 9.56], t(2068) = -0.95, p = 0.341; Std. beta = -0.51,
## 95% CI [-1.78, 0.76])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.96, 95% CI [14.94, 24.97], t(2068) = 7.80, p < .001; Std. beta = 1.26, 95%
## CI [0.93, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-1.10, 18.40], t(2068) = 1.74, p = 0.082; Std. beta = 0.44, 95%
## CI [-0.21, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.62, 95% CI [-7.29, 2.06], t(2068) = -1.10, p = 0.272; Std. beta = -0.01,
## 95% CI [-0.33, 0.30])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.43, 95% CI [-20.86, 3.93e-03], t(2068) = -1.96, p = 0.050; Std. beta =
## -0.43, 95% CI [-1.30, 0.44])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-3.86, 6.29], t(2068) = 0.47, p = 0.639; Std. beta = 0.08, 95%
## CI [-0.26, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-9.91, 3.31], t(2068) = -0.98, p = 0.327; Std. beta = -0.10,
## 95% CI [-0.54, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.86, 95% CI [-9.09, 28.81], t(2068) = 1.02, p = 0.308; Std. beta = -0.68,
## 95% CI [-2.31, 0.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.77, 6.78], t(2068) = -1.06, p = 0.289; Std. beta = -0.14,
## 95% CI [-1.10, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-27.03, 25.44], t(2068) = -0.06, p = 0.953; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.32, 95% CI [-10.24, 12.88], t(2068) = 0.22, p = 0.823; Std. beta = 0.51,
## 95% CI [-0.29, 1.32])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.85, 95% CI [-27.22, 9.52], t(2068) = -0.94, p = 0.345; Std. beta = -0.47,
## 95% CI [-1.73, 0.80])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-24.65, 4.14], t(2068) = -1.40, p = 0.163; Std. beta = -0.73,
## 95% CI [-1.69, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-36.75, 22.22], t(2068) = -0.48, p = 0.629; Std. beta = -1.59,
## 95% CI [-5.01, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.98, 95% CI [-49.79, 3.83], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.37, 95% CI [-19.96, 3.21], t(2068) = -1.42, p = 0.156; Std. beta = -0.69,
## 95% CI [-1.49, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.62, 95% CI [33.76, 87.48], t(2068) = 4.43, p < .001; Std. beta = 4.12, 95%
## CI [2.30, 5.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.43, 95% CI [-21.74, 16.88], t(2068) = -0.25, p = 0.805; Std. beta = -1.39,
## 95% CI [-3.93, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.92, 11.97], t(2068) = -0.22, p = 0.829; Std. beta = -0.07,
## 95% CI [-1.21, 1.07])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-12.74, 9.27], t(2068) = -0.31, p = 0.758; Std. beta = -0.07,
## 95% CI [-0.88, 0.74])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-36.31, 13.87], t(2068) = -0.88, p = 0.380; Std. beta =
## -0.28, 95% CI [-1.87, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.57, 95% CI [-20.06, -3.09], t(2068) = -2.68, p = 0.008; Std. beta = -0.32,
## 95% CI [-0.96, 0.32])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.32, 95% CI [-28.52, -2.11], t(2068) = -2.27, p = 0.023; Std. beta = -1.32,
## 95% CI [-2.53, -0.10])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-7.53, 12.26], t(2068) = 0.47, p = 0.639; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.92, 95% CI [-16.84, 5.00], t(2068) = -1.06, p = 0.288; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.66, 95% CI [-32.22, -1.11], t(2068) = -2.10, p = 0.036; Std. beta = -2.12,
## 95% CI [-4.68, 0.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.07, 95% CI [-26.31, 26.16], t(2068) = -5.60e-03, p = 0.996; Std. beta =
## -0.28, 95% CI [-1.89, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-11.62, 11.23], t(2068) = -0.03, p = 0.973; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.03, 95% CI [-5.34, 29.39], t(2068) = 1.36, p = 0.174; Std. beta = 0.33,
## 95% CI [-0.93, 1.60])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-18.97, 10.08], t(2068) = -0.60, p = 0.548; Std. beta = -0.82,
## 95% CI [-1.88, 0.25])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-14.89, 4.88], t(2068) = -0.99, p = 0.321; Std. beta = -0.25,
## 95% CI [-0.92, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.75, 95% CI [-29.22, 1.71], t(2068) = -1.74, p = 0.081; Std. beta = -0.07,
## 95% CI [-1.16, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-7.42, 16.00], t(2068) = 0.72, p = 0.473; Std. beta = 0.77, 95%
## CI [-0.05, 1.60])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-10.89, 14.68], t(2068) = 0.29, p = 0.771; Std. beta = -0.03,
## 95% CI [-0.87, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-10.28, 7.15], t(2068) = -0.35, p = 0.725; Std. beta = -0.32,
## 95% CI [-0.90, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.46, 95% CI [-18.64, 33.56], t(2068) = 0.56, p = 0.575; Std. beta = -2.65,
## 95% CI [-4.80, -0.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-14.94, 21.97], t(2068) = 0.37, p = 0.709; Std. beta = 0.38,
## 95% CI [-0.94, 1.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.18, 2.14], t(2068) = -1.68, p = 0.092; Std. beta = -0.53,
## 95% CI [-1.89, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -8.91, 95% CI [-17.50, -0.33], t(2068) = -2.04, p = 0.042; Std. beta = -0.89,
## 95% CI [-1.98, 0.20])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 2.18, 95% CI [-1.85, 6.22], t(2068) =
## 1.06, p = 0.289; Std. beta = 0.07, 95% CI [-0.06, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.76, 95% CI [-71.14, 1.61], t(2068) = -1.87, p = 0.061;
## Std. beta = -4.31, 95% CI [-8.81, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-14.43, 9.40], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.31, 95% CI [-1.79, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.27, 10.26], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-18.34, 11.30], t(2068) = -0.47, p = 0.641;
## Std. beta = -0.44, 95% CI [-2.27, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-7.47, 12.41], t(2068) = 0.49, p = 0.626; Std.
## beta = 0.31, 95% CI [-0.92, 1.54])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.89, 95% CI [-5.63, -0.14], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-7.26, 9.23], t(2068) = 0.23, p = 0.815; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-3.02, 1.17], t(2068) = -0.87, p = 0.387; Std.
## beta = -0.11, 95% CI [-0.37, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.74, 2.81], t(2068) = -0.67, p = 0.501; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-0.46, 3.68], t(2068) = 1.52, p = 0.128; Std.
## beta = 0.20, 95% CI [-0.06, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-4.64, 10.03], t(2068) = 0.72, p = 0.472; Std.
## beta = 0.33, 95% CI [-0.58, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -8.69e-03, 95% CI [-2.19, 2.18], t(2068) = -7.80e-03, p =
## 0.994; Std. beta = -1.08e-03, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-1.97, 4.31], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.14, 95% CI [-0.24, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.15, 95% CI [-29.18, 2.87], t(2068) = -1.61, p = 0.108;
## Std. beta = -1.63, 95% CI [-3.61, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-2.74, 10.55], t(2068) = 1.15, p = 0.249; Std.
## beta = 0.48, 95% CI [-0.34, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.13, 95% CI [-1.42, 9.68], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.51, 95% CI [-0.18, 1.20])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-6.53, 9.14], t(2068) = 0.33, p = 0.744; Std.
## beta = 0.16, 95% CI [-0.81, 1.13])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-8.11, 7.38], t(2068) = -0.09, p = 0.927; Std.
## beta = -0.05, 95% CI [-1.00, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-57.19, 35.80], t(2068) = -0.45, p = 0.652;
## Std. beta = -1.32, 95% CI [-7.08, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-30.06, 25.49], t(2068) = -0.16, p = 0.872;
## Std. beta = -0.28, 95% CI [-3.72, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-6.28, 4.00], t(2068) = -0.44, p = 0.663; Std.
## beta = -0.14, 95% CI [-0.78, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-37.49, 13.61], t(2068) = -0.92, p = 0.359;
## Std. beta = -1.48, 95% CI [-4.64, 1.69])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.28, 95% CI [-9.86, 10.42], t(2068) = 0.05, p = 0.957; Std.
## beta = 0.03, 95% CI [-1.22, 1.29])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.21, 7.10], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.05, 95% CI [-0.77, 0.88])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-4.67, 14.06], t(2068) = 0.98, p = 0.326; Std.
## beta = 0.58, 95% CI [-0.58, 1.74])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.55, 95% CI [-0.92, 10.02], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.56, 95% CI [-0.11, 1.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-13.56, 8.18], t(2068) = -0.49, p = 0.628; Std.
## beta = -0.33, 95% CI [-1.68, 1.01])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-8.41, 1.29], t(2068) = -1.44, p = 0.150; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.97, 3.66], t(2068) = -0.73, p = 0.468; Std.
## beta = -0.27, 95% CI [-0.99, 0.45])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.22, 16.08], t(2068) = -0.73, p = 0.465;
## Std. beta = -1.19, 95% CI [-4.36, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-12.67, 7.33], t(2068) = -0.52, p = 0.601; Std.
## beta = -0.33, 95% CI [-1.57, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-2.48, 5.29], t(2068) = 0.71, p = 0.479; Std.
## beta = 0.17, 95% CI [-0.31, 0.66])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-14.06, 4.64], t(2068) = -0.99, p = 0.323; Std.
## beta = -0.58, 95% CI [-1.74, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-12.75, 2.76], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.62, 95% CI [-1.58, 0.34])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.80, 5.50], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.11, 95% CI [-0.47, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.45, 95% CI [-0.57, 17.48], t(2068) = 1.84, p = 0.066; Std.
## beta = 1.05, 95% CI [-0.07, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.68, 95% CI [-1.10, 10.46], t(2068) = 1.59, p = 0.112; Std.
## beta = 0.58, 95% CI [-0.14, 1.30])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-7.14, 4.02], t(2068) = -0.55, p = 0.584; Std.
## beta = -0.19, 95% CI [-0.89, 0.50])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-5.82, 1.60], t(2068) = -1.12, p = 0.265; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.67, 95% CI [-51.13, -10.21], t(2068) = -2.94, p = 0.003;
## Std. beta = -3.80, 95% CI [-6.33, -1.27])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-7.63, 10.29], t(2068) = 0.29, p = 0.771; Std.
## beta = 0.17, 95% CI [-0.94, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.42, 95% CI [-9.64, 16.47], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.42, 95% CI [-1.19, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-14.42, 8.87], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.34, 95% CI [-1.79, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## Soil_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to Soil_5yrPreCensor = 0, is at 42.50 (95% CI [38.06, 46.93],
## t(2068) = 18.77, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.33, 95% CI [-7.50, -3.17], t(2068) = -4.83, p < .001; Std. beta = -0.54, 95%
## CI [-0.65, -0.42])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -4.55, 95% CI [-12.72, 3.62], t(2068) = -1.09, p = 0.275; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.94, 95% CI [-28.65, 24.76], t(2068) = -0.14, p = 0.886; Std. beta = -3.71,
## 95% CI [-7.11, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.84, 95% CI [7.99, 47.70], t(2068) = 2.75, p = 0.006; Std. beta = 1.64, 95%
## CI [0.32, 2.95])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-23.12, 13.34], t(2068) = -0.53, p = 0.599; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.74, 95% CI [-28.01, 2.53], t(2068) = -1.64, p = 0.102; Std. beta = -1.23,
## 95% CI [-2.72, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.08, 95% CI [-13.03, 25.19], t(2068) = 0.62, p = 0.533; Std. beta = 0.67,
## 95% CI [-0.70, 2.04])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-1.41, 13.07], t(2068) = 1.58, p = 0.115; Std. beta = 0.10, 95%
## CI [-0.37, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-27.59, 9.56], t(2068) = -0.95, p = 0.341; Std. beta = -0.51,
## 95% CI [-1.78, 0.76])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.96, 95% CI [14.94, 24.97], t(2068) = 7.80, p < .001; Std. beta = 1.26, 95%
## CI [0.93, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-1.10, 18.40], t(2068) = 1.74, p = 0.082; Std. beta = 0.44, 95%
## CI [-0.21, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.62, 95% CI [-7.29, 2.06], t(2068) = -1.10, p = 0.272; Std. beta = -0.01,
## 95% CI [-0.33, 0.30])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.43, 95% CI [-20.86, 3.93e-03], t(2068) = -1.96, p = 0.050; Std. beta =
## -0.43, 95% CI [-1.30, 0.44])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-3.86, 6.29], t(2068) = 0.47, p = 0.639; Std. beta = 0.08, 95%
## CI [-0.26, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-9.91, 3.31], t(2068) = -0.98, p = 0.327; Std. beta = -0.10,
## 95% CI [-0.54, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.86, 95% CI [-9.09, 28.81], t(2068) = 1.02, p = 0.308; Std. beta = -0.68,
## 95% CI [-2.31, 0.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.77, 6.78], t(2068) = -1.06, p = 0.289; Std. beta = -0.14,
## 95% CI [-1.10, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-27.03, 25.44], t(2068) = -0.06, p = 0.953; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.32, 95% CI [-10.24, 12.88], t(2068) = 0.22, p = 0.823; Std. beta = 0.51,
## 95% CI [-0.29, 1.32])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.85, 95% CI [-27.22, 9.52], t(2068) = -0.94, p = 0.345; Std. beta = -0.47,
## 95% CI [-1.73, 0.80])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-24.65, 4.14], t(2068) = -1.40, p = 0.163; Std. beta = -0.73,
## 95% CI [-1.69, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-36.75, 22.22], t(2068) = -0.48, p = 0.629; Std. beta = -1.59,
## 95% CI [-5.01, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.98, 95% CI [-49.79, 3.83], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.37, 95% CI [-19.96, 3.21], t(2068) = -1.42, p = 0.156; Std. beta = -0.69,
## 95% CI [-1.49, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.62, 95% CI [33.76, 87.48], t(2068) = 4.43, p < .001; Std. beta = 4.12, 95%
## CI [2.30, 5.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.43, 95% CI [-21.74, 16.88], t(2068) = -0.25, p = 0.805; Std. beta = -1.39,
## 95% CI [-3.93, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.92, 11.97], t(2068) = -0.22, p = 0.829; Std. beta = -0.07,
## 95% CI [-1.21, 1.07])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-12.74, 9.27], t(2068) = -0.31, p = 0.758; Std. beta = -0.07,
## 95% CI [-0.88, 0.74])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-36.31, 13.87], t(2068) = -0.88, p = 0.380; Std. beta =
## -0.28, 95% CI [-1.87, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.57, 95% CI [-20.06, -3.09], t(2068) = -2.68, p = 0.008; Std. beta = -0.32,
## 95% CI [-0.96, 0.32])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.32, 95% CI [-28.52, -2.11], t(2068) = -2.27, p = 0.023; Std. beta = -1.32,
## 95% CI [-2.53, -0.10])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-7.53, 12.26], t(2068) = 0.47, p = 0.639; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.92, 95% CI [-16.84, 5.00], t(2068) = -1.06, p = 0.288; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.66, 95% CI [-32.22, -1.11], t(2068) = -2.10, p = 0.036; Std. beta = -2.12,
## 95% CI [-4.68, 0.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.07, 95% CI [-26.31, 26.16], t(2068) = -5.60e-03, p = 0.996; Std. beta =
## -0.28, 95% CI [-1.89, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-11.62, 11.23], t(2068) = -0.03, p = 0.973; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.03, 95% CI [-5.34, 29.39], t(2068) = 1.36, p = 0.174; Std. beta = 0.33,
## 95% CI [-0.93, 1.60])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-18.97, 10.08], t(2068) = -0.60, p = 0.548; Std. beta = -0.82,
## 95% CI [-1.88, 0.25])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-14.89, 4.88], t(2068) = -0.99, p = 0.321; Std. beta = -0.25,
## 95% CI [-0.92, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.75, 95% CI [-29.22, 1.71], t(2068) = -1.74, p = 0.081; Std. beta = -0.07,
## 95% CI [-1.16, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-7.42, 16.00], t(2068) = 0.72, p = 0.473; Std. beta = 0.77, 95%
## CI [-0.05, 1.60])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-10.89, 14.68], t(2068) = 0.29, p = 0.771; Std. beta = -0.03,
## 95% CI [-0.87, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-10.28, 7.15], t(2068) = -0.35, p = 0.725; Std. beta = -0.32,
## 95% CI [-0.90, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.46, 95% CI [-18.64, 33.56], t(2068) = 0.56, p = 0.575; Std. beta = -2.65,
## 95% CI [-4.80, -0.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-14.94, 21.97], t(2068) = 0.37, p = 0.709; Std. beta = 0.38,
## 95% CI [-0.94, 1.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.18, 2.14], t(2068) = -1.68, p = 0.092; Std. beta = -0.53,
## 95% CI [-1.89, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -8.91, 95% CI [-17.50, -0.33], t(2068) = -2.04, p = 0.042; Std. beta = -0.89,
## 95% CI [-1.98, 0.20])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 2.18, 95% CI [-1.85, 6.22], t(2068) =
## 1.06, p = 0.289; Std. beta = 0.07, 95% CI [-0.06, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.76, 95% CI [-71.14, 1.61], t(2068) = -1.87, p = 0.061;
## Std. beta = -4.31, 95% CI [-8.81, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-14.43, 9.40], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.31, 95% CI [-1.79, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.27, 10.26], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-18.34, 11.30], t(2068) = -0.47, p = 0.641;
## Std. beta = -0.44, 95% CI [-2.27, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-7.47, 12.41], t(2068) = 0.49, p = 0.626; Std.
## beta = 0.31, 95% CI [-0.92, 1.54])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.89, 95% CI [-5.63, -0.14], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-7.26, 9.23], t(2068) = 0.23, p = 0.815; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-3.02, 1.17], t(2068) = -0.87, p = 0.387; Std.
## beta = -0.11, 95% CI [-0.37, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.74, 2.81], t(2068) = -0.67, p = 0.501; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-0.46, 3.68], t(2068) = 1.52, p = 0.128; Std.
## beta = 0.20, 95% CI [-0.06, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-4.64, 10.03], t(2068) = 0.72, p = 0.472; Std.
## beta = 0.33, 95% CI [-0.58, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -8.69e-03, 95% CI [-2.19, 2.18], t(2068) = -7.80e-03, p =
## 0.994; Std. beta = -1.08e-03, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-1.97, 4.31], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.14, 95% CI [-0.24, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.15, 95% CI [-29.18, 2.87], t(2068) = -1.61, p = 0.108;
## Std. beta = -1.63, 95% CI [-3.61, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-2.74, 10.55], t(2068) = 1.15, p = 0.249; Std.
## beta = 0.48, 95% CI [-0.34, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.13, 95% CI [-1.42, 9.68], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.51, 95% CI [-0.18, 1.20])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-6.53, 9.14], t(2068) = 0.33, p = 0.744; Std.
## beta = 0.16, 95% CI [-0.81, 1.13])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-8.11, 7.38], t(2068) = -0.09, p = 0.927; Std.
## beta = -0.05, 95% CI [-1.00, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-57.19, 35.80], t(2068) = -0.45, p = 0.652;
## Std. beta = -1.32, 95% CI [-7.08, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-30.06, 25.49], t(2068) = -0.16, p = 0.872;
## Std. beta = -0.28, 95% CI [-3.72, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-6.28, 4.00], t(2068) = -0.44, p = 0.663; Std.
## beta = -0.14, 95% CI [-0.78, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-37.49, 13.61], t(2068) = -0.92, p = 0.359;
## Std. beta = -1.48, 95% CI [-4.64, 1.69])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.28, 95% CI [-9.86, 10.42], t(2068) = 0.05, p = 0.957; Std.
## beta = 0.03, 95% CI [-1.22, 1.29])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.21, 7.10], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.05, 95% CI [-0.77, 0.88])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-4.67, 14.06], t(2068) = 0.98, p = 0.326; Std.
## beta = 0.58, 95% CI [-0.58, 1.74])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.55, 95% CI [-0.92, 10.02], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.56, 95% CI [-0.11, 1.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-13.56, 8.18], t(2068) = -0.49, p = 0.628; Std.
## beta = -0.33, 95% CI [-1.68, 1.01])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-8.41, 1.29], t(2068) = -1.44, p = 0.150; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.97, 3.66], t(2068) = -0.73, p = 0.468; Std.
## beta = -0.27, 95% CI [-0.99, 0.45])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.22, 16.08], t(2068) = -0.73, p = 0.465;
## Std. beta = -1.19, 95% CI [-4.36, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-12.67, 7.33], t(2068) = -0.52, p = 0.601; Std.
## beta = -0.33, 95% CI [-1.57, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-2.48, 5.29], t(2068) = 0.71, p = 0.479; Std.
## beta = 0.17, 95% CI [-0.31, 0.66])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-14.06, 4.64], t(2068) = -0.99, p = 0.323; Std.
## beta = -0.58, 95% CI [-1.74, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-12.75, 2.76], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.62, 95% CI [-1.58, 0.34])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.80, 5.50], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.11, 95% CI [-0.47, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.45, 95% CI [-0.57, 17.48], t(2068) = 1.84, p = 0.066; Std.
## beta = 1.05, 95% CI [-0.07, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.68, 95% CI [-1.10, 10.46], t(2068) = 1.59, p = 0.112; Std.
## beta = 0.58, 95% CI [-0.14, 1.30])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-7.14, 4.02], t(2068) = -0.55, p = 0.584; Std.
## beta = -0.19, 95% CI [-0.89, 0.50])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-5.82, 1.60], t(2068) = -1.12, p = 0.265; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.67, 95% CI [-51.13, -10.21], t(2068) = -2.94, p = 0.003;
## Std. beta = -3.80, 95% CI [-6.33, -1.27])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-7.63, 10.29], t(2068) = 0.29, p = 0.771; Std.
## beta = 0.17, 95% CI [-0.94, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.42, 95% CI [-9.64, 16.47], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.42, 95% CI [-1.19, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-14.42, 8.87], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.34, 95% CI [-1.79, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT
## * site + cluster(cohort)). The model included time_firstPFT as random effects
## (formula: ~1 + time_firstPFT | ID). The model's total explanatory power is
## substantial (conditional R2 = 0.87) and the part related to the fixed effects
## alone (marginal R2) is of 0.33. The model's intercept, corresponding to site =
## Simmons, is at 42.50 (95% CI [38.06, 46.93], t(2068) = 18.77, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.33, 95% CI [-7.50, -3.17], t(2068) = -4.83, p < .001; Std. beta = -0.54, 95%
## CI [-0.65, -0.42])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -4.55, 95% CI [-12.72, 3.62], t(2068) = -1.09, p = 0.275; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.94, 95% CI [-28.65, 24.76], t(2068) = -0.14, p = 0.886; Std. beta = -3.71,
## 95% CI [-7.11, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.84, 95% CI [7.99, 47.70], t(2068) = 2.75, p = 0.006; Std. beta = 1.64, 95%
## CI [0.32, 2.95])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-23.12, 13.34], t(2068) = -0.53, p = 0.599; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.74, 95% CI [-28.01, 2.53], t(2068) = -1.64, p = 0.102; Std. beta = -1.23,
## 95% CI [-2.72, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.08, 95% CI [-13.03, 25.19], t(2068) = 0.62, p = 0.533; Std. beta = 0.67,
## 95% CI [-0.70, 2.04])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-1.41, 13.07], t(2068) = 1.58, p = 0.115; Std. beta = 0.10, 95%
## CI [-0.37, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-27.59, 9.56], t(2068) = -0.95, p = 0.341; Std. beta = -0.51,
## 95% CI [-1.78, 0.76])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.96, 95% CI [14.94, 24.97], t(2068) = 7.80, p < .001; Std. beta = 1.26, 95%
## CI [0.93, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-1.10, 18.40], t(2068) = 1.74, p = 0.082; Std. beta = 0.44, 95%
## CI [-0.21, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.62, 95% CI [-7.29, 2.06], t(2068) = -1.10, p = 0.272; Std. beta = -0.01,
## 95% CI [-0.33, 0.30])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.43, 95% CI [-20.86, 3.93e-03], t(2068) = -1.96, p = 0.050; Std. beta =
## -0.43, 95% CI [-1.30, 0.44])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-3.86, 6.29], t(2068) = 0.47, p = 0.639; Std. beta = 0.08, 95%
## CI [-0.26, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-9.91, 3.31], t(2068) = -0.98, p = 0.327; Std. beta = -0.10,
## 95% CI [-0.54, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.86, 95% CI [-9.09, 28.81], t(2068) = 1.02, p = 0.308; Std. beta = -0.68,
## 95% CI [-2.31, 0.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.77, 6.78], t(2068) = -1.06, p = 0.289; Std. beta = -0.14,
## 95% CI [-1.10, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-27.03, 25.44], t(2068) = -0.06, p = 0.953; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.32, 95% CI [-10.24, 12.88], t(2068) = 0.22, p = 0.823; Std. beta = 0.51,
## 95% CI [-0.29, 1.32])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.85, 95% CI [-27.22, 9.52], t(2068) = -0.94, p = 0.345; Std. beta = -0.47,
## 95% CI [-1.73, 0.80])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-24.65, 4.14], t(2068) = -1.40, p = 0.163; Std. beta = -0.73,
## 95% CI [-1.69, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-36.75, 22.22], t(2068) = -0.48, p = 0.629; Std. beta = -1.59,
## 95% CI [-5.01, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.98, 95% CI [-49.79, 3.83], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.37, 95% CI [-19.96, 3.21], t(2068) = -1.42, p = 0.156; Std. beta = -0.69,
## 95% CI [-1.49, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.62, 95% CI [33.76, 87.48], t(2068) = 4.43, p < .001; Std. beta = 4.12, 95%
## CI [2.30, 5.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.43, 95% CI [-21.74, 16.88], t(2068) = -0.25, p = 0.805; Std. beta = -1.39,
## 95% CI [-3.93, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.92, 11.97], t(2068) = -0.22, p = 0.829; Std. beta = -0.07,
## 95% CI [-1.21, 1.07])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-12.74, 9.27], t(2068) = -0.31, p = 0.758; Std. beta = -0.07,
## 95% CI [-0.88, 0.74])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-36.31, 13.87], t(2068) = -0.88, p = 0.380; Std. beta =
## -0.28, 95% CI [-1.87, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.57, 95% CI [-20.06, -3.09], t(2068) = -2.68, p = 0.008; Std. beta = -0.32,
## 95% CI [-0.96, 0.32])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.32, 95% CI [-28.52, -2.11], t(2068) = -2.27, p = 0.023; Std. beta = -1.32,
## 95% CI [-2.53, -0.10])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-7.53, 12.26], t(2068) = 0.47, p = 0.639; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.92, 95% CI [-16.84, 5.00], t(2068) = -1.06, p = 0.288; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.66, 95% CI [-32.22, -1.11], t(2068) = -2.10, p = 0.036; Std. beta = -2.12,
## 95% CI [-4.68, 0.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.07, 95% CI [-26.31, 26.16], t(2068) = -5.60e-03, p = 0.996; Std. beta =
## -0.28, 95% CI [-1.89, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-11.62, 11.23], t(2068) = -0.03, p = 0.973; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.03, 95% CI [-5.34, 29.39], t(2068) = 1.36, p = 0.174; Std. beta = 0.33,
## 95% CI [-0.93, 1.60])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-18.97, 10.08], t(2068) = -0.60, p = 0.548; Std. beta = -0.82,
## 95% CI [-1.88, 0.25])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-14.89, 4.88], t(2068) = -0.99, p = 0.321; Std. beta = -0.25,
## 95% CI [-0.92, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.75, 95% CI [-29.22, 1.71], t(2068) = -1.74, p = 0.081; Std. beta = -0.07,
## 95% CI [-1.16, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-7.42, 16.00], t(2068) = 0.72, p = 0.473; Std. beta = 0.77, 95%
## CI [-0.05, 1.60])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-10.89, 14.68], t(2068) = 0.29, p = 0.771; Std. beta = -0.03,
## 95% CI [-0.87, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-10.28, 7.15], t(2068) = -0.35, p = 0.725; Std. beta = -0.32,
## 95% CI [-0.90, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.46, 95% CI [-18.64, 33.56], t(2068) = 0.56, p = 0.575; Std. beta = -2.65,
## 95% CI [-4.80, -0.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-14.94, 21.97], t(2068) = 0.37, p = 0.709; Std. beta = 0.38,
## 95% CI [-0.94, 1.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.18, 2.14], t(2068) = -1.68, p = 0.092; Std. beta = -0.53,
## 95% CI [-1.89, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -8.91, 95% CI [-17.50, -0.33], t(2068) = -2.04, p = 0.042; Std. beta = -0.89,
## 95% CI [-1.98, 0.20])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 2.18, 95% CI [-1.85, 6.22], t(2068) =
## 1.06, p = 0.289; Std. beta = 0.07, 95% CI [-0.06, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.76, 95% CI [-71.14, 1.61], t(2068) = -1.87, p = 0.061;
## Std. beta = -4.31, 95% CI [-8.81, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-14.43, 9.40], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.31, 95% CI [-1.79, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.27, 10.26], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-18.34, 11.30], t(2068) = -0.47, p = 0.641;
## Std. beta = -0.44, 95% CI [-2.27, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-7.47, 12.41], t(2068) = 0.49, p = 0.626; Std.
## beta = 0.31, 95% CI [-0.92, 1.54])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.89, 95% CI [-5.63, -0.14], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-7.26, 9.23], t(2068) = 0.23, p = 0.815; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-3.02, 1.17], t(2068) = -0.87, p = 0.387; Std.
## beta = -0.11, 95% CI [-0.37, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.74, 2.81], t(2068) = -0.67, p = 0.501; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-0.46, 3.68], t(2068) = 1.52, p = 0.128; Std.
## beta = 0.20, 95% CI [-0.06, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-4.64, 10.03], t(2068) = 0.72, p = 0.472; Std.
## beta = 0.33, 95% CI [-0.58, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -8.69e-03, 95% CI [-2.19, 2.18], t(2068) = -7.80e-03, p =
## 0.994; Std. beta = -1.08e-03, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-1.97, 4.31], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.14, 95% CI [-0.24, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.15, 95% CI [-29.18, 2.87], t(2068) = -1.61, p = 0.108;
## Std. beta = -1.63, 95% CI [-3.61, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-2.74, 10.55], t(2068) = 1.15, p = 0.249; Std.
## beta = 0.48, 95% CI [-0.34, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.13, 95% CI [-1.42, 9.68], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.51, 95% CI [-0.18, 1.20])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-6.53, 9.14], t(2068) = 0.33, p = 0.744; Std.
## beta = 0.16, 95% CI [-0.81, 1.13])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-8.11, 7.38], t(2068) = -0.09, p = 0.927; Std.
## beta = -0.05, 95% CI [-1.00, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-57.19, 35.80], t(2068) = -0.45, p = 0.652;
## Std. beta = -1.32, 95% CI [-7.08, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-30.06, 25.49], t(2068) = -0.16, p = 0.872;
## Std. beta = -0.28, 95% CI [-3.72, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-6.28, 4.00], t(2068) = -0.44, p = 0.663; Std.
## beta = -0.14, 95% CI [-0.78, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-37.49, 13.61], t(2068) = -0.92, p = 0.359;
## Std. beta = -1.48, 95% CI [-4.64, 1.69])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.28, 95% CI [-9.86, 10.42], t(2068) = 0.05, p = 0.957; Std.
## beta = 0.03, 95% CI [-1.22, 1.29])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.21, 7.10], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.05, 95% CI [-0.77, 0.88])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-4.67, 14.06], t(2068) = 0.98, p = 0.326; Std.
## beta = 0.58, 95% CI [-0.58, 1.74])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.55, 95% CI [-0.92, 10.02], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.56, 95% CI [-0.11, 1.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-13.56, 8.18], t(2068) = -0.49, p = 0.628; Std.
## beta = -0.33, 95% CI [-1.68, 1.01])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-8.41, 1.29], t(2068) = -1.44, p = 0.150; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.97, 3.66], t(2068) = -0.73, p = 0.468; Std.
## beta = -0.27, 95% CI [-0.99, 0.45])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.22, 16.08], t(2068) = -0.73, p = 0.465;
## Std. beta = -1.19, 95% CI [-4.36, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-12.67, 7.33], t(2068) = -0.52, p = 0.601; Std.
## beta = -0.33, 95% CI [-1.57, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-2.48, 5.29], t(2068) = 0.71, p = 0.479; Std.
## beta = 0.17, 95% CI [-0.31, 0.66])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-14.06, 4.64], t(2068) = -0.99, p = 0.323; Std.
## beta = -0.58, 95% CI [-1.74, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-12.75, 2.76], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.62, 95% CI [-1.58, 0.34])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.80, 5.50], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.11, 95% CI [-0.47, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.45, 95% CI [-0.57, 17.48], t(2068) = 1.84, p = 0.066; Std.
## beta = 1.05, 95% CI [-0.07, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.68, 95% CI [-1.10, 10.46], t(2068) = 1.59, p = 0.112; Std.
## beta = 0.58, 95% CI [-0.14, 1.30])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-7.14, 4.02], t(2068) = -0.55, p = 0.584; Std.
## beta = -0.19, 95% CI [-0.89, 0.50])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-5.82, 1.60], t(2068) = -1.12, p = 0.265; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.67, 95% CI [-51.13, -10.21], t(2068) = -2.94, p = 0.003;
## Std. beta = -3.80, 95% CI [-6.33, -1.27])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-7.63, 10.29], t(2068) = 0.29, p = 0.771; Std.
## beta = 0.17, 95% CI [-0.94, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.42, 95% CI [-9.64, 16.47], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.42, 95% CI [-1.19, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-14.42, 8.87], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.34, 95% CI [-1.79, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.33. The model's intercept,
## corresponding to cohort = CARE-PF, is at 42.50 (95% CI [38.06, 46.93], t(2068)
## = 18.77, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically significant and negative (beta =
## -5.33, 95% CI [-7.50, -3.17], t(2068) = -4.83, p < .001; Std. beta = -0.54, 95%
## CI [-0.65, -0.42])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -4.55, 95% CI [-12.72, 3.62], t(2068) = -1.09, p = 0.275; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -1.94, 95% CI [-28.65, 24.76], t(2068) = -0.14, p = 0.886; Std. beta = -3.71,
## 95% CI [-7.11, -0.30])
## - The effect of site [03R] is statistically significant and positive (beta =
## 27.84, 95% CI [7.99, 47.70], t(2068) = 2.75, p = 0.006; Std. beta = 1.64, 95%
## CI [0.32, 2.95])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.89, 95% CI [-23.12, 13.34], t(2068) = -0.53, p = 0.599; Std. beta = -0.54,
## 95% CI [-1.98, 0.90])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -12.74, 95% CI [-28.01, 2.53], t(2068) = -1.64, p = 0.102; Std. beta = -1.23,
## 95% CI [-2.72, 0.26])
## - The effect of site [06R] is statistically non-significant and positive (beta
## = 6.08, 95% CI [-13.03, 25.19], t(2068) = 0.62, p = 0.533; Std. beta = 0.67,
## 95% CI [-0.70, 2.04])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 5.83, 95% CI [-1.41, 13.07], t(2068) = 1.58, p = 0.115; Std. beta = 0.10, 95%
## CI [-0.37, 0.57])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -9.01, 95% CI [-27.59, 9.56], t(2068) = -0.95, p = 0.341; Std. beta = -0.51,
## 95% CI [-1.78, 0.76])
## - The effect of site [101] is statistically significant and positive (beta =
## 19.96, 95% CI [14.94, 24.97], t(2068) = 7.80, p < .001; Std. beta = 1.26, 95%
## CI [0.93, 1.60])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 8.65, 95% CI [-1.10, 18.40], t(2068) = 1.74, p = 0.082; Std. beta = 0.44, 95%
## CI [-0.21, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.62, 95% CI [-7.29, 2.06], t(2068) = -1.10, p = 0.272; Std. beta = -0.01,
## 95% CI [-0.33, 0.30])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -10.43, 95% CI [-20.86, 3.93e-03], t(2068) = -1.96, p = 0.050; Std. beta =
## -0.43, 95% CI [-1.30, 0.44])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.21, 95% CI [-3.86, 6.29], t(2068) = 0.47, p = 0.639; Std. beta = 0.08, 95%
## CI [-0.26, 0.42])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -3.30, 95% CI [-9.91, 3.31], t(2068) = -0.98, p = 0.327; Std. beta = -0.10,
## 95% CI [-0.54, 0.33])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 9.86, 95% CI [-9.09, 28.81], t(2068) = 1.02, p = 0.308; Std. beta = -0.68,
## 95% CI [-2.31, 0.95])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -7.99, 95% CI [-22.77, 6.78], t(2068) = -1.06, p = 0.289; Std. beta = -0.14,
## 95% CI [-1.10, 0.82])
## - The effect of site [10R] is statistically non-significant and negative (beta
## = -0.79, 95% CI [-27.03, 25.44], t(2068) = -0.06, p = 0.953; Std. beta = -0.05,
## 95% CI [-1.84, 1.73])
## - The effect of site [11R] is statistically non-significant and positive (beta
## = 1.32, 95% CI [-10.24, 12.88], t(2068) = 0.22, p = 0.823; Std. beta = 0.51,
## 95% CI [-0.29, 1.32])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -8.85, 95% CI [-27.22, 9.52], t(2068) = -0.94, p = 0.345; Std. beta = -0.47,
## 95% CI [-1.73, 0.80])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -10.26, 95% CI [-24.65, 4.14], t(2068) = -1.40, p = 0.163; Std. beta = -0.73,
## 95% CI [-1.69, 0.22])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -7.27, 95% CI [-36.75, 22.22], t(2068) = -0.48, p = 0.629; Std. beta = -1.59,
## 95% CI [-5.01, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -22.98, 95% CI [-49.79, 3.83], t(2068) = -1.68, p = 0.093; Std. beta = -1.80,
## 95% CI [-4.42, 0.83])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.37, 95% CI [-19.96, 3.21], t(2068) = -1.42, p = 0.156; Std. beta = -0.69,
## 95% CI [-1.49, 0.11])
## - The effect of site [17R] is statistically significant and positive (beta =
## 60.62, 95% CI [33.76, 87.48], t(2068) = 4.43, p < .001; Std. beta = 4.12, 95%
## CI [2.30, 5.95])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -2.43, 95% CI [-21.74, 16.88], t(2068) = -0.25, p = 0.805; Std. beta = -1.39,
## 95% CI [-3.93, 1.14])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -1.48, 95% CI [-14.92, 11.97], t(2068) = -0.22, p = 0.829; Std. beta = -0.07,
## 95% CI [-1.21, 1.07])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -1.73, 95% CI [-12.74, 9.27], t(2068) = -0.31, p = 0.758; Std. beta = -0.07,
## 95% CI [-0.88, 0.74])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.22, 95% CI [-36.31, 13.87], t(2068) = -0.88, p = 0.380; Std. beta =
## -0.28, 95% CI [-1.87, 1.31])
## - The effect of site [22R] is statistically significant and negative (beta =
## -11.57, 95% CI [-20.06, -3.09], t(2068) = -2.68, p = 0.008; Std. beta = -0.32,
## 95% CI [-0.96, 0.32])
## - The effect of site [23R] is statistically significant and negative (beta =
## -15.32, 95% CI [-28.52, -2.11], t(2068) = -2.27, p = 0.023; Std. beta = -1.32,
## 95% CI [-2.53, -0.10])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 2.36, 95% CI [-7.53, 12.26], t(2068) = 0.47, p = 0.639; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -5.92, 95% CI [-16.84, 5.00], t(2068) = -1.06, p = 0.288; Std. beta = -0.62,
## 95% CI [-1.37, 0.13])
## - The effect of site [28R] is statistically significant and negative (beta =
## -16.66, 95% CI [-32.22, -1.11], t(2068) = -2.10, p = 0.036; Std. beta = -2.12,
## 95% CI [-4.68, 0.45])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -0.07, 95% CI [-26.31, 26.16], t(2068) = -5.60e-03, p = 0.996; Std. beta =
## -0.28, 95% CI [-1.89, 1.33])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.20, 95% CI [-11.62, 11.23], t(2068) = -0.03, p = 0.973; Std. beta = 0.13,
## 95% CI [-0.59, 0.85])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 12.03, 95% CI [-5.34, 29.39], t(2068) = 1.36, p = 0.174; Std. beta = 0.33,
## 95% CI [-0.93, 1.60])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -4.45, 95% CI [-18.97, 10.08], t(2068) = -0.60, p = 0.548; Std. beta = -0.82,
## 95% CI [-1.88, 0.25])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.00, 95% CI [-14.89, 4.88], t(2068) = -0.99, p = 0.321; Std. beta = -0.25,
## 95% CI [-0.92, 0.42])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -13.75, 95% CI [-29.22, 1.71], t(2068) = -1.74, p = 0.081; Std. beta = -0.07,
## 95% CI [-1.16, 1.03])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 4.29, 95% CI [-7.42, 16.00], t(2068) = 0.72, p = 0.473; Std. beta = 0.77, 95%
## CI [-0.05, 1.60])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 1.90, 95% CI [-10.89, 14.68], t(2068) = 0.29, p = 0.771; Std. beta = -0.03,
## 95% CI [-0.87, 0.81])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-10.28, 7.15], t(2068) = -0.35, p = 0.725; Std. beta = -0.32,
## 95% CI [-0.90, 0.25])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 7.46, 95% CI [-18.64, 33.56], t(2068) = 0.56, p = 0.575; Std. beta = -2.65,
## 95% CI [-4.80, -0.49])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 3.51, 95% CI [-14.94, 21.97], t(2068) = 0.37, p = 0.709; Std. beta = 0.38,
## 95% CI [-0.94, 1.70])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.02, 95% CI [-28.18, 2.14], t(2068) = -1.68, p = 0.092; Std. beta = -0.53,
## 95% CI [-1.89, 0.83])
## - The effect of site [42R] is statistically significant and negative (beta =
## -8.91, 95% CI [-17.50, -0.33], t(2068) = -2.04, p = 0.042; Std. beta = -0.89,
## 95% CI [-1.98, 0.20])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 2.18, 95% CI [-1.85, 6.22], t(2068) =
## 1.06, p = 0.289; Std. beta = 0.07, 95% CI [-0.06, 0.19])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -34.76, 95% CI [-71.14, 1.61], t(2068) = -1.87, p = 0.061;
## Std. beta = -4.31, 95% CI [-8.81, 0.20])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -2.52, 95% CI [-14.43, 9.40], t(2068) = -0.41, p = 0.679; Std.
## beta = -0.31, 95% CI [-1.79, 1.16])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.01, 95% CI [-14.27, 10.26], t(2068) = -0.32, p = 0.749;
## Std. beta = -0.25, 95% CI [-1.77, 1.27])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.52, 95% CI [-18.34, 11.30], t(2068) = -0.47, p = 0.641;
## Std. beta = -0.44, 95% CI [-2.27, 1.40])
## - The effect of time firstPFT × site [06R] is statistically non-significant and
## positive (beta = 2.47, 95% CI [-7.47, 12.41], t(2068) = 0.49, p = 0.626; Std.
## beta = 0.31, 95% CI [-0.92, 1.54])
## - The effect of time firstPFT × site [07R] is statistically significant and
## negative (beta = -2.89, 95% CI [-5.63, -0.14], t(2068) = -2.06, p = 0.039; Std.
## beta = -0.36, 95% CI [-0.70, -0.02])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 0.98, 95% CI [-7.26, 9.23], t(2068) = 0.23, p = 0.815; Std.
## beta = 0.12, 95% CI [-0.90, 1.14])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.93, 95% CI [-3.02, 1.17], t(2068) = -0.87, p = 0.387; Std.
## beta = -0.11, 95% CI [-0.37, 0.14])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -1.47, 95% CI [-5.74, 2.81], t(2068) = -0.67, p = 0.501; Std.
## beta = -0.18, 95% CI [-0.71, 0.35])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.61, 95% CI [-0.46, 3.68], t(2068) = 1.52, p = 0.128; Std.
## beta = 0.20, 95% CI [-0.06, 0.46])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.69, 95% CI [-4.64, 10.03], t(2068) = 0.72, p = 0.472; Std.
## beta = 0.33, 95% CI [-0.58, 1.24])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## negative (beta = -8.69e-03, 95% CI [-2.19, 2.18], t(2068) = -7.80e-03, p =
## 0.994; Std. beta = -1.08e-03, 95% CI [-0.27, 0.27])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.17, 95% CI [-1.97, 4.31], t(2068) = 0.73, p = 0.464; Std.
## beta = 0.14, 95% CI [-0.24, 0.53])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -13.15, 95% CI [-29.18, 2.87], t(2068) = -1.61, p = 0.108;
## Std. beta = -1.63, 95% CI [-3.61, 0.36])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 3.90, 95% CI [-2.74, 10.55], t(2068) = 1.15, p = 0.249; Std.
## beta = 0.48, 95% CI [-0.34, 1.31])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 4.13, 95% CI [-1.42, 9.68], t(2068) = 1.46, p = 0.145; Std.
## beta = 0.51, 95% CI [-0.18, 1.20])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.30, 95% CI [-6.53, 9.14], t(2068) = 0.33, p = 0.744; Std.
## beta = 0.16, 95% CI [-0.81, 1.13])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.36, 95% CI [-8.11, 7.38], t(2068) = -0.09, p = 0.927; Std.
## beta = -0.05, 95% CI [-1.00, 0.91])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -10.69, 95% CI [-57.19, 35.80], t(2068) = -0.45, p = 0.652;
## Std. beta = -1.32, 95% CI [-7.08, 4.43])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.28, 95% CI [-30.06, 25.49], t(2068) = -0.16, p = 0.872;
## Std. beta = -0.28, 95% CI [-3.72, 3.16])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.14, 95% CI [-6.28, 4.00], t(2068) = -0.44, p = 0.663; Std.
## beta = -0.14, 95% CI [-0.78, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.94, 95% CI [-37.49, 13.61], t(2068) = -0.92, p = 0.359;
## Std. beta = -1.48, 95% CI [-4.64, 1.69])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.28, 95% CI [-9.86, 10.42], t(2068) = 0.05, p = 0.957; Std.
## beta = 0.03, 95% CI [-1.22, 1.29])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.21, 7.10], t(2068) = 0.13, p = 0.896; Std.
## beta = 0.05, 95% CI [-0.77, 0.88])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 4.69, 95% CI [-4.67, 14.06], t(2068) = 0.98, p = 0.326; Std.
## beta = 0.58, 95% CI [-0.58, 1.74])
## - The effect of time firstPFT × site [22R] is statistically non-significant and
## positive (beta = 4.55, 95% CI [-0.92, 10.02], t(2068) = 1.63, p = 0.103; Std.
## beta = 0.56, 95% CI [-0.11, 1.24])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## negative (beta = -2.69, 95% CI [-13.56, 8.18], t(2068) = -0.49, p = 0.628; Std.
## beta = -0.33, 95% CI [-1.68, 1.01])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.56, 95% CI [-8.41, 1.29], t(2068) = -1.44, p = 0.150; Std.
## beta = -0.44, 95% CI [-1.04, 0.16])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -2.15, 95% CI [-7.97, 3.66], t(2068) = -0.73, p = 0.468; Std.
## beta = -0.27, 95% CI [-0.99, 0.45])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -9.57, 95% CI [-35.22, 16.08], t(2068) = -0.73, p = 0.465;
## Std. beta = -1.19, 95% CI [-4.36, 1.99])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -2.67, 95% CI [-12.67, 7.33], t(2068) = -0.52, p = 0.601; Std.
## beta = -0.33, 95% CI [-1.57, 0.91])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 1.40, 95% CI [-2.48, 5.29], t(2068) = 0.71, p = 0.479; Std.
## beta = 0.17, 95% CI [-0.31, 0.66])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -4.71, 95% CI [-14.06, 4.64], t(2068) = -0.99, p = 0.323; Std.
## beta = -0.58, 95% CI [-1.74, 0.57])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.99, 95% CI [-12.75, 2.76], t(2068) = -1.26, p = 0.207; Std.
## beta = -0.62, 95% CI [-1.58, 0.34])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 0.85, 95% CI [-3.80, 5.50], t(2068) = 0.36, p = 0.719; Std.
## beta = 0.11, 95% CI [-0.47, 0.68])
## - The effect of time firstPFT × site [35R] is statistically non-significant and
## positive (beta = 8.45, 95% CI [-0.57, 17.48], t(2068) = 1.84, p = 0.066; Std.
## beta = 1.05, 95% CI [-0.07, 2.16])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.68, 95% CI [-1.10, 10.46], t(2068) = 1.59, p = 0.112; Std.
## beta = 0.58, 95% CI [-0.14, 1.30])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.56, 95% CI [-7.14, 4.02], t(2068) = -0.55, p = 0.584; Std.
## beta = -0.19, 95% CI [-0.89, 0.50])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -2.11, 95% CI [-5.82, 1.60], t(2068) = -1.12, p = 0.265; Std.
## beta = -0.26, 95% CI [-0.72, 0.20])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.67, 95% CI [-51.13, -10.21], t(2068) = -2.94, p = 0.003;
## Std. beta = -3.80, 95% CI [-6.33, -1.27])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.33, 95% CI [-7.63, 10.29], t(2068) = 0.29, p = 0.771; Std.
## beta = 0.17, 95% CI [-0.94, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 3.42, 95% CI [-9.64, 16.47], t(2068) = 0.51, p = 0.608; Std.
## beta = 0.42, 95% CI [-1.19, 2.04])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -2.77, 95% CI [-14.42, 8.87], t(2068) = -0.47, p = 0.641; Std.
## beta = -0.34, 95% CI [-1.79, 1.10])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.DLCO_lmer2 <- lmer(dlco_pct ~ 1 + time_firstPFT*Soil_5yrPreCensor + time_firstPFT*disadv + time_firstPFT*dich_Race + time_firstPFT*sex + time_firstPFT*age_dx + time_firstPFT*smokeHx + time_firstPFT*site + cluster(cohort) + (1 + time_firstPFT| ID), data=pft)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## Warning: Some predictor variables are on very different scales: consider
## rescalingsummary(DLCO_lmer2)## Linear mixed model fit by REML ['lmerMod']
## Formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT *
## disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT *
## site + cluster(cohort) + (1 + time_firstPFT | ID)
## Data: pft
##
## REML criterion at convergence: 14888.6
##
## Scaled residuals:
## Min 1Q Median 3Q Max
## -4.1151 -0.4927 -0.0112 0.4466 7.0903
##
## Random effects:
## Groups Name Variance Std.Dev. Corr
## ID (Intercept) 139.01 11.790
## time_firstPFT 11.00 3.316 -0.28
## Residual 41.88 6.472
## Number of obs: 2147, groups: ID, 457
##
## Fixed effects:
## Estimate Std. Error t value
## (Intercept) 39.37103 5.17649 7.606
## time_firstPFT -3.49912 2.37353 -1.474
## Soil_5yrPreCensor -3.58251 4.15018 -0.863
## disadv -5.34022 2.33930 -2.283
## dich_RaceNon-White -2.96296 2.29297 -1.292
## sexF -2.55179 1.41659 -1.801
## age_dx 0.13943 0.07421 1.879
## smokeHxFormer -2.84915 1.41169 -2.018
## smokeHxAlways 9.53086 7.06147 1.350
## smokeHxUnknown -2.88594 3.18598 -0.906
## site02R -5.78579 13.49669 -0.429
## site03R 22.93565 10.10990 2.269
## site04R -4.60776 9.17948 -0.502
## site05R -13.12465 7.72490 -1.699
## site06R -7.16074 13.52853 -0.529
## site07R 3.85520 3.68918 1.045
## site09R -11.24254 9.38546 -1.198
## site101 20.03427 2.57247 7.788
## site102 7.52571 4.97178 1.514
## site103 -2.38805 2.48528 -0.961
## site104 -9.21358 5.30214 -1.738
## site105 1.81240 2.59117 0.699
## site106 -5.45081 3.41145 -1.598
## site107 7.45148 9.57238 0.778
## site108 -2.79488 7.80057 -0.358
## site10R 0.17721 13.40625 0.013
## site11R -0.23770 5.84331 -0.041
## site12R -7.52705 9.25462 -0.813
## site13R -11.90001 7.29200 -1.632
## site14R -9.17440 14.98167 -0.612
## site15R -19.62211 13.55122 -1.448
## site16R -8.11742 5.92862 -1.369
## site17R 64.73006 13.66194 4.738
## site18R -1.55520 9.77018 -0.159
## site19R -3.58325 6.80237 -0.527
## site20R -2.31524 5.56750 -0.416
## site21R -11.32128 12.61309 -0.898
## site22R -14.16041 4.35813 -3.249
## site23R -22.50471 8.17806 -2.752
## site24R 1.75946 4.99443 0.352
## site25R -8.54806 5.57653 -1.533
## site28R -15.36779 7.88711 -1.948
## site29R -3.59362 13.25125 -0.271
## site31R -0.80392 5.82050 -0.138
## site32R 10.69109 8.75548 1.221
## site33R -5.90359 7.33999 -0.804
## site34R -5.01541 4.98885 -1.005
## site35R -14.44990 7.83288 -1.845
## site36R 3.63778 5.92638 0.614
## site37R 0.03879 6.53634 0.006
## site38R -1.06175 4.40254 -0.241
## site39R 15.11915 13.35999 1.132
## site40R 1.48777 9.31685 0.160
## site41R -13.97336 7.70100 -1.814
## site42R -10.82952 4.38587 -2.469
## time_firstPFT:Soil_5yrPreCensor 1.58383 2.10948 0.751
## time_firstPFT:disadv 1.41828 1.10835 1.280
## time_firstPFT:dich_RaceNon-White -0.59420 1.11081 -0.535
## time_firstPFT:sexF 0.71498 0.65455 1.092
## time_firstPFT:age_dx -0.03982 0.03425 -1.163
## time_firstPFT:smokeHxFormer -0.61125 0.67187 -0.910
## time_firstPFT:smokeHxAlways -6.30536 6.04136 -1.044
## time_firstPFT:smokeHxUnknown 2.19685 1.66436 1.320
## time_firstPFT:site02R -33.02728 18.56642 -1.779
## time_firstPFT:site03R -1.66304 6.12420 -0.272
## time_firstPFT:site04R -2.58914 6.28735 -0.412
## time_firstPFT:site05R -3.33905 7.57401 -0.441
## time_firstPFT:site07R -2.18573 1.44744 -1.510
## time_firstPFT:site09R 2.09074 4.23281 0.494
## time_firstPFT:site101 -0.72961 1.09227 -0.668
## time_firstPFT:site102 -0.83266 2.20574 -0.377
## time_firstPFT:site103 1.86701 1.12734 1.656
## time_firstPFT:site104 2.19243 3.80975 0.575
## time_firstPFT:site105 0.06545 1.12590 0.058
## time_firstPFT:site106 1.82462 1.64416 1.110
## time_firstPFT:site107 -12.30952 8.18252 -1.504
## time_firstPFT:site108 4.59675 3.58296 1.283
## time_firstPFT:site11R 5.10390 2.89298 1.764
## time_firstPFT:site12R 1.82885 4.02158 0.455
## time_firstPFT:site13R -0.26528 3.98332 -0.067
## time_firstPFT:site14R -9.57911 23.72533 -0.404
## time_firstPFT:site15R -2.50201 14.17693 -0.176
## time_firstPFT:site16R -1.23599 2.67818 -0.462
## time_firstPFT:site18R -11.40527 13.04629 -0.874
## time_firstPFT:site19R 0.93350 5.24722 0.178
## time_firstPFT:site20R 0.44461 3.43862 0.129
## time_firstPFT:site21R 5.50417 4.78671 1.150
## time_firstPFT:site22R 5.78716 2.83906 2.038
## time_firstPFT:site23R 21.83471 26.84115 0.813
## time_firstPFT:site24R -3.15714 2.48453 -1.271
## time_firstPFT:site25R -1.11108 3.02507 -0.367
## time_firstPFT:site28R -8.58194 13.16016 -0.652
## time_firstPFT:site29R -1.09865 5.13160 -0.214
## time_firstPFT:site31R 2.14150 2.02626 1.057
## time_firstPFT:site32R -3.17065 4.81799 -0.658
## time_firstPFT:site33R -4.93430 4.01229 -1.230
## time_firstPFT:site34R 1.00917 2.41200 0.418
## time_firstPFT:site35R 9.32291 4.65197 2.004
## time_firstPFT:site36R 4.91040 2.97271 1.652
## time_firstPFT:site37R -1.06197 2.95384 -0.360
## time_firstPFT:site38R -1.99144 1.90438 -1.046
## time_firstPFT:site39R -30.66333 10.49965 -2.920
## time_firstPFT:site40R 1.21851 4.62706 0.263
## time_firstPFT:site41R 4.39457 6.68059 0.658
## time_firstPFT:site42R -3.10085 5.95926 -0.520##
## Correlation matrix not shown by default, as p = 105 > 12.
## Use print(x, correlation=TRUE) or
## vcov(x) if you need it## fit warnings:
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## Some predictor variables are on very different scales: consider rescalingicc(DLCO_lmer2)## # Intraclass Correlation Coefficient
##
## Adjusted ICC: 0.800
## Unadjusted ICC: 0.527report(DLCO_lmer2)## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients
## fixed-effect model matrix is rank deficient so dropping 5 columns / coefficients## We fitted a linear mixed model (estimated using REML and nloptwrap optimizer)
## to predict dlco_pct with time_firstPFT (formula: dlco_pct ~ 1 + time_firstPFT *
## Soil_5yrPreCensor + time_firstPFT * disadv + time_firstPFT * dich_Race +
## time_firstPFT * sex + time_firstPFT * age_dx + time_firstPFT * smokeHx +
## time_firstPFT * site + cluster(cohort)). The model included time_firstPFT as
## random effects (formula: ~1 + time_firstPFT | ID). The model's total
## explanatory power is substantial (conditional R2 = 0.87) and the part related
## to the fixed effects alone (marginal R2) is of 0.34. The model's intercept,
## corresponding to time_firstPFT = 0, is at 39.37 (95% CI [29.22, 49.52], t(2038)
## = 7.61, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## Soil_5yrPreCensor (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to
## Soil_5yrPreCensor = 0, is at 39.37 (95% CI [29.22, 49.52], t(2038) = 7.61, p <
## .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## disadv (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to disadv = 0,
## is at 39.37 (95% CI [29.22, 49.52], t(2038) = 7.61, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## dich_Race (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to dich_Race =
## White, is at 39.37 (95% CI [29.22, 49.52], t(2038) = 7.61, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## sex (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to sex = M, is at 39.37 (95% CI [29.22,
## 49.52], t(2038) = 7.61, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## age_dx (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to age_dx = 0,
## is at 39.37 (95% CI [29.22, 49.52], t(2038) = 7.61, p < .001). Within this
## model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## smokeHx (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to smokeHx =
## Never, is at 39.37 (95% CI [29.22, 49.52], t(2038) = 7.61, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation., We fitted a linear mixed
## model (estimated using REML and nloptwrap optimizer) to predict dlco_pct with
## site (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor + time_firstPFT
## * disadv + time_firstPFT * dich_Race + time_firstPFT * sex + time_firstPFT *
## age_dx + time_firstPFT * smokeHx + time_firstPFT * site + cluster(cohort)). The
## model included time_firstPFT as random effects (formula: ~1 + time_firstPFT |
## ID). The model's total explanatory power is substantial (conditional R2 = 0.87)
## and the part related to the fixed effects alone (marginal R2) is of 0.34. The
## model's intercept, corresponding to site = Simmons, is at 39.37 (95% CI [29.22,
## 49.52], t(2038) = 7.61, p < .001). Within this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation. and We fitted a linear
## mixed model (estimated using REML and nloptwrap optimizer) to predict dlco_pct
## with cohort (formula: dlco_pct ~ 1 + time_firstPFT * Soil_5yrPreCensor +
## time_firstPFT * disadv + time_firstPFT * dich_Race + time_firstPFT * sex +
## time_firstPFT * age_dx + time_firstPFT * smokeHx + time_firstPFT * site +
## cluster(cohort)). The model included time_firstPFT as random effects (formula:
## ~1 + time_firstPFT | ID). The model's total explanatory power is substantial
## (conditional R2 = 0.87) and the part related to the fixed effects alone
## (marginal R2) is of 0.34. The model's intercept, corresponding to cohort =
## CARE-PF, is at 39.37 (95% CI [29.22, 49.52], t(2038) = 7.61, p < .001). Within
## this model:
##
## - The effect of time firstPFT is statistically non-significant and negative
## (beta = -3.50, 95% CI [-8.15, 1.16], t(2038) = -1.47, p = 0.141; Std. beta =
## -0.55, 95% CI [-0.74, -0.37])
## - The effect of Soil 5yrPreCensor is statistically non-significant and negative
## (beta = -3.58, 95% CI [-11.72, 4.56], t(2038) = -0.86, p = 0.388; Std. beta =
## -0.02, 95% CI [-0.16, 0.12])
## - The effect of disadv is statistically significant and negative (beta = -5.34,
## 95% CI [-9.93, -0.75], t(2038) = -2.28, p = 0.023; Std. beta = -0.06, 95% CI
## [-0.15, 0.03])
## - The effect of dich Race [Non-White] is statistically non-significant and
## negative (beta = -2.96, 95% CI [-7.46, 1.53], t(2038) = -1.29, p = 0.196; Std.
## beta = -0.26, 95% CI [-0.58, 0.05])
## - The effect of sex [F] is statistically non-significant and negative (beta =
## -2.55, 95% CI [-5.33, 0.23], t(2038) = -1.80, p = 0.072; Std. beta = -0.10, 95%
## CI [-0.29, 0.09])
## - The effect of age dx is statistically non-significant and positive (beta =
## 0.14, 95% CI [-6.10e-03, 0.28], t(2038) = 1.88, p = 0.060; Std. beta = 0.05,
## 95% CI [-0.04, 0.14])
## - The effect of smokeHx [Former] is statistically significant and negative
## (beta = -2.85, 95% CI [-5.62, -0.08], t(2038) = -2.02, p = 0.044; Std. beta =
## -0.26, 95% CI [-0.45, -0.06])
## - The effect of smokeHx [Always] is statistically non-significant and positive
## (beta = 9.53, 95% CI [-4.32, 23.38], t(2038) = 1.35, p = 0.177; Std. beta =
## -2.67e-03, 95% CI [-1.26, 1.25])
## - The effect of smokeHx [Unknown] is statistically non-significant and negative
## (beta = -2.89, 95% CI [-9.13, 3.36], t(2038) = -0.91, p = 0.365; Std. beta =
## 0.03, 95% CI [-0.43, 0.49])
## - The effect of site [02R] is statistically non-significant and negative (beta
## = -5.79, 95% CI [-32.25, 20.68], t(2038) = -0.43, p = 0.668; Std. beta = -3.80,
## 95% CI [-7.22, -0.38])
## - The effect of site [03R] is statistically significant and positive (beta =
## 22.94, 95% CI [3.11, 42.76], t(2038) = 2.27, p = 0.023; Std. beta = 1.39, 95%
## CI [0.06, 2.72])
## - The effect of site [04R] is statistically non-significant and negative (beta
## = -4.61, 95% CI [-22.61, 13.39], t(2038) = -0.50, p = 0.616; Std. beta = -0.58,
## 95% CI [-2.02, 0.86])
## - The effect of site [05R] is statistically non-significant and negative (beta
## = -13.12, 95% CI [-28.27, 2.02], t(2038) = -1.70, p = 0.089; Std. beta = -1.24,
## 95% CI [-2.73, 0.26])
## - The effect of site [06R] is statistically non-significant and negative (beta
## = -7.16, 95% CI [-33.69, 19.37], t(2038) = -0.53, p = 0.597; Std. beta = -0.49,
## 95% CI [-2.29, 1.32])
## - The effect of site [07R] is statistically non-significant and positive (beta
## = 3.86, 95% CI [-3.38, 11.09], t(2038) = 1.05, p = 0.296; Std. beta = 0.04, 95%
## CI [-0.44, 0.51])
## - The effect of site [09R] is statistically non-significant and negative (beta
## = -11.24, 95% CI [-29.65, 7.16], t(2038) = -1.20, p = 0.231; Std. beta = -0.55,
## 95% CI [-1.82, 0.73])
## - The effect of site [101] is statistically significant and positive (beta =
## 20.03, 95% CI [14.99, 25.08], t(2038) = 7.79, p < .001; Std. beta = 1.29, 95%
## CI [0.94, 1.63])
## - The effect of site [102] is statistically non-significant and positive (beta
## = 7.53, 95% CI [-2.22, 17.28], t(2038) = 1.51, p = 0.130; Std. beta = 0.43, 95%
## CI [-0.23, 1.08])
## - The effect of site [103] is statistically non-significant and negative (beta
## = -2.39, 95% CI [-7.26, 2.49], t(2038) = -0.96, p = 0.337; Std. beta = 0.03,
## 95% CI [-0.31, 0.37])
## - The effect of site [104] is statistically non-significant and negative (beta
## = -9.21, 95% CI [-19.61, 1.18], t(2038) = -1.74, p = 0.082; Std. beta = -0.40,
## 95% CI [-1.28, 0.48])
## - The effect of site [105] is statistically non-significant and positive (beta
## = 1.81, 95% CI [-3.27, 6.89], t(2038) = 0.70, p = 0.484; Std. beta = 0.13, 95%
## CI [-0.21, 0.47])
## - The effect of site [106] is statistically non-significant and negative (beta
## = -5.45, 95% CI [-12.14, 1.24], t(2038) = -1.60, p = 0.110; Std. beta = -0.18,
## 95% CI [-0.63, 0.27])
## - The effect of site [107] is statistically non-significant and positive (beta
## = 7.45, 95% CI [-11.32, 26.22], t(2038) = 0.78, p = 0.436; Std. beta = -0.76,
## 95% CI [-2.40, 0.87])
## - The effect of site [108] is statistically non-significant and negative (beta
## = -2.79, 95% CI [-18.09, 12.50], t(2038) = -0.36, p = 0.720; Std. beta = 0.28,
## 95% CI [-0.73, 1.30])
## - The effect of site [10R] is statistically non-significant and positive (beta
## = 0.18, 95% CI [-26.11, 26.47], t(2038) = 0.01, p = 0.989; Std. beta = 0.01,
## 95% CI [-1.77, 1.80])
## - The effect of site [11R] is statistically non-significant and negative (beta
## = -0.24, 95% CI [-11.70, 11.22], t(2038) = -0.04, p = 0.968; Std. beta = 0.51,
## 95% CI [-0.31, 1.33])
## - The effect of site [12R] is statistically non-significant and negative (beta
## = -7.53, 95% CI [-25.68, 10.62], t(2038) = -0.81, p = 0.416; Std. beta = -0.32,
## 95% CI [-1.59, 0.95])
## - The effect of site [13R] is statistically non-significant and negative (beta
## = -11.90, 95% CI [-26.20, 2.40], t(2038) = -1.63, p = 0.103; Std. beta = -0.84,
## 95% CI [-1.80, 0.13])
## - The effect of site [14R] is statistically non-significant and negative (beta
## = -9.17, 95% CI [-38.56, 20.21], t(2038) = -0.61, p = 0.540; Std. beta = -1.61,
## 95% CI [-5.05, 1.83])
## - The effect of site [15R] is statistically non-significant and negative (beta
## = -19.62, 95% CI [-46.20, 6.95], t(2038) = -1.45, p = 0.148; Std. beta = -1.59,
## 95% CI [-4.23, 1.05])
## - The effect of site [16R] is statistically non-significant and negative (beta
## = -8.12, 95% CI [-19.74, 3.51], t(2038) = -1.37, p = 0.171; Std. beta = -0.68,
## 95% CI [-1.50, 0.14])
## - The effect of site [17R] is statistically significant and positive (beta =
## 64.73, 95% CI [37.94, 91.52], t(2038) = 4.74, p < .001; Std. beta = 4.40, 95%
## CI [2.58, 6.22])
## - The effect of site [18R] is statistically non-significant and negative (beta
## = -1.56, 95% CI [-20.72, 17.61], t(2038) = -0.16, p = 0.874; Std. beta = -1.28,
## 95% CI [-3.83, 1.27])
## - The effect of site [19R] is statistically non-significant and negative (beta
## = -3.58, 95% CI [-16.92, 9.76], t(2038) = -0.53, p = 0.598; Std. beta = -0.15,
## 95% CI [-1.30, 1.01])
## - The effect of site [20R] is statistically non-significant and negative (beta
## = -2.32, 95% CI [-13.23, 8.60], t(2038) = -0.42, p = 0.678; Std. beta = -0.11,
## 95% CI [-0.93, 0.71])
## - The effect of site [21R] is statistically non-significant and negative (beta
## = -11.32, 95% CI [-36.06, 13.41], t(2038) = -0.90, p = 0.370; Std. beta =
## -0.20, 95% CI [-1.79, 1.38])
## - The effect of site [22R] is statistically significant and negative (beta =
## -14.16, 95% CI [-22.71, -5.61], t(2038) = -3.25, p = 0.001; Std. beta = -0.37,
## 95% CI [-1.02, 0.29])
## - The effect of site [23R] is statistically significant and negative (beta =
## -22.50, 95% CI [-38.54, -6.47], t(2038) = -2.75, p = 0.006; Std. beta = 0.72,
## 95% CI [-4.28, 5.73])
## - The effect of site [24R] is statistically non-significant and positive (beta
## = 1.76, 95% CI [-8.04, 11.55], t(2038) = 0.35, p = 0.725; Std. beta = -0.21,
## 95% CI [-0.88, 0.47])
## - The effect of site [25R] is statistically non-significant and negative (beta
## = -8.55, 95% CI [-19.48, 2.39], t(2038) = -1.53, p = 0.125; Std. beta = -0.70,
## 95% CI [-1.46, 0.07])
## - The effect of site [28R] is statistically non-significant and negative (beta
## = -15.37, 95% CI [-30.84, 0.10], t(2038) = -1.95, p = 0.051; Std. beta = -1.93,
## 95% CI [-4.53, 0.67])
## - The effect of site [29R] is statistically non-significant and negative (beta
## = -3.59, 95% CI [-29.58, 22.39], t(2038) = -0.27, p = 0.786; Std. beta = -0.36,
## 95% CI [-1.97, 1.26])
## - The effect of site [31R] is statistically non-significant and negative (beta
## = -0.80, 95% CI [-12.22, 10.61], t(2038) = -0.14, p = 0.890; Std. beta = 0.17,
## 95% CI [-0.56, 0.90])
## - The effect of site [32R] is statistically non-significant and positive (beta
## = 10.69, 95% CI [-6.48, 27.86], t(2038) = 1.22, p = 0.222; Std. beta = 0.40,
## 95% CI [-0.88, 1.67])
## - The effect of site [33R] is statistically non-significant and negative (beta
## = -5.90, 95% CI [-20.30, 8.49], t(2038) = -0.80, p = 0.421; Std. beta = -0.91,
## 95% CI [-1.99, 0.17])
## - The effect of site [34R] is statistically non-significant and negative (beta
## = -5.02, 95% CI [-14.80, 4.77], t(2038) = -1.01, p = 0.315; Std. beta = -0.24,
## 95% CI [-0.91, 0.44])
## - The effect of site [35R] is statistically non-significant and negative (beta
## = -14.45, 95% CI [-29.81, 0.91], t(2038) = -1.84, p = 0.065; Std. beta = -0.02,
## 95% CI [-1.12, 1.08])
## - The effect of site [36R] is statistically non-significant and positive (beta
## = 3.64, 95% CI [-7.98, 15.26], t(2038) = 0.61, p = 0.539; Std. beta = 0.75, 95%
## CI [-0.08, 1.59])
## - The effect of site [37R] is statistically non-significant and positive (beta
## = 0.04, 95% CI [-12.78, 12.86], t(2038) = 5.94e-03, p = 0.995; Std. beta =
## -0.11, 95% CI [-0.97, 0.75])
## - The effect of site [38R] is statistically non-significant and negative (beta
## = -1.06, 95% CI [-9.70, 7.57], t(2038) = -0.24, p = 0.809; Std. beta = -0.28,
## 95% CI [-0.85, 0.30])
## - The effect of site [39R] is statistically non-significant and positive (beta
## = 15.12, 95% CI [-11.08, 41.32], t(2038) = 1.13, p = 0.258; Std. beta = -2.14,
## 95% CI [-4.32, 0.05])
## - The effect of site [40R] is statistically non-significant and positive (beta
## = 1.49, 95% CI [-16.78, 19.76], t(2038) = 0.16, p = 0.873; Std. beta = 0.23,
## 95% CI [-1.10, 1.56])
## - The effect of site [41R] is statistically non-significant and negative (beta
## = -13.97, 95% CI [-29.08, 1.13], t(2038) = -1.81, p = 0.070; Std. beta = -0.50,
## 95% CI [-1.87, 0.87])
## - The effect of site [42R] is statistically significant and negative (beta =
## -10.83, 95% CI [-19.43, -2.23], t(2038) = -2.47, p = 0.014; Std. beta = -1.06,
## 95% CI [-2.16, 0.04])
## - The effect of time firstPFT × Soil 5yrPreCensor is statistically
## non-significant and positive (beta = 1.58, 95% CI [-2.55, 5.72], t(2038) =
## 0.75, p = 0.453; Std. beta = 0.05, 95% CI [-0.08, 0.17])
## - The effect of time firstPFT × disadv is statistically non-significant and
## positive (beta = 1.42, 95% CI [-0.76, 3.59], t(2038) = 1.28, p = 0.201; Std.
## beta = 0.05, 95% CI [-0.03, 0.13])
## - The effect of time firstPFT × dich Race [Non-White] is statistically
## non-significant and negative (beta = -0.59, 95% CI [-2.77, 1.58], t(2038) =
## -0.53, p = 0.593; Std. beta = -0.07, 95% CI [-0.34, 0.20])
## - The effect of time firstPFT × sex [F] is statistically non-significant and
## positive (beta = 0.71, 95% CI [-0.57, 2.00], t(2038) = 1.09, p = 0.275; Std.
## beta = 0.09, 95% CI [-0.07, 0.25])
## - The effect of time firstPFT × age dx is statistically non-significant and
## negative (beta = -0.04, 95% CI [-0.11, 0.03], t(2038) = -1.16, p = 0.245; Std.
## beta = -0.05, 95% CI [-0.12, 0.03])
## - The effect of time firstPFT × smokeHx [Former] is statistically
## non-significant and negative (beta = -0.61, 95% CI [-1.93, 0.71], t(2038) =
## -0.91, p = 0.363; Std. beta = -0.08, 95% CI [-0.24, 0.09])
## - The effect of time firstPFT × smokeHx [Always] is statistically
## non-significant and negative (beta = -6.31, 95% CI [-18.15, 5.54], t(2038) =
## -1.04, p = 0.297; Std. beta = -0.78, 95% CI [-2.25, 0.69])
## - The effect of time firstPFT × smokeHx [Unknown] is statistically
## non-significant and positive (beta = 2.20, 95% CI [-1.07, 5.46], t(2038) =
## 1.32, p = 0.187; Std. beta = 0.27, 95% CI [-0.13, 0.68])
## - The effect of time firstPFT × site [02R] is statistically non-significant and
## negative (beta = -33.03, 95% CI [-69.44, 3.38], t(2038) = -1.78, p = 0.075;
## Std. beta = -4.10, 95% CI [-8.62, 0.42])
## - The effect of time firstPFT × site [03R] is statistically non-significant and
## negative (beta = -1.66, 95% CI [-13.67, 10.35], t(2038) = -0.27, p = 0.786;
## Std. beta = -0.21, 95% CI [-1.70, 1.28])
## - The effect of time firstPFT × site [04R] is statistically non-significant and
## negative (beta = -2.59, 95% CI [-14.92, 9.74], t(2038) = -0.41, p = 0.681; Std.
## beta = -0.32, 95% CI [-1.85, 1.21])
## - The effect of time firstPFT × site [05R] is statistically non-significant and
## negative (beta = -3.34, 95% CI [-18.19, 11.51], t(2038) = -0.44, p = 0.659;
## Std. beta = -0.41, 95% CI [-2.26, 1.43])
## - The effect of time firstPFT × site [07R] is statistically non-significant and
## negative (beta = -2.19, 95% CI [-5.02, 0.65], t(2038) = -1.51, p = 0.131; Std.
## beta = -0.27, 95% CI [-0.62, 0.08])
## - The effect of time firstPFT × site [09R] is statistically non-significant and
## positive (beta = 2.09, 95% CI [-6.21, 10.39], t(2038) = 0.49, p = 0.621; Std.
## beta = 0.26, 95% CI [-0.77, 1.29])
## - The effect of time firstPFT × site [101] is statistically non-significant and
## negative (beta = -0.73, 95% CI [-2.87, 1.41], t(2038) = -0.67, p = 0.504; Std.
## beta = -0.09, 95% CI [-0.36, 0.18])
## - The effect of time firstPFT × site [102] is statistically non-significant and
## negative (beta = -0.83, 95% CI [-5.16, 3.49], t(2038) = -0.38, p = 0.706; Std.
## beta = -0.10, 95% CI [-0.64, 0.43])
## - The effect of time firstPFT × site [103] is statistically non-significant and
## positive (beta = 1.87, 95% CI [-0.34, 4.08], t(2038) = 1.66, p = 0.098; Std.
## beta = 0.23, 95% CI [-0.04, 0.51])
## - The effect of time firstPFT × site [104] is statistically non-significant and
## positive (beta = 2.19, 95% CI [-5.28, 9.66], t(2038) = 0.58, p = 0.565; Std.
## beta = 0.27, 95% CI [-0.65, 1.20])
## - The effect of time firstPFT × site [105] is statistically non-significant and
## positive (beta = 0.07, 95% CI [-2.14, 2.27], t(2038) = 0.06, p = 0.954; Std.
## beta = 8.11e-03, 95% CI [-0.27, 0.28])
## - The effect of time firstPFT × site [106] is statistically non-significant and
## positive (beta = 1.82, 95% CI [-1.40, 5.05], t(2038) = 1.11, p = 0.267; Std.
## beta = 0.23, 95% CI [-0.17, 0.63])
## - The effect of time firstPFT × site [107] is statistically non-significant and
## negative (beta = -12.31, 95% CI [-28.36, 3.74], t(2038) = -1.50, p = 0.133;
## Std. beta = -1.53, 95% CI [-3.52, 0.46])
## - The effect of time firstPFT × site [108] is statistically non-significant and
## positive (beta = 4.60, 95% CI [-2.43, 11.62], t(2038) = 1.28, p = 0.200; Std.
## beta = 0.57, 95% CI [-0.30, 1.44])
## - The effect of time firstPFT × site [11R] is statistically non-significant and
## positive (beta = 5.10, 95% CI [-0.57, 10.78], t(2038) = 1.76, p = 0.078; Std.
## beta = 0.63, 95% CI [-0.07, 1.34])
## - The effect of time firstPFT × site [12R] is statistically non-significant and
## positive (beta = 1.83, 95% CI [-6.06, 9.72], t(2038) = 0.45, p = 0.649; Std.
## beta = 0.23, 95% CI [-0.75, 1.21])
## - The effect of time firstPFT × site [13R] is statistically non-significant and
## negative (beta = -0.27, 95% CI [-8.08, 7.55], t(2038) = -0.07, p = 0.947; Std.
## beta = -0.03, 95% CI [-1.00, 0.94])
## - The effect of time firstPFT × site [14R] is statistically non-significant and
## negative (beta = -9.58, 95% CI [-56.11, 36.95], t(2038) = -0.40, p = 0.686;
## Std. beta = -1.19, 95% CI [-6.96, 4.58])
## - The effect of time firstPFT × site [15R] is statistically non-significant and
## negative (beta = -2.50, 95% CI [-30.30, 25.30], t(2038) = -0.18, p = 0.860;
## Std. beta = -0.31, 95% CI [-3.76, 3.14])
## - The effect of time firstPFT × site [16R] is statistically non-significant and
## negative (beta = -1.24, 95% CI [-6.49, 4.02], t(2038) = -0.46, p = 0.644; Std.
## beta = -0.15, 95% CI [-0.81, 0.50])
## - The effect of time firstPFT × site [18R] is statistically non-significant and
## negative (beta = -11.41, 95% CI [-36.99, 14.18], t(2038) = -0.87, p = 0.382;
## Std. beta = -1.42, 95% CI [-4.59, 1.76])
## - The effect of time firstPFT × site [19R] is statistically non-significant and
## positive (beta = 0.93, 95% CI [-9.36, 11.22], t(2038) = 0.18, p = 0.859; Std.
## beta = 0.12, 95% CI [-1.16, 1.39])
## - The effect of time firstPFT × site [20R] is statistically non-significant and
## positive (beta = 0.44, 95% CI [-6.30, 7.19], t(2038) = 0.13, p = 0.897; Std.
## beta = 0.06, 95% CI [-0.78, 0.89])
## - The effect of time firstPFT × site [21R] is statistically non-significant and
## positive (beta = 5.50, 95% CI [-3.88, 14.89], t(2038) = 1.15, p = 0.250; Std.
## beta = 0.68, 95% CI [-0.48, 1.85])
## - The effect of time firstPFT × site [22R] is statistically significant and
## positive (beta = 5.79, 95% CI [0.22, 11.35], t(2038) = 2.04, p = 0.042; Std.
## beta = 0.72, 95% CI [0.03, 1.41])
## - The effect of time firstPFT × site [23R] is statistically non-significant and
## positive (beta = 21.83, 95% CI [-30.80, 74.47], t(2038) = 0.81, p = 0.416; Std.
## beta = 2.71, 95% CI [-3.82, 9.24])
## - The effect of time firstPFT × site [24R] is statistically non-significant and
## negative (beta = -3.16, 95% CI [-8.03, 1.72], t(2038) = -1.27, p = 0.204; Std.
## beta = -0.39, 95% CI [-1.00, 0.21])
## - The effect of time firstPFT × site [25R] is statistically non-significant and
## negative (beta = -1.11, 95% CI [-7.04, 4.82], t(2038) = -0.37, p = 0.713; Std.
## beta = -0.14, 95% CI [-0.87, 0.60])
## - The effect of time firstPFT × site [28R] is statistically non-significant and
## negative (beta = -8.58, 95% CI [-34.39, 17.23], t(2038) = -0.65, p = 0.514;
## Std. beta = -1.06, 95% CI [-4.27, 2.14])
## - The effect of time firstPFT × site [29R] is statistically non-significant and
## negative (beta = -1.10, 95% CI [-11.16, 8.97], t(2038) = -0.21, p = 0.830; Std.
## beta = -0.14, 95% CI [-1.38, 1.11])
## - The effect of time firstPFT × site [31R] is statistically non-significant and
## positive (beta = 2.14, 95% CI [-1.83, 6.12], t(2038) = 1.06, p = 0.291; Std.
## beta = 0.27, 95% CI [-0.23, 0.76])
## - The effect of time firstPFT × site [32R] is statistically non-significant and
## negative (beta = -3.17, 95% CI [-12.62, 6.28], t(2038) = -0.66, p = 0.511; Std.
## beta = -0.39, 95% CI [-1.57, 0.78])
## - The effect of time firstPFT × site [33R] is statistically non-significant and
## negative (beta = -4.93, 95% CI [-12.80, 2.93], t(2038) = -1.23, p = 0.219; Std.
## beta = -0.61, 95% CI [-1.59, 0.36])
## - The effect of time firstPFT × site [34R] is statistically non-significant and
## positive (beta = 1.01, 95% CI [-3.72, 5.74], t(2038) = 0.42, p = 0.676; Std.
## beta = 0.13, 95% CI [-0.46, 0.71])
## - The effect of time firstPFT × site [35R] is statistically significant and
## positive (beta = 9.32, 95% CI [0.20, 18.45], t(2038) = 2.00, p = 0.045; Std.
## beta = 1.16, 95% CI [0.02, 2.29])
## - The effect of time firstPFT × site [36R] is statistically non-significant and
## positive (beta = 4.91, 95% CI [-0.92, 10.74], t(2038) = 1.65, p = 0.099; Std.
## beta = 0.61, 95% CI [-0.11, 1.33])
## - The effect of time firstPFT × site [37R] is statistically non-significant and
## negative (beta = -1.06, 95% CI [-6.85, 4.73], t(2038) = -0.36, p = 0.719; Std.
## beta = -0.13, 95% CI [-0.85, 0.59])
## - The effect of time firstPFT × site [38R] is statistically non-significant and
## negative (beta = -1.99, 95% CI [-5.73, 1.74], t(2038) = -1.05, p = 0.296; Std.
## beta = -0.25, 95% CI [-0.71, 0.22])
## - The effect of time firstPFT × site [39R] is statistically significant and
## negative (beta = -30.66, 95% CI [-51.25, -10.07], t(2038) = -2.92, p = 0.004;
## Std. beta = -3.80, 95% CI [-6.36, -1.25])
## - The effect of time firstPFT × site [40R] is statistically non-significant and
## positive (beta = 1.22, 95% CI [-7.86, 10.29], t(2038) = 0.26, p = 0.792; Std.
## beta = 0.15, 95% CI [-0.97, 1.28])
## - The effect of time firstPFT × site [41R] is statistically non-significant and
## positive (beta = 4.39, 95% CI [-8.71, 17.50], t(2038) = 0.66, p = 0.511; Std.
## beta = 0.55, 95% CI [-1.08, 2.17])
## - The effect of time firstPFT × site [42R] is statistically non-significant and
## negative (beta = -3.10, 95% CI [-14.79, 8.59], t(2038) = -0.52, p = 0.603; Std.
## beta = -0.38, 95% CI [-1.83, 1.07])
##
## Standardized parameters were obtained by fitting the model on a standardized
## version of the dataset. 95% Confidence Intervals (CIs) and p-values were
## computed using a Wald t-distribution approximation.